                         SEQUENCE LISTING

<110>  Bayer CropScience AG/Bayer CropScience LP
 
<120>  HPPD VARIANTS AND METHODS OF USE

<130>  BCS171005

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  358
<212>  PRT
<213>  Pseudomonas fluorescens


<220>
<221>  4-hydroxyphenylpyruvate dioxygenase (HPPD; Pseudomonas 
       fluorescens)
<222>  (1)..(358)

<400>  1

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  2
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  2

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Ala Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  3
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  3

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  4
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  4

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  5
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  5

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  6
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  6

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  7
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  7

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  8
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  8

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  9
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  9

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  10
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  10

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  11
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  11

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  12
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  12

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  13
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  13

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  14
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  14

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  15
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  15

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  16
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  16

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  17
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  17

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  18
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  18

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  19
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  19

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  20
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  20

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  21
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  21

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  22
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  22

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  23
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  23

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  24
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  24

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  25
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  25

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  26
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  26

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  27
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  27

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  28
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  28

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  29
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  29

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  30
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  30

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  31
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  31

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  32
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  32

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  33
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  33

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  34
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  34

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  35
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  35

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  36
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  36

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  37
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  37

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  38
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  38

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  39
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  39

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  40
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  40

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  41
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  41

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Arg Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  42
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  42

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  43
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  43

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  44
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  44

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Glu Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  45
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  45

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  46
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  46

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  47
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  47

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  48
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  48

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Gly Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  49
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  49

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  50
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  50

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ser Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  51
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  51

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  52
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  52

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  53
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  53

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Val Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  54
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  54

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  55
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  55

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  56
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  56

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  57
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  57

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Asn Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  58
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  58

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  59
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  59

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  60
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  60

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Ile Asp Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Asp 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Lys Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  61
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  61

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  62
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  62

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  63
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  63

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Ala Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  64
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  64

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  65
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  65

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Ser Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  66
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  66

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  67
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  67

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  68
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  68

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Gln Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  69
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  69

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Arg Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  70
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  70

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Lys Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Ala Asp Ser Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Gln Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro His 
                325                 330                 335     


Ser Phe Lys Val Leu Phe Glu Gln Met Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  71
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant HPPD polypeptide

<400>  71

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Leu Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Phe 
                325                 330                 335     


Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  72
<211>  1074
<212>  DNA
<213>  Pseudomonas fluorescens

<220>
<221>  CDS 4-hydroxyphenylpyruvate dioxygenase (HPPD)
<222>  (1)..(1074)


<400>  72
atggcagatc tatacgaaaa cccaatgggc ctgatgggct ttgaattcat cgaattcgcg       60

tcgccgacgc cgggtaccct ggagccgatc ttcgagatca tgggcttcac caaagtcgcg      120

acccaccgtt ccaagaacgt gcacctgtac cgccagggcg agatcaacct gatcctcaac      180

aacgagccca acagcatcgc ctcctacttt gcggccgaac acggcccgtc ggtgtgcggc      240

atggcgttcc gcgtgaagga ctcgcaaaag gcctacaacc gcgccctgga actcggcgcc      300

cagccgatcc atattgacac cgggccgatg gaattgaacc tgccggcgat caagggcatc      360

ggcggcgcgc cgttgtacct gatcgaccgt ttcggcgaag gcagctcgat ctacgacatc      420

gacttcgtgt acctcgaagg tgtggagcgc aatccggtcg gtgcaggtct caaagtcatc      480

gaccacctga cccacaacgt ctatcgcggc cgcatggtct actgggccaa cttctacgag      540

aaattgttca acttccgtga agcgcgttac ttcgatatca agggcgagta caccggcctg      600

acttccaagg ccatgagtgc gccggacggc atgatccgca tcccgctgaa cgaagagtcg      660

tccaagggcg cggggcagat cgaagagttc ctgatgcagt tcaacggcga aggcatccag      720

cacgtggcgt tcctcaccga cgacctggtc aagacctggg acgcgttgaa gaaaatcggc      780

atgcgcttca tgaccgcgcc gccagacact tattacgaaa tgctcgaagg ccgcctgcct      840

gaccacggcg agccggtgga tcaactgcag gcacgcggta tcctgctgga cggatcttcc      900

gtggaaggcg acaaacgcct gctgctgcag atcttctcgg aaaccctgat gggcccggtg      960

ttcttcgaat tcatccagcg caagggcgac gatgggtttg gcgagggtaa cttcaaggcg     1020

ctgttcgagt ccatcgaacg tgaccaggtg cgtcgtggtg tattgaccgc cgat           1074


