                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  OPTOGENETIC INDUCTION OF NEURODEGENERATIVE DISEASE PATHOLOGIES

<130>  10504-011WO1

<160>  102   

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2
<211>  498
<212>  PRT
<213>  Arabidopsis

<400>  2

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala 
        


<210>  3
<211>  119
<212>  PRT
<213>  Neurospora

<400>  3

Met Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
1               5                   10                  15      


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
            20                  25                  30          


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
        35                  40                  45              


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
    50                  55                  60                  


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
65                  70                  75                  80  


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
                85                  90                  95      


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
            100                 105                 110         


Gly Phe Gln Cys Glu Thr Glu 
        115                 


<210>  4
<211>  150
<212>  PRT
<213>  Neurospora

<400>  4

His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Tyr Leu Ile 
1               5                   10                  15      


Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp 
            20                  25                  30          


Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro 
        35                  40                  45              


Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn 
    50                  55                  60                  


Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly 
65                  70                  75                  80  


Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile 
                85                  90                  95      


Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu 
            100                 105                 110         


Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr 
        115                 120                 125             


Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly 
    130                 135                 140                 


Phe Gln Cys Glu Thr Glu 
145                 150 


<210>  5
<211>  150
<212>  PRT
<213>  Neurospora

<400>  5

His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile 
1               5                   10                  15      


Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp 
            20                  25                  30          


Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro 
        35                  40                  45              


Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn 
    50                  55                  60                  


Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly 
65                  70                  75                  80  


Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile 
                85                  90                  95      


Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu 
            100                 105                 110         


Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr 
        115                 120                 125             


Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly 
    130                 135                 140                 


Phe Gln Cys Glu Thr Glu 
145                 150 


<210>  6
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu 
            500                 505                 510         


Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu 
        515                 520                 525             


Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr 
    530                 535                 540                 


Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly 
545                 550                 555                 560 


Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val 
                565                 570                 575     


Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser 
            580                 585                 590         


Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile 
        595                 600                 605             


Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr 
    610                 615                 620                 


Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu 
625                 630                 635                 640 


Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr 
                645                 650                 655     


Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg 
            660                 665                 670         


Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro 
        675                 680                 685             


Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr 
    690                 695                 700                 


Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp 
705                 710                 715                 720 


Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala 
                725                 730                 735     


Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys 
            740                 745                 750         


Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn 
        755                 760                 765             


Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe 
    770                 775                 780                 


Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu 
785                 790                 795                 800 


Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala 
                805                 810                 815     


Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln 
            820                 825                 830         


Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser 
        835                 840                 845             


Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro 
    850                 855                 860                 


Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser 
                885                 890                 895     


Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly 
            900                 905                 910         


Trp Gly Met 
        915 


<210>  7
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Leu Glu 
                405                 410                 415     


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
            420                 425                 430         


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
        435                 440                 445             


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
    450                 455                 460                 


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
465                 470                 475                 480 


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
                485                 490                 495     


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
            500                 505                 510         


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
        515                 520                 525             


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
    530                 535                 540                 


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
545                 550                 555                 560 


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
                565                 570                 575     


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
            580                 585                 590         


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
        595                 600                 605             


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
    610                 615                 620                 


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
625                 630                 635                 640 


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
                645                 650                 655     


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
            660                 665                 670         


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
        675                 680                 685             


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
    690                 695                 700                 


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
705                 710                 715                 720 


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
                725                 730                 735     


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
            740                 745                 750         


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
        755                 760                 765             


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
    770                 775                 780                 


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
785                 790                 795                 800 


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
                805                 810                 815     


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
            820                 825                 830         


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
        835                 840                 845             


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
    850                 855                 860                 


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
865                 870                 875                 880 


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
                885                 890                 895     


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
            900                 905                 910         


Ile Gly Ala Ala 
        915     


<210>  8
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
1               5                   10                  15      


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            20                  25                  30          


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        35                  40                  45              


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    50                  55                  60                  


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                85                  90                  95      


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            100                 105                 110         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        115                 120                 125             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Leu Glu 
    130                 135                 140                 


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
                165                 170                 175     


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
            180                 185                 190         


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
        195                 200                 205             


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
    210                 215                 220                 


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
225                 230                 235                 240 


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
                245                 250                 255     


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
            260                 265                 270         


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
        275                 280                 285             


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
    290                 295                 300                 


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
305                 310                 315                 320 


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
                325                 330                 335     


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
            340                 345                 350         


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
        355                 360                 365             


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
    370                 375                 380                 


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
385                 390                 395                 400 


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
                405                 410                 415     


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
            420                 425                 430         


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
        435                 440                 445             


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
    450                 455                 460                 


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
465                 470                 475                 480 


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
                485                 490                 495     


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
            500                 505                 510         


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
        515                 520                 525             


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
    530                 535                 540                 


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
545                 550                 555                 560 


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
                565                 570                 575     


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
            580                 585                 590         


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
        595                 600                 605             


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
    610                 615                 620                 


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
625                 630                 635                 640 


Ile Gly Ala Ala 
                


<210>  9
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Met Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp 
1               5                   10                  15      


Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe 
            20                  25                  30          


Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp 
        35                  40                  45              


Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile 
    50                  55                  60                  


Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
                85                  90                  95      


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
            100                 105                 110         


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
        115                 120                 125             


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
    130                 135                 140                 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
145                 150                 155                 160 


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
                165                 170                 175     


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
            180                 185                 190         


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
        195                 200                 205             


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
    210                 215                 220                 


Met Leu Glu Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe 
225                 230                 235                 240 


Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala 
                245                 250                 255     


His Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu 
            260                 265                 270         


Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser 
        275                 280                 285             


Leu Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr 
    290                 295                 300                 


Leu Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg 
305                 310                 315                 320 


Val Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val 
                325                 330                 335     


Ser Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly 
            340                 345                 350         


Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu 
        355                 360                 365             


Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp 
    370                 375                 380                 


Lys Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro 
385                 390                 395                 400 


Trp Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys 
                405                 410                 415     


Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn 
            420                 425                 430         


Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys 
        435                 440                 445             


Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn 
    450                 455                 460                 


Ser Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu 
465                 470                 475                 480 


His Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met 
                485                 490                 495     


Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser 
            500                 505                 510         


Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr 
        515                 520                 525             


Ile Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His 
    530                 535                 540                 


Leu Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp 
545                 550                 555                 560 


Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu 
                565                 570                 575     


Leu Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser 
            580                 585                 590         


Ser Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys 
        595                 600                 605             


Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu 
    610                 615                 620                 


Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp 
625                 630                 635                 640 


Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly 
                645                 650                 655     


Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu 
            660                 665                 670         


Trp Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser 
        675                 680                 685             


Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp 
    690                 695                 700                 


Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala 
705                 710                 715                 720 


Gln Ile Met Ile Gly Ala Ala 
                725         


<210>  10
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Met Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
1               5                   10                  15      


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
            20                  25                  30          


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
        35                  40                  45              


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
    50                  55                  60                  


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
65                  70                  75                  80  


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
                85                  90                  95      


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
            100                 105                 110         


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
        115                 120                 125             


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
    130                 135                 140                 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
145                 150                 155                 160 


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
                165                 170                 175     


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
            180                 185                 190         


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
        195                 200                 205             


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
    210                 215                 220                 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
225                 230                 235                 240 


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
                245                 250                 255     


Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser 
            260                 265                 270         


Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala 
        275                 280                 285             


Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser 
    290                 295                 300                 


Lys Ser Ser Gly Trp Gly Met Leu Glu Ala Thr Met Lys Met Asp Lys 
305                 310                 315                 320 


Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro 
                325                 330                 335     


Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile 
            340                 345                 350         


Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg 
        355                 360                 365             


Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala 
    370                 375                 380                 


Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala 
385                 390                 395                 400 


Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn 
                405                 410                 415     


His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu 
            420                 425                 430         


Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu 
        435                 440                 445             


Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr 
    450                 455                 460                 


Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser 
465                 470                 475                 480 


Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala 
                485                 490                 495     


Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu 
            500                 505                 510         


Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly 
        515                 520                 525             


Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu 
    530                 535                 540                 


Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser 
545                 550                 555                 560 


Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val 
                565                 570                 575     


Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn 
            580                 585                 590         


Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu 
        595                 600                 605             


Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu 
    610                 615                 620                 


Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val 
625                 630                 635                 640 


Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val 
                645                 650                 655     


Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg 
            660                 665                 670         


Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro 
        675                 680                 685             


Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp 
    690                 695                 700                 


Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro 
705                 710                 715                 720 


Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala 
                725                 730                 735     


Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu 
            740                 745                 750         


Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu 
        755                 760                 765             


Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys 
    770                 775                 780                 


Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile 
785                 790                 795                 800 


Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala 
                805                 810             


<210>  11
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
            500                 505                 510         


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
        515                 520                 525             


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
    530                 535                 540                 


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
545                 550                 555                 560 


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
                565                 570                 575     


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
            580                 585                 590         


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
        595                 600                 605             


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
    610                 615                 620                 


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp 
625                 630                 635                 640 


Gly Met 
        


<210>  12
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp 
            500                 505                 510         


Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val 
        515                 520                 525             


Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr 
    530                 535                 540                 


Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile 
545                 550                 555                 560 


Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn 
                565                 570                 575     


Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly 
            580                 585                 590         


Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala 
        595                 600                 605             


Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe 
    610                 615                 620                 


Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala 
625                 630                 635                 640 


Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn 
                645                 650                 655     


Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg 
            660                 665                 670         


Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser 
        675                 680                 685             


Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser 
    690                 695                 700                 


Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser 
705                 710                 715                 720 


Ser Gly Trp Gly Met 
                725 


<210>  13
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr 
            500                 505                 510         


Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu 
        515                 520                 525             


Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe 
    530                 535                 540                 


Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser 
545                 550                 555                 560 


Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn 
                565                 570                 575     


Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val 
            580                 585                 590         


Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe 
        595                 600                 605             


Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg 
    610                 615                 620                 


Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu 
625                 630                 635                 640 


Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn 
                645                 650                 655     


Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg 
            660                 665                 670         


Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn 
        675                 680                 685             


Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met 
    690                 695                 700                 


Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met 
705                 710                 715                 720 


Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met 
                725                 730                 735     


Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn 
            740                 745                 750         


Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn 
        755                 760                 765             


Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser 
    770                 775                 780                 


Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser 
785                 790                 795                 800 


Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                805                 810     


<210>  14
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu 
            500                 505                 510         


Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu 
        515                 520                 525             


Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr 
    530                 535                 540                 


Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly 
545                 550                 555                 560 


Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val 
                565                 570                 575     


Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser 
            580                 585                 590         


Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile 
        595                 600                 605             


Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr 
    610                 615                 620                 


Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu 
625                 630                 635                 640 


Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr 
                645                 650                 655     


Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg 
            660                 665                 670         


Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro 
        675                 680                 685             


Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr 
    690                 695                 700                 


Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp 
705                 710                 715                 720 


Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala 
                725                 730                 735     


Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys 
            740                 745                 750         


Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn 
        755                 760                 765             


Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe 
    770                 775                 780                 


Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu 
785                 790                 795                 800 


Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala 
                805                 810                 815     


Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln 
            820                 825                 830         


Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser 
        835                 840                 845             


Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro 
    850                 855                 860                 


Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser 
                885                 890                 895     


Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly 
            900                 905                 910         


Trp Gly Met Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        915                 920                 925             


Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val 
    930                 935                 940                 


His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
945                 950                 955                 960 


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
                965                 970                 975     


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
            980                 985                 990         


Phe Met Tyr Gly Ser Lys Ala Tyr  Val Lys His Pro Ala  Asp Ile Pro 
        995                 1000                 1005             


Asp Tyr  Leu Lys Leu Ser Phe  Pro Glu Gly Phe Lys  Trp Glu Arg 
    1010                 1015                 1020             


Val Met  Asn Phe Glu Asp Gly  Gly Val Val Thr Val  Thr Gln Asp 
    1025                 1030                 1035             


Ser Ser  Leu Gln Asp Gly Glu  Phe Ile Tyr Lys Val  Lys Leu Arg 
    1040                 1045                 1050             


Gly Thr  Asn Phe Pro Ser Asp  Gly Pro Val Met Gln  Lys Lys Thr 
    1055                 1060                 1065             


Met Gly  Trp Glu Ala Ser Ser  Glu Arg Met Tyr Pro  Glu Asp Gly 
    1070                 1075                 1080             


Ala Leu  Lys Gly Glu Ile Lys  Gln Arg Leu Lys Leu  Lys Asp Gly 
    1085                 1090                 1095             


Gly His  Tyr Asp Ala Glu Val  Lys Thr Thr Tyr Lys  Ala Lys Lys 
    1100                 1105                 1110             


Pro Val  Gln Leu Pro Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp 
    1115                 1120                 1125             


Ile Thr  Ser His Asn Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu 
    1130                 1135                 1140             


Arg Ala  Glu Gly Arg His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr 
    1145                 1150                 1155             


Lys 
    


<210>  15
<211>  1160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Leu Glu 
                405                 410                 415     


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
            420                 425                 430         


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
        435                 440                 445             


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
    450                 455                 460                 


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
465                 470                 475                 480 


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
                485                 490                 495     


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
            500                 505                 510         


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
        515                 520                 525             


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
    530                 535                 540                 


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
545                 550                 555                 560 


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
                565                 570                 575     


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
            580                 585                 590         


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
        595                 600                 605             


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
    610                 615                 620                 


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
625                 630                 635                 640 


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
                645                 650                 655     


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
            660                 665                 670         


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
        675                 680                 685             


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
    690                 695                 700                 


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
705                 710                 715                 720 


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
                725                 730                 735     


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
            740                 745                 750         


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
        755                 760                 765             


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
    770                 775                 780                 


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
785                 790                 795                 800 


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
                805                 810                 815     


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
            820                 825                 830         


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
        835                 840                 845             


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
    850                 855                 860                 


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
865                 870                 875                 880 


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
                885                 890                 895     


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
            900                 905                 910         


Ile Gly Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys 
        915                 920                 925             


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
    930                 935                 940                 


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
945                 950                 955                 960 


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
                965                 970                 975     


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
            980                 985                 990         


Gln Phe Met Tyr Gly Ser Lys Ala  Tyr Val Lys His Pro  Ala Asp Ile 
        995                 1000                 1005             


Pro Asp  Tyr Leu Lys Leu Ser  Phe Pro Glu Gly Phe  Lys Trp Glu 
    1010                 1015                 1020             


Arg Val  Met Asn Phe Glu Asp  Gly Gly Val Val Thr  Val Thr Gln 
    1025                 1030                 1035             


Asp Ser  Ser Leu Gln Asp Gly  Glu Phe Ile Tyr Lys  Val Lys Leu 
    1040                 1045                 1050             


Arg Gly  Thr Asn Phe Pro Ser  Asp Gly Pro Val Met  Gln Lys Lys 
    1055                 1060                 1065             


Thr Met  Gly Trp Glu Ala Ser  Ser Glu Arg Met Tyr  Pro Glu Asp 
    1070                 1075                 1080             


Gly Ala  Leu Lys Gly Glu Ile  Lys Gln Arg Leu Lys  Leu Lys Asp 
    1085                 1090                 1095             


Gly Gly  His Tyr Asp Ala Glu  Val Lys Thr Thr Tyr  Lys Ala Lys 
    1100                 1105                 1110             


Lys Pro  Val Gln Leu Pro Gly  Ala Tyr Asn Val Asn  Ile Lys Leu 
    1115                 1120                 1125             


Asp Ile  Thr Ser His Asn Glu  Asp Tyr Thr Ile Val  Glu Gln Tyr 
    1130                 1135                 1140             


Glu Arg  Ala Glu Gly Arg His  Ser Thr Gly Gly Met  Asp Glu Leu 
    1145                 1150                 1155             


Tyr Lys  
    1160 


<210>  16
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Met Ser Glu Tyr 
225                 230                 235                 240 


Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile Glu Ile Pro Ser 
                245                 250                 255     


Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr Ala Gln Phe Pro 
            260                 265                 270         


Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser Gln Cys Met Arg 
        275                 280                 285             


Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro Asp Ala Gly Trp 
    290                 295                 300                 


Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp Asn Lys Arg Lys 
305                 310                 315                 320 


Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val Lys Arg Ala Val 
                325                 330                 335     


Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr 
            340                 345                 350         


Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met 
        355                 360                 365             


Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly 
    370                 375                 380                 


Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln 
385                 390                 395                 400 


Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser 
                405                 410                 415     


Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly 
            420                 425                 430         


Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser 
        435                 440                 445             


Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala 
    450                 455                 460                 


Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys 
465                 470                 475                 480 


Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala 
                485                 490                 495     


Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe 
            500                 505                 510         


Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser 
        515                 520                 525             


Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly 
    530                 535                 540                 


Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala 
545                 550                 555                 560 


Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu 
                565                 570                 575     


Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln 
            580                 585                 590         


Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn 
        595                 600                 605             


Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala 
    610                 615                 620                 


Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser 
625                 630                 635                 640 


Met Asp Ser Lys Ser Ser Gly Trp Gly Met Leu Glu Ala Thr Met Lys 
                645                 650                 655     


Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu 
            660                 665                 670         


Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro 
        675                 680                 685             


Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg 
    690                 695                 700                 


Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser 
705                 710                 715                 720 


Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr 
                725                 730                 735     


Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val 
            740                 745                 750         


Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr 
        755                 760                 765             


Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn 
    770                 775                 780                 


Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys 
785                 790                 795                 800 


Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser 
                805                 810                 815     


Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr 
            820                 825                 830         


Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu 
        835                 840                 845             


Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp 
    850                 855                 860                 


Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu 
865                 870                 875                 880 


Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn 
                885                 890                 895     


Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val 
            900                 905                 910         


Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg 
        915                 920                 925             


Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly 
    930                 935                 940                 


Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe 
945                 950                 955                 960 


Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp 
                965                 970                 975     


Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr 
            980                 985                 990         


Pro Leu Val Asp Ala Gly Met Arg  Glu Leu Trp Ala Thr  Gly Trp Met 
        995                 1000                 1005             


His Asn  Arg Ile Arg Val Ile  Val Ser Ser Phe Ala  Val Lys Phe 
    1010                 1015                 1020             


Leu Leu  Leu Pro Trp Lys Trp  Gly Met Lys Tyr Phe  Trp Asp Thr 
    1025                 1030                 1035             


Leu Leu  Asp Ala Asp Leu Glu  Cys Asp Ile Leu Gly  Trp Gln Tyr 
    1040                 1045                 1050             


Ile Ser  Gly Ser Ile Pro Asp  Gly His Glu Leu Asp  Arg Leu Asp 
    1055                 1060                 1065             


Asn Pro  Ala Leu Gln Gly Ala  Lys Tyr Asp Pro Glu  Gly Glu Tyr 
    1070                 1075                 1080             


Ile Arg  Gln Trp Leu Pro Glu  Leu Ala Arg Leu Pro  Thr Glu Trp 
    1085                 1090                 1095             


Ile His  His Pro Trp Asp Ala  Pro Leu Thr Val Leu  Lys Ala Ser 
    1100                 1105                 1110             


Gly Val  Glu Leu Gly Thr Asn  Tyr Ala Lys Pro Ile  Val Asp Ile 
    1115                 1120                 1125             


Asp Thr  Ala Arg Glu Leu Leu  Ala Lys Ala Ile Ser  Arg Thr Arg 
    1130                 1135                 1140             


Gly Ala  Gln Ile Met Ile Gly  Ala Ala 
    1145                 1150         


<210>  17
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Met Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
1               5                   10                  15      


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            20                  25                  30          


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        35                  40                  45              


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    50                  55                  60                  


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                85                  90                  95      


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            100                 105                 110         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        115                 120                 125             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Leu Glu 
    130                 135                 140                 


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
                165                 170                 175     


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
            180                 185                 190         


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
        195                 200                 205             


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
    210                 215                 220                 


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
225                 230                 235                 240 


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
                245                 250                 255     


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
            260                 265                 270         


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
        275                 280                 285             


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
    290                 295                 300                 


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
305                 310                 315                 320 


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
                325                 330                 335     


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
            340                 345                 350         


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
        355                 360                 365             


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
    370                 375                 380                 


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
385                 390                 395                 400 


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
                405                 410                 415     


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
            420                 425                 430         


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
        435                 440                 445             


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
    450                 455                 460                 


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
465                 470                 475                 480 


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
                485                 490                 495     


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
            500                 505                 510         


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
        515                 520                 525             


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
    530                 535                 540                 


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
545                 550                 555                 560 


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
                565                 570                 575     


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
            580                 585                 590         


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
        595                 600                 605             


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
    610                 615                 620                 


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
625                 630                 635                 640 


Ile Gly Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys 
                645                 650                 655     


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
            660                 665                 670         


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
        675                 680                 685             


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
    690                 695                 700                 


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
705                 710                 715                 720 


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
                725                 730                 735     


Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
            740                 745                 750         


Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser 
        755                 760                 765             


Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr 
    770                 775                 780                 


Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
785                 790                 795                 800 


Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly 
                805                 810                 815     


Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala 
            820                 825                 830         


Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly 
        835                 840                 845             


Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
    850                 855                 860                 


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr 
865                 870                 875                 880 


Gly Gly Met Asp Glu Leu Tyr Lys 
                885             


<210>  18
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Met Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp 
1               5                   10                  15      


Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe 
            20                  25                  30          


Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp 
        35                  40                  45              


Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile 
    50                  55                  60                  


Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
                85                  90                  95      


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
            100                 105                 110         


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
        115                 120                 125             


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
    130                 135                 140                 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
145                 150                 155                 160 


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
                165                 170                 175     


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
            180                 185                 190         


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
        195                 200                 205             


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
    210                 215                 220                 


Met Leu Glu Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe 
225                 230                 235                 240 


Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala 
                245                 250                 255     


His Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu 
            260                 265                 270         


Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser 
        275                 280                 285             


Leu Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr 
    290                 295                 300                 


Leu Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg 
305                 310                 315                 320 


Val Thr Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val 
                325                 330                 335     


Ser Leu Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly 
            340                 345                 350         


Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu 
        355                 360                 365             


Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp 
    370                 375                 380                 


Lys Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro 
385                 390                 395                 400 


Trp Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys 
                405                 410                 415     


Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn 
            420                 425                 430         


Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys 
        435                 440                 445             


Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn 
    450                 455                 460                 


Ser Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu 
465                 470                 475                 480 


His Phe Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met 
                485                 490                 495     


Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser 
            500                 505                 510         


Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr 
        515                 520                 525             


Ile Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His 
    530                 535                 540                 


Leu Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp 
545                 550                 555                 560 


Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu 
                565                 570                 575     


Leu Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser 
            580                 585                 590         


Ser Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys 
        595                 600                 605             


Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu 
    610                 615                 620                 


Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp 
625                 630                 635                 640 


Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly 
                645                 650                 655     


Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu 
            660                 665                 670         


Trp Ile His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser 
        675                 680                 685             


Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp 
    690                 695                 700                 


Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala 
705                 710                 715                 720 


Gln Ile Met Ile Gly Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met 
                725                 730                 735     


Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
            740                 745                 750         


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
        755                 760                 765             


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
    770                 775                 780                 


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
785                 790                 795                 800 


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
                805                 810                 815     


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
            820                 825                 830         


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
        835                 840                 845             


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
    850                 855                 860                 


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
865                 870                 875                 880 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
                885                 890                 895     


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
            900                 905                 910         


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
        915                 920                 925             


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
    930                 935                 940                 


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
945                 950                 955                 960 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                965                 970     


<210>  19
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19

Met Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
1               5                   10                  15      


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
            20                  25                  30          


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
        35                  40                  45              


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
    50                  55                  60                  


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
65                  70                  75                  80  


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
                85                  90                  95      


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
            100                 105                 110         


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
        115                 120                 125             


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
    130                 135                 140                 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
145                 150                 155                 160 


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
                165                 170                 175     


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
            180                 185                 190         


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
        195                 200                 205             


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
    210                 215                 220                 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
225                 230                 235                 240 


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
                245                 250                 255     


Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser 
            260                 265                 270         


Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala 
        275                 280                 285             


Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser 
    290                 295                 300                 


Lys Ser Ser Gly Trp Gly Met Leu Glu Ala Thr Met Lys Met Asp Lys 
305                 310                 315                 320 


Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro 
                325                 330                 335     


Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile 
            340                 345                 350         


Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg 
        355                 360                 365             


Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala 
    370                 375                 380                 


Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala 
385                 390                 395                 400 


Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn 
                405                 410                 415     


His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu 
            420                 425                 430         


Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu 
        435                 440                 445             


Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr 
    450                 455                 460                 


Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser 
465                 470                 475                 480 


Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala 
                485                 490                 495     


Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu 
            500                 505                 510         


Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly 
        515                 520                 525             


Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu 
    530                 535                 540                 


Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser 
545                 550                 555                 560 


Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val 
                565                 570                 575     


Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn 
            580                 585                 590         


Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu 
        595                 600                 605             


Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu 
    610                 615                 620                 


Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val 
625                 630                 635                 640 


Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val 
                645                 650                 655     


Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg 
            660                 665                 670         


Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro 
        675                 680                 685             


Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp 
    690                 695                 700                 


Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro 
705                 710                 715                 720 


Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala 
                725                 730                 735     


Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu 
            740                 745                 750         


Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu 
        755                 760                 765             


Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys 
    770                 775                 780                 


Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile 
785                 790                 795                 800 


Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ala Arg Asp 
                805                 810                 815     


Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala 
            820                 825                 830         


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
        835                 840                 845             


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
    850                 855                 860                 


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
865                 870                 875                 880 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
                885                 890                 895     


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
            900                 905                 910         


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
        915                 920                 925             


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
    930                 935                 940                 


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
945                 950                 955                 960 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
                965                 970                 975     


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
            980                 985                 990         


Leu Lys Asp Gly Gly His Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys 
        995                 1000                 1005             


Ala Lys  Lys Pro Val Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile 
    1010                 1015                 1020             


Lys Leu  Asp Ile Thr Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu 
    1025                 1030                 1035             


Gln Tyr  Glu Arg Ala Glu Gly  Arg His Ser Thr Gly  Gly Met Asp 
    1040                 1045                 1050             


Glu Leu  Tyr Lys 
    1055         


<210>  20
<211>  878
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Met Lys Met Asp 
225                 230                 235                 240 


Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn 
                245                 250                 255     


Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe 
            260                 265                 270         


Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser 
        275                 280                 285             


Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys 
    290                 295                 300                 


Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser 
305                 310                 315                 320 


Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe 
                325                 330                 335     


Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys 
            340                 345                 350         


Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp 
        355                 360                 365             


Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe 
    370                 375                 380                 


Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu 
385                 390                 395                 400 


Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala 
                405                 410                 415     


Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn 
            420                 425                 430         


Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro 
        435                 440                 445             


Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln 
    450                 455                 460                 


Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr 
465                 470                 475                 480 


Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His 
                485                 490                 495     


Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys 
            500                 505                 510         


Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly 
        515                 520                 525             


Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His 
    530                 535                 540                 


Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp 
545                 550                 555                 560 


Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu 
                565                 570                 575     


Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn 
            580                 585                 590         


Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu 
        595                 600                 605             


Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala 
    610                 615                 620                 


Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile 
625                 630                 635                 640 


Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly 
                645                 650                 655     


Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu 
            660                 665                 670         


Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro 
        675                 680                 685             


Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala 
    690                 695                 700                 


Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala 
705                 710                 715                 720 


Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ala Arg 
                725                 730                 735     


Gly Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
            740                 745                 750         


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
        755                 760                 765             


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
    770                 775                 780                 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
785                 790                 795                 800 


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
                805                 810                 815     


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
            820                 825                 830         


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
        835                 840                 845             


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
    850                 855                 860                 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
865                 870                 875             


<210>  21
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Met Lys Met Asp 
225                 230                 235                 240 


Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn 
                245                 250                 255     


Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe 
            260                 265                 270         


Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser 
        275                 280                 285             


Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys 
    290                 295                 300                 


Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser 
305                 310                 315                 320 


Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe 
                325                 330                 335     


Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys 
            340                 345                 350         


Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp 
        355                 360                 365             


Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe 
    370                 375                 380                 


Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu 
385                 390                 395                 400 


Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala 
                405                 410                 415     


Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn 
            420                 425                 430         


Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro 
        435                 440                 445             


Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln 
    450                 455                 460                 


Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr 
465                 470                 475                 480 


Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His 
                485                 490                 495     


Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys 
            500                 505                 510         


Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly 
        515                 520                 525             


Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His 
    530                 535                 540                 


Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp 
545                 550                 555                 560 


Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu 
                565                 570                 575     


Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn 
            580                 585                 590         


Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu 
        595                 600                 605             


Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala 
    610                 615                 620                 


Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile 
625                 630                 635                 640 


Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly 
                645                 650                 655     


Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu 
            660                 665                 670         


Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro 
        675                 680                 685             


Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala 
    690                 695                 700                 


Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala 
705                 710                 715                 720 


Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ala Arg 
                725                 730                 735     


Gly Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp 
            740                 745                 750         


Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe 
        755                 760                 765             


Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp 
    770                 775                 780                 


Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile 
785                 790                 795                 800 


Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln 
                805                 810                 815     


Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
            820                 825                 830         


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
        835                 840                 845             


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
    850                 855                 860                 


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
865                 870                 875                 880 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
                885                 890                 895     


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
            900                 905                 910         


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
        915                 920                 925             


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
    930                 935                 940                 


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
945                 950                 955                 960 


Met 
    


<210>  22
<211>  1047
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Met Lys Met Asp 
225                 230                 235                 240 


Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn 
                245                 250                 255     


Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe 
            260                 265                 270         


Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser 
        275                 280                 285             


Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys 
    290                 295                 300                 


Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser 
305                 310                 315                 320 


Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe 
                325                 330                 335     


Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys 
            340                 345                 350         


Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp 
        355                 360                 365             


Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe 
    370                 375                 380                 


Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu 
385                 390                 395                 400 


Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala 
                405                 410                 415     


Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn 
            420                 425                 430         


Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro 
        435                 440                 445             


Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln 
    450                 455                 460                 


Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr 
465                 470                 475                 480 


Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His 
                485                 490                 495     


Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys 
            500                 505                 510         


Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly 
        515                 520                 525             


Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His 
    530                 535                 540                 


Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp 
545                 550                 555                 560 


Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu 
                565                 570                 575     


Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn 
            580                 585                 590         


Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu 
        595                 600                 605             


Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala 
    610                 615                 620                 


Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile 
625                 630                 635                 640 


Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly 
                645                 650                 655     


Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu 
            660                 665                 670         


Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro 
        675                 680                 685             


Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala 
    690                 695                 700                 


Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala 
705                 710                 715                 720 


Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ala Arg 
                725                 730                 735     


Gly Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
            740                 745                 750         


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
        755                 760                 765             


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
    770                 775                 780                 


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
785                 790                 795                 800 


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
                805                 810                 815     


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
            820                 825                 830         


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
        835                 840                 845             


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
    850                 855                 860                 


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
865                 870                 875                 880 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
                885                 890                 895     


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
            900                 905                 910         


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
        915                 920                 925             


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
    930                 935                 940                 


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
945                 950                 955                 960 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
                965                 970                 975     


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
            980                 985                 990         


Gln Arg Glu Pro Asn Gln Ala Phe  Gly Ser Gly Asn Asn  Ser Tyr Ser 
        995                 1000                 1005             


Gly Ser  Asn Ser Gly Ala Ala  Ile Gly Trp Gly Ser  Ala Ser Asn 
    1010                 1015                 1020             


Ala Gly  Ser Gly Ser Gly Phe  Asn Gly Gly Phe Gly  Ser Ser Met 
    1025                 1030                 1035             


Asp Ser  Lys Ser Ser Gly Trp  Gly Met 
    1040                 1045         


<210>  23
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
            500                 505                 510         


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
        515                 520                 525             


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
    530                 535                 540                 


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
545                 550                 555                 560 


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
                565                 570                 575     


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
            580                 585                 590         


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
        595                 600                 605             


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
    610                 615                 620                 


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp 
625                 630                 635                 640 


Gly Met Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu 
                645                 650                 655     


Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
            660                 665                 670         


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
        675                 680                 685             


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
    690                 695                 700                 


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
705                 710                 715                 720 


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
                725                 730                 735     


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
            740                 745                 750         


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
        755                 760                 765             


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
    770                 775                 780                 


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
785                 790                 795                 800 


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
                805                 810                 815     


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
            820                 825                 830         


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
        835                 840                 845             


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
    850                 855                 860                 


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
865                 870                 875                 880 


Met Asp Glu Leu Tyr Lys 
                885     


<210>  24
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp 
            500                 505                 510         


Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val 
        515                 520                 525             


Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr 
    530                 535                 540                 


Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile 
545                 550                 555                 560 


Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn 
                565                 570                 575     


Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly 
            580                 585                 590         


Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala 
        595                 600                 605             


Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe 
    610                 615                 620                 


Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala 
625                 630                 635                 640 


Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn 
                645                 650                 655     


Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg 
            660                 665                 670         


Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser 
        675                 680                 685             


Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser 
    690                 695                 700                 


Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser 
705                 710                 715                 720 


Ser Gly Trp Gly Met Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser 
                725                 730                 735     


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
            740                 745                 750         


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
        755                 760                 765             


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
    770                 775                 780                 


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
785                 790                 795                 800 


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
                805                 810                 815     


Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
            820                 825                 830         


Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp 
        835                 840                 845             


Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly 
    850                 855                 860                 


Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
865                 870                 875                 880 


Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys 
                885                 890                 895     


Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp 
            900                 905                 910         


Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro 
        915                 920                 925             


Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu 
    930                 935                 940                 


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser 
945                 950                 955                 960 


Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                965                 


<210>  25
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Met Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
1               5                   10                  15      


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
            20                  25                  30          


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
        35                  40                  45              


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
    50                  55                  60                  


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
65                  70                  75                  80  


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
                85                  90                  95      


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
            100                 105                 110         


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
        115                 120                 125             


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
    130                 135                 140                 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
145                 150                 155                 160 


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
                165                 170                 175     


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
            180                 185                 190         


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
        195                 200                 205             


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
    210                 215                 220                 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
225                 230                 235                 240 


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
                245                 250                 255     


Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser 
            260                 265                 270         


Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala 
        275                 280                 285             


Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser 
    290                 295                 300                 


Lys Ser Ser Gly Trp Gly Met Leu Glu Ala Thr Met Lys Met Asp Lys 
305                 310                 315                 320 


Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro 
                325                 330                 335     


Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile 
            340                 345                 350         


Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg 
        355                 360                 365             


Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala 
    370                 375                 380                 


Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala 
385                 390                 395                 400 


Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn 
                405                 410                 415     


His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu 
            420                 425                 430         


Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu 
        435                 440                 445             


Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr 
    450                 455                 460                 


Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser 
465                 470                 475                 480 


Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala 
                485                 490                 495     


Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu 
            500                 505                 510         


Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly 
        515                 520                 525             


Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu 
    530                 535                 540                 


Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser 
545                 550                 555                 560 


Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val 
                565                 570                 575     


Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn 
            580                 585                 590         


Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu 
        595                 600                 605             


Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu 
    610                 615                 620                 


Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val 
625                 630                 635                 640 


Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val 
                645                 650                 655     


Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg 
            660                 665                 670         


Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro 
        675                 680                 685             


Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp 
    690                 695                 700                 


Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro 
705                 710                 715                 720 


Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala 
                725                 730                 735     


Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu 
            740                 745                 750         


Ala Arg Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu 
        755                 760                 765             


Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys 
    770                 775                 780                 


Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile 
785                 790                 795                 800 


Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ser Arg Asp 
                805                 810                 815     


Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala 
            820                 825                 830         


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
        835                 840                 845             


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
    850                 855                 860                 


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
865                 870                 875                 880 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
                885                 890                 895     


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
            900                 905                 910         


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
        915                 920                 925             


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
    930                 935                 940                 


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
945                 950                 955                 960 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
                965                 970                 975     


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
            980                 985                 990         


Leu Lys Asp Gly Gly His Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys 
        995                 1000                 1005             


Ala Lys  Lys Pro Val Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile 
    1010                 1015                 1020             


Lys Leu  Asp Ile Thr Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu 
    1025                 1030                 1035             


Gln Tyr  Glu Arg Ala Glu Gly  Arg His Ser Thr Gly  Gly Met Asp 
    1040                 1045                 1050             


Glu Leu  Tyr Lys 
    1055         


<210>  26
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Met Ser Glu Tyr Ile Arg Val Thr 
145                 150                 155                 160 


Glu Asp Glu Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly 
                165                 170                 175     


Thr Val Leu Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly 
            180                 185                 190         


Leu Arg Tyr Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu 
        195                 200                 205             


Val Glu Gly Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val 
    210                 215                 220                 


Tyr Val Val Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr 
225                 230                 235                 240 


Asp Ala Ser Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser 
                245                 250                 255     


Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu 
            260                 265                 270         


Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys 
        275                 280                 285             


Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe 
    290                 295                 300                 


Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile 
305                 310                 315                 320 


Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln 
                325                 330                 335     


Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu 
            340                 345                 350         


Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp 
        355                 360                 365             


Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val 
    370                 375                 380                 


Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu 
385                 390                 395                 400 


Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His 
                405                 410                 415     


Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro 
            420                 425                 430         


Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly 
        435                 440                 445             


Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn 
    450                 455                 460                 


Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala 
465                 470                 475                 480 


Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln 
                485                 490                 495     


Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln 
            500                 505                 510         


Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly 
        515                 520                 525             


Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly 
    530                 535                 540                 


Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys 
545                 550                 555                 560 


Ser Ser Gly Trp Gly Met 
                565     


<210>  27
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Phe Arg 
                405                 410                 415     


Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly 
            420                 425                 430         


Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly 
        435                 440                 445             


Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys 
    450                 455                 460                 


Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly 
465                 470                 475                 480 


Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser 
                485                 490                 495     


Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser 
            500                 505                 510         


Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val 
        515                 520                 525             


Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn 
    530                 535                 540                 


Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr 
545                 550                 555                 560 


Ser Met Gly Phe Gln Cys Glu Thr Glu 
                565                 


<210>  28
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Met Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
1               5                   10                  15      


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
            20                  25                  30          


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
        35                  40                  45              


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
    50                  55                  60                  


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
65                  70                  75                  80  


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
                85                  90                  95      


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
            100                 105                 110         


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
        115                 120                 125             


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
    130                 135                 140                 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
145                 150                 155                 160 


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
                165                 170                 175     


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
            180                 185                 190         


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
        195                 200                 205             


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
    210                 215                 220                 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
225                 230                 235                 240 


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
                245                 250                 255     


Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser 
            260                 265                 270         


Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala 
        275                 280                 285             


Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser 
    290                 295                 300                 


Lys Ser Ser Gly Trp Gly Met Phe Arg Ala Gln Arg His Thr Leu Tyr 
305                 310                 315                 320 


Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn 
                325                 330                 335     


Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala 
            340                 345                 350         


Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala 
        355                 360                 365             


Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu 
    370                 375                 380                 


Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro 
385                 390                 395                 400 


Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg 
                405                 410                 415     


Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe 
            420                 425                 430         


Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val 
        435                 440                 445             


Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu 
    450                 455                 460                 


Thr Glu 
465     


<210>  29
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Met Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp 
1               5                   10                  15      


Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe 
            20                  25                  30          


Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp 
        35                  40                  45              


Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile 
    50                  55                  60                  


Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
                85                  90                  95      


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
            100                 105                 110         


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
        115                 120                 125             


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
    130                 135                 140                 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
145                 150                 155                 160 


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
                165                 170                 175     


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
            180                 185                 190         


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
        195                 200                 205             


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
    210                 215                 220                 


Met Phe Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp 
225                 230                 235                 240 


Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val 
                245                 250                 255     


Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu 
            260                 265                 270         


Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr 
        275                 280                 285             


Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe 
    290                 295                 300                 


Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr 
305                 310                 315                 320 


Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn 
                325                 330                 335     


Ala Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg 
            340                 345                 350         


Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu 
        355                 360                 365             


Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
    370                 375                 380 


<210>  30
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Met Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
1               5                   10                  15      


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            20                  25                  30          


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        35                  40                  45              


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    50                  55                  60                  


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                85                  90                  95      


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            100                 105                 110         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        115                 120                 125             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Phe Arg 
    130                 135                 140                 


Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly 
145                 150                 155                 160 


Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly 
                165                 170                 175     


Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys 
            180                 185                 190         


Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly 
        195                 200                 205             


Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser 
    210                 215                 220                 


Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser 
225                 230                 235                 240 


Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val 
                245                 250                 255     


Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn 
            260                 265                 270         


Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr 
        275                 280                 285             


Ser Met Gly Phe Gln Cys Glu Thr Glu 
    290                 295         


<210>  31
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Asp Leu Ile Val Leu Gly Leu Pro 
145                 150                 155                 160 


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
                165                 170                 175     


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
            180                 185                 190         


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
        195                 200                 205             


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
    210                 215                 220                 


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
225                 230                 235                 240 


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
                245                 250                 255     


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
            260                 265                 270         


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
        275                 280                 285             


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
    290                 295                 300                 


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
305                 310                 315                 320 


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
                325                 330                 335     


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            340                 345                 350         


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        355                 360                 365             


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    370                 375                 380                 


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
385                 390                 395                 400 


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                405                 410                 415     


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            420                 425                 430         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        435                 440                 445             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
    450                 455                 460         


<210>  32
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Arg Lys Val Phe Val Gly Arg Cys 
145                 150                 155                 160 


Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr 
                165                 170                 175     


Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala 
            180                 185                 190         


Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu 
        195                 200                 205             


Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro 
    210                 215                 220                 


Lys His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly 
225                 230                 235                 240 


Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly 
                245                 250                 255     


Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly 
            260                 265                 270         


Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala 
        275                 280                 285             


Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser 
    290                 295                 300                 


Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn 
305                 310                 315                 320 


Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr 
                325                 330                 335     


Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn 
            340                 345                 350         


Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp 
        355                 360                 365             


Ser Lys Ser Ser Gly Trp Gly Met 
    370                 375     


<210>  33
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile 
1               5                   10                  15      


Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp 
            20                  25                  30          


Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro 
        35                  40                  45              


Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn 
    50                  55                  60                  


Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly 
65                  70                  75                  80  


Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile 
                85                  90                  95      


Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu 
            100                 105                 110         


Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr 
        115                 120                 125             


Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly 
    130                 135                 140                 


Phe Gln Cys Glu Thr Glu Ala Gly Arg Phe Gly Gly Asn Pro Gly Gly 
145                 150                 155                 160 


Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly 
                165                 170                 175     


Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly 
            180                 185                 190         


Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu 
        195                 200                 205             


Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln 
    210                 215                 220                 


Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu 
225                 230                 235                 240 


Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn 
                245                 250                 255     


Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly 
            260                 265                 270         


Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser 
        275                 280                 285             


Gly Trp Gly Met 
    290         


<210>  34
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Met Ser Glu Tyr Ile Arg Val Thr 
145                 150                 155                 160 


Glu Asp Glu Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly 
                165                 170                 175     


Thr Val Leu Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly 
            180                 185                 190         


Leu Arg Tyr Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu 
        195                 200                 205             


Val Glu Gly Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val 
    210                 215                 220                 


Tyr Val Val Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr 
225                 230                 235                 240 


Asp Ala Ser Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser 
                245                 250                 255     


Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu 
            260                 265                 270         


Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys 
        275                 280                 285             


Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe 
    290                 295                 300                 


Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile 
305                 310                 315                 320 


Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln 
                325                 330                 335     


Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu 
            340                 345                 350         


Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp 
        355                 360                 365             


Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val 
    370                 375                 380                 


Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu 
385                 390                 395                 400 


Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His 
                405                 410                 415     


Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro 
            420                 425                 430         


Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly 
        435                 440                 445             


Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn 
    450                 455                 460                 


Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala 
465                 470                 475                 480 


Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln 
                485                 490                 495     


Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln 
            500                 505                 510         


Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly 
        515                 520                 525             


Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly 
    530                 535                 540                 


Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys 
545                 550                 555                 560 


Ser Ser Gly Trp Gly Met Phe Ala Pro Val Ala Thr Met Val Ser Lys 
                565                 570                 575     


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
            580                 585                 590         


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
        595                 600                 605             


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
    610                 615                 620                 


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
625                 630                 635                 640 


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
                645                 650                 655     


Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
            660                 665                 670         


Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser 
        675                 680                 685             


Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr 
    690                 695                 700                 


Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
705                 710                 715                 720 


Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly 
                725                 730                 735     


Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala 
            740                 745                 750         


Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly 
        755                 760                 765             


Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
    770                 775                 780                 


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr 
785                 790                 795                 800 


Gly Gly Met Asp Glu Leu Tyr Lys 
                805             


<210>  35
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Lys 
225                 230                 235                 240 


Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
                245                 250                 255     


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            260                 265                 270         


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        275                 280                 285             


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    290                 295                 300                 


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
305                 310                 315                 320 


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                325                 330                 335     


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            340                 345                 350         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        355                 360                 365             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    370                 375                 380                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
385                 390                 395                 400 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                405                 410                 415     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            420                 425                 430         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        435                 440                 445             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    450                 455                 460                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
465                 470                 475                 480 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                485                 490                 495     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            500                 505                 510         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        515                 520                 525             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    530                 535                 540                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
545                 550                 555                 560 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                565                 570                 575     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            580                 585                 590         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        595                 600                 605             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    610                 615                 620                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
625                 630                 635                 640 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Phe Arg 
                645                 650                 655     


Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly 
            660                 665                 670         


Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly 
        675                 680                 685             


Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys 
    690                 695                 700                 


Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly 
705                 710                 715                 720 


Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser 
                725                 730                 735     


Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser 
            740                 745                 750         


Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val 
        755                 760                 765             


Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn 
    770                 775                 780                 


Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr 
785                 790                 795                 800 


Ser Met Gly Phe Gln Cys Glu Thr Glu 
                805                 


<210>  36
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Lys 
225                 230                 235                 240 


Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu 
                245                 250                 255     


Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys 
            260                 265                 270         


Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe 
        275                 280                 285             


Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile 
    290                 295                 300                 


Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln 
305                 310                 315                 320 


Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu 
                325                 330                 335     


Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp 
            340                 345                 350         


Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val 
        355                 360                 365             


Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu 
    370                 375                 380                 


Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His 
385                 390                 395                 400 


Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro 
                405                 410                 415     


Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly 
            420                 425                 430         


Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn 
        435                 440                 445             


Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala 
    450                 455                 460                 


Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln 
465                 470                 475                 480 


Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln 
                485                 490                 495     


Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly 
            500                 505                 510         


Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly 
        515                 520                 525             


Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys 
    530                 535                 540                 


Ser Ser Gly Trp Gly Met Phe Arg Ala Gln Arg His Thr Leu Tyr Ala 
545                 550                 555                 560 


Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg 
                565                 570                 575     


Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu 
            580                 585                 590         


Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser 
        595                 600                 605             


Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly 
    610                 615                 620                 


Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys 
625                 630                 635                 640 


Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys 
                645                 650                 655     


Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe Lys 
            660                 665                 670         


Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg 
        675                 680                 685             


Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr 
    690                 695                 700                 


Glu 
705 


<210>  37
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Lys 
225                 230                 235                 240 


Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu 
                245                 250                 255     


Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile 
            260                 265                 270         


Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln 
        275                 280                 285             


Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser 
    290                 295                 300                 


Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu 
305                 310                 315                 320 


Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln 
                325                 330                 335     


Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn 
            340                 345                 350         


Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile 
        355                 360                 365             


Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp 
    370                 375                 380                 


Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser 
385                 390                 395                 400 


Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala 
                405                 410                 415     


Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala 
            420                 425                 430         


Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn 
        435                 440                 445             


Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
    450                 455                 460                 


Phe Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
465                 470                 475                 480 


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
                485                 490                 495     


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
            500                 505                 510         


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
        515                 520                 525             


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
    530                 535                 540                 


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
545                 550                 555                 560 


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
                565                 570                 575     


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
            580                 585                 590         


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
        595                 600                 605             


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
    610                 615                 


<210>  38
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Lys 
225                 230                 235                 240 


Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe 
                245                 250                 255     


Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser 
            260                 265                 270         


Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala 
        275                 280                 285             


Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met 
    290                 295                 300                 


Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn 
305                 310                 315                 320 


Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser 
                325                 330                 335     


Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp 
            340                 345                 350         


Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe 
        355                 360                 365             


Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Phe Arg Ala 
    370                 375                 380                 


Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp 
385                 390                 395                 400 


Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro 
                405                 410                 415     


Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp 
            420                 425                 430         


Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr 
        435                 440                 445             


Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro 
    450                 455                 460                 


Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn 
465                 470                 475                 480 


Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln 
                485                 490                 495     


Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe 
            500                 505                 510         


Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser 
        515                 520                 525             


Met Gly Phe Gln Cys Glu Thr Glu 
    530                 535     


<210>  39
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Asp Leu Ile Val Leu Gly Leu Pro 
145                 150                 155                 160 


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
                165                 170                 175     


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
            180                 185                 190         


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
        195                 200                 205             


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
    210                 215                 220                 


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
225                 230                 235                 240 


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
                245                 250                 255     


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
            260                 265                 270         


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
        275                 280                 285             


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
    290                 295                 300                 


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
305                 310                 315                 320 


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
                325                 330                 335     


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            340                 345                 350         


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        355                 360                 365             


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    370                 375                 380                 


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
385                 390                 395                 400 


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                405                 410                 415     


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            420                 425                 430         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        435                 440                 445             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met Phe Ala 
    450                 455                 460                 


Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
465                 470                 475                 480 


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
                485                 490                 495     


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
            500                 505                 510         


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
        515                 520                 525             


Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala 
    530                 535                 540                 


Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe 
545                 550                 555                 560 


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
                565                 570                 575     


Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile 
            580                 585                 590         


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val 
        595                 600                 605             


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr 
    610                 615                 620                 


Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu 
625                 630                 635                 640 


Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala 
                645                 650                 655     


Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu 
            660                 665                 670         


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu 
        675                 680                 685             


Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
    690                 695                 700                 


<210>  40
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Arg Lys Val Phe Val Gly Arg Cys 
145                 150                 155                 160 


Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr 
                165                 170                 175     


Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala 
            180                 185                 190         


Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu 
        195                 200                 205             


Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro 
    210                 215                 220                 


Lys His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly 
225                 230                 235                 240 


Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly 
                245                 250                 255     


Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly 
            260                 265                 270         


Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala 
        275                 280                 285             


Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser 
    290                 295                 300                 


Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn 
305                 310                 315                 320 


Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr 
                325                 330                 335     


Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn 
            340                 345                 350         


Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp 
        355                 360                 365             


Ser Lys Ser Ser Gly Trp Gly Met Phe Ala Pro Val Ala Thr Met Val 
    370                 375                 380                 


Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg 
385                 390                 395                 400 


Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile 
                405                 410                 415     


Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys 
            420                 425                 430         


Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu 
        435                 440                 445             


Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala 
    450                 455                 460                 


Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp 
465                 470                 475                 480 


Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln 
                485                 490                 495     


Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg 
            500                 505                 510         


Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met 
        515                 520                 525             


Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu 
    530                 535                 540                 


Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr 
545                 550                 555                 560 


Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu 
                565                 570                 575     


Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn 
            580                 585                 590         


Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His 
        595                 600                 605             


Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
    610                 615             


<210>  41
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Gly Arg Phe Gly Gly Asn Pro Gly 
145                 150                 155                 160 


Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala 
                165                 170                 175     


Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe 
            180                 185                 190         


Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala 
        195                 200                 205             


Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn 
    210                 215                 220                 


Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg 
225                 230                 235                 240 


Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser 
                245                 250                 255     


Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser 
            260                 265                 270         


Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser 
        275                 280                 285             


Ser Gly Trp Gly Met Phe Ala Pro Val Ala Thr Met Val Ser Lys Gly 
    290                 295                 300                 


Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val 
305                 310                 315                 320 


His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
                325                 330                 335     


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
            340                 345                 350         


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
        355                 360                 365             


Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro 
    370                 375                 380                 


Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
385                 390                 395                 400 


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
                405                 410                 415     


Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn 
            420                 425                 430         


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
        435                 440                 445             


Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu 
    450                 455                 460                 


Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu 
465                 470                 475                 480 


Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala 
                485                 490                 495     


Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
            500                 505                 510         


Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly 
        515                 520                 525             


Gly Met Asp Glu Leu Tyr Lys 
    530                 535 


<210>  42
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu 
            500                 505                 510         


Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala 
        515                 520                 525             


Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys 
    530                 535                 540                 


Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu 
545                 550                 555                 560 


Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val 
                565                 570                 575     


Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly 
            580                 585                 590         


Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln 
        595                 600                 605             


Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr 
    610                 615                 620                 


Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
625                 630                 635                 


<210>  43
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Asp Pro Pro Val 
    130                 135                 140                 


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
                165                 170                 175     


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
            180                 185                 190         


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
        195                 200                 205             


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
    210                 215                 220                 


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
225                 230                 235                 240 


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
                245                 250                 255     


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
            260                 265                 270         


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
        275                 280                 285             


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
    290                 295                 300                 


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
305                 310                 315                 320 


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
                325                 330                 335     


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
            340                 345                 350         


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
        355                 360                 365             


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
    370                 375                 380                 


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
385                 390                 395                 400 


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
                405                 410                 415     


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
            420                 425                 430         


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
        435                 440                 445             


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
    450                 455                 460                 


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
465                 470                 475                 480 


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
                485                 490                 495     


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
            500                 505                 510         


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
        515                 520                 525             


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
    530                 535                 540                 


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
545                 550                 555                 560 


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
                565                 570                 575     


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
            580                 585                 590         


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
        595                 600                 605             


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
    610                 615                 620                 


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
625                 630                 635                 640 


Ile Gly Ala Ala 
                


<210>  44
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu 
            500                 505                 510         


Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala 
        515                 520                 525             


Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys 
    530                 535                 540                 


Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu 
545                 550                 555                 560 


Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val 
                565                 570                 575     


Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly 
            580                 585                 590         


Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln 
        595                 600                 605             


Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr 
    610                 615                 620                 


Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Asp 
625                 630                 635                 640 


Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala 
                645                 650                 655     


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
            660                 665                 670         


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
        675                 680                 685             


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
    690                 695                 700                 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
705                 710                 715                 720 


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
                725                 730                 735     


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
            740                 745                 750         


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
        755                 760                 765             


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
    770                 775                 780                 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
785                 790                 795                 800 


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
                805                 810                 815     


Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys 
            820                 825                 830         


Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys 
        835                 840                 845             


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
    850                 855                 860                 


Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr 
865                 870                 875                 880 


Lys 
    


<210>  45
<211>  882
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu 
            500                 505                 510         


Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
        515                 520                 525             


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
    530                 535                 540                 


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
545                 550                 555                 560 


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
                565                 570                 575     


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
            580                 585                 590         


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
        595                 600                 605             


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
    610                 615                 620                 


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
625                 630                 635                 640 


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
                645                 650                 655     


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
            660                 665                 670         


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
        675                 680                 685             


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
    690                 695                 700                 


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
705                 710                 715                 720 


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys Met Asp Val Phe Met Lys Gly Leu Ser Lys 
            740                 745                 750         


Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly Val 
        755                 760                 765             


Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser 
    770                 775                 780                 


Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys 
785                 790                 795                 800 


Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val 
                805                 810                 815     


Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala 
            820                 825                 830         


Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly 
        835                 840                 845             


Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn 
    850                 855                 860                 


Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro 
865                 870                 875                 880 


Glu Ala 
        


<210>  46
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Asp Pro Pro Val 
    130                 135                 140                 


Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly 
                165                 170                 175     


Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe 
            180                 185                 190         


Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His 
        195                 200                 205             


Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys 
    210                 215                 220                 


Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly 
225                 230                 235                 240 


Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val 
                245                 250                 255     


Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val 
            260                 265                 270         


Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys 
        275                 280                 285             


Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys 
    290                 295                 300                 


Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu 
305                 310                 315                 320 


Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu 
                325                 330                 335     


Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu 
            340                 345                 350         


Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn 
        355                 360                 365             


Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys 
    370                 375                 380                 


Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly 
385                 390                 395                 400 


Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile 
                405                 410                 415     


Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu 
            420                 425                 430         


Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe 
        435                 440                 445             


Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe 
    450                 455                 460                 


Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly 
465                 470                 475                 480 


Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala 
                485                 490                 495     


Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala 
            500                 505                 510         


Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp 
        515                 520                 525             


Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln 
    530                 535                 540                 


Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp 
545                 550                 555                 560 


Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile 
                565                 570                 575     


Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His 
            580                 585                 590         


His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu 
        595                 600                 605             


Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg 
    610                 615                 620                 


Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met 
625                 630                 635                 640 


Ile Gly Ala Ala Ala Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala 
                645                 650                 655     


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
            660                 665                 670         


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
        675                 680                 685             


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
    690                 695                 700                 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
705                 710                 715                 720 


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
                725                 730                 735     


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
            740                 745                 750         


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
        755                 760                 765             


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
    770                 775                 780                 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
785                 790                 795                 800 


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
                805                 810                 815     


Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys 
            820                 825                 830         


Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys 
        835                 840                 845             


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
    850                 855                 860                 


Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr 
865                 870                 875                 880 


Lys 
    


<210>  47
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Phe His Thr Leu 
    130                 135                 140                 


Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met 
145                 150                 155                 160 


Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys 
                165                 170                 175     


Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr 
            180                 185                 190         


Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val 
        195                 200                 205             


Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys 
    210                 215                 220                 


Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met 
225                 230                 235                 240 


Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn 
                245                 250                 255     


Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro 
            260                 265                 270         


Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys 
        275                 280                 285             


Glu Thr Glu 
    290     


<210>  48
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Met Asp Val Phe Met Lys Gly Leu 
145                 150                 155                 160 


Ser Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln 
                165                 170                 175     


Gly Val Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val 
            180                 185                 190         


Gly Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala 
        195                 200                 205             


Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr 
    210                 215                 220                 


Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu 
                245                 250                 255     


Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro 
            260                 265                 270         


Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr 
        275                 280                 285             


Glu Pro Glu Ala 
    290         


<210>  49
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Ser Lys Met Asp Val 
225                 230                 235                 240 


Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val Ala Ala Ala 
                245                 250                 255     


Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys Thr Lys Glu 
            260                 265                 270         


Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val Val His Gly 
        275                 280                 285             


Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly 
    290                 295                 300                 


Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu 
305                 310                 315                 320 


Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln 
                325                 330                 335     


Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp 
            340                 345                 350         


Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu 
        355                 360                 365             


Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Phe His Thr Leu Tyr Ala Pro 
    370                 375                 380                 


Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro 
385                 390                 395                 400 


Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile 
                405                 410                 415     


Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu 
            420                 425                 430         


Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg 
        435                 440                 445             


Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser 
    450                 455                 460                 


Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala 
465                 470                 475                 480 


Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe Lys Lys 
                485                 490                 495     


Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp 
            500                 505                 510         


Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu 
        515                 520                 525             


<210>  50
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
                245                 250                 255     


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
            260                 265                 270         


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
        275                 280                 285             


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
    290                 295                 300                 


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
305                 310                 315                 320 


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
                325                 330                 335     


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
            340                 345                 350         


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
        355                 360                 365             


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
    370                 375                 380                 


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Ala Leu Glu Phe Cys 
385                 390                 395                 400 


Ser Arg Arg Tyr Arg Gly Pro Met Asp Val Phe Met Lys Gly Leu Ser 
                405                 410                 415     


Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly 
            420                 425                 430         


Val Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly 
        435                 440                 445             


Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu 
    450                 455                 460                 


Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly 
465                 470                 475                 480 


Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala 
                485                 490                 495     


Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu 
            500                 505                 510         


Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp 
        515                 520                 525             


Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu 
    530                 535                 540                 


Pro Glu Ala 
545         


<210>  51
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
    130                 135                 140                 


Gly Phe Gln Cys Glu Thr Glu Ala Met Asp Val Phe Met Lys Gly Leu 
145                 150                 155                 160 


Ser Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln 
                165                 170                 175     


Gly Val Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val 
            180                 185                 190         


Gly Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala 
        195                 200                 205             


Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr 
    210                 215                 220                 


Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile 
225                 230                 235                 240 


Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu 
                245                 250                 255     


Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro 
            260                 265                 270         


Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr 
        275                 280                 285             


Glu Pro Glu Ala Phe Ala Pro Val Ala Thr Met Val Ser Lys Gly Glu 
    290                 295                 300                 


Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
305                 310                 315                 320 


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
                325                 330                 335     


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
            340                 345                 350         


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
        355                 360                 365             


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
    370                 375                 380                 


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
385                 390                 395                 400 


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
                405                 410                 415     


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
            420                 425                 430         


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
        435                 440                 445             


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
    450                 455                 460                 


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
465                 470                 475                 480 


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
                485                 490                 495     


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
            500                 505                 510         


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
        515                 520                 525             


Met Asp Glu Leu Tyr Lys 
    530                 


<210>  52
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Leu Leu Pro Val 
    130                 135                 140                 


Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys 
145                 150                 155                 160 


Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His 
                165                 170                 175     


Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr 
            180                 185                 190         


Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala 
        195                 200                 205             


Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val 
    210                 215                 220                 


Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu 
225                 230                 235                 240 


Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val 
                245                 250                 255     


Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys 
            260                 265                 270         


Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln 
        275                 280                 285             


Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu 
    290                 295                 300                 


Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp 
305                 310                 315                 320 


Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys 
                325                 330                 335     


Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile 
            340                 345                 350         


Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala 
        355                 360                 365             


Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly 
    370                 375                 380                 


Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala 
385                 390                 395                 400 


Gly Pro Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly 
                405                 410                 415     


Tyr Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly 
            420                 425                 430         


Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys 
        435                 440                 445             


Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly 
    450                 455                 460                 


Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser 
465                 470                 475                 480 


Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser 
                485                 490                 495     


Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val 
            500                 505                 510         


Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn 
        515                 520                 525             


Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr 
    530                 535                 540                 


Ser Met Gly Phe Gln Cys Glu Thr Glu Gly Ile His Arg Ile 
545                 550                 555             


<210>  53
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys 
                245                 250                 255     


Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu 
            260                 265                 270         


Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr 
        275                 280                 285             


Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys 
    290                 295                 300                 


Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala 
305                 310                 315                 320 


Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr 
                325                 330                 335     


Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro 
            340                 345                 350         


Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala 
        355                 360                 365             


Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    370                 375                 380                 


Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Met His Thr Leu Tyr 
385                 390                 395                 400 


Ala Pro Gly Gly Tyr Asp Ile Met Gly Tyr Leu Ile Gln Ile Met Asn 
                405                 410                 415     


Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala 
            420                 425                 430         


Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala 
        435                 440                 445             


Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu 
    450                 455                 460                 


Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro 
465                 470                 475                 480 


Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg 
                485                 490                 495     


Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe 
            500                 505                 510         


Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val 
        515                 520                 525             


Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu 
    530                 535                 540                 


Thr Glu Gly Ile His Arg Ile 
545                 550     


<210>  54
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro 
                245                 250                 255     


Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Tyr Leu 
            260                 265                 270         


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
        275                 280                 285             


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
    290                 295                 300                 


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
                325                 330                 335     


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
            340                 345                 350         


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
        355                 360                 365             


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
    370                 375                 380                 


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
385                 390                 395                 400 


Gly Phe Gln Cys Glu Thr Glu Gly Met Asp Val Phe Met Lys Gly Leu 
                405                 410                 415     


Ser Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln 
            420                 425                 430         


Gly Val Ala Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val 
        435                 440                 445             


Gly Ser Lys Thr Lys Glu Gly Val Val His Gly Val Ala Thr Val Ala 
    450                 455                 460                 


Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr 
465                 470                 475                 480 


Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile 
                485                 490                 495     


Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu 
            500                 505                 510         


Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro 
        515                 520                 525             


Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr 
    530                 535                 540                 


Glu Pro Glu Ala His Arg Ile 
545                 550     


<210>  55
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro 
                245                 250                 255     


Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
            260                 265                 270         


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
        275                 280                 285             


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
    290                 295                 300                 


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
                325                 330                 335     


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
            340                 345                 350         


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
        355                 360                 365             


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
    370                 375                 380                 


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
385                 390                 395                 400 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
                405                 410                 415     


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
            420                 425                 430         


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
        435                 440                 445             


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
    450                 455                 460                 


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
465                 470                 475                 480 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
                485                 490                 495     


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
            500                 505                 510         


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
        515                 520                 525             


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
    530                 535                 540                 


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
545                 550                 555                 560 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
                565                 570                 575     


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
            580                 585                 590         


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
        595                 600                 605             


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
    610                 615                 620                 


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
625                 630                 635                 640 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
                645                 650                 655     


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
            660                 665                 670         


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
        675                 680                 685             


Ser Ala Ser Leu Ala Lys Gln Gly Leu Gly Ile His Arg Ile 
    690                 695                 700         


<210>  56
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro 
                245                 250                 255     


Met Pro Asp Tyr Ser Leu Val Lys Ala Leu Gln Met Ala Gln Gln Asn 
            260                 265                 270         


Phe Val Ile Thr Asp Ala Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala 
        275                 280                 285             


Ser Arg Gly Phe Leu Thr Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu 
    290                 295                 300                 


Gly Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala 
305                 310                 315                 320 


Val Asp Lys Ile Arg Asn Ala Ile Thr Lys Gly Val Asp Thr Ser Val 
                325                 330                 335     


Cys Leu Leu Asn Tyr Arg Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe 
            340                 345                 350         


Phe Val Ala Gly Leu Arg Asp Ser Lys Gly Asn Ile Val Asn Tyr Val 
        355                 360                 365             


Gly Val Gln Ser Lys Val Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn 
    370                 375                 380                 


Glu Gln Asn Ile Glu Tyr Lys Gly Val Arg Thr Ser Asn Met Leu Arg 
385                 390                 395                 400 


Arg Lys Pro Gly Gly Ile His Arg Ile Met Ala Glu Pro Arg Gln Glu 
                405                 410                 415     


Phe Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg 
            420                 425                 430         


Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr 
        435                 440                 445             


Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly 
    450                 455                 460                 


Ser Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr 
465                 470                 475                 480 


Ala Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys 
                485                 490                 495     


Gln Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala 
            500                 505                 510         


Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala 
        515                 520                 525             


Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr 
    530                 535                 540                 


Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile 
545                 550                 555                 560 


Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn 
                565                 570                 575     


Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro 
            580                 585                 590         


Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser 
        595                 600                 605             


Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu 
    610                 615                 620                 


Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr 
625                 630                 635                 640 


Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro 
                645                 650                 655     


Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr 
            660                 665                 670         


Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn 
        675                 680                 685             


Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp 
    690                 695                 700                 


Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
705                 710                 715                 720 


Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn 
                725                 730                 735     


Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys 
            740                 745                 750         


Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn 
        755                 760                 765             


Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys 
    770                 775                 780                 


Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
785                 790                 795                 800 


Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His 
                805                 810                 815     


Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro 
            820                 825                 830         


Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln 
        835                 840                 845             


Gly Leu Ile Thr Asp His Asn Gln Pro Tyr His Ile Cys Arg Gly Phe 
    850                 855                 860                 


Thr Cys Phe Lys Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
865                 870                 875                 


<210>  57
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro 
                245                 250                 255     


Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
            260                 265                 270         


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
        275                 280                 285             


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
    290                 295                 300                 


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
                325                 330                 335     


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
            340                 345                 350         


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
        355                 360                 365             


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
    370                 375                 380                 


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met 
385                 390                 395                 400 


Gly Phe Gln Cys Glu Thr Glu Gly Met Ala Glu Pro Arg Gln Glu Phe 
                405                 410                 415     


Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys 
            420                 425                 430         


Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp 
        435                 440                 445             


Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser 
    450                 455                 460                 


Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala 
465                 470                 475                 480 


Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln 
                485                 490                 495     


Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu 
            500                 505                 510         


Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly 
        515                 520                 525             


His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly 
    530                 535                 540                 


Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala 
545                 550                 555                 560 


Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala 
                565                 570                 575     


Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser 
            580                 585                 590         


Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
        595                 600                 605             


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
    610                 615                 620                 


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
625                 630                 635                 640 


Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val 
                645                 650                 655     


Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu 
            660                 665                 670         


Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys 
        675                 680                 685             


Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn 
    690                 695                 700                 


Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro 
705                 710                 715                 720 


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
                725                 730                 735     


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
            740                 745                 750         


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
        755                 760                 765             


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
    770                 775                 780                 


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile 
785                 790                 795                 800 


Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
                805                 810                 815     


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
            820                 825                 830         


Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly 
        835                 840                 845             


Leu His Arg Ile 
    850         


<210>  58
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Thr 
225                 230                 235                 240 


Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
                245                 250                 255     


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            260                 265                 270         


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        275                 280                 285             


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    290                 295                 300                 


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
305                 310                 315                 320 


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                325                 330                 335     


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            340                 345                 350         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        355                 360                 365             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    370                 375                 380                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
385                 390                 395                 400 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                405                 410                 415     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            420                 425                 430         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        435                 440                 445             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    450                 455                 460                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
465                 470                 475                 480 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                485                 490                 495     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            500                 505                 510         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        515                 520                 525             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    530                 535                 540                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
545                 550                 555                 560 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                565                 570                 575     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            580                 585                 590         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        595                 600                 605             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    610                 615                 620                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
625                 630                 635                 640 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                645                 650                 655     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            660                 665                 670         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Arg Arg Ala Gln Arg His Thr 
        675                 680                 685             


Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile 
    690                 695                 700                 


Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser 
705                 710                 715                 720 


Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val 
                725                 730                 735     


Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu 
            740                 745                 750         


Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val 
        755                 760                 765             


Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr 
    770                 775                 780                 


Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val 
785                 790                 795                 800 


Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile 
                805                 810                 815     


Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln 
            820                 825                 830         


Cys Glu Thr Glu Ala Leu Glu Phe Cys Ser Arg Arg Tyr Arg Gly Pro 
        835                 840                 845             


Gly Ile His Arg Ile 
    850             


<210>  59
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
                245                 250                 255     


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
            260                 265                 270         


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
        275                 280                 285             


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
    290                 295                 300                 


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
305                 310                 315                 320 


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
                325                 330                 335     


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
            340                 345                 350         


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
        355                 360                 365             


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
    370                 375                 380                 


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Ala Leu Ala Met Ala 
385                 390                 395                 400 


Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly Thr Tyr 
                405                 410                 415     


Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp 
            420                 425                 430         


Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr 
        435                 440                 445             


Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala 
    450                 455                 460                 


Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val Asp Glu 
465                 470                 475                 480 


Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu Ile Pro 
                485                 490                 495     


Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu 
            500                 505                 510         


Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys 
        515                 520                 525             


Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp 
    530                 535                 540                 


Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln 
545                 550                 555                 560 


Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala 
                565                 570                 575     


Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg 
            580                 585                 590         


Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
        595                 600                 605             


Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
    610                 615                 620                 


Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg 
625                 630                 635                 640 


Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
                645                 650                 655     


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            660                 665                 670         


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        675                 680                 685             


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    690                 695                 700                 


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
705                 710                 715                 720 


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                725                 730                 735     


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            740                 745                 750         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        755                 760                 765             


Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr 
    770                 775                 780                 


Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp 
785                 790                 795                 800 


Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp 
                805                 810                 815     


Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala 
            820                 825                 830         


Ser Leu Ala Lys Gln Gly Leu Arg Cys Ser Arg Arg Tyr Arg Gly Pro 
        835                 840                 845             


Gly Ile His Arg Ile 
    850             


<210>  60
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Ala Leu Pro Val Ala Thr Met 
        435                 440                 445             


Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
    450                 455                 460                 


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
465                 470                 475                 480 


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
                485                 490                 495     


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
            500                 505                 510         


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
        515                 520                 525             


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
    530                 535                 540                 


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
545                 550                 555                 560 


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
                565                 570                 575     


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
            580                 585                 590         


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
        595                 600                 605             


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
    610                 615                 620                 


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
625                 630                 635                 640 


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
                645                 650                 655     


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
            660                 665                 670         


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser 
        675                 680                 685             


Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met 
    690                 695                 700                 


Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu 
705                 710                 715                 720 


Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln 
                725                 730                 735     


Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr 
            740                 745                 750         


Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln 
        755                 760                 765             


Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp 
    770                 775                 780                 


Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu 
785                 790                 795                 800 


Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val 
                805                 810                 815     


Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg 
            820                 825                 830         


Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Ala Leu Glu Phe Cys Ser 
        835                 840                 845             


Arg Arg Tyr Arg Gly Pro Gly Ile His Arg Ile 
    850                 855                 


<210>  61
<211>  1190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu 
            500                 505                 510         


Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
        515                 520                 525             


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
    530                 535                 540                 


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
545                 550                 555                 560 


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
                565                 570                 575     


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
            580                 585                 590         


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
        595                 600                 605             


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
    610                 615                 620                 


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
625                 630                 635                 640 


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
                645                 650                 655     


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
            660                 665                 670         


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
        675                 680                 685             


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
    690                 695                 700                 


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
705                 710                 715                 720 


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys Ser Arg Met Ala Glu Pro Arg Gln Glu Phe 
            740                 745                 750         


Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys 
        755                 760                 765             


Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp 
    770                 775                 780                 


Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser 
785                 790                 795                 800 


Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala 
                805                 810                 815     


Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln 
            820                 825                 830         


Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu 
        835                 840                 845             


Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly 
    850                 855                 860                 


His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly 
865                 870                 875                 880 


Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala 
                885                 890                 895     


Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala 
            900                 905                 910         


Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser 
        915                 920                 925             


Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
    930                 935                 940                 


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
945                 950                 955                 960 


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
                965                 970                 975     


Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val 
            980                 985                 990         


Pro Met Pro Asp Leu Lys Asn Val  Lys Ser Lys Ile Gly  Ser Thr Glu 
        995                 1000                 1005             


Asn Leu  Lys His Gln Pro Gly  Gly Gly Lys Val Gln  Ile Ile Asn 
    1010                 1015                 1020             


Lys Lys  Leu Asp Leu Ser Asn  Val Gln Ser Lys Cys  Gly Ser Lys 
    1025                 1030                 1035             


Asp Asn  Ile Lys His Val Pro  Gly Gly Gly Ser Val  Gln Ile Val 
    1040                 1045                 1050             


Tyr Lys  Pro Val Asp Leu Ser  Lys Val Thr Ser Lys  Cys Gly Ser 
    1055                 1060                 1065             


Leu Gly  Asn Ile His His Lys  Pro Gly Gly Gly Gln  Val Glu Val 
    1070                 1075                 1080             


Lys Ser  Glu Lys Leu Asp Phe  Lys Asp Arg Val Gln  Ser Lys Ile 
    1085                 1090                 1095             


Gly Ser  Leu Asp Asn Ile Thr  His Val Pro Gly Gly  Gly Asn Lys 
    1100                 1105                 1110             


Lys Ile  Glu Thr His Lys Leu  Thr Phe Arg Glu Asn  Ala Lys Ala 
    1115                 1120                 1125             


Lys Thr  Asp His Gly Ala Glu  Ile Val Tyr Lys Ser  Pro Val Val 
    1130                 1135                 1140             


Ser Gly  Asp Thr Ser Pro Arg  His Leu Ser Asn Val  Ser Ser Thr 
    1145                 1150                 1155             


Gly Ser  Ile Asp Met Val Asp  Ser Pro Gln Leu Ala  Thr Leu Ala 
    1160                 1165                 1170             


Asp Glu  Val Ser Ala Ser Leu  Ala Lys Gln Gly Leu  Gly Asp Ser 
    1175                 1180                 1185             


Arg Ser  
    1190 


<210>  62
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Phe Ala Thr Met Val Ser Lys 
        435                 440                 445             


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
    450                 455                 460                 


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
465                 470                 475                 480 


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
                485                 490                 495     


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
            500                 505                 510         


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
        515                 520                 525             


Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
    530                 535                 540                 


Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser 
545                 550                 555                 560 


Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr 
                565                 570                 575     


Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
            580                 585                 590         


Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly 
        595                 600                 605             


Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala 
    610                 615                 620                 


Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly 
625                 630                 635                 640 


Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
                645                 650                 655     


Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr 
            660                 665                 670         


Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg Ser Arg Ala Gln 
        675                 680                 685             


Ala Ser Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly Ser Thr Gly 
    690                 695                 700                 


Ser Arg 
705     


<210>  63
<211>  1193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Ala Leu Pro Asp Ser Asp Leu 
        435                 440                 445             


Glu Ala Thr Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg 
    450                 455                 460                 


Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu 
465                 470                 475                 480 


Gly Ser Val Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln 
                485                 490                 495     


Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala 
            500                 505                 510         


His Leu Ser Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile 
        515                 520                 525             


Lys Thr His Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr 
    530                 535                 540                 


Gly Ala Thr Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu 
545                 550                 555                 560 


Val Arg Asp His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser 
                565                 570                 575     


Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr 
            580                 585                 590         


Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys 
        595                 600                 605             


Cys Leu Asp Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg 
    610                 615                 620                 


Leu Met Pro Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile 
625                 630                 635                 640 


Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu 
                645                 650                 655     


Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu 
            660                 665                 670         


Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys 
        675                 680                 685             


Lys Val Val Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe 
    690                 695                 700                 


Gly Glu Ile Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln 
705                 710                 715                 720 


Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp 
                725                 730                 735     


Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys 
            740                 745                 750         


Phe Asn Phe Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg 
        755                 760                 765             


Phe Phe Pro Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln 
    770                 775                 780                 


Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp 
785                 790                 795                 800 


Ala Thr Gly Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe 
                805                 810                 815     


Ala Val Lys Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe 
            820                 825                 830         


Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp 
        835                 840                 845             


Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu 
    850                 855                 860                 


Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr 
865                 870                 875                 880 


Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile 
                885                 890                 895     


His His Pro Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val 
            900                 905                 910         


Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala 
        915                 920                 925             


Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile 
    930                 935                 940                 


Met Ile Gly Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser 
945                 950                 955                 960 


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
                965                 970                 975     


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
            980                 985                 990         


Gly Glu Gly Glu Gly Arg Pro Tyr  Glu Gly Thr Gln Thr  Ala Lys Leu 
        995                 1000                 1005             


Lys Val  Thr Lys Gly Gly Pro  Leu Pro Phe Ala Trp  Asp Ile Leu 
    1010                 1015                 1020             


Ser Pro  Gln Phe Met Tyr Gly  Ser Lys Ala Tyr Val  Lys His Pro 
    1025                 1030                 1035             


Ala Asp  Ile Pro Asp Tyr Leu  Lys Leu Ser Phe Pro  Glu Gly Phe 
    1040                 1045                 1050             


Lys Trp  Glu Arg Val Met Asn  Phe Glu Asp Gly Gly  Val Val Thr 
    1055                 1060                 1065             


Val Thr  Gln Asp Ser Ser Leu  Gln Asp Gly Glu Phe  Ile Tyr Lys 
    1070                 1075                 1080             


Val Lys  Leu Arg Gly Thr Asn  Phe Pro Ser Asp Gly  Pro Val Met 
    1085                 1090                 1095             


Gln Lys  Lys Thr Met Gly Trp  Glu Ala Ser Ser Glu  Arg Met Tyr 
    1100                 1105                 1110             


Pro Glu  Asp Gly Ala Leu Lys  Gly Glu Ile Lys Gln  Arg Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Gly Gly His Tyr  Asp Ala Glu Val Lys  Thr Thr Tyr 
    1130                 1135                 1140             


Lys Ala  Lys Lys Pro Val Gln  Leu Pro Gly Ala Tyr  Asn Val Asn 
    1145                 1150                 1155             


Ile Lys  Leu Asp Ile Thr Ser  His Asn Glu Asp Tyr  Thr Ile Val 
    1160                 1165                 1170             


Glu Gln  Tyr Glu Arg Ala Glu  Gly Arg His Ser Thr  Gly Gly Met 
    1175                 1180                 1185             


Asp Glu  Leu Tyr Lys 
    1190             


<210>  64
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Pro Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            500                 505                 510         


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        515                 520                 525             


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    530                 535                 540                 


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
545                 550                 555                 560 


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
                565                 570                 575     


Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln 
            580                 585                 590         


Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
        595                 600                 605             


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
    610                 615                 620                 


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
625                 630                 635                 640 


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
                645                 650                 655     


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
            660                 665                 670         


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
        675                 680                 685             


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
    690                 695                 700                 


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
705                 710                 715                 720 


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
                725                 730                 735     


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
            740                 745                 750         


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
        755                 760                 765             


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
    770                 775                 780                 


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
785                 790                 795                 800 


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                805                 810                 815     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            820                 825                 830         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        835                 840                 845             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    850                 855                 860                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
865                 870                 875                 880 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                885                 890                 895     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            900                 905                 910         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        915                 920                 925             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu Gly Asp Pro 
    930                 935                 940                 


Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
945                 950                 955                 960 


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
                965                 970                 975     


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
            980                 985                 990         


Gly Thr Gln Thr Ala Lys Leu Lys  Val Thr Lys Gly Gly  Pro Leu Pro 
        995                 1000                 1005             


Phe Ala  Trp Asp Ile Leu Ser  Pro Gln Phe Met Tyr  Gly Ser Lys 
    1010                 1015                 1020             


Ala Tyr  Val Lys His Pro Ala  Asp Ile Pro Asp Tyr  Leu Lys Leu 
    1025                 1030                 1035             


Ser Phe  Pro Glu Gly Phe Lys  Trp Glu Arg Val Met  Asn Phe Glu 
    1040                 1045                 1050             


Asp Gly  Gly Val Val Thr Val  Thr Gln Asp Ser Ser  Leu Gln Asp 
    1055                 1060                 1065             


Gly Glu  Phe Ile Tyr Lys Val  Lys Leu Arg Gly Thr  Asn Phe Pro 
    1070                 1075                 1080             


Ser Asp  Gly Pro Val Met Gln  Lys Lys Thr Met Gly  Trp Glu Ala 
    1085                 1090                 1095             


Ser Ser  Glu Arg Met Tyr Pro  Glu Asp Gly Ala Leu  Lys Gly Glu 
    1100                 1105                 1110             


Ile Lys  Gln Arg Leu Lys Leu  Lys Asp Gly Gly His  Tyr Asp Ala 
    1115                 1120                 1125             


Glu Val  Lys Thr Thr Tyr Lys  Ala Lys Lys Pro Val  Gln Leu Pro 
    1130                 1135                 1140             


Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp Ile Thr  Ser His Asn 
    1145                 1150                 1155             


Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu Arg Ala  Glu Gly Arg 
    1160                 1165                 1170             


His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr Lys 
    1175                 1180                 


<210>  65
<211>  1190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu 
            500                 505                 510         


Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His 
        515                 520                 525             


Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly 
    530                 535                 540                 


Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr 
545                 550                 555                 560 


Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe 
                565                 570                 575     


Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp 
            580                 585                 590         


Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met 
        595                 600                 605             


Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu 
    610                 615                 620                 


Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe 
625                 630                 635                 640 


Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala 
                645                 650                 655     


Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile 
            660                 665                 670         


Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val 
        675                 680                 685             


Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr 
    690                 695                 700                 


Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr 
705                 710                 715                 720 


Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys Ser Arg Met Ala Glu Pro Arg Gln Glu Phe 
            740                 745                 750         


Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys 
        755                 760                 765             


Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp 
    770                 775                 780                 


Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser 
785                 790                 795                 800 


Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala 
                805                 810                 815     


Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln 
            820                 825                 830         


Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu 
        835                 840                 845             


Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly 
    850                 855                 860                 


His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly 
865                 870                 875                 880 


Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala 
                885                 890                 895     


Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala 
            900                 905                 910         


Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser 
        915                 920                 925             


Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
    930                 935                 940                 


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
945                 950                 955                 960 


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
                965                 970                 975     


Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val 
            980                 985                 990         


Pro Met Pro Asp Leu Lys Asn Val  Lys Ser Lys Ile Gly  Ser Thr Glu 
        995                 1000                 1005             


Asn Leu  Lys His Gln Pro Gly  Gly Gly Lys Val Gln  Ile Ile Asn 
    1010                 1015                 1020             


Lys Lys  Leu Asp Leu Ser Asn  Val Gln Ser Lys Cys  Gly Ser Lys 
    1025                 1030                 1035             


Asp Asn  Ile Lys His Val Pro  Gly Gly Gly Ser Val  Gln Ile Val 
    1040                 1045                 1050             


Tyr Lys  Pro Val Asp Leu Ser  Lys Val Thr Ser Lys  Cys Gly Ser 
    1055                 1060                 1065             


Leu Gly  Asn Ile His His Lys  Pro Gly Gly Gly Gln  Val Glu Val 
    1070                 1075                 1080             


Lys Ser  Glu Lys Leu Asp Phe  Lys Asp Arg Val Gln  Ser Lys Ile 
    1085                 1090                 1095             


Gly Ser  Leu Asp Asn Ile Thr  His Val Pro Gly Gly  Gly Asn Lys 
    1100                 1105                 1110             


Lys Ile  Glu Thr His Lys Leu  Thr Phe Arg Glu Asn  Ala Lys Ala 
    1115                 1120                 1125             


Lys Thr  Asp His Gly Ala Glu  Ile Val Tyr Lys Ser  Pro Val Val 
    1130                 1135                 1140             


Ser Gly  Asp Thr Ser Pro Arg  His Leu Ser Asn Val  Ser Ser Thr 
    1145                 1150                 1155             


Gly Ser  Ile Asp Met Val Asp  Ser Pro Gln Leu Ala  Thr Leu Ala 
    1160                 1165                 1170             


Asp Glu  Val Ser Ala Ser Leu  Ala Lys Gln Gly Leu  Gly Asp Ser 
    1175                 1180                 1185             


Arg Ser  
    1190 


<210>  66
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Thr 
225                 230                 235                 240 


Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
                245                 250                 255     


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            260                 265                 270         


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        275                 280                 285             


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    290                 295                 300                 


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
305                 310                 315                 320 


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                325                 330                 335     


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            340                 345                 350         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        355                 360                 365             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    370                 375                 380                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
385                 390                 395                 400 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                405                 410                 415     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            420                 425                 430         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        435                 440                 445             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    450                 455                 460                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
465                 470                 475                 480 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                485                 490                 495     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            500                 505                 510         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        515                 520                 525             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    530                 535                 540                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
545                 550                 555                 560 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                565                 570                 575     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            580                 585                 590         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        595                 600                 605             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    610                 615                 620                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
625                 630                 635                 640 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                645                 650                 655     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            660                 665                 670         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Arg Arg Ala Gln Arg His Thr 
        675                 680                 685             


Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile 
    690                 695                 700                 


Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser 
705                 710                 715                 720 


Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val 
                725                 730                 735     


Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu 
            740                 745                 750         


Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val 
        755                 760                 765             


Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr 
    770                 775                 780                 


Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val Glu Val Val 
785                 790                 795                 800 


Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile 
                805                 810                 815     


Pro Val Arg Asp Glu Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln 
            820                 825                 830         


Cys Glu Thr Glu Ala Leu Glu Phe Cys Ser Arg Arg Tyr Arg Gly Pro 
        835                 840                 845             


Gly Ile His Arg Ile 
    850             


<210>  67
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Leu Arg 
225                 230                 235                 240 


Ser Arg Ala Gln Arg His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile 
                245                 250                 255     


Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu 
            260                 265                 270         


Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys 
        275                 280                 285             


Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met 
    290                 295                 300                 


Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu 
305                 310                 315                 320 


Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val 
                325                 330                 335     


Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala 
            340                 345                 350         


Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe 
        355                 360                 365             


Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Tyr 
    370                 375                 380                 


Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Ala Leu Ala Met Ala 
385                 390                 395                 400 


Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly Thr Tyr 
                405                 410                 415     


Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp 
            420                 425                 430         


Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr 
        435                 440                 445             


Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala 
    450                 455                 460                 


Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val Asp Glu 
465                 470                 475                 480 


Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu Ile Pro 
                485                 490                 495     


Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu 
            500                 505                 510         


Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys 
        515                 520                 525             


Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp 
    530                 535                 540                 


Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln 
545                 550                 555                 560 


Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala 
                565                 570                 575     


Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg 
            580                 585                 590         


Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
        595                 600                 605             


Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
    610                 615                 620                 


Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg 
625                 630                 635                 640 


Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
                645                 650                 655     


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            660                 665                 670         


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        675                 680                 685             


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    690                 695                 700                 


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
705                 710                 715                 720 


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                725                 730                 735     


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            740                 745                 750         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        755                 760                 765             


Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr 
    770                 775                 780                 


Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp 
785                 790                 795                 800 


Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp 
                805                 810                 815     


Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala 
            820                 825                 830         


Ser Leu Ala Lys Gln Gly Leu Arg Cys Ser Arg Arg Tyr Arg Gly Pro 
        835                 840                 845             


Gly Ile His Arg Ile 
    850             


<210>  68
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            500                 505                 510         


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        515                 520                 525             


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    530                 535                 540                 


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
545                 550                 555                 560 


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
                565                 570                 575     


Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln 
            580                 585                 590         


Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
        595                 600                 605             


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
    610                 615                 620                 


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
625                 630                 635                 640 


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
                645                 650                 655     


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
            660                 665                 670         


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
        675                 680                 685             


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
    690                 695                 700                 


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
705                 710                 715                 720 


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
                725                 730                 735     


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
            740                 745                 750         


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
        755                 760                 765             


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
    770                 775                 780                 


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
785                 790                 795                 800 


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                805                 810                 815     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            820                 825                 830         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        835                 840                 845             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    850                 855                 860                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
865                 870                 875                 880 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                885                 890                 895     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            900                 905                 910         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        915                 920                 925             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu Ala Thr Leu 
    930                 935                 940                 


Asp His Asn Gln Pro Tyr His Ile Cys Arg Gly Phe Thr Cys Phe Lys 
945                 950                 955                 960 


Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
                965                 970     


<210>  69
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69

Met His Thr Leu Tyr Ala Pro Gly Gly Tyr Asp Ile Met Gly Trp Leu 
1               5                   10                  15      


Ile Gln Ile Met Asn Arg Pro Asn Pro Gln Val Glu Leu Gly Pro Val 
            20                  25                  30          


Asp Thr Ser Cys Ala Leu Ile Leu Cys Asp Leu Lys Gln Lys Asp Thr 
        35                  40                  45              


Pro Ile Val Tyr Ala Ser Glu Ala Phe Leu Tyr Met Thr Gly Tyr Ser 
    50                  55                  60                  


Asn Ala Glu Val Leu Gly Arg Asn Cys Arg Phe Leu Gln Ser Pro Asp 
65                  70                  75                  80  


Gly Met Val Lys Pro Lys Ser Thr Arg Lys Tyr Val Asp Ser Asn Thr 
                85                  90                  95      


Ile Asn Thr Met Arg Lys Ala Ile Asp Arg Asn Ala Glu Val Gln Val 
            100                 105                 110         


Glu Val Val Asn Phe Lys Lys Asn Gly Gln Arg Phe Val Asn Phe Leu 
        115                 120                 125             


Thr Met Ile Pro Val Arg Asp Glu Thr Gly Glu Met Ala Glu Pro Arg 
    130                 135                 140                 


Gln Glu Phe Glu Val Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly 
145                 150                 155                 160 


Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly 
                165                 170                 175     


Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu 
            180                 185                 190         


Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr 
        195                 200                 205             


Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro 
    210                 215                 220                 


Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr 
225                 230                 235                 240 


Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu 
                245                 250                 255     


Ala Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp 
            260                 265                 270         


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr 
        275                 280                 285             


Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln 
    290                 295                 300                 


Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr 
305                 310                 315                 320 


Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr 
                325                 330                 335     


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
            340                 345                 350         


Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
        355                 360                 365             


Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr 
    370                 375                 380                 


Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly 
385                 390                 395                 400 


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
                405                 410                 415     


Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser 
            420                 425                 430         


Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val 
        435                 440                 445             


Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu 
    450                 455                 460                 


Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser 
465                 470                 475                 480 


Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu 
                485                 490                 495     


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr 
            500                 505                 510         


His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly 
        515                 520                 525             


Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro 
    530                 535                 540                 


Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp 
545                 550                 555                 560 


Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala 
                565                 570                 575     


Lys Gln Gly Leu His Arg Ile 
            580             


<210>  70
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Met Lys Met Asp Lys Lys Thr 
        435                 440                 445             


Ile Val Trp Phe Arg Arg Asp Leu Arg Ile Glu Asp Asn Pro Ala Leu 
    450                 455                 460                 


Ala Ala Ala Ala His Glu Gly Ser Val Phe Pro Val Phe Ile Trp Cys 
465                 470                 475                 480 


Pro Glu Glu Glu Gly Gln Phe Tyr Pro Gly Arg Ala Ser Arg Trp Trp 
                485                 490                 495     


Met Lys Gln Ser Leu Ala His Leu Ser Gln Ser Leu Lys Ala Leu Gly 
            500                 505                 510         


Ser Asp Leu Thr Leu Ile Lys Thr His Asn Thr Ile Ser Ala Ile Leu 
        515                 520                 525             


Asp Cys Ile Arg Val Thr Gly Ala Thr Lys Val Val Phe Asn His Leu 
    530                 535                 540                 


Tyr Asp Pro Val Ser Leu Val Arg Asp His Thr Val Lys Glu Lys Leu 
545                 550                 555                 560 


Val Glu Arg Gly Ile Ser Val Gln Ser Tyr Asn Gly Asp Leu Leu Tyr 
                565                 570                 575     


Glu Pro Trp Glu Ile Tyr Cys Glu Lys Gly Lys Pro Phe Thr Ser Phe 
            580                 585                 590         


Asn Ser Tyr Trp Lys Lys Cys Leu Asp Met Ser Ile Glu Ser Val Met 
        595                 600                 605             


Leu Pro Pro Pro Trp Arg Leu Met Pro Ile Thr Ala Ala Ala Glu Ala 
    610                 615                 620                 


Ile Trp Ala Cys Ser Ile Glu Glu Leu Gly Leu Glu Asn Glu Ala Glu 
625                 630                 635                 640 


Lys Pro Ser Asn Ala Leu Leu Thr Arg Ala Trp Ser Pro Gly Trp Ser 
                645                 650                 655     


Asn Ala Asp Lys Leu Leu Asn Glu Phe Ile Glu Lys Gln Leu Ile Asp 
            660                 665                 670         


Tyr Ala Lys Asn Ser Lys Lys Val Val Gly Asn Ser Thr Ser Leu Leu 
        675                 680                 685             


Ser Pro Tyr Leu His Phe Gly Glu Ile Ser Val Arg His Val Phe Gln 
    690                 695                 700                 


Cys Ala Arg Met Lys Gln Ile Ile Trp Ala Arg Asp Lys Asn Ser Glu 
705                 710                 715                 720 


Gly Glu Glu Ser Ala Asp Leu Phe Leu Arg Gly Ile Gly Leu Arg Glu 
                725                 730                 735     


Tyr Ser Arg Tyr Ile Cys Phe Asn Phe Pro Phe Thr His Glu Gln Ser 
            740                 745                 750         


Leu Leu Ser His Leu Arg Phe Phe Pro Trp Asp Ala Asp Val Asp Lys 
        755                 760                 765             


Phe Lys Ala Trp Arg Gln Gly Arg Thr Gly Tyr Pro Leu Val Asp Ala 
    770                 775                 780                 


Gly Met Arg Glu Leu Trp Ala Thr Gly Trp Met His Asn Arg Ile Arg 
785                 790                 795                 800 


Val Ile Val Ser Ser Phe Ala Val Lys Phe Leu Leu Leu Pro Trp Lys 
                805                 810                 815     


Trp Gly Met Lys Tyr Phe Trp Asp Thr Leu Leu Asp Ala Asp Leu Glu 
            820                 825                 830         


Cys Asp Ile Leu Gly Trp Gln Tyr Ile Ser Gly Ser Ile Pro Asp Gly 
        835                 840                 845             


His Glu Leu Asp Arg Leu Asp Asn Pro Ala Leu Gln Gly Ala Lys Tyr 
    850                 855                 860                 


Asp Pro Glu Gly Glu Tyr Ile Arg Gln Trp Leu Pro Glu Leu Ala Arg 
865                 870                 875                 880 


Leu Pro Thr Glu Trp Ile His His Pro Trp Asp Ala Pro Leu Thr Val 
                885                 890                 895     


Leu Lys Ala Ser Gly Val Glu Leu Gly Thr Asn Tyr Ala Lys Pro Ile 
            900                 905                 910         


Val Asp Ile Asp Thr Ala Arg Glu Leu Leu Ala Lys Ala Ile Ser Arg 
        915                 920                 925             


Thr Arg Gly Ala Gln Ile Met Ile Gly Ala Ala Ala Thr Leu Asp His 
    930                 935                 940                 


Asn Gln Pro Tyr His Ile Cys Arg Gly Phe Thr Cys Phe Lys Lys Pro 
945                 950                 955                 960 


Pro Thr Pro Pro Pro Glu Pro Glu Thr 
                965                 


<210>  71
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu Pro Asp Tyr Ser Leu Val Lys 
        435                 440                 445             


Ala Leu Gln Met Ala Gln Gln Asn Phe Val Ile Thr Asp Ala Ser Leu 
    450                 455                 460                 


Pro Asp Asn Pro Ile Val Tyr Ala Ser Arg Gly Phe Leu Thr Leu Thr 
465                 470                 475                 480 


Gly Tyr Ser Leu Asp Gln Ile Leu Gly Arg Asn Cys Arg Phe Leu Gln 
                485                 490                 495     


Gly Pro Glu Thr Asp Pro Arg Ala Val Asp Lys Ile Arg Asn Ala Ile 
            500                 505                 510         


Thr Lys Gly Val Asp Thr Ser Val Cys Leu Leu Asn Tyr Arg Gln Asp 
        515                 520                 525             


Gly Thr Thr Phe Trp Asn Leu Phe Phe Val Ala Gly Leu Arg Asp Ser 
    530                 535                 540                 


Lys Gly Asn Ile Val Asn Tyr Val Gly Val Gln Ser Lys Val Ser Glu 
545                 550                 555                 560 


Asp Tyr Ala Lys Leu Leu Val Asn Glu Gln Asn Ile Glu Tyr Lys Gly 
                565                 570                 575     


Val Arg Thr Ser Asn Met Leu Arg Arg Lys Pro Gly Leu Gln Ser Thr 
            580                 585                 590         


Val Pro Arg Ala Arg Asp Pro Pro Asp Leu Asp Asn 
        595                 600                 


<210>  72
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu His Thr Leu Tyr Ala Pro Gly 
        435                 440                 445             


Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn 
    450                 455                 460                 


Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu 
465                 470                 475                 480 


Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala 
                485                 490                 495     


Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn 
            500                 505                 510         


Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr 
        515                 520                 525             


Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile 
    530                 535                 540                 


Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn 
545                 550                 555                 560 


Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu 
                565                 570                 575     


Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Leu 
            580                 585                 590         


Gln Ser Thr Val Pro Arg Ala Arg Asp Pro Pro Asp Leu Asp Asn 
        595                 600                 605         


<210>  73
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu His Thr Leu Tyr Ala Pro Gly 
        435                 440                 445             


Gly Tyr Asp Ile Met Gly Trp Leu Ile Gln Ile Met Asn Arg Pro Asn 
    450                 455                 460                 


Pro Gln Val Glu Leu Gly Pro Val Asp Thr Ser Cys Ala Leu Ile Leu 
465                 470                 475                 480 


Cys Asp Leu Lys Gln Lys Asp Thr Pro Ile Val Tyr Ala Ser Glu Ala 
                485                 490                 495     


Phe Leu Tyr Met Thr Gly Tyr Ser Asn Ala Glu Val Leu Gly Arg Asn 
            500                 505                 510         


Cys Arg Phe Leu Gln Ser Pro Asp Gly Met Val Lys Pro Lys Ser Thr 
        515                 520                 525             


Arg Lys Tyr Val Asp Ser Asn Thr Ile Asn Thr Met Arg Lys Ala Ile 
    530                 535                 540                 


Asp Arg Asn Ala Glu Val Gln Val Glu Val Val Asn Phe Lys Lys Asn 
545                 550                 555                 560 


Gly Gln Arg Phe Val Asn Phe Leu Thr Met Ile Pro Val Arg Asp Glu 
                565                 570                 575     


Thr Gly Glu Tyr Arg Tyr Ser Met Gly Phe Gln Cys Glu Thr Glu Leu 
            580                 585                 590         


Gln Ser Thr Val Pro Arg Ala Arg Asp Pro Pro Asp Leu Asp Asn 
        595                 600                 605         


<210>  74
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74

Met Pro Asp Tyr Ser Leu Val Lys Ala Leu Gln Met Ala Gln Gln Asn 
1               5                   10                  15      


Phe Val Ile Thr Asp Ala Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala 
            20                  25                  30          


Ser Arg Gly Phe Leu Thr Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu 
        35                  40                  45              


Gly Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala 
    50                  55                  60                  


Val Asp Lys Ile Arg Asn Ala Ile Thr Lys Gly Val Asp Thr Ser Val 
65                  70                  75                  80  


Cys Leu Leu Asn Tyr Arg Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe 
                85                  90                  95      


Phe Val Ala Gly Leu Arg Asp Ser Lys Gly Asn Ile Val Asn Tyr Val 
            100                 105                 110         


Gly Val Gln Ser Lys Val Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn 
        115                 120                 125             


Glu Gln Asn Ile Glu Tyr Lys Gly Val Arg Thr Ser Asn Met Leu Arg 
    130                 135                 140                 


Arg Lys Pro Gly Ser Leu Met Ala Glu Pro Arg Gln Glu Phe Glu Val 
145                 150                 155                 160 


Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln 
                165                 170                 175     


Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly 
            180                 185                 190         


Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu 
        195                 200                 205             


Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp 
    210                 215                 220                 


Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala 
225                 230                 235                 240 


Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala 
                245                 250                 255     


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
            260                 265                 270         


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
        275                 280                 285             


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
    290                 295                 300                 


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
305                 310                 315                 320 


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
                325                 330                 335     


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
            340                 345                 350         


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
        355                 360                 365             


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
    370                 375                 380                 


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
385                 390                 395                 400 


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
                405                 410                 415     


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
            420                 425                 430         


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
        435                 440                 445             


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
    450                 455                 460                 


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
465                 470                 475                 480 


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
                485                 490                 495     


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
            500                 505                 510         


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
        515                 520                 525             


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
    530                 535                 540                 


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
545                 550                 555                 560 


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
                565                 570                 575     


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu Ser 
            580                 585                 590         


Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly Ser Thr Gly Ser Arg 
        595                 600                 605             


<210>  75
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  75

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu 
            500                 505                 510         


Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu 
        515                 520                 525             


Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr 
    530                 535                 540                 


Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly 
545                 550                 555                 560 


Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val 
                565                 570                 575     


Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser 
            580                 585                 590         


Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile 
        595                 600                 605             


Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr 
    610                 615                 620                 


Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu 
625                 630                 635                 640 


Lys Thr Gly His Ser Lys Gly Leu Gly Phe Val Arg Phe Thr Glu Tyr 
                645                 650                 655     


Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg 
            660                 665                 670         


Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro 
        675                 680                 685             


Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr 
    690                 695                 700                 


Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp 
705                 710                 715                 720 


Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala 
                725                 730                 735     


Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys 
            740                 745                 750         


Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn 
        755                 760                 765             


Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe 
    770                 775                 780                 


Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu 
785                 790                 795                 800 


Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala 
                805                 810                 815     


Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln 
            820                 825                 830         


Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser 
        835                 840                 845             


Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro 
    850                 855                 860                 


Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser 
                885                 890                 895     


Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly 
            900                 905                 910         


Trp Gly Met Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        915                 920                 925             


Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val 
    930                 935                 940                 


His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
945                 950                 955                 960 


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
                965                 970                 975     


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
            980                 985                 990         


Phe Met Tyr Gly Ser Lys Ala Tyr  Val Lys His Pro Ala  Asp Ile Pro 
        995                 1000                 1005             


Asp Tyr  Leu Lys Leu Ser Phe  Pro Glu Gly Phe Lys  Trp Glu Arg 
    1010                 1015                 1020             


Val Met  Asn Phe Glu Asp Gly  Gly Val Val Thr Val  Thr Gln Asp 
    1025                 1030                 1035             


Ser Ser  Leu Gln Asp Gly Glu  Phe Ile Tyr Lys Val  Lys Leu Arg 
    1040                 1045                 1050             


Gly Thr  Asn Phe Pro Ser Asp  Gly Pro Val Met Gln  Lys Lys Thr 
    1055                 1060                 1065             


Met Gly  Trp Glu Ala Ser Ser  Glu Arg Met Tyr Pro  Glu Asp Gly 
    1070                 1075                 1080             


Ala Leu  Lys Gly Glu Ile Lys  Gln Arg Leu Lys Leu  Lys Asp Gly 
    1085                 1090                 1095             


Gly His  Tyr Asp Ala Glu Val  Lys Thr Thr Tyr Lys  Ala Lys Lys 
    1100                 1105                 1110             


Pro Val  Gln Leu Pro Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp 
    1115                 1120                 1125             


Ile Thr  Ser His Asn Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu 
    1130                 1135                 1140             


Arg Ala  Glu Gly Arg His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr 
    1145                 1150                 1155             


Lys 
    


<210>  76
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Arg Gly Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu 
            500                 505                 510         


Asn Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu 
        515                 520                 525             


Leu Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr 
    530                 535                 540                 


Arg Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly 
545                 550                 555                 560 


Ile Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val 
                565                 570                 575     


Asn Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser 
            580                 585                 590         


Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile 
        595                 600                 605             


Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr 
    610                 615                 620                 


Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu 
625                 630                 635                 640 


Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr 
                645                 650                 655     


Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg 
            660                 665                 670         


Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro 
        675                 680                 685             


Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr 
    690                 695                 700                 


Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp 
705                 710                 715                 720 


Val Phe Ile Pro Lys Pro Phe Arg Ala Leu Ala Phe Val Thr Phe Ala 
                725                 730                 735     


Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys 
            740                 745                 750         


Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn 
        755                 760                 765             


Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe 
    770                 775                 780                 


Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu 
785                 790                 795                 800 


Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala 
                805                 810                 815     


Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln 
            820                 825                 830         


Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser 
        835                 840                 845             


Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro 
    850                 855                 860                 


Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser 
865                 870                 875                 880 


Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser 
                885                 890                 895     


Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly 
            900                 905                 910         


Trp Gly Met Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly 
        915                 920                 925             


Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val 
    930                 935                 940                 


His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
945                 950                 955                 960 


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
                965                 970                 975     


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
            980                 985                 990         


Phe Met Tyr Gly Ser Lys Ala Tyr  Val Lys His Pro Ala  Asp Ile Pro 
        995                 1000                 1005             


Asp Tyr  Leu Lys Leu Ser Phe  Pro Glu Gly Phe Lys  Trp Glu Arg 
    1010                 1015                 1020             


Val Met  Asn Phe Glu Asp Gly  Gly Val Val Thr Val  Thr Gln Asp 
    1025                 1030                 1035             


Ser Ser  Leu Gln Asp Gly Glu  Phe Ile Tyr Lys Val  Lys Leu Arg 
    1040                 1045                 1050             


Gly Thr  Asn Phe Pro Ser Asp  Gly Pro Val Met Gln  Lys Lys Thr 
    1055                 1060                 1065             


Met Gly  Trp Glu Ala Ser Ser  Glu Arg Met Tyr Pro  Glu Asp Gly 
    1070                 1075                 1080             


Ala Leu  Lys Gly Glu Ile Lys  Gln Arg Leu Lys Leu  Lys Asp Gly 
    1085                 1090                 1095             


Gly His  Tyr Asp Ala Glu Val  Lys Thr Thr Tyr Lys  Ala Lys Lys 
    1100                 1105                 1110             


Pro Val  Gln Leu Pro Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp 
    1115                 1120                 1125             


Ile Thr  Ser His Asn Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu 
    1130                 1135                 1140             


Arg Ala  Glu Gly Arg His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr 
    1145                 1150                 1155             


Lys 
    


<210>  77
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  77

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
    770                 775                 780                 


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
785                 790                 795                 800 


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
                805                 810                 815     


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
            820                 825                 830         


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
        835                 840                 845             


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
    850                 855                 860                 


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
865                 870                 875                 880 


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
                885                 890                 895     


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ala Ala Gly Trp 
            900                 905                 910         


Gly Met Trp Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        915                 920                 925             


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
    930                 935                 940                 


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
945                 950                 955                 960 


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
                965                 970                 975     


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
            980                 985                 990         


Tyr Gly Ser Lys Ala Tyr Val Lys  His Pro Ala Asp Ile  Pro Asp Tyr 
        995                 1000                 1005             


Leu Lys  Leu Ser Phe Pro Glu  Gly Phe Lys Trp Glu  Arg Val Met 
    1010                 1015                 1020             


Asn Phe  Glu Asp Gly Gly Val  Val Thr Val Thr Gln  Asp Ser Ser 
    1025                 1030                 1035             


Leu Gln  Asp Gly Glu Phe Ile  Tyr Lys Val Lys Leu  Arg Gly Thr 
    1040                 1045                 1050             


Asn Phe  Pro Ser Asp Gly Pro  Val Met Gln Lys Lys  Thr Met Gly 
    1055                 1060                 1065             


Trp Glu  Ala Ser Ser Glu Arg  Met Tyr Pro Glu Asp  Gly Ala Leu 
    1070                 1075                 1080             


Lys Gly  Glu Ile Lys Gln Arg  Leu Lys Leu Lys Asp  Gly Gly His 
    1085                 1090                 1095             


Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys Ala Lys  Lys Pro Val 
    1100                 1105                 1110             


Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile Lys Leu  Asp Ile Thr 
    1115                 1120                 1125             


Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu Gln Tyr  Glu Arg Ala 
    1130                 1135                 1140             


Glu Gly  Arg His Ser Thr Gly  Gly Met Asp Glu Leu  Tyr Lys 
    1145                 1150                 1155         


<210>  78
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
    770                 775                 780                 


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
785                 790                 795                 800 


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
                805                 810                 815     


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
            820                 825                 830         


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
        835                 840                 845             


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
    850                 855                 860                 


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
865                 870                 875                 880 


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
                885                 890                 895     


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Asp Asp Gly Trp 
            900                 905                 910         


Gly Met Trp Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        915                 920                 925             


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
    930                 935                 940                 


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
945                 950                 955                 960 


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
                965                 970                 975     


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
            980                 985                 990         


Tyr Gly Ser Lys Ala Tyr Val Lys  His Pro Ala Asp Ile  Pro Asp Tyr 
        995                 1000                 1005             


Leu Lys  Leu Ser Phe Pro Glu  Gly Phe Lys Trp Glu  Arg Val Met 
    1010                 1015                 1020             


Asn Phe  Glu Asp Gly Gly Val  Val Thr Val Thr Gln  Asp Ser Ser 
    1025                 1030                 1035             


Leu Gln  Asp Gly Glu Phe Ile  Tyr Lys Val Lys Leu  Arg Gly Thr 
    1040                 1045                 1050             


Asn Phe  Pro Ser Asp Gly Pro  Val Met Gln Lys Lys  Thr Met Gly 
    1055                 1060                 1065             


Trp Glu  Ala Ser Ser Glu Arg  Met Tyr Pro Glu Asp  Gly Ala Leu 
    1070                 1075                 1080             


Lys Gly  Glu Ile Lys Gln Arg  Leu Lys Leu Lys Asp  Gly Gly His 
    1085                 1090                 1095             


Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys Ala Lys  Lys Pro Val 
    1100                 1105                 1110             


Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile Lys Leu  Asp Ile Thr 
    1115                 1120                 1125             


Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu Gln Tyr  Glu Arg Ala 
    1130                 1135                 1140             


Glu Gly  Arg His Ser Thr Gly  Gly Met Asp Glu Leu  Tyr Lys 
    1145                 1150                 1155         


<210>  79
<211>  1156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  79

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
    770                 775                 780                 


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
785                 790                 795                 800 


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
                805                 810                 815     


Ser Ile Asn Pro Val Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
            820                 825                 830         


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
        835                 840                 845             


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
    850                 855                 860                 


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
865                 870                 875                 880 


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
                885                 890                 895     


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp 
            900                 905                 910         


Gly Trp Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp 
        915                 920                 925             


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
    930                 935                 940                 


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
945                 950                 955                 960 


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
                965                 970                 975     


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
            980                 985                 990         


Gly Ser Lys Ala Tyr Val Lys His  Pro Ala Asp Ile Pro  Asp Tyr Leu 
        995                 1000                 1005             


Lys Leu  Ser Phe Pro Glu Gly  Phe Lys Trp Glu Arg  Val Met Asn 
    1010                 1015                 1020             


Phe Glu  Asp Gly Gly Val Val  Thr Val Thr Gln Asp  Ser Ser Leu 
    1025                 1030                 1035             


Gln Asp  Gly Glu Phe Ile Tyr  Lys Val Lys Leu Arg  Gly Thr Asn 
    1040                 1045                 1050             


Phe Pro  Ser Asp Gly Pro Val  Met Gln Lys Lys Thr  Met Gly Trp 
    1055                 1060                 1065             


Glu Ala  Ser Ser Glu Arg Met  Tyr Pro Glu Asp Gly  Ala Leu Lys 
    1070                 1075                 1080             


Gly Glu  Ile Lys Gln Arg Leu  Lys Leu Lys Asp Gly  Gly His Tyr 
    1085                 1090                 1095             


Asp Ala  Glu Val Lys Thr Thr  Tyr Lys Ala Lys Lys  Pro Val Gln 
    1100                 1105                 1110             


Leu Pro  Gly Ala Tyr Asn Val  Asn Ile Lys Leu Asp  Ile Thr Ser 
    1115                 1120                 1125             


His Asn  Glu Asp Tyr Thr Ile  Val Glu Gln Tyr Glu  Arg Ala Glu 
    1130                 1135                 1140             


Gly Arg  His Ser Thr Gly Gly  Met Asp Glu Leu Tyr  Lys 
    1145                 1150                 1155     


<210>  80
<211>  1156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
    770                 775                 780                 


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
785                 790                 795                 800 


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
                805                 810                 815     


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
            820                 825                 830         


Ser Trp Gly Met Val Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
        835                 840                 845             


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
    850                 855                 860                 


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
865                 870                 875                 880 


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
                885                 890                 895     


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp 
            900                 905                 910         


Gly Trp Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp 
        915                 920                 925             


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
    930                 935                 940                 


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
945                 950                 955                 960 


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
                965                 970                 975     


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
            980                 985                 990         


Gly Ser Lys Ala Tyr Val Lys His  Pro Ala Asp Ile Pro  Asp Tyr Leu 
        995                 1000                 1005             


Lys Leu  Ser Phe Pro Glu Gly  Phe Lys Trp Glu Arg  Val Met Asn 
    1010                 1015                 1020             


Phe Glu  Asp Gly Gly Val Val  Thr Val Thr Gln Asp  Ser Ser Leu 
    1025                 1030                 1035             


Gln Asp  Gly Glu Phe Ile Tyr  Lys Val Lys Leu Arg  Gly Thr Asn 
    1040                 1045                 1050             


Phe Pro  Ser Asp Gly Pro Val  Met Gln Lys Lys Thr  Met Gly Trp 
    1055                 1060                 1065             


Glu Ala  Ser Ser Glu Arg Met  Tyr Pro Glu Asp Gly  Ala Leu Lys 
    1070                 1075                 1080             


Gly Glu  Ile Lys Gln Arg Leu  Lys Leu Lys Asp Gly  Gly His Tyr 
    1085                 1090                 1095             


Asp Ala  Glu Val Lys Thr Thr  Tyr Lys Ala Lys Lys  Pro Val Gln 
    1100                 1105                 1110             


Leu Pro  Gly Ala Tyr Asn Val  Asn Ile Lys Leu Asp  Ile Thr Ser 
    1115                 1120                 1125             


His Asn  Glu Asp Tyr Thr Ile  Val Glu Gln Tyr Glu  Arg Ala Glu 
    1130                 1135                 1140             


Gly Arg  His Ser Thr Gly Gly  Met Asp Glu Leu Tyr  Lys 
    1145                 1150                 1155     


<210>  81
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
            500                 505                 510         


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
        515                 520                 525             


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
    530                 535                 540                 


Ile Asn Pro Val Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
545                 550                 555                 560 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
                565                 570                 575     


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
            580                 585                 590         


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
        595                 600                 605             


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
    610                 615                 620                 


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
625                 630                 635                 640 


Met Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp 
                645                 650                 655     


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
            660                 665                 670         


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
        675                 680                 685             


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
    690                 695                 700                 


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
705                 710                 715                 720 


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
                725                 730                 735     


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
            740                 745                 750         


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
        755                 760                 765             


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
    770                 775                 780                 


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
785                 790                 795                 800 


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
                805                 810                 815     


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
            820                 825                 830         


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
        835                 840                 845             


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
    850                 855                 860                 


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
865                 870                 875                 880 


Glu Leu Tyr Lys 
                


<210>  82
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
            500                 505                 510         


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
        515                 520                 525             


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
    530                 535                 540                 


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
545                 550                 555                 560 


Trp Gly Met Val Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
                565                 570                 575     


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
            580                 585                 590         


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
        595                 600                 605             


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
    610                 615                 620                 


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
625                 630                 635                 640 


Met Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp 
                645                 650                 655     


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
            660                 665                 670         


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
        675                 680                 685             


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
    690                 695                 700                 


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
705                 710                 715                 720 


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
                725                 730                 735     


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
            740                 745                 750         


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
        755                 760                 765             


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
    770                 775                 780                 


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
785                 790                 795                 800 


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
                805                 810                 815     


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
            820                 825                 830         


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
        835                 840                 845             


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
    850                 855                 860                 


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
865                 870                 875                 880 


Glu Leu Tyr Lys 
                


<210>  83
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
            500                 505                 510         


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
        515                 520                 525             


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
    530                 535                 540                 


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
545                 550                 555                 560 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
                565                 570                 575     


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
            580                 585                 590         


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
        595                 600                 605             


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
    610                 615                 620                 


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ala Ala Gly Trp Gly 
625                 630                 635                 640 


Met Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp 
                645                 650                 655     


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
            660                 665                 670         


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
        675                 680                 685             


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
    690                 695                 700                 


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
705                 710                 715                 720 


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
                725                 730                 735     


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
            740                 745                 750         


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
        755                 760                 765             


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
    770                 775                 780                 


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
785                 790                 795                 800 


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
                805                 810                 815     


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
            820                 825                 830         


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
        835                 840                 845             


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
    850                 855                 860                 


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
865                 870                 875                 880 


Glu Leu Tyr Lys 
                


<210>  84
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Pro Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
            500                 505                 510         


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
        515                 520                 525             


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
    530                 535                 540                 


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
545                 550                 555                 560 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
                565                 570                 575     


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
            580                 585                 590         


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
        595                 600                 605             


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
    610                 615                 620                 


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Asp Asp Gly Trp Gly 
625                 630                 635                 640 


Met Thr Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
                645                 650                 655     


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
            660                 665                 670         


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
        675                 680                 685             


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
    690                 695                 700                 


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
705                 710                 715                 720 


Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr 
                725                 730                 735     


Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 
            740                 745                 750         


Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln 
        755                 760                 765             


Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro 
    770                 775                 780                 


Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 
785                 790                 795                 800 


Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys 
                805                 810                 815     


Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys 
            820                 825                 830         


Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn 
        835                 840                 845             


Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile 
    850                 855                 860                 


Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met 
865                 870                 875                 880 


Asp Glu Leu Tyr Lys 
                885 


<210>  85
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Leu Gly Leu Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Leu Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Leu Ala Leu Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly 
    770                 775                 780                 


Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly 
785                 790                 795                 800 


Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe 
                805                 810                 815     


Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser 
            820                 825                 830         


Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly 
        835                 840                 845             


Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn 
    850                 855                 860                 


Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly 
865                 870                 875                 880 


Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly 
                885                 890                 895     


Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp 
            900                 905                 910         


Gly Met Trp Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
        915                 920                 925             


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
    930                 935                 940                 


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
945                 950                 955                 960 


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
                965                 970                 975     


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
            980                 985                 990         


Tyr Gly Ser Lys Ala Tyr Val Lys  His Pro Ala Asp Ile  Pro Asp Tyr 
        995                 1000                 1005             


Leu Lys  Leu Ser Phe Pro Glu  Gly Phe Lys Trp Glu  Arg Val Met 
    1010                 1015                 1020             


Asn Phe  Glu Asp Gly Gly Val  Val Thr Val Thr Gln  Asp Ser Ser 
    1025                 1030                 1035             


Leu Gln  Asp Gly Glu Phe Ile  Tyr Lys Val Lys Leu  Arg Gly Thr 
    1040                 1045                 1050             


Asn Phe  Pro Ser Asp Gly Pro  Val Met Gln Lys Lys  Thr Met Gly 
    1055                 1060                 1065             


Trp Glu  Ala Ser Ser Glu Arg  Met Tyr Pro Glu Asp  Gly Ala Leu 
    1070                 1075                 1080             


Lys Gly  Glu Ile Lys Gln Arg  Leu Lys Leu Lys Asp  Gly Gly His 
    1085                 1090                 1095             


Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys Ala Lys  Lys Pro Val 
    1100                 1105                 1110             


Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile Lys Leu  Asp Ile Thr 
    1115                 1120                 1125             


Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu Gln Tyr  Glu Arg Ala 
    1130                 1135                 1140             


Glu Gly  Arg His Ser Thr Gly  Gly Met Asp Glu Leu  Tyr Lys 
    1145                 1150                 1155         


<210>  86
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr 
            500                 505                 510         


Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met 
        515                 520                 525             


Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly 
    530                 535                 540                 


Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln 
545                 550                 555                 560 


Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser 
                565                 570                 575     


Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Asp Pro Pro Val Ala 
            580                 585                 590         


Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
        595                 600                 605             


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
    610                 615                 620                 


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
625                 630                 635                 640 


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
                645                 650                 655     


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
            660                 665                 670         


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
        675                 680                 685             


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
    690                 695                 700                 


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
705                 710                 715                 720 


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
                725                 730                 735     


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
            740                 745                 750         


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
        755                 760                 765             


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
    770                 775                 780                 


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
785                 790                 795                 800 


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
                805                 810                 815     


Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
            820                 825                 


<210>  87
<211>  815
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met 
            500                 505                 510         


Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met 
        515                 520                 525             


Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe 
    530                 535                 540                 


Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile 
545                 550                 555                 560 


Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Arg Asp Pro Pro 
                565                 570                 575     


Val Ala Thr Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile 
            580                 585                 590         


Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly 
        595                 600                 605             


His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly 
    610                 615                 620                 


Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe 
625                 630                 635                 640 


Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr 
                645                 650                 655     


Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro 
            660                 665                 670         


Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val 
        675                 680                 685             


Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr 
    690                 695                 700                 


Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met 
705                 710                 715                 720 


Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro 
                725                 730                 735     


Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys 
            740                 745                 750         


Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys 
        755                 760                 765             


Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp 
    770                 775                 780                 


Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg 
785                 790                 795                 800 


Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815 


<210>  88
<211>  901
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr 
            500                 505                 510         


Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met 
        515                 520                 525             


Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly 
    530                 535                 540                 


Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln 
545                 550                 555                 560 


Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser 
                565                 570                 575     


Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly 
            580                 585                 590         


Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser 
        595                 600                 605             


Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala 
    610                 615                 620                 


Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys 
625                 630                 635                 640 


Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala 
                645                 650                 655     


Glu Pro Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
            660                 665                 670         


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
        675                 680                 685             


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
    690                 695                 700                 


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
705                 710                 715                 720 


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
                725                 730                 735     


Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr 
            740                 745                 750         


Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 
        755                 760                 765             


Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln 
    770                 775                 780                 


Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro 
785                 790                 795                 800 


Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 
                805                 810                 815     


Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys 
            820                 825                 830         


Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys 
        835                 840                 845             


Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn 
    850                 855                 860                 


Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile 
865                 870                 875                 880 


Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met 
                885                 890                 895     


Asp Glu Leu Tyr Lys 
            900     


<210>  89
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn 
            500                 505                 510         


Asp Glu Pro Ile Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu 
        515                 520                 525             


Ser Thr Val Thr Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg 
    530                 535                 540                 


Asn Pro Val Ser Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile 
545                 550                 555                 560 


Leu His Ala Pro Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
                565                 570                 575     


Tyr Pro Lys Asp Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser 
            580                 585                 590         


Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val 
        595                 600                 605             


Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe 
    610                 615                 620                 


Ser Thr Phe Gly Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys 
625                 630                 635                 640 


Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu 
                645                 650                 655     


Thr Gln Val Lys Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp 
            660                 665                 670         


Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu 
        675                 680                 685             


Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu 
    690                 695                 700                 


Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val 
705                 710                 715                 720 


Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp 
                725                 730                 735     


Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly 
            740                 745                 750         


Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg 
        755                 760                 765             


Gln Leu Glu Arg Ser Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys 
    770                 775                 780                 


Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys 
785                 790                 795                 800 


Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly 
                805                 810                 815     


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
            820                 825                 830         


Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro 
        835                 840                 845             


Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile 
    850                 855                 860                 


Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
865                 870                 875                 880 


Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser 
                885                 890                 895     


Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr 
            900                 905                 910         


Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
        915                 920                 925             


Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly 
    930                 935                 940                 


Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala 
945                 950                 955                 960 


Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly 
                965                 970                 975     


Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
            980                 985                 990         


Tyr Thr Ile Val Glu Gln Tyr Glu  Arg Ala Glu Gly Arg  His Ser Thr 
        995                 1000                 1005             


Gly Gly  Met Asp Glu Leu Tyr  Lys 
    1010                 1015     


<210>  90
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Cys Arg Ala Thr Met Tyr Pro Tyr Asp Val Pro Asp 
            500                 505                 510         


Tyr Ala Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr 
        515                 520                 525             


Gly Ala Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser 
    530                 535                 540                 


Gln Pro Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp 
545                 550                 555                 560 


Thr Ser Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln 
                565                 570                 575     


Asn Thr Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr 
            580                 585                 590         


Gly Gly Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln 
        595                 600                 605             


Ser Ser Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser 
    610                 615                 620                 


Gly Ser Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln 
625                 630                 635                 640 


Ser Gly Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser 
                645                 650                 655     


Tyr Gly Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln 
            660                 665                 670         


Asn Gln Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        675                 680                 685             


Gly Asn Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly 
705                 710                 715                 720 


Gly Tyr Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly 
                725                 730                 735     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly 
            740                 745                 750         


Tyr Glu Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met 
        755                 760                 765             


Gly Gly Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp 
    770                 775                 780                 


Gln Gly Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr 
785                 790                 795                 800 


Ile Phe Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala 
                805                 810                 815     


Asp Tyr Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly 
            820                 825                 830         


Gln Pro Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys 
        835                 840                 845             


Gly Glu Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala 
    850                 855                 860                 


Ile Asp Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val 
865                 870                 875                 880 


Ser Phe Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly 
                885                 890                 895     


Arg Gly Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly 
            900                 905                 910         


Gly Gly Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly 
        915                 920                 925             


Gly Gly Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn 
    930                 935                 940                 


Pro Thr Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln 
945                 950                 955                 960 


Cys Lys Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser 
                965                 970                 975     


His Met Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly 
            980                 985                 990         


Tyr Asp Arg Gly Gly Tyr Arg Gly  Arg Gly Gly Asp Arg  Gly Gly Phe 
        995                 1000                 1005             


Arg Gly  Gly Arg Gly Gly Gly  Asp Arg Gly Gly Phe  Gly Pro Gly 
    1010                 1015                 1020             


Lys Met  Asp Ser Arg Gly Glu  His Arg Gln Asp Arg  Arg Glu Arg 
    1025                 1030                 1035             


Pro Tyr  
    1040 


<210>  91
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Gly Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Ala Gln Cys Arg Ala Thr Met Tyr Pro Tyr Asp Val Pro Asp 
            500                 505                 510         


Tyr Ala Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr 
        515                 520                 525             


Gly Ala Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser 
    530                 535                 540                 


Gln Pro Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp 
545                 550                 555                 560 


Thr Ser Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln 
                565                 570                 575     


Asn Thr Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr 
            580                 585                 590         


Gly Gly Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln 
        595                 600                 605             


Ser Ser Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser 
    610                 615                 620                 


Gly Ser Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln 
625                 630                 635                 640 


Ser Gly Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser 
                645                 650                 655     


Tyr Gly Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln 
            660                 665                 670         


Asn Gln Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        675                 680                 685             


Gly Asn Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly 
705                 710                 715                 720 


Gly Tyr Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly 
                725                 730                 735     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly 
            740                 745                 750         


Tyr Glu Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met 
        755                 760                 765             


Gly Gly Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp 
    770                 775                 780                 


Gln Gly Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr 
785                 790                 795                 800 


Ile Phe Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala 
                805                 810                 815     


Asp Tyr Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly 
            820                 825                 830         


Gln Pro Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys 
        835                 840                 845             


Gly Glu Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala 
    850                 855                 860                 


Ile Asp Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val 
865                 870                 875                 880 


Ser Phe Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly 
                885                 890                 895     


Arg Gly Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly 
            900                 905                 910         


Gly Gly Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly 
        915                 920                 925             


Gly Gly Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn 
    930                 935                 940                 


Pro Thr Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln 
945                 950                 955                 960 


Cys Lys Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser 
                965                 970                 975     


His Met Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly 
            980                 985                 990         


Tyr Asp Arg Gly Gly Tyr Arg Gly  Arg Gly Gly Asp Arg  Gly Gly Phe 
        995                 1000                 1005             


Arg Gly  Gly Arg Gly Gly Gly  Asp Arg Gly Gly Phe  Gly Pro Gly 
    1010                 1015                 1020             


Lys Met  Asp Ser Arg Gly Glu  His Arg Gln Asp Arg  Arg Glu Arg 
    1025                 1030                 1035             


Pro Tyr  Trp Asp Pro Pro Val  Ala Thr Met Val Ser  Lys Gly Glu 
    1040                 1045                 1050             


Glu Asp  Asn Met Ala Ile Ile  Lys Glu Phe Met Arg  Phe Lys Val 
    1055                 1060                 1065             


His Met  Glu Gly Ser Val Asn  Gly His Glu Phe Glu  Ile Glu Gly 
    1070                 1075                 1080             


Glu Gly  Glu Gly Arg Pro Tyr  Glu Gly Thr Gln Thr  Ala Lys Leu 
    1085                 1090                 1095             


Lys Val  Thr Lys Gly Gly Pro  Leu Pro Phe Ala Trp  Asp Ile Leu 
    1100                 1105                 1110             


Ser Pro  Gln Phe Met Tyr Gly  Ser Lys Ala Tyr Val  Lys His Pro 
    1115                 1120                 1125             


Ala Asp  Ile Pro Asp Tyr Leu  Lys Leu Ser Phe Pro  Glu Gly Phe 
    1130                 1135                 1140             


Lys Trp  Glu Arg Val Met Asn  Phe Glu Asp Gly Gly  Val Val Thr 
    1145                 1150                 1155             


Val Thr  Gln Asp Ser Ser Leu  Gln Asp Gly Glu Phe  Ile Tyr Lys 
    1160                 1165                 1170             


Val Lys  Leu Arg Gly Thr Asn  Phe Pro Ser Asp Gly  Pro Val Met 
    1175                 1180                 1185             


Gln Lys  Lys Thr Met Gly Trp  Glu Ala Ser Ser Glu  Arg Met Tyr 
    1190                 1195                 1200             


Pro Glu  Asp Gly Ala Leu Lys  Gly Glu Ile Lys Gln  Arg Leu Lys 
    1205                 1210                 1215             


Leu Lys  Asp Gly Gly His Tyr  Asp Ala Glu Val Lys  Thr Thr Tyr 
    1220                 1225                 1230             


Lys Ala  Lys Lys Pro Val Gln  Leu Pro Gly Ala Tyr  Asn Val Asn 
    1235                 1240                 1245             


Ile Lys  Leu Asp Ile Thr Ser  His Asn Glu Asp Tyr  Thr Ile Val 
    1250                 1255                 1260             


Glu Gln  Tyr Glu Arg Ala Glu  Gly Arg His Ser Thr  Gly Gly Met 
    1265                 1270                 1275             


Asp Glu  Leu Tyr Lys 
    1280             


<210>  92
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92

Met Asn Gly Leu Thr Pro Pro Leu Met Phe Cys Ser Arg Ser Asp Asp 
1               5                   10                  15      


Pro Ser Ser Thr Ser Asn Ile Asn Leu Asp Asp Val Phe Ala Asp Val 
            20                  25                  30          


Phe Phe Asn Ser Asn Gly Glu Leu Leu Asp Ile Asp Glu Ile Asp Asp 
        35                  40                  45              


Phe Gly Asp Asn Thr Cys Pro Lys Ser Ser Met Ser Val Asp Asp Asp 
    50                  55                  60                  


Ala Ser Ser Gln Val Phe Gln Gly His Leu Phe Gly Asn Ala Leu Ser 
65                  70                  75                  80  


Ser Ile Ala Leu Ser Asp Ser Gly Asp Leu Ser Thr Gly Ile Tyr Glu 
                85                  90                  95      


Ser Gln Gly Asn Ala Ser Arg Gly Lys Ser Leu Arg Thr Lys Ser Ser 
            100                 105                 110         


Gly Ser Ile Ser Ser Glu Leu Thr Glu Ala Gln Lys Val Glu Arg Arg 
        115                 120                 125             


Glu Arg Asn Arg Glu His Ala Lys Arg Ser Arg Val Arg Lys Lys Phe 
    130                 135                 140                 


Leu Leu Glu Ser Leu Gln Gln Ser Val Asn Glu Leu Asn His Glu Asn 
145                 150                 155                 160 


Asn Cys Leu Lys Glu Ser Ile Arg Glu His Leu Gly Pro Arg Gly Asp 
                165                 170                 175     


Ser Leu Ile Ala Gln Cys Ser Pro Glu Ala Asp Thr Leu Leu Thr Asp 
            180                 185                 190         


Asn Pro Ser Lys Ala Asn Arg Ile Leu Glu Asp Pro Asp Tyr Ser Leu 
        195                 200                 205             


Val Lys Ala Leu Gln Met Ala Gln Gln Asn Phe Val Ile Thr Asp Ala 
    210                 215                 220                 


Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala Ser Arg Gly Phe Leu Thr 
225                 230                 235                 240 


Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu Gly Arg Asn Cys Arg Phe 
                245                 250                 255     


Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala Val Asp Lys Ile Arg Asn 
            260                 265                 270         


Ala Ile Thr Lys Gly Val Asp Thr Ser Val Cys Leu Leu Asn Tyr Arg 
        275                 280                 285             


Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe Phe Val Ala Gly Leu Arg 
    290                 295                 300                 


Asp Ser Lys Gly Asn Ile Val Asn Tyr Val Gly Val Gln Ser Lys Val 
305                 310                 315                 320 


Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn Glu Gln Asn Ile Glu Tyr 
                325                 330                 335     


Lys Gly Val Arg Thr Ser Asn Met Leu Arg Arg Lys 
            340                 345             


<210>  93
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93

Pro Asp Tyr Ser Leu Val Lys Ala Leu Gln Met Ala Gln Gln Asn Phe 
1               5                   10                  15      


Val Ile Thr Asp Ala Ser Leu Pro Asp Asn Pro Ile Val Tyr Ala Ser 
            20                  25                  30          


Arg Gly Phe Leu Thr Leu Thr Gly Tyr Ser Leu Asp Gln Ile Leu Gly 
        35                  40                  45              


Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Pro Arg Ala Val 
    50                  55                  60                  


Asp Lys Ile Arg Asn Ala Ile Thr Lys Gly Val Asp Thr Ser Val Cys 
65                  70                  75                  80  


Leu Leu Asn Tyr Arg Gln Asp Gly Thr Thr Phe Trp Asn Leu Phe Phe 
                85                  90                  95      


Val Ala Gly Leu Arg Asp Ser Lys Gly Asn Ile Val Asn Tyr Val Gly 
            100                 105                 110         


Val Gln Ser Lys Val Ser Glu Asp Tyr Ala Lys Leu Leu Val Asn Glu 
        115                 120                 125             


Gln Asn Ile Glu Tyr Lys Gly Val Arg Thr Ser Asn Met Leu Arg Arg 
    130                 135                 140                 


Lys 
145 


<210>  94
<211>  435
<212>  DNA
<213>  VfAU1-LOV domain (No Start codon)

<400>  94
cctgactaca gtctcgtgaa ggctctgcaa atggcacaac agaattttgt cattacagac       60

gcctccctcc cagacaaccc tatcgtctac gccagtagag ggtttctgac actgacaggc      120

tattctctcg accagatcct gggcaggaac tgcaggtttc tgcaagggcc agaaacagac      180

ccaagagctg tggataagat caggaatgcc atcaccaaag gcgttgatac cagtgtctgt      240

ctgctgaatt atagacagga tggcacaacc ttctggaatc tcttcttcgt ggctggactc      300

agagattcta agggcaatat tgtcaactac gtcggagtgc agtcaaaggt gagcgaagat      360

tatgccaagc tgctggtcaa cgagcagaac attgagtaca aaggtgtgcg caccagtaac      420

atgctgcgca gaaag                                                       435


<210>  95
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  96
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96

Met Asp Leu Ile Val Leu Gly Leu Pro Trp Lys Thr Thr Glu Gln Asp 
1               5                   10                  15      


Leu Lys Glu Tyr Phe Ser Thr Phe Gly Glu Val Leu Met Val Gln Val 
            20                  25                  30          


Lys Lys Asp Leu Lys Thr Gly His Ser Lys Gly Phe Gly Phe Val Arg 
        35                  40                  45              


Phe Thr Glu Tyr Glu Thr Gln Val Lys Val Met Ser Gln Arg His Met 
    50                  55                  60                  


Ile Asp Gly Arg Trp Cys Asp Cys Lys Leu Pro Asn Ser Lys Gln Ser 
65                  70                  75                  80  


Gln Asp Glu Pro Leu Arg Ser Arg Lys Val Phe Val Gly Arg Cys Thr 
                85                  90                  95      


Glu Asp Met Thr Glu Asp Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly 
            100                 105                 110         


Asp Val Met Asp Val Phe Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe 
        115                 120                 125             


Val Thr Phe Ala Asp Asp Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp 
    130                 135                 140                 


Leu Ile Ile Lys Gly Ile Ser Val His Ile Ser Asn Ala Glu Pro Lys 
145                 150                 155                 160 


His Asn Ser Asn Arg Gln Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn 
                165                 170                 175     


Pro Gly Gly Phe Gly Asn Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly 
            180                 185                 190         


Gly Ala Gly Leu Gly Asn Asn Gln Gly Ser Asn Met Gly Gly Gly Met 
        195                 200                 205             


Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met Met Ala Ala Ala Gln 
    210                 215                 220                 


Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly Met Leu Ala Ser Gln 
225                 230                 235                 240 


Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln Asn Gln Gly Asn Met 
                245                 250                 255     


Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser 
            260                 265                 270         


Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala 
        275                 280                 285             


Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp Ser 
    290                 295                 300                 


Lys Ser Ser Gly Trp Gly Met 
305                 310     


<210>  97
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97

Met Arg Lys Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp 
1               5                   10                  15      


Glu Leu Arg Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe 
            20                  25                  30          


Ile Pro Lys Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp 
        35                  40                  45              


Gln Ile Ala Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile 
    50                  55                  60                  


Ser Val His Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln 
65                  70                  75                  80  


Leu Glu Arg Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn 
                85                  90                  95      


Gln Gly Gly Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn 
            100                 105                 110         


Asn Gln Gly Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser 
        115                 120                 125             


Ile Asn Pro Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser 
    130                 135                 140                 


Trp Gly Met Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro 
145                 150                 155                 160 


Ser Gly Asn Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln 
                165                 170                 175     


Ala Phe Gly Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala 
            180                 185                 190         


Ala Ile Gly Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe 
        195                 200                 205             


Asn Gly Gly Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly 
    210                 215                 220                 


Met 
225 


<210>  98
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98

Met Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
1               5                   10                  15      


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
            20                  25                  30          


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
        35                  40                  45              


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
    50                  55                  60                  


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
                85                  90                  95      


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
            100                 105                 110         


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
        115                 120                 125             


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
    130                 135                 140         


<210>  99
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  99

Gly Glu Phe Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val 
1               5                   10                  15      


Ile Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp 
            20                  25                  30          


Ser Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg 
        35                  40                  45              


Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg 
    50                  55                  60                  


Lys Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu 
                85                  90                  95      


Gln Pro Met Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val 
            100                 105                 110         


Gln Leu Asp Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly 
        115                 120                 125             


Val Met Leu Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala Lys 
    130                 135                 140                 


Glu Leu Pro Asp Ala Asn Leu Arg Pro Glu Asp Leu Trp Ala Asn His 
145                 150                 155                 160 


Gly 
    


<210>  100
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  100

Met Leu Asp Met Gly Gln Asp Arg Pro Ile Asp Gly Ser Gly Ala Pro 
1               5                   10                  15      


Gly Ala Asp Asp Thr Arg Val Glu Val Gln Pro Pro Ala Gln Trp Val 
            20                  25                  30          


Leu Asp Leu Ile Glu Ala Ser Pro Ile Ala Ser Val Val Ser Asp Pro 
        35                  40                  45              


Arg Leu Ala Asp Asn Pro Leu Ile Ala Ile Asn Gln Ala Phe Thr Asp 
    50                  55                  60                  


Leu Thr Gly Tyr Ser Glu Glu Glu Cys Val Gly Arg Asn Cys Arg Phe 
65                  70                  75                  80  


Leu Ala Gly Ser Gly Thr Glu Pro Trp Leu Thr Asp Lys Ile Arg Gln 
                85                  90                  95      


Gly Val Arg Glu His Lys Pro Val Leu Val Glu Ile Leu Asn Tyr Lys 
            100                 105                 110         


Lys Asp Gly Thr Pro Phe Arg Asn Ala Val Leu Val Ala Pro Ile Tyr 
        115                 120                 125             


Asp Asp Asp Asp Glu Leu Leu Tyr Phe Leu Gly Ser Gln Val Glu Val 
    130                 135                 140                 


Asp Asp Asp Gln Pro Asn Met Gly Met Ala Arg Arg Glu Arg Ala Ala 
145                 150                 155                 160 


Glu Met Leu Lys Thr Leu Ser Pro Arg Gln Leu Glu Val Thr Thr Leu 
                165                 170                 175     


Val Ala Ser Gly Leu Arg Asn Lys Glu Val Ala Ala Arg Leu Gly Leu 
            180                 185                 190         


Ser Glu Lys Thr Val Lys Met His Arg Gly Leu Val Met Glu Lys Leu 
        195                 200                 205             


Asn Leu Lys Thr Ser Ala Asp Leu Val Arg Ile Ala Val Glu Ala Gly 
    210                 215                 220                 


Ile 
225 


<210>  101
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  101

Met Ala Ser Phe Gln Ser Phe Gly Ile Pro Gly Gln Leu Glu Val Ile 
1               5                   10                  15      


Lys Lys Ala Leu Asp His Val Arg Val Gly Val Val Ile Thr Asp Pro 
            20                  25                  30          


Ala Leu Glu Asp Asn Pro Ile Val Tyr Val Asn Gln Gly Phe Val Gln 
        35                  40                  45              


Met Thr Gly Tyr Glu Thr Glu Glu Ile Leu Gly Lys Asn Cys Arg Phe 
    50                  55                  60                  


Leu Gln Gly Lys His Thr Asp Pro Ala Glu Val Asp Asn Ile Arg Thr 
65                  70                  75                  80  


Ala Leu Gln Asn Lys Glu Pro Val Thr Val Gln Ile Gln Asn Tyr Lys 
                85                  90                  95      


Lys Asp Gly Thr Met Phe Trp Asn Glu Leu Asn Ile Asp Pro Met Glu 
            100                 105                 110         


Ile Glu Asp Lys Thr Tyr Phe Val Gly Ile Gln Asn Asp Ile Thr Lys 
        115                 120                 125             


Gln Lys Glu Tyr Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu Ile Thr 
    130                 135                 140                 


Ala Leu Ser Thr Pro Ile Val Pro Ile Arg Asn Gly Ile Ser Ala Leu 
145                 150                 155                 160 


Pro Leu Val Gly Asn Leu Thr Glu Glu Arg Phe Asn Ser Ile Val Cys 
                165                 170                 175     


Thr Leu Thr Asn Ile Leu Ser Thr Ser Lys Asp Asp Tyr Leu Ile Ile 
            180                 185                 190         


Asp Leu Ser Gly Leu Ala Gln Val Asn Glu Gln Thr Ala Asp Gln Ile 
        195                 200                 205             


Phe Lys Leu Ser His Leu Leu Lys Leu Thr Gly Thr Glu Leu Ile Ile 
    210                 215                 220                 


Thr Gly Ile Lys Pro Glu Leu Ala Met Lys Met Asn Lys Leu Asp Ala 
225                 230                 235                 240 


Asn Phe Ser Ser Leu Lys Thr Tyr Ser Asn Val Lys Asp Ala Val Lys 
                245                 250                 255     


Val Leu Pro Ile Met 
            260     


<210>  102
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  102

Met Asp Gln Lys Gln Phe Glu Lys Ile Arg Ala Val Phe Asp Arg Ser 
1               5                   10                  15      


Gly Val Ala Leu Thr Leu Val Asp Met Ser Leu Pro Glu Gln Pro Val 
            20                  25                  30          


Val Leu Ala Asn Pro Pro Phe Leu Arg Met Thr Gly Tyr Thr Glu Gly 
        35                  40                  45              


Gln Ile Leu Gly Phe Asn Cys Arg Phe Leu Gln Arg Gly Asp Glu Asn 
    50                  55                  60                  


Ala Gln Ala Arg Ala Asp Ile Arg Asp Ala Leu Lys Leu Gly Arg Glu 
65                  70                  75                  80  


Leu Gln Val Val Leu Arg Asn Tyr Arg Ala Asn Asp Glu Pro Phe Asp 
                85                  90                  95      


Asn Leu Leu Phe Leu His Pro Val Gly Gly Arg Pro Asp Ala Pro Asp 
            100                 105                 110         


Tyr Phe Leu Gly Ser Gln Phe Glu Leu Gly Arg Ser Gly Asn Ser Glu 
        115                 120                 125             


Glu Ala Ala Ala Ala Gly His Ala Gly Ala Leu Thr Gly Glu Leu Ala 
    130                 135                 140                 


Arg Ile Gly Thr Val Ala Ala Arg Leu Glu Met Asp Ser Arg Arg His 
145                 150                 155                 160 


Leu Ala Gln Ala Ala Ala Ala Leu Val Arg Ala Trp Glu Arg Arg Gly 
                165                 170                 175     


