                         SEQUENCE LISTING

<110>  VANDERBILT UNIVERSITY
 
<120>  HUMAN MONOCLONAL ANTIBODIES TO STAPHYLOCOCCUS AUREUS LukAB TOXIN

<130>  VBLT.P0268WO

<140>  Unknown
<141>  2018-03-06

<150>  US 62/467,619
<151>  2017-03-06

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  373
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
caggtgcagc tggtggagtc tgggggaggc ttggtcaggc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaatattaca tgagttggat ccgccaggct      120

ccagggaagg ggctggagtg gctttcatat attagcagta gtggtactac cataggccac      180

gcagactctc tgaagggccg attcaccatc tccagggaca acgccaggaa ctcactgttc      240

ctgcaaatga atagcctgag agccgaggac acggccgtct attactgtgc gagagatgga      300

gtggggggtc ccagggcgag atatgatgct tttgatatct ggggccaagg gaccctggtc      360

accgtctcct cag                                                         373


<210>  2
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggacctactc caacatcggg gcaggttatg atgtacactg gtaccaacag      120

cttccaggaa gagcccccaa actcctcatt tatggtaatc ggaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctgga acctcagcct ccctggccat cactgggctc      240

caggccgagg atgaggctga ttattactgc cagtcccatg acagcagtct gagtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210>  3
<211>  364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctaagactc       60

tcctgtgcag cctctggatt ctccttcagt acctatgaca tgaactgggt ccgccaggct      120

ccaggcaagg gactggagtg gctgtcaatt atatcatatg atgaaacaaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt      240

ctgcaaatga acagcctgaa acctgaggac tcggctgtct atcactgtgt caaagtaggg      300

tggactctag taggtgatgg tgttgatatg tggggccaag ggaccctggt caccgtctcc      360

tcag                                                                   364


<210>  4
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
cagcctgtgc tgactcagtc tccttcctcc ctgtctgcgt ctgttggaga cagagtcacc       60

atcagttgcc gggcgagtca gggcattagc cattatttag cctggtatca gcagcaacca      120

gggaaagttc ctaaactcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgtcg caacttatta ctgtcaaaag tataacggtg ccccattcac tttcggccct      300

gggaccaaag tggatatcaa gc                                               322


<210>  5
<211>  376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
caggtgcagc tggtgcagtc tgggggagcc gtcgtacagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct      120

ccggggaagg gtctggagtg ggtctctctt attactttgg atggtggccg cacatactat      180

gcagactctg tgaagggtcg attcaccatc tccagagaca acagcaagaa ctccctgtat      240

ctgcaaatga accgtctgag agctgacgac accggcttct attactgtgc aagagatata      300

aagatagggg aagcagttat gattactgtt ccgggccaac actggggcca gggcaccctg      360

gtcaccgtct cctcag                                                      376


<210>  6
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
cagtctgtgg tgactcagga ccctggtgtg tctgtggcct tgggacagac agtcttcatc       60

acatgccaag gagacaccct cagaagcaat tatgcaaact ggttccagca gaagccagga      120

caggcccctg tccttgtcat gtatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatgt ggtgttcggc      300

ggagggacca gggtgaccgt ccta                                             324


<210>  7
<211>  355
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
caggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactg       60

tcctgtgcag cctctggctt cagcgtcagt agcaactaca tgagttgggt ccgccaggct      120

ccaggaaagg ggctggagtg ggtctcagtt atttatagag atggaaccac atattacaca      180

gactccgtga agggccgatt aaccatctcc agagacattt ccaagaacat ggtgtacctt      240

caaatgaaca gcctaagagc cgaggacacg gccgtgtatt actgtgcgag agaggactcc      300

gtggacggct actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  8
<211>  302
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
tccatcctcc ctgtctgcat ctgtaggaga cagagtcgcc atcacttgcc gggcaagtca       60

gagcattagc aggtatttac attggtatca gcaaaaacca ggaaaagccc ctaagctcct      120

gatctatgct gcatccagtt tgcaaagtgg gatcccgtca aggttcagtg gcagtggagc      180

tgggacaaat ttcactctca ccatcagcag tctccaacct gaagattttg caacttacta      240

ctgtcaggag agttccaaca cccctccaac ttttggccag gggaccaagc tggagatcaa      300

ac                                                                     302


<210>  9
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Thr Thr Ile Gly His Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Val Gly Gly Pro Arg Ala Arg Tyr Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  10
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Thr Tyr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser His Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  11
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Tyr 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Ile Ile Ser Tyr Asp Glu Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      


Val Lys Val Gly Trp Thr Leu Val Gly Asp Gly Val Asp Met Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Gln Pro Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser His Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Gly Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  13
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Gly Ala Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Thr Leu Asp Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Asp Asp Thr Gly Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Lys Ile Gly Glu Ala Val Met Ile Thr Val Pro Gly 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gln Ser Val Val Thr Gln Asp Pro Gly Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Phe Ile Thr Cys Gln Gly Asp Thr Leu Arg Ser Asn Tyr Ala 
            20                  25                  30          


Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Arg Val Thr Val Leu 
            100                 105             


<210>  15
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Arg Asp Gly Thr Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Leu Thr Ile Ser Arg Asp Ile Ser Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Asp Ser Val Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Ala Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu His Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ala Gly Thr Asn Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Glu Ser Ser Asn Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
                85                  90                  95      


Leu Glu Ile Lys 
            100 


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  17

Gly Phe Thr Phe Ser Glu Tyr Tyr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  18

Ile Ser Ser Ser Gly Thr Thr Ile 
1               5               


<210>  19
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  19

Cys Ala Arg Asp Gly Val Gly Gly Pro Arg Ala Arg Tyr Asp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  20

Gly Phe Ser Phe Ser Thr Tyr Asp 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  21

Ile Ser Tyr Asp Glu Thr Asn Lys 
1               5               


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Cys Val Lys Val Gly Trp Thr Leu Val Gly Asp Gly Val Asp Met Trp 
1               5                   10                  15      


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  23

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

Ile Thr Leu Asp Gly Gly Arg Thr 
1               5               


<210>  25
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

Cys Ala Arg Asp Ile Lys Ile Gly Glu Ala Val Met Ile Thr Val Pro 
1               5                   10                  15      


Gly Gln His Trp 
            20  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Gly Phe Ser Val Ser Ser Asn Tyr 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  27

Ile Tyr Arg Asp Gly Thr Thr 
1               5           


<210>  28
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  28

Cys Ala Arg Glu Asp Ser Val Asp Gly Tyr Phe Asp Tyr Trp 
1               5                   10                  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  29

Tyr Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  30
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  30

Gly Asn Arg 
1           


<210>  31
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  31

Cys Gln Ser His Asp Ser Ser Leu Ser Gly Ser Val Phe 
1               5                   10              


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  32

Gln Gly Ile Ser His Tyr 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  33

Ala Ala Ser 
1           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  34

Cys Gln Lys Tyr Asn Gly Ala Pro Phe Thr Phe 
1               5                   10      


<210>  35
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  35

Thr Leu Arg Ser Asn Tyr 
1               5       


<210>  36
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  36

Gly Lys Asn 
1           


<210>  37
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  37

Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
1               5                   10              


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  38

Gln Ser Ile Ser Arg Tyr 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  39

Ala Ala Ser 
1           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  40

Cys Gln Glu Ser Ser Asn Thr Pro Pro Thr Phe 
1               5                   10      


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic phosphorothioate-modified oligodeoxynucleotide


<220>
<221>  modified_base
<222>  (1)..(20)
<223>  phosphorothioate base

<400>  41
tcgtcgtttt tcggtcgttt t                                                 21


