                         SEQUENCE LISTING

<110>  F1 Oncology, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TRANSDUCING AND EXPANDING 
       LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF

<130>  F1.001.WO.03

<150>  62/467,039
<151>  2017-03-03

<150>  PCT/US2017/023112
<151>  2017-03-19

<150>  62/560,176
<151>  2017-09-18

<150>  62/564,253
<151>  2017-09-27

<150>  62/564,991
<151>  2017-09-28

<150>  15/462,855
<151>  2017-03-19

<150>  15/644,778
<151>  2017-07-08

<150>  PCT/US2017/041277
<151>  2017-07-08

<160>  521   

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  3
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  4
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  5
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  6
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  6

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  7
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  8
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  9
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  9

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  10
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  11
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  12
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  13
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  15
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  17
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  18
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  19
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  20
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Met Ser 
        115                 120                 125             


Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu 
    130                 135                 140                 


Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro 
145                 150                 155                 160 


Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys 
                165                 170                 175     


Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys 
            180                 185                 190         


Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205     


<210>  21
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  21

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  22
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  23
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  24
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  25
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  26
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  27
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
            100                 105         


<210>  29
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  30
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  31
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  32
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  33
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  34
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  35
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  36
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic HA Epitope

<400>  37

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic FLAG Epitope

<400>  38

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic c-myc Epitope

<400>  39

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic His5 Affinity

<400>  40

His His His His His 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic HisX6 Affinity

<400>  41

His His His His His His 
1               5       


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Strep Tag Affinity

<400>  42

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  43
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic HisX6 Affinity

<400>  43

Arg Tyr Ile Arg Ser 
1               5   


<210>  44
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Affinity

<400>  44

Phe His His Thr 
1               


<210>  45
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Affinity

<400>  45

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  46
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  47
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  48
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  49
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  50
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  50

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  51
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  51

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  52
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  52

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 1

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  54
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 2

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 3

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  


<210>  56
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 4

<400>  56

Gly Gly Ser Gly 
1               


<210>  57
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 5

<400>  57

Gly Gly Ser Gly Gly 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 6

<400>  58

Gly Ser Gly Ser Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 7

<400>  59

Gly Ser Gly Gly Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 8

<400>  60

Gly Gly Gly Ser Gly 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Linker 9

<400>  61

Gly Ser Ser Ser Gly 
1               5   


<210>  62
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 1

<400>  62

Cys Pro Pro Cys 
1               


<210>  63
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 2

<400>  63

Asp Lys Thr His Thr 
1               5   


<210>  64
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 3

<400>  64

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 4

<400>  65

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  66
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 5

<400>  66

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 6

<400>  67

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 7

<400>  68

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  69
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 8

<400>  69

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  70
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 9

<400>  70

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  71
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 10

<400>  71

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  72
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 11

<400>  72

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  73
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hinge 12

<400>  73

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  74
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  75
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  75

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  76
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  76

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  77
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic 2A-1 Cleavage signal

<400>  77

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  78
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  79
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  79

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  80
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  80

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  81
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  81

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  82
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser 
                245                 250                 255     


Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile 
            260                 265                 270         


Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu 
        275                 280                 285             


His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro 
    290                 295                 300                 


Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala 
305                 310                 315                 320 


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
                325                 330                 335     


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
            340                 345                 350         


Cys Pro Ser Glu Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp 
        355                 360                 365             


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
    370                 375                 380                 


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
385                 390                 395                 400 


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
                405                 410                 415     


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
            420                 425                 430         


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
        435                 440                 445             


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 460             


<210>  83
<211>  13673
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Dox-rapamycin inducible lentiviral genome with 
       riboswitch

<400>  83
gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga acatgaaata       60

acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa tcatgcgtca      120

ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat tgacaagcac      180

gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga cggattcgcg      240

ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac gcagactatc      300

tttctagggt taagacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca      360

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc      420

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc      480

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat      540

acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt      600

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      660

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      720

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      780

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      840

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      900

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      960

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt     1020

ttgttttgga accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg     1080

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctccctatc     1140

agtgatagag atctccctat cagtgataga gatcgtcgac gagctcgttt agtgaaccgt     1200

cagatcgcct ggagacgccc tcgaagccgc ggtgcgggtg ccagggcgtg ccctgggtct     1260

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt     1320

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac     1380

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1440

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1500

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1560

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1620

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1680

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1740

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1800

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1860

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1920

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1980

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     2040

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     2100

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     2160

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     2220

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     2280

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     2340

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     2400

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2460

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2520

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2580

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2640

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2700

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2760

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc tcgacggtat     2820

cgattagact gtagcccagg aatatggcag ctagattgta cacatttaga aggaaaagtt     2880

atcttggtag cagttcatgt agccagtgga tatatagaag cagaagtaat tccagcagag     2940

acagggcaag aaacagcata cttcctctta aaattagcag gaagatggcc agtaaaaaca     3000

gtacatacag acaatggcag caatttcacc agtactacag ttaaggccgc ctgttggtgg     3060

gcggggatca agcaggaatt tggcattccc tacaatcccc aaagtcaagg agtaatagaa     3120

tctatgaata aagaattaaa gaaaattata ggacaggtaa gagatcaggc tgaacatctt     3180

aagacagcag tacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg     3240

gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa     3300

ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat     3360

ccagtttggc tgcattgatc acgtgagggg ctctagactc tagacacaca aaaaaccaac     3420

acacagatct aatgaaaata aagatctttt attgagaaac ttatacaggg tagcataatg     3480

ggctactgac cccgccttca aacctatttg gagactataa gtgaaaatta tcactggttt     3540

tggtagaagc tggacatggt gacatatgct tcttcttgat ttgatcccag ggaagtaaga     3600

atgggctgac cctgagcaac tgggttcaat gtcaggattc cagattggag agaaaatgga     3660

gggggcagcg tgctgtttgt agtcccaagg ctaagcagga ggtcctggta cacatgaggc     3720

ccattcttgc cactctccct gcagtctagg gacctggaag aggagagaat aggggcgtca     3780

catgcactga cattcccagc caggcatgtg agggatgaat ctcttccaaa gctttctgga     3840

gtgacgacta catcctcaga tgggcagttg gggctctgca catcccctcc aagcctctgc     3900

ttctcagatt cttctagttg ctgaggaaac gtatcttgca gaaaaccttc cacttcatct     3960

ctagcttgaa tgtcatccac cctatgaatc tggcagtcca ggaaactttc aggattgaaa     4020

ctcacattta aattttttct tggtttctta caaagatgtt ccagagtctt cttatgatcg     4080

gggagactgg gccatacgat aggcttaatc ctttttttcc ataacacaca ggccaagatg     4140

accaacagag cgacagagaa aaaactcaaa atgctgatgg tcaggcatgg tggtagtaag     4200

ataggatcca tctcccctga gctattattg atctctggag ttctgaagta ataacttgga     4260

ctccattcac tccagaagcc tttaaaatag tgatcaggga tggatcgaac tttaatctca     4320

tacattgctg ccggttggag ctttctctgc aggagtgtca gctttgtgct ggataaattc     4380

acatgcgtcc atttgttttc atccttttcc tggcggtaag ctacatcatg cattaaaact     4440

tttacatact tcttttgcaa gtgtgatgta ttaaatgtca ccacaaagtc attggctcct     4500

tcccgataga tgacactcag gtcaaaagga gcctcaggtt taactatagt ggttaggtct     4560

atttttttgc aggttagact cttttctcca accttcacac atatattgct ctttccaatc     4620

agtaagaatt tctttgtctc gatgaaatat atctcttgta gtttcctgaa attcaggcac     4680

tttacctcca cgagggcccc acatatttca aattccagat tggtggtgtt gacatctggg     4740

tcctcaaaag cacatgtcag tgaatgctgc gatccattca cttccaactg gctatagcat     4800

gagaatgagt agtcatccag ttctgcatct tccaagtctc cattttgagc atagccactt     4860

tctccagaaa cgacttgaag taaagaaaaa accatgccaa aagttgtacc tagaattgtc     4920

attgggccgg gattttcctc cacgtccccg catgttagta gacttcccct gccctcgccg     4980

gagcgagggg gcagggcctg catgtgaagg gcgtcgtagg tgtccttggt ggctgtactg     5040

agaccctggt aaaggccatc gtgccccttg cccctccggc gctcgccttt catcccaatc     5100

tcactgtagg cctccgccat cttatctttc tgcagttcat tgtacaggcc ttcctgaggg     5160

ttcttccttc tcggctttcc ccccatctca gggtcccggc cacgtctctt gtccaaaaca     5220

tcgtactcct ctcttcgtcc tagattgagc tcgttataga gctggttctg gccctgcttg     5280

tacgcggggg cgtctgcgct cctgctgaac ttcactctca gttcacatcc tccttcttct     5340

tcttctggaa atcggcagct acagccatct tcctcttgag tagtttgtac tggtctcata     5400

aatggttgtt tgaatatata caggagtttc tttctgcccc gtttgcagta aagggtgata     5460

accagtgaca ggagaaggac cccacaagtc ccggccaagg gcgcccagat gtagatatca     5520

caggcgaagt ccagccccct cgtgtgcact gcgccccccg ccgctggccg gcacgcctct     5580

gggcgcaggg acaggggctg cgacgcgatg gtgggcgccg gtgttggtgg tcgcggcgct     5640

ggcgtcgtgg ttgaggagac ggtgactgag gttccttggc cccagtagtc catagcatag     5700

ctaccaccgt agtaataatg tttggcacag tagtaaatgg ctgtgtcatc agtttgcaga     5760

ctgttcattt ttaagaaaac ttggctcttg gagttgtcct tgatgatggt cagtctggat     5820

ttgagagctg aattatagta tgtggtttca ctaccccata ttactcccag ccactccaga     5880

ccctttcgtg gaggctggcg aatccagctt acaccatagt cgggtaatga gacccctgag     5940

acagtgcatg tgacggacag gctctgtgag ggcgccacca ggccaggtcc tgactcctgc     6000

agtttcacct cagatccgcc gccacccgac ccaccaccgc ccgagccacc gccacctgtg     6060

atctccagct tggtcccccc tccgaacgtg tacggaagcg tattaccctg ttggcgaagt     6120

aggtggcaat atcttcttgc tccaggttgc taattgtcag agaataatct gttccagacc     6180

cactgccact gaaccttgat gggactcctg agtgtaatct tgatgtatgg tagatcagga     6240

gtttaacagt tccatctggt ttctgctgat accaatttaa atatttacta atgtcctgac     6300

ttgccctgca actgatggtg actctgtctc ccagagaggc agacagggag gatgtagtct     6360

gtgtcatctg gatgtccggc ctggcggcgt ggagcagcaa ggccagcggc aggagcaagg     6420

cggtcactgg taaggccatg gatcctctag atcacgacac ctgaaatgga agaaaaaaac     6480

tttgaaccac tgtctgaggc ttgagaatga accaagatcc aaactcaaaa agggcaaatt     6540

ccaaggagaa ttacatcaag tgccaagctg gcctaacttc agtctccacc cactcagtgt     6600

ggggaaactc catcgcataa aacccctccc cccaacctaa agacgacgta ctccaaaagc     6660

tcgagaacta atcgaggtgc ctggacggcg cccggtactc agtggagtca catgaagcga     6720

cggctgagga cggaaaggcc cttttccttt gtgtgggaga aacttataca gggtagcata     6780

atgggctact gaccccgcct tcaaacctat ttggagacta taagtgaaaa tgactcaccc     6840

gcccgctctc ccggcacctt catcttgtcc tttccctcag aaagaggctg ggaggcagag     6900

gctgaggcag cggtggccgg gacggttagg agaaaaggag tctctgctgg ttttattctg     6960

cagctacctc cccaggaagt ggaggactgt ggggcctttg agaagcacct gccgacaggg     7020

ccaagaaatt cgcactcccc ctttcggttc acaggcagga agccctggag gtttgagggt     7080

ttggggtgtg tgtatgtatc tgtctgtctg aattttgctt tttctctcat ttgaccattg     7140

ttttaatgct ccttttttta aaaaaaataa ttcttatcta attcctatct tgattggtaa     7200

agtccatctc taggcaaata caagttctcg atggaaaaca ataagtaatg taaaatacag     7260

catagcaaaa ctttaacctc caaatcaagc ctctacttga atccttttct gagggatgaa     7320

taaggcatag gcatcagggg ctgttgccaa tgtgcattag ctgtttgcag cctcaccttc     7380

tttcatggag tttaagatat agtgtatttt cccaaggttt gaactagctc ttcatttctt     7440

tatgttttaa atgcactgac ctcccacatt ccctttttag taaaatattc agaaataatt     7500

taaatacatc attgcaatga aaataaatgt tttttattag gcagaatcca gatgctcaag     7560

gcccttcata atatccccca gtttagtagt tggacttagg gaacaaagga acctttaata     7620

gaaattggac agcaagaaag cgagcttagt gatacttgtg atcctctaga tcacgacacc     7680

tgaaatggaa gaaaaaaact gcaccttcat cttgtccttt ccctcagaaa gaggctggga     7740

ggcagaggct gaggcagcgg tggccgggac ggttaggaga aaaggagtct ctgctggttt     7800

tattctgcag ctacctcccc aggaagtgga ggactgtggg gcctttgaga agcacctgcc     7860

gacagggcca agaaattcgc actccccctt tcggttcaca ggcaggaagc cctggaggtt     7920

tgagggtttg gggtgtgtgt atgtatctgt ctgtctgaat tttgcttttt ctctcatttg     7980

accattgttt taatgctcct ttttttaaaa aaaataattc ttatctaatt cctatcttga     8040

ttggtaaagt ccatctctag gcaaatacaa gttctcgatg gaaaacaata agtaatgtaa     8100

aatacagcat agcaaaactt taacctccaa atcaagcctc tacttgaatc cttttctgag     8160

ggatgaataa ggcataggca tcaggggctg ttgccaatgt gcattagctg tttgcagcct     8220

caccttcttt catggagttt aagatatagt gtattttccc aaggtttgaa ctagctcttc     8280

atttctttat gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga     8340

aataatttaa atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat     8400

gctcaaggcc cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc     8460

tttaatagaa attggacagc aagaaagcga gcttagtgat acttgtaaaa agagacgcgt     8520

ctctaaaagt cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     8580

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     8640

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     8700

tgggccgcct ccccgcctgg aattcgagct cggtaccttt aagaccaatg acttacaagg     8760

cagctgtaga tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact     8820

cccaacgaag acaagatctg ctttttgctt gtactgggtc tctctggtta gaccagatct     8880

gagcctggga gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc     8940

cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc     9000

tcagaccctt ttagtcagtg tggaaaatct ctagcagtag tagttcatgt catcttatta     9060

ttcagtattt ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg     9120

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     9180

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc     9240

tctagctatc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     9300

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc     9360

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggga cgtatggcca     9420

caacctgggc tccccgggcg cgtactccac ctcacccatc atccacgctg ttttatgagt     9480

aaaggagaag aacttttcac tggagttgtc ccaattcttg ttgaattaga tggtgatgtt     9540

aatgggcaca aattttctgt cagtggagag ggtgaaggtg atgcaacata cggaaaactt     9600

acccttaaat ttatttgcac tactggaaaa ctacctgttc catggccaac acttgtcact     9660

actttctctt atggtgttca atgcttttca agatacccag atcatatgaa acggcatgac     9720

tttttcaaga gtgccatgcc cgaaggttat gtacaggaaa gaactatatt tttcaaagat     9780

gacgggaact acaagacacg tgctgaagtc aagtttgaag gtgataccct tgttaataga     9840

atcgagttaa aaggtattga ttttaaagaa gatggaaaca ttcttggaca caaattggaa     9900

tacaactata actcacacaa tgtatacatc atggcagaca aacaaaagaa tggaatcaaa     9960

gttaacttca aaattagaca caacattgaa gatggaagcg ttcaactagc agaccattat    10020

caacaaaata ctccaattgg cgatggccct gtccttttac cagacaacca ttacctgtcc    10080

acacaatctg ccctttcgaa agatcccaac gaaaagagag accacatggt ccttcttgag    10140

tttgtaacag ctgctgggat tacacatggc atggatgaac tatacaaata ggacctccat    10200

agaagacacc gggaccgatc caataacttc gtatagcata cattatacga agttatgcct    10260

ccggactcta gcgtttaaac ttaagcttgg gaagttccta ttccgaagtt cctattctct    10320

agaaagtata ggaacttcta ccgagctcgg atccactagt ccagtgtggt ggaattctgc    10380

agatatccag cacagtggcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca    10440

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc    10500

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg    10560

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg    10620

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag    10680

gcggaaagtt aaccctagaa agataatcat attgtgacgt acgttaaaga taatcatgcg    10740

taaaattgac gcatgtgttt tatcggtctg tatatcgagg tttatttatt aatttgaata    10800

gatattaagt tttattatat ttacacttac atactaataa taaattcaac aaacaattta    10860

tttatgttta tttatttatt aaaaaaaaac aaaaactcaa aatttcttct ataaagtaac    10920

aaaaaccagc tggggctcga agttcctata ctttctagag aataggaact tctatagtga    10980

gtcgaataag ggcgacacaa aatttattct aaatgcataa taaatactga taacatctta    11040

tagtttgtat tatattttgt attatcgttg acatgtataa ttttgatatc aaaaactgat    11100

tttcccttta ttattttcga gatttatttt cttaattctc tttaacaaac tagaaatatt    11160

gtatatacaa aaaatcataa ataatagatg aatagtttaa ttataggtgt tcatcaatcg    11220

aaaaagcaac gtatcttatt taaagtgcgt tgcttttttc tcatttataa ggttaaataa    11280

ttctcatata tcaagcaaag tgacaggcgc ccttaaatat tctgacaaat gctctttccc    11340

taaactcccc ccataaaaaa acccgccgaa gcgggttttt acgttatttg cggattaacg    11400

attactcgtt atcagaaccg cccagggggc ccgagcttaa gactggccgt cgttttacaa    11460

cacagaaaga gtttgtagaa acgcaaaaag gccatccgtc aggggccttc tgcttagttt    11520

gatgcctggc agttccctac tctcgccttc cgcttcctcg ctcactgact cgctgcgctc    11580

ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac    11640

agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa    11700

ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca    11760

caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc    11820

gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata    11880

cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta    11940

tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca    12000

gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga    12060

cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg    12120

tgctacagag ttcttgaagt ggtgggctaa ctacggctac actagaagaa cagtatttgg    12180

tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg    12240

caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag    12300

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa    12360

cgacgcgcgc gtaactcacg ttaagggatt ttggtcatga gcttgcgccg tcccgtcaag    12420

tcagcgtaat gctctgcttt tagaaaaact catcgagcat caaatgaaac tgcaatttat    12480

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa    12540

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc    12600

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga    12660

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc    12720

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac    12780

cgttattcat tcgtgattgc gcctgagcga ggcgaaatac gcgatcgctg ttaaaaggac    12840

aattacaaac aggaatcgag tgcaaccggc gcaggaacac tgccagcgca tcaacaatat    12900

tttcacctga atcaggatat tcttctaata cctggaacgc tgtttttccg gggatcgcag    12960

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagtggca    13020

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac    13080

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaag cgatagattg    13140

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca    13200

tgttggaatt taatcgcggc ctcgacgttt cccgttgaat atggctcata ttcttccttt    13260

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat    13320

gtatttagaa aaataaacaa ataggggtca gtgttacaac caattaacca attctgaaca    13380

ttatcgcgag cccatttata cctgaatatg gctcataaca ccccttgttt gcctggcggc    13440

agtagcgcgg tggtcccacc tgaccccatg ccgaactcag aagtgaaacg ccgtagcgcc    13500

gatggtagtg tggggactcc ccatgcgaga gtagggaact gccaggcatc aaataaaacg    13560

aaaggctcag tcgaaagact gggcctttcg cccgggctaa ttagggggtg tcgcccttat    13620

tcgactctat agtgaagttc ctattctcta gaaagtatag gaacttctga agt           13673


<210>  84
<211>  15025
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Dox-rapamycin inducible GAG POL ENV

<400>  84
gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga acatgaaata       60

acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa tcatgcgtca      120

ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat tgacaagcac      180

gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga cggattcgcg      240

ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac gcagactatc      300

tttctagggt taagacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca      360

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc      420

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc      480

atgaagaatc tgcttagggt taggcgtttt gaagttccta tactttctag agaataggaa      540

cttcggaata ggaacttcgg atgcaatttc ctcattttat taggaaagga cagtgggagt      600

ggcaccttcc agggtcaagg aaggcacggg ggaggggcaa acaacagatg gctggcaact      660

agaaggcaca gcgttagtga tacttgtggg ccagggcatt agccacacca gccaccactt      720

tctgataggc agcctgcact ggtggggtga attccgcgga agcttgtgta attgttaatt      780

tctctgtccc actccatcca ggtcgtgtga ttccaaatct gttccagaga tttattactc      840

caactagcat tccaaggcac agcagtggtg caaatgagtt ttccagagca accccaaatc      900

cccaggagct gttgatcctt taggtatctt tccacagcca ggattcttgc ctggagctgc      960

ttgatgcccc agactgtgag ttgcaacaga tgctgttgcg cctcaatagc cctcagcaaa     1020

ttgttctgct gctgcactat accagacaat aattgtctgg cctgtaccgt cagcgtcatt     1080

gacgctgcgc ccatagtgct tcctgctgct cccaagaacc caaggaacaa agctcctgcg     1140

gccgctccgg aattccatgt gttaatcctc atcctgtcta cttgccacac aatcatcacc     1200

tgccatctgt tttccataat ccctgatgat ctttgctttt cttcttggca ctacttttat     1260

gtcactatta tcttgtatta ctactgcccc ttcacctttc cagaggagct ttgctggtcc     1320

tttccaaact ggatctctgc tgtccctgta ataaacccga aaattttgaa tttttgtaat     1380

ttgtttttgt aattctttag tttgtatgtc tgttgctatt atgtctacta ttctttcccc     1440

tgcactgtac cccccaatcc ccccttttct tttaaaattg tggatgaata ctgccatttg     1500

tactgctgtc ttaagatgtt cagcctgatc tcttacctgt cctataattt tctttaattc     1560

tttattcata gattctatta ctccttgact ttggggattg tagggaatgc caaattcctg     1620

cttgatcccc gcccaccaac aggcggcctt aactgtagta ctggtgaaat tgctgccatt     1680

gtctgtatgt actgttttta ctggccatct tcctgctaat tttaagagga agtatgctgt     1740

ttcttgccct gtctctgctg gaattacttc tgcttctata tatccactgg ctacatgaac     1800

tgctaccaag ataacttttc cttctaaatg tgtacaatct agctgccata ttcctgggct     1860

acagtctact tgtccatgca tggcttcccc ttttagctga catttatcac agctggctac     1920

tatttctttt gctactacag gtggtaggtt aaaatcacta gccattgctc tccaattact     1980

gtgatatttc tcatgttctt cttgggcctt atctattcca tctaaaaata gtactttcct     2040

gattccagca ctgaccaatt tatctacttg ttcatttcct ccaattcctt tgtgtgctgg     2100

tacccatgcc aggtagactt tttccttttt tattaactgc tctattattt gactgactaa     2160

ctctgattca ctcttatctg gttgtgcttg aatgattccc aatgcatatt gtgagtctgt     2220

cactatgttt acttctaatc ccgaatcctg caaagctaga tgaattgctt gtaactcagt     2280

cttctgattt gttgtgtccg ttagggggac aactttttgt cttcctctgt cagttacata     2340

tcctgctttt cctaatttag tttccctatt ggctgcccca tctacataga aagtttctgc     2400

tcctattatg ggttctttct ctaactggta ccataacttc actaagggag gggtattgac     2460

aaactcccac tcaggaatcc aggtggcttg ccaatactct gtccaccatg cttcccatgt     2520

ttccttttgt atgggtaatt taaatttagg agtctttccc catattacta tgctttctgt     2580

ggctattttt tgtactgcct ctgttaattg tttcacatca ttagtgtggg cacccttcat     2640

tcttgcatac tttcctgttt tcagattttt aaatggctct tgataaattt gatatgtcca     2700

ttggccttgc ccctgcttct gtatttctgc tattaagtct tttgatgggt cataatacac     2760

tccatgtacc ggttctttta gaatctccct gttttctgcc agttctagct ctgcttcttc     2820

tgttagtggt actacttctg ttagtgcttt ggttccccta agaagtttac ataattgcct     2880

tactttaatc cctgcataaa tctgacttgc ccaattcaat tttcccacta atttctgtat     2940

gtcattgaca gtccagctgt ccttttctgg cagcactata ggctgtactg tccatttatc     3000

aggatggagt tcataaccca tccaaaggaa tggaggttct ttctgatgtt ttttgtctgg     3060

tgtggtaaat ccccacctca acagatgttg tctcagttcc tctatttttg ttctatgctg     3120

ccctatttct aagtcagatc ctacatacaa atcatccatg tattgataga tgactatgtc     3180

tggattttgt tttctaaaag gctctaagat ttttgtcatg ctacactgga atattgctgg     3240

tgatcctttc catccctgtg gaagcacatt gtactgatat ctaatccctg gtgtctcatt     3300

gtttatacta ggtatggtaa atgcagtata cttcctgaag tctttatcta agggaactga     3360

aaaatatgca tcgcccacat ccagtactgt tactgatttt ttctgtttta accctgcagg     3420

atgtggtatt cctaattgaa cttcccagaa atcttgagtt ctcttattaa gttctctgaa     3480

atctactaat tttctccatt tagtactgtc ttttttcttt atggcaaata ctggagtatt     3540

gtatggattt tcaggcccaa tttttgaaat ttttccttcc ttttccattt ctgtacaaat     3600

ttctactaat gcttttattt tttcttctgt caatggccat tgtttaactt ttgggccatc     3660

cattcctggc tttaatttta ctggtacagt ctcaatagga ctaatgggaa aatttaaagt     3720

gcagccaatc tgagtcaaca gatttcttcc aattatgttg acaggtgtag gtcctactaa     3780

tactgtacct atagctttat gtccgcagat ttctatgagt atctgatcat actgtcttac     3840

tttgataaaa cctccaattc cccctatcat ttttggtttc catcttcctg gcaaattcat     3900

ttcttctaat actgtatcat ctgctcctgt atctaataga gcttccttta attgcccccc     3960

tatctttatt gtgacgaggg gtcgctgcca aagagtgatc tgagggaagc taaaggatac     4020

agttccttgt ctatcggctc ctgcttctga gagggagttg ttgtctcttc cccaaacctg     4080

aagctctctt ctggtggggc tgttggctct ggtctgctct gaagaaaatt ccctggcctt     4140

cccttgtggg aaggccagat cttccctaaa aaattagcct gtctctcagt acaatctttc     4200

atttggtgtc cttcctttcc acatttccaa cagccctttt tcctaggggc cctgcaattt     4260

ttggctatgt gcccttcttt gccacaattg aaacacttaa cagtctttct ttggttccta     4320

aaattgcctt tctgtatcat tatggtagct ggatttgtta cttggctcat tgcttcagcc     4380

aaaactcttg ctttatggcc gggtcccccc actccctgac atgctgtcat catttcttct     4440

agtgtcgctc ctggtcccaa tgcttttaaa atagtcttac aatctgggtt cgcattttgg     4500

accaacaagg tttctgtcat ccaatttttt acctcttgtg aagcttgctc ggctcttaga     4560

gttttataga atcggtctac atagtctcta aagggttcct ttggtccttg tcttatgtcc     4620

agaatgctgg tagggctata cattcttact attttattta atcccaggat tatccatctt     4680

ttatagattt ctcctactgg gataggtgga ttatgtgtca tccatcctat ttgttcctga     4740

agggtactag tagttcctgc tatgtcactt ccccttggtt ctctcatctg gcctggtgca     4800

ataggccctg catgcactgg atgcactcta tcccattctg cagcttcctc attgatggtc     4860

tcttttaaca tttgcatggc tgcttgatgt ccccccactg tgtttagcat ggtgtttaaa     4920

tcttgtgggg tggctccttc tgataatgct gaaaacatgg gtatcacttc tgggctgaaa     4980

gccttctctt ctactacttt tacccatgca tttaaagttc taggtgatat ggcctgatgt     5040

accatttgcc cctggatgtt ctgcactata gggtaatttt ggctgacctg attgctgtgt     5100

cctgtgtcag ctgctgcttg ctgtgctttt ttcttacttt tgttttgctc ttcctctatc     5160

ttgtctaaag cttccttggt gtcttttatc tctatccttt gatgcacaca atagagggtt     5220

gctactgtat tatataatga tctaagttct tctgatcctg tctgaaggga tggttgtagc     5280

tgtcccagta tttgtctaca gccttctgat gtttctaaca ggccaggatt aactgcgaat     5340

cgttctagct ccctgcttgc ccatactata tgttttaatt tatatttttt ctttccccct     5400

ggccttaacc gaattttttc ccatcgatct aattctcccc cgcttaatac tgacgctctc     5460

gcacccatgg cggcggcaga tctcgaattc agatctcacg tgctttgcca aagtgatggg     5520

ccagcacaca gaccagcacg ttgcccagga gctgtgggag gaagataaga ggtatgaaca     5580

tgattagcaa aagggcctag cttggactca gaataatcca gccttatccc aaccataaaa     5640

taaaagcaga atggtagctg gattgtagct gctattagca atatgaaacc tcttacatca     5700

gttacaattt atatgcagaa atatttatat gcagaaatat tgctattgcc ttaacccaga     5760

aattatcact gttattcttt agaatggtgc aaagaggcat gatacattgt atcattattg     5820

ccctgaaaga aagagattag ggaaagtatt agaaataaga taaacaaaaa agtatattaa     5880

aagaagaaag cattttttaa aattacaaat gcaaaattac cctgatttgg tcaatatgtg     5940

taccctgtta cttctcccct tcctatgaca tgaacttaac catagaaaag aaggggaaag     6000

aaaacatcaa gggtcccata gactcaccct gaagttctca ggatccgagc tcggtaccac     6060

atgtaagctt cgaggggagg ctggatcggt cccggtgtct tctatggagg tcaaaacagc     6120

gtggatggcg tctccaggcg atctgacggt tcactaaacg ctgcttcgcg atgtacgggc     6180

cagatatacg cgttgcgatc tgacggttca ctaaacgagc tctgcttata taggcctccc     6240

accgtacacg ccacctcgac atactcgagt ttactcccta tcagtgatag agaacgtatg     6300

aagagtttac tccctatcag tgatagagaa cgtatgcaga ctttactccc tatcagtgat     6360

agagaacgta taaggagttt actccctatc agtgatagag aacgtatgac cagtttactc     6420

cctatcagtg atagagaacg tatctacagt ttactcccta tcagtgatag agaacgtata     6480

tccagtttac tccctatcag tgatagagaa cgtataagct ttaggcgtgt acggtgggcg     6540

cctataaaag cagagctcgt ttagtgaacc gtcagatcgc ctggagcaat tccacaacac     6600

ttttgtctta taccaacttt ccgtaccact tcctaccctc gtaaatcgtc gacgagctcg     6660

tttagtgaac cgtcagatcg cctggagacg ccctcgaagc cgcggtgcgg gtgccagggc     6720

gtgcccttgg gctccatgtc catcatgggt ctcaaggtga acgtctctgc catattcatg     6780

gcagtactgt taactctcca aacacccacc ggtcaaatcc attggggcaa tctctctaag     6840

ataggggtgg taggaatagg aagtgcaagc tacaaagtta tgactcgttc cagccatcaa     6900

tcattagtca taaaattaat gcccaatata actctcctca ataactgcac gagggtagag     6960

attgcagaat acaggagact actgagaaca gttttggaac caattagaga tgcacttaat     7020

gcaatgaccc agaatataag accggttcag agtgtagctt caagtaggag acacaagaga     7080

tttgcgggag tagtcctggc aggtgcggcc ctaggcgttg ccacagctgc tcagataaca     7140

gccggcattg cacttcacca gtccatgctg aactctcaag ccatcgacaa tctgagagcg     7200

agcctggaaa ctactaatca ggcaattgag gcaatcagac aagcagggca ggagatgata     7260

ttggctgttc agggtgtcca agactacatc aataatgagc tgataccgtc tatgaaccaa     7320

ctatcttgtg atttaatcgg ccagaagctc gggctcaaat tgctcagata ctatacagaa     7380

atcctgtcat tatttggccc cagcttacgg gaccccatat ctgcggagat atctatccag     7440

gctttgagct atgcgcttgg aggagacatc aataaggtgt tagaaaagct cggatacagt     7500

ggaggtgatt tactgggcat cttagagagc agaggaataa aggcccggat aactcacgtc     7560

gacacagagt cctacttcat tgtcctcagt atagcctatc cgacgctgtc cgagattaag     7620

ggggtgattg tccaccggct agagggggtc tcgtacaaca taggctctca agagtggtat     7680

accactgtgc ccaagtatgt tgcaacccaa gggtacctta tctcgaattt tgatgagtca     7740

tcgtgtactt tcatgccaga ggggactgtg tgcagccaaa atgccttgta cccgatgagt     7800

cctctgctcc aagaatgcct ccgggggtcc accaagtcct gtgctcgtac actcgtatcc     7860

gggtcttttg ggaaccggtt cattttatca caagggaacc taatagccaa ttgtgcatca     7920

atcctttgca agtgttacac aacaggaacg atcattaatc aagaccctga caagatccta     7980

acatacattg ctgccgatca ctgcccggta gtcgaggtga acggcgtgac catccaagtc     8040

gggagcagga ggtatccaga cgctgtgtac ttgcacagaa ttgacctcgg tcctcccata     8100

tcattggaga ggttggacgt agggacaaat ctggggaatg caattgctaa gttggaggat     8160

gccaaggaat tgttggagtc atcggaccag atattgagga gtatgaaagg tttatcgagc     8220

actagcatag tctacatcct gattgcagtg tgtcttggag ggttgatagg gatccccgct     8280

ttaatatgtt gctgcagggg gcgttgaccc ctctccctcc ccccccccta acgttactgg     8340

ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt     8400

gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc     8460

taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc     8520

agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg     8580

gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc     8640

tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa     8700

atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg     8760

tatgggatct gatctggggc ctcggtacac atgctttaca tgtgtttagt cgaggttaaa     8820

aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata     8880

atatggccac aaccatggga agtaggatag tcattaacag agaacatctt atgattgata     8940

gaccttatgt tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag     9000

ccattgcagg cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc     9060

tcagcaccaa tctagatgta actaactcaa tcgagcatca ggtcaaggac gtgctgacac     9120

cactcttcaa aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc     9180

tagtgaaatt catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca     9240

gagatctcac ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact     9300

gtgcagatgt ggctgctgaa gagctcatga atgcattggt gaactcaact ctactggaga     9360

ccagaacaac caatcagttc ctagctgtct caaagggaaa ctgctcaggg cccactacaa     9420

tcagaggtca attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt     9480

acaatgtgtc atctatagtc actatgacat cccagggaat gtatggggga acttacctag     9540

tggaaaagcc taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag     9600

tgtttgaagt aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa     9660

actatcttga gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc     9720

tcaaactcgc agccctttgt cacggggaag attctatcac aattccctat cagggatcag     9780

ggaaaggtgt cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc     9840

aatcctgggt ccccttatca acggatgatc cagtgataga caggctttac ctctcatctc     9900

acagaggtgt tatcgctgac aaycaagcaa aatgggctgt cccgacaaca cgaacagatg     9960

acaagttgcg aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct    10020

gcgagaatcc cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt    10080

ctgttgatct gagtctgaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat    10140

tgatcacaca cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc    10200

tgactatccc rccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac    10260

cgagattcaa ggttagtccc tacctcttca mtgtcccaat taaggaagca ggcgaagact    10320

gccatgcccc aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc    10380

tggtgattct acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg    10440

ttgaacatgc tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc    10500

cttttaggtt gcctataaag ggggtcccca tcgaattaca agtggaatgc ttcacatggg    10560

accaaaaact ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata    10620

tcactcactc tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa    10680

ccaatcgcag atagggctgc tagtgaacya atcwcatgat gtcacccaga catcaggcat    10740

acccactagt gtgaaataga catcagaatt aagaaaaatg ggctccccgg gcgcgtactc    10800

cacctcaccc atcatccacg ctcggcaata aaaagacaga ataaaacgca cgggtgttgg    10860

gtcgtttgtt cgccgggcgc gtactccacc tcacccatca tccacgctgt tttatggata    10920

gcactgagaa cgtcatcaag cccttcatgc gcttcaaggt gcacatggag ggctccgtga    10980

acggccacga gttcgagatc gagggcgagg gcgagggcaa gccctacgag ggcacccaga    11040

ccgccaagct gcaggtgacc aagggcggcc ccctgccctt cgcctgggac atcctgtccc    11100

cccagttcca gtacggctcc aaggtgtacg tgaagcaccc cgccgacatc cccgactaca    11160

agaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc gaggacggcg    11220

gcgtggtgac cgtgacccag gactcctccc tgcaggacgg caccttcatc taccacgtga    11280

agttcatcgg cgtgaacttc ccctccgacg gccccgtaat gcagaagaag actctgggct    11340

gggagccctc caccgagcgc ctgtaccccc gcgacggcgt gctgaagggc gagatccaca    11400

aggcgctgaa gctgaagggc ggcggccact acctggtgga gttcaagtca atctacatgg    11460

ccaagaagcc cgtgaagctg cccggctact actacgtgga ctccaagctg gacatcacct    11520

cccacaacga ggactacacc gtggtggagc agtacgagcg cgccgaggcc cgccaccacc    11580

tgttccagta ggacctccat agaagacacc gggaccgatc caataacttc gtatagcata    11640

cattatacga agttatgcct ccggactcta gcgtttaaac ttaagcttgg taccgagctc    11700

ggatccacta gtccagtgtg gtggaattct gcagatatcc agcacagtgg cggccgctcg    11760

agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc    11820

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg    11880

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc    11940

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg    12000

ctggggatgc ggtgggctct atggcttctg aggcggaaag ttaaccctag aaagataatc    12060

atattgtgac gtacgttaaa gataatcatg cgtaaaattg acgcatgtgt tttatcggtc    12120

tgtatatcga ggtttattta ttaatttgaa tagatattaa gttttattat atttacactt    12180

acatactaat aataaattca acaaacaatt tatttatgtt tatttattta ttaaaaaaaa    12240

acaaaaactc aaaatttctt ctataaagta acaaaaacca gctggggctc gaagttccta    12300

tactttctag agaataggaa cttctatagt gagtcgaata agggcgacac aaaatttatt    12360

ctaaatgcat aataaatact gataacatct tatagtttgt attatatttt gtattatcgt    12420

tgacatgtat aattttgata tcaaaaactg attttccctt tattattttc gagatttatt    12480

ttcttaattc tctttaacaa actagaaata ttgtatatac aaaaaatcat aaataataga    12540

tgaatagttt aattataggt gttcatcaat cgaaaaagca acgtatctta tttaaagtgc    12600

gttgcttttt tctcatttat aaggttaaat aattctcata tatcaagcaa agtgacaggc    12660

gcccttaaat attctgacaa atgctctttc cctaaactcc ccccataaaa aaacccgccg    12720

aagcgggttt ttacgttatt tgcggattaa cgattactcg ttatcagaac cgcccagggg    12780

gcccgagctt aagactggcc gtcgttttac aacacagaaa gagtttgtag aaacgcaaaa    12840

aggccatccg tcaggggcct tctgcttagt ttgatgcctg gcagttccct actctcgcct    12900

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca    12960

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac    13020

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt    13080

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg    13140

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc    13200

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc    13260

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc    13320

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac    13380

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt    13440

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtgggct    13500

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc    13560

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt    13620

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg    13680

atcttttcta cggggtctga cgctcagtgg aacgacgcgc gcgtaactca cgttaaggga    13740

ttttggtcat gagcttgcgc cgtcccgtca agtcagcgta atgctctgct tttagaaaaa    13800

ctcatcgagc atcaaatgaa actgcaattt attcatatca ggattatcaa taccatattt    13860

ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg aggcagttcc ataggatggc    13920

aagatcctgg tatcggtctg cgattccgac tcgtccaaca tcaatacaac ctattaattt    13980

cccctcgtca aaaataaggt tatcaagtga gaaatcacca tgagtgacga ctgaatccgg    14040

tgagaatggc aaaagtttat gcatttcttt ccagacttgt tcaacaggcc agccattacg    14100

ctcgtcatca aaatcactcg catcaaccaa accgttattc attcgtgatt gcgcctgagc    14160

gaggcgaaat acgcgatcgc tgttaaaagg acaattacaa acaggaatcg agtgcaaccg    14220

gcgcaggaac actgccagcg catcaacaat attttcacct gaatcaggat attcttctaa    14280

tacctggaac gctgtttttc cggggatcgc agtggtgagt aaccatgcat catcaggagt    14340

acggataaaa tgcttgatgg tcggaagtgg cataaattcc gtcagccagt ttagtctgac    14400

catctcatct gtaacatcat tggcaacgct acctttgcca tgtttcagaa acaactctgg    14460

cgcatcgggc ttcccataca agcgatagat tgtcgcacct gattgcccga cattatcgcg    14520

agcccattta tacccatata aatcagcatc catgttggaa tttaatcgcg gcctcgacgt    14580

ttcccgttga atatggctca tattcttcct ttttcaatat tattgaagca tttatcaggg    14640

ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt    14700

cagtgttaca accaattaac caattctgaa cattatcgcg agcccattta tacctgaata    14760

tggctcataa caccccttgt ttgcctggcg gcagtagcgc ggtggtccca cctgacccca    14820

tgccgaactc agaagtgaaa cgccgtagcg ccgatggtag tgtggggact ccccatgcga    14880

gagtagggaa ctgccaggca tcaaataaaa cgaaaggctc agtcgaaaga ctgggccttt    14940

cgcccgggct aattaggggg tgtcgccctt attcgactct atagtgaagt tcctattctc    15000

tagaaagtat aggaacttct gaagt                                          15025


<210>  85
<211>  6584
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Rapamycin-inducible TET activator

<400>  85
gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga acatgaaata       60

acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa tcatgcgtca      120

ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat tgacaagcac      180

gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga cggattcgcg      240

ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac gcagactatc      300

tttctagggt taagacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca      360

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc      420

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc      480

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat      540

acgcgttctc catagaagac accgaataaa atatctttat tttcattaca tctgtgtgtt      600

ggttttttgt gtgaatcgat agtactaaca tacgctctcc atcaaaacaa aacgaaacaa      660

aacaaactag caaaataggc tgtccccagt gcaagtgcag gtgccagaac atttctctgg      720

accgatccaa taacttcgta tagcatacat tatacgaagt tatgcctccg gactctagcg      780

ttttagttat tactagcgct accggactca gatctcgagc tcaagcttcg aattctgcag      840

tcgacggtac cgcggcttac gcgtgctagc taatgatggg cgctcgagta atgatgggcg      900

gtcgactaat gatgggcgct cgagtaatga tgggcgtcta gctaatgatg ggcgctcgag      960

taatgatggg cggtcgacta atgatgggcg ctcgagtaat gatgggcgtc tagctaatga     1020

tgggcgctcg agtaatgatg ggcggtcgac taatgatggg cgctcgagta atgatgggcg     1080

tctagaacgc gaattaattc aacattttga cacccccata atatttttcc agaattaaca     1140

gtataaattg catctcttgt tcaagagttc cctatcactc tctttaatca ctactcacag     1200

taacctcaac tcctgccaca agcttgccct gcagcgggaa ttccaaactt aagcttggta     1260

ccgagctcgg atccactagt ccagtgtggt ggaattctgc agatatccag cacagtggcg     1320

gccgctcgag tctagagggc ccgtttaaac ccgctgatca atgtctagac tggacaagag     1380

caaagtcata aactctgctc tggaattact caatggagtc ggtatcgaag gcctgacgac     1440

aaggaaactc gctcaaaagc tgggagttga gcagcctacc ctgtactggc acgtgaagaa     1500

caagcgggcc ctgctcgatg ccctgccaat cgagatgctg gacaggcatc atacccactc     1560

ctgccccctg gaaggcgagt catggcaaga ctttctgcgg aacaacgcca agtcataccg     1620

ctgtgctctc ctctcacatc gcgacggggc taaagtgcat ctcggcaccc gcccaacaga     1680

gaaacagtac gaaaccctgg aaaatcagct cgcgttcctg tgtcagcaag gcttctccct     1740

ggagaacgca ctgtacgctc tgtccgccgt gggccacttt acactgggct gcgtattgga     1800

ggaacaggag catcaagtag caaaagagga aagagagaca cctaccaccg attctatgcc     1860

cccacttctg aaacaagcaa ttgagctgtt cgaccggcag ggagccgaac ctgccttcct     1920

tttcggcctg gaactaatca tatgtggcct ggagaaacag ctaaagtgcg aaagcggcgg     1980

gccgaccgac gcccttgacg attttgactt agacatgctc ccagccgatg cccttgacga     2040

ctttgacctt gatatgctgc ctgctgacgc tcttgacgat tttgaccttg acatgctccc     2100

cgggtaagtc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg     2160

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc     2220

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa     2280

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga     2340

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc     2400

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc     2460

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac     2520

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg     2580

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg     2640

gggacgtggt tttcctttga aaaacacgat gataaatgga tagcactgag aacgtcatca     2700

agcccttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac gagttcgaga     2760

tcgagggcga gggcgagggc aagccctacg agggcaccca gaccgccaag ctgcaggtga     2820

ccaagggcgg ccccctgccc ttcgcctggg acatcctgtc cccccagttc cagtacggct     2880

ccaaggtgta cgtgaagcac cccgccgaca tccccgacta caagaagctg tccttccccg     2940

agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc     3000

aggactcctc cctgcaggac ggcaccttca tctaccacgt gaagttcatc ggcgtgaact     3060

tcccctccga cggccccgta atgcagaaga agactctggg ctgggagccc tccaccgagc     3120

gcctgtaccc ccgcgacggc gtgctgaagg gcgagatcca caaggcgctg aagctgaagg     3180

gcggcggcca ctacctggtg gagttcaagt caatctacat ggccaagaag cccgtgaagc     3240

tgcccggcta ctactacgtg gactccaagc tggacatcac ctcccacaac gaggactaca     3300

ccgtggtgga gcagtacgag cgcgccgagg cccgccacca cctgttccag tagctcgact     3360

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     3420

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     3480

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     3540

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaagt     3600

taaccctaga aagataatca tattgtgacg tacgttaaag ataatcatgc gtaaaattga     3660

cgcatgtgtt ttatcggtct gtatatcgag gtttatttat taatttgaat agatattaag     3720

ttttattata tttacactta catactaata ataaattcaa caaacaattt atttatgttt     3780

atttatttat taaaaaaaaa caaaaactca aaatttcttc tataaagtaa caaaaaccag     3840

ctggggctcg aagttcctat actttctaga gaataggaac ttctatagtg agtcgaataa     3900

gggcgacaca aaatttattc taaatgcata ataaatactg ataacatctt atagtttgta     3960

ttatattttg tattatcgtt gacatgtata attttgatat caaaaactga ttttcccttt     4020

attattttcg agatttattt tcttaattct ctttaacaaa ctagaaatat tgtatataca     4080

aaaaatcata aataatagat gaatagttta attataggtg ttcatcaatc gaaaaagcaa     4140

cgtatcttat ttaaagtgcg ttgctttttt ctcatttata aggttaaata attctcatat     4200

atcaagcaaa gtgacaggcg cccttaaata ttctgacaaa tgctctttcc ctaaactccc     4260

cccataaaaa aacccgccga agcgggtttt tacgttattt gcggattaac gattactcgt     4320

tatcagaacc gcccaggggg cccgagctta agactggccg tcgttttaca acacagaaag     4380

agtttgtaga aacgcaaaaa ggccatccgt caggggcctt ctgcttagtt tgatgcctgg     4440

cagttcccta ctctcgcctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     4500

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     4560

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     4620

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     4680

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     4740

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     4800

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     4860

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     4920

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     4980

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     5040

gttcttgaag tggtgggcta actacggcta cactagaaga acagtatttg gtatctgcgc     5100

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     5160

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     5220

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgacgcgcg     5280

cgtaactcac gttaagggat tttggtcatg agcttgcgcc gtcccgtcaa gtcagcgtaa     5340

tgctctgctt ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag     5400

gattatcaat accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga     5460

ggcagttcca taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat     5520

caatacaacc tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat     5580

gagtgacgac tgaatccggt gagaatggca aaagtttatg catttctttc cagacttgtt     5640

caacaggcca gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca     5700

ttcgtgattg cgcctgagcg aggcgaaata cgcgatcgct gttaaaagga caattacaaa     5760

caggaatcga gtgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg     5820

aatcaggata ttcttctaat acctggaacg ctgtttttcc ggggatcgca gtggtgagta     5880

accatgcatc atcaggagta cggataaaat gcttgatggt cggaagtggc ataaattccg     5940

tcagccagtt tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat     6000

gtttcagaaa caactctggc gcatcgggct tcccatacaa gcgatagatt gtcgcacctg     6060

attgcccgac attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat     6120

ttaatcgcgg cctcgacgtt tcccgttgaa tatggctcat attcttcctt tttcaatatt     6180

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     6240

aaaataaaca aataggggtc agtgttacaa ccaattaacc aattctgaac attatcgcga     6300

gcccatttat acctgaatat ggctcataac accccttgtt tgcctggcgg cagtagcgcg     6360

gtggtcccac ctgaccccat gccgaactca gaagtgaaac gccgtagcgc cgatggtagt     6420

gtggggactc cccatgcgag agtagggaac tgccaggcat caaataaaac gaaaggctca     6480

gtcgaaagac tgggcctttc gcccgggcta attagggggt gtcgccctta ttcgactcta     6540

tagtgaagtt cctattctct agaaagtata ggaacttctg aagt                      6584


<210>  86
<211>  11528
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Rapamycin inducer inducible REV srcVpx

<400>  86
gatatctata acaagaaaat atatatataa taagttatca cgtaagtaga acatgaaata       60

acaatataat tatcgtatga gttaaatctt aaaagtcacg taaaagataa tcatgcgtca      120

ttttgactca cgcggtcgtt atagttcaaa atcagtgaca cttaccgcat tgacaagcac      180

gcctcacggg agctccaagc ggcgactgag atgtcctaaa tgcacagcga cggattcgcg      240

ctatttagaa agagagagca atatttcaag aatgcatgcg tcaattttac gcagactatc      300

tttctagggt taagacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca      360

atctgctctg atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc      420

gctgagtagt gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc      480

atgaagaatc tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat      540

acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt      600

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      660

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      720

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      780

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      840

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      900

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      960

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt     1020

ttgttttgga accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg     1080

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcggcattga     1140

ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     1200

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     1260

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     1320

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat     1380

catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     1440

gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc     1500

gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac     1560

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa     1620

aatcaacggg actttccaaa atgtcgtaac aactgcgatc gcccgccccg ttgacgcaaa     1680

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     1740

agatcactag aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg     1800

cttctgacac aacagtctcg aacttaagct gcagtgactc tcttaaggta gccttgcaga     1860

agttggtcgt gaggcactgg gcaggtaagt atcaaggtta caagacaggt ttaaggagac     1920

caatagaaac tgggcttgtc gagacagaga agactcttgc gtttctgata ggcacctatt     1980

ggtcttactg acatccactt tgcctttctc tccacaggtg tccactccca gttcaattac     2040

agctcttaag gctagagtac ttaatacgac tcactatagg ctagcctcga gaattcatgg     2100

cttctagaat cctctggcat gagatgtggc atgaaggcct ggaagaggca tctcgtttgt     2160

actttgggga aaggaacgtg aaaggcatgt ttgaggtgct ggagcccttg catgctatga     2220

tggaacgggg cccccagact ctgaaggaaa catcctttaa tcaggcctat ggtcgagatt     2280

taatggaggc ccaagagtgg tgcaggaagt acatgaaatc agggaatgtc aaggacctcc     2340

tccaagcctg ggacctctat tatcatgtgt tccgacgaat ctcaaagact agagatgagt     2400

ttcccaccat ggtgtttcct tctgggcaga tcagccaggc ctcggccttg gccccggccc     2460

ctccccaagt cctgccccag gctccagccc ctgcccctgc tccagccatg gtatcagctc     2520

tggcccaggc cccagcccct gtcccagtcc tagccccagg ccctcctcag gctgtggccc     2580

cacctgcccc caagcccacc caggctgggg aaggaacgct gtcagaggcc ctgctgcagc     2640

tgcagtttga tgatgaagac ctgggggcct tgcttggcaa cagcacagac ccagctgtgt     2700

tcacagacct ggcatccgtc gacaactccg agtttcagca gctgctgaac cagggcatac     2760

ctgtggcccc ccacacaact gagcccatgc tgatggagta ccctgaggct ataactcgcc     2820

tagtgacagg ggcccagagg ccccccgacc cagctcctgc tccactgggg gccccggggc     2880

tccccaatgg cctcctttca ggagatgaag acttctcctc cattgcggac atggacttct     2940

cagccctgct gagtcagatc agctccacta gttattaaga attcacgcgt cgagcatgca     3000

tctagggcgg ccaattccgc ccctctcccc cccccccctc tccctccccc ccccctaacg     3060

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     3120

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     3180

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     3240

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     3300

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     3360

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     3420

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     3480

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     3540

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     3600

gatgataagc ttgccacaac ccgggatcct ctagagtcga catggactat cctgctgcca     3660

agagggtcaa gttggactct agagaacgcc catatgcttg ccctgtcgag tcctgcgatc     3720

gccgcttttc tcgctcggat gagcttaccc gccatatccg catccacaca ggccagaagc     3780

ccttccagtg tcgaatctgc atgcgtaact tcagtcgtag tgaccacctt accacccaca     3840

tccgcaccca cacaggcggc ggccgcagga ggaagaaacg caccagcata gagaccaaca     3900

tccgtgtggc cttagagaag agtttcttgg agaatcaaaa gcctacctcg gaagagatca     3960

ctatgattgc tgatcagctc aatatggaaa aagaggtgat tcgtgtttgg ttctgtaacc     4020

gccgccagaa agaaaaaaga atcaacacta gaggagtgca ggtggaaacc atctccccgg     4080

gagacgggcg caccttcccc aagcgcggcc agacctgcgt ggtgcactac accgggatgc     4140

ttgaagatgg aaagaaattt gattcctccc gggacagaaa caagcccttt aagtttatgc     4200

taggcaagca ggaggtgatc cgaggctggg aagaaggggt tgcccagatg agtgtgggtc     4260

agagagccaa actgactata tctccagatt atgcctatgg tgccactggg cacccaggca     4320

tcatcccacc acatgccact ctcgtcttcg atgtggagct tctaaaactg gaagtcgagg     4380

gcgtgcaggt ggaaaccatc tccccaggag acgggcgcac cttccccaag cgcggccaga     4440

cctgcgtggt gcactacacc gggatgcttg aagatggaaa gaaatttgat tcctcccggg     4500

acagaaacaa gccctttaag tttatgctag gcaagcagga ggtgatccga ggctgggaag     4560

aaggggttgc ccagatgagt gtgggtcaga gagccaaact gactatatct ccagattatg     4620

cctatggtgc cactgggcac ccaggcatca tcccaccaca tgccactctc gtcttcgatg     4680

tggagcttct aaaactggaa actagaggag tgcaggtgga aaccatctcc ccaggagacg     4740

ggcgcacctt ccccaagcgc ggccagacct gcgtggtgca ctacaccggg atgcttgaag     4800

atggaaagaa atttgattcc tcccgggaca gaaacaagcc ctttaagttt atgctaggca     4860

agcaggaggt gatccgaggc tgggaagaag gggttgccca gatgagtgtg ggtcagagag     4920

ccaaactgac tatatctcca gattatgcct atggtgccac tgggcaccca ggcatcatcc     4980

caccacatgc cactctcgtc ttcgatgtgg agcttctaaa actggaaact agttattaag     5040

tcgacccggg cggccgcttc cctttagtga gggttaatgc ttcgagcaga catgataaga     5100

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     5160

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     5220

ctccatagaa gacaccggga ccgatccaat aacttcgtat agcatacatt atacgaagtt     5280

atggctgcta gtgaacyaat cwcatgatgt cacccagaca tcaggcatac ccactagtgt     5340

gaaatagaca tcagaattaa gaaaaatggg ctccccgggc gcgtactcca cctcacccat     5400

catccacgct cggcaataaa aagacagaat aaaacgcacg ggtgttgggt cgtttgttcg     5460

ttttatggat agcactgaga acgtcatcaa gcccttcatg cgcttcaagg tgcacatgga     5520

gggctccgtg aacggccacg agttcgagat cgagggcgag ggcgagggca agccctacga     5580

gggcacccag accgccaagc tgcaggtgac caagggcggc cccctgccct tcgcctggga     5640

catcctgtcc ccccagttcc agtacggctc caaggtgtac gtgaagcacc ccgccgacat     5700

ccccgactac aagaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt     5760

cgaggacggc ggcgtggtga ccgtgaccca ggactcctcc ctgcaggacg gcaccttcat     5820

ctaccacgtg aagttcatcg gcgtgaactt cccctccgac ggccccgtaa tgcagaagaa     5880

gactctgggc tgggagccct ccaccgagcg cctgtacccc cgcgacggcg tgctgaaggg     5940

cgagatccac aaggcgctga agctgaaggg cggcggccac tacctggtgg agttcaagtc     6000

aatctacatg gccaagaagc ccgtgaagct gcccggctac tactacgtgg actccaagct     6060

ggacatcacc tcccacaacg aggactacac cgtggtggag cagtacgagc gcgccgaggc     6120

ccgccaccac ctgttccagt aggacctcca tagaagacac cgaataaaat atctttattt     6180

tcattacatc tgtgtgttgg ttttttgtgt gaatcgatag tactaacata cgctctccat     6240

caaaacaaaa cgaaacaaaa caaactagca aaataggctg tccccagtgc aagtgcaggt     6300

gccagaacat ttctctggac cgatccaata acttcgtata gcatacatta tacgaagtta     6360

tgcctccgga ctctagcgtt ttagttatta ctagcgctac cggactcaga tctcgagctc     6420

aagcttcgaa ttctgcagtc gacggtaccg cggcttacgc gtgctagcta atgatgggcg     6480

ctcgagtaat gatgggcggt cgactaatga tgggcgctcg agtaatgatg ggcgtctagc     6540

taatgatggg cgctcgagta atgatgggcg gtcgactaat gatgggcgct cgagtaatga     6600

tgggcgtcta gctaatgatg ggcgctcgag taatgatggg cggtcgacta atgatgggcg     6660

ctcgagtaat gatgggcgtc tagaacgcga attaattcaa cattttgaca cccccataat     6720

atttttccag aattaacagt ataaattgca tctcttgttc aagagttccc tatcactctc     6780

tttaatcact actcacagta acctcaactc ctgccacaag cttgccctgc agcgggaatt     6840

ccaaacttaa gcttggtacc gagctcggat ccactagtcc agtgtggtgg aattctgcag     6900

atatccagca cagtggcggc cgctcgagtc tagagggccc gtttaaaccc gctgatcaga     6960

tggcaggaag aagcggagac agcgacgaag acctcctcaa ggcagtcaga ctcatcaagt     7020

ttctctatca aagcaaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata     7080

gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa cggatcctta     7140

gcacttattt gggacgatct gcggacgctg tgcctcttca gctaccaccg cttgagagac     7200

ttactcttga ttgtgacgag gattgtggaa cttctgggac gcagggggtg ggaagccctc     7260

aaatattggt ggaatctcct acaatattgg agtcaggagc taaagaatag tccctccccc     7320

ccccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg     7380

ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc     7440

ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg     7500

aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg     7560

accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca     7620

cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata     7680

gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc     7740

cagaaggtac cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt     7800

gtttagtcga ggttaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     7860

gaaaaacacg atgataatgg ggaggaggaa gaggaagccg aaggatccga aggcgagggt     7920

gttggcggag gcggattaca aggacgacga tgacaagatg tcagatccca gggagagaat     7980

cccacctgga aacagtggag aagagacaat aggagaggcc ttcgaatggc taaacagaac     8040

agtagaggag ataaacagag aggcagtaaa ccacctacca agggagctga ttttccaggt     8100

ttggcaaagg tcttgggaat actggcatga tgaacaaggg atgtcacaaa gctatgtaaa     8160

atacagatac ttgtgtttaa tgcaaaaggc tttatttatg cattgcaaga aaggctgtag     8220

atgtctaggg gaaggacacg gggcaggagg atggagacca ggacctcctc ctcctccccc     8280

tccaggacta gcataacctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     8340

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     8400

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     8460

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     8520

tctatggctt ctgaggcgga aagttaaccc tagaaagata atcatattgt gacgtacgtt     8580

aaagataatc atgcgtaaaa ttgacgcatg tgttttatcg gtctgtatat cgaggtttat     8640

ttattaattt gaatagatat taagttttat tatatttaca cttacatact aataataaat     8700

tcaacaaaca atttatttat gtttatttat ttattaaaaa aaaacaaaaa ctcaaaattt     8760

cttctataaa gtaacaaaaa ccagctgggg ctcgaagttc ctatactttc tagagaatag     8820

gaacttctat agtgagtcga ataagggcga cacaaaattt attctaaatg cataataaat     8880

actgataaca tcttatagtt tgtattatat tttgtattat cgttgacatg tataattttg     8940

atatcaaaaa ctgattttcc ctttattatt ttcgagattt attttcttaa ttctctttaa     9000

caaactagaa atattgtata tacaaaaaat cataaataat agatgaatag tttaattata     9060

ggtgttcatc aatcgaaaaa gcaacgtatc ttatttaaag tgcgttgctt ttttctcatt     9120

tataaggtta aataattctc atatatcaag caaagtgaca ggcgccctta aatattctga     9180

caaatgctct ttccctaaac tccccccata aaaaaacccg ccgaagcggg tttttacgtt     9240

atttgcggat taacgattac tcgttatcag aaccgcccag ggggcccgag cttaagactg     9300

gccgtcgttt tacaacacag aaagagtttg tagaaacgca aaaaggccat ccgtcagggg     9360

ccttctgctt agtttgatgc ctggcagttc cctactctcg ccttccgctt cctcgctcac     9420

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     9480

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     9540

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     9600

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     9660

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     9720

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     9780

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     9840

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     9900

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     9960

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg gctaactacg gctacactag    10020

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg    10080

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca    10140

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc    10200

tgacgctcag tggaacgacg cgcgcgtaac tcacgttaag ggattttggt catgagcttg    10260

cgccgtcccg tcaagtcagc gtaatgctct gcttttagaa aaactcatcg agcatcaaat    10320

gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa agccgtttct    10380

gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt    10440

ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa    10500

ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagtt    10560

tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac    10620

tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgaggcga aatacgcgat    10680

cgctgttaaa aggacaatta caaacaggaa tcgagtgcaa ccggcgcagg aacactgcca    10740

gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg aacgctgttt    10800

ttccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga    10860

tggtcggaag tggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat    10920

cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat    10980

acaagcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat ttatacccat    11040

ataaatcagc atccatgttg gaatttaatc gcggcctcga cgtttcccgt tgaatatggc    11100

tcatattctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg    11160

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggtcagtgtt acaaccaatt    11220

aaccaattct gaacattatc gcgagcccat ttatacctga atatggctca taacacccct    11280

tgtttgcctg gcggcagtag cgcggtggtc ccacctgacc ccatgccgaa ctcagaagtg    11340

aaacgccgta gcgccgatgg tagtgtgggg actccccatg cgagagtagg gaactgccag    11400

gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgcccgg gctaattagg    11460

gggtgtcgcc cttattcgac tctatagtga agttcctatt ctctagaaag tataggaact    11520

tctgaagt                                                             11528


<210>  87
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  87
gggcggcacu uauacagcga agcauaaugg cuacugacgc ccucaaaccc uauuugcaga       60

cuauaagugu cgcgcg                                                       76


<210>  88
<211>  73
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  88
gggcggcacu uauacagggu agcauaaugg cuuaggacgc cuucaaaccu aucaagacua       60

uaagugucgc gcg                                                          73


<210>  89
<211>  75
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  89
gggcggcacu uauacagggu agcauaaugg gcuacuugac gccuucaccu auuuguagac       60

uauaaguguc gcgcg                                                        75


<210>  90
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  90
gggcggcacu uauacagcgu agcauaaugg gcugcagacg ccgucaaacc uauuugcaga       60

cuauaagugu cgcgcg                                                       76


<210>  91
<211>  74
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  91
gggcggcacu uauacaccgu agcauaaugg gcuacugccg ccgucgaccu uuuggagacu       60

auaagugucg cgcg                                                         74


<210>  92
<211>  75
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  92
gggcggcacu uauacagguc agcauaaugu gcuagugcgc cuucaaaccu auuuagagac       60

uauaaguguc gcgcg                                                        75


<210>  93
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  93
gggcggcacu uauacagcuu agcguaaugg cuacugacgc cguccaaacc uauuuacaga       60

cuauaagugu cgcgcg                                                       76


<210>  94
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  94
gggcggcacu uauacagggg agcauaaugg gcuacugacg ccuuuaaacc uauuugagga       60

cuauaagugu cgcgcg                                                       76


<210>  95
<211>  74
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  95
gggcggcacu uauacaugga agcauaaugg gcugccgacg gcccuuaacc uuuggagacu       60

auaagugucg cgcg                                                         74


<210>  96
<211>  79
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  96
gggcggcacu uauacagauu agcauaaugg gcuacugacc ccgccggcaa accuauuuga       60

agacuauaag ugucgcgcg                                                    79


<210>  97
<211>  75
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  97
gggcggcacu uauacagugu agcauaaugg gcuacugucg caucaaaccu auuuggagac       60

uauaaguguc gcgcg                                                        75


<210>  98
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  98
gggcggcacu uauacaguga agcauaaugg gcuacugaca cccuuaaacc uauuugcaga       60

cuauaagugu cgcgcg                                                       76


<210>  99
<211>  76
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  99
gggcggcacu uauacagagu agcauaaugg gcuacagacg ccgucaaacc uauuuaccga       60

cuauaagugu cgcgcg                                                       76


<210>  100
<211>  75
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Evolved aptamer

<400>  100
gggcggcacu uauacagggu gcauaauggg cuagugacgc cuucaaaccu auuuguagac       60

uauaaguguc gcgcg                                                        75


<210>  101
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Lys Cys His Leu Ser Phe Phe Ser Val Ala 
                245                 250                 255     


Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro 
            260                 265                 270         


Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu 
        275                 280                 285             


Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser 
    290                 295                 300                 


Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp 
305                 310                 315                 320 


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
                325                 330                 335     


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
            340                 345                 350         


Ser Glu Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
        355                 360                 365             


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
    370                 375                 380                 


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
385                 390                 395                 400 


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
                405                 410                 415     


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
            420                 425                 430         


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
        435                 440                 445             


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 460     


<210>  102
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Phe Ser Cys Gly Pro Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser 
                245                 250                 255     


Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile 
            260                 265                 270         


Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu 
        275                 280                 285             


His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro 
    290                 295                 300                 


Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala 
305                 310                 315                 320 


Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu 
                325                 330                 335     


Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn 
            340                 345                 350         


Cys Pro Ser Glu Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp 
        355                 360                 365             


Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro 
    370                 375                 380                 


Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn 
385                 390                 395                 400 


Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn 
                405                 410                 415     


Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu 
            420                 425                 430         


Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn 
        435                 440                 445             


Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 460             


<210>  103
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Cys His Leu Ile Ser Ile Leu Ser Phe Phe Ser Val 
                245                 250                 255     


Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys 
            260                 265                 270         


Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His 
        275                 280                 285             


Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu 
    290                 295                 300                 


Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg 
305                 310                 315                 320 


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
                325                 330                 335     


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
            340                 345                 350         


Pro Ser Glu Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser 
        355                 360                 365             


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
    370                 375                 380                 


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
385                 390                 395                 400 


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
                405                 410                 415     


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
            420                 425                 430         


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
        435                 440                 445             


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 460         


<210>  104
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Pro Pro Val Cys Ser Val Thr Ile Ser Ile Leu Ser 
                245                 250                 255     


Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys 
            260                 265                 270         


Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys 
        275                 280                 285             


Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser 
    290                 295                 300                 


Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp 
305                 310                 315                 320 


Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
                325                 330                 335     


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
            340                 345                 350         


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Val Thr Pro Glu Ser Phe 
        355                 360                 365             


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
    370                 375                 380                 


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
385                 390                 395                 400 


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
                405                 410                 415     


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
            420                 425                 430         


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
        435                 440                 445             


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
    450                 455                 460                 


Asn Gln 
465     


<210>  105
<211>  523
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Fc-delta-30

<400>  105

Met Ser Ile Met Gly Leu Lys Val Asn Val Ser Ala Ile Phe Met Ala 
1               5                   10                  15      


Val Leu Leu Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn 
            20                  25                  30          


Leu Ser Lys Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val 
        35                  40                  45              


Met Thr Arg Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn 
    50                  55                  60                  


Ile Thr Leu Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg 
65                  70                  75                  80  


Arg Leu Leu Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala 
                85                  90                  95      


Met Thr Gln Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg 
            100                 105                 110         


His Lys Arg Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val 
        115                 120                 125             


Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met 
    130                 135                 140                 


Leu Asn Ser Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr 
145                 150                 155                 160 


Asn Gln Ala Ile Glu Ala Ile Arg Gln Ala Gly Gln Glu Met Ile Leu 
                165                 170                 175     


Ala Val Gln Gly Val Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser 
            180                 185                 190         


Met Asn Gln Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys 
        195                 200                 205             


Leu Leu Arg Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu 
    210                 215                 220                 


Arg Asp Pro Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala 
225                 230                 235                 240 


Leu Gly Gly Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly 
                245                 250                 255     


Gly Asp Leu Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile 
            260                 265                 270         


Thr His Val Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr 
        275                 280                 285             


Pro Thr Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly 
    290                 295                 300                 


Val Ser Tyr Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys 
305                 310                 315                 320 


Tyr Val Ala Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser 
                325                 330                 335     


Cys Thr Phe Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr 
            340                 345                 350         


Pro Met Ser Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser 
        355                 360                 365             


Cys Ala Arg Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu 
    370                 375                 380                 


Ser Gln Gly Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys 
385                 390                 395                 400 


Tyr Thr Thr Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr 
                405                 410                 415     


Tyr Ile Ala Ala Asp His Cys Pro Val Val Glu Val Asn Gly Val Thr 
            420                 425                 430         


Ile Gln Val Gly Ser Arg Arg Tyr Pro Asp Ala Val Tyr Leu His Arg 
        435                 440                 445             


Ile Asp Leu Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr 
    450                 455                 460                 


Asn Leu Gly Asn Ala Ile Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu 
465                 470                 475                 480 


Glu Ser Ser Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr 
                485                 490                 495     


Ser Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly 
            500                 505                 510         


Ile Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg 
        515                 520             


<210>  106
<211>  599
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Hc-delta-18

<400>  106

Met Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile Asp Arg 
1               5                   10                  15      


Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Ser Leu Ser Leu Ile 
            20                  25                  30          


Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala Ile Tyr 
        35                  40                  45              


Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val Thr Asn 
    50                  55                  60                  


Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe Lys Ile 
65                  70                  75                  80  


Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr Asp Leu 
                85                  90                  95      


Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp Arg Glu 
            100                 105                 110         


Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu Arg Ile 
        115                 120                 125             


Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu Glu Leu 
    130                 135                 140                 


Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr Thr Asn 
145                 150                 155                 160 


Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr Thr Ile 
                165                 170                 175     


Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu Tyr Leu 
            180                 185                 190         


Ser Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser Gln Gly 
        195                 200                 205             


Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser Ser Lys 
    210                 215                 220                 


Arg Ser Glu Leu Ser Gln Leu Ser Met Tyr Arg Val Phe Glu Val Gly 
225                 230                 235                 240 


Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met Thr Asn 
                245                 250                 255     


Tyr Leu Glu Gln Pro Val Ser Asn Asp Leu Ser Asn Cys Met Val Ala 
            260                 265                 270         


Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp Ser Ile 
        275                 280                 285             


Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln Leu Val 
    290                 295                 300                 


Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp Val Pro 
305                 310                 315                 320 


Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser Ser His 
                325                 330                 335     


Arg Gly Val Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro Thr Thr 
            340                 345                 350         


Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln Ala Cys 
        355                 360                 365             


Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu 
    370                 375                 380                 


Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp Leu Ser 
385                 390                 395                 400 


Leu Thr Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu 
                405                 410                 415     


Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His Asn Asn 
            420                 425                 430         


Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu Gly Val 
        435                 440                 445             


Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro Asn Leu 
    450                 455                 460                 


Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala Pro Thr 
465                 470                 475                 480 


Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser Asn Leu 
                485                 490                 495     


Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp 
            500                 505                 510         


Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser Pro Gly 
        515                 520                 525             


Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val 
    530                 535                 540                 


Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp 
545                 550                 555                 560 


Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly His Ile 
                565                 570                 575     


Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val Thr Arg 
            580                 585                 590         


Glu Asp Gly Thr Asn Arg Arg 
        595                 


<210>  107
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic DAFss-IL7-DAF fusion

<400>  107

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Asp 
            20                  25                  30          


Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met 
        35                  40                  45              


Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn 
    50                  55                  60                  


Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala 
65                  70                  75                  80  


Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln 
                85                  90                  95      


Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys 
            100                 105                 110         


Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys 
        115                 120                 125             


Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu 
    130                 135                 140                 


Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys 
145                 150                 155                 160 


Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile 
                165                 170                 175     


Leu Met Gly Thr Lys Glu His Cys Gly Leu Pro Pro Asp Val Pro Asn 
            180                 185                 190         


Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val 
        195                 200                 205             


Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys 
    210                 215                 220                 


Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu 
225                 230                 235                 240 


Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser 
                245                 250                 255     


Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val 
            260                 265                 270         


Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser 
        275                 280                 285             


Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu 
    290                 295                 300                 


Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly 
305                 310                 315                 320 


Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe 
                325                 330                 335     


Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys 
            340                 345                 350         


Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys 
        355                 360                 365             


Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile 
    370                 375                 380                 


Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala 
385                 390                 395                 400 


Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr 
                405                 410                 415     


Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg 
            420                 425                 430         


Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr 
        435                 440                 445             


Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr 
    450                 455                 460                 


Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro 
465                 470                 475                 480 


Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly 
                485                 490                 495     


Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys 
            500                 505                 510         


Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu 
        515                 520                 525             


Thr 
    


<210>  108
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-1

<400>  108
acagcttagc gtaatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  109
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-2

<400>  109
acagcttagg ataatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  110
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-3

<400>  110
acagcttagc ataatggcta ctgacgccgt ccaaacctat tcacagact                   49


<210>  111
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-4

<400>  111
acagcttagc ataatggcta ctgacgccgt ccaaacctat tgacagact                   49


<210>  112
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-5

<400>  112
acagcatagc ataatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  113
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-6

<400>  113
acagcttagc ataatggcta ctgacgccgt ccaaacctat gtacagact                   49


<210>  114
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-7

<400>  114
acagctagcg taatggctac tgacgccgtc caaacctatt tacagact                    48


<210>  115
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-8

<400>  115
acagcttagc attatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  116
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-9

<400>  116
acagttagca taatggctac tgacgccgtc caaacctatt tacagact                    48


<210>  117
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-10

<400>  117
acagcttagc ataatggcta ctgacgcggt ccaaacctat ttacagact                   49


<210>  118
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-11

<400>  118
acagcttagc ttaatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  119
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-12

<400>  119
acagcttagc ataatggcta ctgacgccgt ccaaacccat ttacagact                   49


<210>  120
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-13

<400>  120
acagcttagc ataatggcta ctgacgccgt ccaaaccaat ttacagact                   49


<210>  121
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-14

<400>  121
acagcttagc ataatggata ctgacgccgt ccaaacctat ttacagact                   49


<210>  122
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-15

<400>  122
acagcttagc attgtggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  123
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-16

<400>  123
acaggttagc ataatggcta ccgacgccgt ccaaacctat ttacagact                   49


<210>  124
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-17

<400>  124
acagcttagc gtaatggcta ctgacgccgc ccaaacctat ttacagact                   49


<210>  125
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-18

<400>  125
acagcttagc ataatggcta ctgacgccgt ccaaaactat ttccagact                   49


<210>  126
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-19

<400>  126
acagcctagc ataagggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  127
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-20

<400>  127
acagcttagc ataatggcta ctgaggccgt ccaaacctat ttacagact                   49


<210>  128
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-21

<400>  128
acagcttacc ttaatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  129
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-22

<400>  129
acagcttagc ataatggcta ccgacgctgt ccaaacctat ttacagact                   49


<210>  130
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-23

<400>  130
acagcttagc gtaatggcta ctggcgccgt ccaaacctat ttacagact                   49


<210>  131
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-24

<400>  131
acagcttagc atactggcta ctgacgccgc ccaaacctat ttacagact                   49


<210>  132
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-25

<400>  132
acagcttagc ataatggcta ctgacgccgt cctaacctat ttacagact                   49


<210>  133
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-26

<400>  133
acaggttagc ataatgccta ctgacgccgt ccaaacctat ttacagact                   49


<210>  134
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-27

<400>  134
acagcttagc ataattgcta ctgacgccgt tcaaacctat ttacagact                   49


<210>  135
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-28

<400>  135
acagcttagc ataaaggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  136
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-29

<400>  136
acagcttagc gtaatggcta ctgacgccgt ctaaacctat ttccagact                   49


<210>  137
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-30

<400>  137
acaggttagc ataatggcta ctgacgccgt ccaaacctat ttagagact                   49


<210>  138
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-31

<400>  138
acagggtagc gtaatggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  139
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-32

<400>  139
acagcgtagc ataatggcta ctgacgccgt tcaaacctat ttacagact                   49


<210>  140
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-33

<400>  140
acagcttagc ataatggcta ctgacgccgt ccaaactcat ttacagact                   49


<210>  141
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-34

<400>  141
acagcgtagc atagtggcta ctgacgccgt ccaaacctat ttacagact                   49


<210>  142
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-35

<400>  142
acagcttagt gtaatggcta ctgacgctgt ccaaacctat ttacagact                   49


<210>  143
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-36

<400>  143
acagcttagc ataatggcta ctgacggcgt tcaaacctat ttacagact                   49


<210>  144
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-37

<400>  144
acaggttagc ataatggcta ctgacgccgt ccaaacctat ttatagact                   49


<210>  145
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-38

<400>  145
acagcttagc ataatggcta ctgacgccgt ccaaacctat tgtcgact                    48


<210>  146
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 582-39

<400>  146
acagcttagc ataatggcta ctgacgccgt ccaaacctat ttacgact                    48


<210>  147
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-1

<400>  147
acaggtcagc ataatgtgct agtgcgcctt caaacctatt tagagact                    48


<210>  148
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-2

<400>  148
acaggtcagc ataatgtgct agtgcgccct caaacctatt tagagact                    48


<210>  149
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-3

<400>  149
acaggttagc ataatgtgct attgcgcctt caaacctatt tagagact                    48


<210>  150
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-4

<400>  150
acaggtcagc ataatgtgct agtgcgcatt caaacctatt tagagact                    48


<210>  151
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-5

<400>  151
acaggttagc ataatgtgct agtgcgcctt caaacctatt ttgagact                    48


<210>  152
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-6

<400>  152
acaggttatc ataatgtgct agtgcgcctt caaacctatt tagagact                    48


<210>  153
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-7

<400>  153
acaggttagc atgatgtgct agtgcgcctt caaacctatt tagagact                    48


<210>  154
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-8

<400>  154
acaggttagc ataatgggct agtgcgcctt caaacctatt tagagact                    48


<210>  155
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-9

<400>  155
acaggtcagc aaaatgtgca agtgcgcctt caaacctatt tagagact                    48


<210>  156
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-10

<400>  156
acaggtcagc ataatgtgct agtgcgcctt caaacctatc tggagact                    48


<210>  157
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-11

<400>  157
acagcttagc ataatgtgct agtgcgcctt caaacctatt tagagact                    48


<210>  158
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-12

<400>  158
acaggtcagc ataatgtgct agtgcgcctt caaacctatt tacagact                    48


<210>  159
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-13

<400>  159
acaggtcagc ataatgtgct agtgcgcctt caaacatatt tagagact                    48


<210>  160
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-14

<400>  160
acagggtagc ataatgtgct agtgcgcctt caaacctatt tagagact                    48


<210>  161
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-15

<400>  161
acaggttagc ataatgtgct agtgcgccct caaacctatt tagagact                    48


<210>  162
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-16

<400>  162
acaggttagc ataatgtgcc agtgcgcctt caaacctatt tagagact                    48


<210>  163
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 769-17

<400>  163
acaggtcagc ataatgggct agtgcgcctt caaacctatt tagagact                    48


<210>  164
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-1

<400>  164
acagcgaagc ataatggcta ctgacgccct caaaccctat ttgcagact                   49


<210>  165
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-2

<400>  165
acagcgaagc ataatggcta ctgacgccct caaaccctat ttacagact                   49


<210>  166
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-3

<400>  166
acagcgaagc ataatggctt ctgacgccct caaaccctat ttgcagact                   49


<210>  167
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-4

<400>  167
acagccaagc atactggcta ctgacgccct caaaccctat ttgcagact                   49


<210>  168
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-5

<400>  168
acagcgaagc ataatggcta ctgacgcccg caaaccctat ttgcagact                   49


<210>  169
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-6

<400>  169
acagcgaagc ataatggcta ctgacggcct caaaccctat ttgcagact                   49


<210>  170
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-7

<400>  170
acagcgaggc ataatggcta ctgacgccct caaaccctat ttgcagact                   49


<210>  171
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-8

<400>  171
acagcgaagc ataatggcta ctgacgcctt caaaccctat ttgcagact                   49


<210>  172
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-9

<400>  172
acagcgaagc ataatggcta cagacgccct caaaacctat ttgcagact                   49


<210>  173
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-10

<400>  173
acagcgaagc ataatggcta ctgacgccct caaaccctat ttgagact                    48


<210>  174
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-11

<400>  174
acagcgaagc ataatggcta ctgacgccct caaaccctat tgtcgact                    48


<210>  175
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-12

<400>  175
acagccaagc ataatggcta ctgacgccct caaaccctat ttgcagact                   49


<210>  176
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-13

<400>  176
acagcgaagc ataatggcta ctgacgccct caaaccctat ttggcgact                   49


<210>  177
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-14

<400>  177
acagcgaagc ataatgtcta ctgacgccct caaaccctat ttgcagact                   49


<210>  178
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-15

<400>  178
acagcgaagc ataatggcta ctgacgccgt caaaccctat ttgtagact                   49


<210>  179
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-16

<400>  179
acagcgaagc ataatggcta ctgacgccct caaaccttat ttgcagact                   49


<210>  180
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-17

<400>  180
acaggtagca taatggctac tgacgccctc aaaccctatt tgcagact                    48


<210>  181
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-18

<400>  181
acagcgaagc ataatggcta ctgacgccct caaaccctat ttctagact                   49


<210>  182
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 795-19

<400>  182
acagcgaagc ataatggcta ctgacgccct caaaccctat ttgtagact                   49


<210>  183
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-1

<400>  183
acagggtagc ataatgggct acttgacgcc ttcacctatt tgtagact                    48


<210>  184
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-2

<400>  184
acagggtagc ataatgggct acttgacgcc ttcacctatt tgagact                     47


<210>  185
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-3

<400>  185
acagggtagc ataatgggct actttacgcc ttcacctatt tgtagact                    48


<210>  186
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-4

<400>  186
acagggtagc ataatgggct acttgacgcc ttcacctatt tctagact                    48


<210>  187
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-5

<400>  187
acagggtagc ataatgggct acttgacgcc ttcacctatt tggagact                    48


<210>  188
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-6

<400>  188
acagggtagc atagtgggct acttgacgcc ttcacctatt tgtagact                    48


<210>  189
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-7

<400>  189
acagggtagc atgatgggct acttgacgcc ttcacctatt tgtagact                    48


<210>  190
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-8

<400>  190
acagggtagc ataatgggct acttgacgcc ttcacctatt agtagact                    48


<210>  191
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-9

<400>  191
acagggtagc ataatgggct atttgacgcc ttcacctatt tgtagact                    48


<210>  192
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-10

<400>  192
acagggtagc ataatgggct acttgccgcc ttcacctatt tgtagact                    48


<210>  193
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-11

<400>  193
acagtgtagc ataattggct acttgacgcc ttcacctatt tgtagact                    48


<210>  194
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-12

<400>  194
acagggtagc ataatgggct acttgacgct ttcacctttt tgtagact                    48


<210>  195
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-13

<400>  195
acagggtagc ataaggggct acttgacgcc ttcacctatt tgtagact                    48


<210>  196
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-14

<400>  196
acagggtagc ataatggact acttgacgcc tccacctatt tgtagact                    48


<210>  197
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 935-15

<400>  197
acagggtagc ataatgggct acttgtcgcc ttcacctatt tgtagact                    48


<210>  198
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-1

<400>  198
acagcgtagc ataatgggct gcagacgccg tcaaacctat ttgcagact                   49


<210>  199
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-2

<400>  199
acagcgtagc ataatgggct gcagacgcag tcaaacctat ttgcagact                   49


<210>  200
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-3

<400>  200
acatgtagca taatgggcta ctgacgccgt caaacctatt tgcagact                    48


<210>  201
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-4

<400>  201
acagcgtagc atagtgggct gcagacgccg tcaaacctat ttgcagact                   49


<210>  202
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-5

<400>  202
acagtgtagc ataatgggct gcagacgcct tcaaacctat ttggagact                   49


<210>  203
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-6

<400>  203
acagtgtagc ataatgggct gctgacgccg tcaaacctat ttgaagact                   49


<210>  204
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-7

<400>  204
acagcgtagc ataatgggct acaggcgccg tcaaacctat ttgcagact                   49


<210>  205
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-8

<400>  205
acagcgtagc ataatgggct actggcgccg tcaaacctat ttgcagact                   49


<210>  206
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-9

<400>  206
acagcgtagc ataatgggct gcagacgccg tcaaacctat ttgagact                    48


<210>  207
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-10

<400>  207
acaggtagca taatgggctg cagacgccgt caaacctatt tgcagact                    48


<210>  208
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-11

<400>  208
acaggtagca taatgggctg ctgacgccgt caaacctatt tacagact                    48


<210>  209
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-12

<400>  209
acagcgtagc atattgggct gcagacgccg tcaaacctat ttgcagact                   49


<210>  210
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-13

<400>  210
acagcgtagc ataatgggct gcagacgcct tcaaacctat ttggagact                   49


<210>  211
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-14

<400>  211
acagtgtagc ataatgggct gcagacgccg tcaaacctat ttgagact                    48


<210>  212
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-15

<400>  212
acagcgtagc ataatgggct gctgacgccg tcaaacctat ttggagact                   49


<210>  213
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-16

<400>  213
acagcgtagc ataatgggct gcagacgccg tcaaacctat ttacagact                   49


<210>  214
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-17

<400>  214
acagcgtagc ataatgggct gctgacgccg tcaaacctat ttgcagact                   49


<210>  215
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-18

<400>  215
acagggtagc ataatgggct gcagacgccg tcaaacctat ttggagact                   49


<210>  216
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-19

<400>  216
acagcgtagc ataatgggct acagacgccg tcaaacctat ttgcagact                   49


<210>  217
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-20

<400>  217
acagcgtcgc ataatgggct gcagacgccg tcaaatctat ttgcagact                   49


<210>  218
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-21

<400>  218
acagcgtagc ataatgggct tcagacgccg tcaaacctat ttgcagact                   49


<210>  219
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 946-22

<400>  219
acatgtagca taatgggctg cagacgccgt caaacctatt tggagact                    48


<210>  220
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 961-1

<400>  220
acaccgtagc ataatgggct actgccgccg tcgacctttt ggagact                     47


<210>  221
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic 996-1

<400>  221
acagggtagc ataatggctt aggacgcctt caaacctatc aagact                      46


<210>  222
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Family 582 Consensus


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n at position 5 can be C, G, or no nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n at position 6 can be A, C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n at position 45 can be A or no nucleotide

<400>  222
acagnntasb dtwvdksmta cygrsgsbgy yywaamyhat kbhbngact                   49


<210>  223
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Family 769 Consensus

<400>  223
acagskyakc awratgkgch aktgcgcmyt caaacmtaty tdsagact                    48


<210>  224
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Family 795 Consensus


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n at position 5 can be C or no nucleotide

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n at position 40 can be T or no nucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n at position 44 can be C, G, T, or no nucleotide

<400>  224
acagnswrgc atamtgkctw cwgacgscbk caaamcytan ttvnmgact                   49


<210>  225
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Family 935 Consensus


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  n at position 43 can be G, T, or no nucleotide

<400>  225
acagkgtcgc atrrkkgrct ayttkhcgcy tycacctwtt wsnagact                    48


<210>  226
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Family 946 Consensus


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n at position 4 can be G or no nucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n at position 5 can be C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n at position 44 can be A, C, G, or no nucleotide

<400>  226
acanngtmgc atadtgggct dcwgrcgcmk tcaaayctat ttrnagact                   49


<210>  227
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Membrane-targeting domain of Src-Flag-Vpx

<400>  227

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Pro 
1               5                   10      


<210>  228
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic Viral protease cleavage domain

<400>  228

Lys Ala Arg Val Leu Ala Glu Ala 
1               5               


<210>  229
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn 
    450                 455             


<210>  230
<211>  723
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic GFP - linker - P2A -IL7Ra IncPPCL codon(exceptP2A) and 
       splice optimized

<400>  230

Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 
65                  70                  75                  80  


Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
                85                  90                  95      


Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Lys 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ser 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile Ser 
        195                 200                 205             


Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser Phe 
    210                 215                 220                 


Ser Ala Cys Cys His Thr His Gly Met Asp Glu Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe 
            260                 265                 270         


Ser Leu Leu Gln Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly 
        275                 280                 285             


Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser 
    290                 295                 300                 


Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu 
305                 310                 315                 320 


Asp Pro Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala 
                325                 330                 335     


Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr 
            340                 345                 350         


Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys 
        355                 360                 365             


Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr 
    370                 375                 380                 


Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg 
385                 390                 395                 400 


Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln 
                405                 410                 415     


Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu 
            420                 425                 430         


Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu 
        435                 440                 445             


Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys 
    450                 455                 460                 


Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp 
465                 470                 475                 480 


Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly 
                485                 490                 495     


Glu Met Asp Pro Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu 
            500                 505                 510         


Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp 
        515                 520                 525             


Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
    530                 535                 540                 


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
545                 550                 555                 560 


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
                565                 570                 575     


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
            580                 585                 590         


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
        595                 600                 605             


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
    610                 615                 620                 


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
625                 630                 635                 640 


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
                645                 650                 655     


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
            660                 665                 670         


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
        675                 680                 685             


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
    690                 695                 700                 


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
705                 710                 715                 720 


Gln Asn Gln 
            


<210>  231
<211>  733
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic GFP - linker - P2A - Myc Tag - IL7Ra IncPPCL 
       codon(exceptP2A) and splice optimized

<400>  231

Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 
65                  70                  75                  80  


Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
                85                  90                  95      


Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Lys 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ser 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile Ser 
        195                 200                 205             


Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser Phe 
    210                 215                 220                 


Ser Ala Cys Cys His Thr His Gly Met Asp Glu Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe 
            260                 265                 270         


Ser Leu Leu Gln Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu 
        275                 280                 285             


Asp Leu Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu 
    290                 295                 300                 


Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly 
305                 310                 315                 320 


Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile 
                325                 330                 335     


Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys 
            340                 345                 350         


Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys 
        355                 360                 365             


Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys 
    370                 375                 380                 


Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu 
385                 390                 395                 400 


Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe 
                405                 410                 415     


Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val 
            420                 425                 430         


Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp 
        435                 440                 445             


Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys 
    450                 455                 460                 


Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp 
465                 470                 475                 480 


His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe 
                485                 490                 495     


Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu 
            500                 505                 510         


Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala 
        515                 520                 525             


Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro 
    530                 535                 540                 


Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu 
545                 550                 555                 560 


Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser 
                565                 570                 575     


Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp 
            580                 585                 590         


Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu 
        595                 600                 605             


Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro 
    610                 615                 620                 


Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu 
                645                 650                 655     


Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
            660                 665                 670         


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
        675                 680                 685             


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
    690                 695                 700                 


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
705                 710                 715                 720 


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                725                 730             


<210>  232
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic GFP - linker - P2A - IL7RaSP - Myc Tag - IL7RaIncPPCL 
       C-terminal truncation codon(exceptP2A) and splice

<400>  232

Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 
65                  70                  75                  80  


Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
                85                  90                  95      


Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Lys 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ser 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile Ser 
        195                 200                 205             


Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser Phe 
    210                 215                 220                 


Ser Ala Cys Cys His Thr His Gly Met Asp Glu Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe 
            260                 265                 270         


Ser Leu Leu Gln Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu 
        275                 280                 285             


Asp Leu Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu 
    290                 295                 300                 


Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly 
305                 310                 315                 320 


Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile 
                325                 330                 335     


Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys 
            340                 345                 350         


Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys 
        355                 360                 365             


Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys 
    370                 375                 380                 


Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu 
385                 390                 395                 400 


Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe 
                405                 410                 415     


Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val 
            420                 425                 430         


Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp 
        435                 440                 445             


Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys 
    450                 455                 460                 


Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp 
465                 470                 475                 480 


His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe 
                485                 490                 495     


Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu 
            500                 505                 510         


Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala 
        515                 520                 525             


Leu Leu Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro 
    530                 535                 540                 


Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu 
545                 550                 555                 560 


Cys Lys Lys Pro Arg Lys Val Ser Val Phe Gly Ala 
                565                 570         


<210>  233
<211>  562
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic GFP - linker - P2A - IL7RaSP - IL7RaIncPPCL C-terminal 
       truncation codon(exceptP2A) and splice optimized

<400>  233

Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 
65                  70                  75                  80  


Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
                85                  90                  95      


Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Lys 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ser 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile Ser 
        195                 200                 205             


Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser Phe 
    210                 215                 220                 


Ser Ala Cys Cys His Thr His Gly Met Asp Glu Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe 
            260                 265                 270         


Ser Leu Leu Gln Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly 
        275                 280                 285             


Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser 
    290                 295                 300                 


Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu 
305                 310                 315                 320 


Asp Pro Asp Val Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala 
                325                 330                 335     


Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr 
            340                 345                 350         


Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys 
        355                 360                 365             


Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr 
    370                 375                 380                 


Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg 
385                 390                 395                 400 


Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln 
                405                 410                 415     


Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu 
            420                 425                 430         


Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu 
        435                 440                 445             


Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys 
    450                 455                 460                 


Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp 
465                 470                 475                 480 


Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly 
                485                 490                 495     


Glu Met Asp Pro Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu 
            500                 505                 510         


Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp 
        515                 520                 525             


Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
    530                 535                 540                 


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Val Ser Val Phe 
545                 550                 555                 560 


Gly Ala 
        


<210>  234
<211>  824
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic GFP - linker - P2A - eTag -  IL7RaIncPPCL N-terminal 
       deletion codon(exceptP2A) and splice optimized

<400>  234

Met Ser Gly Gly Glu Glu Leu Phe Ala Gly Ile Val Pro Val Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val His Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Asp Tyr Gly Lys Leu Glu Ile Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Cys Tyr Gly Ile Gln Cys Phe Ala Arg Tyr Pro Glu His Met Lys Met 
65                  70                  75                  80  


Asn Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
                85                  90                  95      


Thr Ile Gln Phe Gln Asp Asp Gly Lys Tyr Lys Thr Arg Gly Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Lys 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Ser 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Arg Pro Asp Lys Ala Asn Asn Gly 
145                 150                 155                 160 


Leu Glu Ala Asn Phe Lys Thr Arg His Asn Ile Glu Gly Gly Gly Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Thr Asn Val Pro Leu Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Ile Pro Ile Asn His Tyr Leu Ser Thr Gln Thr Lys Ile Ser 
        195                 200                 205             


Lys Asp Arg Asn Glu Ala Arg Asp His Met Val Leu Leu Glu Ser Phe 
    210                 215                 220                 


Ser Ala Cys Cys His Thr His Gly Met Asp Glu Leu Tyr Arg Gly Ser 
225                 230                 235                 240 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
            260                 265                 270         


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
        275                 280                 285             


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
    290                 295                 300                 


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
305                 310                 315                 320 


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
                325                 330                 335     


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
            340                 345                 350         


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
        355                 360                 365             


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
    370                 375                 380                 


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
385                 390                 395                 400 


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
                405                 410                 415     


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
            420                 425                 430         


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
        435                 440                 445             


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
    450                 455                 460                 


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
465                 470                 475                 480 


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
                485                 490                 495     


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
            500                 505                 510         


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
        515                 520                 525             


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
    530                 535                 540                 


Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala 
545                 550                 555                 560 


Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly 
                565                 570                 575     


Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Glu Ile 
            580                 585                 590         


Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Pro Pro Cys Leu 
        595                 600                 605             


Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu 
    610                 615                 620                 


Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser 
625                 630                 635                 640 


Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg 
                645                 650                 655     


Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln 
            660                 665                 670         


Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe 
        675                 680                 685             


Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg 
    690                 695                 700                 


Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val 
705                 710                 715                 720 


Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala 
                725                 730                 735     


Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser 
            740                 745                 750         


Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp 
        755                 760                 765             


Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe 
    770                 775                 780                 


Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln 
785                 790                 795                 800 


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
                805                 810                 815     


Met Ser Ser Phe Tyr Gln Asn Gln 
            820                 


<210>  235
<211>  593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic MV(ed)-HD24

<400>  235

Met Asn Arg Glu His Leu Met Ile Asp Arg Pro Tyr Val Leu Leu Ala 
1               5                   10                  15      


Val Leu Phe Val Met Ser Leu Ser Leu Ile Gly Leu Leu Ala Ile Ala 
            20                  25                  30          


Gly Ile Arg Leu His Arg Ala Ala Ile Tyr Thr Ala Glu Ile His Lys 
        35                  40                  45              


Ser Leu Ser Thr Asn Leu Asp Val Thr Asn Ser Ile Glu His Gln Val 
    50                  55                  60                  


Lys Asp Val Leu Thr Pro Leu Phe Lys Ile Ile Gly Asp Glu Val Gly 
65                  70                  75                  80  


Leu Arg Thr Pro Gln Arg Phe Thr Asp Leu Val Lys Phe Ile Ser Asp 
                85                  90                  95      


Lys Ile Lys Phe Leu Asn Pro Asp Arg Glu Tyr Asp Phe Arg Asp Leu 
            100                 105                 110         


Thr Trp Cys Ile Asn Pro Pro Glu Arg Ile Lys Leu Asp Tyr Asp Gln 
        115                 120                 125             


Tyr Cys Ala Asp Val Ala Ala Glu Glu Leu Met Asn Ala Leu Val Asn 
    130                 135                 140                 


Ser Thr Leu Leu Glu Thr Arg Thr Thr Asn Gln Phe Leu Ala Val Ser 
145                 150                 155                 160 


Lys Gly Asn Cys Ser Gly Pro Thr Thr Ile Arg Gly Gln Phe Ser Asn 
                165                 170                 175     


Met Ser Leu Ser Leu Leu Asp Leu Tyr Leu Ser Arg Gly Tyr Asn Val 
            180                 185                 190         


Ser Ser Ile Val Thr Met Thr Ser Gln Gly Met Tyr Gly Gly Thr Tyr 
        195                 200                 205             


Leu Val Glu Lys Pro Asn Leu Ser Ser Lys Arg Ser Glu Leu Ser Gln 
    210                 215                 220                 


Leu Ser Met Tyr Arg Val Phe Glu Val Gly Val Ile Arg Asn Pro Gly 
225                 230                 235                 240 


Leu Gly Ala Pro Val Phe His Met Thr Asn Tyr Leu Glu Gln Pro Val 
                245                 250                 255     


Ser Asn Asp Leu Ser Asn Cys Met Val Ala Leu Gly Glu Leu Lys Leu 
            260                 265                 270         


Ala Ala Leu Cys His Gly Glu Asp Ser Ile Thr Ile Pro Tyr Gln Gly 
        275                 280                 285             


Ser Gly Lys Gly Val Ser Phe Gln Leu Val Lys Leu Gly Val Trp Lys 
    290                 295                 300                 


Ser Pro Thr Asp Met Gln Ser Trp Val Pro Leu Ser Thr Asp Asp Pro 
305                 310                 315                 320 


Val Ile Asp Arg Leu Tyr Leu Ser Ser His Arg Gly Val Ile Ala Asp 
                325                 330                 335     


Asn Gln Ala Lys Trp Ala Val Pro Thr Thr Arg Thr Asp Asp Lys Leu 
            340                 345                 350         


Arg Met Glu Thr Cys Phe Gln Gln Ala Cys Lys Gly Lys Ile Gln Ala 
        355                 360                 365             


Leu Cys Glu Asn Pro Glu Trp Ala Pro Leu Lys Asp Asn Arg Ile Pro 
    370                 375                 380                 


Ser Tyr Gly Val Leu Ser Val Asp Leu Ser Leu Thr Val Glu Leu Lys 
385                 390                 395                 400 


Ile Lys Ile Ala Ser Gly Phe Gly Pro Leu Ile Thr His Gly Ser Gly 
                405                 410                 415     


Met Asp Leu Tyr Lys Ser Asn His Asn Asn Val Tyr Trp Leu Thr Ile 
            420                 425                 430         


Pro Pro Met Lys Asn Leu Ala Leu Gly Val Ile Asn Thr Leu Glu Trp 
        435                 440                 445             


Ile Pro Arg Phe Lys Val Ser Pro Asn Leu Phe Thr Val Pro Ile Lys 
    450                 455                 460                 


Glu Ala Gly Glu Asp Cys His Ala Pro Thr Tyr Leu Pro Ala Glu Val 
465                 470                 475                 480 


Asp Gly Asp Val Lys Leu Ser Ser Asn Leu Val Ile Leu Pro Gly Gln 
                485                 490                 495     


Asp Leu Gln Tyr Val Leu Ala Thr Tyr Asp Thr Ser Arg Val Glu His 
            500                 505                 510         


Ala Val Val Tyr Tyr Val Tyr Ser Pro Gly Arg Ser Phe Ser Tyr Phe 
        515                 520                 525             


Tyr Pro Phe Arg Leu Pro Ile Lys Gly Val Pro Ile Glu Leu Gln Val 
    530                 535                 540                 


Glu Cys Phe Thr Trp Asp Gln Lys Leu Trp Cys Arg His Phe Cys Val 
545                 550                 555                 560 


Leu Ala Asp Ser Glu Ser Gly Gly His Ile Thr His Ser Gly Met Val 
                565                 570                 575     


Gly Met Gly Val Ser Cys Thr Val Thr Arg Glu Asp Gly Thr Asn Arg 
            580                 585                 590         


Arg 
    


<210>  236
<211>  1275
<212>  DNA
<213>  Mesoplasma florum

<400>  236
aaaaaaaata aaatcaatag caaatattaa gatttttaag aaataaaaaa ttaatattaa       60

tttacaactg aatataaaag aaacttatac agggtagcat aatgggctac tgaccccgcc      120

ttcaaaccta tttggagact ataagtgaaa aaccactctt taattattaa agtttctttt      180

tatgtccaaa agacaagaag aaactttttt atttagttga atttataata agagaaaaag      240

aaaggatatt atatggcaaa aataaaaaac caatattaca acgagtctgt ttcgccaatt      300

gaatatgcgc aacaaggatt taaaggaaaa atgcgttcag taaactgaaa cgtagtaaat      360

gatgaaaaag atttagaggt atgaaataga attacacaaa acttctgatt gcctgaaaaa      420

attccagttt caaatgattt aacttcatga agaactttga caccagaatg acaagaatta      480

attacaagaa cttttacagg attaacattg ttagatacaa ttcaagctac tgttggtgat      540

gtggctcaag ttcctaactc attaactgac catgaacaag taatttacac aaactttgca      600

tttatggttg cagttcacgc tagatcatat ggttcaatct tttcaacttt atgttcaagt      660

gaacaaattg aagaggctca tgaatgagtt atcaatacag aaacattaca agaaagagct      720

aaagcattaa ttccttatta tgtgaatgat gaccctttaa agtcaaaagt tgcagctgct      780

ttaatgccag gcttcttatt atatggaggc ttctatttac cattttacct atcagctaga      840

ggtaaattac caaacacttc agatattatt agattaatat taagagataa agttatacat      900

aactactata gtggttataa atatcaaaag aaagttgcta aactttctcc agaaaaacaa      960

gctgaaatga aagaatttgt ttttaaatta ttatatgaat taatagattt agaaaaagct     1020

tatttgaaag aattgtatga ggattttgga ttagctgatg atgctattag atttagtgtt     1080

tacaacgcag gtaaattttt acaaaattta ggttatgatt caccgtttac agaagaagaa     1140

acaagaattg agccagaaat attcacacaa ttatcagcta gagctgatga aaaccatgat     1200

ttcttttcag ggaatggctc atcatatatt atgggagttt cagaagaaac tgaagatgac     1260

gattgggagt tttaa                                                      1275


<210>  237
<211>  64
<212>  RNA
<213>  Mesoplasma florum

<400>  237
acuuauacag gguagcauaa ugggcuacug accccgccuu caaaccuauu uggagacuau       60

aagu                                                                    64


<210>  238
<211>  69
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Deoxyguanosine riboswitch aptamer mutations


<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  n at positions 10-13 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (27)..(29)
<223>  n at positions 27-29 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n at positions 31-32 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (33)..(40)
<223>  n at positions 33-40 can be A, C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (44)..(46)
<223>  n at positions 44-46 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (57)..(59)
<223>  n at positions 57-59 can be A, C, G, or T

<400>  238
acuuauacan nnnagcauaa ugggcunnng nnnnnnnnnn gccnnnaaac cuauuunnng       60

acuauaagu                                                               69


<210>  239
<211>  84
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo library for screen


<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n at positions 19-21 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (32)..(34)
<223>  n at positions 32-34 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  n at positions 38-39 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (40)..(47)
<223>  n at positions 40-47 can be A, C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n at positions 49-51 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (65)..(68)
<223>  n at positions 65-68 can be A, C, G, or T

<400>  239
cgcgcgacac ttatagtcnn naaataggtt tnnnggcnnn nnnnnnncnn nagcccatta       60

tgctnnnntg tataagtgcc gccc                                              84


<210>  240
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic T7 promoter amplification primer

<400>  240
taatacgact cactataggg cggcacttat aca                                    33


<210>  241
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Reverse amplification primer

<400>  241
cgcgcgacac ttatagtc                                                     18


<210>  242
<211>  915
<212>  DNA
<213>  Bacillus subtilis

<400>  242
tcaaaagcct ggcggcgcgg tcgtcagact cttttatatc gaatcccctt gaaatacgaa       60

tgatatctaa aaaaacaaaa ttaaagttcg ggaattttta ttttcagcct atgcaagaga      120

ttagaatctt gatataattt attacaatat aataggaaca ctcatataat cgcgtggata      180

tggcacgcaa gtttctaccg ggcaccgtaa atgtccgact atgggtgagc aatggaaccg      240

cacgtgtacg gttttttgtg atatcagcat tgcttgctct ttatttgagc gggcaatgct      300

ttttttattc tcataacgga ggtagacagg atggaagcac tgaaacggaa aatagaggaa      360

gaaggcgtcg tattatctga tcaggtattg aaagtggatt cttttttgaa tcaccaaatt      420

gatccgctgc ttatgcagag aattggtgat gaatttgcgt ctaggtttgc aaaagacggt      480

attaccaaaa ttgtgacaat cgaatcatca ggtatcgctc ccgctgtaat gacgggcttg      540

aagctgggtg tgccagttgt cttcgcgaga aagcataaat cgttaacact caccgacaac      600

ttgctgacag cgtctgttta ttcctttacg aagcaaacag aaagccaaat cgcagtgtct      660

gggacccacc tgtcggatca ggatcatgtg ctgattatcg atgatttttt ggcaaatgga      720

caggcagcgc acgggcttgt gtcgattgtg aagcaagcgg gagcttctat tgcgggaatc      780

ggcattgtta ttgaaaagtc atttcagccg ggaagagatg aacttgtaaa actgggctac      840

cgagtggaat ctttggcaag aattcagtct ttagaagaag gaaaagtgtc cttcgtacag      900

gaggttcatt catga                                                       915


<210>  243
<211>  69
<212>  RNA
<213>  Bacillus subtilis

<400>  243
cacucauaua aucgcgugga uauggcacgc aaguuucuac cgggcaccgu aaauguccga       60

cuaugggug                                                               69


<210>  244
<211>  74
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Guanosine xpt riboswitch aptamer mutations


<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  n at positions 11-14 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (30)..(35)
<223>  n at positions 30-35 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (36)..(43)
<223>  n at positions 36-43 can be A, C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (47)..(49)
<223>  n at positions 47-49 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n at positions 61-63 can be A, C, G, or T

<400>  244
cacucauaua nnnncgugga uauggcacgn nngnnnnnnn nnnaccnnnu accguaaaug       60

nnngacuaug ggug                                                         74


<210>  245
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo library for screen


<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  n at positions 20-22 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  n at positions 34-36 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n at positions 40-41 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (42)..(49)
<223>  n at positions 42-49 can be A, C, G, T, or no nucleotide

<220>
<221>  misc_feature
<222>  (51)..(53)
<223>  n at positions 51-53 can be A, C, G, or T

<220>
<221>  misc_feature
<222>  (69)..(72)
<223>  n at positions 69-72 can be A, C, G, or T

<400>  245
cgcgcgacca cccatagtcn nncatttacg gtgnnnggtn nnnnnnnnnc nnncgtgcca       60

tatccacgnn nntatatgag tggccgccc                                         89


<210>  246
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic T7 promoter amplification primer

<400>  246
taatacgact cactataggg cggccactca tata                                   34


<210>  247
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Reverse amplification primer

<400>  247
cgcgcgacca cccatagtc                                                    19


<210>  248
<211>  152
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo 1 Transcribed RNA

<400>  248
gggcggcacu uauacagggu agcauaaugg gcuacugacg ccuucaaacc uauuuggaga       60

cuauaagugu cgcgcggggc ggcacuuaua caggguagca uaaugggcua cugacgccuu      120

caaaccuauu uggagacuau aagugucgcg cg                                    152


<210>  249
<211>  76
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo 1 Synthesized template

<400>  249
cgcgcgacac ttatagtctc caaataggtt tgaaggcgtc agtagcccat tatgctaccc       60

tgtataagtg ccgccc                                                       76


<210>  250
<211>  79
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo 2 Transcribed RNA

<400>  250
gggcggcacu uauacagggu agcauaaugg gcuacugacc ccgccuucaa accuauuugg       60

agacuauaag ugucgcgcg                                                    79


<210>  251
<211>  79
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic Oligo 2 Synthesized template

<400>  251
cgcgcgacac ttatagtctc caaataggtt tgaaggcggg gtcagtagcc cattatgcta       60

ccctgtataa gtgccgccc                                                    79


<210>  252
<211>  560
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic DAFss-aCD3scFv(UCHT1)IgG1 Fc-CD14GPI

<400>  252

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Asp Ile 
            20                  25                  30          


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        35                  40                  45              


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
    50                  55                  60                  


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr 
65                  70                  75                  80  


Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            100                 105                 110         


Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe 
        115                 120                 125             


Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly 
        195                 200                 205             


Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val 
    210                 215                 220                 


Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp 
                245                 250                 255     


Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    370                 375                 380                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Val Asp Asn Leu Thr Leu Asp 
            500                 505                 510         


Gly Asn Pro Phe Leu Val Pro Gly Thr Ala Leu Pro His Glu Gly Ser 
        515                 520                 525             


Met Asn Ser Gly Val Val Pro Ala Cys Ala Arg Ser Thr Leu Ser Val 
    530                 535                 540                 


Gly Val Ser Gly Thr Leu Val Leu Leu Gln Gly Ala Arg Gly Phe Ala 
545                 550                 555                 560 


<210>  253
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic DAFss-CD80ECD-CD16GPI

<400>  253

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Val Ile 
            20                  25                  30          


His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His 
        35                  40                  45              


Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys 
    50                  55                  60                  


Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp 
65                  70                  75                  80  


Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser 
                85                  90                  95      


Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys 
            100                 105                 110         


Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala 
        115                 120                 125             


Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser 
    130                 135                 140                 


Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly Glu 
                165                 170                 175     


Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr Glu 
            180                 185                 190         


Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn His 
        195                 200                 205             


Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln Thr 
    210                 215                 220                 


Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn Val Ser 
225                 230                 235                 240 


Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu 
                245                 250                 255     


Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val 
            260                 265                 270         


Lys Thr Asn Ile 
        275     


<210>  254
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic DAFss-IL7-DAF

<400>  254

Met Ala Thr Thr Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu 
1               5                   10                  15      


Pro Leu Leu Gly Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys 
            20                  25                  30          


Leu Pro Ala Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
        35                  40                  45              


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
    50                  55                  60                  


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
65                  70                  75                  80  


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
                85                  90                  95      


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
            100                 105                 110         


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
        115                 120                 125             


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
    130                 135                 140                 


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
145                 150                 155                 160 


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
                165                 170                 175     


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Cys Gly Leu Pro Pro 
            180                 185                 190         


Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro 
        195                 200                 205             


Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile 
    210                 215                 220                 


Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp Ser 
225                 230                 235                 240 


Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg Leu 
                245                 250                 255     


Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro 
            260                 265                 270         


Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu 
        275                 280                 285             


Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser 
    290                 295                 300                 


Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu 
305                 310                 315                 320 


Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly Ala 
                325                 330                 335     


Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr 
            340                 345                 350         


Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp Pro 
        355                 360                 365             


Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp 
    370                 375                 380                 


Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser 
385                 390                 395                 400 


Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser 
                405                 410                 415     


Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro 
            420                 425                 430         


Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val 
        435                 440                 445             


Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr 
    450                 455                 460                 


Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr 
465                 470                 475                 480 


Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr 
                485                 490                 495     


Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser 
            500                 505                 510         


Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr 
        515                 520                 525             


Met Gly Leu Leu Thr 
    530             


<210>  255
<211>  1823
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic EF-1a promoter with miRs

<400>  255
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg      360

gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg      420

cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct      480

ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg      540

caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt ttttggggcc      600

gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga      660

gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc tctggtgcct      720

ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca      780

gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg      840

acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg      900

tcctcagccg tcgcttcatg tgactccact gagtaccggg cgccgtccag gcacctcgat      960

tagttcctgg aggcttgctg aaggctgtat gctgacatgg tacagttcaa tggtggtttt     1020

ggccactgac tgaccaccat tgctgtacca tgtcaggaca caaggcctgt tactagcact     1080

cacatggaac aaatggccca cattggtgcc ggatgaagct cttatgttgc acggtcatct     1140

ggaggcttgc tgaaggctgt atgctgtcag tctgttcatc ttctggcgtt ttggccactg     1200

actgacgcca gaaggaacag actgacagga cacaaggcct gttactagca ctcacatgga     1260

acaaatggcc gttgccggag tcttggcagc gagagatcac tatcaactaa ctggaggctt     1320

gctgaaggct gtatgctgaa gcgtgaagtg aatcaacggg ttttggccac tgactgaccc     1380

gttgatactt cacgcttcag gacacaaggc ctgttactag cactcacatg gaacaaatgg     1440

ccgtgttaat tgtccatgta gcgaggcatc cttatggcgt ggctggaggc ttgctgaagg     1500

ctgtatgctg gcagtatcct agtacattga cgttttggcc actgactgac gtcaatgtta     1560

ggatactgcc aggacacaag gcctgttact agcactcaca tggaacaaat ggccgctttt     1620

ggagtacgtc gtctttaggt tggggggagg ggttttatgc gatggagttt ccccacactg     1680

agtgggtgga gactgaagtt aggccagctt ggcacttgat gtaattctcc ttggaatttg     1740

ccctttttga gtttggatct tggttcattc tcaagcctca gacagtggtt caaagttttt     1800

ttcttccatt tcaggtgtcg tga                                             1823


<210>  256
<211>  28
<212>  DNA
<213>  Mus musculus

<400>  256
ctggaggctt gctgaaggct gtatgctg                                          28


<210>  257
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  257
acatggtaca gttcaatggt g                                                 21


<210>  258
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding loop

<400>  258
gttttggcca ctgactgac                                                    19


<210>  259
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding stem

<400>  259
caccattgct gtaccatgt                                                    19


<210>  260
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  260
caggacacaa ggcctgttac tagcactcac atggaacaaa tggcc                       45


<210>  261
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  261
tcagtctgtt catcttctgg c                                                 21


<210>  262
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  262
gccagaagga acagactga                                                    19


<210>  263
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  263
aagcgtgaag tgaatcaacg g                                                 21


<210>  264
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  264
ccgttgatac ttcacgctt                                                    19


<210>  265
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  265
gcagtatcct agtacattga c                                                 21


<210>  266
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  266
gtcaatgtta ggatactgc                                                    19


<210>  267
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  267
atatgtactt ggctggacag c                                                 21


<210>  268
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  268
gctgtccaca agtacatat                                                    19


<210>  269
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding linker

<400>  269
cacattggtg ccggatgaag ctcttatgtt gccggtcat                              39


<210>  270
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  270
ctgttaatgc taatcgtgat a                                                 21


<210>  271
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  271
tatcacgatt attaacag                                                     18


<210>  272
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding linker

<400>  272
gttgccggag tcttggcagc gagagatcac tatcaactaa                             40


<210>  273
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  273
taccagttta gcacgaagct c                                                 21


<210>  274
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  274
gagcttcgct aaactggta                                                    19


<210>  275
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic DNA encoding linker

<400>  275
gtgttaattg tccatgtagc gaggcatcct tatggcgtgg                             40


<210>  276
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  276
tgccgctgaa atccaaggca a                                                 21


<210>  277
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA encoding MiRNA stem

<400>  277
ttgccttgtt tcagcggca                                                    19


<210>  278
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic UCHT1scFvFc-GPI

<400>  278

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
                165                 170                 175     


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Thr Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu 
            500                 505                 510         


Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val 
        515                 520                 525             


Thr Met Gly Leu Leu Thr 
    530                 


<210>  279
<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic OKT3scFvFc-GPI

<400>  279

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
                165                 170                 175     


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Leu Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Pro Asn Lys 
                485                 490                 495     


Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr 
            500                 505                 510         


Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu 
        515                 520                 525             


Leu Thr 
    530 


<210>  280
<211>  280
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic hCD80-CD16 GPI

<400>  280

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val 
                245                 250                 255     


Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu 
            260                 265                 270         


Tyr Phe Ser Val Lys Thr Asn Ile 
        275                 280 


<210>  281
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Target 1 MRB VH

<400>  281

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  282
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Target 1 MRB VL

<400>  282

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  283
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 1

<400>  283

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  284
<211>  357
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic C1 control polypeptide containing GMCSF alpha chain 
       signal sequence (amino acids 1-22) and eTAG (amino acids 23-357)

<400>  284

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  285
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic OKT3 ScFv

<400>  285

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


<210>  286
<211>  532
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic DAFss-IL7-DAF fusion

<400>  286

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
        35                  40                  45              


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
    50                  55                  60                  


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
65                  70                  75                  80  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
                85                  90                  95      


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
            100                 105                 110         


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
        115                 120                 125             


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
    130                 135                 140                 


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
145                 150                 155                 160 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
                165                 170                 175     


Asn Lys Ile Leu Met Gly Thr Lys Glu His Cys Gly Leu Pro Pro Asp 
            180                 185                 190         


Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu 
        195                 200                 205             


Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile Pro 
    210                 215                 220                 


Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp 
225                 230                 235                 240 


Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg Leu Asn 
                245                 250                 255     


Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val 
            260                 265                 270         


Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro 
        275                 280                 285             


Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr 
    290                 295                 300                 


Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile 
305                 310                 315                 320 


Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr 
                325                 330                 335     


Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser 
            340                 345                 350         


Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu 
        355                 360                 365             


Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn 
    370                 375                 380                 


Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val 
385                 390                 395                 400 


Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile 
                405                 410                 415     


Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro 
            420                 425                 430         


Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val Gln 
        435                 440                 445             


Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr Ser 
    450                 455                 460                 


Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg 
465                 470                 475                 480 


Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr Pro 
                485                 490                 495     


Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly 
            500                 505                 510         


His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met 
        515                 520                 525             


Gly Leu Leu Thr 
    530         


<210>  287
<211>  564
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic DAFss-aCD3scFv(UCHT1)IgG1 Fc-CD14GPI

<400>  287

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        35                  40                  45              


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg 
    50                  55                  60                  


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
65                  70                  75                  80  


Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe 
                85                  90                  95      


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
            100                 105                 110         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu 
        115                 120                 125             


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp 
            180                 185                 190         


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn 
        195                 200                 205             


Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
    210                 215                 220                 


Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly 
                245                 250                 255     


Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        275                 280                 285             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    290                 295                 300                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
305                 310                 315                 320 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                325                 330                 335     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            340                 345                 350         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        355                 360                 365             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    370                 375                 380                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
385                 390                 395                 400 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                405                 410                 415     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Val Asp Asn 
            500                 505                 510         


Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr Ala Leu Pro 
        515                 520                 525             


His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys Ala Arg Ser 
    530                 535                 540                 


Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu Gln Gly Ala 
545                 550                 555                 560 


Arg Gly Phe Ala 
                


<210>  288
<211>  280
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic DAFss-CD80ECD-CD16GPI

<400>  288

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val 
                245                 250                 255     


Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu 
            260                 265                 270         


Tyr Phe Ser Val Lys Thr Asn Ile 
        275                 280 


<210>  289
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Target 2 MRB VH

<400>  289

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  290
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Target 2 MRB VL

<400>  290

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  291
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker2

<400>  291

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  292
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M001

<400>  292

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Glu Ile Asn Asn Ser Ser 
                325                 330                 335     


Gly Glu Met Asp Pro Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile 
            340                 345                 350         


Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu 
        355                 360                 365             


<210>  293
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M002

<400>  293

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu 
        195                 200                 205             


Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
    210                 215                 220                 


Leu Val Ile Leu Ala Cys Val Leu 
225                 230         


<210>  294
<211>  194
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M007

<400>  294

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu His Asp Leu Glu 
1               5                   10                  15      


Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro Arg Gly Pro Pro Leu Ser 
            20                  25                  30          


Ser Ser Leu Gly Leu Ala Leu Leu Leu Leu Leu Leu Ala Leu Leu Phe 
        35                  40                  45              


Trp Leu Tyr Ile Val Met Ser Asp Trp Thr Gly Gly Ala Leu Leu Val 
    50                  55                  60                  


Leu Tyr Ser Phe Ala Leu Met Leu Ile Ile Ile Ile Leu Ile Ile Phe 
65                  70                  75                  80  


Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu Gly Ala Leu Cys Ile Leu 
                85                  90                  95      


Leu Leu Met Ile Thr Leu Leu Leu Ile Ala Leu Trp Asn Leu His Gly 
            100                 105                 110         


Gln Ala Leu Phe Leu Gly Ile Val Leu Phe Ile Phe Gly Cys Leu Leu 
        115                 120                 125             


Val Leu Gly Ile Trp Ile Tyr Leu Leu Glu Met Leu Trp Arg Leu Gly 
    130                 135                 140                 


Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe Leu Ala Phe Phe Leu Asp 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu Gln Gln Asn Trp Trp Thr 
                165                 170                 175     


Leu Leu Val Asp Leu Leu Trp Leu Leu Leu Phe Leu Ala Ile Leu Ile 
            180                 185                 190         


Trp Met 
        


<210>  295
<211>  174
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M008

<400>  295

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Ser Ser Leu Gly 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile 
            20                  25                  30          


Val Met Ser Asp Trp Thr Gly Gly Ala Leu Leu Val Leu Tyr Ser Phe 
        35                  40                  45              


Ala Leu Met Leu Ile Ile Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg 
    50                  55                  60                  


Asp Leu Leu Cys Pro Leu Gly Ala Leu Cys Ile Leu Leu Leu Met Ile 
65                  70                  75                  80  


Thr Leu Leu Leu Ile Ala Leu Trp Asn Leu His Gly Gln Ala Leu Phe 
                85                  90                  95      


Leu Gly Ile Val Leu Phe Ile Phe Gly Cys Leu Leu Val Leu Gly Ile 
            100                 105                 110         


Trp Ile Tyr Leu Leu Glu Met Leu Trp Arg Leu Gly Ala Thr Ile Trp 
        115                 120                 125             


Gln Leu Leu Ala Phe Phe Leu Ala Phe Phe Leu Asp Leu Ile Leu Leu 
    130                 135                 140                 


Ile Ile Ala Leu Tyr Leu Gln Gln Asn Trp Trp Thr Leu Leu Val Asp 
145                 150                 155                 160 


Leu Leu Trp Leu Leu Leu Phe Leu Ala Ile Leu Ile Trp Met 
                165                 170                 


<210>  296
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M009

<400>  296

Met Glu His Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Leu Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Val Met Ser Asp Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ser Phe Ala Leu Met Leu Ile Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Ile Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Phe Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Ile Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Met Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met 
            180                 


<210>  297
<211>  162
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M010

<400>  297

Met Ser Leu Gly Leu Ala Leu Leu Leu Leu Leu Leu Ala Leu Leu Phe 
1               5                   10                  15      


Trp Leu Tyr Ile Val Met Ser Asp Trp Thr Gly Gly Ala Leu Leu Val 
            20                  25                  30          


Leu Tyr Ser Phe Ala Leu Met Leu Ile Ile Ile Ile Leu Ile Ile Phe 
        35                  40                  45              


Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu Gly Ala Leu Cys Ile Leu 
    50                  55                  60                  


Leu Leu Met Ile Thr Leu Leu Leu Ile Ala Leu Trp Asn Leu His Gly 
65                  70                  75                  80  


Gln Ala Leu Phe Leu Gly Ile Val Leu Phe Ile Phe Gly Cys Leu Leu 
                85                  90                  95      


Val Leu Gly Ile Trp Ile Tyr Leu Leu Glu Met Leu Trp Arg Leu Gly 
            100                 105                 110         


Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe Leu Ala Phe Phe Leu Asp 
        115                 120                 125             


Leu Ile Leu Leu Ile Ile Ala Leu Tyr Leu Gln Gln Asn Trp Trp Thr 
    130                 135                 140                 


Leu Leu Val Asp Leu Leu Trp Leu Leu Leu Phe Leu Ala Ile Leu Ile 
145                 150                 155                 160 


Trp Met 
        


<210>  298
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M012

<400>  298

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Ala Glu Thr Pro Thr Pro Pro 
                325                 330                 335     


Lys Pro Lys Leu Ser Lys Cys Ile Leu Ile Ser Ser Leu Ala Ile Leu 
            340                 345                 350         


Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp 
        355                 360             


<210>  299
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M013

<400>  299

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Ala Glu Thr Pro Thr Pro Pro Lys Pro Lys Leu Ser Lys Cys Ile 
        195                 200                 205             


Leu Ile Ser Ser Leu Ala Ile Leu Leu Met Val Ser Leu Leu Leu Leu 
    210                 215                 220                 


Ser Leu Trp 
225         


<210>  300
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M018

<400>  300

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Thr Glu Ser Val Leu Pro Met 
                325                 330                 335     


Trp Val Leu Ala Leu Ile Glu Ile Phe Leu Thr Ile Ala Val Leu Leu 
            340                 345                 350         


Ala Leu 
        


<210>  301
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M019

<400>  301

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile Glu Ile 
        195                 200                 205             


Phe Leu Thr Ile Ala Val Leu Leu Ala Leu 
    210                 215             


<210>  302
<211>  360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M024

<400>  302

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Thr Pro Glu Gly Ser Glu Leu 
                325                 330                 335     


His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Asn Cys Leu 
            340                 345                 350         


Cys Gly Thr Ala Trp Leu Cys Cys 
        355                 360 


<210>  303
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M025

<400>  303

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Thr Pro Glu Gly Ser Glu Leu His Ile Ile Leu Gly Leu Phe Gly 
        195                 200                 205             


Leu Leu Leu Leu Leu Asn Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys 
    210                 215                 220                 


<210>  304
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M030

<400>  304

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Thr Pro Ser Asp Leu Asp Pro 
                325                 330                 335     


Cys Cys Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu 
            340                 345                 350         


Thr Val Leu Ala Leu Leu Ser 
        355                 


<210>  305
<211>  223
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M031

<400>  305

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Thr Pro Ser Asp Leu Asp Pro Cys Cys Leu Thr Leu Ser Leu Ile 
        195                 200                 205             


Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu Ser 
    210                 215                 220             


<210>  306
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M036

<400>  306

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Thr Leu Pro Gln Met Ser Gln 
                325                 330                 335     


Phe Thr Cys Cys Glu Asp Phe Tyr Phe Pro Trp Leu Leu Cys Ile Ile 
            340                 345                 350         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        355                 360                 365             


<210>  307
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M037

<400>  307

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Thr Leu Pro Gln Met Ser Gln Phe Thr Cys Cys Glu Asp Phe Tyr 
        195                 200                 205             


Phe Pro Trp Leu Leu Cys Ile Ile Phe Gly Ile Phe Gly Leu Thr Val 
    210                 215                 220                 


Met Leu Phe Val Phe Leu Phe Ser 
225                 230         


<210>  308
<211>  360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M042

<400>  308

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly His Leu Pro Asp Asn Thr Leu 
                325                 330                 335     


Arg Trp Lys Val Leu Pro Gly Ile Leu Cys Leu Trp Gly Leu Phe Leu 
            340                 345                 350         


Leu Gly Cys Gly Leu Ser Leu Ala 
        355                 360 


<210>  309
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M043

<400>  309

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln His Leu Pro Asp Asn Thr Leu Arg Trp Lys Val Leu Pro Gly Ile 
        195                 200                 205             


Leu Cys Leu Trp Gly Leu Phe Leu Leu Gly Cys Gly Leu Ser Leu Ala 
    210                 215                 220                 


<210>  310
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M048

<400>  310

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Glu Thr Ala Thr Glu Thr Ala 
                325                 330                 335     


Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Asn Ala 
            340                 345                 350         


Val Leu Gly Leu Leu Leu Leu 
        355                 


<210>  311
<211>  223
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide M049

<400>  311

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu 
        195                 200                 205             


His Leu Val Leu Gly Leu Asn Ala Val Leu Gly Leu Leu Leu Leu 
    210                 215                 220             


<210>  312
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E006

<400>  312

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Leu Glu Arg Ile Ala Arg Leu 
                325                 330                 335     


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
            340                 345                 350         


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val 
        355                 360                 365             


<210>  313
<211>  369
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E007

<400>  313

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Leu Glu Arg Ile Ala Arg Leu 
                325                 330                 335     


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
            340                 345                 350         


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val 
        355                 360                 365             


Ala 
    


<210>  314
<211>  370
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E008

<400>  314

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Leu Glu Arg Ile Ala Arg Leu 
                325                 330                 335     


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
            340                 345                 350         


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val 
        355                 360                 365             


Ala Ala 
    370 


<210>  315
<211>  371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E009

<400>  315

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Leu Glu Arg Ile Ala Arg Leu 
                325                 330                 335     


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
            340                 345                 350         


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val 
        355                 360                 365             


Ala Ala Ala 
    370     


<210>  316
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E010

<400>  316

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Leu Glu Arg Ile Ala Arg Leu 
                325                 330                 335     


Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser 
            340                 345                 350         


Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val 
        355                 360                 365             


Ala Ala Ala Ala 
    370         


<210>  317
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E011

<400>  317

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu 
            20                  25                  30          


Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
        35                  40                  45              


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
    50                  55                  60                  


Leu Lys Gln Lys Val 
65                  


<210>  318
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E012

<400>  318

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu 
            20                  25                  30          


Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
        35                  40                  45              


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
    50                  55                  60                  


Leu Lys Gln Lys Val Ala 
65                  70  


<210>  319
<211>  71
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E013

<400>  319

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu 
            20                  25                  30          


Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
        35                  40                  45              


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
    50                  55                  60                  


Leu Lys Gln Lys Val Ala Ala 
65                  70      


<210>  320
<211>  72
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E014

<400>  320

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu 
            20                  25                  30          


Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
        35                  40                  45              


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
    50                  55                  60                  


Leu Lys Gln Lys Val Ala Ala Ala 
65                  70          


<210>  321
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide E015

<400>  321

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Glu 
            20                  25                  30          


Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
        35                  40                  45              


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
    50                  55                  60                  


Leu Lys Gln Lys Val Ala Ala Ala Ala 
65                  70              


<210>  322
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T001

<400>  322

Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
1               5                   10                  15      


Ala Leu Leu Val Phe Tyr Ile 
            20              


<210>  323
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T002

<400>  323

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  324
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T003

<400>  324

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  325
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T004

<400>  325

Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  326
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T005

<400>  326

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  327
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T006

<400>  327

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  328
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T007

<400>  328

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  329
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T008

<400>  329

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  330
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T009

<400>  330

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  331
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T010

<400>  331

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  332
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T011

<400>  332

Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu 
1               5                   10                  15      


Leu Val Leu Val Phe Ile 
            20          


<210>  333
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T012

<400>  333

Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro 
1               5                   10                  15      


Gly Thr Leu Leu Leu Phe 
            20          


<210>  334
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T013

<400>  334

Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val 
1               5                   10                  15      


Pro Ile Phe Leu Leu Leu 
            20          


<210>  335
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T014

<400>  335

Phe Ile Leu Ile Ser Ser Leu Ala Ile Leu Leu Met Val Ser Leu Leu 
1               5                   10                  15      


Leu Leu Ser Leu Trp 
            20      


<210>  336
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T015

<400>  336

Cys Ile Leu Ile Ser Ser Leu Ala Ile Leu Leu Met Val Ser Leu Leu 
1               5                   10                  15      


Leu Leu Ser Leu Trp 
            20      


<210>  337
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T016

<400>  337

Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
1               5                   10                  15      


Val Cys Gly Ile Val Leu Gly Phe Leu Phe 
            20                  25      


<210>  338
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T017

<400>  338

Met Trp Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu 
            


<210>  339
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T018

<400>  339

Met Trp Val Leu Ala Leu Ile Glu Ile Phe Leu Thr Ile Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu 
            


<210>  340
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T019

<400>  340

Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210>  341
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T020

<400>  341

Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Asn Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210>  342
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T021

<400>  342

Leu Ile Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu 
1               5                   10                  15      


Thr Val Leu Ala Leu Leu Ser 
            20              


<210>  343
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T022

<400>  343

Cys Cys Leu Thr Leu Ser Leu Ile Leu Val Val Ile Leu Val Leu Leu 
1               5                   10                  15      


Thr Val Leu Ala Leu Leu Ser 
            20              


<210>  344
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T023

<400>  344

Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu 
1               5                   10                  15      


Thr Leu Leu Tyr Cys 
            20      


<210>  345
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T024

<400>  345

Ile Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala 
1               5                   10                  15      


Ala Val Val Ala Leu Ile Tyr 
            20              


<210>  346
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T025

<400>  346

Ile Ile Val Ala Val Val Ile Ala Thr Ala Val Ala Ala Ile Val Ala 
1               5                   10                  15      


Ala Val Val Ala Leu Ile Tyr 
            20              


<210>  347
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T026

<400>  347

Phe Pro Trp Leu Leu Ile Ile Ile Phe Gly Ile Phe Gly Leu Thr Val 
1               5                   10                  15      


Met Leu Phe Val Phe Leu Phe Ser 
            20                  


<210>  348
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T027

<400>  348

Phe Pro Trp Leu Leu Cys Ile Ile Phe Gly Ile Phe Gly Leu Thr Val 
1               5                   10                  15      


Met Leu Phe Val Phe Leu Phe Ser 
            20                  


<210>  349
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T028

<400>  349

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  350
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T029

<400>  350

Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe Ala Leu Pro Phe 
1               5                   10                  15      


Val Ile Tyr Ala Ala 
            20      


<210>  351
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T030

<400>  351

Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val Leu Thr Ser 
1               5                   10                  15      


Thr Ile Val Thr Leu 
            20      


<210>  352
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T031

<400>  352

Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu 
1               5                   10                  15      


Ser Leu Val Phe Ile 
            20      


<210>  353
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T032

<400>  353

Val Ile Leu Ile Ser Val Gly Thr Phe Ser Leu Leu Ser Val Leu Ala 
1               5                   10                  15      


Gly Ala Cys Phe Phe 
            20      


<210>  354
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T033

<400>  354

Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu Val Ile Ala Ala 
1               5                   10                  15      


Gly Gly Val Ile Trp 
            20      


<210>  355
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T034

<400>  355

His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
1               5                   10                  15      


Val Phe Ile Tyr Lys Ile Phe 
            20              


<210>  356
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T035

<400>  356

Val Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu 
1               5                   10                  15      


Glu Met Val Leu Phe 
            20      


<210>  357
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T036

<400>  357

Ile Tyr Cys Ile Ile Ala Val Cys Ser Val Phe Leu Met Leu Ile Asn 
1               5                   10                  15      


Val Leu Val Ile Ile 
            20      


<210>  358
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T037

<400>  358

Ala Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser 
1               5                   10                  15      


Val Val Tyr Ile Tyr 
            20      


<210>  359
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T038

<400>  359

Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
1               5                   10                  15      


Ser Gly Leu 
            


<210>  360
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T039

<400>  360

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  361
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T040

<400>  361

Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu 
            20      


<210>  362
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T041

<400>  362

Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys Val 
1               5                   10                  15      


Phe Val Ile Cys 
            20  


<210>  363
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T042

<400>  363

Leu Leu Leu Gly Val Ser Val Ser Cys Ile Val Ile Leu Ala Val Cys 
1               5                   10                  15      


Leu Leu Cys Tyr Val Ser Ile Thr 
            20                  


<210>  364
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T043

<400>  364

Phe Val Ile Val Ile Met Ala Thr Ile Cys Phe Ile Leu Leu Ile Leu 
1               5                   10                  15      


Ser Leu Ile Cys 
            20  


<210>  365
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T044

<400>  365

Thr Phe Leu Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys 
1               5                   10                  15      


Ile Ala Ile Val Leu 
            20      


<210>  366
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T045

<400>  366

Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe 
            20          


<210>  367
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T046

<400>  367

Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Leu Ala Cys Val Leu 
            20              


<210>  368
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T047

<400>  368

Ile Leu Leu Pro Pro Cys Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser 
1               5                   10                  15      


Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu 
            20                  25          


<210>  369
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T048

<400>  369

Gly Asn Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly Pro 
1               5                   10                  15      


Thr Tyr Leu Leu Phe 
            20      


<210>  370
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T049

<400>  370

Val Ile Ile Phe Phe Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala 
1               5                   10                  15      


Tyr Cys Leu Ala Leu 
            20      


<210>  371
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T050

<400>  371

Trp Met Val Ala Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu 
1               5                   10                  15      


Ala Leu Leu Gly Cys Phe 
            20          


<210>  372
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T051

<400>  372

Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala Leu Ala 
1               5                   10                  15      


Leu Gly Leu Trp Leu 
            20      


<210>  373
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T052

<400>  373

Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu Leu 
1               5                   10                  15      


Val Gly Val Leu Gly Tyr Leu Gly Leu 
            20                  25  


<210>  374
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T053

<400>  374

Trp Met Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val 
1               5                   10                  15      


Gly Ile Phe Ser Thr 
            20      


<210>  375
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T054

<400>  375

Leu Tyr Ile Thr Met Leu Leu Ile Val Pro Val Ile Val Ala Gly Ala 
1               5                   10                  15      


Ile Ile Val Leu Leu Leu Tyr Leu 
            20                  


<210>  376
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T055

<400>  376

Phe Trp Leu Pro Phe Gly Phe Ile Leu Ile Leu Val Ile Phe Val Thr 
1               5                   10                  15      


Gly Leu Leu Leu 
            20  


<210>  377
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T056

<400>  377

Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
1               5                   10                  15      


Ser Leu Leu Ala Cys Tyr Leu 
            20              


<210>  378
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T057

<400>  378

Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
1               5                   10                  15      


Ile Leu Leu Ile Val 
            20      


<210>  379
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T058

<400>  379

Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val Leu Val Ala Gly 
1               5                   10                  15      


Ile Tyr Leu Met Trp 
            20      


<210>  380
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T059

<400>  380

Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ile Leu Leu Leu 
            20      


<210>  381
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T060

<400>  381

Ala Val Ala Ile Thr Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr 
1               5                   10                  15      


Leu Phe Thr Val Met 
            20      


<210>  382
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T061

<400>  382

Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala Leu Leu Thr Leu Leu Gly 
1               5                   10                  15      


Val Val Leu Ala Leu 
            20      


<210>  383
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T062

<400>  383

Gly Met Ile Ile Ala Val Leu Ile Leu Val Ala Val Val Cys Leu Val 
1               5                   10                  15      


Thr Val Cys Val Ile 
            20      


<210>  384
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T063

<400>  384

Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val 
1               5                   10                  15      


Ala Val Leu Ala Ala 
            20      


<210>  385
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T064

<400>  385

Ile Ile Phe Trp Tyr Val Leu Pro Ile Ser Ile Thr Val Phe Leu Phe 
1               5                   10                  15      


Ser Val Met Gly Tyr 
            20      


<210>  386
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T065

<400>  386

Val Leu Ala Leu Phe Ala Phe Val Gly Phe Met Leu Ile Leu Val Val 
1               5                   10                  15      


Val Pro Leu Phe Val 
            20      


<210>  387
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T066

<400>  387

Gly Trp Asn Pro His Leu Leu Leu Leu Leu Leu Leu Val Ile Val Phe 
1               5                   10                  15      


Ile Pro Ala Phe Trp 
            20      


<210>  388
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T067

<400>  388

Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly Phe Leu Val Ala 
1               5                   10                  15      


Val Leu Cys Tyr Leu 
            20      


<210>  389
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T068

<400>  389

Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser Ile Leu Ser 
1               5                   10                  15      


Leu Ile Gly Ile Phe 
            20      


<210>  390
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T069

<400>  390

Val Leu Pro Gly Ile Leu Phe Leu Trp Gly Leu Phe Leu Leu Gly Cys 
1               5                   10                  15      


Gly Leu Ser Leu Ala 
            20      


<210>  391
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T070

<400>  391

Val Leu Pro Gly Ile Leu Cys Leu Trp Gly Leu Phe Leu Leu Gly Cys 
1               5                   10                  15      


Gly Leu Ser Leu Ala 
            20      


<210>  392
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T071

<400>  392

Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu Leu Ile Leu Ile 
1               5                   10                  15      


Ile Leu Thr Val Ala Tyr Gly Leu 
            20                  


<210>  393
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T072

<400>  393

Ala Gly Leu Tyr Val Ile Val Pro Val Ile Ile Ser Ser Ser Ile Leu 
1               5                   10                  15      


Leu Leu Gly Thr Leu Leu Ile 
            20              


<210>  394
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T073

<400>  394

Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val Ile 
1               5                   10                  15      


Val Gly Val Val Thr Ser Ile Leu Cys 
            20                  25  


<210>  395
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T074

<400>  395

Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu 
            20          


<210>  396
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T075

<400>  396

Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Asn Ala Val 
1               5                   10                  15      


Leu Gly Leu Leu Leu Leu 
            20          


<210>  397
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T076

<400>  397

Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val Leu Leu Ile Met 
1               5                   10                  15      


Val Met Cys Tyr Leu 
            20      


<210>  398
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T077

<400>  398

Thr Thr Val Trp Ile Ser Val Ala Val Leu Ser Ala Val Ile Cys Leu 
1               5                   10                  15      


Ile Ile Val Trp Ala Val Ala Leu 
            20                  


<210>  399
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T078

<400>  399

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  400
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T079

<400>  400

Pro Val Leu Asp Ala Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu 
1               5                   10                  15      


Val Val Val Val Gly Ser Ser Ala Phe Leu Leu Cys 
            20                  25              


<210>  401
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T080

<400>  401

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  402
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T081

<400>  402

Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser Thr 
1               5                   10                  15      


Val Gly Leu Ile Ile 
            20      


<210>  403
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide T082

<400>  403

Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val Leu 
1               5                   10                  15      


Leu Leu Thr Ser Ala 
            20      


<210>  404
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S036

<400>  404

Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu 
1               5                   10                  15      


Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His 
            20                  25                  30          


Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro 
        35                  40                  45              


Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro 
    50                  55                  60                  


Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala 
65                  70                  75                  80  


Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg 
                85                  90                  95      


Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu 
            100                 105                 110         


Ser Pro Ser Ser Asn 
        115         


<210>  405
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S037

<400>  405

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  406
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S038

<400>  406

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  407
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S039

<400>  407

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  408
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S042

<400>  408

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  409
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S043

<400>  409

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  410
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S044

<400>  410

Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro Gln Gly Glu 
1               5                   10                  15      


Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly Tyr Tyr Ser 
            20                  25                  30          


Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile Leu Lys Thr 
        35                  40                  45              


<210>  411
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S045

<400>  411

Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu Arg Leu His 
1               5                   10                  15      


Pro Leu Glu Lys Cys Ser Arg Met Asp Tyr 
            20                  25      


<210>  412
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S046

<400>  412

Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
1               5                   10                  15  


<210>  413
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S047

<400>  413

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  414
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S048

<400>  414

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  415
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S049

<400>  415

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  416
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S050

<400>  416

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  417
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S051

<400>  417

Ser Glu Ser Ser Glu Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro 
1               5                   10                  15      


His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro 
            20                  25                  30          


Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln 
        35                  40                  45              


Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu 
    50                  55                  60                  


Arg Gln 
65      


<210>  418
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S052

<400>  418

Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser 
            20                  25                  30          


Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val 
        35                  40                  45              


Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
    50                  55                  60      


<210>  419
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S053

<400>  419

Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr 
1               5                   10                  15      


Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr 
            20                  25                  30          


Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln 
        35                  40                  45              


Glu 
    


<210>  420
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S054

<400>  420

Lys Leu Trp Arg Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro 
1               5                   10                  15      


Lys Ser Ile Phe Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln 
            20                  25                  30          


Glu Trp Ile Thr Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala 
        35                  40                  45              


Gly Ala Glu Gln Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu 
    50                  55                  60                  


Ala Lys Thr Glu Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu 
65                  70                  75                  80  


Glu Lys Glu Ala Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu 
                85                  90                  95      


Gln Gly Gly Asp Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn 
            100                 105                 110         


Asp Arg Ser Tyr Val Ala Leu 
        115                 


<210>  421
<211>  437
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S057

<400>  421

Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210>  422
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S058

<400>  422

Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile 
1               5                   10                  15      


Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp 
            20                  25                  30          


Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu 
        35                  40                  45              


Thr Val Lys Glu Ile Thr 
    50                  


<210>  423
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S059

<400>  423

Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile 
1               5                   10                  15      


Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu Asp Glu Met Gly Pro 
            20                  25                  30          


Gln Arg His His Arg Cys Gly Trp Asn Leu Tyr Pro Thr Pro Gly Pro 
        35                  40                  45              


Ser Pro Gly Ser Gly Ser Ser Pro Arg Leu Gly Ser Glu Ser Ser Leu 
    50                  55                  60                  


<210>  424
<211>  186
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S062

<400>  424

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr 
                85                  90                  95      


Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro 
            100                 105                 110         


Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala 
        115                 120                 125             


Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala 
    130                 135                 140                 


Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro Ser Gln Glu Asp Asp 
145                 150                 155                 160 


Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg 
                165                 170                 175     


Val His Gly Met Glu Ala Leu Gly Ser Phe 
            180                 185     


<210>  425
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S063

<400>  425

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Leu Pro 
            20                  25                  30          


Gly Pro Arg Gln Gly Gln Trp Leu Gly Gln Thr Ser Glu Met Ser Arg 
        35                  40                  45              


Ala Leu Thr Pro His Pro Cys Val Gln Asp Ala Phe Gln Leu Pro Gly 
    50                  55                  60                  


Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu 
65                  70                  75                  80  


Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly 
                85                  90                  95      


Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala 
            100                 105                 110         


Val Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu 
        115                 120                 125             


Tyr Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr 
    130                 135                 140                 


Leu Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser 
145                 150                 155                 160 


Pro Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr 
                165                 170                 175     


Leu Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro 
            180                 185                 190         


Leu Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu 
        195                 200                 205             


Ala Leu Gly Ser Phe 
    210             


<210>  426
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S064

<400>  426

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr 
                85                  90                  95      


Ser Asp Gln Ala Gly Pro Pro Arg Arg Ser Ala Tyr Phe Lys Asp Gln 
            100                 105                 110         


Ile Met Leu His Pro Ala Pro Pro Asn Gly Leu Leu Cys Leu Phe Pro 
        115                 120                 125             


Ile Thr Ser Val Leu 
    130             


<210>  427
<211>  235
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S069

<400>  427

His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
1               5                   10                  15      


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
            20                  25                  30          


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
        35                  40                  45              


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
    50                  55                  60                  


Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly 
65                  70                  75                  80  


Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu 
                85                  90                  95      


Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu 
            100                 105                 110         


Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser 
        115                 120                 125             


Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu 
    130                 135                 140                 


Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser 
145                 150                 155                 160 


Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro 
                165                 170                 175     


Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser 
            180                 185                 190         


Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser 
        195                 200                 205             


Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala 
    210                 215                 220                 


Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
225                 230                 235 


<210>  428
<211>  235
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S072

<400>  428

His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
1               5                   10                  15      


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
            20                  25                  30          


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
        35                  40                  45              


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
    50                  55                  60                  


Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly 
65                  70                  75                  80  


Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu 
                85                  90                  95      


Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu 
            100                 105                 110         


Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser 
        115                 120                 125             


Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu 
    130                 135                 140                 


Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser 
145                 150                 155                 160 


Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro 
                165                 170                 175     


Pro His Leu Lys Phe Leu Phe Leu Val Val Ser Asp Ser Gly Ile Ser 
            180                 185                 190         


Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser 
        195                 200                 205             


Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala 
    210                 215                 220                 


Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
225                 230                 235 


<210>  429
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S074

<400>  429

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  430
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S075

<400>  430

Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Pro Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210>  431
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S076

<400>  431

Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210>  432
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S077

<400>  432

Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
1               5                   10                  15      


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
            20                  25                  30          


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
        35                  40                  45              


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
    50                  55                  60                  


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
65                  70                  75                  80  


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
                85                  90                  95      


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
            100                 105                 110         


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
        115                 120                 125             


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
    130                 135                 140                 


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
145                 150                 155                 160 


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
                165                 170                 175     


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
            180                 185                 190         


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
        195                 200                 205             


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
    210                 215                 220                 


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
225                 230                 235                 240 


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
                245                 250                 255     


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
            260                 265                 270         


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
        275                 280                 285             


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
    290                 295                 300                 


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
305                 310                 315                 320 


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
                325                 330                 335     


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
            340                 345                 350 


<210>  433
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S080

<400>  433

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  434
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S081

<400>  434

Lys Val Phe Leu Arg Cys Ile Asn Tyr Val Phe Phe Pro Ser Leu Lys 
1               5                   10                  15      


Pro Ser Ser Ser Ile Asp Glu Tyr Phe Ser Glu Gln Pro Leu Lys Asn 
            20                  25                  30          


Leu Leu Leu Ser Thr Ser Glu Glu Gln Ile Glu Lys Cys Phe Ile Ile 
        35                  40                  45              


Glu Asn Ile Ser Thr Ile Ala Thr Val Glu Glu Thr Asn Gln Thr Asp 
    50                  55                  60                  


Glu Asp His Lys Lys Tyr Ser Ser Gln Thr Ser Gln Asp Ser Gly Asn 
65                  70                  75                  80  


Tyr Ser Asn Glu Asp Glu Ser Glu Ser Lys Thr Ser Glu Glu Leu Gln 
                85                  90                  95      


Gln Asp Phe Val 
            100 


<210>  435
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S082

<400>  435

Lys Trp Ile Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu 
1               5                   10                  15      


Asn Phe His Asn Phe Leu Ala Trp Pro Phe Pro Asn Leu Pro Pro Leu 
            20                  25                  30          


Glu Ala Met Asp Met Val Glu Val Ile Tyr Ile Asn Arg Lys Lys Lys 
        35                  40                  45              


Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp Thr Glu Ala 
    50                  55                  60                  


Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly Leu Thr Val 
65                  70                  75                  80  


Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr Glu Ser Gln Leu Ile 
                85                  90                  95      


Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro Glu Val Asp Val Glu 
            100                 105                 110         


Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln Leu Glu Leu Leu Ser 
        115                 120                 125             


Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln Asp Pro Phe Pro Glu 
    130                 135                 140                 


Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly Arg Ile Thr Phe Asn 
145                 150                 155                 160 


Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu Asp Asp Glu Asp Ser 
                165                 170                 175     


Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser His Leu Glu Glu Met 
            180                 185                 190         


Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser Asn His Leu Leu Ala 
        195                 200                 205             


Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser Pro Ser Ser Glu Gly 
    210                 215                 220                 


Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr Ser Glu Ser 
225                 230                 235                 240 


Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
                245                 250     


<210>  436
<211>  67
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S083

<400>  436

Lys Trp Ile Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu 
1               5                   10                  15      


Arg Gln Gly Leu Ala Lys Gly Trp Asn Ala Val Ala Ile His Arg Cys 
            20                  25                  30          


Ser His Asn Ala Leu Gln Ser Glu Thr Pro Glu Leu Lys Gln Ser Ser 
        35                  40                  45              


Cys Leu Ser Phe Pro Ser Ser Trp Asp Tyr Lys Arg Ala Ser Leu Cys 
    50                  55                  60                  


Pro Ser Asp 
65          


<210>  437
<211>  223
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S084

<400>  437

Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile 
1               5                   10                  15      


Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr 
            20                  25                  30          


Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe 
        35                  40                  45              


Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr 
    50                  55                  60                  


Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr 
65                  70                  75                  80  


Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile 
                85                  90                  95      


Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser 
            100                 105                 110         


Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu 
        115                 120                 125             


Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn 
    130                 135                 140                 


Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser 
145                 150                 155                 160 


Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly 
                165                 170                 175     


Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp 
            180                 185                 190         


Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys Glu 
        195                 200                 205             


Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser 
    210                 215                 220             


<210>  438
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S085

<400>  438

Leu Val Leu Lys Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro 
1               5                   10                  15      


Pro Ser Ile Pro Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln 
            20                  25                  30          


Pro Ile Leu Glu Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val 
        35                  40                  45              


Trp Asp Ser Val Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp 
    50                  55                  60                  


Val Leu Gln Thr Leu 
65                  


<210>  439
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S086

<400>  439

Lys Thr Leu Met Gly Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg 
1               5                   10                  15      


Ala Leu Asp Phe Ser Gly His Thr His Pro Val Ala Thr Phe Gln Pro 
            20                  25                  30          


Ser Arg Pro Glu Ser Val Asn Asp Leu Phe Leu Cys Pro Gln Lys Glu 
        35                  40                  45              


Leu Thr Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala Pro Ala Thr 
    50                  55                  60                  


Gln Gln Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Glu Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro Tyr Ile Glu 
                85                  90                  95      


Pro Pro Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly His Ser Glu 
            100                 105                 110         


Ala Gly Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu Val Pro Ser 
        115                 120                 125             


Glu Gly Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp Ala Ser Thr 
    130                 135                 140                 


Val Asp Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln Glu Ser Leu 
                165                 170                 175     


Pro Pro Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu Glu Leu Pro 
            180                 185                 190         


Glu Asp Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu Pro Pro Glu 
        195                 200                 205             


Pro Asn Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln Thr Leu Thr 
    210                 215                 220                 


Phe Cys Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala Arg Glu Ser 
225                 230                 235                 240 


Glu Ile Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu Ser Thr Gln 
                245                 250                 255     


Arg Thr Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met Ala Arg 
            260                 265                 270     


<210>  440
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S087

<400>  440

Lys Thr Leu Met Gly Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg 
1               5                   10                  15      


Ala Leu Glu Leu Thr Arg Gly Val Arg Pro Thr Pro Arg Val Arg Ala 
            20                  25                  30          


Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys Asp Leu Ala Glu Asp Glu 
        35                  40                  45              


Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp Gly Val Ser Phe Gln Pro 
    50                  55                  60                  


Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln Glu His Gln Ala Pro Gly 
65                  70                  75                  80  


His Ser Glu Ala Gly Gly Val Asp Ser Gly Arg Pro Arg Ala Pro Leu 
                85                  90                  95      


Val Pro Ser Glu Gly Ser Ser Ala Trp Asp Ser Ser Asp Arg Ser Trp 
            100                 105                 110         


Ala Ser Thr Val Asp Ser Ser Trp Asp Arg Ala Gly Ser Ser Gly Tyr 
        115                 120                 125             


Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro Gly Gly Asp Gly His Gln 
    130                 135                 140                 


Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys Asp Ser Gly Phe Leu Glu 
145                 150                 155                 160 


Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp Ala Thr Trp Gly Thr Leu 
                165                 170                 175     


Pro Pro Glu Pro Asn Leu Val Pro Gly Gly Pro Pro Val Ser Leu Gln 
            180                 185                 190         


Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro Glu Glu Glu Glu Glu Ala 
        195                 200                 205             


Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala Gly Ser Trp Gly Ala Glu 
    210                 215                 220                 


Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg Thr Leu Gly His Tyr Met 
225                 230                 235                 240 


Ala Arg 
        


<210>  441
<211>  179
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S098

<400>  441

Lys Ile Asp Ile Val Leu Trp Tyr Arg Asp Ser Cys Tyr Asp Phe Leu 
1               5                   10                  15      


Pro Ile Lys Val Leu Pro Glu Val Leu Glu Lys Gln Cys Gly Tyr Lys 
            20                  25                  30          


Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val Gly Glu Asp Ile Val Glu 
        35                  40                  45              


Val Ile Asn Glu Asn Val Lys Lys Ser Arg Arg Leu Ile Ile Ile Leu 
    50                  55                  60                  


Val Arg Glu Thr Ser Gly Phe Ser Trp Leu Gly Gly Ser Ser Glu Glu 
65                  70                  75                  80  


Gln Ile Ala Met Tyr Asn Ala Leu Val Gln Asp Gly Ile Lys Val Val 
                85                  90                  95      


Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr Glu Lys Met Pro Glu Ser 
            100                 105                 110         


Ile Lys Phe Ile Lys Gln Lys His Gly Ala Ile Arg Trp Ser Gly Asp 
        115                 120                 125             


Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr Arg Phe Trp Lys Asn Val 
    130                 135                 140                 


Arg Tyr His Met Pro Val Gln Arg Arg Ser Pro Ser Ser Lys His Gln 
145                 150                 155                 160 


Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu Gln Arg Glu Ala His Val 
                165                 170                 175     


Pro Leu Gly 
            


<210>  442
<211>  210
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S099

<400>  442

Lys Ile Asp Ile Val Leu Trp Tyr Arg Asp Ser Cys Tyr Asp Phe Leu 
1               5                   10                  15      


Pro Ile Lys Ala Ser Asp Gly Lys Thr Tyr Asp Ala Tyr Ile Leu Tyr 
            20                  25                  30          


Pro Lys Thr Val Gly Glu Gly Ser Thr Ser Asp Cys Asp Ile Phe Val 
        35                  40                  45              


Phe Lys Val Leu Pro Glu Val Leu Glu Lys Gln Cys Gly Tyr Lys Leu 
    50                  55                  60                  


Phe Ile Tyr Gly Arg Asp Asp Tyr Val Gly Glu Asp Ile Val Glu Val 
65                  70                  75                  80  


Ile Asn Glu Asn Val Lys Lys Ser Arg Arg Leu Ile Ile Ile Leu Val 
                85                  90                  95      


Arg Glu Thr Ser Gly Phe Ser Trp Leu Gly Gly Ser Ser Glu Glu Gln 
            100                 105                 110         


Ile Ala Met Tyr Asn Ala Leu Val Gln Asp Gly Ile Lys Val Val Leu 
        115                 120                 125             


Leu Glu Leu Glu Lys Ile Gln Asp Tyr Glu Lys Met Pro Glu Ser Ile 
    130                 135                 140                 


Lys Phe Ile Lys Gln Lys His Gly Ala Ile Arg Trp Ser Gly Asp Phe 
145                 150                 155                 160 


Thr Gln Gly Pro Gln Ser Ala Lys Thr Arg Phe Trp Lys Asn Val Arg 
                165                 170                 175     


Tyr His Met Pro Val Gln Arg Arg Ser Pro Ser Ser Lys His Gln Leu 
            180                 185                 190         


Leu Ser Pro Ala Thr Lys Glu Lys Leu Gln Arg Glu Ala His Val Pro 
        195                 200                 205             


Leu Gly 
    210 


<210>  443
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S100

<400>  443

Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
1               5                   10                  15      


Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu Glu Glu Glu Phe 
            20                  25                  30          


Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
        35                  40                  45              


Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
    50                  55                  60                  


Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
65                  70                  75                  80  


Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
                85                  90                  95      


Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile Asn Val Ile Leu 
            100                 105                 110         


Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys Glu Leu Lys Arg 
        115                 120                 125             


Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
    130                 135                 140                 


Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
145                 150                 155                 160 


Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln Gly Leu Ser Tyr 
                165                 170                 175     


Ser Ser Leu Lys Asn Val 
            180         


<210>  444
<211>  299
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S101

<400>  444

Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
1               5                   10                  15      


Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu Glu Glu Glu Phe 
            20                  25                  30          


Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
        35                  40                  45              


Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Asn Thr Val Glu 
    50                  55                  60                  


Ala Val Phe Asp Phe Ile Gln Arg Ser Arg Arg Met Ile Val Val Leu 
65                  70                  75                  80  


Ser Pro Asp Tyr Val Thr Glu Lys Ser Ile Ser Met Leu Glu Phe Lys 
                85                  90                  95      


Leu Gly Val Met Cys Gln Asn Ser Ile Ala Thr Lys Leu Ile Val Val 
            100                 105                 110         


Glu Tyr Arg Pro Leu Glu His Pro His Pro Gly Ile Leu Gln Leu Lys 
        115                 120                 125             


Glu Ser Val Ser Phe Val Ser Trp Lys Gly Glu Lys Ser Lys His Ser 
    130                 135                 140                 


Gly Ser Lys Phe Trp Lys Ala Leu Arg Leu Ala Leu Pro Leu Arg Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Ser Gly Trp Asn Glu Ser Cys Ser Ser Gln Ser Asp 
                165                 170                 175     


Ile Ser Leu Asp His Val Gln Arg Arg Arg Ser Arg Leu Lys Glu Pro 
            180                 185                 190         


Pro Glu Leu Gln Ser Ser Glu Arg Ala Ala Gly Ser Pro Pro Ala Pro 
        195                 200                 205             


Gly Thr Met Ser Lys His Arg Gly Lys Ser Ser Ala Thr Cys Arg Cys 
    210                 215                 220                 


Cys Val Thr Tyr Cys Glu Gly Glu Asn His Leu Arg Asn Lys Ser Arg 
225                 230                 235                 240 


Ala Glu Ile His Asn Gln Pro Gln Trp Glu Thr His Leu Cys Lys Pro 
                245                 250                 255     


Val Pro Gln Glu Ser Glu Thr Gln Trp Ile Gln Asn Gly Thr Arg Leu 
            260                 265                 270         


Glu Pro Pro Ala Pro Gln Ile Ser Ala Leu Ala Leu His His Phe Thr 
        275                 280                 285             


Asp Leu Ser Asn Asn Asn Asp Phe Tyr Ile Leu 
    290                 295                 


<210>  445
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S102

<400>  445

Leu Lys Met Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala 
1               5                   10                  15      


Lys Pro Tyr Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val 
            20                  25                  30          


Val Tyr Pro Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val 
        35                  40                  45              


Glu His Phe Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys 
    50                  55                  60                  


Gly Tyr Thr Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp 
65                  70                  75                  80  


Val Val Thr Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile 
                85                  90                  95      


Phe Ile Leu Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu 
            100                 105                 110         


Gln Glu Val Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val 
        115                 120                 125             


Ile Leu Ile Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala 
    130                 135                 140                 


Glu Ala Leu Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr 
145                 150                 155                 160 


Ile Lys Trp Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser 
                165                 170                 175     


Lys Phe Trp Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile 
            180                 185                 190         


Pro Arg Lys Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
        195                 200                 205         


<210>  446
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S103

<400>  446

Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg Ser Ala Phe His 
1               5                   10                  15      


Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp Ala Tyr Val Leu 
            20                  25                  30          


Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala Val Asp Ala Leu 
        35                  40                  45              


Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln Cys Gly Tyr Lys 
    50                  55                  60                  


Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln Ala Val Ala Asn 
65                  70                  75                  80  


Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu Ile Val Ile Val 
                85                  90                  95      


Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn Leu Ser Glu Glu 
            100                 105                 110         


Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly Met Lys Val Ile 
        115                 120                 125             


Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val Met Pro Glu Ser 
    130                 135                 140                 


Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg Trp His Gly Asp 
145                 150                 155                 160 


Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe Trp Lys Thr Val 
                165                 170                 175     


Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe Pro Pro Val Gln 
            180                 185                 190         


Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly Pro Glu Leu Gly 
        195                 200                 205             


Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
    210                 215                 


<210>  447
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S104

<400>  447

Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
1               5                   10              


<210>  448
<211>  286
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S105

<400>  448

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  449
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S106

<400>  449

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  450
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S109

<400>  450

Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro Arg Ile Pro His Met 
1               5                   10                  15      


Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp Lys Leu Val Val Trp 
            20                  25                  30          


Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu Val Thr Glu Val Gln 
        35                  40                  45              


Val Val Gln Lys Thr 
    50              


<210>  451
<211>  569
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S110

<400>  451

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  452
<211>  569
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S113

<400>  452

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Phe Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  453
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S115

<400>  453

Lys Ile Cys His Leu Trp Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro 
1               5                   10                  15      


Lys Ser Asn Ile Lys Asp Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala 
            20                  25                  30          


Gly Ser Ser Glu Thr Glu Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro 
        35                  40                  45              


Gly Val Glu Thr Leu Glu Asp Ser Val Phe 
    50                  55              


<210>  454
<211>  82
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S116

<400>  454

Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly Lys Thr 
1               5                   10                  15      


Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu Arg Pro 
            20                  25                  30          


Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val Ser Pro 
        35                  40                  45              


Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro Asp Ala 
    50                  55                  60                  


Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr Phe Phe 
65                  70                  75                  80  


Pro Arg 
        


<210>  455
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S117

<400>  455

Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    130                 135                 140                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                165                 170                 175     


Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu Arg 
            180                 185                 190         


Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu Lys 
        195                 200                 205             


Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln Met 
    210                 215                 220                 


Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala Thr 
                245                 250                 255     


Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            260                 265                 270         


Gly Tyr Met Pro Gln 
        275         


<210>  456
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S120

<400>  456

Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His 
1               5                   10                  15      


Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn 
            20                  25                  30          


Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val 
        35                  40                  45              


Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
    50                  55                  60                  


Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp 
65                  70                  75                  80  


Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu 
                85                  90                  95      


Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser 
            100                 105                 110         


Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg 
        115                 120                 125             


Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser 
    130                 135                 140                 


Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser 
145                 150                 155                 160 


Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr 
                165                 170                 175     


Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe 
            180                 185                 190         


Tyr Gln Asn Gln 
        195     


<210>  457
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S121

<400>  457

Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His 
1               5                   10                  15      


Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Val Ser Val 
            20                  25                  30          


Phe Gly Ala 
        35  


<210>  458
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S126

<400>  458

Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn Val Pro Ser 
1               5                   10                  15      


Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn Gly Asn Phe 
            20                  25                  30          


Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu Ser Gln Asp 
        35                  40                  45              


Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val Gln Glu Ala 
    50                  55                  60                  


Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys Ser Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro Gly Asn Leu 
                85                  90                  95      


Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp Arg Val Gln 
            100                 105                 110         


Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr Ser Leu Thr 
        115                 120                 125             


Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser Gly Pro Ile 
                165                 170                 175     


Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly Leu Glu Thr 
            180                 185                 190         


Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln Arg Pro Gly 
        195                 200                 205             


Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val Leu Ser Lys 
    210                 215                 220                 


Ala Arg Ser Trp Thr Phe 
225                 230 


<210>  459
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S129

<400>  459

Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
1               5                   10                  15      


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
            20                  25                  30          


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
        35                  40                  45              


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
    50                  55                  60                  


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
65                  70                  75                  80  


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
                85                  90                  95      


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
            100                 105                 110         


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
        115                 120                 125             


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
    130                 135                 140                 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
145                 150                 155                 160 


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
                165                 170                 175     


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
            180                 185                 190         


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
        195                 200                 205             


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
    210                 215                 220                 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
225                 230                 235                 240 


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
                245                 250                 255     


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
            260                 265                 270         


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
        275                 280                 285             


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
    290                 295                 300                 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
305                 310                 315                 320 


Ser Glu 
        


<210>  460
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S130

<400>  460

Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe Ser Pro 
1               5                   10                  15      


Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His Pro His 
            20                  25                  30          


His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu Asn Asp 
        35                  40                  45              


Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser Gly Lys 
    50                  55                  60                  


Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly Gln Gly 
65                  70                  75                  80  


Pro Gln Ser 
            


<210>  461
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S135

<400>  461

Arg Leu Arg Arg Gly Gly Lys Asp Gly Ser Pro Lys Pro Gly Phe Leu 
1               5                   10                  15      


Ala Ser Val Ile Pro Val Asp Arg Arg Pro Gly Ala Pro Asn Leu 
            20                  25                  30      


<210>  462
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S136

<400>  462

Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala 
1               5                   10                  15      


Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile 
            20                  25                  30          


Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val 
        35                  40                  45              


Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys 
    50                  55                  60                  


Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu 
65                  70                  75                  80  


Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
                85                  90          


<210>  463
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S137

<400>  463

Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala 
1               5                   10                  15      


Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile 
            20                  25                  30          


Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val 
        35                  40                  45              


Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys 
    50                  55                  60                  


Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu 
65                  70                  75                  80  


Ser Leu Glu Asp Gly Asp Arg Cys Asp Arg 
                85                  90  


<210>  464
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S138

<400>  464

His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro 
1               5                   10                  15      


Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala 
            20                  25                  30          


Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg 
        35                  40                  45              


Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile 
    50                  55                  60                  


Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys 
65                  70                  75                  80  


Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser 
                85                  90                  95      


Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala 
            100                 105                 110         


Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu 
        115                 120                 125             


Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
    130                 135                 140                 


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
145                 150                 155                 160 


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
                165                 170                 175     


Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser 
            180                 185                 190         


Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp 
        195                 200                 205             


Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    210                 215                 


<210>  465
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S141

<400>  465

Lys Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys 
1               5                   10                  15      


Ile Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp 
            20                  25                  30          


Lys Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser 
        35                  40                  45              


Val Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
    50                  55                  60  


<210>  466
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S142

<400>  466

Arg Lys Pro Asn Thr Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp 
1               5                   10                  15      


Thr 
    


<210>  467
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S143

<400>  467

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  468
<211>  525
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S144

<400>  468

Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser Glu Lys Tyr Ser Asp 
1               5                   10                  15      


Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala Asp Leu Ile Pro Pro 
            20                  25                  30          


Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr Ser Ala Asp His Pro 
        35                  40                  45              


Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln Phe Leu Leu Thr Ala 
    50                  55                  60                  


Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu Glu Gln Ala Ile Ser 
65                  70                  75                  80  


Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln Lys Gln Glu Met Val 
                85                  90                  95      


Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser Arg Gly Thr Arg Ala 
            100                 105                 110         


Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro Val Arg Leu Arg Cys 
        115                 120                 125             


Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr Ala Ala Met Asn Met 
    130                 135                 140                 


Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe Gly Thr Tyr Val Val 
145                 150                 155                 160 


Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp Val Pro Asp Leu Phe 
                165                 170                 175     


Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg Phe Glu Glu Val Tyr 
            180                 185                 190         


Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro Gly Arg Met His Arg 
        195                 200                 205             


Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg Ser Pro Gly Gly Arg 
    210                 215                 220                 


Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp Trp Gln Val Arg Cys 
225                 230                 235                 240 


Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser Ala Asp Asp Gln Asp 
                245                 250                 255     


Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu Pro Leu Leu Pro Pro 
            260                 265                 270         


Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val Arg Glu Pro Gly Ser 
        275                 280                 285             


Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly Glu Glu Gly Gly Ala 
    290                 295                 300                 


Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro Arg Gly Gln Pro Ala 
305                 310                 315                 320 


Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala Glu Glu Gly Ala Leu 
                325                 330                 335     


Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp Gly Ala Ala Val Arg 
            340                 345                 350         


Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro Leu Leu Gly Ser Pro 
        355                 360                 365             


Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro Val Asp Pro Glu Asp 
    370                 375                 380                 


Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser Pro Asp Leu Leu Pro 
385                 390                 395                 400 


Glu Asp Val Arg Glu His Leu Glu Gly Leu Met Leu Ser Leu Phe Glu 
                405                 410                 415     


Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys Ser Arg Pro Ala Met 
            420                 425                 430         


Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu Glu Gln Arg Gln Ser 
        435                 440                 445             


Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser Ser Pro Gln Pro Pro 
    450                 455                 460                 


Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu Glu Glu Gln Asp Pro 
465                 470                 475                 480 


Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp Leu Glu Ser Leu Arg 
                485                 490                 495     


Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu Gln Lys Asn Ser Gly 
            500                 505                 510         


Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro Ser Ala 
        515                 520                 525 


<210>  469
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S145

<400>  469

Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu 
1               5                   10                  15      


Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His 
            20                  25                  30          


His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser 
        35                  40                  45              


Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly 
    50                  55                  60                  


Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val 
65                  70                  75                  80  


Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly 
                85                  90                  95      


Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu 
            100                 105                 110         


Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His Leu His 
        115                 120                 125             


Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr 
    130                 135                 140                 


Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr 
145                 150                 155                 160 


Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser Ala Gly 
                165                 170                 175     


Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 


<210>  470
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S146

<400>  470

Lys Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val 
1               5                   10                  15      


Arg Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser 
            20                  25                  30          


Ala Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala 
        35                  40                  45              


Leu Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg 
    50                  55                  60                  


Glu Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg 
65                  70                  75                  80  


Gln Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly 
                85                  90                  95      


Ala Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro 
            100                 105                 110         


Gly Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val 
        115                 120                 125             


Leu Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala 
    130                 135                 140                 


Cys Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg 
145                 150                 155                 160 


Thr Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly 
                165                 170                 175     


Ala Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg 
            180                 185                 190         


Ala Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe 
        195                 200                 205             


His Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala 
    210                 215                 220                 


Gly Pro Gly Ala Gly Asp Gly Thr 
225                 230         


<210>  471
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S147

<400>  471

Lys Lys Asp His Ala Lys Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu 
1               5                   10                  15      


Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu 
            20                  25                  30          


Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp 
        35                  40                  45              


Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala 
    50                  55                  60                  


Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe 
65                  70                  75                  80  


Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val 
                85                  90                  95      


Ser Gly Pro Gly Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu 
            100                 105                 110         


Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr 
        115                 120                 125             


Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala 
    130                 135                 140                 


Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp 
145                 150                 155                 160 


Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu 
                165                 170                 175     


Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp 
            180                 185                 190         


Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly 
        195                 200                 205             


Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
    210                 215                 


<210>  472
<211>  419
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S148

<400>  472

Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
1               5                   10                  15      


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
            20                  25                  30          


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
        35                  40                  45              


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
    50                  55                  60                  


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
65                  70                  75                  80  


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
                85                  90                  95      


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
            100                 105                 110         


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
        115                 120                 125             


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
    130                 135                 140                 


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
145                 150                 155                 160 


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
                165                 170                 175     


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
            180                 185                 190         


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
        195                 200                 205             


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
    210                 215                 220                 


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
225                 230                 235                 240 


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
                245                 250                 255     


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
            260                 265                 270         


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
        275                 280                 285             


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
    290                 295                 300                 


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
305                 310                 315                 320 


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
                325                 330                 335     


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
            340                 345                 350         


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
        355                 360                 365             


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
    370                 375                 380                 


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
385                 390                 395                 400 


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
                405                 410                 415     


Ala Pro Leu 
            


<210>  473
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S149

<400>  473

Thr Cys Arg Arg Pro Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala 
            20                  25                  30          


Leu Ala Glu Leu Leu Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile 
        35                  40                  45              


Val Asp Leu Trp Glu Gly Arg His Val Ala Arg Val Gly Pro Leu Pro 
    50                  55                  60                  


Trp Leu Trp Ala Ala Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val 
65                  70                  75                  80  


Leu Leu Leu Trp Ser Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp 
                85                  90                  95      


Pro Arg Ala Ala Pro Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro 
            100                 105                 110         


Leu Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile 
        115                 120                 125             


Pro Pro Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu 
    130                 135                 140                 


Pro Arg Leu Leu Arg Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr 
145                 150                 155                 160 


Ser Trp Gly Arg Leu Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu 
                165                 170                 175     


Leu Cys Ser Arg Leu Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            180                 185                 190         


<210>  474
<211>  191
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S154

<400>  474

Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp 
1               5                   10                  15      


Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu 
            20                  25                  30          


Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu 
        35                  40                  45              


Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile 
    50                  55                  60                  


Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His 
65                  70                  75                  80  


Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser 
                85                  90                  95      


Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu 
            100                 105                 110         


Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro 
        115                 120                 125             


Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser 
    130                 135                 140                 


His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser 
145                 150                 155                 160 


Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys 
                165                 170                 175     


Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
            180                 185                 190     


<210>  475
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S155

<400>  475

Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg 
1               5                   10                  15      


Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp 
            20                  25                  30          


Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr 
        35                  40                  45              


Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val 
    50                  55                  60                  


Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val 
65                  70                  75                  80  


Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg 
                85                  90                  95      


Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro 
            100                 105                 110         


Ser Ile Phe Glu Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln 
        115                 120                 125             


Thr Leu Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu 
    130                 135                 140                 


Ser Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val 
145                 150                 155                 160 


Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala 
                165                 170                 175     


Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp 
            180                 185                 190         


Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser 
        195                 200                 205             


Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
    210                 215                 220         


<210>  476
<211>  282
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S156

<400>  476

Ser Ile Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn 
1               5                   10                  15      


Leu Ile Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro 
            20                  25                  30          


Ala Glu Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp 
        35                  40                  45              


Ser Lys Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp 
    50                  55                  60                  


Val Ser Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro 
65                  70                  75                  80  


Gln Glu Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met 
                85                  90                  95      


Glu Ile Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr 
            100                 105                 110         


Gln Gln Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile 
        115                 120                 125             


Glu Tyr Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu 
    130                 135                 140                 


Glu Gln Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu 
145                 150                 155                 160 


Leu Glu Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln 
                165                 170                 175     


Tyr Ser Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu 
            180                 185                 190         


His Thr Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu 
        195                 200                 205             


Val Asp Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser 
    210                 215                 220                 


Ser Phe Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly 
225                 230                 235                 240 


Leu Gly Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro 
                245                 250                 255     


Asp Arg Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu 
            260                 265                 270         


Glu Trp Gly Leu Tyr Val Gln Met Glu Asn 
        275                 280         


<210>  477
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S157

<400>  477

Trp Lys Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val 
1               5                   10                  15      


Leu Pro Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser 
            20                  25                  30          


Cys Arg Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro 
        35                  40                  45              


Glu Glu Leu Leu Arg Ala Trp Ile Ser 
    50                  55          


<210>  478
<211>  285
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S158

<400>  478

Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala 
1               5                   10                  15      


Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser 
            20                  25                  30          


Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu 
        35                  40                  45              


Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr 
    50                  55                  60                  


Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro 
                85                  90                  95      


Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu 
            100                 105                 110         


Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val 
        115                 120                 125             


Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp 
    130                 135                 140                 


Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly 
                165                 170                 175     


Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu 
            180                 185                 190         


Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly 
        195                 200                 205             


Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu 
    210                 215                 220                 


Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly 
225                 230                 235                 240 


Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser 
                245                 250                 255     


Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val 
            260                 265                 270         


Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
        275                 280                 285 


<210>  479
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S161

<400>  479

Ser Tyr Arg Tyr Val Thr Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn 
1               5                   10                  15      


Val Gln Arg Val Leu Thr Phe Gln Pro Leu Arg Phe Ile Gln Glu His 
            20                  25                  30          


Val Leu Ile Pro Val Phe Asp Leu Ser Gly Pro Ser Ser Leu Ala Gln 
        35                  40                  45              


Pro Val Gln Tyr Ser Gln Ile Arg Val Ser Gly Pro Arg Glu Pro Ala 
    50                  55                  60                  


Gly Ala Pro Gln Arg His Ser Leu Ser Glu Ile Thr Tyr Leu Gly Gln 
65                  70                  75                  80  


Pro Asp Ile Ser Ile Leu Gln Pro Ser Asn Val Pro Pro Pro Gln Ile 
                85                  90                  95      


Leu Ser Pro Leu Ser Tyr Ala Pro Asn Ala Ala Pro Glu Val Gly Pro 
            100                 105                 110         


Pro Ser Tyr Ala Pro Gln Val Thr Pro Glu Ala Gln Phe Pro Phe Tyr 
        115                 120                 125             


Ala Pro Gln Ala Ile Ser Lys Val Gln Pro Ser Ser Tyr Ala Pro Gln 
    130                 135                 140                 


Ala Thr Pro Asp Ser Trp Pro Pro Ser Tyr Gly Val Cys Met Glu Gly 
145                 150                 155                 160 


Ser Gly Lys Asp Ser Pro Thr Gly Thr Leu Ser Ser Pro Lys His Leu 
                165                 170                 175     


Arg Pro Lys Gly Gln Leu Gln Lys Glu Pro Pro Ala Gly Ser Cys Met 
            180                 185                 190         


Leu Gly Gly Leu Ser Leu Gln Glu Val Thr Ser Leu Ala Met Glu Glu 
        195                 200                 205             


Ser Gln Glu Ala Lys Ser Leu His Gln Pro Leu Gly Ile Cys Thr Asp 
    210                 215                 220                 


Arg Thr Ser Asp Pro Asn Val Leu His Ser Gly Glu Glu Gly Thr Pro 
225                 230                 235                 240 


Gln Tyr Leu Lys Gly Gln Leu Pro Leu Leu Ser Ser Val Gln Ile Glu 
                245                 250                 255     


Gly His Pro Met Ser Leu Pro Leu Gln Pro Pro Ser Arg Pro Cys Ser 
            260                 265                 270         


Pro Ser Asp Gln Gly Pro Ser Pro Trp Gly Leu Leu Glu Ser Leu Val 
        275                 280                 285             


Cys Pro Lys Asp Glu Ala Lys Ser Pro Ala Pro Glu Thr Ser Asp Leu 
    290                 295                 300                 


Glu Gln Pro Thr Glu Leu Asp Ser Leu Phe Arg Gly Leu Ala Leu Thr 
305                 310                 315                 320 


Val Gln Trp Glu Ser 
                325 


<210>  480
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S165

<400>  480

Asn Arg Ser Phe Arg Thr Gly Ile Lys Arg Arg Ile Leu Leu Leu Ile 
1               5                   10                  15      


Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn Met Lys Asn Ser Asn Val 
            20                  25                  30          


Val Lys Met Leu Gln Glu Asn Ser Glu Leu Met Asn Asn Asn Ser Ser 
        35                  40                  45              


Glu Gln Val Leu Tyr Val Asp Pro Met Ile Thr Glu Ile Lys Glu Ile 
    50                  55                  60                  


Phe Ile Pro Glu His Lys Pro Thr Asp Tyr Lys Lys Glu Asn Thr Gly 
65                  70                  75                  80  


Pro Leu Glu Thr Arg Asp Tyr Pro Gln Asn Ser Leu Phe Asp Asn Thr 
                85                  90                  95      


Thr Val Val Tyr Ile Pro Asp Leu Asn Thr Gly Tyr Lys Pro Gln Ile 
            100                 105                 110         


Ser Asn Phe Leu Pro Glu Gly Ser His Leu Ser Asn Asn Asn Glu Ile 
        115                 120                 125             


Thr Ser Leu Thr Leu Lys Pro Pro Val Asp Ser Leu Asp Ser Gly Asn 
    130                 135                 140                 


Asn Pro Arg Leu Gln Lys His Pro Asn Phe Ala Phe Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Ser Leu Ser Asn Thr Ile Phe Leu Gly Glu Leu Ser Leu Ile 
                165                 170                 175     


Leu Asn Gln Gly Glu Cys Ser Ser Pro Asp Ile Gln Asn Ser Val Glu 
            180                 185                 190         


Glu Glu Thr Thr Met Leu Leu Glu Asn Asp Ser Pro Ser Glu Thr Ile 
        195                 200                 205             


Pro Glu Gln Thr Leu Leu Pro Asp Glu Phe Val Ser Cys Leu Gly Ile 
    210                 215                 220                 


Val Asn Glu Glu Leu Pro Ser Ile Asn Thr Tyr Phe Pro Gln Asn Ile 
225                 230                 235                 240 


Leu Glu Ser His Phe Asn Arg Ile Ser Leu Leu Glu Lys 
                245                 250             


<210>  481
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S168

<400>  481

Thr Ser Gly Arg Cys Tyr His Leu Arg His Lys Val Leu Pro Arg Trp 
1               5                   10                  15      


Val Trp Glu Lys Val Pro Asp Pro Ala Asn Ser Ser Ser Gly Gln Pro 
            20                  25                  30          


His Met Glu Gln Val Pro Glu Ala Gln Pro Leu Gly Asp Leu Pro Ile 
        35                  40                  45              


Leu Glu Val Glu Glu Met Glu Pro Pro Pro Val Met Glu Ser Ser Gln 
    50                  55                  60                  


Pro Ala Gln Ala Thr Ala Pro Leu Asp Ser Gly Tyr Glu Lys His Phe 
65                  70                  75                  80  


Leu Pro Thr Pro Glu Glu Leu Gly Leu Leu Gly Pro Pro Arg Pro Gln 
                85                  90                  95      


Val Leu Ala 
            


<210>  482
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S169

<400>  482

Thr Ser Trp Val Trp Glu Lys Val Pro Asp Pro Ala Asn Ser Ser Ser 
1               5                   10                  15      


Gly Gln Pro His Met Glu Gln Val Pro Glu Ala Gln Pro Leu Gly Asp 
            20                  25                  30          


Leu Pro Ile Leu Glu Val Glu Glu Met Glu Pro Pro Pro Val Met Glu 
        35                  40                  45              


Ser Ser Gln Pro Ala Gln Ala Thr Ala Pro Leu Asp Ser Gly Tyr Glu 
    50                  55                  60                  


Lys His Phe Leu Pro Thr Pro Glu Glu Leu Gly Leu Leu Gly Pro Pro 
65                  70                  75                  80  


Arg Pro Gln Val Leu Ala 
                85      


<210>  483
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S170

<400>  483

Lys Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn 
1               5                   10                  15      


Pro Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp 
            20                  25                  30          


Lys Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg 
        35                  40                  45              


Ile Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys 
    50                  55                  60                  


Leu Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu 
65                  70                  75                  80  


Ala Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr 
                85                  90                  95      


Val Thr Cys Pro Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu 
            100                 105                 110         


Glu Leu Pro Val Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu 
        115                 120                 125             


Arg Ser Arg Met Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu 
    130                 135                 140                 


Leu Phe Ser Gly Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly 
145                 150                 155                 160 


Ala Pro Asn Pro Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu 
                165                 170                 175     


Val Ser Glu Lys Leu Pro Glu His Thr Lys Gly Glu Val 
            180                 185                 


<210>  484
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S171

<400>  484

Lys Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn 
1               5                   10                  15      


Pro Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp 
            20                  25                  30          


Lys Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg 
        35                  40                  45              


Ile Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys 
    50                  55                  60                  


Leu Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu 
65                  70                  75                  80  


Ala Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Thr 
                85                  90                  95      


Arg Ile Leu Ser Ser Cys Pro Thr Ser Ile 
            100                 105     


<210>  485
<211>  303
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S174

<400>  485

Ser His Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro 
1               5                   10                  15      


Lys Asn Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr 
            20                  25                  30          


Phe Glu His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro 
        35                  40                  45              


Leu Leu Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr 
    50                  55                  60                  


Ser Trp Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu 
65                  70                  75                  80  


Leu Ser Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln 
                85                  90                  95      


Phe Asn Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr 
            100                 105                 110         


Glu Asp Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile 
        115                 120                 125             


Ser Asn Ser Lys Pro Ser Glu Thr Gly Glu Glu Gln Gly Leu Ile Asn 
    130                 135                 140                 


Ser Ser Val Thr Lys Cys Phe Ser Ser Lys Asn Ser Pro Leu Lys Asp 
145                 150                 155                 160 


Ser Phe Ser Asn Ser Ser Trp Glu Ile Glu Ala Gln Ala Phe Phe Ile 
                165                 170                 175     


Leu Ser Asp Gln His Pro Asn Ile Ile Ser Pro His Leu Thr Phe Ser 
            180                 185                 190         


Glu Gly Leu Asp Glu Leu Leu Lys Leu Glu Gly Asn Phe Pro Glu Glu 
        195                 200                 205             


Asn Asn Asp Lys Lys Ser Ile Tyr Tyr Leu Gly Val Thr Ser Ile Lys 
    210                 215                 220                 


Lys Arg Glu Ser Gly Val Leu Leu Thr Asp Lys Ser Arg Val Ser Cys 
225                 230                 235                 240 


Pro Phe Pro Ala Pro Cys Leu Phe Thr Asp Ile Arg Val Leu Gln Asp 
                245                 250                 255     


Ser Cys Ser His Phe Val Glu Asn Asn Ile Asn Leu Gly Thr Ser Ser 
            260                 265                 270         


Lys Lys Thr Phe Ala Ser Tyr Met Pro Gln Phe Gln Thr Cys Ser Thr 
        275                 280                 285             


Gln Thr His Lys Ile Met Glu Asn Lys Met Cys Asp Leu Thr Val 
    290                 295                 300             


<210>  486
<211>  96
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S175

<400>  486

Ser His Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro 
1               5                   10                  15      


Lys Asn Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Met Leu Glu 
            20                  25                  30          


Gly Ser Met Phe Val Lys Ser His His His Ser Leu Ile Ser Ser Thr 
        35                  40                  45              


Gln Gly His Lys His Cys Gly Arg Pro Gln Gly Pro Leu His Arg Lys 
    50                  55                  60                  


Thr Arg Asp Leu Cys Ser Leu Val Tyr Leu Leu Thr Leu Pro Pro Leu 
65                  70                  75                  80  


Leu Ser Tyr Asp Pro Ala Lys Ser Pro Ser Val Arg Asn Thr Gln Glu 
                85                  90                  95      


<210>  487
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S176

<400>  487

Ser His Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro 
1               5                   10                  15      


Lys Asn Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp 
            20                  25                  30          


Ile Leu 
        


<210>  488
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S177

<400>  488

Ser His Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro 
1               5                   10                  15      


Lys Asn Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Lys Met Pro 
            20                  25                  30          


Gly Thr Lys Glu Leu Leu Gly Gly Gly Trp Leu Thr 
        35                  40                  


<210>  489
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S180

<400>  489

Tyr Arg Lys Arg Glu Trp Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro 
1               5                   10                  15      


Asn Pro Glu Asn Cys Lys Ala Leu Gln Phe Gln Lys Ser Val Cys Glu 
            20                  25                  30          


Gly Ser Ser Ala Leu Lys Thr Leu Glu Met Asn Pro Cys Thr Pro Asn 
        35                  40                  45              


Asn Val Glu Val Leu Glu Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp 
    50                  55                  60                  


Thr Glu Ile Ile Ser Pro Val Ala Glu Arg Pro Glu Asp Arg Ser Asp 
65                  70                  75                  80  


Ala Glu Pro Glu Asn His Val Val Val Ser Tyr Cys Pro Pro Ile Ile 
                85                  90                  95      


Glu Glu Glu Ile Pro Asn Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala 
            100                 105                 110         


Gln Val Ile Tyr Ile Asp Val Gln Ser Met Tyr Gln Pro Gln Ala Lys 
        115                 120                 125             


Pro Glu Glu Glu Gln Glu Asn Asp Pro Val Gly Gly Ala Gly Tyr Lys 
    130                 135                 140                 


Pro Gln Met His Leu Pro Ile Asn Ser Thr Val Glu Asp Ile Ala Ala 
145                 150                 155                 160 


Glu Glu Asp Leu Asp Lys Thr Ala Gly Tyr Arg Pro Gln Ala Asn Val 
                165                 170                 175     


Asn Thr Trp Asn Leu Val Ser Pro Asp Ser Pro Arg Ser Ile Asp Ser 
            180                 185                 190         


Asn Ser Glu Ile Val Ser Phe Gly Ser Pro Cys Ser Ile Asn Ser Arg 
        195                 200                 205             


Gln Phe Leu Ile Pro Pro Lys Asp Glu Asp Ser Pro Lys Ser Asn Gly 
    210                 215                 220                 


Gly Gly Trp Ser Phe Thr Asn Phe Phe Gln Asn Lys Pro Asn Asp 
225                 230                 235                 


<210>  490
<211>  202
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S183

<400>  490

Tyr Tyr His Gly Gln Arg His Ser Asp Glu His His His Asp Asp Ser 
1               5                   10                  15      


Leu Pro His Pro Gln Gln Ala Thr Asp Asp Ser Gly His Glu Ser Asp 
            20                  25                  30          


Ser Asn Ser Asn Glu Gly Arg His His Leu Leu Val Ser Gly Ala Gly 
        35                  40                  45              


Asp Gly Pro Pro Leu Cys Ser Gln Asn Leu Gly Ala Pro Gly Gly Gly 
    50                  55                  60                  


Pro Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro 
65                  70                  75                  80  


Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp Pro Leu Pro 
                85                  90                  95      


Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn 
            100                 105                 110         


Thr Asp Asp Asn Gly Pro His Asp Pro Leu Pro His Ser Pro Ser Asp 
        115                 120                 125             


Ser Ala Gly Asn Asp Gly Gly Pro Pro Gln Leu Thr Glu Glu Val Glu 
    130                 135                 140                 


Asn Lys Gly Gly Asp Gln Gly Pro Pro Leu Met Thr Asp Gly Gly Gly 
145                 150                 155                 160 


Gly His Ser His Asp Ser Gly His Gly Gly Gly Asp Pro His Leu Pro 
                165                 170                 175     


Thr Leu Leu Leu Gly Ser Ser Gly Ser Gly Gly Asp Asp Asp Asp Pro 
            180                 185                 190         


His Gly Pro Val Gln Leu Ser Tyr Tyr Asp 
        195                 200         


<210>  491
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S186

<400>  491

Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu Trp 
1               5                   10                  15      


Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg Asp 
            20                  25                  30          


Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys Glu 
        35                  40                  45              


Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg 
    50                  55                  60                  


Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg Arg 
65                  70                  75                  80  


Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro Pro 
                85                  90                  95      


Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His Ser 
            100                 105                 110         


Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
        115                 120         


<210>  492
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S189

<400>  492

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Leu Ala Arg Arg Pro Arg Gly Gly Cys 
    210                 215                 220                 


Arg Arg Met Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu 
225                 230                 235                 240 


Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His 
                245                 250                 255     


Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe 
            260                 265                 270         


Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys 
        275                 280                 285             


Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295                 300                 


<210>  493
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S190

<400>  493

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  494
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S191

<400>  494

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met 
            100                 105                 110         


Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln 
        115                 120                 125             


Phe Val Gln Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu 
    130                 135                 140                 


Lys Leu Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp 
145                 150                 155                 160 


Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val 
                165                 170                 175     


Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr 
            180                 185                 190         


Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile 
        195                 200                 205             


Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg 
    210                 215                 220                 


Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe 
225                 230                 235                 240 


Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
                245                 250     


<210>  495
<211>  191
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S192

<400>  495

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly Ala Ala Gly Trp Trp 
145                 150                 155                 160 


Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val Thr Ser Arg 
                165                 170                 175     


Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg Ser Asp 
            180                 185                 190     


<210>  496
<211>  146
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S193

<400>  496

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly Ala Ala 
            100                 105                 110         


Gly Trp Trp Trp Leu Ser Leu Met Ile Thr Cys Arg Ala Arg Asn Val 
        115                 120                 125             


Thr Ser Arg Pro Asn Leu His Ser Ala Ser Leu Gln Val Pro Ile Arg 
    130                 135                 140                 


Ser Asp 
145     


<210>  497
<211>  172
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S194

<400>  497

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile 
                165                 170         


<210>  498
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S195

<400>  498

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met 
            100                 105                 110         


Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile 
        115                 120                 125         


<210>  499
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S196

<400>  499

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Leu Ala Arg Arg Pro Arg Gly Gly Cys 
    210                 215                 220                 


Arg Arg Met Val Val Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu 
225                 230                 235                 240 


Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His 
                245                 250                 255     


Gln Lys Arg Pro Ile Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe 
            260                 265                 270         


Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys 
        275                 280                 285             


Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295                 300                 


<210>  500
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S197

<400>  500

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Pro Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  501
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S198

<400>  501

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Gly His Met 
            100                 105                 110         


Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln 
        115                 120                 125             


Phe Val Gln Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu 
    130                 135                 140                 


Lys Leu Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp 
145                 150                 155                 160 


Ser Ile Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val 
                165                 170                 175     


Val Val Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr 
            180                 185                 190         


Lys Phe Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Pro Ile 
        195                 200                 205             


Pro Ile Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg 
    210                 215                 220                 


Phe Ile Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe 
225                 230                 235                 240 


Trp Thr Arg Leu Ala Lys Ala Leu Ser Leu Pro 
                245                 250     


<210>  502
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S199

<400>  502

Lys Ser Gln Trp Ile Lys Glu Thr Cys Tyr Pro Asp Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Lys Ser Ser Ile Leu Ser Leu Ile Lys Phe Lys Glu Asn Pro His 
            20                  25                  30          


Leu Ile Ile Met Asn Val Ser Asp Cys Ile Pro Asp Ala Ile Glu Val 
        35                  40                  45              


Val Ser Lys Pro Glu Gly Thr Lys Ile Gln Phe Leu Gly Thr Arg Lys 
    50                  55                  60                  


Ser Leu Thr Glu Thr Glu Leu Thr Lys Pro Asn Tyr Leu Tyr Leu Leu 
65                  70                  75                  80  


Pro Thr Glu Lys Asn His Ser Gly Pro Gly Pro Cys Ile Cys Phe Glu 
                85                  90                  95      


Asn Leu Thr Tyr Asn Gln Ala Ala Ser Asp Ser Gly Ser Cys Gly His 
            100                 105                 110         


Val Pro Val Ser Pro Lys Ala Pro Ser Met Leu Gly Leu Met Thr Ser 
        115                 120                 125             


Pro Glu Asn Val Leu Lys Ala Leu Glu Lys Asn Tyr Met Asn Ser Leu 
    130                 135                 140                 


Gly Glu Ile Pro Ala Gly Glu Thr Ser Leu Asn Tyr Val Ser Gln Leu 
145                 150                 155                 160 


Ala Ser Pro Met Phe Gly Asp Lys Asp Ser Leu Pro Thr Asn Pro Val 
                165                 170                 175     


Glu Ala Pro His Cys Ser Glu Tyr Lys Met Gln Met Ala Val Ser Leu 
            180                 185                 190         


Arg Leu Ala Leu Pro Pro Pro Thr Glu Asn Ser Ser Leu Ser Ser Ile 
        195                 200                 205             


Thr Leu Leu Asp Pro Gly Glu His Tyr Cys 
    210                 215             


<210>  503
<211>  364
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S202

<400>  503

Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro Gly Pro 
1               5                   10                  15      


Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys Ser Glu 
            20                  25                  30          


Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr Ser Asp 
        35                  40                  45              


Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser Glu Asp 
    50                  55                  60                  


Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln Gly Met 
65                  70                  75                  80  


Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly Ser Cys 
                85                  90                  95      


Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln Ala Asn 
            100                 105                 110         


Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu Asn Pro 
        115                 120                 125             


Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu Gly Lys 
    130                 135                 140                 


Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp Pro Leu 
145                 150                 155                 160 


Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn Ile Thr 
                165                 170                 175     


Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala Thr Leu 
            180                 185                 190         


Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr Ile Lys 
        195                 200                 205             


Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu Ser Phe 
    210                 215                 220                 


His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln Glu Lys 
225                 230                 235                 240 


Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile His Lys 
                245                 250                 255     


Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg Glu Asn 
            260                 265                 270         


Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys Glu Tyr 
        275                 280                 285             


Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu Val Pro 
    290                 295                 300                 


Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala Lys Glu 
305                 310                 315                 320 


Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu Ala Asn 
                325                 330                 335     


Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly Leu Asp 
            340                 345                 350         


Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
        355                 360                 


<210>  504
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S211

<400>  504

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  505
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S212

<400>  505

His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
1               5                   10                  15      


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
            20                  25                  30          


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
        35                  40                  45              


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
    50                  55                  60                  


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
65                  70                  75                  80  


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
                85                  90                  95      


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
            100                 105                 110         


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
        115                 120                 125             


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
    130                 135                 140                 


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
                165                 170                 175     


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185             


<210>  506
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S213

<400>  506

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  507
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S214

<400>  507

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  508
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S215

<400>  508

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  509
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide S216

<400>  509

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Lys Thr Gln Leu Leu Leu 
1               5                   10                  15      


Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu 
            20                  25                  30          


Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp 
        35                  40                  45              


Leu Trp Val 
    50      


<210>  510
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide X001

<400>  510

Gly Ser Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Ala Ala Thr 
1               5                   10                  15      


Ala Gly Ser Gly Ser Gly Ser 
            20              


<210>  511
<211>  152
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide IL7

<400>  511

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  512
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide Flexible linker

<400>  512

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  513
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide IL7RA ECD and TM

<400>  513

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr 
    210                 215                 220                 


Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala 
225                 230                 235                 240 


Cys Val Leu Trp 
                


<210>  514
<211>  286
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide IL2RB ICD

<400>  514

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  515
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide Kozak-type sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = T or U

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = G may or may not be present

<400>  515
ccaccangn                                                                9


<210>  516
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide Kozak-type sequence 2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = T or U

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = G may or may not be present

<400>  516
ccgccangn                                                                9


<210>  517
<211>  13
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide Kozak-type sequence 3


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = T or U

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n = G may or may not be present

<400>  517
gccgccgcca ngn                                                          13


<210>  518
<211>  12
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide Kozak-type sequence 4


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = T or U

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n = G may or may not be present

<400>  518
gccgccacca nn                                                           12


<210>  519
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide Kozak sequence

<400>  519
gccgccacc                                                                9


<210>  520
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide triple stop sequence

<400>  520
taatagtga                                                                9


<210>  521
<211>  191
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic nucleotide WPRE

<400>  521
gtcctttcca tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg       60

ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct      120

gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc      180

ctccccgcct g                                                           191


