                         SEQUENCE LISTING

<110>  Allysta Pharmaceuticals, Inc.
       Hsu, Henry
       Otvos, Laszlo
 
<120>  PEPTIDES FOR DRY EYE DISEASE

<130>  Ally001PCT

<140>  Unassigned
<141>  2018-03-06

<150>  US 62/469,170
<151>  2017-03-09

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  The C-terminal amino acid at position 14 is optionally amidated

<400>  1

Ser Val Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu Glu Arg 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-form Serine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is norleucine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  The C-terminal amino acid at position 14 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is ornithine

<400>  2

Xaa Val Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa Glu Xaa 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is N-methyl-glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is D-asparagine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  The C-terminal amino acid at position 14 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is 6-amino-hexanoic acid

<400>  3

Xaa Val Thr Xaa Gln Gly Ala Glu Leu Xaa Xaa Glu Glu Xaa 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  The C-terminal amino acid at position 13 is optionally amidated

<400>  4

Ser Val Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu Glu 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is N-methyl-glutamic acid

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  The C-terminal amino acid at position 13 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is glutamic acid methyl ester

<400>  5

Xaa Val Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa Xaa 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  The C-terminal amino acid at position 13 is optionally amidated

<400>  6

Val Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu Glu Arg 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is N-methyl-glutamic acid

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  The C-terminal amino acid at position 13 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is ornithine

<400>  7

Xaa Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa Glu Xaa 
1               5                   10              


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  The C-terminal amino acid at position 12 is optionally amidated

<400>  8

Val Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu Glu 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is N-methyl-glutamic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  The C-terminal amino acid at position 12 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is glutamic acid methyl ester

<400>  9

Xaa Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa Xaa 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is 1-amino-cyclohexyl carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is N-methyl-glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-asparagine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  The C-terminal amino acid at position 12 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-glutamine

<400>  10

Xaa Thr Xaa Gln Gly Ala Glu Leu Xaa Xaa Glu Xaa 
1               5                   10          


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  The C-terminal amino acid at position 11 is optionally amidated

<400>  11

Val Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is norleucine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  The C-terminal amino acid at position 11 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is N-methyl-glutamic acid

<400>  12

Xaa Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  The C-terminal amino acid at position 11 is optionally amidated

<400>  13

Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu Glu 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is N-methyl-glutamic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  The C-terminal amino acid at position 11 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is glutamic acid methyl ester

<400>  14

Xaa Glu Gln Gly Ala Glu Xaa Ser Asn Xaa Xaa 
1               5                   10      


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  The C-terminal amino acid at position 10 is optionally amidated

<400>  15

Thr Glu Gln Gly Ala Glu Leu Ser Asn Glu 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is  Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is norleucine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  The C-terminal amino acid at position 10 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is N-methyl-glutamic acid

<400>  16

Xaa Glu Gln Xaa Ala Glu Xaa Ser Asn Xaa 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is D-asparagine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  The C-terminal amino acid at position 10 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-glutamine

<400>  17

Xaa Glu Gln Gly Ala Glu Leu Xaa Xaa Xaa 
1               5                   10  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  18

Ser Val Thr Glu Gln Gly Ala Glu Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is norvaline

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is norleucine

<400>  19

Xaa Val Thr Glu Gln Xaa Ala Glu Xaa 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is beta-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is 6-amino-hexanoic acid

<400>  20

Xaa Val Thr Glu Gln Gly Xaa Glu Xaa 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  21

Val Thr Glu Gln Gly Ala Glu Leu Ser 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norvaline

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is D-serine

<400>  22

Xaa Thr Glu Gln Xaa Ala Glu Leu Xaa 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is 1-amino-cyclohexyl carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is beta-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is hydroxyproline

<400>  23

Xaa Thr Glu Gln Gly Xaa Glu Leu Xaa 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  24

Thr Glu Gln Gly Ala Glu Leu Ser Asn 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Allo-threonine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is norvaline

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is D-asparagine

<400>  25

Xaa Glu Gln Xaa Ala Glu Leu Ser Xaa 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is beta-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is D-glutamine

<400>  26

Xaa Glu Gln Gly Xaa Glu Leu Ser Xaa 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  27

Glu Gln Gly Ala Glu Leu Ser Asn Glu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is N-methyl-glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is norleucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is N-methyl-glutamic acid

<400>  28

Xaa Gln Gly Ala Glu Xaa Ser Asn Xaa 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is isoglutamine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is beta-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is glutamic acid methyl ester

<400>  29

Xaa Gln Gly Xaa Glu Leu Ser Asn Xaa 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  30

Gln Gly Ala Glu Leu Ser Asn Glu Glu 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-asparagine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is N-methyl-glutamic acid

<400>  31

Xaa Gly Ala Glu Xaa Ser Asn Glu Xaa 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is isoglutamine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is beta-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is glutamic acid methyl ester

<400>  32

Xaa Gly Xaa Glu Leu Ser Asn Glu Xaa 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<400>  33

Gly Ala Glu Leu Ser Asn Glu Glu Arg 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is norleucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is ornithine

<400>  34

Xaa Ala Glu Xaa Ser Asn Glu Glu Xaa 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is D-serine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  The C-terminal amino acid at position 9 is optionally amidated

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is N-methyl arginine

<400>  35

Xaa Ala Glu Leu Xaa Asn Glu Glu Xaa 
1               5                   


