                         SEQUENCE LISTING

<110>  Universitt Zrich
       Universitt Bern
       Evax AG
       Fettelschoss, Antonia
       Fettelschoss, Victoria
       Bachmann, Martin
 
<120>  Treatment of Pruritus in Horses

<130>  P5273PC00

<150>  EP17159644.8
<151>  2017-03-07

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL-31 mature

<400>  1

Gly Pro Ile Tyr Gln Leu Gln Pro Lys Glu Ile Gln Ala Ile Ile Val 
1               5                   10                  15      


Glu Leu Gln Asn Leu Ser Lys Lys Leu Leu Asp Asp Tyr Leu Asn Lys 
            20                  25                  30          


Glu Lys Gly Val Gln Lys Phe Asp Ser Asp Leu Pro Ser Cys Phe Thr 
        35                  40                  45              


Ser Asp Ser Gln Ala Pro Gly Asn Ile Asn Ser Ser Ala Ile Leu Pro 
    50                  55                  60                  


Tyr Phe Lys Ala Ile Ser Pro Ser Leu Asn Asn Asp Lys Ser Leu Tyr 
65                  70                  75                  80  


Ile Ile Glu Gln Leu Asp Lys Leu Asn Phe Gln Asn Ala Pro Glu Thr 
                85                  90                  95      


Glu Val Ser Met Pro Thr Asp Asn Phe Glu Arg Lys Arg Phe Ile Leu 
            100                 105                 110         


Thr Ile Leu Arg Trp Phe Ser Asn Cys Leu Glu 
        115                 120             


<210>  2
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL-31-C-His

<400>  2

Gly Pro Ile Tyr Gln Leu Gln Pro Lys Glu Ile Gln Ala Ile Ile Val 
1               5                   10                  15      


Glu Leu Gln Asn Leu Ser Lys Lys Leu Leu Asp Asp Tyr Leu Asn Lys 
            20                  25                  30          


Glu Lys Gly Val Gln Lys Phe Asp Ser Asp Leu Pro Ser Cys Phe Thr 
        35                  40                  45              


Ser Asp Ser Gln Ala Pro Gly Asn Ile Asn Ser Ser Ala Ile Leu Pro 
    50                  55                  60                  


Tyr Phe Lys Ala Ile Ser Pro Ser Leu Asn Asn Asp Lys Ser Leu Tyr 
65                  70                  75                  80  


Ile Ile Glu Gln Leu Asp Lys Leu Asn Phe Gln Asn Ala Pro Glu Thr 
                85                  90                  95      


Glu Val Ser Met Pro Thr Asp Asn Phe Glu Arg Lys Arg Phe Ile Leu 
            100                 105                 110         


Thr Ile Leu Arg Trp Phe Ser Asn Cys Leu Glu Gly Gly Cys His His 
        115                 120                 125             


His His His His 
    130         


<210>  3
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL31 antigen var1

<400>  3

Gly Pro Ile Tyr Gln Leu Gln Pro Lys Glu Ile Gln Ala Ile Ile Val 
1               5                   10                  15      


Glu Leu Gln Asn Leu Ser Lys Lys Leu Leu Asp Asp Tyr Leu Asn Lys 
            20                  25                  30          


Glu Lys Gly Val Gln Lys Phe Asp Ser Asp Leu Pro Ser Cys Phe Thr 
        35                  40                  45              


Ser Asp Ser Gln Ala Pro Gly Asn Ile Asn Ser Ser Ala Ile Leu Pro 
    50                  55                  60                  


Tyr Phe Lys Ala Ile Ser Pro Ser Leu Asn Asn Asp Lys Ser Leu Tyr 
65                  70                  75                  80  


Ile Ile Glu Gln Leu Asp Lys Leu Asn Phe Gln Asn Ala Pro Glu Thr 
                85                  90                  95      


Glu Val Ser Met Pro Thr Asp Asn Phe Glu Arg Lys Arg Phe Ile Leu 
            100                 105                 110         


Thr Ile Leu Arg Trp Phe Ser Asn Cys Leu Glu His His His His His 
        115                 120                 125             


His Gly Gly Cys 
    130         


<210>  4
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL31 antigen var2

<400>  4

Gly Gly Cys Gly Pro Ile Tyr Gln Leu Gln Pro Lys Glu Ile Gln Ala 
1               5                   10                  15      


Ile Ile Val Glu Leu Gln Asn Leu Ser Lys Lys Leu Leu Asp Asp Tyr 
            20                  25                  30          


Leu Asn Lys Glu Lys Gly Val Gln Lys Phe Asp Ser Asp Leu Pro Ser 
        35                  40                  45              


Cys Phe Thr Ser Asp Ser Gln Ala Pro Gly Asn Ile Asn Ser Ser Ala 
    50                  55                  60                  


Ile Leu Pro Tyr Phe Lys Ala Ile Ser Pro Ser Leu Asn Asn Asp Lys 
65                  70                  75                  80  


Ser Leu Tyr Ile Ile Glu Gln Leu Asp Lys Leu Asn Phe Gln Asn Ala 
                85                  90                  95      


Pro Glu Thr Glu Val Ser Met Pro Thr Asp Asn Phe Glu Arg Lys Arg 
            100                 105                 110         


Phe Ile Leu Thr Ile Leu Arg Trp Phe Ser Asn Cys Leu Glu His His 
        115                 120                 125             


His His His His 
    130         


<210>  5
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL31 antigen var3

<400>  5

Gly Gly Cys Gly Pro Ile Tyr Gln Leu Gln Pro Lys Glu Ile Gln Ala 
1               5                   10                  15      


Ile Ile Val Glu Leu Gln Asn Leu Ser Lys Lys Leu Leu Asp Asp Tyr 
            20                  25                  30          


Leu Asn Lys Glu Lys Gly Val Gln Lys Phe Asp Ser Asp Leu Pro Ser 
        35                  40                  45              


Cys Phe Thr Ser Asp Ser Gln Ala Pro Gly Asn Ile Asn Ser Ser Ala 
    50                  55                  60                  


Ile Leu Pro Tyr Phe Lys Ala Ile Ser Pro Ser Leu Asn Asn Asp Lys 
65                  70                  75                  80  


Ser Leu Tyr Ile Ile Glu Gln Leu Asp Lys Leu Asn Phe Gln Asn Ala 
                85                  90                  95      


Pro Glu Thr Glu Val Ser Met Pro Thr Asp Asn Phe Glu Arg Lys Arg 
            100                 105                 110         


Phe Ile Leu Thr Ile Leu Arg Trp Phe Ser Asn Cys Leu Glu 
        115                 120                 125     


<210>  6
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL5 mature

<400>  6

Leu Ala Val Glu Ser Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu His Lys Asn His Gln Leu Cys Ile Glu Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Val Gln Gly Asp Ala 
    50                  55                  60                  


Val Ala Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Gly Tyr Ile Asp 
65                  70                  75                  80  


Leu Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Ile Glu Gly 
        115 


<210>  7
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL-5-C-His1

<400>  7

Ala Val Glu Ser Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr Leu 
1               5                   10                  15      


Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met Ile 
            20                  25                  30          


Pro Thr Pro Glu His Lys Asn His Gln Leu Cys Ile Glu Glu Val Phe 
        35                  40                  45              


Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Val Gln Gly Asp Ala Val 
    50                  55                  60                  


Ala Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Gly Tyr Ile Asp Leu 
65                  70                  75                  80  


Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Gln Phe Leu 
                85                  90                  95      


Asp Tyr Leu Gln Glu Phe Leu Gly Val Ile Asn Thr Glu Trp Thr Ile 
            100                 105                 110         


Glu Gly Gly Gly Cys Leu Glu His His His His His His His His 
        115                 120                 125         


<210>  8
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL-5-C-His2

<400>  8

Leu Ala Val Glu Ser Pro Met Asn Arg Leu Val Ala Glu Thr Leu Thr 
1               5                   10                  15      


Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly Asn Leu Met 
            20                  25                  30          


Ile Pro Thr Pro Glu His Lys Asn His Gln Leu Cys Ile Glu Glu Val 
        35                  40                  45              


Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Val Gln Gly Asp Ala 
    50                  55                  60                  


Val Ala Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Gly Tyr Ile Asp 
65                  70                  75                  80  


Leu Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val Lys Gln Phe 
                85                  90                  95      


Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Ile Asn Thr Glu Trp Thr 
            100                 105                 110         


Ile Glu Gly Gly Gly Cys His His His His His His 
        115                 120                 


<210>  9
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL5 antigen var1

<400>  9

Gly Gly Cys Leu Ala Val Glu Ser Pro Met Asn Arg Leu Val Ala Glu 
1               5                   10                  15      


Thr Leu Thr Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly 
            20                  25                  30          


Asn Leu Met Ile Pro Thr Pro Glu His Lys Asn His Gln Leu Cys Ile 
        35                  40                  45              


Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Val Gln 
    50                  55                  60                  


Gly Asp Ala Val Ala Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Gly 
65                  70                  75                  80  


Tyr Ile Asp Leu Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val 
                85                  90                  95      


Lys Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Ile Asn Thr 
            100                 105                 110         


Glu Trp Thr Ile Glu Gly His His His His His His 
        115                 120                 


<210>  10
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  eIL5 antigen var2

<400>  10

Gly Gly Cys Leu Ala Val Glu Ser Pro Met Asn Arg Leu Val Ala Glu 
1               5                   10                  15      


Thr Leu Thr Leu Leu Ser Thr His Arg Thr Leu Leu Ile Gly Asp Gly 
            20                  25                  30          


Asn Leu Met Ile Pro Thr Pro Glu His Lys Asn His Gln Leu Cys Ile 
        35                  40                  45              


Glu Glu Val Phe Gln Gly Ile Asp Thr Leu Lys Asn Gln Thr Val Gln 
    50                  55                  60                  


Gly Asp Ala Val Ala Lys Leu Phe Gln Asn Leu Ser Leu Ile Lys Gly 
65                  70                  75                  80  


Tyr Ile Asp Leu Gln Lys Lys Lys Cys Gly Gly Glu Arg Trp Arg Val 
                85                  90                  95      


Lys Gln Phe Leu Asp Tyr Leu Gln Glu Phe Leu Gly Val Ile Asn Thr 
            100                 105                 110         


Glu Trp Thr Ile Glu Gly 
        115             


<210>  11
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  forward primer eIL31

<400>  11
aacaaagaga agggagtgc                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  reverse primer eIL31

<400>  12
gctgagctgt tgatgttgc                                                    19


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  forward primer ebeta actin

<400>  13
ccagcacgat gaagatcaag                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  reverse primer ebeta actin

<400>  14
gtggacaatg aggccagaat                                                   20


<210>  15
<211>  218
<212>  PRT
<213>  cucumber mosaic virus

<400>  15

Met Asp Lys Ser Glu Ser Thr Ser Ala Gly Arg Ser Arg Arg Arg Arg 
1               5                   10                  15      


Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala Asp Ala Asn Phe 
            20                  25                  30          


Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys Thr Leu Ala Ala 
        35                  40                  45              


Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly Ser Glu Arg Cys 
    50                  55                  60                  


Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys Pro Pro Lys Ile 
65                  70                  75                  80  


Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp Ser Val 
                85                  90                  95      


Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg Val Asn 
            100                 105                 110         


Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg Lys Val 
        115                 120                 125             


Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met Phe Ala 
    130                 135                 140                 


Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser Gly Val 
145                 150                 155                 160 


Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg Ala Asp 
                165                 170                 175     


Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys Asp Asp 
            180                 185                 190         


Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp Val Glu His Gln 
        195                 200                 205             


Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215             


<210>  16
<211>  217
<212>  PRT
<213>  cucumber mosaic virus

<400>  16

Asp Lys Ser Glu Ser Thr Ser Ala Gly Arg Asn Arg Arg Arg Arg Pro 
1               5                   10                  15      


Arg Arg Gly Ser Arg Ser Ala Ser Ser Ser Ala Asp Ala Asn Phe Arg 
            20                  25                  30          


Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys Thr Leu Ala Ala Gly 
        35                  40                  45              


Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly Ser Glu Arg Cys Lys 
    50                  55                  60                  


Pro Gly Tyr Thr Phe Ser Ser Ile Thr Leu Lys Pro Pro Lys Ile Asp 
65                  70                  75                  80  


Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp Ser Val Thr 
                85                  90                  95      


Glu Phe Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg Val Asn Pro 
            100                 105                 110         


Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg Lys Val Pro 
        115                 120                 125             


Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met Phe Ala Asp 
    130                 135                 140                 


Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser Gly Val Gln 
145                 150                 155                 160 


Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg Ala Asp Ile 
                165                 170                 175     


Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys Asp Asp Ala 
            180                 185                 190         


Leu Glu Thr Asp Glu Leu Val Leu His Val Asp Ile Glu His Gln Arg 
        195                 200                 205             


Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215         


<210>  17
<211>  218
<212>  PRT
<213>  cucumber mosaic virus

<400>  17

Met Asp Lys Ser Glu Ser Pro Asn Ala Ser Arg Thr Ser Arg Arg Arg 
1               5                   10                  15      


Arg Pro Arg Arg Gly Ser Arg Ser Ala Ser Gly Ala Asp Ala Gly Leu 
            20                  25                  30          


Arg Ala Leu Thr Gln Gln Met Leu Lys Leu Asn Lys Thr Leu Ala Ile 
        35                  40                  45              


Gly Arg Pro Thr Leu Asn His Pro Thr Phe Val Gly Ser Ala Ser Cys 
    50                  55                  60                  


Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys Pro Pro Glu Ile 
65                  70                  75                  80  


Glu Lys Gly Ser Tyr Phe Gly Arg Arg Leu Ser Leu Pro Asp Ser Val 
                85                  90                  95      


Thr Asp Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg Ile Asn 
            100                 105                 110         


Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg Lys Val 
        115                 120                 125             


Pro Ser Ser Ser Asp Leu Ser Val Ala Thr Ile Ser Ala Met Phe Gly 
    130                 135                 140                 


Asp Gly Asn Ser Pro Val Leu Val Tyr Gln Tyr Thr Ala Ser Gly Val 
145                 150                 155                 160 


Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Glu Met Arg Ala Asp 
                165                 170                 175     


Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys Asp Asp 
            180                 185                 190         


Lys Leu Glu Glu Asp Glu Ile Val Leu His Val Asp Val Glu His Gln 
        195                 200                 205             


Arg Ile Pro Ile Ser Arg Met Leu Pro Thr 
    210                 215             


<210>  18
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  tetanus toxoid epitope tt830

<400>  18

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  


<210>  19
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  PADRE

<400>  19

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  20
<211>  222
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Ntt830

<400>  20

Met Gly Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Arg Arg Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25                  30          


Asp Ala Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys 
        35                  40                  45              


Thr Leu Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly 
    50                  55                  60                  


Ser Glu Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys 
65                  70                  75                  80  


Pro Pro Lys Ile Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu 
                85                  90                  95      


Pro Asp Ser Val Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln 
            100                 105                 110         


Ile Arg Val Asn Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr 
        115                 120                 125             


Val Arg Lys Val Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser 
    130                 135                 140                 


Ala Met Phe Ala Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala 
145                 150                 155                 160 


Ala Ser Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala 
                165                 170                 175     


Met Arg Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr 
            180                 185                 190         


Ser Lys Asp Asp Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp 
        195                 200                 205             


Val Glu His Gln Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215                 220         


<210>  21
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  CMV-Npadr

<400>  21

Met Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Arg Arg 
1               5                   10                  15      


Arg Arg Pro Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala Asp Ala 
            20                  25                  30          


Asn Phe Arg Val Leu Ser Gln Gln Leu Ser Arg Leu Asn Lys Thr Leu 
        35                  40                  45              


Ala Ala Gly Arg Pro Thr Ile Asn His Pro Thr Phe Val Gly Ser Glu 
    50                  55                  60                  


Arg Cys Lys Pro Gly Tyr Thr Phe Thr Ser Ile Thr Leu Lys Pro Pro 
65                  70                  75                  80  


Lys Ile Asp Arg Gly Ser Tyr Tyr Gly Lys Arg Leu Leu Leu Pro Asp 
                85                  90                  95      


Ser Val Thr Glu Tyr Asp Lys Lys Leu Val Ser Arg Ile Gln Ile Arg 
            100                 105                 110         


Val Asn Pro Leu Pro Lys Phe Asp Ser Thr Val Trp Val Thr Val Arg 
        115                 120                 125             


Lys Val Pro Ala Ser Ser Asp Leu Ser Val Ala Ala Ile Ser Ala Met 
    130                 135                 140                 


Phe Ala Asp Gly Ala Ser Pro Val Leu Val Tyr Gln Tyr Ala Ala Ser 
145                 150                 155                 160 


Gly Val Gln Ala Asn Asn Lys Leu Leu Tyr Asp Leu Ser Ala Met Arg 
                165                 170                 175     


Ala Asp Ile Gly Asp Met Arg Lys Tyr Ala Val Leu Val Tyr Ser Lys 
            180                 185                 190         


Asp Asp Ala Leu Glu Thr Asp Glu Leu Val Leu His Val Asp Val Glu 
        195                 200                 205             


His Gln Arg Ile Pro Thr Ser Gly Val Leu Pro Val 
    210                 215                 220 


<210>  22
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  pET42b-eIL-31

<400>  22
catatgggtc cgatttatca gctgcagccg aaagaaattc aggccattat tgttgaactg       60

cagaacctga gcaaaaaact gctggatgat tacctgaaca aagaaaaagg cgtgcagaaa      120

tttgatagcg atctgccgag ctgttttacc agcgatagcc aggcaccggg taacattaat      180

agcagcgcaa ttctgccgta tttcaaagca attagcccga gcctgaataa tgataaaagc      240

ctgtatatta tcgaacagct ggataaactg aactttcaga atgcaccgga aaccgaagtt      300

agcatgccga ccgataattt tgaacgcaaa cgttttattc tgaccatcct gcgttggttt      360

agcaattgtc tggaaggtgg tggttgtctc gagcaccacc accaccacca ccaccactaa      420


<210>  23
<211>  390
<212>  DNA
<213>  artificial sequence

<220>
<223>  pET42b-eIL-5

<400>  23
catatggcag ttgaaagccc gatgaatcgt ctggttgcag aaaccctgac cctgctgagc       60

acccatcgta cactgctgat tggtgatggt aatctgatga ttccgacacc ggaacataaa      120

aatcatcagc tgtgtatcga agaagtgttt cagggcattg ataccctgaa aaatcagacc      180

gttcagggtg atgcagttgc aaaactgttt cagaatctga gcctgatcaa aggctatatc      240

gatctgcaga aaaaaaaatg cggtggtgaa cgttggcgtg ttaaacagtt tctggattat      300

ctgcaagaat ttctgggcgt gattaatacc gaatggacca ttgaaggtgg tggttgtctc      360

gagcaccacc accaccacca ccaccactaa                                       390


<210>  24
<211>  132
<212>  PRT
<213>  Bacteriophage Q-beta

<400>  24

Ala Lys Leu Glu Thr Val Thr Leu Gly Asn Ile Gly Lys Asp Gly Lys 
1               5                   10                  15      


Gln Thr Leu Val Leu Asn Pro Arg Gly Val Asn Pro Thr Asn Gly Val 
            20                  25                  30          


Ala Ser Leu Ser Gln Ala Gly Ala Val Pro Ala Leu Glu Lys Arg Val 
        35                  40                  45              


Thr Val Ser Val Ser Gln Pro Ser Arg Asn Arg Lys Asn Tyr Lys Val 
    50                  55                  60                  


Gln Val Lys Ile Gln Asn Pro Thr Ala Cys Thr Ala Asn Gly Ser Cys 
65                  70                  75                  80  


Asp Pro Ser Val Thr Arg Gln Ala Tyr Ala Asp Val Thr Phe Ser Phe 
                85                  90                  95      


Thr Gln Tyr Ser Thr Asp Glu Glu Arg Ala Phe Val Arg Thr Glu Leu 
            100                 105                 110         


Ala Ala Leu Leu Ala Ser Pro Leu Leu Ile Asp Ala Ile Asp Gln Leu 
        115                 120                 125             


Asn Pro Ala Tyr 
    130         


<210>  25
<211>  329
<212>  PRT
<213>  Bacteriophage Q-beta

<400>  25

Met Ala Lys Leu Glu Thr Val Thr Leu Gly Asn Ile Gly Lys Asp Gly 
1               5                   10                  15      


Lys Gln Thr Leu Val Leu Asn Pro Arg Gly Val Asn Pro Thr Asn Gly 
            20                  25                  30          


Val Ala Ser Leu Ser Gln Ala Gly Ala Val Pro Ala Leu Glu Lys Arg 
        35                  40                  45              


Val Thr Val Ser Val Ser Gln Pro Ser Arg Asn Arg Lys Asn Tyr Lys 
    50                  55                  60                  


Val Gln Val Lys Ile Gln Asn Pro Thr Ala Cys Thr Ala Asn Gly Ser 
65                  70                  75                  80  


Cys Asp Pro Ser Val Thr Arg Gln Ala Tyr Ala Asp Val Thr Phe Ser 
                85                  90                  95      


Phe Thr Gln Tyr Ser Thr Asp Glu Glu Arg Ala Phe Val Arg Thr Glu 
            100                 105                 110         


Leu Ala Ala Leu Leu Ala Ser Pro Leu Leu Ile Asp Ala Ile Asp Gln 
        115                 120                 125             


Leu Asn Pro Ala Tyr Trp Thr Leu Leu Ile Ala Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser Lys Pro Asp Pro Val Ile Pro Asp Pro Pro Ile Asp Pro Pro Pro 
145                 150                 155                 160 


Gly Thr Gly Lys Tyr Thr Cys Pro Phe Ala Ile Trp Ser Leu Glu Glu 
                165                 170                 175     


Val Tyr Glu Pro Pro Thr Lys Asn Arg Pro Trp Pro Ile Tyr Asn Ala 
            180                 185                 190         


Val Glu Leu Gln Pro Arg Glu Phe Asp Val Ala Leu Lys Asp Leu Leu 
        195                 200                 205             


Gly Asn Thr Lys Trp Arg Asp Trp Asp Ser Arg Leu Ser Tyr Thr Thr 
    210                 215                 220                 


Phe Arg Gly Cys Arg Gly Asn Gly Tyr Ile Asp Leu Asp Ala Thr Tyr 
225                 230                 235                 240 


Leu Ala Thr Asp Gln Ala Met Arg Asp Gln Lys Tyr Asp Ile Arg Glu 
                245                 250                 255     


Gly Lys Lys Pro Gly Ala Phe Gly Asn Ile Glu Arg Phe Ile Tyr Leu 
            260                 265                 270         


Lys Ser Ile Asn Ala Tyr Cys Ser Leu Ser Asp Ile Ala Ala Tyr His 
        275                 280                 285             


Ala Asp Gly Val Ile Val Gly Phe Trp Arg Asp Pro Ser Ser Gly Gly 
    290                 295                 300                 


Ala Ile Pro Phe Asp Phe Thr Lys Phe Asp Lys Thr Lys Cys Pro Ile 
305                 310                 315                 320 


Gln Ala Val Ile Val Val Pro Arg Ala 
                325                 


<210>  26
<211>  131
<212>  PRT
<213>  Bacteriophage AP205

<400>  26

Met Ala Asn Lys Pro Met Gln Pro Ile Thr Ser Thr Ala Asn Lys Ile 
1               5                   10                  15      


Val Trp Ser Asp Pro Thr Arg Leu Ser Thr Thr Phe Ser Ala Ser Leu 
            20                  25                  30          


Leu Arg Gln Arg Val Lys Val Gly Ile Ala Glu Leu Asn Asn Val Ser 
        35                  40                  45              


Gly Gln Tyr Val Ser Val Tyr Lys Arg Pro Ala Pro Lys Pro Glu Gly 
    50                  55                  60                  


Cys Ala Asp Ala Cys Val Ile Met Pro Asn Glu Asn Gln Ser Ile Arg 
65                  70                  75                  80  


Thr Val Ile Ser Gly Ser Ala Glu Asn Leu Ala Thr Leu Lys Ala Glu 
                85                  90                  95      


Trp Glu Thr His Lys Arg Asn Val Asp Thr Leu Phe Ala Ser Gly Asn 
            100                 105                 110         


Ala Gly Leu Gly Phe Leu Asp Pro Thr Ala Ala Ile Val Ser Ser Asp 
        115                 120                 125             


Thr Thr Ala 
    130     


<210>  27
<211>  27
<212>  PRT
<213>  artificial sequence

<220>
<223>  aa 2-28 of SEQ ID NO:24

<400>  27

Asp Lys Ser Glu Ser Thr Ser Ala Gly Arg Ser Arg Arg Arg Arg Pro 
1               5                   10                  15      


Arg Arg Gly Ser Arg Ser Ala Pro Ser Ser Ala 
            20                  25          


<210>  28
<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  mIL31 mature

<400>  28

Thr Cys Ser Leu Ser Phe Gly Ala Pro Ile Ser Lys Glu Asp Leu Arg 
1               5                   10                  15      


Thr Thr Ile Asp Leu Leu Lys Gln Glu Ser Gln Asp Leu Tyr Asn Asn 
            20                  25                  30          


Tyr Ser Ile Lys Gln Ala Ser Gly Met Ser Ala Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Pro Cys Phe Ser Leu Asp Arg Glu Ala Leu Thr Asn Ile Ser Val 
    50                  55                  60                  


Ile Ile Ala His Leu Glu Lys Val Lys Val Leu Ser Glu Asn Thr Val 
65                  70                  75                  80  


Asp Thr Ser Trp Val Ile Arg Trp Leu Thr Asn Ile Ser Cys Phe Asn 
                85                  90                  95      


Pro Leu Asn Leu Asn Ile Ser Val Pro Gly Asn Thr Asp Glu Ser Tyr 
            100                 105                 110         


Asp Cys Lys Val Phe Val Leu Thr Val Leu Lys Gln Phe Ser Asn Cys 
        115                 120                 125             


Met Ala Glu Leu Gln Ala Lys Asp Asn Thr Thr Cys 
    130                 135                 140 


<210>  29
<211>  150
<212>  PRT
<213>  artificial sequence

<220>
<223>  mIL-31-C-His

<400>  29

Thr Cys Ser Leu Ser Phe Gly Ala Pro Ile Ser Lys Glu Asp Leu Arg 
1               5                   10                  15      


Thr Thr Ile Asp Leu Leu Lys Gln Glu Ser Gln Asp Leu Tyr Asn Asn 
            20                  25                  30          


Tyr Ser Ile Lys Gln Ala Ser Gly Met Ser Ala Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Pro Cys Phe Ser Leu Asp Arg Glu Ala Leu Thr Asn Ile Ser Val 
    50                  55                  60                  


Ile Ile Ala His Leu Glu Lys Val Lys Val Leu Ser Glu Asn Thr Val 
65                  70                  75                  80  


Asp Thr Ser Trp Val Ile Arg Trp Leu Thr Asn Ile Ser Cys Phe Asn 
                85                  90                  95      


Pro Leu Asn Leu Asn Ile Ser Val Pro Gly Asn Thr Asp Glu Ser Tyr 
            100                 105                 110         


Asp Cys Lys Val Phe Val Leu Thr Val Leu Lys Gln Phe Ser Asn Cys 
        115                 120                 125             


Met Ala Glu Leu Gln Ala Lys Asp Asn Thr Thr Cys Gly Gly Gly Cys 
    130                 135                 140                 


His His His His His His 
145                 150 


<210>  30
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  forward primer

<400>  30
ggctgtattc ccctccatcg                                                   20


<210>  31
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  reverse primer

<400>  31
ccagttggta acaatgccat gt                                                22


