                               SEQUENCE LISTING

<110> OBSIDIAN THERAPEUTICS, INC.
 
<120> IL15 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY

<130> 2095.1205PCT

<140> PCT/US2018/XXXXXX
<141> 2018-03-02

<150> 62/555,316
<151> 2017-09-07

<150> 62/484,062
<151> 2017-04-11

<150> 62/466,601
<151> 2017-03-03

<160> 536   

<170> PatentIn version 3.5

<210> 1
<211> 159
<212> PRT
<213> Escherichia coli

<400> 1
Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Arg Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155                 


<210> 2
<211> 187
<212> PRT
<213> Homo sapiens

<400> 2
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 3
<211> 107
<212> PRT
<213> Homo sapiens

<400> 3
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210> 4
<211> 327
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro 
1               5                   10                  15      


Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu 
            20                  25                  30          


Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp 
        35                  40                  45              


Leu Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys Arg 
    50                  55                  60                  


Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His 
65                  70                  75                  80  


Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu 
                85                  90                  95      


Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala 
            100                 105                 110         


Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn 
        115                 120                 125             


Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys 
    130                 135                 140                 


His Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu 
145                 150                 155                 160 


Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr 
                165                 170                 175     


Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu 
            180                 185                 190         


Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys 
        195                 200                 205             


Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala 
    210                 215                 220                 


Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro 
225                 230                 235                 240 


Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln 
                245                 250                 255     


Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met 
            260                 265                 270         


Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile 
        275                 280                 285             


Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu 
    290                 295                 300                 


Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp 
305                 310                 315                 320 


Gln Ala Leu Ala Glu Gln Gln 
                325         


<210> 5
<211> 189
<212> PRT
<213> Homo sapiens

<400> 5
Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
1               5                   10                  15      


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
            20                  25                  30          


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
        35                  40                  45              


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
    50                  55                  60                  


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
65                  70                  75                  80  


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
                85                  90                  95      


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
            100                 105                 110         


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
        115                 120                 125             


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
    130                 135                 140                 


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
145                 150                 155                 160 


His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser 
                165                 170                 175     


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            180                 185                 


<210> 6
<211> 260
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210> 7
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln Gly Lys Leu Ala Leu 
    130                 135                 140                 


Leu Ser Val Thr Thr Gly Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly 
145                 150                 155                 160 


Val Asn Gly Asp Ser Arg Tyr Phe Leu Trp Pro Leu Gln His Gly Thr 
                165                 170                 175     


Leu His Phe Cys Gly Phe Lys Val Leu Ala Pro Gln Ile Ser Phe Ala 
            180                 185                 190         


Pro Glu Ile Ala Ser Glu Glu Glu Arg Lys Gly Met Val Ala Ala Trp 
        195                 200                 205             


Ser Gln Arg Leu Gln Thr Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr 
    210                 215                 220                 


Ala His Trp His Phe Gly Gln 
225                 230     


<210> 8
<211> 159
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 8
Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155                 


<210> 9
<211> 158
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 9
Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
1               5                   10                  15      


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
            20                  25                  30          


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
        35                  40                  45              


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
    50                  55                  60                  


Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
                85                  90                  95      


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
            100                 105                 110         


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
        115                 120                 125             


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
    130                 135                 140                 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155             


<210> 10
<211> 158
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 10
Ile Ser Leu Ile Ala Ala Leu Ala Val Asp His Val Ile Gly Met Glu 
1               5                   10                  15      


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
            20                  25                  30          


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
        35                  40                  45              


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
    50                  55                  60                  


Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
                85                  90                  95      


Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
            100                 105                 110         


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Lys 
        115                 120                 125             


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
    130                 135                 140                 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155             


<210> 11
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 11
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Pro Glu 
            100                 105         


<210> 12
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 12
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
            100                 105         


<210> 13
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 13
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Val Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 14
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 14
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Ser Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 15
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 15
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asp Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 16
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 16
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Arg Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 17
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 17
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Val Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 18
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 18
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 19
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 19
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 20
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 20
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Ile Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 21
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 21
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Glu Asn Asp 
            180                 185         


<210> 22
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 22
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asp Asp 
            180                 185         


<210> 23
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 23
Met Val Gly Ser Leu Asn Arg Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Cys Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 24
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 24
Met Val Gly Ser Leu Asn Cys Ile Val Val Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala Tyr Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 25
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 25
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Lys Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 26
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 26
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Thr Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Ile Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 27
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 27
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Ala Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ala Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 28
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 28
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Gly Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 29
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 29
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Thr Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 30
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 30
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Asn Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 31
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 31
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Phe Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 32
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 32
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Ala Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Ala Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 33
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 33
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Ala Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 34
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 34
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 35
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 35
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 36
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 36
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Arg Arg Ile Met Gln Asp Leu Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 37
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 37
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys His Lys Phe Gly Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 38
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 38
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val His Glu Glu Asn Asp 
            180                 185         


<210> 39
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 39
Met Val Gly Ser Leu Asn Cys Ile Ala Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Arg Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Leu Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 40
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 40
Met Val Gly Ser Leu Asn Cys Val Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Glu Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Cys Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 41
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 41
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Ser Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Ala Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Cys Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 42
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 42
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Glu Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Leu Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Gly Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 43
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 43
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Phe Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 44
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 44
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Arg Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Val Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Cys Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 45
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 45
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Ala Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Met Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Arg Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 46
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 46
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 47
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 47
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asp Leu Val Ile Met Gly Lys Lys Thr Trp Ser Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Gly Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 48
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 48
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Glu Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Val Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Thr 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 49
<211> 603
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      promoter

<400> 49
aagcttggga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgactctact      600

aga                                                                    603


<210> 50
<211> 1339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      promoter

<400> 50
cgatagtaat tcatacaaaa ggactcgccc ctgccttggg gaatcccagg gaccgtcgtt       60

aaactcccac taacgtagaa cccagagatc gctgcgttcc cgccccctca cccgcccgct      120

ctcgtcatca ctgaggtgga gaagagcatg cgtgaggctc cggtgcccgt cagtgggcag      180

agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg      240

cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt      300

ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc      360

gcaacgggtt tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc      420

tctttacggg ttatggccct tgcgtgcctt gaattacttc cacgcccctg gctgcagtac      480

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct      540

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ttgggcgctg gggccgccgc      600

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt      660

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg      720

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt      780

gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga      840

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc      900

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg      960

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     1020

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     1080

gactccacgg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     1140

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     1200

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     1260

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     1320

ccatttcagg tgtcgtgag                                                  1339


<210> 51
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      promoter

<400> 51
ccggtaggcg ccaaccggct ccgttctttg gtggcccctt cgcgccacct tctactcctc       60

ccctagtcag gaagttcccc cccgccccgc agctcgcgtc gtgcaggacg tgacaaatgg      120

aagtagcacg tctcactagt ctcgtgcaga tggacagcac cgctgagcaa tggaagcggg      180

taggcctttg gggcagcggc caatagcagc tttgctcctt cgctttctgg gctcagaggc      240

tgggaagggg tgggtccggg ggcgggctca ggggcgggct caggggcggg gcgggcgccc      300

gaaggtcctc cggaggcccg gcattctgca cgcttcaaaa gcgcacgtct gccgcgctgt      360

tctcctcttc ctcatctccg ggcctttcga cctgcagcc                             399


<210> 52
<211> 20
<212> PRT
<213> Homo sapiens

<400> 52
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 53
Glu Phe Ser Thr Glu Phe 
1               5       


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 54
Gly Gly Ser Gly Gly 
1               5   


<210> 55
<211> 114
<212> PRT
<213> Homo sapiens

<400> 55
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 56
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser 
    130                 


<210> 57
<211> 303
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Phe Ser Thr Glu Phe Ile Ser Leu Ile Ala Ala 
            20                  25                  30          


Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn 
        35                  40                  45              


Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro 
    50                  55                  60                  


Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro 
65                  70                  75                  80  


Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr Asp Asp Arg 
                85                  90                  95      


Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp 
            100                 105                 110         


Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe 
        115                 120                 125             


Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val 
    130                 135                 140                 


Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser 
145                 150                 155                 160 


Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr 
                165                 170                 175     


Cys Phe Glu Ile Leu Glu Arg Arg Gly Gly Ser Gly Gly Asn Trp Val 
            180                 185                 190         


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
        195                 200                 205             


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
    210                 215                 220                 


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
225                 230                 235                 240 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
                245                 250                 255     


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
            260                 265                 270         


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
        275                 280                 285             


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    290                 295                 300             


<210> 58
<211> 60
<212> DNA
<213> Homo sapiens

<400> 58
atgtaccgaa tgcaactgct gagctgcatc gccctgagcc tggcactcgt gaccaacagc       60


<210> 59
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 59
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210> 60
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 60
atgtacagga tgcagctgct gagctgcatc gccctgagcc tggccctggt gaccaacagc       60


<210> 61
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 61
atgtacagaa tgcagctgct gagctgcatc gccctgtccc tcgccctggt gaccaactcc       60


<210> 62
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 62
gagttcagca ccgagttt                                                     18


<210> 63
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 63
gagttctcca ccgagttc                                                     18


<210> 64
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 64
ggaggcagcg gagga                                                        15


<210> 65
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 65
ggaggctctg gagga                                                        15


<210> 66
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 66
ggaggctccg gcgga                                                        15


<210> 67
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 67
ggaggatccg gaggc                                                        15


<210> 68
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 68
ggaggatctg gagga                                                        15


<210> 69
<211> 345
<212> DNA
<213> Homo sapiens

<400> 69
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat       60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg      120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat      180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta      240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg      300

cagagttttg tacatattgt ccaaatgttc atcaacactt cttga                      345


<210> 70
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 70
aactgggtga acgtgatctc cgacctgaag aagatcgagg acctgatcca gtccatgcac       60

atcgacgcca ccctgtacac cgagagcgac gtgcacccta gctgcaaggt gaccgccatg      120

aagtgcttcc tgctggagct gcaggtgatc agcctggaga gcggcgatgc cagcatccac      180

gacacagtgg agaacctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      240

accgagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttcctg      300

cagtccttcg tgcacatcgt gcagatgttc atcaacacca gctaa                      345


<210> 71
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 71
aactgggtca acgtgatcag cgacctgaag aagatcgagg acctcatcca gtccatgcac       60

attgacgcca ccctgtacac cgagtccgat gtgcacccta gctgcaaggt gaccgccatg      120

aaatgcttcc tgctggagct gcaggtcatc tccttagaaa gcggcgatgc ctccatccac      180

gacaccgtgg agaacctgat catcctggcc aataactccc tgagcagcaa cggcaacgtg      240

accgagagcg gctgcaaaga gtgtgaagag ctggaggaga agaacattaa ggagttcctg      300

cagagcttcg tgcacatcgt gcaaatgttc atcaacacca gctaa                      345


<210> 72
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 72
aactgggtga acgtgatctc cgacctgaaa aagatcgagg atttgatcca gagcatgcac       60

attgacgcca ccctgtatac cgagtccgac gtgcacccga gttgcaaggt gactgccatg      120

aagtgcttcc tgctggagct gcaagtgatc agcctggaga gcggcgacgc cagcatccac      180

gacaccgtgg aaaaccttat cattctggcc aacaatagcc tgagcagcaa cggcaacgtg      240

accgaaagcg gatgtaagga atgcgaggaa ctggaagaga agaatatcaa agaattcctg      300

caaagcttcg tgcacatcgt gcagatgttc atcaacactt ct                         342


<210> 73
<211> 474
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 73
atctccctga tcgccgccct ggccgtggat tatgtgatcg gcatggagaa cgccatgccc       60

tggaatctgc ccgccgacct ggcctggttc aagaggaata ccctgaacaa gcccgtcatc      120

atgggcaggc acacctggga aagcatcggc agacccctgc ccggcaggaa gaacatcatc      180

ctgtccagcc agcccggcac cgacgacaga gtgacctggg tgaagagcgt ggacgaagct      240

atcgccgctt gcggcgacgt gcccgagatc atggtgatcg gcggcggcag ggtgatcgaa      300

cagttcctgc ccaaggccca gaagctgtac ctgacccaca tcgatgccga ggtggaaggc      360

gatacacact tccccgatta cgaacctgac gactgggaaa gcgtgttttc cgaattccac      420

gacgccgacg cccagaacag ccacagctac tgcttcgaga tcctggaaag aagg            474


<210> 74
<211> 405
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 74
atgtacagga tgcagctgct gagctgcatc gccctgagcc tggccctggt gaccaacagc       60

aactgggtga acgtgatctc cgacctgaag aagatcgagg acctgatcca gtccatgcac      120

atcgacgcca ccctgtacac cgagagcgac gtgcacccta gctgcaaggt gaccgccatg      180

aagtgcttcc tgctggagct gcaggtgatc agcctggaga gcggcgatgc cagcatccac      240

gacacagtgg agaacctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      300

accgagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttcctg      360

cagtccttcg tgcacatcgt gcagatgttc atcaacacca gctaa                      405


<210> 75
<211> 912
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 75
atgtacagaa tgcagctgct gagctgcatc gccctgtccc tcgccctggt gaccaactcc       60

gagttctcca ccgagttcat ctccctgatc gccgccctgg ccgtggatta tgtgatcggc      120

atggagaacg ccatgccctg gaatctgccc gccgacctgg cctggttcaa gaggaatacc      180

ctgaacaagc ccgtcatcat gggcaggcac acctgggaaa gcatcggcag acccctgccc      240

ggcaggaaga acatcatcct gtccagccag cccggcaccg acgacagagt gacctgggtg      300

aagagcgtgg acgaagctat cgccgcttgc ggcgacgtgc ccgagatcat ggtgatcggc      360

ggcggcaggg tgatcgaaca gttcctgccc aaggcccaga agctgtacct gacccacatc      420

gatgccgagg tggaaggcga tacacacttc cccgattacg aacctgacga ctgggaaagc      480

gtgttttccg aattccacga cgccgacgcc cagaacagcc acagctactg cttcgagatc      540

ctggaaagaa ggggaggctc cggcggaaac tgggtcaacg tgatcagcga cctgaagaag      600

atcgaggacc tcatccagtc catgcacatt gacgccaccc tgtacaccga gtccgatgtg      660

caccctagct gcaaggtgac cgccatgaaa tgcttcctgc tggagctgca ggtcatctcc      720

ttagaaagcg gcgatgcctc catccacgac accgtggaga acctgatcat cctggccaat      780

aactccctga gcagcaacgg caacgtgacc gagagcggct gcaaagagtg tgaagagctg      840

gaggagaaga acattaagga gttcctgcag agcttcgtgc acatcgtgca aatgttcatc      900

aacaccagct aa                                                          912


<210> 76
<211> 46
<212> PRT
<213> Homo sapiens

<400> 76
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210> 77
<211> 31
<212> PRT
<213> Homo sapiens

<400> 77
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
            20                  25                  30      


<210> 78
<211> 27
<212> PRT
<213> Homo sapiens

<400> 78
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210> 79
<211> 26
<212> PRT
<213> Homo sapiens

<400> 79
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210> 80
<211> 363
<212> PRT
<213> Homo sapiens

<400> 80
Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly 
1               5                   10                  15      


Gly Phe Ile Phe Trp Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu 
            20                  25                  30          


Val Ser Phe Ser Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val 
        35                  40                  45              


Glu Asn Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys 
    50                  55                  60                  


Gly Phe Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln 
65                  70                  75                  80  


Pro Lys Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr 
                85                  90                  95      


Asn Asn Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln 
            100                 105                 110         


Thr His Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr 
        115                 120                 125             


His Ser Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr 
    130                 135                 140                 


Leu Lys Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile 
145                 150                 155                 160 


Ile Met Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu 
                165                 170                 175     


Tyr Trp Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala 
            180                 185                 190         


Met Thr Ser Glu Ile Val Leu Pro Glu Val Val Thr Ile Arg Asp Phe 
        195                 200                 205             


Thr Val Lys Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe 
    210                 215                 220                 


His Phe Thr Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu 
225                 230                 235                 240 


Leu Ile Asn Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro 
                245                 250                 255     


Pro Glu Ser Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr 
            260                 265                 270         


Gly Thr Phe Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu 
        275                 280                 285             


Asn Thr Val Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg 
    290                 295                 300                 


Pro Leu Met Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys 
305                 310                 315                 320 


Val Leu Asp Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile 
                325                 330                 335     


Tyr Gln Asn Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val 
            340                 345                 350         


Thr Thr Phe Gly Lys Thr Asn Gly Tyr Ile Ala 
        355                 360             


<210> 81
<211> 21
<212> PRT
<213> Homo sapiens

<400> 81
Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly 
1               5                   10                  15      


Gly Phe Ile Phe Trp 
            20      


<210> 82
<211> 185
<212> PRT
<213> Homo sapiens

<400> 82
Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210> 83
<211> 106
<212> PRT
<213> Homo sapiens

<400> 83
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Thr His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala His Ile Phe Trp 
    50                  55                  60                  


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
65                  70                  75                  80  


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                85                  90                  95      


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105     


<210> 84
<211> 27
<212> PRT
<213> Homo sapiens

<400> 84
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 85
<211> 66
<212> PRT
<213> Homo sapiens

<400> 85
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210> 86
<211> 33
<212> PRT
<213> Homo sapiens

<400> 86
Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Arg 
    


<210> 87
<211> 68
<212> PRT
<213> Homo sapiens

<400> 87
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210> 88
<211> 28
<212> PRT
<213> Homo sapiens

<400> 88
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210> 89
<211> 26
<212> PRT
<213> Homo sapiens

<400> 89
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe His Phe Trp Val 
            20                  25      


<210> 90
<211> 28
<212> PRT
<213> Homo sapiens

<400> 90
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Gly Gly Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210> 91
<211> 26
<212> PRT
<213> Homo sapiens

<400> 91
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210> 92
<211> 69
<212> PRT
<213> Homo sapiens

<400> 92
Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        35                  40                  45              


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    50                  55                  60                  


Ala Ala Tyr Arg Ser 
65                  


<210> 93
<211> 180
<212> PRT
<213> Homo sapiens

<400> 93
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
65                  70                  75                  80  


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                85                  90                  95      


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            100                 105                 110         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        115                 120                 125             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    130                 135                 140                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
145                 150                 155                 160 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                165                 170                 175     


Leu Pro Pro Arg 
            180 


<210> 94
<211> 216
<212> PRT
<213> Homo sapiens

<400> 94
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
65                  70                  75                  80  


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                85                  90                  95      


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
            100                 105                 110         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        115                 120                 125             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    130                 135                 140                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
145                 150                 155                 160 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                165                 170                 175     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            180                 185                 190         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        195                 200                 205             


His Met Gln Ala Leu Pro Pro Arg 
    210                 215     


<210> 95
<211> 140
<212> PRT
<213> Homo sapiens

<400> 95
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe 
            20                  25                  30          


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        35                  40                  45              


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    50                  55                  60                  


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
65                  70                  75                  80  


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                85                  90                  95      


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            100                 105                 110         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        115                 120                 125             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135                 140 


<210> 96
<211> 222
<212> PRT
<213> Homo sapiens

<400> 96
Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210> 97
<211> 23
<212> PRT
<213> Homo sapiens

<400> 97
Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210> 98
<211> 51
<212> PRT
<213> Homo sapiens

<400> 98
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu 
    50      


<210> 99
<211> 21
<212> PRT
<213> Homo sapiens

<400> 99
Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210> 100
<211> 25
<212> PRT
<213> Homo sapiens

<400> 100
Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210> 101
<211> 22
<212> PRT
<213> Homo sapiens

<400> 101
Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210> 102
<211> 725
<212> PRT
<213> Homo sapiens

<400> 102
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
            20                  25                  30          


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
        35                  40                  45              


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
    50                  55                  60                  


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
65                  70                  75                  80  


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
                85                  90                  95      


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
            100                 105                 110         


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
        115                 120                 125             


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
    130                 135                 140                 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
145                 150                 155                 160 


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
                165                 170                 175     


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
            180                 185                 190         


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
        195                 200                 205             


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
    210                 215                 220                 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
225                 230                 235                 240 


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
            260                 265                 270         


Trp His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
        275                 280                 285             


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
    290                 295                 300                 


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
305                 310                 315                 320 


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
                325                 330                 335     


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
            340                 345                 350         


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
        355                 360                 365             


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
    370                 375                 380                 


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
385                 390                 395                 400 


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
                405                 410                 415     


Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 
            420                 425                 430         


Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 
        435                 440                 445             


Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 
    450                 455                 460                 


Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 
465                 470                 475                 480 


Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln 
                485                 490                 495     


Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu 
            500                 505                 510         


Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu 
        515                 520                 525             


Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr 
    530                 535                 540                 


Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile 
545                 550                 555                 560 


Ser Met Ile Gln Trp Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu 
                565                 570                 575     


Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp 
            580                 585                 590         


Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu 
        595                 600                 605             


Ser Ala Glu Thr Glu Glu Trp Asp Ile Phe Gln Trp Lys Ala Leu Arg 
    610                 615                 620                 


Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln Phe Leu 
625                 630                 635                 640 


Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln Val Lys 
                645                 650                 655     


Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu Val Asp 
            660                 665                 670         


Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala Pro Glu 
        675                 680                 685             


Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro Thr Ser 
    690                 695                 700                 


Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser Pro Ala 
705                 710                 715                 720 


Leu Asn Gln Gly Ser 
                725 


<210> 103
<211> 23
<212> PRT
<213> Homo sapiens

<400> 103
Pro Leu Phe Ile Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu 
1               5                   10                  15      


Ala Phe Ile Ile Trp Leu Ala 
            20              


<210> 104
<211> 24
<212> PRT
<213> Homo sapiens

<400> 104
Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210> 105
<211> 21
<212> PRT
<213> Homo sapiens

<400> 105
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 106
<211> 286
<212> PRT
<213> Homo sapiens

<400> 106
Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  


Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                85                  90                  95      


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            100                 105                 110         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
        115                 120                 125             


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    130                 135                 140                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
145                 150                 155                 160 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                165                 170                 175     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            180                 185                 190         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    210                 215                 220                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
225                 230                 235                 240 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                245                 250                 255     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            260                 265                 270         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 285     


<210> 107
<211> 226
<212> PRT
<213> Homo sapiens

<400> 107
Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
65                  70                  75                  80  


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                85                  90                  95      


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            100                 105                 110         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        115                 120                 125             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    130                 135                 140                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
145                 150                 155                 160 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                165                 170                 175     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            180                 185                 190         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        195                 200                 205             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    210                 215                 220                 


Pro Arg 
225     


<210> 108
<211> 83
<212> PRT
<213> Homo sapiens

<400> 108
Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn 
            


<210> 109
<211> 22
<212> PRT
<213> Homo sapiens

<400> 109
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210> 110
<211> 24
<212> PRT
<213> Homo sapiens

<400> 110
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210> 111
<211> 25
<212> PRT
<213> Homo sapiens

<400> 111
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            20                  25  


<210> 112
<211> 25
<212> PRT
<213> Homo sapiens

<400> 112
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Val Cys Arg 
            20                  25  


<210> 113
<211> 21
<212> PRT
<213> Homo sapiens

<400> 113
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 114
<211> 23
<212> PRT
<213> Homo sapiens

<400> 114
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210> 115
<211> 23
<212> PRT
<213> Homo sapiens

<400> 115
Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210> 116
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 116
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Pro Thr Gly Arg Ser Gly Leu Ala Asp Lys Val Asp Met 
            100                 105                 110         


Ala Arg Ile Val Gly Gly Ser Ser Val Cys Lys Glu Ala Ile Arg Tyr 
        115                 120                 125             


Pro Gly His Pro Lys Leu Pro Val Thr Arg Thr Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Ser Leu Pro Glu Val Ala Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Gly Ala Gln Glu Glu Lys Gly Ala 
                165                 170                 175     


Arg Tyr Lys Phe Glu Ala Tyr Glu Arg Ser Asp 
            180                 185         


<210> 117
<211> 257
<212> PRT
<213> Homo sapiens

<400> 117
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210> 118
<211> 54
<212> PRT
<213> Homo sapiens

<400> 118
Asp Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
1               5                   10                  15      


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
            20                  25                  30          


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
        35                  40                  45              


Asn Pro Lys Asn Asn Arg 
    50                  


<210> 119
<211> 31
<212> PRT
<213> Homo sapiens

<400> 119
Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            20                  25                  30      


<210> 120
<211> 24
<212> PRT
<213> Homo sapiens

<400> 120
Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
1               5                   10                  15      


Val Val Phe Gly Ile Leu Ile Ile 
            20                  


<210> 121
<211> 113
<212> PRT
<213> Homo sapiens

<400> 121
Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly 
1               5                   10                  15      


Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro 
            20                  25                  30          


Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr 
        35                  40                  45              


Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys 
    50                  55                  60                  


Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys 
65                  70                  75                  80  


Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val 
                85                  90                  95      


Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu 
            100                 105                 110         


Ile 
    


<210> 122
<211> 21
<212> PRT
<213> Homo sapiens

<400> 122
Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210> 123
<211> 233
<212> PRT
<213> Homo sapiens

<400> 123
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210> 124
<211> 21
<212> PRT
<213> Homo sapiens

<400> 124
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210> 125
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 125
Met Ala Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Gly Tyr Phe Arg Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Pro Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Arg Asn Asp 
            180                 185         


<210> 126
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 126
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Ser 
1               5                   10                  15      


Val Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Leu Leu Ser Arg Ser Leu Asp Gly 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Glu Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Val Gln Asp Phe Glu 
    130                 135                 140                 


Ser Gly Thr Phe Phe Pro Glu Ile Asp Leu Glu Arg Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 127
<211> 5
<212> PRT
<213> Homo sapiens

<400> 127
Asp Lys Thr His Thr 
1               5   


<210> 128
<211> 4
<212> PRT
<213> Homo sapiens

<400> 128
Cys Pro Pro Cys 
1               


<210> 129
<211> 15
<212> PRT
<213> Homo sapiens

<400> 129
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210> 130
<211> 12
<212> PRT
<213> Homo sapiens

<400> 130
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210> 131
<211> 10
<212> PRT
<213> Homo sapiens

<400> 131
Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210> 132
<211> 7
<212> PRT
<213> Homo sapiens

<400> 132
Lys Cys Cys Val Asp Cys Pro 
1               5           


<210> 133
<211> 7
<212> PRT
<213> Homo sapiens

<400> 133
Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210> 134
<211> 16
<212> PRT
<213> Homo sapiens

<400> 134
Val Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210> 135
<211> 16
<212> PRT
<213> Homo sapiens

<400> 135
Leu Asp Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210> 136
<211> 39
<212> PRT
<213> Homo sapiens

<400> 136
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210> 137
<211> 12
<212> PRT
<213> Homo sapiens

<400> 137
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
1               5                   10          


<210> 138
<211> 45
<212> PRT
<213> Homo sapiens

<400> 138
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 139
<211> 48
<212> PRT
<213> Homo sapiens

<400> 139
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210> 140
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 140
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Leu Gln Gly Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Ala Arg Pro Ser Glu Gly Gly Ile Asn Leu Val Leu Ser Arg Glu Pro 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Gly Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Asp Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Pro Lys Leu Phe Val Thr Arg Val Ile Gln Gly Phe Glu 
    130                 135                 140                 


Ser Gly Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Gly Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Gly 
            180                 185         


<210> 141
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 141
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Asn Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Ser Arg Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Thr 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Gly Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Gly Tyr Pro Gly Val Leu Ser Asp Val Gln Gly Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 142
<211> 79
<212> PRT
<213> Homo sapiens

<400> 142
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Glu Pro Lys 
        35                  40                  45              


Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
    50                  55                  60                  


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
65                  70                  75                  


<210> 143
<211> 51
<212> PRT
<213> Homo sapiens

<400> 143
Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
1               5                   10                  15      


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            20                  25                  30          


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  45              


Asp Ile Tyr 
    50      


<210> 144
<211> 69
<212> PRT
<213> Homo sapiens

<400> 144
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210> 145
<211> 44
<212> PRT
<213> Homo sapiens

<400> 145
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
1               5                   10                  15      


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            20                  25                  30          


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  


<210> 146
<211> 47
<212> PRT
<213> Homo sapiens

<400> 146
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210> 147
<211> 11
<212> PRT
<213> Homo sapiens

<400> 147
Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10      


<210> 148
<211> 101
<212> PRT
<213> Homo sapiens

<400> 148
Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val 
1               5                   10                  15      


Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile 
            20                  25                  30          


Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln 
        35                  40                  45              


Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu 
    50                  55                  60                  


Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu 
65                  70                  75                  80  


Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu 
                85                  90                  95      


Leu Thr Pro Ser Asp 
            100     


<210> 149
<211> 16
<212> PRT
<213> Homo sapiens

<400> 149
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210> 150
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 150
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Gly Ile Met Gln Gly Ser Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Arg Tyr Glu Leu Leu 
145                 150                 155                 160 


Pro Gly Tyr Pro Gly Ala Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Glu Cys Lys Phe Glu Val Tyr Glu Glu Ser Asp 
            180                 185         


<210> 151
<211> 282
<212> PRT
<213> Homo sapiens

<400> 151
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 152
<211> 246
<212> PRT
<213> Homo sapiens

<400> 152
Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys Lys Asp Pro Lys 
                245     


<210> 153
<211> 45
<212> PRT
<213> Homo sapiens

<400> 153
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        35                  40                  45  


<210> 154
<211> 16
<212> PRT
<213> Homo sapiens

<400> 154
Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210> 155
<211> 43
<212> PRT
<213> Homo sapiens

<400> 155
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        35                  40              


<210> 156
<211> 15
<212> PRT
<213> Homo sapiens

<400> 156
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 157
<211> 16
<212> PRT
<213> Homo sapiens

<400> 157
Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


<210> 158
<211> 15
<212> PRT
<213> Homo sapiens

<400> 158
Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210> 159
<211> 12
<212> PRT
<213> Homo sapiens

<400> 159
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210> 160
<211> 12
<212> PRT
<213> Homo sapiens

<400> 160
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210> 161
<211> 229
<212> PRT
<213> Homo sapiens

<400> 161
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 162
<211> 119
<212> PRT
<213> Homo sapiens

<400> 162
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210> 163
<211> 282
<212> PRT
<213> Homo sapiens

<400> 163
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 164
<211> 281
<212> PRT
<213> Homo sapiens

<400> 164
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu His Pro Ser Leu Pro Pro Gln 
145                 150                 155                 160 


Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys Leu 
                165                 170                 175     


Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser Trp 
            180                 185                 190         


Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu Met 
        195                 200                 205             


Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro Ala 
    210                 215                 220                 


Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser Val 
225                 230                 235                 240 


Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr Cys 
                245                 250                 255     


Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg Ser 
            260                 265                 270         


Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280     


<210> 165
<211> 283
<212> PRT
<213> Homo sapiens

<400> 165
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Val Val Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
    210                 215                 220                 


Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp 
225                 230                 235                 240 


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
                245                 250                 255     


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
            260                 265                 270         


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280             


<210> 166
<211> 58
<212> PRT
<213> Homo sapiens

<400> 166
Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210> 167
<211> 282
<212> PRT
<213> Homo sapiens

<400> 167
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 168
<211> 282
<212> PRT
<213> Homo sapiens

<400> 168
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 169
<211> 282
<212> PRT
<213> Homo sapiens

<400> 169
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 170
<211> 282
<212> PRT
<213> Homo sapiens

<400> 170
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210> 171
<211> 234
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (91)..(91)
<223> Selenocysteine

<400> 171
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Xaa Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210> 172
<211> 234
<212> PRT
<213> Homo sapiens

<400> 172
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210> 173
<211> 20
<212> PRT
<213> Homo sapiens

<400> 173
Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210> 174
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 174
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Arg Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Arg Pro Thr Gly Gln Pro Glu Leu Ala Asp Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Arg Glu Ala Met Asn Arg 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Gly Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Leu Glu Val Tyr Glu Glu Asn Asp 
            180                 185         


<210> 175
<211> 233
<212> PRT
<213> Homo sapiens

<400> 175
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Val Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210> 176
<211> 13
<212> PRT
<213> Homo sapiens

<400> 176
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10              


<210> 177
<211> 231
<212> PRT
<213> Homo sapiens

<400> 177
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 178
<211> 235
<212> PRT
<213> Homo sapiens

<400> 178
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235 


<210> 179
<211> 223
<212> PRT
<213> Homo sapiens

<400> 179
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210> 180
<211> 235
<212> PRT
<213> Homo sapiens

<400> 180
Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235 


<210> 181
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 181
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Ser Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Ser Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Leu Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Thr Gly Lys Glu Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Gly Gly Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Ser Tyr 
        115                 120                 125             


Pro Gly His Leu Lys Leu Leu Val Thr Arg Ile Met Gln Asp Ser Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Pro Pro 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Ala Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Leu Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 182
<211> 17
<212> PRT
<213> Homo sapiens

<400> 182
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210> 183
<211> 61
<212> PRT
<213> Homo sapiens

<400> 183
Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210> 184
<211> 230
<212> PRT
<213> Homo sapiens

<400> 184
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210> 185
<211> 230
<212> PRT
<213> Homo sapiens

<400> 185
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210> 186
<211> 12
<212> PRT
<213> Homo sapiens

<400> 186
Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210> 187
<211> 107
<212> PRT
<213> Homo sapiens

<400> 187
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210> 188
<211> 129
<212> PRT
<213> Homo sapiens

<400> 188
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            20                  25                  30          


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        35                  40                  45              


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    50                  55                  60                  


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
65                  70                  75                  80  


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            100                 105                 110         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        115                 120                 125             


Lys 
    


<210> 189
<211> 229
<212> PRT
<213> Homo sapiens

<400> 189
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Val Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 190
<211> 229
<212> PRT
<213> Homo sapiens

<400> 190
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Val Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 191
<211> 230
<212> PRT
<213> Homo sapiens

<400> 191
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210> 192
<211> 36
<212> PRT
<213> Homo sapiens

<400> 192
Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys Gly Gly Ala Cys 
1               5                   10                  15      


Cys Gly Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Thr Thr Gly 
            20                  25                  30          


Cys Cys Cys Thr 
        35      


<210> 193
<211> 12
<212> PRT
<213> Homo sapiens

<400> 193
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210> 194
<211> 119
<212> PRT
<213> Homo sapiens

<400> 194
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210> 195
<211> 229
<212> PRT
<213> Homo sapiens

<400> 195
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 196
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 196
Met Ala Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Val Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asp Gly Phe 
            20                  25                  30          


Arg Tyr Phe Arg Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Ser Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Glu Gly Arg Thr Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala Tyr Leu Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asp Glu Ala Gly Met 
            100                 105                 110         


Val Trp Val Val Gly Gly Ser Ser Val Asp Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Pro Lys Leu Ser Val Thr Arg Ile Val Gln Asp Phe Gly 
    130                 135                 140                 


Ser Asp Ala Phe Phe Pro Glu Ile Asp Leu Glu Lys Cys Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Ala Gln Glu Glu Arg Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Ser Asp 
            180                 185         


<210> 197
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 197
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Pro Arg His Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Val Thr Thr Thr Ser Ser Ala Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Ser Lys Gly Arg Ile Gly Leu Val Leu Ser Gly Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Thr Leu Arg Leu Thr Glu Gln Pro Glu Leu Thr Asn Arg Val Asn Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Arg Pro Val Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Ala Phe Phe Pro Glu Val Asp Leu Glu Lys Tyr Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Gly Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Ala Tyr Arg Lys Asn Asp 
            180                 185         


<210> 198
<211> 9
<212> PRT
<213> Homo sapiens

<400> 198
Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   


<210> 199
<211> 10
<212> PRT
<213> Homo sapiens

<400> 199
Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210> 200
<211> 13
<212> PRT
<213> Homo sapiens

<400> 200
Glu Val Val Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10              


<210> 201
<211> 229
<212> PRT
<213> Homo sapiens

<400> 201
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Leu Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 202
<211> 22
<212> PRT
<213> Homo sapiens

<400> 202
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly 
            20          


<210> 203
<211> 231
<212> PRT
<213> Homo sapiens

<400> 203
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Ile Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 204
<211> 231
<212> PRT
<213> Homo sapiens

<400> 204
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Leu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Ile Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210> 205
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 205
Met Val Gly Ser Leu Asn Cys Ile Val Thr Val Ser Arg Ser Met Gly 
1               5                   10                  15      


Ile Gly Lys Asp Gly Asp Leu Ser Trp Pro Pro Leu Arg Ser Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Thr Thr Ala Thr Ser Ser Val Glu Gly Arg Gln 
        35                  40                  45              


Ser Leu Val Ile Met Gly Lys Arg Thr Trp Phe Ser Thr Pro Glu Arg 
    50                  55                  60                  


Asn Arg Pro Leu Arg Gly Arg Ala Asn Leu Val Leu Ser Gly Glu Leu 
65                  70                  75                  80  


Lys Gly Pro Pro Gln Gly Ala His Leu Leu Ser Arg Ser Leu Asp Gly 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asp Lys Val Asp Val 
            100                 105                 110         


Val Arg Ile Val Gly Gly Ser Ser Val Asp Glu Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Val Met Arg Gly Phe Glu 
    130                 135                 140                 


Ser Asp Thr Leu Phe Pro Gly Ile Asp Leu Gly Lys Arg Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Arg Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Leu Glu Val Cys Gly Asn Asn 
            180                 185     


<210> 206
<211> 68
<212> PRT
<213> Homo sapiens

<400> 206
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
1               5                   10                  15      


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            20                  25                  30          


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        35                  40                  45              


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    50                  55                  60                  


Thr Leu Tyr Cys 
65              


<210> 207
<211> 243
<212> PRT
<213> Homo sapiens

<400> 207
Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Ser 
    130                 135                 140                 


Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Ser Val His Trp Val Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Gly 
                165                 170                 175     


Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asn Glu Gly Asp Thr 
    210                 215                 220                 


Thr Ala Gly Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210> 208
<211> 62
<212> PRT
<213> Homo sapiens

<400> 208
Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe 
1               5                   10                  15      


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            20                  25                  30          


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        35                  40                  45              


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    50                  55                  60          


<210> 209
<211> 68
<212> PRT
<213> Homo sapiens

<400> 209
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr 
65              


<210> 210
<211> 70
<212> PRT
<213> Homo sapiens

<400> 210
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr 
65                  70  


<210> 211
<211> 267
<212> PRT
<213> Homo sapiens

<400> 211
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210> 212
<211> 234
<212> PRT
<213> Homo sapiens

<400> 212
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Lys Pro 
                85                  90                  95      


Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala 
            100                 105                 110         


Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly 
        115                 120                 125             


Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln 
    130                 135                 140                 


Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro 
145                 150                 155                 160 


Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser 
                165                 170                 175     


Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala 
            180                 185                 190         


Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met 
        195                 200                 205             


Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp 
    210                 215                 220                 


Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 


<210> 213
<211> 231
<212> PRT
<213> Homo sapiens

<400> 213
Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
    50                  55                  60                  


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
                85                  90                  95      


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
            100                 105                 110         


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
        115                 120                 125             


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
    130                 135                 140                 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
145                 150                 155                 160 


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
                165                 170                 175     


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
            180                 185                 190         


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
        195                 200                 205             


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
    210                 215                 220                 


Glu Asn Cys Ser His His Leu 
225                 230     


<210> 214
<211> 353
<212> PRT
<213> Homo sapiens

<400> 214
Met Arg Leu Ala Gly Arg Gln Val Pro Glu Gln Arg Ser Pro Pro Pro 
1               5                   10                  15      


Pro Gly Leu Gly Ser Ala Arg Pro Gly Ser Pro Ala Val Ser Cys Gly 
            20                  25                  30          


Ala Ala Ala Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly 
        35                  40                  45              


Leu Pro Ala Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg 
    50                  55                  60                  


Asp Ala Arg Asp Arg Leu Ala Val Leu Ala Gly Arg Ser Arg Ile Ser 
65                  70                  75                  80  


Glu Ser Phe Asn His Glu Val Gln Thr His Glu Ala Cys Val Arg Leu 
                85                  90                  95      


Arg Thr Met Glu Asn Cys Pro Gln Cys His His His Arg Thr Ser Arg 
            100                 105                 110         


Gln Gln Ala Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        115                 120                 125             


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    130                 135                 140                 


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
145                 150                 155                 160 


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                165                 170                 175     


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
            180                 185                 190         


Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu 
        195                 200                 205             


Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn 
    210                 215                 220                 


Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro 
225                 230                 235                 240 


Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser 
                245                 250                 255     


Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr 
            260                 265                 270         


Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser 
        275                 280                 285             


Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu 
    290                 295                 300                 


Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro 
305                 310                 315                 320 


Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr 
                325                 330                 335     


Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His 
            340                 345                 350         


Leu 
    


<210> 215
<211> 61
<212> PRT
<213> Homo sapiens

<400> 215
Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60      


<210> 216
<211> 237
<212> PRT
<213> Homo sapiens

<400> 216
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210> 217
<211> 175
<212> PRT
<213> Homo sapiens

<400> 217
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210> 218
<211> 65
<212> PRT
<213> Homo sapiens

<400> 218
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210> 219
<211> 18
<212> PRT
<213> Homo sapiens

<400> 219
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210> 220
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 220
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
            20                  25      


<210> 221
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 221
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 222
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 222
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Phe 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 223
<211> 555
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 223
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp His Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Tyr 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Lys Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210> 224
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Gly Val Gln 
385                 390                 395                 400 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
                405                 410                 415     


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys 
            420                 425                 430         


Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
        435                 440                 445             


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
    450                 455                 460                 


Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
465                 470                 475                 480 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                485                 490                 495     


Asp Val Glu Leu Leu Glu Leu Glu 
            500                 


<210> 225
<211> 395
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 225
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
385                 390                 395 


<210> 226
<211> 555
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 226
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210> 227
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 227
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210> 228
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 228
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Phe 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Phe Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210> 229
<211> 54
<212> DNA
<213> Homo sapiens

<400> 229
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagc             54


<210> 230
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 230
tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca       60

ggaggaggga gcttgcaa                                                     78


<210> 231
<211> 714
<212> DNA
<213> Homo sapiens

<400> 231
atcacgtgcc ctccccccat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc       60

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      120

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      180

ctcaaatgca ttagagaccc tgccctggtt caccaaaggc cagcgccacc ctccacagta      240

acgacggcag gggtgacccc acagccagag agcctctccc cttctggaaa agagcccgca      300

gcttcatctc ccagctcaaa caacacagcg gccacaacag cagctattgt cccgggctcc      360

cagctgatgc cttcaaaatc accttccaca ggaaccacag agataagcag tcatgagtcc      420

tcccacggca ccccctctca gacaacagcc aagaactggg aactcacagc atccgcctcc      480

caccagccgc caggtgtgta tccacagggc cacagcgaca ccactgtggc tatctccacg      540

tccactgtcc tgctgtgtgg gctgagcgct gtgtctctcc tggcatgcta cctcaagtca      600

aggcaaactc ccccgctggc cagcgttgaa atggaagcca tggaggctct gccggtgact      660

tgggggacca gcagcagaga tgaagacttg gaaaactgct ctcaccacct atga            714


<210> 232
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 232
attacctgcc cccctccgat gagcgtggag cacgccgaca tctgggtcaa gagctacagc       60

ttgtatagta gggagcggta catctgtaac agcgggttca agaggaaggc cgggaccagc      120

tcactgaccg agtgcgtgtt gaacaaggcc accaacgtgg cccactggac cacccctagc      180

cttaagtgca tcagggaccc agcgctcgta caccagagac ccgcgcctcc ctctacggta      240

accacggcag gcgtaacccc ccagcccgag agcctgtccc cgagcggcaa ggagcctgca      300

gcgagcagcc cctcaagcaa caacacagcc gctaccaccg cggcaatcgt gcccggcagc      360

cagctgatgc cctcaaagag ccccagcacc ggcaccactg agataagcag ccacgagagc      420

tcacacggca ctccctcaca gaccactgcc aagaattggg agctgaccgc ctctgccagc      480

caccagcccc caggcgtgta tccccagggc cacagcgaca ccacggtcgc catcagcaca      540

tctacagtgc ttttgtgcgg ccttagcgcc gtgtcactgc tggcatgcta cttgaaaagt      600

aggcaaactc cccctcttgc cagtgtggaa atggaggcca tggaagccct gcccgtgacc      660

tggggcacca gttctaggga cgaggacctt gagaactgct cacatcattt g               711


<210> 233
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 233
atctctctga ttgcggcgct ggcagttgac tacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgttatcgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta cgaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgttga         477


<210> 234
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 234
atctctctga ttgcggcgct ggcagttgac cacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgtttacgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta caaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgttga         477


<210> 235
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 235
ggcgtgcagg tggagacaat cagccccggc gatggccgga cctttcctaa gagaggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctccagg      120

gatcgcaata agcccttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgacaatctc tccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210> 236
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 236
ggagtgcagg tggagacaat cagccccggc gatggcagga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctcccgg      120

gatagaaata agcccttcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag ggcgccaagc tgacaatcag cccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210> 237
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 237
ggcgtgcagg tggagacaat cagccccggc gatggccgga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctccagg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgacaatctc tccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210> 238
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 238
ggagtgcagg tggagacaat cagcccaggc gacggaagga cattcccaaa gaggggacag       60

acctgcgtgg tgcactacac aggcatgctg ggcgatggca agaaggtgga cagctcccgg      120

gatagaaaca agcccttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgaccatctc tcctgactac      240

gcctatggag caacaggaca cccaggaatc atcccacctc acgccaccct ggtgtttgat      300

gtggagctgc tggagctgga gtga                                             324


<210> 239
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 239
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttcagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagt tcatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgattg a                                                561


<210> 240
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 240
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttttcaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaagt tccgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgattg a                                                561


<210> 241
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 241
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg catctctctg     1200

attgcggcgc tggcagttga ccacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgtttacga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acaaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttga                  1668


<210> 242
<211> 1515
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 242
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cggcgtgcag     1200

gttgagacta taagcccagg cgacggcagg accttcccca agaggggcca gacatgcgtg     1260

gtgcactaca ccggcatgct tggcgacggc aaaaaggtgg actcaagcag ggacaggaac     1320

aagcccttca agttcatgtt gggcaaacag gaggtgatca gaggctggga ggagggtgtt     1380

gcccagatga gcgtggggca gggcgccaag ctcacgataa gtcccgatta cgcctacggc     1440

gccaccggtc accccggcat catcccccca cacgccaccc tggtgttcga cgtggaattg     1500

ctggagctgg agtga                                                      1515


<210> 243
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 243
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgtga                  1188


<210> 244
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 244
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg catctctctg     1200

attgcggcgc tggcagttga ctacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgttatcga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acgaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttga                  1668


<210> 245
<211> 1752
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 245
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt tattaaggaa     1560

ttcatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210> 246
<211> 1752
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 246
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttcttcagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

ttccgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt tattaaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210> 247
<211> 22
<212> PRT
<213> Homo sapiens

<400> 247
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala 
            20          


<210> 248
<211> 66
<212> DNA
<213> Homo sapiens

<400> 248
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggcc                                                                  66


<210> 249
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 249
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atcccctctg       60

gtggca                                                                  66


<210> 250
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 250
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc cagccctctg       60

gtggcc                                                                  66


<210> 251
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 251
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc aagccctctg       60

gtggca                                                                  66


<210> 252
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 252
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atccccactg       60

gtggca                                                                  66


<210> 253
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 253
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggcc                                                                  66


<210> 254
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 254
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc ctcccccctg       60

gtggcc                                                                  66


<210> 255
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 255
atgtgccacc agcagctggt catctcctgg ttctctctgg tgtttctggc atctcctctg       60

gtggca                                                                  66


<210> 256
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 256
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc atccccactg       60

gtggca                                                                  66


<210> 257
<211> 21
<212> PRT
<213> Homo sapiens

<400> 257
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 258
<211> 63
<212> DNA
<213> Homo sapiens

<400> 258
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210> 259
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 259
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccc                                                                     63


<210> 260
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 260
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cct                                                                     63


<210> 261
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 261
atggcactgc ctgtgacagc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cct                                                                     63


<210> 262
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 262
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cct                                                                     63


<210> 263
<211> 9
<212> PRT
<213> Homo sapiens

<400> 263
Ser Ala Arg Asn Arg Gln Lys Arg Ser 
1               5                   


<210> 264
<211> 27
<212> DNA
<213> Homo sapiens

<400> 264
agcgccagga atcgccagaa gcggtcc                                           27


<210> 265
<211> 8
<212> PRT
<213> Homo sapiens

<400> 265
Ala Arg Asn Arg Gln Lys Arg Ser 
1               5               


<210> 266
<211> 24
<212> DNA
<213> Homo sapiens

<400> 266
gcccggaata gacagaagag atct                                              24


<210> 267
<211> 12
<212> PRT
<213> Homo sapiens 

<400> 267
Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys 
1               5                   10          


<210> 268
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cleavage site

<400> 268
gagtctaggc gcgtgcggag aaataagcgg agcaag                                 36


<210> 269
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cleavage site

<400> 269
gagtctcgga gagtgaggcg caataagagg agcaag                                 36


<210> 270
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      cleavage site

<400> 270
gagtccagga gagtgcggcg caacaagagg agcaag                                 36


<210> 271
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 271
Gly Gly Ser Gly 
1               


<210> 272
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 272
ggaggatctg ga                                                           12


<210> 273
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 273
Gly Gly Ser Gly Gly Gly 
1               5       


<210> 274
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 274
ggtggctctg gtggtggt                                                     18


<210> 275
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 275
ggaggtagtg gtggaggc                                                     18


<210> 276
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 276
Ser Gly Gly Gly Ser 
1               5   


<210> 277
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 277
tcaggtggcg gtagt                                                        15


<210> 278
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 278
Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   


<210> 279
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 279
ggaggtagtg gtggaggcag tggtgga                                           27


<210> 280
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 280
Gly Gly Gly Gly Gly 
1               5   


<210> 281
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 281
Gly Gly Gly Gly Ser 
1               5   


<210> 282
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 282
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 283
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 283
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 284
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 284
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 285
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 285
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 286
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 286
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 287
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 287
Ser Ser Ser Ser Gly 
1               5   


<210> 288
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 288
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10  


<210> 289
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 289
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10                  15  


<210> 290
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 290
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly 
            20  


<210> 291
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 291
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Gly 
            20                  25  


<210> 292
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 292
Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
            20                  25                  30  


<210> 293
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 293
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 294
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 294
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttcaagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 295
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 295
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattacgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aatcatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 296
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 296
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

acggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 297
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 297
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaata acgttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 298
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 298
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tatttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 299
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 299
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtg cagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacgc gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 300
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 300
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gctattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 301
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 301
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aattcatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 302
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 302
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttcaagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agttccgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 303
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 303
gtgggcagcc tgaactgtat cgtggccgtg tcccagaaca tgggcatcgg caagaatggc       60

gatctgccat ggccccctct gcggaacgag ttcagatact tctttaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacctg gttttctatc      180

cccgagaaga acagacctct gaagggcagg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgaca      300

gagcagccag agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagt ttatgaatca ccccggccac ctgaagctgt tcgtgaccag aatcatgcag      420

gactttgagt ccgatacatt ctttcctgag atcgatctgg agaagtacaa gctgctgcca      480

gagtatcccg gcgtgctgtc tgacgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaacgat                                                    558


<210> 304
<211> 311
<212> PRT
<213> Renilla reniformis

<400> 304
Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln 
305                 310     


<210> 305
<211> 936
<212> DNA
<213> Renilla reniformis

<400> 305
atgacttcca aggtgtacga ccccgagcaa cgcaaacgca tgatcactgg gcctcagtgg       60

tgggctcgct gcaagcaaat gaacgtgctg gactccttca tcaactacta tgattccgag      120

aagcacgccg agaacgccgt gatttttctg catggtaacg ctgcctccag ctacctgtgg      180

aggcacgtcg tgcctcacat cgagcccgtg gctagatgca tcatccctga tctgatcgga      240

atgggtaagt ccggcaagag cgggaatggc tcatatcgcc tcctggatca ctacaagtac      300

ctcaccgctt ggttcgagct gctgaacctt ccaaagaaaa tcatctttgt gggccacgac      360

tggggggctt gtctggcctt tcactactcc tacgagcacc aagacaagat caaggccatc      420

gtccatgctg agagtgtcgt ggacgtgatc gagtcctggg acgagtggcc tgacatcgag      480

gaggatatcg ccctgatcaa gagcgaagag ggcgagaaaa tggtgcttga gaataacttc      540

ttcgtcgaga ccatgctccc aagcaagatc atgcggaaac tggagcctga ggagttcgct      600

gcctacctgg agccattcaa ggagaagggc gaggttagac ggcctaccct ctcctggcct      660

cgcgagatcc ctctcgttaa gggaggcaag cccgacgtcg tccagattgt ccgcaactac      720

aacgcctacc ttcgggccag cgacgatctg cctaagatgt tcatcgagtc cgaccctggg      780

ttcttttcca acgctattgt cgagggagct aagaagttcc ctaacaccga gttcgtgaag      840

gtgaagggcc tccacttcag ccaggaggac gctccagatg aaatgggtaa gtacatcaag      900

agcttcgtgg agcgcgtgct gaagaacgag cagtaa                                936


<210> 306
<211> 550
<212> PRT
<213> Photinus pyralis

<400> 306
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ser Lys Leu 
545                 550 


<210> 307
<211> 1653
<212> DNA
<213> Photinus pyralis

<400> 307
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg       60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc      120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc      180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg      240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg      300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc      360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa      420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc      480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac      540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc      600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt      660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg      720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt      780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat      840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc      900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc      960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac     1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc     1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag     1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc     1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc     1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc     1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa     1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg     1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac     1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac     1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt     1620

aaggccaaga agggcggcaa gagcaagctg tga                                  1653


<210> 308
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 308
Met Val Ser Lys Gly Ala Glu Leu Phe Thr Gly Ile Val Pro Ile Leu 
1               5                   10                  15      


Ile Glu Leu Asn Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Glu Asp Asp Gly Asn Tyr Lys Ser Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Thr Gly 
        115                 120                 125             


Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly Asn Lys Met Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ala His Asn Val Tyr Ile Met Thr Asp Lys Ala Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Ile Tyr Phe Gly Phe 
    210                 215                 220                 


Val Thr Ala Ala Ala Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 309
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 309
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser 
        


<210> 310
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 310
agcggcggtg gcagc                                                        15


<210> 311
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 311
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210> 312
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 312
Gly Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  15  


<210> 313
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 313
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Ser Glu Gly Ser Gly Ser 
1               5                   10                  15      


Thr Lys Gly 
            


<210> 314
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 314
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 315
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 315
Val Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Asp 
1               5                   10              


<210> 316
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 316
gtcgactatc cctacgatgt tccggactac gcactggac                              39


<210> 317
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 317
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210> 318
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 318
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 319
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 319
ggaggaggag gatccggagg aggaggatct ggcggcggcg gcagc                       45


<210> 320
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 320
ggaggaggag gatccggagg aggaggatct ggcggaggag gcagc                       45


<210> 321
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 321
ggaggaggag gaagcggagg aggaggatcc ggcggaggag gctct                       45


<210> 322
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 322
ggaggaggag gcagcggagg aggaggttct ggaggaggcg gcagc                       45


<210> 323
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 323
ggcggcggcg gctctggagg aggaggcagc ggcggaggag gctcc                       45


<210> 324
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 324
ggaggaggag gcagcggcgg aggaggctcc ggcggcggcg gctct                       45


<210> 325
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 325
ggagtgcagg tggagacaat ctctcctggc gatggccgga ccttcccaaa gagaggccag       60

acatgcgtgg tgcactacac cggcatgctg gaggacggca agaaggtgga cagctcccgg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc tgtgggccag agagccaagc tgacaatcag ccctgattac      240

gcatatggag caaccggaca cccaggaatc atcccacctc acgccaccct ggtgtttgat      300

gtggagctgc tgaagccaga g                                                321


<210> 326
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 326
ggagtgcagg tggagacaat ctcccctggc gatggcagga ccttcccaaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg gaggacggca agaaggtgga cagctcccgg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag cgcgccaagc tgacaatctc tcctgattac      240

gcatatggag caaccggaca cccaggaatc atcccacctc acgccaccct ggtgtttgac      300

gtggagctgc tgaagcccga g                                                321


<210> 327
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 327
ggcgtgcagg tggagacaat cagcccaggc gacggacgca cctttccaaa gaggggacag       60

acatgcgtgg tgcactacac cggcatgctg gaggatggca agaaggtgga ctcctctaga      120

gatcggaata agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag cgggccaagc tgacaatcag ccctgactat      240

gcatacggag caaccggaca cccaggaatc atcccaccac acgccacact ggtgttcgat      300

gtggagctgc tgaagcctga g                                                321


<210> 328
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 328
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 329
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 329
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Ile Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 330
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 330
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Tyr His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 331
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 331
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 332
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 332
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Ser Leu Pro Trp Pro Pro Leu Arg Asn Glu Met Ser 
            20                  25                  30          


Tyr Phe Ser Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Ser 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 333
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 333
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Asp Met Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Ile Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 334
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 334
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Gly Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 335
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 335
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Glu Asn Asp 
            180                 185     


<210> 336
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 336
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 337
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 337
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Phe 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 338
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 338
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 339
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 339
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 340
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 340
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 341
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 341
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210> 342
<211> 1335
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      promoter

<400> 342
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtga                                                      1335


<210> 343
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 343
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210> 344
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 344
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210> 345
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HA Tag

<400> 345
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 346
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HA Tag

<400> 346
tacccatacg atgttccaga ttacgct                                           27


<210> 347
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      HA Tag

<400> 347
tatccttacg atgtgcccga ctatgct                                           27


<210> 348
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 348
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asn Trp Val Asn Val 
            20                  25                  30          


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
        35                  40                  45              


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
    50                  55                  60                  


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
65                  70                  75                  80  


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
                85                  90                  95      


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
            100                 105                 110         


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
        115                 120                 125             


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Ser 
    130                 135                 140             


<210> 349
<211> 432
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 349
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagctaccca       60

tacgatgttc cagattacgc taactgggtg aacgtgatct ccgacctgaa aaagatcgag      120

gatttgatcc agagcatgca cattgacgcc accctgtata ccgagtccga cgtgcacccg      180

agttgcaagg tgactgccat gaagtgcttc ctgctggagc tgcaagtgat cagcctggag      240

agcggcgacg ccagcatcca cgacaccgtg gaaaacctta tcattctggc caacaatagc      300

ctgagcagca acggcaacgt gaccgaaagc ggatgtaagg aatgcgagga actggaagag      360

aagaatatca aagaattcct gcaaagcttc gtgcacatcg tgcagatgtt catcaacact      420

tctggatcct ga                                                          432


<210> 350
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Cleavable peptide

<400> 350
Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 351
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Cleavable peptide

<400> 351
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct       60


<210> 352
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 352
Leu Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210> 353
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 353
ttgagcaagg gcgaggagga caacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggcggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgccgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagctgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgagcgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210> 354
<211> 389
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 354
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    130                 135                 140                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Leu Ser Lys Gly Glu Glu 
145                 150                 155                 160 


Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met 
                165                 170                 175     


Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu 
            180                 185                 190         


Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys 
        195                 200                 205             


Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met 
    210                 215                 220                 


Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr 
225                 230                 235                 240 


Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn 
                245                 250                 255     


Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln 
            260                 265                 270         


Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro 
        275                 280                 285             


Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser 
    290                 295                 300                 


Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys 
305                 310                 315                 320 


Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys 
                325                 330                 335     


Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn 
            340                 345                 350         


Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile 
        355                 360                 365             


Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met 
    370                 375                 380                 


Asp Glu Leu Tyr Lys 
385                 


<210> 355
<211> 1170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 355
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat ccggagctac taacttcagc      420

ctgctgaagc aggctggaga cgtggaggag aaccctggac ctttgagcaa gggcgaggag      480

gacaacatgg ccatcatcaa ggagttcatg cgcttcaagg tgcacatgga gggctccgtg      540

aacggccacg agttcgagat cgagggcgag ggcgagggcc gcccctacga gggcacccag      600

accgccaagc tgaaggtgac caagggcggc cccctgccct tcgcctggga catcctgtcc      660

cctcagttca tgtacggctc caaggcctac gtgaagcacc ccgccgacat ccccgactac      720

ttgaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt cgaggacggc      780

ggcgtggtga ccgtgaccca ggactcctcc ctgcaggacg gcgagttcat ctacaaggtg      840

aagctgcgcg gcaccaactt cccctccgac ggccccgtaa tgcagaagaa gaccatgggc      900

tgggaggcct cctccgagcg gatgtacccc gaggacggcg ccctgaaggg cgagatcaag      960

cagaggctga agctgaagga cggcggccac tacgacgccg aggtcaagac cacctacaag     1020

gccaagaagc ccgtgcagct gcccggcgcc tacaacgtca acatcaagct ggacatcacc     1080

tcccacaacg aggactacac catcgtggaa cagtacgagc gcgccgaggg ccgccactcc     1140

accggcggca tggacgagct gtacaagtaa                                      1170


<210> 356
<211> 577
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 356
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Val Gly Ser Leu Asn Cys Ile Val Ala Val 
    130                 135                 140                 


Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro 
145                 150                 155                 160 


Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser 
                165                 170                 175     


Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe 
            180                 185                 190         


Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val 
        195                 200                 205             


Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser 
    210                 215                 220                 


Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala 
225                 230                 235                 240 


Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys 
                245                 250                 255     


Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile 
            260                 265                 270         


Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu 
        275                 280                 285             


Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln 
    290                 295                 300                 


Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
305                 310                 315                 320 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                325                 330                 335     


Glu Glu Asn Pro Gly Pro Leu Ser Lys Gly Glu Glu Asp Asn Met Ala 
            340                 345                 350         


Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val 
        355                 360                 365             


Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr 
    370                 375                 380                 


Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu 
385                 390                 395                 400 


Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys 
                405                 410                 415     


Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser 
            420                 425                 430         


Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly 
        435                 440                 445             


Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe 
    450                 455                 460                 


Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro 
465                 470                 475                 480 


Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met 
                485                 490                 495     


Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys 
            500                 505                 510         


Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys 
        515                 520                 525             


Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys 
    530                 535                 540                 


Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr 
545                 550                 555                 560 


Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr 
                565                 570                 575     


Lys 
    


<210> 357
<211> 1734
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 357
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

ggatccggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct     1020

ggacctttga gcaagggcga ggaggacaac atggccatca tcaaggagtt catgcgcttc     1080

aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag     1140

ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg cggccccctg     1200

cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag     1260

caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag     1320

cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag     1380

gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc     1440

gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac     1500

ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac     1560

gccgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac     1620

gtcaacatca agctggacat cacctcccac aacgaggact acaccatcgt ggaacagtac     1680

gagcgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaa           1734


<210> 358
<211> 21
<212> PRT
<213> Homo sapiens

<400> 358
Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210> 359
<211> 68
<212> PRT
<213> Homo sapiens

<400> 359
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210> 360
<211> 106
<212> PRT
<213> Homo sapiens

<400> 360
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Trp Val Gly Gly Val 
        35                  40                  45              


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    50                  55                  60                  


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
65                  70                  75                  80  


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                85                  90                  95      


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105     


<210> 361
<211> 28
<212> PRT
<213> Homo sapiens

<400> 361
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210> 362
<211> 71
<212> PRT
<213> Homo sapiens

<400> 362
Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45              


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    50                  55                  60                  


Val Ile Thr Leu Tyr Cys Asn 
65                  70      


<210> 363
<211> 73
<212> PRT
<213> Homo sapiens

<400> 363
Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
1               5                   10                  15      


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            20                  25                  30          


Trp Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        35                  40                  45              


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    50                  55                  60                  


Tyr Cys Asn His Arg Asn Arg Arg Arg 
65                  70              


<210> 364
<211> 27
<212> PRT
<213> Homo sapiens

<400> 364
Ile Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu 
1               5                   10                  15      


Ile Val Gly Ala Val Phe Leu Cys Ala Arg Arg 
            20                  25          


<210> 365
<211> 52
<212> PRT
<213> Homo sapiens

<400> 365
Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
            20                  25                  30          


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
        35                  40                  45              


Pro Lys Asn Asn 
    50          


<210> 366
<211> 244
<212> PRT
<213> Homo sapiens

<400> 366
Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210> 367
<211> 86
<212> PRT
<213> Homo sapiens

<400> 367
Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210> 368
<211> 21
<212> PRT
<213> Homo sapiens

<400> 368
Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Gly Ala Phe Gly Phe 
            20      


<210> 369
<211> 20
<212> PRT
<213> Homo sapiens

<400> 369
Val Gly Trp Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val 
1               5                   10                  15      


Leu Ala Val Ile 
            20  


<210> 370
<211> 27
<212> PRT
<213> Homo sapiens

<400> 370
Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            20                  25          


<210> 371
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 371
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 372
<211> 474
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 372
atctctctga ttgcggcgct ggcagttgac tacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgttatcgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta cgaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgt            474


<210> 373
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 373
tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca       60

ggtggaggca gcttgcaa                                                     78


<210> 374
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 374
tccggtggag gtagcggtgg agggggttct ggtggaggag gttctggagg tggaggttct       60

ggcggtgggt ccttgcaa                                                     78


<210> 375
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 375
tctggcggag gaagcggagg cggaggatct ggtggtggtg gatctggcgg cggtggtagt       60

ggcggaggtt ctctgcaa                                                     78


<210> 376
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 376
tccggggggg gtagcggggg agggggttcc ggcgggggag ggtctggagg gggaggttcc       60

ggcggggggt ccttgcaa                                                     78


<210> 377
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 377
tctggcggag gatctggagg aggcggatct ggaggaggag gcagtggagg cggaggatct       60

ggcggaggat ctctgcag                                                     78


<210> 378
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 378
aattgggtca acgtgatcag cgacctgaag aagatcgagg acctgatcca gagcatgcac       60

atcgacgcca cactgtacac cgagtccgat gtgcacccta gctgcaaagt gaccgccatg      120

aagtgctttc tgctggaact gcaagtgatc agcctggaaa gcggcgacgc cagcatccac      180

gataccgtgg aaaatctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      240

accgagagcg gctgcaaaga gtgcgaggaa ctggaagaga agaacatcaa agagttcctc      300

cagagcttcg tccacatcgt gcagatgttc atcaacacca gc                         342


<210> 379
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 379
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat       60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg      120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat      180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta      240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg      300

cagagttttg tacatattgt ccaaatgttc atcaacactt ct                         342


<210> 380
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 380
atcacgtgcc ctccccccat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc       60

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      120

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      180

ctcaaatgca ttagagaccc tgccctggtt caccaaaggc cagcgccacc ctccacagta      240

acgacggcag gggtgacccc acagccagag agcctctccc cttctggaaa agagcccgca      300

gcttcatctc ccagctcaaa caacacagcg gccacaacag cagctattgt cccgggctcc      360

cagctgatgc cttcaaaatc accttccaca ggaaccacag agataagcag tcatgagtcc      420

tcccacggca ccccctctca gacaacagcc aagaactggg aactcacagc atccgcctcc      480

caccagccgc caggtgtgta tccacagggc cacagcgaca ccactgtggc tatctccacg      540

tccactgtcc tgctgtgtgg gctgagcgct gtgtctctcc tggcatgcta cctcaagtca      600

aggcaaactc ccccgctggc cagcgttgaa atggaagcca tggaggctct gccggtgact      660

tgggggacca gcagcagaga tgaagacttg gaaaactgct ctcaccacct a               711


<210> 381
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 381
atcacctgtc ctccacctat gagcgtggaa cacgccgaca tctgggtcaa gagctacagc       60

ctgtacagca gagagcggta catctgcaac agcggcttca agagaaaggc cggcacaagc      120

agcctgaccg agtgtgtgct gaacaaggcc acaaacgtgg cccactggac cacacctagc      180

ctgaagtgca tcagagatcc cgctctggtt caccagaggc ctgctcctcc atctacagtg      240

acaacagctg gcgtgacccc tcagcctgag tctctgtctc catctggaaa agagcctgcc      300

gccagctctc ccagctctaa caatactgct gccaccacag ccgccatcgt gcctggatct      360

cagctgatgc ctagcaagag ccctagcacc ggcacaacag agatcagctc tcacgagtct      420

agccacggca ccccatctca gaccacagcc aagaattggg agctgaccgc ctctgcctct      480

catcagccac ctggtgttta ccctcaaggc cactctgata ccaccgtggc catcagcaca      540

agcacagtgc tgctgtgtgg actgtctgcc gtgtctctgc tggcctgcta cctgaagtct      600

agacagacac ctcctctggc cagcgtggaa atggaagcca tggaagctct gcctgtgaca      660

tggggcacca gcagcagaga tgaggacctc gagaattgca gccaccacct g               711


<210> 382
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 382
attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc       60

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      120

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      180

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      240

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      300

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      360

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      420

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      480

caccagcctc caggagtgta tcctcagggc cactctgata caacagtggc catcagcaca      540

tctacagtgc tgctgtgtgg actgtctgcc gtgtctctgc tggcctgtta cctgaagtct      600

agacagacac ctcctctggc ctctgtggag atggaggcca tggaagccct gcctgtgaca      660

tggggaacaa gcagcagaga tgaggacctg gagaattgtt ctcaccacct g               711


<210> 383
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 383
Met Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210> 384
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 384
atgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210> 385
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 385
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
            20                  25                  30  


<210> 386
<211> 90
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      signal sequence

<400> 386
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc                                        90


<210> 387
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Flag sequence

<400> 387
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 388
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Flag sequence

<400> 388
gactacaaag acgatgacga caag                                              24


<210> 389
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 389
tcaggcgggg ggagt                                                        15


<210> 390
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 390
tctggtggcg ggagtggagg aggtgggtcc ggagggggag ggagcggtgg tggaggttcc       60

ggcggggggg gtagtggagg cggagggtca ggtgggggca gc                         102


<210> 391
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 391
agtggtggcg ggtccggcgg tggtggtagc gggggtggag gctcaggtgg cggtggcagt       60


<210> 392
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      spacer sequence

<400> 392
tctagataat acgactcact agagatcc                                          28


<210> 393
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      spacer sequence

<400> 393
tatggccaca accatg                                                       16


<210> 394
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      spacer sequence

<400> 394
aatctagata atacgactca ctagagatcc                                        30


<210> 395
<211> 474
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 395
atctctctga ttgcggcgct ggcagttgac cacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgtttacgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta caaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgt            474


<210> 396
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 396
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaat tcatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210> 397
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 397
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaat tcatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 398
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 398
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tcttcagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaagt tccgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210> 399
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 399
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tcttcagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaagt tccgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 400
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 400
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgagg agaatgat                                                    558


<210> 401
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 401
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

ggatacccag gtgttctctc tgatgtccag gaggagaaag gctttaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210> 402
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 402
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

ggatacccag gtgttctctc tgatgtccag gaggagaaag gctttaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210> 403
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 403
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccaggatacc caggtgttct ctctgatgtc caggaggaga aaggctttaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 404
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 404
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Glu Asn Asp 
            580             


<210> 405
<211> 1752
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 405
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

gagaatgatt ga                                                         1752


<210> 406
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 406
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgtatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 407
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 407
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210> 408
<211> 1752
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 408
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgtatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210> 409
<211> 404
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 409
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Tyr Pro 
145                 150                 155                 160 


Tyr Asp Val Pro Asp Tyr Ala Ile Thr Cys Pro Pro Pro Met Ser Val 
                165                 170                 175     


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
            180                 185                 190         


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
        195                 200                 205             


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
    210                 215                 220                 


Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg 
225                 230                 235                 240 


Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro 
                245                 250                 255     


Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser 
            260                 265                 270         


Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln 
        275                 280                 285             


Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser 
    290                 295                 300                 


His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp 
305                 310                 315                 320 


Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln 
                325                 330                 335     


Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu 
            340                 345                 350         


Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg 
        355                 360                 365             


Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu 
    370                 375                 380                 


Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys 
385                 390                 395                 400 


Ser His His Leu 
                


<210> 410
<211> 1215
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 410
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggtg gaggcagctt gcaataccca      480

tacgatgttc cagattacgc tattacctgc ccccctccga tgagcgtgga gcacgccgac      540

atctgggtca agagctacag cttgtatagt agggagcggt acatctgtaa cagcgggttc      600

aagaggaagg ccgggaccag ctcactgacc gagtgcgtgt tgaacaaggc caccaacgtg      660

gcccactgga ccacccctag ccttaagtgc atcagggacc cagcgctcgt acaccagaga      720

cccgcgcctc cctctacggt aaccacggca ggcgtaaccc cccagcccga gagcctgtcc      780

ccgagcggca aggagcctgc agcgagcagc ccctcaagca acaacacagc cgctaccacc      840

gcggcaatcg tgcccggcag ccagctgatg ccctcaaaga gccccagcac cggcaccact      900

gagataagca gccacgagag ctcacacggc actccctcac agaccactgc caagaattgg      960

gagctgaccg cctctgccag ccaccagccc ccaggcgtgt atccccaggg ccacagcgac     1020

accacggtcg ccatcagcac atctacagtg cttttgtgcg gccttagcgc cgtgtcactg     1080

ctggcatgct acttgaaaag taggcaaact ccccctcttg ccagtgtgga aatggaggcc     1140

atggaagccc tgcccgtgac ctggggcacc agttctaggg acgaggacct tgagaactgc     1200

tcacatcatt tgtga                                                      1215


<210> 411

<400> 411
000


<210> 412

<400> 412
000


<210> 413
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 413
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
                165                 170                 175     


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
            180                 185                 190         


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
        195                 200                 205             


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
    210                 215                 220                 


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
225                 230                 235                 240 


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
                245                 250                 255     


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
            260                 265                 270         


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
        275                 280                 285             


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
    290                 295                 300                 


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
305                 310                 315                 320 


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                325                 330                 335     


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
            340                 345                 350         


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
        355                 360                 365             


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
    370                 375                 380                 


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
385                 390                 395                 400 


His His Leu 
            


<210> 414
<211> 1212
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 414
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttctg gtggcgggag tggaggaggt      420

gggtccggag ggggagggag cggtggtgga ggttccggcg gggggggtag tggaggcgga      480

gggtcaggtg ggggcagcat tacctgcccc cctccgatga gcgtggagca cgccgacatc      540

tgggtcaaga gctacagctt gtatagtagg gagcggtaca tctgtaacag cgggttcaag      600

aggaaggccg ggaccagctc actgaccgag tgcgtgttga acaaggccac caacgtggcc      660

cactggacca cccctagcct taagtgcatc agggacccag cgctcgtaca ccagagaccc      720

gcgcctccct ctacggtaac cacggcaggc gtaacccccc agcccgagag cctgtccccg      780

agcggcaagg agcctgcagc gagcagcccc tcaagcaaca acacagccgc taccaccgcg      840

gcaatcgtgc ccggcagcca gctgatgccc tcaaagagcc ccagcaccgg caccactgag      900

ataagcagcc acgagagctc acacggcact ccctcacaga ccactgccaa gaattgggag      960

ctgaccgcct ctgccagcca ccagccccca ggcgtgtatc cccagggcca cagcgacacc     1020

acggtcgcca tcagcacatc tacagtgctt ttgtgcggcc ttagcgccgt gtcactgctg     1080

gcatgctact tgaaaagtag gcaaactccc cctcttgcca gtgtggaaat ggaggccatg     1140

gaagccctgc ccgtgacctg gggcaccagt tctagggacg aggaccttga gaactgctca     1200

catcatttgt ga                                                         1212


<210> 415
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 415
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
145                 150                 155                 160 


Ala Ser Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
                165                 170                 175     


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
            180                 185                 190         


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
        195                 200                 205             


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
    210                 215                 220                 


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
225                 230                 235                 240 


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
                245                 250                 255     


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
            260                 265                 270         


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
        275                 280                 285             


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
    290                 295                 300                 


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
305                 310                 315                 320 


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                325                 330                 335     


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
            340                 345                 350         


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
        355                 360                 365             


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
    370                 375                 380                 


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
385                 390                 395                 400 


His His Leu 
            


<210> 416
<211> 1212
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 416
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctagtg gtggcgggtc cggcggtggt      420

ggtagcgggg gtggaggctc aggtggcggt ggcagttatc cttacgatgt gcccgactat      480

gcttcaggcg gggggagtat tacctgcccc cctccgatga gcgtggagca cgccgacatc      540

tgggtcaaga gctacagctt gtatagtagg gagcggtaca tctgtaacag cgggttcaag      600

aggaaggccg ggaccagctc actgaccgag tgcgtgttga acaaggccac caacgtggcc      660

cactggacca cccctagcct taagtgcatc agggacccag cgctcgtaca ccagagaccc      720

gcgcctccct ctacggtaac cacggcaggc gtaacccccc agcccgagag cctgtccccg      780

agcggcaagg agcctgcagc gagcagcccc tcaagcaaca acacagccgc taccaccgcg      840

gcaatcgtgc ccggcagcca gctgatgccc tcaaagagcc ccagcaccgg caccactgag      900

ataagcagcc acgagagctc acacggcact ccctcacaga ccactgccaa gaattgggag      960

ctgaccgcct ctgccagcca ccagccccca ggcgtgtatc cccagggcca cagcgacacc     1020

acggtcgcca tcagcacatc tacagtgctt ttgtgcggcc ttagcgccgt gtcactgctg     1080

gcatgctact tgaaaagtag gcaaactccc cctcttgcca gtgtggaaat ggaggccatg     1140

gaagccctgc ccgtgacctg gggcaccagt tctagggacg aggaccttga gaactgctca     1200

catcatttgt ga                                                         1212


<210> 417
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 417
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
    130                 135                 140                 


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
145                 150                 155                 160 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                165                 170                 175     


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
            180                 185                 190         


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
        195                 200                 205             


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
    210                 215                 220                 


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
                245                 250                 255     


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
            260                 265                 270         


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
        275                 280                 285             


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
    290                 295                 300                 


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
305                 310                 315                 320 


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
                325                 330                 335     


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
            340                 345                 350         


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
        355                 360                 365             


His His Leu 
    370     


<210> 418
<211> 1116
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 418
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctagtg gtattacctg cccccctccg      420

atgagcgtgg agcacgccga catctgggtc aagagctaca gcttgtatag tagggagcgg      480

tacatctgta acagcgggtt caagaggaag gccgggacca gctcactgac cgagtgcgtg      540

ttgaacaagg ccaccaacgt ggcccactgg accaccccta gccttaagtg catcagggac      600

ccagcgctcg tacaccagag acccgcgcct ccctctacgg taaccacggc aggcgtaacc      660

ccccagcccg agagcctgtc cccgagcggc aaggagcctg cagcgagcag cccctcaagc      720

aacaacacag ccgctaccac cgcggcaatc gtgcccggca gccagctgat gccctcaaag      780

agccccagca ccggcaccac tgagataagc agccacgaga gctcacacgg cactccctca      840

cagaccactg ccaagaattg ggagctgacc gcctctgcca gccaccagcc cccaggcgtg      900

tatccccagg gccacagcga caccacggtc gccatcagca catctacagt gcttttgtgc      960

ggccttagcg ccgtgtcact gctggcatgc tacttgaaaa gtaggcaaac tccccctctt     1020

gccagtgtgg aaatggaggc catggaagcc ctgcccgtga cctggggcac cagttctagg     1080

gacgaggacc ttgagaactg ctcacatcat ttgtga                               1116


<210> 419
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 419
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asn Trp 
            20                  25                  30          


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        35                  40                  45              


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    50                  55                  60                  


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
65                  70                  75                  80  


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                85                  90                  95      


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            100                 105                 110         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        115                 120                 125             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
225                 230                 235                 240 


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
                245                 250                 255     


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
            260                 265                 270         


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
        275                 280                 285             


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
    290                 295                 300                 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
305                 310                 315                 320 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
                325                 330                 335     


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
            340                 345                 350         


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
        355                 360                 365             


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
    370                 375                 380                 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Asn Cys Ser His His Leu 
                405         


<210> 420
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 420
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggtgg aggtagcggt ggagggggtt ctggtggagg aggttctgga      480

ggtggaggtt ctggcggtgg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210> 421
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 421
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser 
385                 390                 395         


<210> 422
<211> 1194
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 422
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgggatc ctga           1194


<210> 423

<400> 423
000


<210> 424
<211> 555
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 424
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210> 425
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 425
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgagcgg catctctctg     1200

attgcggcgc tggcagttga ctacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgttatcga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acgaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttag                  1668


<210> 426
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 426
Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asn Trp 
            20                  25                  30          


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        35                  40                  45              


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    50                  55                  60                  


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
65                  70                  75                  80  


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                85                  90                  95      


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            100                 105                 110         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        115                 120                 125             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
225                 230                 235                 240 


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
                245                 250                 255     


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
            260                 265                 270         


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
        275                 280                 285             


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
    290                 295                 300                 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
305                 310                 315                 320 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
                325                 330                 335     


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
            340                 345                 350         


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
        355                 360                 365             


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
    370                 375                 380                 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Asn Cys Ser His His Leu 
                405         


<210> 427
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 427
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggtgg aggtagcggt ggagggggtt ctggtggagg aggttctgga      480

ggtggaggtt ctggcggtgg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210> 428
<211> 371
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 428
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
    130                 135                 140                 


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
145                 150                 155                 160 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                165                 170                 175     


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
            180                 185                 190         


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
        195                 200                 205             


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
    210                 215                 220                 


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
                245                 250                 255     


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
            260                 265                 270         


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
        275                 280                 285             


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
    290                 295                 300                 


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
305                 310                 315                 320 


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
                325                 330                 335     


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
            340                 345                 350         


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
        355                 360                 365             


His His Leu 
    370     


<210> 429
<211> 1116
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 429
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctggat ccattacctg cccccctccg      420

atgagcgtgg agcacgccga catctgggtc aagagctaca gcttgtatag tagggagcgg      480

tacatctgta acagcgggtt caagaggaag gccgggacca gctcactgac cgagtgcgtg      540

ttgaacaagg ccaccaacgt ggcccactgg accaccccta gccttaagtg catcagggac      600

ccagcgctcg tacaccagag acccgcgcct ccctctacgg taaccacggc aggcgtaacc      660

ccccagcccg agagcctgtc cccgagcggc aaggagcctg cagcgagcag cccctcaagc      720

aacaacacag ccgctaccac cgcggcaatc gtgcccggca gccagctgat gccctcaaag      780

agccccagca ccggcaccac tgagataagc agccacgaga gctcacacgg cactccctca      840

cagaccactg ccaagaattg ggagctgacc gcctctgcca gccaccagcc cccaggcgtg      900

tatccccagg gccacagcga caccacggtc gccatcagca catctacagt gcttttgtgc      960

ggccttagcg ccgtgtcact gctggcatgc tacttgaaaa gtaggcaaac tccccctctt     1020

gccagtgtgg aaatggaggc catggaagcc ctgcccgtga cctggggcac cagttctagg     1080

gacgaggacc ttgagaactg ctcacatcat ttgtga                               1116


<210> 430
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 430
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggggg gggtagcggg ggagggggtt ccggcggggg agggtctgga      480

gggggaggtt ccggcggggg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210> 431
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 431
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgtag                  1188


<210> 432
<211> 573
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 432
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Ile 
                405                 410                 415     


Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn 
            420                 425                 430         


Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn 
        435                 440                 445             


Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile 
    450                 455                 460                 


Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro 
465                 470                 475                 480 


Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile 
                485                 490                 495     


Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg 
            500                 505                 510         


Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His 
        515                 520                 525             


Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro 
    530                 535                 540                 


Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln 
545                 550                 555                 560 


Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
                565                 570             


<210> 433
<211> 1722
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 433
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggaatctc tctgattgcg     1260

gcgctggcag ttgactacgt tattggcatg gaaaacgcga tgccatggaa cctcccggct     1320

gacctggcgt ggttcaaacg taacaccctg aacaaacctg tgatcatggg tcgtcacacc     1380

tgggaatcta ttggccgtcc tctcccgggt cgtaaaaaca tcattctgtc ttctcagcca     1440

ggcaccgacg accgtgttac ctgggttaaa agcgttgacg aagcgattgc tgcgtgcggt     1500

gatgttcctg aaattatggt gatcggcggt ggccgtgtta tcgaacagtt cctgccgaaa     1560

gcgcagaaac tgtacctgac ccacatcgac gcggaagttg aaggtgacac ccacttcccg     1620

gactacgaac cggatgattg ggagagcgta ttctccgaat tccatgatgc ggatgcgcaa     1680

aactctcatt cttactgttt tgaaatcctg gaacgtcgtt ga                        1722


<210> 434
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 434
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser 
                405                 410                 


<210> 435
<211> 1245
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 435
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat cctga                     1245


<210> 436
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 436
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Glu Asn Asp 
        595                 600     


<210> 437
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 437
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgaggagaat     1800

gattga                                                                1806


<210> 438
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 438
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Gly 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210> 439
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 439
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccaggata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcttt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210> 440
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 440
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210> 441
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 441
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gcagacttaa actatttgtg acaaggatca tgcaagactt tggaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210> 442
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 442
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgtcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 443
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 443
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210> 444
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 444
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210> 445
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 445
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210> 446
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 446
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

tatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210> 447
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 447
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgtcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 448
<211> 601
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 448
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210> 449
<211> 1806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 449
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210> 450
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 450
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggcaga cttaaactat ttgtgacaag gatcatgcaa      420

gactttggaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210> 451
<211> 2291
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 451
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

tgatctagat aatacgactc actagagatc ccgcccctct ccctcccccc cccctaacgt     1020

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     1080

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     1140

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     1200

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     1260

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     1320

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     1380

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     1440

ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag     1500

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     1560

atgataatat ggccacaacc atgatgagca agggcgagga ggataacatg gccatcatca     1620

aggagttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac gagttcgaga     1680

tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag ctgaaggtga     1740

ccaagggtgg ccccctgccc ttcgcctggg acatcctgtc ccctcagttc atgtacggct     1800

ccaaggccta cgtgaagcac cccgccgaca tccccgacta cttgaagctg tccttccccg     1860

agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc     1920

aggactcctc cctgcaggac ggcgagttca tctacaaggt gaagctgcgc ggcaccaact     1980

tcccctccga cggccccgta atgcagaaga agaccatggg ctgggaggcc tcctccgagc     2040

ggatgtaccc cgaggacggc gccctgaagg gcgagatcaa gcagaggctg aagctgaagg     2100

acggcggcca ctacgacgct gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc     2160

tgcccggcgc ctacaacgtc aacatcaagt tggacatcac ctcccacaac gaggactaca     2220

ccatcgtgga acagtacgaa cgcgccgagg gccgccactc caccggcggc atggacgagc     2280

tgtacaagta a                                                          2291


<210> 452
<211> 320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 452
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Val Gly Ser Leu Asn Cys Ile Val Ala Val 
    130                 135                 140                 


Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro 
145                 150                 155                 160 


Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser 
                165                 170                 175     


Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe 
            180                 185                 190         


Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val 
        195                 200                 205             


Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser 
    210                 215                 220                 


Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala 
225                 230                 235                 240 


Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys 
                245                 250                 255     


Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile 
            260                 265                 270         


Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu 
        275                 280                 285             


Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln 
    290                 295                 300                 


Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
305                 310                 315                 320 


<210> 453
<211> 963
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 453
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

tga                                                                    963


<210> 454
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 454
Met Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210> 455
<211> 708
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 455
atgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210> 456
<211> 1735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 456
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat cctgaaatct agataatacg      420

actcactaga gatcccgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc      480

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt      540

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt      600

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg      660

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca      720

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg      780

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc      840

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct      900

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta      960

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac     1020

aaccatgatg agcaagggcg aggaggataa catggccatc atcaaggagt tcatgcgctt     1080

caaggtgcac atggagggct ccgtgaacgg ccacgagttc gagatcgagg gcgagggcga     1140

gggccgcccc tacgagggca cccagaccgc caagctgaag gtgaccaagg gtggccccct     1200

gcccttcgcc tgggacatcc tgtcccctca gttcatgtac ggctccaagg cctacgtgaa     1260

gcaccccgcc gacatccccg actacttgaa gctgtccttc cccgagggct tcaagtggga     1320

gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg acccaggact cctccctgca     1380

ggacggcgag ttcatctaca aggtgaagct gcgcggcacc aacttcccct ccgacggccc     1440

cgtaatgcag aagaagacca tgggctggga ggcctcctcc gagcggatgt accccgagga     1500

cggcgccctg aagggcgaga tcaagcagag gctgaagctg aaggacggcg gccactacga     1560

cgctgaggtc aagaccacct acaaggccaa gaagcccgtg cagctgcccg gcgcctacaa     1620

cgtcaacatc aagttggaca tcacctccca caacgaggac tacaccatcg tggaacagta     1680

cgaacgcgcc gagggccgcc actccaccgg cggcatggac gagctgtaca agtaa          1735


<210> 457
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 457
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser 
    130                 


<210> 458
<211> 405
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 458
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat cctga                      405


<210> 459
<211> 681
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 459
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Arg Met Asp Tyr 
385                 390                 395                 400 


Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr 
                405                 410                 415     


Lys Asp Asp Asp Asp Lys Ser Arg Gly Ser Gly Ala Thr Asn Phe Ser 
            420                 425                 430         


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Leu Ser 
        435                 440                 445             


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
    450                 455                 460                 


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
465                 470                 475                 480 


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
                485                 490                 495     


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
            500                 505                 510         


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
        515                 520                 525             


Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
    530                 535                 540                 


Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp 
545                 550                 555                 560 


Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly 
                565                 570                 575     


Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
            580                 585                 590         


Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys 
        595                 600                 605             


Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp 
    610                 615                 620                 


Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro 
625                 630                 635                 640 


Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu 
                645                 650                 655     


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser 
            660                 665                 670         


Thr Gly Gly Met Asp Glu Leu Tyr Lys 
        675                 680     


<210> 460
<211> 2046
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 460
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaactgg       60

gtgaatgtga tcagcgacct gaagaagatc gaggatctga tccagagcat gcacattgat      120

gccaccctgt acacagaatc tgatgtgcac cctagctgta aagtgaccgc catgaagtgt      180

tttctgctgg agctgcaggt gatttctctg gaaagcggag atgcctctat ccacgacaca      240

gtggagaatc tgatcatcct ggccaacaat agcctgagca gcaatggcaa tgtgacagag      300

tctggctgta aggagtgtga ggagctggag gagaagaaca tcaaggagtt tctgcagagc      360

tttgtgcaca tcgtgcagat gttcatcaat acaagctctg gcggaggatc tggaggaggc      420

ggatctggag gaggaggcag tggaggcgga ggatctggcg gaggatctct gcagattaca      480

tgccctcctc caatgtctgt ggagcacgcc gatatttggg tgaagtccta cagcctgtac      540

agcagagaga gatacatctg caacagcggc tttaagagaa aggccggcac ctcttctctg      600

acagagtgcg tgctgaataa ggccacaaat gtggcccact ggacaacacc tagcctgaag      660

tgcattagag atcctgccct ggtccaccag aggcctgccc ctccatctac agtgacaaca      720

gccggagtga cacctcagcc tgaatctctg agcccttctg gaaaagaacc tgccgccagc      780

tctcctagct ctaataatac cgccgccaca acagccgcca ttgtgcctgg atctcagctg      840

atgcctagca agtctcctag cacaggcaca acagagatca gcagccacga atcttctcac      900

ggaacacctt ctcagaccac cgccaagaat tgggagctga cagcctctgc ctctcaccag      960

cctccaggag tgtatcctca gggccactct gatacaacag tggccatcag cacatctaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gttacctgaa gtctagacag     1080

acacctcctc tggcctctgt ggagatggag gccatggaag ccctgcctgt gacatgggga     1140

acaagcagca gagatgagga cctggagaat tgttctcacc acctgtcgcg aatggactac     1200

aaggacgatg acgacaagga ttataaagat gatgatgata aagattataa agacgacgat     1260

gataagtcgc gaggatccgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     1320

gaggagaacc ctggaccttt gagcaagggc gaggaggaca acatggccat catcaaggag     1380

ttcatgcgct tcaaggtgca catggagggc tccgtgaacg gccacgagtt cgagatcgag     1440

ggcgagggcg agggccgccc ctacgagggc acccagaccg ccaagctgaa ggtgaccaag     1500

ggcggccccc tgcccttcgc ctgggacatc ctgtcccctc agttcatgta cggctccaag     1560

gcctacgtga agcaccccgc cgacatcccc gactacttga agctgtcctt ccccgagggc     1620

ttcaagtggg agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt gacccaggac     1680

tcctccctgc aggacggcga gttcatctac aaggtgaagc tgcgcggcac caacttcccc     1740

tccgacggcc ccgtaatgca gaagaagacc atgggctggg aggcctcctc cgagcggatg     1800

taccccgagg acggcgccct gaagggcgag atcaagcaga ggctgaagct gaaggacggc     1860

ggccactacg acgccgaggt caagaccacc tacaaggcca agaagcccgt gcagctgccc     1920

ggcgcctaca acgtcaacat caagctggac atcacctccc acaacgagga ctacaccatc     1980

gtggaacagt acgagcgcgc cgagggccgc cactccaccg gcggcatgga cgagctgtac     2040

aagtaa                                                                2046


<210> 461
<211> 652
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 461
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Ala Thr 
385                 390                 395                 400 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                405                 410                 415     


Pro Leu Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
            420                 425                 430         


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
        435                 440                 445             


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
    450                 455                 460                 


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
465                 470                 475                 480 


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
                485                 490                 495     


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
            500                 505                 510         


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
        515                 520                 525             


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
    530                 535                 540                 


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
545                 550                 555                 560 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
                565                 570                 575     


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
            580                 585                 590         


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
        595                 600                 605             


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
    610                 615                 620                 


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
625                 630                 635                 640 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                645                 650         


<210> 462
<211> 1959
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 462
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaactgg       60

gtgaatgtga tcagcgacct gaagaagatc gaggatctga tccagagcat gcacattgat      120

gccaccctgt acacagaatc tgatgtgcac cctagctgta aagtgaccgc catgaagtgt      180

tttctgctgg agctgcaggt gatttctctg gaaagcggag atgcctctat ccacgacaca      240

gtggagaatc tgatcatcct ggccaacaat agcctgagca gcaatggcaa tgtgacagag      300

tctggctgta aggagtgtga ggagctggag gagaagaaca tcaaggagtt tctgcagagc      360

tttgtgcaca tcgtgcagat gttcatcaat acaagctctg gcggaggatc tggaggaggc      420

ggatctggag gaggaggcag tggaggcgga ggatctggcg gaggatctct gcagattaca      480

tgccctcctc caatgtctgt ggagcacgcc gatatttggg tgaagtccta cagcctgtac      540

agcagagaga gatacatctg caacagcggc tttaagagaa aggccggcac ctcttctctg      600

acagagtgcg tgctgaataa ggccacaaat gtggcccact ggacaacacc tagcctgaag      660

tgcattagag atcctgccct ggtccaccag aggcctgccc ctccatctac agtgacaaca      720

gccggagtga cacctcagcc tgaatctctg agcccttctg gaaaagaacc tgccgccagc      780

tctcctagct ctaataatac cgccgccaca acagccgcca ttgtgcctgg atctcagctg      840

atgcctagca agtctcctag cacaggcaca acagagatca gcagccacga atcttctcac      900

ggaacacctt ctcagaccac cgccaagaat tgggagctga cagcctctgc ctctcaccag      960

cctccaggag tgtatcctca gggccactct gatacaacag tggccatcag cacatctaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gttacctgaa gtctagacag     1080

acacctcctc tggcctctgt ggagatggag gccatggaag ccctgcctgt gacatgggga     1140

acaagcagca gagatgagga cctggagaat tgttctcacc acctgggatc cggagctact     1200

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tttgagcaag     1260

ggcgaggagg acaacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag     1320

ggctccgtga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     1380

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac     1440

atcctgtccc ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc     1500

cccgactact tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     1560

gaggacggcg gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc     1620

tacaaggtga agctgcgcgg caccaacttc ccctccgacg gccccgtaat gcagaagaag     1680

accatgggct gggaggcctc ctccgagcgg atgtaccccg aggacggcgc cctgaagggc     1740

gagatcaagc agaggctgaa gctgaaggac ggcggccact acgacgccga ggtcaagacc     1800

acctacaagg ccaagaagcc cgtgcagctg cccggcgcct acaacgtcaa catcaagctg     1860

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg cgccgagggc     1920

cgccactcca ccggcggcat ggacgagctg tacaagtaa                            1959


<210> 463

<400> 463
000

<210> 464

<400> 464
000


<210> 465
<211> 525
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 465
attacctgcc cccctccgat gagcgtggag cacgccgaca tctgggtcaa gagctacagc       60

ttgtatagta gggagcggta catctgtaac agcgggttca agaggaaggc cgggaccagc      120

tcactgaccg agtgcgtgtt gaacaaggcc accaacgtgg cccactggac cacccctagc      180

cttaagtgca tcagggaccc agcgctcgta caccagagac ccgcgcctcc ctctacggta      240

accacggcag gcgtaacccc ccagcccgag agcctgtccc cgagcggcaa ggagcctgca      300

gcgagcagcc cctcaagcaa caacacagcc gctaccaccg cggcaatcgt gcccggcagc      360

cagctgatgc cctcaaagag ccccagcacc ggcaccactg agataagcag ccacgagagc      420

tcacacggca ctccctcaca gaccactgcc aagaattggg agctgaccgc ctctgccagc      480

caccagcccc caggcgtgta tccccagggc cacagcgaca ccacg                      525


<210> 466
<211> 207
<212> DNA
<213> Homo sapiens

<400> 466
accacaaccc cagcacctcg cccaccaaca ccagcaccaa ccatcgcatc ccagccactg       60

tctctgaggc ccgaggcatg taggcctgca gcaggaggcg ccgtgcacac caggggcctg      120

gactttgcct gcgatatcta tatctgggca ccactggcag gaacatgtgg cgtgctgctg      180

ctgtccctgg tcatcaccct gtattgc                                          207


<210> 467

<400> 467
000
        


<210> 468

<400> 468
000


<210> 469
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 469
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcgt cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 470
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 470
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaaccgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 471
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 471
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga aggatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 472
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 472
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

agggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 473
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 473
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccaggagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagt aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 474
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 474
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgta tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tagagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 475
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 475
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcata      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 476
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 476
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg aggagaatga t                                                561


<210> 477
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 477
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtaattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaggtatatg agaaggatga t                                                561


<210> 478
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 478
atggttggtt cgctaaaccg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatgcc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 479
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 479
atggttggtt cgctaaactg catcgttgtt gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ttattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 480
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 480
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcgg tagaaggtaa acagaatctg gtgattatgg gtaagaaggc ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agagctaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 481
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 481
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag gatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttcttag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtt tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc cgtcttaaac tatttgtgac aaggatcatg      420

caagactttg gaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 482
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 482
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat acttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgag aaggatcatg      420

caagaccttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 483
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 483
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gcacaaattt      540

ggagtatatg agaagaatga t                                                561


<210> 484
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 484
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggagcctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagacttcg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtacatg aggagaatga t                                                561


<210> 485
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 485
atggttggtt cgctaaactg catcgccgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaaggc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcta gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 486
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 486
atggttggtt cgctaaactg cgtcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttgaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatgcc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 487
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 487
atggttggct cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggactcgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gcttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaatg taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 488
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 488
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcgagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcatcttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtctataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

ggagtatatg agaagaatga t                                                561


<210> 489
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 489
atggttggtt cgctgaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcctcag tagaaggtaa gcagaatctg gtgattatgc gtaagaagac ctggttctcc      180

attcctgaga agaatagacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ccattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggttagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcgtg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctgtgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaggtatatg agaagaatga t                                                561


<210> 490
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 490
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat acttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagtcctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagca gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttatgac gaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgacc tggagaaata taaactcctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattag gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 491
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 491
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acaggatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tgtttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattggtt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 492
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 492
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

gaggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agagttaatt tagttcttag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttcc      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggcgttct ctctgatgtc caggaggaga aaggcactaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 493
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 493
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ccattttctc tccagaagtc tggatgatgc cctaaaacct      300

actggacgat caggattagc agataaagta gacatggccc ggatagttgg cggcagctct      360

gtttgtaagg aagccataag gtacccaggc caccctaagc tacctgtgac aaggaccatg      420

caagactttg aaagtgacac gtctcttcca gaagttgcct tggagaagta taagcttctg      480

ccagaatacc caggtgtgct ctctggtgcc caggaggaga agggcgctag gtacaagttt      540

gaagcatacg aaaggagtga t                                                561


<210> 494
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 494
atggctggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcggat atttccggag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaacct      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga agggcattaa gtacaaattt      540

gaagtatatg agaggaatga t                                                561


<210> 495
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 495
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgagcgt cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat attttcagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcatcttctt tccagaagtc tagatggtgc cttaaaactt      300

actgagcaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttatgagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcgtg      420

caagactttg agagtggcac gtttttccca gaaattgatt tggagagata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 496
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 496
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atctccaggg aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga aggctcgacc ttcagagggt ggaattaatt tagttctcag tagagaaccc      240

aaggaacctc cacaaggagc tcatttcctt tccagaagtc tagatgatgc cttaggactt      300

actgaacaac cggaattagc aaataaagta gacatggtct ggatagttga tggcagctct      360

gtttataagg aagccatgaa tcacccaggc caccctaaac tatttgtgac aagggtcata      420

caaggctttg aaagtggcac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgacgtc caggagggga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatgg t                                                561


<210> 497
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 497
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcaa cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tggatgatgc ctcaagactt      300

actgaacaac cagaattagc caataaagta gacacagtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca ggaattgatt tggagaaata taaacttctg      480

ccaggatacc caggtgttct ctctgatgtc cagggggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210> 498
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 498
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac agggatcatg      420

caaggctctg aaagtgacac gttttttcca gaaattgatt tggagagata tgaacttctg      480

ccaggatacc caggtgctct ctctgatgtt caggaggaga aaggcattga gtgcaaattt      540

gaagtatatg aggagagtga c                                                561


<210> 499
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 499
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagagctc      240

agggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaagacct      300

actggacaac cagaattagc agataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataggg aagccatgaa tcgcccaggc catcttaaac tgtttgtaac aaggatcatg      420

caaggctttg aaagtgacac gttttttcca gaaattgatt tggagaaata taagcttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaactt      540

gaagtgtatg aggagaatga t                                                561


<210> 500
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 500
atggttggtt cgctaaactg catcgtcgct gtgtcccaga gcatgggcat cggcaagaac       60

ggggacctgt cctggccacc gctcaggaat gaattcagat atctccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattacgg gtaaggagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaatcaatt tagtcctcag cagagagctc      240

aaggaacctc cacaaggagc tcattttctt tccgggggtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgag ttacccaggc catcttaaac tacttgtgac aaggatcatg      420

caagactctg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacctccg      480

ccagaatacc caggtgttct ctctgatgtc caggaggcga aaggcattaa gtacaaactt      540

gaagtatatg agaagaatga t                                                561


<210> 501
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 501
atggctggtt cgctaaactg catcgtcgct gtgtcccaga atatgggcgt cggcaagaac       60

ggggacctgc cctggccacc gctcagggat ggattcagat atttccggag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaatcgacc tttagagggt agaactaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ttatcttctt tccagaagtc tagatgatgc cttaaaactt      300

actgagcagc cagaattagc agatgaagca ggcatggtct gggtagttgg tggcagttct      360

gttgataagg aagccatgaa tcacccaggc catcccaaac tatctgtgac aaggatcgtg      420

caagactttg gaagtgacgc gttttttcca gaaattgatt tggagaaatg caaacttctg      480

ccagaatacc caggtgttct ctctgatgcc caggaggaga gaggcattaa gtacaaattt      540

gaagtatacg agaagagtga c                                                561


<210> 502
<211> 561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 502
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gcccaggcat gaattcagat atttccagag agtgaccaca      120

acctcttcag cagaaggtaa acagaatctg gtgattatgg gcaagaagac ctggttctcc      180

atccctgaga agaatcgacc ttcaaagggt agaattggtt tagttctcag cggagaactc      240

aaggaacctc cacagggagc ccactttctc tccaggagtc tagatgatac cttaagactt      300

actgaacaac cagaattaac gaatagagta aacatggtct ggatagttgg tggcagttct      360

gtttataagg aggccatgaa tcacccaggc caccttagac cagttgtgac aaggatcatg      420

caggactttg aaagcgacgc gttttttcca gaagttgact tggagaaata tagacttcta      480

ccagaatacc caggtgttct ctctgatgtc cagggggaga aaggcattaa gtacaaattt      540

gaagcatata ggaagaatga t                                                561


<210> 503
<211> 558
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Destabilizing Domain (DD)

<400> 503
atggttggct cgctaaactg catcgtcact gtgtcccgga gcatgggcat cggcaaggac       60

ggggacctgt cctggccacc gctcaggagt gaattcaggt actttcagag aacgaccgca      120

acctcttcag tagaaggtag acagagtctg gtgatcatgg gcaagaggac ctggttctcc      180

actcctgaga ggaatcgacc cttaaggggt agagctaact tagttctcag cggagagctc      240

aagggacctc cacaaggagc tcatcttctt tccagaagtc tagatggtgc cttaaaactt      300

actgaacagc cagagttagc agataaagta gacgtggtcc ggatagttgg tggcagttct      360

gttgatgagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aagagtcatg      420

cggggctttg aaagtgatac gctttttcca ggaatcgact tggggaaacg taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc cgggaggaga aaggcattaa gtacaaactt      540

gaagtatgtg ggaataat                                                    558


<210> 504
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 504
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Gly Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210> 505
<211> 1752
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 505
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc aggataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggctttaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210> 506
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 506
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Gly Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 507
<211> 320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 507
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Val Gly Ser Leu Asn Cys Ile Val Ala Val 
    130                 135                 140                 


Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro 
145                 150                 155                 160 


Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser 
                165                 170                 175     


Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe 
            180                 185                 190         


Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val 
        195                 200                 205             


Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser 
    210                 215                 220                 


Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala 
225                 230                 235                 240 


Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys 
                245                 250                 255     


Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile 
            260                 265                 270         


Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu 
        275                 280                 285             


Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln 
    290                 295                 300                 


Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
305                 310                 315                 320 


<210> 508
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 508
Tyr Asp Ser Leu Glu Ile Pro Pro Leu Ser Leu Pro Pro Pro 
1               5                   10                  


<210> 509
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 509
Arg Tyr Trp Pro Lys Pro Leu Gly Ile Arg Pro Val Cys Val Cys Leu 
1               5                   10                  15      


Tyr Val Ile Phe His His Ile Ala Val Phe Trp Gln Cys Glu Gly Pro 
            20                  25                  30          


Glu Thr Trp Pro Cys Leu Leu Asp Glu His Ser 
        35                  40              


<210> 510
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 510
Gly Ser Phe Pro Ser Arg Gln Arg Asn Ala Arg Ser Val Glu Cys Arg 
1               5                   10                  15      


Glu Gly Ser Ser Ser Ser Gly Ser Phe Leu Lys Thr Asn Asn Val Cys 
            20                  25                  30          


Ser Asp Pro Leu Gln Ala Ala Glu Pro Pro Thr Trp Arg Gln Val Pro 
        35                  40                  45              


Leu Arg Pro Lys Ala Thr Cys Ile Arg Tyr Thr Cys Lys Gly Gly Thr 
    50                  55                  60                  


Thr Pro Val Pro Arg Cys Glu Leu Asp Ser Cys Gly Lys Ser Gln Met 
65                  70                  75                  80  


Ala Leu Leu Lys Arg Ile Gln Gln Gly Ala Glu Gly Cys Pro Glu Gly 
                85                  90                  95      


Thr Pro Leu Tyr Gly Ile 
            100         


<210> 511
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 511
Ser Gly Ala Ser Val His Met Leu Tyr Met Cys Leu Val Glu Val Lys 
1               5                   10                  15      


Lys Thr Ser Arg Pro Pro Glu Pro Arg Gly Arg Gly Phe Pro Leu Lys 
            20                  25                  30          


Asn Thr Met Ile Ile Trp Pro Gln Pro 
        35                  40      


<210> 512
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 512
Ala Arg Ala Arg Arg Ile Thr Trp Pro Ser Ser Arg Ser Ser Cys Ala 
1               5                   10                  15      


Ser Arg Cys Thr Trp Arg Ala Pro 
            20                  


<210> 513
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 513
Thr Ala Thr Ser Ser Arg Ser Arg Ala Arg Ala Arg Ala Ala Pro Thr 
1               5                   10                  15      


Arg Ala Pro Arg Pro Pro Ser 
            20              


<210> 514
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 514
Pro Arg Val Ala Pro Cys Pro Ser Pro Gly Thr Ser Cys Pro Leu Ser 
1               5                   10                  15      


Ser Cys Thr Ala Pro Arg Pro Thr 
            20                  


<210> 515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 515
Ser Thr Pro Pro Thr Ser Pro Thr Thr 
1               5                   


<210> 516
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 516
Ser Cys Pro Ser Pro Arg Ala Ser Ser Gly Ser Ala 
1               5                   10          


<210> 517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 517
Thr Ser Arg Thr Ala Ala Trp 
1               5           


<210> 518
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 518
Pro Arg Thr Pro Pro Cys Arg Thr Ala Ser Ser Ser Thr Arg 
1               5                   10                  


<210> 519
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 519
Ser Cys Ala Ala Pro Thr Ser Pro Pro Thr Ala Pro 
1               5                   10          


<210> 520
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 520
Cys Arg Arg Arg Pro Trp Ala Gly Arg Pro Pro Pro Ser Gly Cys Thr 
1               5                   10                  15      


Pro Arg Thr Ala Pro 
            20      


<210> 521
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 521
Arg Ala Arg Ser Ser Arg Gly 
1               5           


<210> 522
<211> 64
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 522
Arg Thr Ala Ala Thr Thr Thr Leu Arg Ser Arg Pro Pro Thr Arg Pro 
1               5                   10                  15      


Arg Ser Pro Cys Ser Cys Pro Ala Pro Thr Thr Ser Thr Ser Ser Trp 
            20                  25                  30          


Thr Ser Pro Pro Thr Thr Arg Thr Thr Pro Ser Trp Asn Ser Thr Asn 
        35                  40                  45              


Ala Pro Arg Ala Ala Thr Pro Pro Ala Ala Trp Thr Ser Cys Thr Ser 
    50                  55                  60                  


<210> 523
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 523
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser 
    130                 


<210> 524
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 524
Asn Leu Asp Asn Thr Thr His 
1               5           


<210> 525
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 525
Arg Ser Arg Pro Ser Pro Ser Pro Pro Pro Asn Val Thr Gly Arg Ser 
1               5                   10                  15      


Arg Leu Glu 
            


<210> 526
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 526
Gly Arg Cys Ala Phe Val Tyr Met Leu Phe Ser Thr Ile Leu Pro Ser 
1               5                   10                  15      


Phe Gly Asn Val Arg Ala Arg Lys Pro Gly Pro Val Phe Leu Thr Ser 
            20                  25                  30          


Ile Pro Arg Gly Leu Ser Pro Leu Ala Lys Gly Met Gln Gly Leu Leu 
        35                  40                  45              


Asn Val Val Lys Glu Ala Val Pro Leu Glu Ala Ser 
    50                  55                  60  


<210> 527
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 527
Arg Gln Thr Thr Ser Val Ala Thr Leu Cys Arg Gln Arg Asn Pro Pro 
1               5                   10                  15      


Pro Gly Asp Arg Cys Leu Cys Gly Gln Lys Pro Arg Val 
            20                  25                  


<210> 528
<211> 58
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 528
Asp Thr Pro Ala Lys Ala Ala Gln Pro Gln Cys His Val Val Ser Trp 
1               5                   10                  15      


Ile Val Val Glu Arg Val Lys Trp Leu Ser Ser Ser Val Phe Asn Lys 
            20                  25                  30          


Gly Leu Lys Asp Ala Gln Lys Val Pro His Cys Met Gly Ser Asp Leu 
        35                  40                  45              


Gly Pro Arg Cys Thr Cys Phe Thr Cys Val 
    50                  55              


<210> 529
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 529
Ser Arg Leu Lys Lys Arg Leu Gly Pro Pro Asn His Gly Asp Val Val 
1               5                   10                  15      


Phe Leu 
        


<210> 530
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 530
Tyr Gly His Asn His Asp Glu Gln Gly Arg Gly Gly 
1               5                   10          


<210> 531
<211> 171
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 531
His Gly His His Gln Gly Val His Ala Leu Gln Gly Ala His Gly Gly 
1               5                   10                  15      


Leu Arg Glu Arg Pro Arg Val Arg Asp Arg Gly Arg Gly Arg Gly Pro 
            20                  25                  30          


Pro Leu Arg Gly His Pro Asp Arg Gln Ala Glu Gly Asp Gln Gly Trp 
        35                  40                  45              


Pro Pro Ala Leu Arg Leu Gly His Pro Val Pro Ser Val His Val Arg 
    50                  55                  60                  


Leu Gln Gly Leu Arg Glu Ala Pro Arg Arg His Pro Arg Leu Leu Glu 
65                  70                  75                  80  


Ala Val Leu Pro Arg Gly Leu Gln Val Gly Ala Arg Asp Glu Leu Arg 
                85                  90                  95      


Gly Arg Arg Arg Gly Asp Arg Asp Pro Gly Leu Leu Pro Ala Gly Arg 
            100                 105                 110         


Arg Val His Leu Gln Gly Glu Ala Ala Arg His Gln Leu Pro Leu Arg 
        115                 120                 125             


Arg Pro Arg Asn Ala Glu Glu Asp His Gly Leu Gly Gly Leu Leu Arg 
    130                 135                 140                 


Ala Asp Val Pro Arg Gly Arg Arg Pro Glu Gly Arg Asp Gln Ala Glu 
145                 150                 155                 160 


Ala Glu Ala Glu Gly Arg Arg Pro Leu Arg Arg 
                165                 170     


<210> 532
<211> 56
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 532
Gly Gln Asp His Leu Gln Gly Gln Glu Ala Arg Ala Ala Ala Arg Arg 
1               5                   10                  15      


Leu Gln Arg Gln His Gln Val Gly His His Leu Pro Gln Arg Gly Leu 
            20                  25                  30          


His His Arg Gly Thr Val Arg Thr Arg Arg Gly Pro Pro Leu His Arg 
        35                  40                  45              


Arg His Gly Arg Ala Val Gln Val 
    50                  55      


<210> 533
<211> 1188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      construct

<400> 533
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgtag                  1188


<210> 534
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 534
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210> 535
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 535
Gly Gly Gly Gly 
1               


<210> 536
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      linker

<400> 536
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


