                         SEQUENCE LISTING

<110>  Firmenich SA
       Pfister, Patrick
       Rogers, Matthew E
       Kao, Huey-Ling
       Abibi, Claude Ayome
 
<120>  Method of identifying malodor modulating compounds

<130>  10020/WO

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  957
<212>  DNA
<213>  Mus musculus

<400>  1
atggcctcaa ggacttattc catggaagaa gtaaataatg tcactgaatt cattttcttg       60

ggtctttctc agaaccctga ggttgaaaaa gtgtgctttg tggtgttctc cttcttttac      120

atggtcattc tgctaggaaa cctcctcatc atgttgacag tttgcagtgg caatcttttc      180

aagtttccca tgtatttttt cctcaacttt ctgtcttttg tggacatttg ctactcctca      240

gtcacagcac ccaagatgat tattgacctg ttagtgaaga aaaagactat atcctatgtg      300

gggtgcatgt tacaactctt tgtggttcat ttctttggtt gcactgagat cttcattctt      360

actgtcatgg cctatgatag atatgtggcc atttgtaaac ctctccacta tatgactatg      420

atggaccggg aaagatgcaa taagatgttg ctcggaacat ggatcggtgg cttcttacat      480

tctattatcc aagtggctct tgtggtccag ctcccctttt gtggaccgaa tgagattgat      540

cactatttct gtgatgtaca tcctgtactg aaacttgcct gcactgacac ttacattgtt      600

ggtatttttg tgacagcaaa cagtggcacc attgcattgg gaagttttgt catcttgctg      660

atctcataca cagtcattct catgtctctg agaaagcagt catctgaagg cagacgcaaa      720

gctctctcca cttgtggatc ccacattgct gttgtcatca ttttttttgg cccctgtact      780

tttatgtata tgcggcctga cactaccttc tctgaggaca agatggtagc tatattttac      840

accattatca ctcccatgct gaatcctcta atttacactc taagaaatgc agaagtaaag      900

aatgcaatga gaaaactgtg ggctagaaag ttttcctggg aaactactgg gaaatag         957


<210>  2
<211>  318
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Ser Arg Thr Tyr Ser Met Glu Glu Val Asn Asn Val Thr Glu 
1               5                   10                  15      


Phe Ile Phe Leu Gly Leu Ser Gln Asn Pro Glu Val Glu Lys Val Cys 
            20                  25                  30          


Phe Val Val Phe Ser Phe Phe Tyr Met Val Ile Leu Leu Gly Asn Leu 
        35                  40                  45              


Leu Ile Met Leu Thr Val Cys Ser Gly Asn Leu Phe Lys Phe Pro Met 
    50                  55                  60                  


Tyr Phe Phe Leu Asn Phe Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser 
65                  70                  75                  80  


Val Thr Ala Pro Lys Met Ile Ile Asp Leu Leu Val Lys Lys Lys Thr 
                85                  90                  95      


Ile Ser Tyr Val Gly Cys Met Leu Gln Leu Phe Val Val His Phe Phe 
            100                 105                 110         


Gly Cys Thr Glu Ile Phe Ile Leu Thr Val Met Ala Tyr Asp Arg Tyr 
        115                 120                 125             


Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Met Met Asp Arg Glu 
    130                 135                 140                 


Arg Cys Asn Lys Met Leu Leu Gly Thr Trp Ile Gly Gly Phe Leu His 
145                 150                 155                 160 


Ser Ile Ile Gln Val Ala Leu Val Val Gln Leu Pro Phe Cys Gly Pro 
                165                 170                 175     


Asn Glu Ile Asp His Tyr Phe Cys Asp Val His Pro Val Leu Lys Leu 
            180                 185                 190         


Ala Cys Thr Asp Thr Tyr Ile Val Gly Ile Phe Val Thr Ala Asn Ser 
        195                 200                 205             


Gly Thr Ile Ala Leu Gly Ser Phe Val Ile Leu Leu Ile Ser Tyr Thr 
    210                 215                 220                 


Val Ile Leu Met Ser Leu Arg Lys Gln Ser Ser Glu Gly Arg Arg Lys 
225                 230                 235                 240 


Ala Leu Ser Thr Cys Gly Ser His Ile Ala Val Val Ile Ile Phe Phe 
                245                 250                 255     


Gly Pro Cys Thr Phe Met Tyr Met Arg Pro Asp Thr Thr Phe Ser Glu 
            260                 265                 270         


Asp Lys Met Val Ala Ile Phe Tyr Thr Ile Ile Thr Pro Met Leu Asn 
        275                 280                 285             


Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu Val Lys Asn Ala Met Arg 
    290                 295                 300                 


Lys Leu Trp Ala Arg Lys Phe Ser Trp Glu Thr Thr Gly Lys 
305                 310                 315             


<210>  3
<211>  969
<212>  DNA
<213>  Mus musculus

<400>  3
atggaaaaga tcacatcagc tgtggatgtc cacaatattc cattaaagaa catgactgaa       60

gccaccatgt ttattctctt aggattcaca gatgactttg aactccaagt cttcctgttt      120

ttactgtttc ttgctattta tctcttcact ctggtaggaa actttggact ggttgttttg      180

gtcattgggg attgtcggct acacaacccc atgtactatt tcctaagtgt tttgtctttc      240

ctggatgctt gctattctac agttgttaca cccaaaatgt tggtcaactt tctaagtgaa      300

aataagtcca tttcattcct tgcatgtgca acccaaatgc ttctctttgt ttcgttggga      360

accacagaat gctttctcct ggcagcaatg gcttatgacc gatatgtagc catctacaac      420

ccacttctgt atacagtggc catgtcaccc agagtatacc tgccactcat cattgcttcc      480

tatgctggtg gagttgtgca tggtgctatc cacacagtgg ccactttcag tctgtccttc      540

tgtggatcca atgaaattaa gcatgtcttc tgtgacatcc ctgcattgct tgctctttct      600

tgttctgata cccacacaaa tgagcttcta gtcttgtact tggtgggctt gattgagatt      660

gttaccatcc tgattgttct ggtctcctat ggattcatcc tctttgccat tctgaacatg      720

cattctgctg agggtaggag gaaagtgttc tctacatgtg gctctcacct cactggagtc      780

tctatttacc atggtacaat ccttttcact tatatgaggc ctagttccag ttatgcttca      840

aatcatgaca tggtagtgtc aatattttac accattgtga tacccatgtt gaatcctatc      900

atctatagtt tgaggaacaa agatgtaaaa gtagcattta ataaattgtg gagaaaatgt      960

gattcataa                                                              969


<210>  4
<211>  322
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Lys Ile Thr Ser Ala Val Asp Val His Asn Ile Pro Leu Lys 
1               5                   10                  15      


Asn Met Thr Glu Ala Thr Met Phe Ile Leu Leu Gly Phe Thr Asp Asp 
            20                  25                  30          


Phe Glu Leu Gln Val Phe Leu Phe Leu Leu Phe Leu Ala Ile Tyr Leu 
        35                  40                  45              


Phe Thr Leu Val Gly Asn Phe Gly Leu Val Val Leu Val Ile Gly Asp 
    50                  55                  60                  


Cys Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu Ser Phe 
65                  70                  75                  80  


Leu Asp Ala Cys Tyr Ser Thr Val Val Thr Pro Lys Met Leu Val Asn 
                85                  90                  95      


Phe Leu Ser Glu Asn Lys Ser Ile Ser Phe Leu Ala Cys Ala Thr Gln 
            100                 105                 110         


Met Leu Leu Phe Val Ser Leu Gly Thr Thr Glu Cys Phe Leu Leu Ala 
        115                 120                 125             


Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu Leu Tyr 
    130                 135                 140                 


Thr Val Ala Met Ser Pro Arg Val Tyr Leu Pro Leu Ile Ile Ala Ser 
145                 150                 155                 160 


Tyr Ala Gly Gly Val Val His Gly Ala Ile His Thr Val Ala Thr Phe 
                165                 170                 175     


Ser Leu Ser Phe Cys Gly Ser Asn Glu Ile Lys His Val Phe Cys Asp 
            180                 185                 190         


Ile Pro Ala Leu Leu Ala Leu Ser Cys Ser Asp Thr His Thr Asn Glu 
        195                 200                 205             


Leu Leu Val Leu Tyr Leu Val Gly Leu Ile Glu Ile Val Thr Ile Leu 
    210                 215                 220                 


Ile Val Leu Val Ser Tyr Gly Phe Ile Leu Phe Ala Ile Leu Asn Met 
225                 230                 235                 240 


His Ser Ala Glu Gly Arg Arg Lys Val Phe Ser Thr Cys Gly Ser His 
                245                 250                 255     


Leu Thr Gly Val Ser Ile Tyr His Gly Thr Ile Leu Phe Thr Tyr Met 
            260                 265                 270         


Arg Pro Ser Ser Ser Tyr Ala Ser Asn His Asp Met Val Val Ser Ile 
        275                 280                 285             


Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu 
    290                 295                 300                 


Arg Asn Lys Asp Val Lys Val Ala Phe Asn Lys Leu Trp Arg Lys Cys 
305                 310                 315                 320 


Asp Ser 
        


<210>  5
<211>  948
<212>  DNA
<213>  Mus musculus

<400>  5
atgagtgcct gtaatcatac aaatgaacct gagttcacgc ttgtgggact gacagactcc       60

aaggagattc agctggtcct ctctgttttg tttctcctga tatacatgct cactgtcttg      120

ggaaacatag gtatgatact gatcattcat ctagatgtcc agctccacac tccaatgtat      180

tttttcctca cccacttgtc attccttgac ctcagttact caactgtaat cacacctaaa      240

accttacaga atacgctgac ctccataaaa aatatttcct tcatgggatg cttcacccag      300

ttgtatttct ttgtcctctt ggcagcttct gaatgtttta tactttcgtc aatggcctat      360

gaccgctatg tagctatctg caaccctcta cactatccag ttattatgtc ccctaggcgc      420

tcatatactc tcatcactgt gtcctacatg attggagttt tggattcttc tgtcactgtc      480

ttttgcttaa gcacactgga tttctgcaac tccaaagtaa ttcatcactt cttttgtgac      540

acattcccaa ttttagctct gtcctgcagt gatacctata atgcagaagc cactatattc      600

gttttagctg gttccactct attgctgtcg ctcatcacga tatcctcatc ctatgtatct      660

attctctcta caattttgaa gataaattct tcttcaggaa agcacaaagc cttctctaca      720

tgtgcctcac atcttatagg agtcactgtt ttttatggta caatgatctt tacttattta      780

aaaccaagta cgtcctactc cctgggaaag gatcaagtag cctctgtttt ttatactata      840

gtgattccca tgctgaaccc acttatctat agtctcagga acaaagaagt gaaaagtgct      900

gttgttagag ttatgaagaa gagagagtgc atccagaaac tagaataa                   948


<210>  6
<211>  315
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ser Ala Cys Asn His Thr Asn Glu Pro Glu Phe Thr Leu Val Gly 
1               5                   10                  15      


Leu Thr Asp Ser Lys Glu Ile Gln Leu Val Leu Ser Val Leu Phe Leu 
            20                  25                  30          


Leu Ile Tyr Met Leu Thr Val Leu Gly Asn Ile Gly Met Ile Leu Ile 
        35                  40                  45              


Ile His Leu Asp Val Gln Leu His Thr Pro Met Tyr Phe Phe Leu Thr 
    50                  55                  60                  


His Leu Ser Phe Leu Asp Leu Ser Tyr Ser Thr Val Ile Thr Pro Lys 
65                  70                  75                  80  


Thr Leu Gln Asn Thr Leu Thr Ser Ile Lys Asn Ile Ser Phe Met Gly 
                85                  90                  95      


Cys Phe Thr Gln Leu Tyr Phe Phe Val Leu Leu Ala Ala Ser Glu Cys 
            100                 105                 110         


Phe Ile Leu Ser Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu His Tyr Pro Val Ile Met Ser Pro Arg Arg Ser Tyr Thr Leu 
    130                 135                 140                 


Ile Thr Val Ser Tyr Met Ile Gly Val Leu Asp Ser Ser Val Thr Val 
145                 150                 155                 160 


Phe Cys Leu Ser Thr Leu Asp Phe Cys Asn Ser Lys Val Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Thr Phe Pro Ile Leu Ala Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


Tyr Asn Ala Glu Ala Thr Ile Phe Val Leu Ala Gly Ser Thr Leu Leu 
        195                 200                 205             


Leu Ser Leu Ile Thr Ile Ser Ser Ser Tyr Val Ser Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Asn Ser Ser Ser Gly Lys His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Leu Ile Gly Val Thr Val Phe Tyr Gly Thr Met Ile 
                245                 250                 255     


Phe Thr Tyr Leu Lys Pro Ser Thr Ser Tyr Ser Leu Gly Lys Asp Gln 
            260                 265                 270         


Val Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Val Val Arg Val 
    290                 295                 300                 


Met Lys Lys Arg Glu Cys Ile Gln Lys Leu Glu 
305                 310                 315 


<210>  7
<211>  939
<212>  DNA
<213>  Mus musculus

<400>  7
atggagaaat ggaatcagag ctcaagtgat tttactctgt taggactgct tccacaaaac       60

caaacaggcc tgctactttt gatgctcatc atctttgtct tctctctggc tttgtgtggc      120

aactcaggaa tgatccacct cattcgtgtg gatccaaggc tccacacccc catgtacttt      180

ctcctcagtc agctctctct catggacctg atgtacattt ctaccactgt tcccaagatg      240

gcatttaact tcctttctgg ccagaaaagc atctcttttc tgggctgtgg agtgcaatcc      300

ttcttcttcc tgactatggc atgttctgag ggcttgctct tggcttccat ggcttatgat      360

cgttttgtgg ctatctgcca tccccttcac tatcccattc gcatgagcaa aataatgtgt      420

ctgaagatga tcataggatc ctggatattg ggctcaatca actctttagc acataccgtc      480

tatgcccttc atattcctta ctgccattct aggtccatta accatttctt ctgtgatgtt      540

ccagccatgt tgcccctggc ctgtatggac acttgggttt atgagtacat ggtgtttgtg      600

agcacaagcc tgtttctcct actgcctttc cttggtatca cagcttccta tggtcgggtc      660

ctttttgctg tcttccacat gcgctcaaaa gagggaaaga agaaggcctt caccacatgc      720

tcaactcact taactgtggt gacattttac tatgcacctt ttgtctatac ctatcttcga      780

cctaggagtc ttcgctcccc aacagaagat aagattctgg ctgttttcta cactatcctt      840

acccccatgc tcaaccccat catttatagt ctgaggaata aggaggtcct gggggccatg      900

acaagagtcc ttggtacttt tccttcaact aaaccgtaa                             939


<210>  8
<211>  312
<212>  PRT
<213>  Mus musculus

<400>  8

Met Glu Lys Trp Asn Gln Ser Ser Ser Asp Phe Thr Leu Leu Gly Leu 
1               5                   10                  15      


Leu Pro Gln Asn Gln Thr Gly Leu Leu Leu Leu Met Leu Ile Ile Phe 
            20                  25                  30          


Val Phe Ser Leu Ala Leu Cys Gly Asn Ser Gly Met Ile His Leu Ile 
        35                  40                  45              


Arg Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
65                  70                  75                  80  


Ala Phe Asn Phe Leu Ser Gly Gln Lys Ser Ile Ser Phe Leu Gly Cys 
                85                  90                  95      


Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 
            100                 105                 110         


Leu Leu Ala Ser Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu His Tyr Pro Ile Arg Met Ser Lys Ile Met Cys Leu Lys Met Ile 
    130                 135                 140                 


Ile Gly Ser Trp Ile Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 
145                 150                 155                 160 


Tyr Ala Leu His Ile Pro Tyr Cys His Ser Arg Ser Ile Asn His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Pro Leu Ala Cys Met Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Leu 
        195                 200                 205             


Pro Phe Leu Gly Ile Thr Ala Ser Tyr Gly Arg Val Leu Phe Ala Val 
    210                 215                 220                 


Phe His Met Arg Ser Lys Glu Gly Lys Lys Lys Ala Phe Thr Thr Cys 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Thr Arg Val Leu 
    290                 295                 300                 


Gly Thr Phe Pro Ser Thr Lys Pro 
305                 310         


<210>  9
<211>  942
<212>  DNA
<213>  Mus musculus

<400>  9
atggaatatg agaactacac ttttaacagc gacttcatcc tcttgggact gttctcttct       60

tcaaagacaa gcttaacttt tttctcattt atatttttca tttttattat ggctataaca      120

gaaaatgccc tcatgatcct cctaatccac agggattctc gactccatac cccaatgtat      180

ttcctgctta gtcatctctc cttcatggat atcttgcaca tttccaacat tgttcctaaa      240

atgattgctg acttcctctc aggcagcaga actatttcct ttgcaggctg tgccttccag      300

atatttctct ctcttacctt gctaggtggt gagtgccttc tcctggcagc catgtcctat      360

gatcgatatg tggccatctg ccacccactt cgctaccctg tgctgatgag ggataactcc      420

agtaggctcc tggctgcagg ctcctggctg gtggggatcc tcaactccat agtacacaca      480

gtttttgcac tccactttcc cttctgccac tcaagagcca ttgatcactt tttctgcgaa      540

gtccctgcca tgttgaaatt gtcatgtata gacacaacac actatgaacg aggcgtttat      600

gtgagtggca ttatttttct gctgatccca ttttccatga tctctatatc ttatgtgcaa      660

attctcctca ctgtattcca aatgcagtca tcaggggccc ggcaaaagtc cttttccacc      720

tgttccttcc acatggttgt tgtcataatg tactatgggc cattcatttt tacatatatg      780

agacctcgct cataccacac tccagggcag gataaatttt tggcaatatt ctacaccatc      840

ctgacaccca cactcaaccc cataatctac agctttcgta ataaagatgt ccttatggct      900

gtgaaaaaca tcgtccaaag taattttttg aataaaaaat ga                         942


<210>  10
<211>  313
<212>  PRT
<213>  Mus musculus

<400>  10

Met Glu Tyr Glu Asn Tyr Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 
1               5                   10                  15      


Leu Phe Ser Ser Ser Lys Thr Ser Leu Thr Phe Phe Ser Phe Ile Phe 
            20                  25                  30          


Phe Ile Phe Ile Met Ala Ile Thr Glu Asn Ala Leu Met Ile Leu Leu 
        35                  40                  45              


Ile His Arg Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 
    50                  55                  60                  


His Leu Ser Phe Met Asp Ile Leu His Ile Ser Asn Ile Val Pro Lys 
65                  70                  75                  80  


Met Ile Ala Asp Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly 
                85                  90                  95      


Cys Ala Phe Gln Ile Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Leu Met Arg Asp Asn Ser Ser Arg Leu Leu 
    130                 135                 140                 


Ala Ala Gly Ser Trp Leu Val Gly Ile Leu Asn Ser Ile Val His Thr 
145                 150                 155                 160 


Val Phe Ala Leu His Phe Pro Phe Cys His Ser Arg Ala Ile Asp His 
                165                 170                 175     


Phe Phe Cys Glu Val Pro Ala Met Leu Lys Leu Ser Cys Ile Asp Thr 
            180                 185                 190         


Thr His Tyr Glu Arg Gly Val Tyr Val Ser Gly Ile Ile Phe Leu Leu 
        195                 200                 205             


Ile Pro Phe Ser Met Ile Ser Ile Ser Tyr Val Gln Ile Leu Leu Thr 
    210                 215                 220                 


Val Phe Gln Met Gln Ser Ser Gly Ala Arg Gln Lys Ser Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Phe His Met Val Val Val Ile Met Tyr Tyr Gly Pro Phe Ile 
                245                 250                 255     


Phe Thr Tyr Met Arg Pro Arg Ser Tyr His Thr Pro Gly Gln Asp Lys 
            260                 265                 270         


Phe Leu Ala Ile Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Phe Arg Asn Lys Asp Val Leu Met Ala Val Lys Asn Ile 
    290                 295                 300                 


Val Gln Ser Asn Phe Leu Asn Lys Lys 
305                 310             


<210>  11
<211>  936
<212>  DNA
<213>  Mus musculus

<400>  11
atgaaagcct ttagcagccc cagcaactcc agcatcatca ctggcttcat cctcctgggc       60

ttcccctgcc ccaaggaggg gcaaatcctc ctctttgtgc tcttcttcat tatctacatc      120

cttaccctca tgggcaatgc ttccatcata tgtgctgtgt gctatgataa gaaacttcac      180

agccccatgt acctcctgct ggccaacttc tccttcctag aaatctggta tgtcacctcc      240

acagtcccca acatgttggc caacttcctc tctgacacga aggtcatctc tttctctgga      300

tgcttcctgc agttctattt cttcttctcc ttgggttcta cagaatgctt tttcctggca      360

gtcatggcat ttgatcgata ccttgccatc tgcagacctc tacattatcc ttctctcatg      420

actgggcgcc tctgcaacat ccttgtgatc agttgctggg tgcttggttt cctctggttc      480

cctgttccca tcatcatcat ctcccaaatg tccttctgtg gatccagaat tatagaccac      540

ttcctgtgtg acccaggccc tctgttggcc ctcacctgtg tgagaaattc tttaattgag      600

atgactagct ctactttaag ttccctgctt ttatttgttc catttttttt tatcatgggg      660

tcttatgctc tagtaatgag ggctgtgctc agggtccctt cagcagctgg acgaagaaag      720

gccttctcca cctgtgggtc acacttgact gtggtttctc ttttctatgg ctcagtgatg      780

gtcatgtatg tgagcccaac atctgaacat gcagctggag tgcaaaaact tgtgactctg      840

ttttattctg tggttactcc cctccttaat cctgtgatat acagtctgag gaacagagat      900

atgaaacatg caatgaaaaa gttactgaaa atgtaa                                936


<210>  12
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  12

Met Lys Ala Phe Ser Ser Pro Ser Asn Ser Ser Ile Ile Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Pro Cys Pro Lys Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Leu Phe Phe Ile Ile Tyr Ile Leu Thr Leu Met Gly Asn Ala Ser 
        35                  40                  45              


Ile Ile Cys Ala Val Cys Tyr Asp Lys Lys Leu His Ser Pro Met Tyr 
    50                  55                  60                  


Leu Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 
            100                 105                 110         


Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu His Tyr Pro Ser Leu Met Thr Gly Arg Leu 
    130                 135                 140                 


Cys Asn Ile Leu Val Ile Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 
145                 150                 155                 160 


Pro Val Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Thr 
            180                 185                 190         


Cys Val Arg Asn Ser Leu Ile Glu Met Thr Ser Ser Thr Leu Ser Ser 
        195                 200                 205             


Leu Leu Leu Phe Val Pro Phe Phe Phe Ile Met Gly Ser Tyr Ala Leu 
    210                 215                 220                 


Val Met Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg Arg Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr 
                245                 250                 255     


Gly Ser Val Met Val Met Tyr Val Ser Pro Thr Ser Glu His Ala Ala 
            260                 265                 270         


Gly Val Gln Lys Leu Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu 
        275                 280                 285             


Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys His Ala 
    290                 295                 300                 


Met Lys Lys Leu Leu Lys Met 
305                 310     


<210>  13
<211>  936
<212>  DNA
<213>  Mus musculus

<400>  13
atgaaaaccc tcagcagccc cagcaactcc agcaccatca ctggcttcat cctcttgggc       60

ttcccctgcc ccagggaggg gcaaatcctc ctctttgtga ccttcttcat tgtttacata      120

ctcattctta tgggcaatgc ttccatcatc tgtgctgtgt actgtgatca gagcctccac      180

acccccatgt acttcctgct ggccaacttc tccttcctgg agatctggta tgtcacctcc      240

acagtcccca acatgttggc caacttcctt tcagacacca aggtcatctc tttctctgga      300

tgcttcctgc agttctattt cttcttctcc tttggttcta cagaatgctt tttcctggca      360

gtcatggcat ttgatcgata ccttgccatc tgtaggccac tacattatcc ttctctcatg      420

actgggcacc tctgcaacat ccttgtgatc agttgctggg tgcttggttt cctctggttc      480

cctgtaccca tcatcatcat ctcccagatg tccttctgtg ggtccagaat tatagaccac      540

ttcctgtgtg acccaggccc tcttttggcc cttgcctgtt ccagagcccc attgatggag      600

gttttctgga caattataat gtctatgctc ctggttattc ctttcctctt catcatggga      660

acttacatat tggtcctaag agctgtgttt agacttcctt caagagatgg acaaaaaaag      720

gccttctcca cttgcgggtc tcatctcaca gtagtttcac tcttttattg ctcagtgatg      780

aaaatgtatt tgagcccaac atctgagcat gaagctggaa tgcagaagct tgtaactcta      840

ttttattctg tgggtactcc actacttaat cctgtgatat acagtctgag gaacaaagat      900

atgaaaaatg ccctgcagaa gattttaaga acataa                                936


<210>  14
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  14

Met Lys Thr Leu Ser Ser Pro Ser Asn Ser Ser Thr Ile Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Thr Phe Phe Ile Val Tyr Ile Leu Ile Leu Met Gly Asn Ala Ser 
        35                  40                  45              


Ile Ile Cys Ala Val Tyr Cys Asp Gln Ser Leu His Thr Pro Met Tyr 
    50                  55                  60                  


Phe Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Phe Gly 
            100                 105                 110         


Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu His Tyr Pro Ser Leu Met Thr Gly His Leu 
    130                 135                 140                 


Cys Asn Ile Leu Val Ile Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 
145                 150                 155                 160 


Pro Val Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Ala 
            180                 185                 190         


Cys Ser Arg Ala Pro Leu Met Glu Val Phe Trp Thr Ile Ile Met Ser 
        195                 200                 205             


Met Leu Leu Val Ile Pro Phe Leu Phe Ile Met Gly Thr Tyr Ile Leu 
    210                 215                 220                 


Val Leu Arg Ala Val Phe Arg Leu Pro Ser Arg Asp Gly Gln Lys Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr 
                245                 250                 255     


Cys Ser Val Met Lys Met Tyr Leu Ser Pro Thr Ser Glu His Glu Ala 
            260                 265                 270         


Gly Met Gln Lys Leu Val Thr Leu Phe Tyr Ser Val Gly Thr Pro Leu 
        275                 280                 285             


Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asn Ala 
    290                 295                 300                 


Leu Gln Lys Ile Leu Arg Thr 
305                 310     


<210>  15
<211>  918
<212>  DNA
<213>  Mus musculus

<400>  15
atggaactga acaggaccca gctgactgaa tttgttctca gaggaataac agatcgttca       60

gagctgcaag tccccctgtt cctggtgttc tttctcatct atgttatcac catggtgggc      120

aaccttggct taatctttgt catctggaag gaccctcatc ttcacacacc catgtacctt      180

ttccttggaa atttggcctt tgctgatgcc tgtaattcat cctctgtgac accaaagatg      240

cttatgaaat ttttaaataa gaatgacatg atatccatgg gtgagtgttt tgctcaattt      300

tatttctttt gttcaagtgt aactgcagaa gccttcattc tggtagctat ggcctatgac      360

cgctatgtag ccatatgcaa acctctgctc tatgtagtgg tgatgtccaa cagactctgt      420

attcagttca taggtgtatc ctatctaatt ggacttctac atggcttact tcatgtagga      480

ttgttattta ggttaacgtt ttgtagttcc aatgtaatag attatttcta ctgtgacatc      540

ctgccacttt ataggatttc ttgcactgac ccatcgatca atgtactggt agctttcatt      600

atgggtattt tattacaagt gagtaccttt atgagtatta tagtctccta tgtccgtgtc      660

ctctttgcca tcctgagaac aaagtctgag aggggcagaa acaaagcctt ctctacttgc      720

agttcccacc tgtcatctgt gtctttgttc tatggcactc tcttcatcat atatgtcctc      780

tctggctctg acacagataa ttatcagggt aaaatgtatt cactgttcta taccattatc      840

attcctctgc taaacccctt catttacagc ctaagaaata aagaagtcat cggtgccttg      900

agaaaagtca gaaaatga                                                    918


<210>  16
<211>  305
<212>  PRT
<213>  Mus musculus

<400>  16

Met Glu Leu Asn Arg Thr Gln Leu Thr Glu Phe Val Leu Arg Gly Ile 
1               5                   10                  15      


Thr Asp Arg Ser Glu Leu Gln Val Pro Leu Phe Leu Val Phe Phe Leu 
            20                  25                  30          


Ile Tyr Val Ile Thr Met Val Gly Asn Leu Gly Leu Ile Phe Val Ile 
        35                  40                  45              


Trp Lys Asp Pro His Leu His Thr Pro Met Tyr Leu Phe Leu Gly Asn 
    50                  55                  60                  


Leu Ala Phe Ala Asp Ala Cys Asn Ser Ser Ser Val Thr Pro Lys Met 
65                  70                  75                  80  


Leu Met Lys Phe Leu Asn Lys Asn Asp Met Ile Ser Met Gly Glu Cys 
                85                  90                  95      


Phe Ala Gln Phe Tyr Phe Phe Cys Ser Ser Val Thr Ala Glu Ala Phe 
            100                 105                 110         


Ile Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 
        115                 120                 125             


Leu Leu Tyr Val Val Val Met Ser Asn Arg Leu Cys Ile Gln Phe Ile 
    130                 135                 140                 


Gly Val Ser Tyr Leu Ile Gly Leu Leu His Gly Leu Leu His Val Gly 
145                 150                 155                 160 


Leu Leu Phe Arg Leu Thr Phe Cys Ser Ser Asn Val Ile Asp Tyr Phe 
                165                 170                 175     


Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Ile Ser Cys Thr Asp Pro Ser 
            180                 185                 190         


Ile Asn Val Leu Val Ala Phe Ile Met Gly Ile Leu Leu Gln Val Ser 
        195                 200                 205             


Thr Phe Met Ser Ile Ile Val Ser Tyr Val Arg Val Leu Phe Ala Ile 
    210                 215                 220                 


Leu Arg Thr Lys Ser Glu Arg Gly Arg Asn Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Ser Ser His Leu Ser Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe Ile 
                245                 250                 255     


Ile Tyr Val Leu Ser Gly Ser Asp Thr Asp Asn Tyr Gln Gly Lys Met 
            260                 265                 270         


Tyr Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Ile Gly Ala Leu Arg Lys Val Arg 
    290                 295                 300                 


Lys 
305 


<210>  17
<211>  951
<212>  DNA
<213>  Mus musculus

<400>  17
atgcctgggg tcaatacctc cagcctgaca ccaagatact ttattctcaa tgggattcct       60

gggttggaag ctgcacacat ctggatctct ctgccattct tcattatgta cctcattgct      120

gtcacaggta actgtggact tatctacctc atcagtcatg aggaggctct gcaccggccc      180

atgtactact ttctagccat gttgtctgct acagatattt ctgggtgtaa tacaattgtc      240

cccagtatgt tatgcatctt ttggttcagt gtcaaggaga ttgatttcaa tgcctgcctt      300

gtacagatgt ttttcatcca catgttaaca ggcatggagt ctggtgtgct catgcttatg      360

gctctcgacc gctatgtggc tatatgctat ccattacgct atactaccat actcaccaac      420

actatgatta ccaagattgg attggcagca cttgttagaa gtgtgttact catggtccct      480

tttgctttcc tgatcaagcg tcttccatac tgtagaggaa acctcatcca acatacctat      540

tgtgatcaca tggctgtggc taaactatcc tgtggcaata ttaagattaa tgctatctat      600

ggtcttataa ttgctatatt tattgggggt tttgatatat tctgtatctc catgtcttat      660

gccatgatta tccatgctgt ggtgaagcta tcttcggcag atgctcgcca taaagccttc      720

agtacctgta catcacacat atgtgctatt gttattacct atgtcccagc attcttcaac      780

ttctttactc atcgctttgg gagaaccact ataccccatc atatccacat tattatagcc      840

aacctgtatc tattgctacc tcccaccttg aatccaattg tatatggagt aaagaccaag      900

cagattcgtg aaggtgtgat caaactgttt gctagacaaa aagttgtttg a               951


<210>  18
<211>  316
<212>  PRT
<213>  Mus musculus

<400>  18

Met Pro Gly Val Asn Thr Ser Ser Leu Thr Pro Arg Tyr Phe Ile Leu 
1               5                   10                  15      


Asn Gly Ile Pro Gly Leu Glu Ala Ala His Ile Trp Ile Ser Leu Pro 
            20                  25                  30          


Phe Phe Ile Met Tyr Leu Ile Ala Val Thr Gly Asn Cys Gly Leu Ile 
        35                  40                  45              


Tyr Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 
    50                  55                  60                  


Leu Ala Met Leu Ser Ala Thr Asp Ile Ser Gly Cys Asn Thr Ile Val 
65                  70                  75                  80  


Pro Ser Met Leu Cys Ile Phe Trp Phe Ser Val Lys Glu Ile Asp Phe 
                85                  90                  95      


Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Met Leu Thr Gly Met 
            100                 105                 110         


Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Thr Met Ile Thr 
    130                 135                 140                 


Lys Ile Gly Leu Ala Ala Leu Val Arg Ser Val Leu Leu Met Val Pro 
145                 150                 155                 160 


Phe Ala Phe Leu Ile Lys Arg Leu Pro Tyr Cys Arg Gly Asn Leu Ile 
                165                 170                 175     


Gln His Thr Tyr Cys Asp His Met Ala Val Ala Lys Leu Ser Cys Gly 
            180                 185                 190         


Asn Ile Lys Ile Asn Ala Ile Tyr Gly Leu Ile Ile Ala Ile Phe Ile 
        195                 200                 205             


Gly Gly Phe Asp Ile Phe Cys Ile Ser Met Ser Tyr Ala Met Ile Ile 
    210                 215                 220                 


His Ala Val Val Lys Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Cys Thr Ser His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro 
                245                 250                 255     


Ala Phe Phe Asn Phe Phe Thr His Arg Phe Gly Arg Thr Thr Ile Pro 
            260                 265                 270         


His His Ile His Ile Ile Ile Ala Asn Leu Tyr Leu Leu Leu Pro Pro 
        275                 280                 285             


Thr Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu 
    290                 295                 300                 


Gly Val Ile Lys Leu Phe Ala Arg Gln Lys Val Val 
305                 310                 315     


<210>  19
<211>  954
<212>  DNA
<213>  Mus musculus

<400>  19
atgctgattt ccaacaactc atatgaagcc ccgcagtctt tcattcttaa tggaattcct       60

ggtctcgaag cagtgcatat atggatctct cttccactct gtacaatgta catcatctcc      120

ctagtaggca accttggcct tgtatatctc atttactatg aggaatcctt acatcgccca      180

atgtatttct ttctggccat gctttctctc atagacctgt ttacttgcac aaccactgtc      240

cccaatgccc tcttcatttt ctggttcaaa ctcaaggaaa ttaacttcac tgcttgccta      300

gttcagatgt tctttgtgca cggattcaca ggtgtggagt ctggggtact catgctcatg      360

gccttggacc gctatgtggc catttgctac ccactacgct atgcaaccat acttaccaac      420

cctgtcattg ccaaagctgg gcttgccacc ttcttgagag gtgtgttact gatgattcct      480

tttccattct tggttaaacg tttgcccttc tgccgaagca atgtcatctc ccatacatat      540

tgtgaccaca tgtctgtggt aaagttatcc tgtgccagca tcaaaatcaa tgtcatctat      600

ggtctcatgg ttgcacttct gattggagtg tttgacatat gttgtatatc tgtgtcctac      660

actatgatcc tccgggcagt ggtcagcctg tcctctgcag atgctcggca gaaggccttc      720

agcacctgca cagcccacat atctgccatc atcattactt atgttccagc cttcttcacc      780

ttctttactc atcgttttgg aggtcacacc atccctcctt ctcttcatat cattgtggct      840

aatctttatc ttcttctccc tccaactcta aatcccattg tttatgggat gaagaccaaa      900

cagatcagag atagtatcat taaattcttt cacggtgaaa aaggttcaag gtga            954


<210>  20
<211>  317
<212>  PRT
<213>  Mus musculus

<400>  20

Met Leu Ile Ser Asn Asn Ser Tyr Glu Ala Pro Gln Ser Phe Ile Leu 
1               5                   10                  15      


Asn Gly Ile Pro Gly Leu Glu Ala Val His Ile Trp Ile Ser Leu Pro 
            20                  25                  30          


Leu Cys Thr Met Tyr Ile Ile Ser Leu Val Gly Asn Leu Gly Leu Val 
        35                  40                  45              


Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His Arg Pro Met Tyr Phe Phe 
    50                  55                  60                  


Leu Ala Met Leu Ser Leu Ile Asp Leu Phe Thr Cys Thr Thr Thr Val 
65                  70                  75                  80  


Pro Asn Ala Leu Phe Ile Phe Trp Phe Lys Leu Lys Glu Ile Asn Phe 
                85                  90                  95      


Thr Ala Cys Leu Val Gln Met Phe Phe Val His Gly Phe Thr Gly Val 
            100                 105                 110         


Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala 
    130                 135                 140                 


Lys Ala Gly Leu Ala Thr Phe Leu Arg Gly Val Leu Leu Met Ile Pro 
145                 150                 155                 160 


Phe Pro Phe Leu Val Lys Arg Leu Pro Phe Cys Arg Ser Asn Val Ile 
                165                 170                 175     


Ser His Thr Tyr Cys Asp His Met Ser Val Val Lys Leu Ser Cys Ala 
            180                 185                 190         


Ser Ile Lys Ile Asn Val Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 
        195                 200                 205             


Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 
    210                 215                 220                 


Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Cys Thr Ala His Ile Ser Ala Ile Ile Ile Thr Tyr Val Pro 
                245                 250                 255     


Ala Phe Phe Thr Phe Phe Thr His Arg Phe Gly Gly His Thr Ile Pro 
            260                 265                 270         


Pro Ser Leu His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro 
        275                 280                 285             


Thr Leu Asn Pro Ile Val Tyr Gly Met Lys Thr Lys Gln Ile Arg Asp 
    290                 295                 300                 


Ser Ile Ile Lys Phe Phe His Gly Glu Lys Gly Ser Arg 
305                 310                 315         


<210>  21
<211>  936
<212>  DNA
<213>  Mus musculus

<400>  21
atgcaaaacc agagttttgt aacagaattc atattccttg gactttcaca gaaccctaaa       60

gtccagaaaa tagtttttat tgtattttta tttgtctaca ttgcaactgt tgggggcaac      120

atgataattg tggtgaccat tgtctgtagc ccagcattga tagactgccc catgtacttc      180

tttttggcat tcttgtccct attggatgca tgcttctctt ctgtcatcac accaaagatg      240

gttgtggact ccctgtatga gaagaaaact atctcctttg aaggatgtat gatgcagtta      300

tttgctgagc acttccttgc agcagtagaa gtgattgtct tgacagccat ggcctatgac      360

cgctatgtag caatttgcaa gcccttgcac tactcttcca tcatgaactg gaggctctgt      420

ggcacactta tggggatagc atggacaggg ggcttcttgc attctatcat acaaattatc      480

ttcacgttgc aattgccctt ctgtggacca aatgtcatcg atcatttcat gtgtgacttg      540

ttcccattac tggaacttgc ctgcactgat actcatatct ttggcctttt agtggttgcc      600

aacagtgggt ctatctgcat cataatcttc tctattttgc tggtctccta tggtgtcatc      660

ctgttctctc tgaaagctca cagttctgaa gggcgatgga aagctctctc cacatgtgga      720

tcccacattg cagttgtggt tttgttcttt gtcccgtgta tatttattta tgcacgtcct      780

ccatctgctt tctcctttga taaaatggtg gcgatatttt atactatcct aactcccttg      840

ctcaatcctg tgatttatac ttttcggaat aaggacatga aaaatgctat gaagaaagtg      900

tggaagaggt tggcagtggt ttctgatgga aagtga                                936


<210>  22
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  22

Met Gln Asn Gln Ser Phe Val Thr Glu Phe Ile Phe Leu Gly Leu Ser 
1               5                   10                  15      


Gln Asn Pro Lys Val Gln Lys Ile Val Phe Ile Val Phe Leu Phe Val 
            20                  25                  30          


Tyr Ile Ala Thr Val Gly Gly Asn Met Ile Ile Val Val Thr Ile Val 
        35                  40                  45              


Cys Ser Pro Ala Leu Ile Asp Cys Pro Met Tyr Phe Phe Leu Ala Phe 
    50                  55                  60                  


Leu Ser Leu Leu Asp Ala Cys Phe Ser Ser Val Ile Thr Pro Lys Met 
65                  70                  75                  80  


Val Val Asp Ser Leu Tyr Glu Lys Lys Thr Ile Ser Phe Glu Gly Cys 
                85                  90                  95      


Met Met Gln Leu Phe Ala Glu His Phe Leu Ala Ala Val Glu Val Ile 
            100                 105                 110         


Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 
        115                 120                 125             


Leu His Tyr Ser Ser Ile Met Asn Trp Arg Leu Cys Gly Thr Leu Met 
    130                 135                 140                 


Gly Ile Ala Trp Thr Gly Gly Phe Leu His Ser Ile Ile Gln Ile Ile 
145                 150                 155                 160 


Phe Thr Leu Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe 
                165                 170                 175     


Met Cys Asp Leu Phe Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr His 
            180                 185                 190         


Ile Phe Gly Leu Leu Val Val Ala Asn Ser Gly Ser Ile Cys Ile Ile 
        195                 200                 205             


Ile Phe Ser Ile Leu Leu Val Ser Tyr Gly Val Ile Leu Phe Ser Leu 
    210                 215                 220                 


Lys Ala His Ser Ser Glu Gly Arg Trp Lys Ala Leu Ser Thr Cys Gly 
225                 230                 235                 240 


Ser His Ile Ala Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Ile 
                245                 250                 255     


Tyr Ala Arg Pro Pro Ser Ala Phe Ser Phe Asp Lys Met Val Ala Ile 
            260                 265                 270         


Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Phe 
        275                 280                 285             


Arg Asn Lys Asp Met Lys Asn Ala Met Lys Lys Val Trp Lys Arg Leu 
    290                 295                 300                 


Ala Val Val Ser Asp Gly Lys 
305                 310     


<210>  23
<211>  975
<212>  DNA
<213>  Homo sapiens

<400>  23
atgcctctat ttaattcatt atgctggttt ccaacaattc atgtgactcc tccatctttt       60

attcttaatg gaatacctgg tctggaaaga gtacatgtat ggatctccct cccactctgc      120

acaatgtaca tcatcttcct tgtggggaat cttggtcttg tgtacctcat ttattatgag      180

gagtccttac atcatccgat gtattttttt tttggccatg ctctctccct cattgacctc      240

cttacctgca ccaccactct acccaatgca ctctgcatct tctggttcag tctcaaagaa      300

attaacttca atgcttgctt ggcccagatg ttctttgttc atgggttcac aggtgtggag      360

tctggggtgc tcatgctcat ggctctagac cgctatgtag ccatttgcta ccctttgcgt      420

tatgctacca cactcaccaa ccctatcatt gccaaggctg agcttgccac cttcctgagg      480

ggtgtattgc tgatgattcc tttcccattc ttggttaagc gtttgccttt ctgccaaagc      540

aatattatct cccatacgta ctgcgaccac atgtctgtag taaagctatc ttgtgccagc      600

atcaaggtca atgtaatcta tggtctaatg gttgctctcc tgattggagt gtttgacatt      660

tgttgtatat ctttgtctta cactttgatc ctcaaggcag cgatcagcct ctcttcatca      720

gatgctcggc agaaggcttt cagcacctgc actgcccata tatctgccat catcatcacc      780

tatgttccag cattcttcac tttctttgcc caccgttttg ggggacacac aattccccct      840

tctcttcaca tcattgtggc taatctttat cttcttcttc ccccaactct aaaccctatt      900

gtttatggag taaagacaaa acagatacgc aagagtgtca taaagttctt ccagggtgat      960

aagggtgcag gttga                                                       975


<210>  24
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Leu Phe Asn Ser Leu Cys Trp Phe Pro Thr Ile His Val Thr 
1               5                   10                  15      


Pro Pro Ser Phe Ile Leu Asn Gly Ile Pro Gly Leu Glu Arg Val His 
            20                  25                  30          


Val Trp Ile Ser Leu Pro Leu Cys Thr Met Tyr Ile Ile Phe Leu Val 
        35                  40                  45              


Gly Asn Leu Gly Leu Val Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His 
    50                  55                  60                  


His Pro Met Tyr Phe Phe Phe Gly His Ala Leu Ser Leu Ile Asp Leu 
65                  70                  75                  80  


Leu Thr Cys Thr Thr Thr Leu Pro Asn Ala Leu Cys Ile Phe Trp Phe 
                85                  90                  95      


Ser Leu Lys Glu Ile Asn Phe Asn Ala Cys Leu Ala Gln Met Phe Phe 
            100                 105                 110         


Val His Gly Phe Thr Gly Val Glu Ser Gly Val Leu Met Leu Met Ala 
        115                 120                 125             


Leu Asp Arg Tyr Val Ala Ile Cys Tyr Pro Leu Arg Tyr Ala Thr Thr 
    130                 135                 140                 


Leu Thr Asn Pro Ile Ile Ala Lys Ala Glu Leu Ala Thr Phe Leu Arg 
145                 150                 155                 160 


Gly Val Leu Leu Met Ile Pro Phe Pro Phe Leu Val Lys Arg Leu Pro 
                165                 170                 175     


Phe Cys Gln Ser Asn Ile Ile Ser His Thr Tyr Cys Asp His Met Ser 
            180                 185                 190         


Val Val Lys Leu Ser Cys Ala Ser Ile Lys Val Asn Val Ile Tyr Gly 
        195                 200                 205             


Leu Met Val Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Leu Ile Leu Lys Ala Ala Ile Ser Leu Ser Ser Ser 
225                 230                 235                 240 


Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys Thr Ala His Ile Ser Ala 
                245                 250                 255     


Ile Ile Ile Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg 
            260                 265                 270         


Phe Gly Gly His Thr Ile Pro Pro Ser Leu His Ile Ile Val Ala Asn 
        275                 280                 285             


Leu Tyr Leu Leu Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Val 
    290                 295                 300                 


Lys Thr Lys Gln Ile Arg Lys Ser Val Ile Lys Phe Phe Gln Gly Asp 
305                 310                 315                 320 


Lys Gly Ala Gly 
                


<210>  25
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  25
atggagaaat ggaatcacac ttcaaatgat ttcattttgt tgggtctgct tcccccaaat       60

caaactggaa tatttctctt gtgccttatc atcctcatat tctttctggc ctcggtgggt      120

aactcggcca tgattcacct catccacgtg gatcctcgtc tccacacacc gatgtacttt      180

cttctcagcc agctctccct tatggacctg atgtacatct ccaccaccgt ccccaagatg      240

gcgtacaact tcctgtccgg ccagaaaggc atctccttcc tgggatgtgg tgtgcaaagc      300

ttcttcttcc tgaccatggc gtgttctgaa ggcttactcc tgacctccat ggcctacgac      360

cgttatttgg ccatctgcca ctctctctat tatcctatcc gcatgagtaa aatgatgtgt      420

gtgaagatga ttggaggctc ttggacactg gggtccatca actccttggc acacacagtc      480

tttgcccttc atattcccta ctgcaggtct agggctattg accatttctt ctgcgatgtc      540

ccagccatgt tgcttcttgc ctgtacagat acttgggtct atgaatatat ggtttttgta      600

agtacaagcc tctttctcct tttccctttc attggcatca cttcttcctg tggccgagtc      660

ctatttgctg tctatcatat gcactcaaag gaggggagaa aaaaggcctt caccaccatt      720

tcaacacatt taactgtagt gatcttttac tatgcacctt ttgtctacac ctatcttcgg      780

cccaggaatc tccgctcacc agctgaagac aagatcctgg cagtcttcta caccatcctt      840

acccccatgc tcaatcccat tatctacagc ctgaggaata aggaagtcct gggggctatg      900

aggagagtgt ttgggatatt ctctttcctg aaagaataa                             939


<210>  26
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu 
1               5                   10                  15      


Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu 
            20                  25                  30          


Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile 
        35                  40                  45              


His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 
    50                  55                  60                  


Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 
65                  70                  75                  80  


Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys 
                85                  90                  95      


Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 
            100                 105                 110         


Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser 
        115                 120                 125             


Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile 
    130                 135                 140                 


Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 
145                 150                 155                 160 


Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe 
                165                 170                 175     


Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp 
            180                 185                 190         


Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe 
        195                 200                 205             


Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val 
    210                 215                 220                 


Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile 
225                 230                 235                 240 


Ser Thr His Leu Thr Val Val Ile Phe Tyr Tyr Ala Pro Phe Val Tyr 
                245                 250                 255     


Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile 
            260                 265                 270         


Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Arg Arg Val Phe 
    290                 295                 300                 


Gly Ile Phe Ser Phe Leu Lys Glu 
305                 310         


<210>  27
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  27
atgagtgtaa cagaaaatac gctcatgatc ctcctcattc gcagtgactc ccgactccac       60

actccaatgt attttctgct cagccatctc tccttaatgg atatcttgca tgtttccaac      120

atcgttccca aaatggtcac taactttctg tcaggcagca gaactatttc atttgcaggt      180

tgtgggttcc aggtatttct gtccctcacc ctcctgggtg gtgagtgcct tctcctggct      240

gcaatgtcct gtgatcgcta tgtggctatc tgtcacccgc tgcgctatcc gattcttatg      300

aaggagtatg ccagcgctct catggctgga ggctcctggc tcattggggt tttcaactcc      360

acagtccaca cagcttatgc actgcagttt cccttctgtg gctctagggc aattgatcac      420

ttcttctgtg aagtccctgc catgttgaag ttgtcctgtg cagacacaac acgctatgaa      480

cgaggggttt gtgtaagtgc tgtgatcttc ctgctgatcc ctttctcctt gatctctgct      540

tcttatggcc aaattattct tactgtcctc cagatgaaat catcagaggc aaggaaaaag      600

tcattttcca cttgttcctt ccacatgatt gtggtcacga tgtactatgg gccatttatt      660

tttacatata tgagacctaa atcataccac actccagggc aggataagtt cctggcaata      720

ttctatacga tcctcacacc cacactcaac cctttcatct acagctttag gaataaagat      780

gttctggcgg tgatgaaaaa tatgctcaaa agtaactttc tgcacaaaaa aatgaatagg      840

aaaattcctg aatgtgtgtt ctgtctattt ctatgttaa                             879


<210>  28
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu Ile Arg Ser Asp 
1               5                   10                  15      


Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser Leu 
            20                  25                  30          


Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys Met Val Thr Asn 
        35                  40                  45              


Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly Cys Gly Phe Gln 
    50                  55                  60                  


Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys Leu Leu Leu Ala 
65                  70                  75                  80  


Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 
                85                  90                  95      


Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met Ala Gly Gly Ser 
            100                 105                 110         


Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr Ala Tyr Ala Leu 
        115                 120                 125             


Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His Phe Phe Cys Glu 
    130                 135                 140                 


Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr Thr Arg Tyr Glu 
145                 150                 155                 160 


Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu Ile Pro Phe Ser 
                165                 170                 175     


Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr Val Leu Gln Met 
            180                 185                 190         


Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr Cys Ser Phe His 
        195                 200                 205             


Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile Phe Thr Tyr Met 
    210                 215                 220                 


Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys Phe Leu Ala Ile 
225                 230                 235                 240 


Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe Ile Tyr Ser Phe 
                245                 250                 255     


Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met Leu Lys Ser Asn 
            260                 265                 270         


Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu Cys Val Phe Cys 
        275                 280                 285             


Leu Phe Leu Cys 
    290         


<210>  29
<211>  1113
<212>  DNA
<213>  Homo sapiens

<400>  29
atgttctcaa tgacaacaga agcactcaat aattttgcac ttggatgtac caacttgtta       60

atgactatga taccacaaat tgatctgaag caaattttcc tttgtcctaa ttgcagacta      120

tacatgatcc ctgttggagc tttcatcttt tccttgggaa acatgcaaaa ccaaagcttt      180

gtaactgagt ttgtcctcct gggactttca cagaatccaa atgttcagga aatagtattt      240

gttgtatttt tgtttgtcta cattgcaact gttgggggca acatgctaat tgtagtaacc      300

attctcagca gccctgctct tctggtgtct cctatgtact tcttcttggg cttcctgtcc      360

ttcctggatg cgtgcttctc atctgtcatc accccaaaga tgattgtaga ctccctctat      420

gtgacaaaaa ccatctcttt tgaaggctgc atgatgcagc tctttgctga acacttcttt      480

gctggggtgg aggtgattgt cctcacagcc atggcctatg atcgttatgt ggccatttgc      540

aagcccttgc attactcttc tatcatgaac aggaggctct gtggcattct gatgggggta      600

gcctggacag ggggcctctt gcattccatg atacaaattc tttttacttt ccagcttccc      660

ttttgtggcc ccaatgtcat caatcacttt atgtgtgact tgtacccgtt actggagctt      720

gcctgcactg atactcacat ctttggcctc atggtggtca tcaacagtgg gtttatctgc      780

atcataaact tctccttgtt gcttgtctcc tatgctgtca tcttgctctc tctgagaaca      840

cacagttctg aagggcgctg gaaagctctc tccacctgtg gatctcacat tgctgttgtg      900

attttgttct ttgtcccatg catatttgta tatacacgac ctccatctgc tttttccctt      960

gacaaaatgg cggcaatatt ttatatcatc ttaaatccct tgctcaatcc tttgatttac     1020

actttcagga ataaggaagt aaaacaggcc atgaggagaa tatggaacag actgatggtg     1080

gtttctgatg agaaagaaaa tattaaactt taa                                  1113


<210>  30
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Phe Ser Met Thr Thr Glu Ala Leu Asn Asn Phe Ala Leu Gly Cys 
1               5                   10                  15      


Thr Asn Leu Leu Met Thr Met Ile Pro Gln Ile Asp Leu Lys Gln Ile 
            20                  25                  30          


Phe Leu Cys Pro Asn Cys Arg Leu Tyr Met Ile Pro Val Gly Ala Phe 
        35                  40                  45              


Ile Phe Ser Leu Gly Asn Met Gln Asn Gln Ser Phe Val Thr Glu Phe 
    50                  55                  60                  


Val Leu Leu Gly Leu Ser Gln Asn Pro Asn Val Gln Glu Ile Val Phe 
65                  70                  75                  80  


Val Val Phe Leu Phe Val Tyr Ile Ala Thr Val Gly Gly Asn Met Leu 
                85                  90                  95      


Ile Val Val Thr Ile Leu Ser Ser Pro Ala Leu Leu Val Ser Pro Met 
            100                 105                 110         


Tyr Phe Phe Leu Gly Phe Leu Ser Phe Leu Asp Ala Cys Phe Ser Ser 
        115                 120                 125             


Val Ile Thr Pro Lys Met Ile Val Asp Ser Leu Tyr Val Thr Lys Thr 
    130                 135                 140                 


Ile Ser Phe Glu Gly Cys Met Met Gln Leu Phe Ala Glu His Phe Phe 
145                 150                 155                 160 


Ala Gly Val Glu Val Ile Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr 
                165                 170                 175     


Val Ala Ile Cys Lys Pro Leu His Tyr Ser Ser Ile Met Asn Arg Arg 
            180                 185                 190         


Leu Cys Gly Ile Leu Met Gly Val Ala Trp Thr Gly Gly Leu Leu His 
        195                 200                 205             


Ser Met Ile Gln Ile Leu Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro 
    210                 215                 220                 


Asn Val Ile Asn His Phe Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu 
225                 230                 235                 240 


Ala Cys Thr Asp Thr His Ile Phe Gly Leu Met Val Val Ile Asn Ser 
                245                 250                 255     


Gly Phe Ile Cys Ile Ile Asn Phe Ser Leu Leu Leu Val Ser Tyr Ala 
            260                 265                 270         


Val Ile Leu Leu Ser Leu Arg Thr His Ser Ser Glu Gly Arg Trp Lys 
        275                 280                 285             


Ala Leu Ser Thr Cys Gly Ser His Ile Ala Val Val Ile Leu Phe Phe 
    290                 295                 300                 


Val Pro Cys Ile Phe Val Tyr Thr Arg Pro Pro Ser Ala Phe Ser Leu 
305                 310                 315                 320 


Asp Lys Met Ala Ala Ile Phe Tyr Ile Ile Leu Asn Pro Leu Leu Asn 
                325                 330                 335     


Pro Leu Ile Tyr Thr Phe Arg Asn Lys Glu Val Lys Gln Ala Met Arg 
            340                 345                 350         


Arg Ile Trp Asn Arg Leu Met Val Val Ser Asp Glu Lys Glu Asn Ile 
        355                 360                 365             


Lys Leu 
    370 


<210>  31
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  31
atggatatat cagagggaaa taagactctt gtgacagagt ttgttctcac aggacttaca       60

gatcgaccat ggctgcacgt cctcttcttt gttgtgtttt tggtggtcta tctcatcacc      120

atggtgggca accttggact gatagttcta atttggaacg acccccatct tcatatgccc      180

atgtacttat tccttggtgg tttagccttt tcagatgctt gtacttcaac ctctataacc      240

cctaggatgc tggtcaattt cttagacaag actgcaatga tatccctagc tgagtgcatc      300

acccagtttt acttttttgc ttccagtgca actacagaat gcttcctcct ggtgatgatg      360

gcctatgacc gctatgtagc catatgtaat cccttgcttt atccagtgat gatgtccaac      420

aaactcagcg ctcagttgct aagtatttca tatgtaattg gtttcctgca tcctctggtt      480

catgtgagtt tactattgcg actaactttc tgcaggttta acataataca ttatttctac      540

tgtgaaattt tacaactgtt caaaatttca tgcaatggtc catctattaa cgcactaatg      600

atatttattt ttggtgcttt tatacaaata cccactttaa tgactatcat aatctcttat      660

actcgtgtgc tctttgatat tctgaaaaaa aagtctgaaa agggcagaag caaagccttc      720

tccacatgcg gcgcccatct gctttctgtc tcattgtact acggaactct gatcttcatg      780

tatgtgcgtc ctgcatctgg cttagctgaa gaccaagaca aagtgtattc tctgttttac      840

acgattataa ttcccctgct aaacccattt atttacagct tgagaaataa aaaagtcatg      900

catgcattga gaagagttat aaggaagtaa                                       930


<210>  32
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Ile Ser Glu Gly Asn Lys Thr Leu Val Thr Glu Phe Val Leu 
1               5                   10                  15      


Thr Gly Leu Thr Asp Arg Pro Trp Leu His Val Leu Phe Phe Val Val 
            20                  25                  30          


Phe Leu Val Val Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Ile 
        35                  40                  45              


Val Leu Ile Trp Asn Asp Pro His Leu His Met Pro Met Tyr Leu Phe 
    50                  55                  60                  


Leu Gly Gly Leu Ala Phe Ser Asp Ala Cys Thr Ser Thr Ser Ile Thr 
65                  70                  75                  80  


Pro Arg Met Leu Val Asn Phe Leu Asp Lys Thr Ala Met Ile Ser Leu 
                85                  90                  95      


Ala Glu Cys Ile Thr Gln Phe Tyr Phe Phe Ala Ser Ser Ala Thr Thr 
            100                 105                 110         


Glu Cys Phe Leu Leu Val Met Met Ala Tyr Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Asn Pro Leu Leu Tyr Pro Val Met Met Ser Asn Lys Leu Ser Ala 
    130                 135                 140                 


Gln Leu Leu Ser Ile Ser Tyr Val Ile Gly Phe Leu His Pro Leu Val 
145                 150                 155                 160 


His Val Ser Leu Leu Leu Arg Leu Thr Phe Cys Arg Phe Asn Ile Ile 
                165                 170                 175     


His Tyr Phe Tyr Cys Glu Ile Leu Gln Leu Phe Lys Ile Ser Cys Asn 
            180                 185                 190         


Gly Pro Ser Ile Asn Ala Leu Met Ile Phe Ile Phe Gly Ala Phe Ile 
        195                 200                 205             


Gln Ile Pro Thr Leu Met Thr Ile Ile Ile Ser Tyr Thr Arg Val Leu 
    210                 215                 220                 


Phe Asp Ile Leu Lys Lys Lys Ser Glu Lys Gly Arg Ser Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Thr 
                245                 250                 255     


Leu Ile Phe Met Tyr Val Arg Pro Ala Ser Gly Leu Ala Glu Asp Gln 
            260                 265                 270         


Asp Lys Val Tyr Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn 
        275                 280                 285             


Pro Phe Ile Tyr Ser Leu Arg Asn Lys Lys Val Met His Ala Leu Arg 
    290                 295                 300                 


Arg Val Ile Arg Lys 
305                 


<210>  33
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  33
atgatgggta gaaggaatga cacaaatgtg gctgacttca tccttacggg actgtcagac       60

tctgaagagg tccagatggc tctgtttatg ctatttctcc tcatatacct aattactatg      120

ctggggaatg tggggatgct attgataatc cgcctggacc tccagcttca cactcccatg      180

tattttttcc ttactcacct gtcatttatt gacctcagtt actcaactgt cgtcacacct      240

aaaaccttag cgaacttact gacttccaac tatatttcct tcacgggctg ctttgcccag      300

atgttctgtt ttgtcttctt gggtactgct gaatgttatc ttctctcctc aatggcctat      360

gatcgctatg cagcgatctg cagtcctcta cactacacag ttattatgcc caaaaggctc      420

tgcctcgctc tcatcactgg gccttatgtg attggcttta tggactcctt tgtcaatgtg      480

gtttccatga gcagattgca tttctgtgac tcaaacataa ttcatcactt tttctgtgac      540

acttccccaa ttttagctct gtcctgcact gacacagaca acactgaaat gctgatattc      600

attatcgctg gttccaccct gatggtgtcc cttatcacaa tatctgcatc ctatgtgtcc      660

attctctcta ccatcctgaa aattaattcc acttcaggaa agcagaaagc tttctctact      720

tgcgtctctc atctcttggg agtcaccatc ttctatggaa ctatgatttt tacttactta      780

aagccaagaa agtcttattc cttgggaaga gatcaagtgg ctcctgtgtt ttatactatt      840

gtgattccca tgctgaatcc actcatttat agtcttagaa acagagaagt gaaaaatgct      900

ctcattagag tcatgcagag aagacaggac tccaggtag                             939


<210>  34
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Met Gly Arg Arg Asn Asp Thr Asn Val Ala Asp Phe Ile Leu Thr 
1               5                   10                  15      


Gly Leu Ser Asp Ser Glu Glu Val Gln Met Ala Leu Phe Met Leu Phe 
            20                  25                  30          


Leu Leu Ile Tyr Leu Ile Thr Met Leu Gly Asn Val Gly Met Leu Leu 
        35                  40                  45              


Ile Ile Arg Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Thr His Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Val Thr Pro 
65                  70                  75                  80  


Lys Thr Leu Ala Asn Leu Leu Thr Ser Asn Tyr Ile Ser Phe Thr Gly 
                85                  90                  95      


Cys Phe Ala Gln Met Phe Cys Phe Val Phe Leu Gly Thr Ala Glu Cys 
            100                 105                 110         


Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Ser 
        115                 120                 125             


Pro Leu His Tyr Thr Val Ile Met Pro Lys Arg Leu Cys Leu Ala Leu 
    130                 135                 140                 


Ile Thr Gly Pro Tyr Val Ile Gly Phe Met Asp Ser Phe Val Asn Val 
145                 150                 155                 160 


Val Ser Met Ser Arg Leu His Phe Cys Asp Ser Asn Ile Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Thr Ser Pro Ile Leu Ala Leu Ser Cys Thr Asp Thr 
            180                 185                 190         


Asp Asn Thr Glu Met Leu Ile Phe Ile Ile Ala Gly Ser Thr Leu Met 
        195                 200                 205             


Val Ser Leu Ile Thr Ile Ser Ala Ser Tyr Val Ser Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Asn Ser Thr Ser Gly Lys Gln Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Val Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile 
                245                 250                 255     


Phe Thr Tyr Leu Lys Pro Arg Lys Ser Tyr Ser Leu Gly Arg Asp Gln 
            260                 265                 270         


Val Ala Pro Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asn Ala Leu Ile Arg Val 
    290                 295                 300                 


Met Gln Arg Arg Gln Asp Ser Arg 
305                 310         


<210>  35
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  35
atgaaaatct tcaacagccc cagcaactcc agcaccttca ctggcttcat cctcctgggc       60

ttcccttgcc ccagggaggg gcagatcctc ctctttgtgc tcttcactgt tgtttacctc      120

ctgaccctca tgggcaatgg ttccatcatc tgtgctgtgc actgggatca gagactccac      180

gcccccatgt acatcctgct cgccaacttc tccttcttgg agatatgtta tgtcacctcc      240

acagtcccca gcatgctggc caacttcctc tctgacacca agatcatctc gttctctggc      300

tgcttcctcc agttctactt tttcttctcc ttgggctcta cagaatgctt tttcctggca      360

gttatggcat ttgatcgata ccttgccatc tgtcggcctc tacgctatcc aaccattatg      420

accagacgtc tctgtaccaa tcttgtggtc aattgctggg tacttggttt catctggttc      480

ttgattccta tcgtcaacat ctcccaaatg tccttctgtg gatctaggat tattgaccac      540

ttcctatgtg acccagctcc tcttctaact ctcacttgca aaaaaggccc tgtgatagag      600

cttgtctttt ctgtcttaag tcctctgcct gtctttatgc tctttctctt cattgtgggg      660

tcctatgctc tggtcgtgag agctgtgttg agggtccctt cagcagctgg gagaagaaag      720

gctttctcca cctgtgggtc tcacctggct gtggtttcac tgttctacgg ctcagtactg      780

gtcatgtatg ggagcccacc atctaagaat gaagctggaa agcagaagac tgtgactctg      840

ttttattctg ttgttacccc actgcttaac cctgtgatat atagtcttag gaacaaagat      900

atgagaaaag ctctgaagaa attttgggga acataa                                936


<210>  36
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 
        35                  40                  45              


Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro Met Tyr 
    50                  55                  60                  


Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Ile Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 
            100                 105                 110         


Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg Arg Leu 
    130                 135                 140                 


Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile Trp Phe 
145                 150                 155                 160 


Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr Leu Thr 
            180                 185                 190         


Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu Ser Pro 
        195                 200                 205             


Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr Ala Leu 
    210                 215                 220                 


Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg Arg Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 
                245                 250                 255     


Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn Glu Ala 
            260                 265                 270         


Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu 
        275                 280                 285             


Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg Lys Ala 
    290                 295                 300                 


Leu Lys Lys Phe Trp Gly Thr 
305                 310     


<210>  37
<211>  966
<212>  DNA
<213>  Homo sapiens

<400>  37
atgtctgggg acaacagctc cagcctgacc ccaggattct ttatcttgaa tggcgttcct       60

gggctggaag ccacacacat ctggatctcc ctgccattct gctttatgta catcattgct      120

gtcgtgggga actgtgggct catctgcctc atcagccatg aggaggccct gcaccggccc      180

atgtactact tcctggccct gctctccttc actgatgtca ccttgtgcac caccatggta      240

cctaatatgc tgtgcatatt ctggttcaac ctcaaggaga ttgactttaa cgcctgcctg      300

gcccagatgt tttttgtcca tatgctgaca gggatggagt ctggggtgct catgctcatg      360

gccctggacc gctatgtggc catctgctac cccttacgct atgccaccat ccttaccaac      420

cctgtcatcg ccaaggctgg tcttgccacc ttcttgagga atgtgatgct catcatccca      480

ttcactctcc tcaccaagcg cctgccctat tgccggggga acttcatccc ccacacctac      540

tgtgaccata tgtctgtggc caaggtatcc tgtggcaatt tcaaggtcaa tgctatttat      600

ggtctgatgg ttgctctcct gattggtgtg tttgatatct gctgtatctc tgtatcttac      660

actatgattt tgcaggctgt tatgagcctg tcatcagcag atgctcgtca caaagccttc      720

agcacctgca catctcacat gtgttccatt gtgatcacct atgttgctgc ttttttcact      780

tttttcactc atcgttttgt aggacacaat atcccaaacc acatacacat catcgtggcc      840

aacctttatc tgctactgcc tcctaccatg aacccaattg tttatggagt caagaccaag      900

cagattcagg aaggtgtaat taaattttta cttggagaca aggttagttt tacctatgac      960

aaatga                                                                 966


<210>  38
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Gly Asp Asn Ser Ser Ser Leu Thr Pro Gly Phe Phe Ile Leu 
1               5                   10                  15      


Asn Gly Val Pro Gly Leu Glu Ala Thr His Ile Trp Ile Ser Leu Pro 
            20                  25                  30          


Phe Cys Phe Met Tyr Ile Ile Ala Val Val Gly Asn Cys Gly Leu Ile 
        35                  40                  45              


Cys Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 
    50                  55                  60                  


Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Met Val 
65                  70                  75                  80  


Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe 
                85                  90                  95      


Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met 
            100                 105                 110         


Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 
        115                 120                 125             


Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala 
    130                 135                 140                 


Lys Ala Gly Leu Ala Thr Phe Leu Arg Asn Val Met Leu Ile Ile Pro 
145                 150                 155                 160 


Phe Thr Leu Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Phe Ile 
                165                 170                 175     


Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly 
            180                 185                 190         


Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 
        195                 200                 205             


Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 
    210                 215                 220                 


Gln Ala Val Met Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Cys Thr Ser His Met Cys Ser Ile Val Ile Thr Tyr Val Ala 
                245                 250                 255     


Ala Phe Phe Thr Phe Phe Thr His Arg Phe Val Gly His Asn Ile Pro 
            260                 265                 270         


Asn His Ile His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro 
        275                 280                 285             


Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu 
    290                 295                 300                 


Gly Val Ile Lys Phe Leu Leu Gly Asp Lys Val Ser Phe Thr Tyr Asp 
305                 310                 315                 320 


Lys 
    


<210>  39
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  39
atgtttatat taataagctt cacagaagaa tttgatgtgc aagtcttcct atttttatta       60

tttttagcaa tctatctatt cactctaata ggcaatttag ggctggttgt accgatcatt      120

ggggatttct ggcttcacag cccaatgtac tattttcttg gtgttttatc attcttggat      180

gtctgctatt ctacagttgt cactccaaaa atgttggtca atttcctggc aaaaaataaa      240

tctatttcat ttcttggatg tgcaacacag atgtttcttg cttgtacttt tggaaccaca      300

gaatgctttc tcttggctgc aatggcttat gatcgctatg tagccatcta caaccctctc      360

ctgtattcag tgagcatgtc acccagagtc tatgtgccac tcatcactgc ttcctatgtt      420

gctagcattt tacatgctac tatacataca gtggctacat ttagcctgtc cttctgtgga      480

tccaatgaaa ttaggcatgt cttttgtaat atgcctcctc tccttgctat ttcttgttct      540

gacactcacg taatccagct tctattcttc tactttgtgg gctctattga gatagtcact      600

atcctgattg tcctgatctc ctatggtttt attctgttgg ccattctgaa gatgcagtct      660

gctgaaggga ggagaaaagt cttctctaca tgtggagctc acctaactgg agtgacaatt      720

tatcatggga caatcctctt catgtatgtg agaccaagtt ccagctacac ttcggacaat      780

gacatgatag tgtcaatatt ttataccatt gtgattccca tgctgaatcc catcatctac      840

agtttgcgga acaaagatgt aaaggaggca atcaaaagat tgcttgtgag aaattggttc      900

ataaataagt tatag                                                       915


<210>  40
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Phe Ile Leu Ile Ser Phe Thr Glu Glu Phe Asp Val Gln Val Phe 
1               5                   10                  15      


Leu Phe Leu Leu Phe Leu Ala Ile Tyr Leu Phe Thr Leu Ile Gly Asn 
            20                  25                  30          


Leu Gly Leu Val Val Pro Ile Ile Gly Asp Phe Trp Leu His Ser Pro 
        35                  40                  45              


Met Tyr Tyr Phe Leu Gly Val Leu Ser Phe Leu Asp Val Cys Tyr Ser 
    50                  55                  60                  


Thr Val Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Lys Asn Lys 
65                  70                  75                  80  


Ser Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Phe Leu Ala Cys Thr 
                85                  90                  95      


Phe Gly Thr Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg 
            100                 105                 110         


Tyr Val Ala Ile Tyr Asn Pro Leu Leu Tyr Ser Val Ser Met Ser Pro 
        115                 120                 125             


Arg Val Tyr Val Pro Leu Ile Thr Ala Ser Tyr Val Ala Ser Ile Leu 
    130                 135                 140                 


His Ala Thr Ile His Thr Val Ala Thr Phe Ser Leu Ser Phe Cys Gly 
145                 150                 155                 160 


Ser Asn Glu Ile Arg His Val Phe Cys Asn Met Pro Pro Leu Leu Ala 
                165                 170                 175     


Ile Ser Cys Ser Asp Thr His Val Ile Gln Leu Leu Phe Phe Tyr Phe 
            180                 185                 190         


Val Gly Ser Ile Glu Ile Val Thr Ile Leu Ile Val Leu Ile Ser Tyr 
        195                 200                 205             


Gly Phe Ile Leu Leu Ala Ile Leu Lys Met Gln Ser Ala Glu Gly Arg 
    210                 215                 220                 


Arg Lys Val Phe Ser Thr Cys Gly Ala His Leu Thr Gly Val Thr Ile 
225                 230                 235                 240 


Tyr His Gly Thr Ile Leu Phe Met Tyr Val Arg Pro Ser Ser Ser Tyr 
                245                 250                 255     


Thr Ser Asp Asn Asp Met Ile Val Ser Ile Phe Tyr Thr Ile Val Ile 
            260                 265                 270         


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
        275                 280                 285             


Glu Ala Ile Lys Arg Leu Leu Val Arg Asn Trp Phe Ile Asn Lys Leu 
    290                 295                 300                 


<210>  41
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  41
atggaaaaaa taaacaacgt aactgaattc attttctggg gtctttctca gagcccagag       60

attgagaaag tttgttttgt ggtgttttct ttcttctaca taatcattct tctgggaaat      120

ctcctcatca tgctgacagt ttgcctgagc aacctgttta agtcacccat gtatttcttt      180

ctcagcttct tgtcttttgt ggacatttgt tactcttcag tcacagctcc caagatgatt      240

gttgacctgt tagcaaagga caaaaccatc tcctatgtgg ggtgcatgtt gcaactgttt      300

ggagtacatt tctttggttg cactgagatc ttcatcctta ctgtaatggc ctatgatcgt      360

tatgtggcta tctgtaaacc cctacattat atgaccatca tgaaccggga gacatgcaat      420

aaaatgttat tagggacgtg ggtaggtggg ttcttacact ccattatcca agtggctctg      480

gtagtccaac tacccttttg tggacccaat gagatagatc actacttttg tgatgttcac      540

cctgtgttga aacttgcctg cacagaaaca tacattgttg gtgttgttgt gacagccaac      600

agtggtacca ttgctctggg gagttttgtt atcttgctaa tctcctacag catcatccta      660

gtttccctga gaaagcagtc agcagaaggc aggcgcaaag ccctctccac ctgtggctcc      720

cacattgcca tggtcgttat ctttttcggc ccctgtactt ttatgtacat gcgccctgat      780

acgacctttt cagaggataa gatggtggct gtattttaca ccattatcac tcccatgtta      840

aatcctctga tttatacact gagaaatgca gaagtaaaga atgcaatgaa gaaactgtgg      900

ggcagaaatg ttttcttgga ggctaaaggg aaatag                                936


<210>  42
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Lys Ile Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser 
1               5                   10                  15      


Gln Ser Pro Glu Ile Glu Lys Val Cys Phe Val Val Phe Ser Phe Phe 
            20                  25                  30          


Tyr Ile Ile Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Cys 
        35                  40                  45              


Leu Ser Asn Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu 
    50                  55                  60                  


Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile 
65                  70                  75                  80  


Val Asp Leu Leu Ala Lys Asp Lys Thr Ile Ser Tyr Val Gly Cys Met 
                85                  90                  95      


Leu Gln Leu Phe Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile 
            100                 105                 110         


Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 
        115                 120                 125             


His Tyr Met Thr Ile Met Asn Arg Glu Thr Cys Asn Lys Met Leu Leu 
    130                 135                 140                 


Gly Thr Trp Val Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu 
145                 150                 155                 160 


Val Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 
                165                 170                 175     


Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Ile 
            180                 185                 190         


Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser 
        195                 200                 205             


Phe Val Ile Leu Leu Ile Ser Tyr Ser Ile Ile Leu Val Ser Leu Arg 
    210                 215                 220                 


Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 
225                 230                 235                 240 


His Ile Ala Met Val Val Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr 
                245                 250                 255     


Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe 
            260                 265                 270         


Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 
        275                 280                 285             


Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Gly Arg Asn Val 
    290                 295                 300                 


Phe Leu Glu Ala Lys Gly Lys 
305                 310     


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  43
gattacaagg acgacgacga taag                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  44

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  45
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rho tag

<400>  45
atgaacggga ccgagggccc aaacttctac gtgcctttct ccaacaagac gggcgtggtg       60


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rho tag

<400>  46

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Lys 
1               5                   10                  15      


Thr Gly Val Val 
            20  


<210>  47
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lucy tag

<400>  47
atgagacccc agatcctgct gctcctggcc ctgctgaccc taggcctggc t                51


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lucy tag

<400>  48

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala 
    


<210>  49
<211>  1376
<212>  DNA
<213>  Homo sapiens

<400>  49
atgggtctgt gctacagtct gcggccgctg cttttcgggg gcccagggga cgacccctgc       60

gcggcctcgg agccgccggt ggaggacgcg cagcccgccc cggccccggc cctggcccca      120

gtccgggcgg ccgcaaggga cacggcccgg accctgctcc ctcggggcgg cgaagggagc      180

ccggcatgcg ctcggcccaa agcagacaag ccgaaggaga agcggcagcg caccgagcag      240

cttagtgccg aggagcgcga ggcggccaag gagcgcgagg cggtcaagga ggcgaggaaa      300

gtgagccggg gcatcgaccg catgctgcgc gaccagaagc gcgacctgca gcagacgcac      360

cggctcctgc tgctcggggc tggtgagtct gggaaaagca ctatcgtcaa acagatgagg      420

atcctgcacg tcaatgggtt taatcccgag gaaaagaaac agaaaattct ggacatccgg      480

aaaaatgtta aagatgctat cgtgacaatt gtttcagcaa tgagtactat aatacctcca      540

gttccgctgg ccaaccctga aaaccaattt cgatcagact acatcaagag catagcccct      600

atcactgact ttgaatattc ccaggaattc tttgaccatg tgaaaaaact ttgggacgat      660

gaaggcgtga aggcatgctt tgagagatcc aacgaatacc agctgattga ctgtgcacaa      720

tacttcctgg aaagaatcga cagcgtcagc ttggttgact acacacccac agaccaggac      780

ctcctcagat gcagagttct gacatctggg atttttgaga acgattccaa gtggacaaag      840

taaacttcca catgtttgat gttggtggcc agagggatga gaggagaaaa tggatccagt      900

gctttaacga tgtcacagct atcatttacg tcgcagcctg cagtagctac aacatggtga      960

ttcgagaaga taacaacacc aacaggctga gagagtccct ggatcttttt gaaagcatct     1020

ggaacaacag gtggttacgg accatttcta tcatcttgtt cttgaacaaa caagatatgc     1080

tggcagaaaa agtcttggca gggaaatcaa aaattgaaga ctatttccca gaatatgcaa     1140

attatactgt tcctgaagac gcaacaccag atgcaggaga agatcccaaa gttacaagag     1200

ccaagttctt tatccgggac ctgtttttga ggatcagcac ggccaccggt gacggcaaac     1260

attactgcta cccgcacttc acctgcgccg tggacacaga gaacatccgc agggtgttca     1320

acgactgccg cgacatcatc cagcggatgc acctcaagca gtatgagctc ttgtga         1376


<210>  50
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Leu Cys Tyr Ser Leu Arg Pro Leu Leu Phe Gly Gly Pro Gly 
1               5                   10                  15      


Asp Asp Pro Cys Ala Ala Ser Glu Pro Pro Val Glu Asp Ala Gln Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Leu Ala Pro Val Arg Ala Ala Ala Arg Asp Thr 
        35                  40                  45              


Ala Arg Thr Leu Leu Pro Arg Gly Gly Glu Gly Ser Pro Ala Cys Ala 
    50                  55                  60                  


Arg Pro Lys Ala Asp Lys Pro Lys Glu Lys Arg Gln Arg Thr Glu Gln 
65                  70                  75                  80  


Leu Ser Ala Glu Glu Arg Glu Ala Ala Lys Glu Arg Glu Ala Val Lys 
                85                  90                  95      


Glu Ala Arg Lys Val Ser Arg Gly Ile Asp Arg Met Leu Arg Asp Gln 
            100                 105                 110         


Lys Arg Asp Leu Gln Gln Thr His Arg Leu Leu Leu Leu Gly Ala Gly 
        115                 120                 125             


Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His Val 
    130                 135                 140                 


Asn Gly Phe Asn Pro Glu Glu Lys Lys Gln Lys Ile Leu Asp Ile Arg 
145                 150                 155                 160 


Lys Asn Val Lys Asp Ala Ile Val Thr Ile Val Ser Ala Met Ser Thr 
                165                 170                 175     


Ile Ile Pro Pro Val Pro Leu Ala Asn Pro Glu Asn Gln Phe Arg Ser 
            180                 185                 190         


Asp Tyr Ile Lys Ser Ile Ala Pro Ile Thr Asp Phe Glu Tyr Ser Gln 
        195                 200                 205             


Glu Phe Phe Asp His Val Lys Lys Leu Trp Asp Asp Glu Gly Val Lys 
    210                 215                 220                 


Ala Cys Phe Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
225                 230                 235                 240 


Tyr Phe Leu Glu Arg Ile Asp Ser Val Ser Leu Val Asp Tyr Thr Pro 
                245                 250                 255     


Thr Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
            260                 265                 270         


Glu Thr Arg Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
        275                 280                 285             


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
    290                 295                 300                 


Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser Tyr Asn Met Val 
305                 310                 315                 320 


Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu Ser Leu Asp Leu 
                325                 330                 335     


Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Ile Ile 
            340                 345                 350         


Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys Val Leu Ala Gly 
        355                 360                 365             


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala Asn Tyr Thr Val 
    370                 375                 380                 


Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro Lys Val Thr Arg 
385                 390                 395                 400 


Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile Ser Thr Ala Thr 
                405                 410                 415     


Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
            420                 425                 430         


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
        435                 440                 445             


Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
    450                 455             


<210>  51
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  51
atggcccggt cgctgacctg gcgctgctgc ccctggtgcc tgacggagga tgagaaggcc       60

gccgcccggg tggaccagga gatcaacagg atcctcttgg agcagaagaa gcaggaccgc      120

ggggagctga agctgctgct tttgggccca ggcgagagcg ggaagagcac cttcatcaag      180

cagatgcgga tcatccacgg cgccggctac tcggaggagg agcgcaaggg cttccggccc      240

ctggtctacc agaacatctt cgtgtccatg cgggccatga tcgaggccat ggagcggctg      300

cagattccat tcagcaggcc cgagagcaag caccacgcca gcctggtcat gagccaggac      360

ccctataaag tgaccacgtt tgagaagcgc tacgctgcgg ccatgcagtg gctgtggagg      420

gatgccggca tccgggcctg ctatgagcgt cggcgggaat tccacctgct cgattcagcc      480

gtgtactacc tgtcccacct ggagcgcatc accgaggagg gctacgtccc cacagctcag      540

gacgtgctcc gcagccgcat gcccaccact ggcatcaacg agtactgctt ctccgtgcag      600

aaaaccaacc tgcggatcgt ggacgtcggg ggccagaagt cagagcgtaa gaaatggatc      660

cattgtttcg agaacgtgat cgccctcatc tacctggcct cactgagtga atacgaccag      720

tgcctggagg agaacaacca ggagaaccgc atgaaggaga gcctcgcatt gtttgggact      780

atcctggaac taccctggtt caaaagcaca tccgtcatcc tctttctcaa caaaaccgac      840

atcctggagg agaaaatccc cacctcccac ctggctacct atttccccag tttccagggc      900

cctaagcagg atgctgaggc agccaagagg ttcatcctgg acatgtacac gaggatgtac      960

accgggtgcg tggacggccc cgagggcagc aagaagggcg cacgatcccg acgcctcttc     1020

agccactaca catgtgccac agacacacag aacatccgca aggtcttcaa ggacgtgcgg     1080

gactcggtgc tcgcccgcta cctggacgag atcaacctgc tgtga                     1125


<210>  52
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu 
1               5                   10                  15      


Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu 
            20                  25                  30          


Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu 
        35                  40                  45              


Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile 
    50                  55                  60                  


Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro 
65                  70                  75                  80  


Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala 
                85                  90                  95      


Met Glu Arg Leu Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His 
            100                 105                 110         


Ala Ser Leu Val Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Phe Glu 
        115                 120                 125             


Lys Arg Tyr Ala Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile 
    130                 135                 140                 


Arg Ala Cys Tyr Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala 
145                 150                 155                 160 


Val Tyr Tyr Leu Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val 
                165                 170                 175     


Pro Thr Ala Gln Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile 
            180                 185                 190         


Asn Glu Tyr Cys Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp 
        195                 200                 205             


Val Gly Gly Gln Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu 
    210                 215                 220                 


Asn Val Ile Ala Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln 
225                 230                 235                 240 


Cys Leu Glu Glu Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala 
                245                 250                 255     


Leu Phe Gly Thr Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr 
        275                 280                 285             


Ser His Leu Ala Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp 
    290                 295                 300                 


Ala Glu Ala Ala Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr 
305                 310                 315                 320 


Thr Gly Cys Val Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser 
                325                 330                 335     


Arg Arg Leu Phe Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile 
            340                 345                 350         


Arg Lys Val Phe Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu 
        355                 360                 365             


Asp Glu Ile Asn Leu Leu 
    370                 


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein motif

<400>  53

Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 
1               5                   10  


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein motif

<400>  54

Phe Ser Thr Cys Ser Ser His 
1               5           


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein motif

<400>  55

Pro Met Leu Asn Pro Phe Ile Tyr 
1               5               


