                         SEQUENCE LISTING

<110>  Deutsches Institut fuer Ernaehrungsforschung 
       Potsdam-Rehbruecke
       Sidra Medical and Research Center, Human Genetics 
       Department, Translational Medicine Division
       Saraiva, Lus Miguel Rodrigues
 
<120>  METHODS OF USING DPP-4 INHIBITORS IN TREATING BONE FRACTURES

<130>  504-17PCT

<150>  US62/469,453
<151>  2017-03-09

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  2
<211>  3913
<212>  DNA
<213>  Homo sapiens

<400>  2
ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg       60

tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag      120

gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg      180

ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc      240

gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc      300

tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc      360

cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat      420

gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg      480

caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc      540

acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt      600

gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat      660

gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat      720

agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa      780

aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt      840

acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt      900

attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac      960

atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag     1020

tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat     1080

gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata     1140

atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct     1200

ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc     1260

ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg     1320

gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca     1380

gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg     1440

ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg     1500

cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc     1560

agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg     1620

gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag     1680

atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac     1740

tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat     1800

tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa     1860

atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg     1920

tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc     1980

ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc     2040

ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa     2100

ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat     2160

tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa     2220

aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt     2280

atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca     2340

atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt     2400

tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg     2460

tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg     2520

gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc     2580

ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa     2640

aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt     2700

cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg     2760

tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc     2820

cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc     2880

catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga     2940

tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca     3000

aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac     3060

agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg     3120

aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt     3180

aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat     3240

gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc     3300

agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc     3360

cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa     3420

cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa     3480

aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat     3540

ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt     3600

aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat     3660

cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc     3720

ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact     3780

tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca     3840

ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa     3900

aaaaaaaaaa aaa                                                        3913


<210>  3
<211>  760
<212>  PRT
<213>  Mus musculus

<400>  3

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Val Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Ile Val Leu Leu Ser Lys Asp Glu 
            20                  25                  30          


Ala Ala Ala Asp Ser Arg Arg Thr Tyr Ser Leu Ala Asp Tyr Leu Lys 
        35                  40                  45              


Ser Thr Phe Arg Val Lys Ser Tyr Ser Leu Trp Trp Val Ser Asp Phe 
    50                  55                  60                  


Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Leu Leu Asn Ala Glu 
65                  70                  75                  80  


His Gly Asn Ser Ser Ile Phe Leu Glu Asn Ser Thr Phe Glu Ser Phe 
                85                  90                  95      


Gly Tyr His Ser Val Ser Pro Asp Arg Leu Phe Val Leu Leu Glu Tyr 
            100                 105                 110         


Asn Tyr Val Lys Gln Trp Arg His Ser Tyr Thr Ala Ser Tyr Asn Ile 
        115                 120                 125             


Tyr Asp Val Asn Lys Arg Gln Leu Ile Thr Glu Glu Lys Ile Pro Asn 
    130                 135                 140                 


Asn Thr Gln Trp Ile Thr Trp Ser Pro Glu Gly His Lys Leu Ala Tyr 
145                 150                 155                 160 


Val Trp Lys Asn Asp Ile Tyr Val Lys Val Glu Pro His Leu Pro Ser 
                165                 170                 175     


His Arg Ile Thr Ser Thr Gly Glu Glu Asn Val Ile Tyr Asn Gly Ile 
            180                 185                 190         


Thr Asp Trp Val Tyr Glu Glu Glu Val Phe Gly Ala Tyr Ser Ala Leu 
        195                 200                 205             


Trp Trp Ser Pro Asn Asn Thr Phe Leu Ala Tyr Ala Gln Phe Asn Asp 
    210                 215                 220                 


Thr Gly Val Pro Leu Ile Glu Tyr Ser Phe Tyr Ser Asp Glu Ser Leu 
225                 230                 235                 240 


Gln Tyr Pro Lys Thr Val Trp Ile Pro Tyr Pro Lys Ala Gly Ala Val 
                245                 250                 255     


Asn Pro Thr Val Lys Phe Phe Ile Val Asn Ile Asp Ser Leu Ser Ser 
            260                 265                 270         


Ser Ser Ser Ala Ala Pro Ile Gln Ile Pro Ala Pro Ala Ser Val Ala 
        275                 280                 285             


Arg Gly Asp His Tyr Leu Cys Asp Val Val Trp Ala Thr Glu Glu Arg 
    290                 295                 300                 


Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln Asn Tyr Ser Val Met Ala 
305                 310                 315                 320 


Ile Cys Asp Tyr Asp Lys Ile Asn Leu Thr Trp Asn Cys Pro Ser Glu 
                325                 330                 335     


Gln Gln His Val Glu Met Ser Thr Thr Gly Trp Val Gly Arg Phe Arg 
            340                 345                 350         


Pro Ala Glu Pro His Phe Thr Ser Asp Gly Ser Ser Phe Tyr Lys Ile 
        355                 360                 365             


Ile Ser Asp Lys Asp Gly Tyr Lys His Ile Cys His Phe Pro Lys Asp 
    370                 375                 380                 


Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly Ala Trp Glu Val Ile Ser 
385                 390                 395                 400 


Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr Tyr Ile Ser Asn Gln Tyr 
                405                 410                 415     


Lys Glu Met Pro Gly Gly Arg Asn Leu Tyr Lys Ile Gln Leu Thr Asp 
            420                 425                 430         


His Thr Asn Val Lys Cys Leu Ser Cys Asp Leu Asn Pro Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Ala Val Ser Phe Ser Lys Glu Ala Lys Tyr Tyr Gln Leu 
    450                 455                 460                 


Gly Cys Trp Gly Pro Gly Leu Pro Leu Tyr Thr Leu His Arg Ser Thr 
465                 470                 475                 480 


Asp His Lys Glu Leu Arg Val Leu Glu Asp Asn Ser Ala Leu Asp Arg 
                485                 490                 495     


Met Leu Gln Asp Val Gln Met Pro Ser Lys Lys Leu Asp Phe Ile Val 
            500                 505                 510         


Leu Asn Glu Thr Arg Phe Trp Tyr Gln Met Ile Leu Pro Pro His Phe 
        515                 520                 525             


Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu Asp Val Tyr Ala Gly Pro 
    530                 535                 540                 


Cys Ser Gln Lys Ala Asp Ala Ser Phe Arg Leu Asn Trp Ala Thr Tyr 
545                 550                 555                 560 


Leu Ala Ser Thr Glu Asn Ile Ile Val Ala Ser Phe Asp Gly Arg Gly 
                565                 570                 575     


Ser Gly Tyr Gln Gly Asp Lys Ile Met His Ala Ile Asn Arg Arg Leu 
            580                 585                 590         


Gly Thr Leu Glu Val Glu Asp Gln Ile Glu Ala Ala Arg Gln Phe Val 
        595                 600                 605             


Lys Met Gly Phe Val Asp Ser Lys Arg Val Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Thr Ser Met Val Leu Gly Ser Gly Ser Gly Val 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Arg Trp Glu Tyr Tyr 
                645                 650                 655     


Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly Leu Pro Ile Pro Glu Asp 
            660                 665                 670         


Asn Leu Asp His Tyr Arg Asn Ser Thr Val Met Ser Arg Ala Glu His 
        675                 680                 685             


Phe Lys Gln Val Glu Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Gln Ser Ala Gln Ile Ser Lys Ala Leu Val Asp Ala 
705                 710                 715                 720 


Gly Val Asp Phe Gln Ala Met Trp Tyr Thr Asp Glu Asp His Gly Ile 
                725                 730                 735     


Ala Ser Ser Thr Ala His Gln His Ile Tyr Ser His Met Ser His Phe 
            740                 745                 750         


Leu Gln Gln Cys Phe Ser Leu His 
        755                 760 


<210>  4
<211>  5268
<212>  DNA
<213>  Mus musculus

<400>  4
gactgacaga cctctcaggg aaggggacaa gagaactggc agctagtttc tgcagtgagc       60

cgtgaatctg ccaaactcca tgcctgcttg aacctcagct gcctcgatta tccacgcaag      120

ggagcaacag ttaaacctca atgtgcaatg tctcttttag caaagggggt tcgctgttcc      180

ccttatccct cactcatggg ggccctgcgt gctacttcct ggctcgccta gtggtcctac      240

cgcgctgggt cggctgcccc gcgctcacac tgtgcaccga agcccgcctt gcgctaacta      300

atgtttaact caggccgaaa cttggcggcg agctcagggt gactgcgtgc agagcagccg      360

cgcaggacgt ccgtctctgc gcgcagtgac ttctgcctgc gctcaagctt cagagttcag      420

tttcaaggag ccgcccgacc atgaagacac cgtggaaggt tcttctggga ctgcttggtg      480

tcgctgcgct tgtcaccatc atcaccgtgc caatagttct gctgagcaaa gatgaagcgg      540

cagctgacag ccgcagaacg tattcactag ctgactattt aaagagtacc tttcgggtca      600

agtcctactc tttgtggtgg gtttcagact ttgaatacct ctacaaacaa gagaacaata      660

tcttgctgct caatgctgaa catggaaaca gctccatttt cttggagaac agtacctttg      720

aaagctttgg atatcattca gtgtcacctg accgactgtt tgttctcttg gaatacaact      780

acgtgaagca atggagacat tcctacacag cttcatacaa catttatgat gtgaataaaa      840

gacagctgat cacagaagag aagattccaa ataatacaca gtggatcaca tggtcaccag      900

aaggtcataa gttggcatat gtctggaaga atgatattta cgttaaagtt gaaccacact      960

tacctagtca taggatcaca tcgacaggag aagaaaatgt aatatataat ggaataactg     1020

actgggttta tgaagaggaa gtcttcggtg cctactctgc actgtggtgg tctccaaaca     1080

acacgtttct agcttatgcc cagtttaacg acacaggagt gccgctcatt gaatactcct     1140

tctattctga tgagtcactg cagtacccca agacagtgtg gattccatac ccaaaggcag     1200

gagctgtgaa tccaactgta aagttcttta ttgtaaatat agactctctc agctcatcct     1260

ctagtgcggc tcccatccaa atccctgctc ctgcatctgt ggcaagaggg gatcactatt     1320

tatgtgatgt ggtgtgggct acagaagaaa gaatttcact acagtggctc aggaggattc     1380

agaactattc cgtgatggct atctgtgact atgataagat caacctaacg tggaactgtc     1440

catccgagca gcagcatgtt gaaatgagta ccacaggctg ggtcggaaga tttaggcccg     1500

cagaacctca cttcacctct gatggaagca gcttctataa gatcatcagc gacaaagatg     1560

gctacaaaca catctgccac ttcccgaaag ataagaaaga ctgtacattt attacaaaag     1620

gagcctggga agtcattagt atcgaagctc tgaccagcga ttatctatac tacattagta     1680

accaatataa agaaatgcca ggaggaagaa atctctataa aattcaactt actgaccaca     1740

caaatgtgaa gtgccttagt tgtgacctga atccagaaag atgtcagtat tatgcggtat     1800

catttagtaa agaggcaaag tactatcagc tgggatgttg gggccccggt ctgcccctct     1860

acactctaca tcgtagcacg gatcataaag agctgcgagt cctggaagac aattctgctt     1920

tggatagaat gctgcaggat gtccagatgc cttcaaaaaa attggacttc attgttttga     1980

atgaaacaag attttggtat caaatgatct tgccccctca ttttgataaa tccaagaaat     2040

atcctctact attagatgta tatgcaggtc cctgtagtca aaaagcagat gcttccttca     2100

gactgaactg ggccacttac cttgcaagta cagaaaacat catagtagct agctttgacg     2160

gcagaggaag tggttaccaa ggagataaga tcatgcatgc aatcaacaga agattgggaa     2220

cactggaagt tgaagatcaa attgaagcag ccaggcaatt tgtaaaaatg ggatttgtgg     2280

atagcaagcg agttgcaatt tggggctggt catatggagg gtatgtaacc tcaatggtcc     2340

tgggatcggg aagtggcgtg ttcaagtgcg gaatagctgt ggcacctgtg tcacggtggg     2400

agtactatga ctcagtgtac acagagcgtt acatgggtct cccaattcca gaagacaacc     2460

ttgaccatta caggaactca acagtcatga gcagagctga acattttaaa caagttgagt     2520

acctccttat tcatggaacg gcagatgata atgttcactt tcagcagtca gctcagatct     2580

ccaaagccct ggtggatgct ggtgtggatt tccaagcaat gtggtacacg gatgaagacc     2640

acgggatcgc tagcagcaca gctcaccagc acatctattc ccacatgagc catttcctcc     2700

agcagtgctt ctccttacac tagcacagca tagctctcca tagcttattt aagaccacat     2760

ttgttctcat tatctcaaaa gtgcactgtt aagatgaaga tcttaataat gttgcattga     2820

gacatttcag gctgctttct ccagttttac acctgcaatc ctaactaagg atgcctgtcc     2880

ccagaacaga ttactacctt agagcaattt ggattttccc ctctgttttg tttatcattt     2940

aaaatcattt ccacatcagc tgctgaaaca acaaatataa attatttttg caagagctat     3000

gcatagattt cctgagcaga atttcaattt tttttttcct tactagactg gtccaaatct     3060

cgtttccctt atttaagtgg gtgacaagat gtgggtaatg atgtcattag ggcagcaaca     3120

agagaagagg gagcagggag tatggctaga aacccaggtc caagcataca aaccaaccag     3180

gctactgtca gctcgcctcg agaagagctg ttcactgcca gactggcaca gttttctgag     3240

aaagactatt caaacagtct caggaaatca tatatgcaaa gcactgactt ctaagtaaaa     3300

ccacagcagt tgaatagact ccaaagaaat gcaagggacg ctgccagcaa tgtaagggcc     3360

ccaggtgcca gttatggcta taggtgctac aaaaacacag caagggtgat gggaaagcat     3420

tgtaaatgtg cttttgaaaa ttaccgatgt ctcctagtga aaagaggcag cttggaacat     3480

atcgacttgc cctgttaaaa gttgaaaata tttgtgtcac aaattctaac atgaaggaat     3540

acttgcatta gtttttccta cttcatttct ttgagcattt taattaaaat attttaactt     3600

cattagcttt ttaatggaaa attaaatgag aatgttttgt gttattattt ctattctaca     3660

cactggaact ttgcctggtc atttagtaaa tatgcttcca tttttcagag gtaatgggtt     3720

atgtcttgaa tcaaacttac accgcattga catatggaca catttgttca aaggttcttg     3780

tttaacttgt tagacatcca agactgtctt gtaaacatgg aaagagttca gctttttttt     3840

aaaaaaaatt agatacataa aactgtttaa acttaaatga ttcatagggg tttctctaat     3900

accccctgaa atgtctattt tcacacttat cacatagctt tggagaaatc aattaacaat     3960

aatttggtca tttaaatact atggaattca taatataatt taatctaggg gagcatgtga     4020

ggctcacagc atgggacaga acactatcag cagagtcgtt ttggttgact tgtctttcca     4080

gggttttctg tattgttttg tctctggtct cttcttgtgg gggggtgata taatagaaaa     4140

catacattct gatattgaac ttgacttagc aatgtttgga taacttagaa aatactacgt     4200

tttgtttcaa ttatttataa cacaactgca tttttaaaat ggacttcaca catttaaatg     4260

cagtttcaga ccagagtgct agataaaatt attctggaca ggtgagccac agcatgaatt     4320

gcaaacgtgg cagaaatgga aactacctat caaataaggg tgggattaga tattcatgag     4380

cttgatgcca cttcccaggc ccccccacgg attcactcca ccttaagtaa gtctcaagtc     4440

ctattcttcc attgcaagca ctgctggtaa gtaagcctgt aggtttctgg ctataatcct     4500

attttagaat acagcacttt caccatgtgc agcagtatcc acctgcaaag ttctagatca     4560

agggacagag gtgacatgtt cctgtcagtg tgaaaacata aacagaaatt acccgttgtg     4620

aattcatcaa tctaaacccc attatataat aatctagatt ttattaatat atcttatatg     4680

atgtatcaca taatatttat ataatagcca aaccatgaat tttgtgttcc ttttgtttct     4740

aaatatgttg tttctggagc ctgaattaat caaatatcac agcacacatt tttcaggcaa     4800

tgatggtttc aaatggtgat aatgtgaata aattcagttt ttatttgact ctcatagcac     4860

aagttttact gttccgtaag agttgtgaat tagattaaga acctgatgcg gaagttctaa     4920

gtgaactcaa gagtaagttt gaaaagcaca agagctagta acgtcactaa gggacataga     4980

cctgtctctg agggacatat gcattctctg gaagcacatg gatcgagctt ccttctcaga     5040

gcacaccagc atcaggggcg catgcgctaa gggaaggccg ccctgacgct tcactatcca     5100

ggatcacttc agtctgtgcc attccgggca ctgtggttct cggagtatta gcagttccac     5160

ctcttggcgc ttattgctct tgctctaagt tggagtgaga atgccggttt ataaaattac     5220

tagatttgta caatatttaa gattcaataa attctaagtg aaaaaaca                  5268


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  5
agtcggtgga caagaacagc                                                   20


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  6
tcactggtca actccagca                                                    19


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  7
atcacaactg gcctggttac g                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  8
tactacccgg tgtccatttc t                                                 21


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  9
cggtatcatt tagtaaagag gcaaa                                             25


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  10
gtagagtgta gaggggcaga cc                                                22


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  11
gatgcctttg tgggaacct                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  12
ctgtcgtctg cggtgattt                                                    19


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  13
cctcatcaag accattgtca cc                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  14
tctccaggtc attggctatc tg                                                22


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  15
caaatgctgg accaaacaca a                                                 21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  16
aagaccacat gcttgccat                                                    19


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  17
ctccaagaat accaaagtgc ga                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  18
gcctgatgct ttatccccac a                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  19
tcctcggttc tctccatctg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  20
ggactggagc catagtgagc                                                   20


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  21
ttcaacgatc tgagatttgt ggg                                               23


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  22
ggatgaggaa tgcgcccta                                                    19


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  23
caaatcagct ttgcctcact c                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-derived

<400>  24
taagccggct gagatcttgt                                                   20


