                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Method for discovery of alternative antigen specific antibody 
       variants

<130>  P34157-WO

<150>  EP17159617.4
<151>  2017-03-07

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1

Asp His Asp Thr Gly Ser His Pro Tyr Asn Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Asp His Asp Thr Gly Ser Ser Pro Tyr Asn Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Asp His Asp Thr Gly Ser Ser Gln Tyr Asn Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Asp His Asp Thr Gly Ser Asn Pro Tyr Asn Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Asp His Asp Thr Gly Ser Ser Pro Tyr Asn Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Asp His Asp Thr Gly Ser His Pro Tyr Lys Tyr Ala Asn Met Asp Val 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Glu His Asp Thr Gly Ser His Pro Tyr Cys Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Asp His Asp Thr Gly Asn His Pro Tyr Asn Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Tyr Val 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Phe 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Asp His Glu Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  13

Glu His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  14

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  15

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Ile Asp Val 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  16

Asp Asn Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

Asp His Asp Asn Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  18

Asp His Asp Thr Gly Ser His Pro Tyr Ser His Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  19

Asp His Asp Thr Gly Cys His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  20

Asp His Asp Thr Gly Asn His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  21

Asp His Asp Thr Gly Ser His Pro Tyr Ser Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  22

Asp Tyr Asp Thr Gly Ser His Pro Tyr Asn Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Asp His Asp Thr Gly Ser His Pro Tyr Asn Tyr Glu Asn Leu Asp Val 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Asp His Asp Thr Gly Ser His Pro Tyr Asn Tyr Glu Asn Arg Asp Val 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Asp His Asp Thr Gly Ser His Pro Tyr Asn Asn Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Asp His Asp Thr Gly Ser His Pro Tyr Asn Tyr Glu Asn Met Asp Val 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Asp His Asp Thr Gly Ser Ser Pro Asp Asn Tyr Asp Asn Met Glu Val 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Asp His Asp Ala Gly Ser Ser Pro Tyr Asn Tyr Asp Asn Met Asp Val 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  29

Asp Ser Leu Ser Tyr Gly Tyr Ala Tyr Ala Thr Asn Tyr Phe Asn Ile 
1               5                   10                  15      


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbHC.up

<400>  30
aagcttgcca ccatggagac tgggctgcgc tggcttc                                37


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbHC.do

<400>  31
ccattggtga gggtgcccga g                                                 21


<210>  32
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbLC.up

<400>  32
aagcttgcca ccatggacay gagggccccc actc                                   34


<210>  33
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbLC.do

<400>  33
cagagtrctg ctgaggttgt aggtac                                            26


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbHCfinal_FS.up

<400>  34
atggagactg ggctgcgctg gcttc                                             25


<210>  35
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rbHC_shortCH1_fs2.do

<400>  35
gggaagactg atggagc                                                      17


<210>  36
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  36

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  37
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  37

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  38
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  38

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ala Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  39

Cys Pro Pro Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Pro Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  40

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Asp Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  41
<211>  110
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  41

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Pro Asn Ile Leu Gly Asn 
            20                  25                  30          


Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Val Tyr Arg Ser Asp 
                85                  90                  95      


Ser Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  42
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  42

Cys Gln Leu Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Lys Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Pro Glu Asp Thr Ala Thr Tyr Val Cys Gly Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  43
<211>  115
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  43

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Lys Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Ser 
                85                  90                  95      


Gly Gly Gly Gly Asn Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  44
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  44

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Ser 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Cys Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ala Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  45
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  45

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  46
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  46

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  47
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  47

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  48

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  49
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  49

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  50
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  50

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  51
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  51

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  52
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  52

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  53
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  53

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Phe Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  54
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  54

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Ser 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  55
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  55

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Gly Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Asn Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  56
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  56

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  57
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  57

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Thr Ser Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  58
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  58

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ser Leu Lys Met 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  59
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  59

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Phe 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Pro Gly Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Ser Phe Asp Ser Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ala Ser 
        115     


<210>  60
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  60

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Ile Phe Asp Ser Asn Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Tyr Ala Cys Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  61
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  61

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Ala Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Ile Phe Asp Ser Asn Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Tyr Ala Ser Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  62
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  62

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Ile Phe Asp Ser Asn Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Tyr Ala Ser Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  63
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  63

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Ile Phe Asp Ser Asn Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Trp Thr Tyr Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  64
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  64

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Ile Phe Asp Ser Asn Arg Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Pro Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Tyr Ala Ser Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  65
<211>  113
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  65

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Val Val Ser Trp Val Arg Gln Val Pro Gly Glu Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Leu Val Phe Asp Thr Asn Thr Phe Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Val Asp Leu Thr Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Gly 
                85                  90                  95      


Gly Tyr Ala Ser Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  66
<211>  116
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  66

Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Arg Ser 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Phe Ile Gly Ser Ser Gly Thr Thr Tyr Cys Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Ala Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser Arg 
                85                  90                  95      


Asn Tyr Asp Asp Tyr Thr Phe Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  67
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  67

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  68
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  68

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Pro Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  69

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  70

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  71
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  71

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Thr Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  72
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  72

Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Arg Pro Thr Thr Glu Asp Thr Ala Thr Tyr Ile Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  73

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  74

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  75

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ala Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  76
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  76

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Glu Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  77
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  77

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  78
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  78

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Ala Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  79
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  79

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asp Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  120
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  80

Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Trp Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Asn Asp 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Phe Tyr Val Ala Thr Glu Ile Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg 
                85                  90                  95      


Asp Gly Gly Tyr Thr Gly Asp Gly Tyr Ala Phe Glu Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


