                         SEQUENCE LISTING

<110>  Genentech, Inc.
       F. Hoffmann-La Roche AG
 
<120>  DIAGNOSTIC AND THERAPEUTIC METHODS FOR CANCER

<130>  50474-164WO4

<150>  US 62/572,979
<151>  2017-10-16

<150>  US 62/514,680
<151>  2017-06-02

<150>  US 62/465,547
<151>  2017-03-01

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  1975
<212>  RNA
<213>  Homo sapiens

<400>  1
acuuuccccc cucggcgccc caccggcucc cgcgcgccuc cccucgcgcc cgagcuucga       60

gccaagcagc guccugggga gcgcgucaug gccuuaccag ugaccgccuu gcuccugccg      120

cuggccuugc ugcuccacgc cgccaggccg agccaguucc gggugucgcc gcuggaucgg      180

accuggaacc ugggcgagac aguggagcug aagugccagg ugcugcuguc caacccgacg      240

ucgggcugcu cguggcucuu ccagccgcgc ggcgccgccg ccagucccac cuuccuccua      300

uaccucuccc aaaacaagcc caaggcggcc gaggggcugg acacccagcg guucucgggc      360

aagagguugg gggacaccuu cguccucacc cugagcgacu uccgccgaga gaacgagggc      420

uacuauuucu gcucggcccu gagcaacucc aucauguacu ucagccacuu cgugccgguc      480

uuccugccag cgaagcccac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      540

aucgcgucgc agccccuguc ccugcgccca gaggcgugcc ggccagcggc ggggggcgca      600

gugcacacga gggggcugga cuucgccugu gauaucuaca ucugggcgcc ccuggccggg      660

acuugugggg uccuucuccu gucacugguu aucacccuuu acugcaacca caggaaccga      720

agacguguuu gcaaaugucc ccggccugug gucaaaucgg gagacaagcc cagccuuucg      780

gcgagauacg ucuaacccug ugcaacagcc acuacauuac uucaaacuga gauccuuccu      840

uuugagggag caaguccuuc ccuuucauuu uuuccagucu uccucccugu guauucauuu      900

ucaugauuau uauuuuagug ggggcggggu gggaaagauu acuuuuucuu uauguguuug      960

acgggaaaca aaacuaggua aaaucuacag uacaccacaa gggucacaau acuguugugc     1020

gcacaucgcg guagggcgug gaaaggggca ggccagagcu acccgcagag uucucagaau     1080

caugcugaga gagcuggagg cacccaugcc aucucaaccu cuuccccgcc cguuuuacaa     1140

agggggaggc uaaagcccag agacagcuug aucaaaggca cacagcaagu caggguugga     1200

gcaguagcug gagggaccuu gucucccagc ucagggcucu uuccuccaca ccauucaggu     1260

cuuucuuucc gaggccccug ucucagggug aggugcuuga gucuccaacg gcaagggaac     1320

aaguacuucu ugauaccugg gauacugugc ccagagccuc gaggagguaa ugaauuaaag     1380

aagagaacug ccuuuggcag aguucuauaa uguaaacaau aucagacuuu uuuuuuuuau     1440

aaucaagccu aaaauuguau agaccuaaaa uaaaaugaag uggugagcuu aacccuggaa     1500

aaugaauccc ucuaucucua aagaaaaucu cugugaaacc ccuacgugga ggcggaauug     1560

cucucccagc ccuugcauug cagaggggcc caugaaagag gacaggcuac cccuuuacaa     1620

auagaauuug agcaucagug agguuaaacu aaggcccucu ugaaucucug aauuugagau     1680

acaaacaugu uccugggauc acugaugacu uuuuauacuu uguaaagaca auuguuggag     1740

agccccucac acagcccugg ccuccgcuca acuagcagau acagggauga ggcagaccug     1800

acucucuuaa ggaggcugag agcccaaacu gcugucccaa acaugcacuu ccuugcuuaa     1860

gguaugguac aagcaaugcc ugcccauugg agagaaaaaa cuuaaguaga uaaggaaaua     1920

agaaccacuc auaauucuuc accuuaggaa uaaucuccug uuaauauggu guaca          1975


<210>  2
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  3
<211>  2061
<212>  RNA
<213>  Homo sapiens

<400>  3
augcaguugg gagagcagcu cuuggugagc ucagugaacc ugccuggcgc gcacuucuac       60

ccgcuggaga gugcgcgagg cggcagcggc gggagcgcug gccaccuccc cagcgcggcc      120

cccucuccuc agaaguugga cuuaggcaaa gcguccaaga aguuuuccgg cagucucucc      180

ugcgaggcgg ugagcgggga gccugcagcc gccagcgcag gggcccccgc ggccaugcuu      240

agugacaccg acgccgggga cgcauuugcc agcgcugcgg caguggccaa gccggggccc      300

ccggacggcc gcaagggcuc ccccugcggg gaggaggagc ugcccuccgc cgcugcagcc      360

gccgccgccg ccgccgccgc ggcugcggcc acugcgcgcu acuccaugga cagccugagc      420

uccgugcggu acuaccucca gucccccggu ccucaggggu cggagcuggc ugcgcccugc      480

ucacucuucc cguaccaggc ggcggcuggg gcgccccacg gaccugugua cccggcuccu      540

aacggggcgc gcuaccccua cggcuccaug cugccccccg gcggcuuccc cgcggcugcg      600

ugcccacccg ggagggcgca guucggccca ggagccggug cgggcagugg cgcgggcggu      660

aucaacggcg ggggcggcgg cccgggcacc uaucaguaca gccagggggc uccgcucuac      720

gggccguacc cuggagccgc agcggcggga ucuugcggag gacugggggg ccuggggguu      780

ccaaguucug gcuuccgugc ccacgucuac cugugcaacc ggccucugug gcucaaauuc      840

caccggcacc aaacugagau gaucaucacc aaacagggca ggcgcauguu uccuuucuug      900

agcuucaaca uaaacggacu caaccccacc gcccacuaca auguuuucgu ggaagugguu      960

cuggccgacc cuaaccacug gcgcuuccag gggggcaaau gggugaccug uggcaaagcc     1020

gacaauaaca ugcagggcaa caaaauguau guucacccag agucuccuaa uacugguucc     1080

cacuggauga gacaggagau uucauucggg aaauuaaaac ucaccaauaa caaaggcgca     1140

aauaacaaca acacccagau gauagucuua caauccuuac acaaauacca accccgacug     1200

cauauuguug aaguuacaga ggauggcgug gaggacuuga augagcccuc aaagacccag     1260

acuuuuaccu ucucagaaac gcaauucauu gcagugacug ccuaccaaaa caccgauauu     1320

acucaacuaa agauugauca uaaccccuuu gcaaaaggcu ucagagacaa cuaugauuca     1380

ucccaucaga uugucccugg aggucgguac ggcguucaau ccuucuuccc ggagcccuuu     1440

gucaacacuu uaccucaagc ccgcuauuau aauggcgaga gaaccgugcc acagaccaac     1500

ggccuccuuu caccccaaca gagcgaagag guggccaacc cuccccagcg guggcuuguc     1560

acgccugucc agcaaccugg gaccaacaaa cuagacauca guuccuauga aucugaauau     1620

acuucuagca cauugcuccc auauggcauu aaauccuugc cccuucagac aucccaugcc     1680

cugggguauu acccagaccc aaccuuuccu gcaauggcag gguggggagg ucgagguucu     1740

uaccagagga agauggcagc uggacuacca uggaccucca gaacaagccc cacuguguuc     1800

ucugaagauc agcucuccaa ggagaaagug aaagaggaaa uuggcucuuc uuggauagag     1860

acacccccuu ccaucaaauc ucuagauucc aaugauucag gaguauacac cagugcuugu     1920

aagcgaaggc ggcugucucc uagcaacucc aguaaugaaa auucacccuc cauaaagugu     1980

ggggacauua augcugaaga guauaguaaa gacaccucaa aaggcauggg aggguauuau     2040

gcuuuuuaca caagucccua g                                               2061


<210>  4
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu Glu Val Ala 
            500                 505                 510         


Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln Pro Gly Thr 
        515                 520                 525             


Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr Ser Ser Thr 
    530                 535                 540                 


Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr Ser His Ala 
545                 550                 555                 560 


Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala Gly Trp Gly 
                565                 570                 575     


Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu Pro Trp Thr 
            580                 585                 590         


Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu Ser Lys Glu 
        595                 600                 605             


Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr Pro Pro Ser 
    610                 615                 620                 


Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr Ser Ala Cys 
625                 630                 635                 640 


Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu Asn Ser Pro 
                645                 650                 655     


Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser Lys Asp Thr 
            660                 665                 670         


Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr Pro 
        675                 680                 685     


<210>  5
<211>  1668
<212>  RNA
<213>  Homo sapiens

<400>  5
auggcagccc gucugcuccu ccugggcauc cuucuccugc ugcugccccu gcccgucccu       60

gccccgugcc acacagccgc acgcucagag ugcaagcgca gccacaaguu cgugccuggu      120

gcauggcugg ccggggaggg uguggacgug accagccucc gccgcucggg cuccuuccca      180

guggacacac aaagguuccu gcggcccgac ggcaccugca cccucuguga aaaugcccua      240

caggagggca cccuccagcg ccugccucug gcgcucacca acuggcgggc ccagggcucu      300

ggcugccagc gccauguaac cagggccaaa gucagcucca cugaagcugu ggcccgggau      360

gcggcucgua gcauccgcaa cgacuggaag gucgggcugg acgugacucc uaagcccacc      420

agcaaugugc augugucugu ggccggcuca cacucacagg cagccaacuu ugcagcccag      480

aagacccacc aggaccagua cagcuucagc acugacacgg uggagugccg cuucuacagu      540

uuccaugugg uacacacucc cccgcugcac ccugacuuca agagggcccu cggggaccug      600

ccccaccacu ucaacgccuc cacccagccc gccuaccuca ggcuuaucuc caacuacggc      660

acccacuuca uccgggcugu ggagcugggu ggccgcauau cggcccucac ugcccugcgc      720

accugcgagc uggcccugga agggcucacg gacaacgagg uggaggacug ccugacuguc      780

gaggcccagg ucaacauagg cauccacggc agcaucucug ccgaagccaa ggccugugag      840

gagaagaaga agaagcacaa gaugacggcc uccuuccacc aaaccuaccg ggagcgccac      900

ucggaagugg uuggcggcca ucacaccucc auuaacgacc ugcuguucgg gauccaggcc      960

gggcccgagc aguacucagc cuggguaaac uccgugcccg gcagcccugg ccugguggac     1020

uacacccugg aaccccugca cgugcugcug gacagccagg acccgcggcg ggaggcacug     1080

aggagggccc ugagucagua ccugacggac agggcucgcu ggagggacug cagccggccg     1140

ugcccaccag ggcggcagaa gagcccccga gacccaugcc agugugugug ccauggcuca     1200

gcggucacca cccaggacug cugcccucgg cagaggggcc uggcccagcu ggaggugacc     1260

uucauccaag cauggagccu guggggggac ugguucacug ccacggaugc cuaugugaag     1320

cucuucuuug guggccagga gcugaggacg agcaccgugu gggacaauaa caaccccauc     1380

uggucagugc ggcuggauuu uggggaugug cuccuggcca caggggggcc ccugagguug     1440

caggucuggg aucaggacuc uggcagggac gaugaccucc uuggcaccug ugaucaggcu     1500

cccaagucug guucccauga ggugagaugc aaccugaauc auggccaccu aaaauuccgc     1560

uaucaugcca ggugcuugcc ccaccuggga ggaggcaccu gccuggacua ugucccccaa     1620

augcuucugg gggagccucc aggaaaccgg aguggggccg ugugguga                  1668


<210>  6
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Arg Leu Leu Leu Leu Gly Ile Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Pro Val Pro Ala Pro Cys His Thr Ala Ala Arg Ser Glu Cys Lys 
            20                  25                  30          


Arg Ser His Lys Phe Val Pro Gly Ala Trp Leu Ala Gly Glu Gly Val 
        35                  40                  45              


Asp Val Thr Ser Leu Arg Arg Ser Gly Ser Phe Pro Val Asp Thr Gln 
    50                  55                  60                  


Arg Phe Leu Arg Pro Asp Gly Thr Cys Thr Leu Cys Glu Asn Ala Leu 
65                  70                  75                  80  


Gln Glu Gly Thr Leu Gln Arg Leu Pro Leu Ala Leu Thr Asn Trp Arg 
                85                  90                  95      


Ala Gln Gly Ser Gly Cys Gln Arg His Val Thr Arg Ala Lys Val Ser 
            100                 105                 110         


Ser Thr Glu Ala Val Ala Arg Asp Ala Ala Arg Ser Ile Arg Asn Asp 
        115                 120                 125             


Trp Lys Val Gly Leu Asp Val Thr Pro Lys Pro Thr Ser Asn Val His 
    130                 135                 140                 


Val Ser Val Ala Gly Ser His Ser Gln Ala Ala Asn Phe Ala Ala Gln 
145                 150                 155                 160 


Lys Thr His Gln Asp Gln Tyr Ser Phe Ser Thr Asp Thr Val Glu Cys 
                165                 170                 175     


Arg Phe Tyr Ser Phe His Val Val His Thr Pro Pro Leu His Pro Asp 
            180                 185                 190         


Phe Lys Arg Ala Leu Gly Asp Leu Pro His His Phe Asn Ala Ser Thr 
        195                 200                 205             


Gln Pro Ala Tyr Leu Arg Leu Ile Ser Asn Tyr Gly Thr His Phe Ile 
    210                 215                 220                 


Arg Ala Val Glu Leu Gly Gly Arg Ile Ser Ala Leu Thr Ala Leu Arg 
225                 230                 235                 240 


Thr Cys Glu Leu Ala Leu Glu Gly Leu Thr Asp Asn Glu Val Glu Asp 
                245                 250                 255     


Cys Leu Thr Val Glu Ala Gln Val Asn Ile Gly Ile His Gly Ser Ile 
            260                 265                 270         


Ser Ala Glu Ala Lys Ala Cys Glu Glu Lys Lys Lys Lys His Lys Met 
        275                 280                 285             


Thr Ala Ser Phe His Gln Thr Tyr Arg Glu Arg His Ser Glu Val Val 
    290                 295                 300                 


Gly Gly His His Thr Ser Ile Asn Asp Leu Leu Phe Gly Ile Gln Ala 
305                 310                 315                 320 


Gly Pro Glu Gln Tyr Ser Ala Trp Val Asn Ser Leu Pro Gly Ser Pro 
                325                 330                 335     


Gly Leu Val Asp Tyr Thr Leu Glu Pro Leu His Val Leu Leu Asp Ser 
            340                 345                 350         


Gln Asp Pro Arg Arg Glu Ala Leu Arg Arg Ala Leu Ser Gln Tyr Leu 
        355                 360                 365             


Thr Asp Arg Ala Arg Trp Arg Asp Cys Ser Arg Pro Cys Pro Pro Gly 
    370                 375                 380                 


Arg Gln Lys Ser Pro Arg Asp Pro Cys Gln Cys Val Cys His Gly Ser 
385                 390                 395                 400 


Ala Val Thr Thr Gln Asp Cys Cys Pro Arg Gln Arg Gly Leu Ala Gln 
                405                 410                 415     


Leu Glu Val Thr Phe Ile Gln Ala Trp Gly Leu Trp Gly Asp Trp Phe 
            420                 425                 430         


Thr Ala Thr Asp Ala Tyr Val Lys Leu Phe Phe Gly Gly Gln Glu Leu 
        435                 440                 445             


Arg Thr Ser Thr Val Trp Asp Asn Asn Asn Pro Ile Trp Ser Val Arg 
    450                 455                 460                 


Leu Asp Phe Gly Asp Val Leu Leu Ala Thr Gly Gly Pro Leu Arg Leu 
465                 470                 475                 480 


Gln Val Trp Asp Gln Asp Ser Gly Arg Asp Asp Asp Leu Leu Gly Thr 
                485                 490                 495     


Cys Asp Gln Ala Pro Lys Ser Gly Ser His Glu Val Arg Cys Asn Leu 
            500                 505                 510         


Asn His Gly His Leu Lys Phe Arg Tyr His Ala Arg Cys Leu Pro His 
        515                 520                 525             


Leu Gly Gly Gly Thr Cys Leu Asp Tyr Val Pro Gln Met Leu Leu Gly 
    530                 535                 540                 


Glu Pro Pro Gly Asn Arg Ser Gly Ala Val Trp 
545                 550                 555 


<210>  7
<211>  1193
<212>  RNA
<213>  Homo sapiens

<400>  7
ugaagaucag cuauuagaag agaaagauca guuaaguccu uuggaccuga ucagcuugau       60

acaagaacua cugauuucaa cuucuuuggc uuaauucucu cggaaacgau gaaauauaca      120

aguuauaucu uggcuuuuca gcucugcauc guuuuggguu cucuuggcug uuacugccag      180

gacccauaug uaaaagaagc agaaaaccuu aagaaauauu uuaaugcagg ucauucagau      240

guagcggaua auggaacucu uuucuuaggc auuuugaaga auuggaaaga ggagagugac      300

agaaaaauaa ugcagagcca aauugucucc uuuuacuuca aacuuuuuaa aaacuuuaaa      360

gaugaccaga gcauccaaaa gaguguggag accaucaagg aagacaugaa ugucaaguuu      420

uucaauagca acaaaaagaa acgagaugac uucgaaaagc ugacuaauua uucgguaacu      480

gacuugaaug uccaacgcaa agcaauacau gaacucaucc aagugauggc ugaacugucg      540

ccagcagcua aaacagggaa gcgaaaaagg agucagaugc uguuucaagg ucgaagagca      600

ucccaguaau gguuguccug ccugcaauau uugaauuuua aaucuaaauc uauuuauuaa      660

uauuuaacau uauuuauaug gggaauauau uuuuagacuc aucaaucaaa uaaguauuua      720

uaauagcaac uuuuguguaa ugaaaaugaa uaucuauuaa uauauguauu auuuauaauu      780

ccuauauccu gugacugucu cacuuaaucc uuuguuuucu gacuaauuag gcaaggcuau      840

gugauuacaa ggcuuuaucu caggggccaa cuaggcagcc aaccuaagca agaucccaug      900

gguugugugu uuauuucacu ugaugauaca augaacacuu auaagugaag ugauacuauc      960

caguuacugc cgguuugaaa auaugccugc aaucugagcc agugcuuuaa uggcauguca     1020

gacagaacuu gaauguguca ggugacccug augaaaacau agcaucucag gagauuucau     1080

gccuggugcu uccaaauauu guugacaacu gugacuguac ccaaauggaa aguaacucau     1140

uuguuaaaau uaucaauauc uaauauauau gaauaaagug uaaguucaca acu            1193


<210>  8
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  9
<211>  5830
<212>  RNA
<213>  Homo sapiens

<400>  9
acugaguccc gggaccccgg gagagcgguc aguguguggu cgcugcguuu ccucugccug       60

cgccgggcau cacuugcgcg ccgcagaaag uccgucuggc agccuggaua uccucuccua      120

ccggcacccg cagacgcccc ugcagccgcc ggucggcgcc cgggcucccu agcccugugc      180

gcucaacugu ccugcgcugc ggggugccgc gaguuccacc uccgcgccuc cuucucuaga      240

caggcgcugg gagaaagaac cggcucccga guucugggca uuucgcccgg cucgaggugc      300

aggaugcaga gcaaggugcu gcuggccguc gcccuguggc ucugcgugga gacccgggcc      360

gccucugugg guuugccuag uguuucucuu gaucugccca ggcucagcau acaaaaagac      420

auacuuacaa uuaaggcuaa uacaacucuu caaauuacuu gcaggggaca gagggacuug      480

gacuggcuuu ggcccaauaa ucagaguggc agugagcaaa ggguggaggu gacugagugc      540

agcgauggcc ucuucuguaa gacacucaca auuccaaaag ugaucggaaa ugacacugga      600

gccuacaagu gcuucuaccg ggaaacugac uuggccucgg ucauuuaugu cuauguucaa      660

gauuacagau cuccauuuau ugcuucuguu agugaccaac auggagucgu guacauuacu      720

gagaacaaaa acaaaacugu ggugauucca ugucucgggu ccauuucaaa ucucaacgug      780

ucacuuugug caagauaccc agaaaagaga uuuguuccug augguaacag aauuuccugg      840

gacagcaaga agggcuuuac uauucccagc uacaugauca gcuaugcugg cauggucuuc      900

ugugaagcaa aaauuaauga ugaaaguuac cagucuauua uguacauagu ugucguugua      960

ggguauagga uuuaugaugu gguucugagu ccgucucaug gaauugaacu aucuguugga     1020

gaaaagcuug ucuuaaauug uacagcaaga acugaacuaa auguggggau ugacuucaac     1080

ugggaauacc cuucuucgaa gcaucagcau aagaaacuug uaaaccgaga ccuaaaaacc     1140

cagucuggga gugagaugaa gaaauuuuug agcaccuuaa cuauagaugg uguaacccgg     1200

agugaccaag gauuguacac cugugcagca uccagugggc ugaugaccaa gaagaacagc     1260

acauuuguca ggguccauga aaaaccuuuu guugcuuuug gaaguggcau ggaaucucug     1320

guggaagcca cgguggggga gcgugucaga aucccugcga aguaccuugg uuacccaccc     1380

ccagaaauaa aaugguauaa aaauggaaua ccccuugagu ccaaucacac aauuaaagcg     1440

gggcauguac ugacgauuau ggaagugagu gaaagagaca caggaaauua cacugucauc     1500

cuuaccaauc ccauuucaaa ggagaagcag agccaugugg ucucucuggu uguguauguc     1560

ccaccccaga uuggugagaa aucucuaauc ucuccugugg auuccuacca guacggcacc     1620

acucaaacgc ugacauguac ggucuaugcc auuccucccc cgcaucacau ccacugguau     1680

uggcaguugg aggaagagug cgccaacgag cccagccaag cugucucagu gacaaaccca     1740

uacccuugug aagaauggag aaguguggag gacuuccagg gaggaaauaa aauugaaguu     1800

aauaaaaauc aauuugcucu aauugaagga aaaaacaaaa cuguaaguac ccuuguuauc     1860

caagcggcaa augugucagc uuuguacaaa ugugaagcgg ucaacaaagu cgggagagga     1920

gagaggguga ucuccuucca cgugaccagg gguccugaaa uuacuuugca accugacaug     1980

cagcccacug agcaggagag cgugucuuug uggugcacug cagacagauc uacguuugag     2040

aaccucacau gguacaagcu uggcccacag ccucugccaa uccauguggg agaguugccc     2100

acaccuguuu gcaagaacuu ggauacucuu uggaaauuga augccaccau guucucuaau     2160

agcacaaaug acauuuugau cauggagcuu aagaaugcau ccuugcagga ccaaggagac     2220

uaugucugcc uugcucaaga caggaagacc aagaaaagac auugcguggu caggcagcuc     2280

acaguccuag agcguguggc acccacgauc acaggaaacc uggagaauca gacgacaagu     2340

auuggggaaa gcaucgaagu cucaugcacg gcaucuggga aucccccucc acagaucaug     2400

ugguuuaaag auaaugagac ccuuguagaa gacucaggca uuguauugaa ggaugggaac     2460

cggaaccuca cuauccgcag agugaggaag gaggacgaag gccucuacac cugccaggca     2520

ugcaguguuc uuggcugugc aaaaguggag gcauuuuuca uaauagaagg ugcccaggaa     2580

aagacgaacu uggaaaucau uauucuagua ggcacggcgg ugauugccau guucuucugg     2640

cuacuucuug ucaucauccu acggaccguu aagcgggcca auggagggga acugaagaca     2700

ggcuacuugu ccaucgucau ggauccagau gaacucccau uggaugaaca uugugaacga     2760

cugccuuaug augccagcaa augggaauuc cccagagacc ggcugaagcu agguaagccu     2820

cuuggccgug gugccuuugg ccaagugauu gaagcagaug ccuuuggaau ugacaagaca     2880

gcaacuugca ggacaguagc agucaaaaug uugaaagaag gagcaacaca cagugagcau     2940

cgagcucuca ugucugaacu caagauccuc auucauauug gucaccaucu caaugugguc     3000

aaccuucuag gugccuguac caagccagga gggccacuca uggugauugu ggaauucugc     3060

aaauuuggaa accuguccac uuaccugagg agcaagagaa augaauuugu ccccuacaag     3120

accaaagggg cacgauuccg ucaagggaaa gacuacguug gagcaauccc uguggaucug     3180

aaacggcgcu uggacagcau caccaguagc cagagcucag ccagcucugg auuuguggag     3240

gagaaguccc ucagugaugu agaagaagag gaagcuccug aagaucugua uaaggacuuc     3300

cugaccuugg agcaucucau cuguuacagc uuccaagugg cuaagggcau ggaguucuug     3360

gcaucgcgaa aguguaucca cagggaccug gcggcacgaa auauccucuu aucggagaag     3420

aacgugguua aaaucuguga cuuuggcuug gcccgggaua uuuauaaaga uccagauuau     3480

gucagaaaag gagaugcucg ccucccuuug aaauggaugg ccccagaaac aauuuuugac     3540

agaguguaca caauccagag ugacgucugg ucuuuuggug uuuugcugug ggaaauauuu     3600

uccuuaggug cuucuccaua uccuggggua aagauugaug aagaauuuug uaggcgauug     3660

aaagaaggaa cuagaaugag ggccccugau uauacuacac cagaaaugua ccagaccaug     3720

cuggacugcu ggcacgggga gcccagucag agacccacgu uuucagaguu gguggaacau     3780

uugggaaauc ucuugcaagc uaaugcucag caggauggca aagacuacau uguucuuccg     3840

auaucagaga cuuugagcau ggaagaggau ucuggacucu cucugccuac cucaccuguu     3900

uccuguaugg aggaggagga aguaugugac cccaaauucc auuaugacaa cacagcagga     3960

aucagucagu aucugcagaa caguaagcga aagagccggc cugugagugu aaaaacauuu     4020

gaagauaucc cguuagaaga accagaagua aaaguaaucc cagaugacaa ccagacggac     4080

agugguaugg uucuugccuc agaagagcug aaaacuuugg aagacagaac caaauuaucu     4140

ccaucuuuug guggaauggu gcccagcaaa agcagggagu cuguggcauc ugaaggcuca     4200

aaccagacaa gcggcuacca guccggauau cacuccgaug acacagacac caccguguac     4260

uccagugagg aagcagaacu uuuaaagcug auagagauug gagugcaaac cgguagcaca     4320

gcccagauuc uccagccuga cucggggacc acacugagcu cuccuccugu uuaaaaggaa     4380

gcauccacac cccaacuccc ggacaucaca ugagaggucu gcucagauuu ugaaguguug     4440

uucuuuccac cagcaggaag uagccgcauu ugauuuucau uucgacaaca gaaaaaggac     4500

cucggacugc agggagccag ucuucuaggc auauccugga agaggcuugu gacccaagaa     4560

ugugucugug ucuucuccca guguugaccu gauccucuuu uuucauucau uuaaaaagca     4620

uuaucaugcc ccugcugcgg gucucaccau ggguuuagaa caaagagcuu caagcaaugg     4680

ccccauccuc aaagaaguag caguaccugg ggagcugaca cuucuguaaa acuagaagau     4740

aaaccaggca acguaagugu ucgagguguu gaagauggga aggauuugca gggcugaguc     4800

uauccaagag gcuuuguuua ggacgugggu cccaagccaa gccuuaagug uggaauucgg     4860

auugauagaa aggaagacua acguuaccuu gcuuuggaga guacuggagc cugcaaaugc     4920

auuguguuug cucuggugga ggugggcaug gggucuguuc ugaaauguaa aggguucaga     4980

cgggguuucu gguuuuagaa gguugcgugu ucuucgaguu gggcuaaagu agaguucguu     5040

gugcuguuuc ugacuccuaa ugagaguucc uuccagaccg uuagcugucu ccuugccaag     5100

ccccaggaag aaaaugaugc agcucuggcu ccuugucucc caggcugauc cuuuauucag     5160

aauaccacaa agaaaggaca uucagcucaa ggcucccugc cguguugaag aguucugacu     5220

gcacaaacca gcuucugguu ucuucuggaa ugaauacccu cauaucuguc cugaugugau     5280

augucugaga cugaaugcgg gagguucaau gugaagcugu gugugguguc aaaguuucag     5340

gaaggauuuu acccuuuugu ucuucccccu guccccaacc cacucucacc ccgcaaccca     5400

ucaguauuuu aguuauuugg ccucuacucc aguaaaccug auuggguuug uucacucucu     5460

gaaugauuau uagccagacu ucaaaauuau uuuauagccc aaauuauaac aucuauugua     5520

uuauuuagac uuuuaacaua uagagcuauu ucuacugauu uuugcccuug uucuguccuu     5580

uuuuucaaaa aagaaaaugu guuuuuuguu ugguaccaua gugugaaaug cugggaacaa     5640

ugacuauaag acaugcuaug gcacauauau uuauagucug uuuauguaga aacaaaugua     5700

auauauuaaa gccuuauaua uaaugaacuu uguacuauuc acauuuugua ucaguauuau     5760

guagcauaac aaaggucaua augcuuucag caauugaugu cauuuuauua aagaacauug     5820

aaaaacuuga                                                            5830


<210>  10
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  11
<211>  2089
<212>  RNA
<213>  Homo sapiens

<400>  11
aguuuggacg gcugcuuccc accagcaaag accacgacug gagagccgag ccggaggcag       60

cugggaaaca ugaagagcgu cuugcugcug accacgcucc ucgugccugc acaccuggug      120

gccgccugga gcaauaauua ugcgguggac ugcccucaac acugugacag cagugagugc      180

aaaagcagcc cgcgcugcaa gaggacagug cucgacgacu guggcugcug ccgagugugc      240

gcugcagggc ggggagaaac uugcuaccgc acagucucag gcauggaugg caugaagugu      300

ggcccggggc ugagguguca gccuucuaau ggggaggauc cuuuugguga agaguuuggu      360

aucugcaaag acugucccua cggcaccuuc gggauggauu gcagagagac cugcaacugc      420

cagucaggca ucugugacag ggggacggga aaaugccuga aauuccccuu cuuccaauau      480

ucaguaacca agucuuccaa cagauuuguu ucucucacgg agcaugacau ggcaucugga      540

gauggcaaua uugugagaga agaaguugug aaagagaaug cugccggguc ucccguaaug      600

aggaaauggu uaaauccacg cugaucccgg cugugauuuc ugagagaagg cucuauuuuc      660

gugauuguuc aacacacagc caacauuuua ggaacuuucu agauuauagc auaaggacau      720

guaauuuuug aagaccaaau gugaugcaug guggauccag aaaacaaaaa guaggauacu      780

uacaauccau aacauccaua ugacugaaca cuuguaugug uuuguuaaau auucgaaugc      840

auguagauuu guuaaaugug uguguauagu aacacugaag aacuaaaaau gcaauuuagg      900

uaaucuuacg uggagacagg ucaaccaaag agggagcuag gcaaagcuga agaccgcagu      960

gagucaaauu aguucuuuga cuuugaugua cauuaauguu gggauaugga augaagacuu     1020

aagagcagga gaagaugggg aggggguggg agugggaaau aaaauauuua gcccuuccuu     1080

gguagguagc uucucuagaa uuuaauugug cuuuuuuuuu uuuuuuuggc uuugggaaaa     1140

gucaaaauaa aacaaccaga aaaccccuga aggaaguaag auguuugaag cuuauggaaa     1200

uuugaguaac aaacagcuuu gaacugagag caauuucaaa aggcugcuga uguaguuccc     1260

ggguuaccug uaucugaagg acgguucugg ggcauaggaa acacauacac uuccauaaau     1320

agcuuuaacg uaugccaccu cagagauaaa ucuaagaagu auuuuaccca cuggugguuu     1380

guguguguau gaagguaaau auuuauauau uuuuauaaau aaauguguua gugcaaguca     1440

ucuucccuac ccauauuuau cauccucuug aggaaagaaa ucuaguauua uuuguugaaa     1500

augguuagaa uaaaacuaug acucuauaag guuuucaaac aucugaggca ugauaaauuu     1560

auuauccaua auuauaguaa uaauaaccuu aauaagcaua agaaaaacag agucacucug     1620

gauuucaaaa augucaaaaa augagcaaca gaggguccuu auuuaaacau aagugcugug     1680

acuuagguga auuuucaauu uaagguagaa aauaaguuuu uaggagguuu guaaaagaag     1740

aaucaauuuu cagcagaaaa caugucaacu uuaaaauaua guuuauuuuc auauuuuuuu     1800

cuuuuaaacu ugguugauaa guggaauuag gaguauauuu gaaagaaucu uagcacaaac     1860

aggacuguug uacuagaugu ucuuaggaaa uaucucagaa guauuuuauu ugaagugaag     1920

aacuuauuua agaauuauuu caguauuuac cuguauuuua uucuugaagu uggccaacag     1980

aguugugaau guguguggga aggccuuuga auguaaagcu gcauaagcug uuagguuuug     2040

uuuuaaaagg acauguuuau uauuguucaa uaaaaaagaa caagauaca                 2089


<210>  12
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Ser Val Leu Leu Leu Thr Thr Leu Leu Val Pro Ala His Leu 
1               5                   10                  15      


Val Ala Ala Trp Ser Asn Asn Tyr Ala Val Asp Cys Pro Gln His Cys 
            20                  25                  30          


Asp Ser Ser Glu Cys Lys Ser Ser Pro Arg Cys Lys Arg Thr Val Leu 
        35                  40                  45              


Asp Asp Cys Gly Cys Cys Arg Val Cys Ala Ala Gly Arg Gly Glu Thr 
    50                  55                  60                  


Cys Tyr Arg Thr Val Ser Gly Met Asp Gly Met Lys Cys Gly Pro Gly 
65                  70                  75                  80  


Leu Arg Cys Gln Pro Ser Asn Gly Glu Asp Pro Phe Gly Glu Glu Phe 
                85                  90                  95      


Gly Ile Cys Lys Asp Cys Pro Tyr Gly Thr Phe Gly Met Asp Cys Arg 
            100                 105                 110         


Glu Thr Cys Asn Cys Gln Ser Gly Ile Cys Asp Arg Gly Thr Gly Lys 
        115                 120                 125             


Cys Leu Lys Phe Pro Phe Phe Gln Tyr Ser Val Thr Lys Ser Ser Asn 
    130                 135                 140                 


Arg Phe Val Ser Leu Thr Glu His Asp Met Ala Ser Gly Asp Gly Asn 
145                 150                 155                 160 


Ile Val Arg Glu Glu Val Val Lys Glu Asn Ala Ala Gly Ser Pro Val 
                165                 170                 175     


Met Arg Lys Trp Leu Asn Pro Arg 
            180                 


<210>  13
<211>  6831
<212>  RNA
<213>  Homo sapiens

<400>  13
ccaggcccca uuguucccgg uuuccagcca uggcugccau uaccugacca gcgccacagc       60

cggucucucu gcaggcgccg ggagaaguga ccagagcaau uucugcuuuu cacagggcgg      120

guuucucaac ggugacuugu gggcagugcc uucugcugag cgagucaugg cccgaaggca      180

gaacuaacug ugccugcagu cuucacucuc aggaugcagc cgaggugggc ccaaggggcc      240

acgauguggc uuggaguccu gcugacccuu cugcucuguu caagccuuga gggucaagaa      300

aacucuuuca caaucaacag uguugacaug aagagccugc cggacuggac ggugcaaaau      360

gggaagaacc ugacccugca gugcuucgcg gaugucagca ccaccucuca cgucaagccu      420

cagcaccaga ugcuguucua uaaggaugac gugcuguuuu acaacaucuc cuccaugaag      480

agcacagaga guuauuuuau uccugaaguc cggaucuaug acucagggac auauaaaugu      540

acugugauug ugaacaacaa agagaaaacc acugcagagu accagguguu gguggaagga      600

gugcccaguc ccagggugac acuggacaag aaagaggcca uccaaggugg gaucgugagg      660

gucaacuguu cugucccaga ggaaaaggcc ccaauacacu ucacaauuga aaaacuugaa      720

cuaaaugaaa aaauggucaa gcugaaaaga gagaagaauu cucgagacca gaauuuugug      780

auacuggaau uccccguuga ggaacaggac cgcguuuuau ccuuccgaug ucaagcuagg      840

aucauuucug ggauccauau gcagaccuca gaaucuacca agagugaacu ggucaccgug      900

acggaauccu ucucuacacc caaguuccac aucagcccca ccggaaugau cauggaagga      960

gcucagcucc acauuaagug caccauucaa gugacucacc uggcccagga guuuccagaa     1020

aucauaauuc agaaggacaa ggcgauugug gcccacaaca gacauggcaa caaggcugug     1080

uacucaguca uggccauggu ggagcacagu ggcaacuaca cgugcaaagu ggaguccagc     1140

cgcauaucca aggucagcag caucgugguc aacauaacag aacuauuuuc caagcccgaa     1200

cuggaaucuu ccuucacaca ucuggaccaa ggugaaagac ugaaccuguc cugcuccauc     1260

ccaggagcac cuccagccaa cuucaccauc cagaaggaag auacgauugu gucacagacu     1320

caagauuuca ccaagauagc cucaaagucg gacaguggga cguauaucug cacugcaggu     1380

auugacaaag uggucaagaa aagcaacaca guccagauag ucguauguga aaugcucucc     1440

cagcccagga uuucuuauga ugcccaguuu gaggucauaa aaggacagac caucgaaguc     1500

cguugcgaau cgaucagugg aacuuugccu auuucuuacc aacuuuuaaa aacaaguaaa     1560

guuuuggaga auaguaccaa gaacucaaau gauccugcgg uauucaaaga caaccccacu     1620

gaagacgucg aauaccagug uguugcagau aauugccauu cccaugccaa aauguuaagu     1680

gagguucuga gggugaaggu gauagccccg guggaugagg uccagauuuc uauccuguca     1740

aguaaggugg uggagucugg agaggacauu gugcugcaau gugcugugaa ugaaggaucu     1800

ggucccauca ccuauaaguu uuacagagaa aaagagggca aacccuucua ucaaaugacc     1860

ucaaaugcca cccaggcauu uuggaccaag cagaaggcua gcaaggaaca ggagggagag     1920

uauuacugca cagccuucaa cagagccaac cacgccucca guguccccag aagcaaaaua     1980

cugacaguca gagucauucu ugccccaugg aagaaaggac uuauugcagu gguuaucauc     2040

ggagugauca uugcucucuu gaucauugcg gccaaauguu auuuucugag gaaagccaag     2100

gccaagcaga ugccagugga aauguccagg ccagcaguac cacuucugaa cuccaacaac     2160

gagaaaaugu cagaucccaa uauggaagcu aacagucauu acggucacaa ugacgauguc     2220

agaaaccaug caaugaaacc aauaaaugau aauaaagagc cucugaacuc agacgugcag     2280

uacacggaag uucaaguguc cucagcugag ucucacaaag aucuaggaaa gaaggacaca     2340

gagacagugu acagugaagu ccggaaagcu gucccugaug ccguggaaag cagauacucu     2400

agaacggaag gcucccuuga uggaacuuag acagcaaggc cagaugcaca ucccuggaag     2460

gacauccaug uuccgagaag aacagauaau cccuguauuu caagaccucu gugcacuuau     2520

uuaugaaccu gcccugcucc cacagaacac agcaauuccu caggcuaagc ugccgguucu     2580

uaaauccauc cugcuaaguu aauguugggu agaaagagau acagaggggc uguugaauuu     2640

cccacauacc cuccuuccac caaguuggaa cauccuugga aauuggaaga gcacaagagg     2700

agauccaggg caaggccauu gggauauucu gaaacuugaa uauuuuguuu ugugcagaga     2760

uaaagaccuu uuccaugcac ccucauacac agaaaccaau uuucuuuuuu auacucaauc     2820

auuucuagcg cauggccugg uuagaggcug guuuuuucuc uuuuccuuug guccuucaaa     2880

ggcuuguagu uuuggcuagu ccuuguucuu uggaaauaca cagugcugac cagacagccu     2940

cccccugucc ccucuaugac cucgcccucc acaaauggga aaaccagacu acuugggagc     3000

accgccugug aaauaccaac cugaagacac cguucauuca ggcaacgcac aaaacagaaa     3060

augaaggugg aacaagcaca gauguucuuc aacuguuuuu gucuacacuc uuucucuuuu     3120

ccucuaccau gcugaaggcu gaaagacagg aagauggugc caucagcaaa uauuauucuu     3180

aauugaaaac uugaaaugug uauguuucuu acuaauuuuu aaaaauguau uccuugccag     3240

ggcaggcaag guggcucacg ccuguaaucc cagcacuuca ggaggcugag gugggcggau     3300

caccugaggu caggaguuug agaccagccu gaugaaaccc ugucucuacu aaaaauacaa     3360

gaauuagccg ggcguggugg cgcaugccug uaguaucagc uacucaagag gcugagguga     3420

gauuaucgcu ugaacccagg aaacggaggu uguagugagc ggagaucgcg ccacugcacu     3480

ccagccugag ugacagagug agaauccauc ucaaaaaaaa caaaaaacaa aauugcuugc     3540

uaaagaagug gucuccugag gucuuaagac auuccugaca gugucuugag ugggugggag     3600

agaggcugcu gucauugcgc uguggaauuu cacagaugag aaccacgccu agccaaaauc     3660

acuuuuccug uuugccucag ugacacagcu gcagggaccc ucguggaugu uguauuaaau     3720

aaauuugacc uuugcucuuu gcagaucugu gaaauguugu cuucugaggg gccacaugca     3780

ucuauagugc ugaggacucc uugggccucu gaagucacag agagaaccga gcaggucuau     3840

guuuuuguuu uguuguuuug agacggagau ucgcucuugu ugcccgggcu ggacugcagc     3900

ggcgcaaccu cugcucacug caaccuccgc cuccuggguu caagcaguuc uccugucuca     3960

gccucccgag uagcugggau uacaggcaca ugucaccacg ccuggcuaau uuuuguauuu     4020

uuaguagaga ugggguuuca ccacguuggc caggcugauc ucgaaugccu gaccuuuggu     4080

gaucugcccg ccuuguccuc augugugcuc cacaggccuu uggguuggga uugcaggcgu     4140

gagccaccau gcccagccua gacucuuuug acaauaugau gaaagcuguu gguuccuuuc     4200

cccaacacac acacaccgag uuguaucacg aaaaugucau acaauuucca gguuuucuga     4260

guggugggcu cagauugagg ucaaaggauc agacgaccuc uaacgaccuu caugucucug     4320

uugaugaucu ggggacagcc agauccccug uguccaggga guuccuuagu cccuugccac     4380

caccagagaa gggcaauugc cacgggagcu gcaaagaccc uauuccuacu ccuggugccu     4440

uacuuaugca gcacgacuga auuuuuuguu uuguuuuguu uuguugagac aggggcuugc     4500

ucuguugccc aggcuggagu gcaguggcac aacaauggcu caccgcagcc ucgaaccccu     4560

gggcucaagc gauccuccca ucucagcuuc cuggguagcu gggaccagag gcgugagccg     4620

ccauagcugg cuaauuuuua auuuuuuuuu ugcagagaug agguuucacc auggugccca     4680

ggcuggucuc gaacuucugg gcucaaguga uccucccucc uuggccucgc aaagugcugg     4740

gauugcaggc augagccacc gcccccggcc uguggagcac acaugaguuu aaaauuacuu     4800

ucccuucugc cuauauuucc gaggaggaaa cuucaugcgc agggaucuuu cuuaguggau     4860

uuaauggcua aaaggucugu cugaauccag gacgcuggcu uuagccuucc ucggcagcug     4920

ccguaacccc ggugucuaaa ccugaagcau cccaggagca cccacuccag gaguuuucuc     4980

ggccgcggaa cucauuaguu agagcgcccu cuuguguucu caugugguaa ucggucacug     5040

aaggacuuaa aaugguccuu agccaacaca caguaaaacu uuucccucuu cugaccccaa     5100

gaggucagcc acccauuuca ugagcauaua cuggucgccc caucagcguu cucugauugg     5160

cuaacugaac ccacuccccg accuagacuc aagacaggcg aagugacgcu uaggucaaca     5220

uucacucacu aaagcaacga cugucgggcg auuuugucuc ccgcugguuu uggaauggug     5280

ucuggagaca uuuuugguug ucacagcugg gugggugugc ucccggcauc ugguggguag     5340

aaaccaagca ugcuccuaaa cauccuacag gcacagaacc gucucccacg accaagcaug     5400

aucaaguccc aaaugccaau aauggccagg uugagaaacu cugcacagaa gcauccaguu     5460

auuugucugu uugcucaaca agcuugugcu caucaugcuc uguguuccug acgcugugcu     5520

ggguguuggc ggugggaaga uuacaagagu cacauggcag cuguccuccu ggaagguaca     5580

acccaguaga gaugcagacu aacagagagc caauuacaaa gcagugugac aagcgucaug     5640

guggaaaauu aaaagcucaa acaagggcac augggagggg cuuccaacac agacuuuggg     5700

ggauccagga aggucuaaga ggaaaguggg ucucaccaaa gccuugacca uaggcagagg     5760

guaccagugg aaaagguggg gugaagaaca uugaggacaa aaggaagaag ugcaggaagg     5820

cccugaggca agggaguggg gggugcccug gagggauggc agcagggcag ucugucagac     5880

ccaaguggcc uccagcccua gaagccaauu aguccuccuc aaaaagcugu cacugucccc     5940

uaagaauugc ugccaggcuc ccacuggccu gacucagucu uugagagucu uaaggaggag     6000

gucucugaaa gguacacacc aagaacucuc cccagcacag cuguuuuuaa gacucuccac     6060

cagcgucauu ggcguguugg gaagaaaccc ucugccacag aggccagcuu cagccuuugc     6120

cuaacaccgc aagggcaaau ggaaagguaa acgggaagga gaugucuccc cagcaggcua     6180

uuugaggaca gucuucccug cagaagaucu caaccugggg uccacagagu ggaaauguua     6240

gaguagggag cuaggcaaac augagcagga caggugaggg cccccacagg aaugucaggc     6300

uaccaucagg ugauggucag gugguuguua aacugucucu guaaaauaau aauugguugc     6360

agccagcucc aagcaaggac agucucucaa uagauacaaa acacccugau cuggugauca     6420

gccgcuuccc gauaagaucu caggagcugg gcaagcagcc uggagcaugc gcaccaagag     6480

gcaaaauggc ggaauuuaac caguauauga ccuaccuucc ucugggaacg cacgacuggu     6540

aaggggaaaa augccucaag ugagcaugcg cgcaacuuca guaaucacac ugugcaugcg     6600

accccuucca agugcuggca ggucaccaca uacgcggaca gccugcugca agggaagaau     6660

caggggagau gagacguaaa ucccagaacu augccaaaua cauaaaaccc caaguuaagg     6720

gucaggcagg gcacuuagau cucucaaguu gccugccuga cccaagugua guguacuucc     6780

uuuuguuccu gcucuaaaac uuuuuaauaa acucucacuc cugcucuaaa a              6831


<210>  14
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  15
<211>  1350
<212>  RNA
<213>  Homo sapiens

<400>  15
guucguugca acaaauugau gagcaaugcu uuuuuauaau gccaacuuug uacaaaaaag       60

uuggcaugag cggugcuccg acggccgggg cagcccugau gcucugcgcc gccaccgccg      120

ugcuacugag cgcucagggc ggacccgugc aguccaaguc gccgcgcuuu gcguccuggg      180

acgagaugaa uguccuggcg cacggacucc ugcagcucgg ccaggggcug cgcgaacacg      240

cggagcgcac ccgcagucag cugagcgcgc uggagcggcg ccugagcgcg ugcggguccg      300

ccugucaggg aaccgagggg uccaccgacc ucccguuagc cccugagagc cggguggacc      360

cugagguccu ucacagccug cagacacaac ucaaggcuca gaacagcagg auccagcaac      420

ucuuccacaa gguggcccag cagcagcggc accuggagaa gcagcaccug cgaauucagc      480

aucugcaaag ccaguuuggc cuccuggacc acaagcaccu agaccaugag guggccaagc      540

cugcccgaag aaagaggcug cccgagaugg cccagccagu ugacccggcu cacaauguca      600

gccgccugca ccggcugccc agggauugcc aggagcuguu ccagguuggg gagaggcaga      660

guggacuauu ugaaauccag ccucaggggu cuccgccauu uuuggugaac ugcaagauga      720

ccucagaugg aggcuggaca guaauucaga ggcgccacga uggcucagug gacuucaacc      780

ggcccuggga agccuacaag gcgggguuug gggaucccca cggcgaguuc uggcuggguc      840

uggagaaggu gcauagcauc acgggggacc gcaacagccg ccuggccgug cagcugcggg      900

acugggaugg caacgccgag uugcugcagu ucuccgugca ccuggguggc gaggacacgg      960

ccuauagccu gcagcucacu gcacccgugg ccggccagcu gggcgccacc accgucccac     1020

ccagcggccu cuccguaccc uucuccacuu gggaccagga ucacgaccuc cgcagggaca     1080

agaacugcgc caagagccuc ucuggaggcu ggugguuugg caccugcagc cauuccaacc     1140

ucaacagcca guacuuccgc uccaucccac agcagcggca gaagcuuaag aagggaaucu     1200

ucuggaagac cuggcggggc cgcuacuacc cacugcaggc caccaccaug uugauccagc     1260

ccauggcagc agaggcagcc uccuacccaa cuuucuugua caaaguuggc auuauaagaa     1320

agcauugcuu aucaauuugu ugcaacgaac                                      1350


<210>  16
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  17
<211>  2615
<212>  RNA
<213>  Homo sapiens

<400>  17
ccuuuuuugg ccucgacggc ggcaacccag ccucccuccu aacgcccucc gccuuuggga       60

ccaaccaggg gagcucaagu uaguagcagc caaggagagg cgcugccuug ccaagacuaa      120

aaagggaggg gagaagagag gaaaaaagca agaauccccc accccucucc cgggcggagg      180

gggcgggaag agcgcguccu ggccaagccg aguagugucu uccacucggu gcgucucucu      240

aggagccgcg cgggaaggau gcugguccgc aggggcgcgc gcgagggccc aggaugccgc      300

ggggcuggac cgcgcuuugc uugcugaguu ugcugccuuc uggguucaug agucuugaca      360

acaacgguac ugcuacccca gaguuaccua cccagggaac auuuucaaau guuucuacaa      420

auguauccua ccaagaaacu acaacaccua guacccuugg aaguaccagc cugcacccug      480

ugucucaaca uggcaaugag gccacaacaa acaucacaga aacgacaguc aaauucacau      540

cuaccucugu gauaaccuca guuuauggaa acacaaacuc uucuguccag ucacagaccu      600

cuguaaucag cacaguguuc accaccccag ccaacguuuc aacuccagag acaaccuuga      660

agccuagccu gucaccugga aauguuucag accuuucaac cacuagcacu agccuugcaa      720

caucucccac uaaacccuau acaucaucuu cuccuauccu aagugacauc aaggcagaaa      780

ucaaauguuc aggcaucaga gaagugaaau ugacucaggg caucugccug gagcaaaaua      840

agaccuccag cugugcggag uuuaagaagg acaggggaga gggccuggcc cgagugcugu      900

guggggagga gcaggcugau gcugaugcug gggcccaggu augcucccug cuccuugccc      960

agucugaggu gaggccucag ugucuacugc uggucuuggc caacagaaca gaaauuucca     1020

gcaaacucca acuuaugaaa aagcaccaau cugaccugaa aaagcugggg auccuagauu     1080

ucacugagca agauguugca agccaccaga gcuauuccca aaagacccug auugcacugg     1140

ucaccucggg agcccugcug gcugucuugg gcaucacugg cuauuuccug augaaucgcc     1200

gcagcuggag ccccacagga gaaaggcugg gcgaagaccc uuauuacacg gaaaacggug     1260

gaggccaggg cuauagcuca ggaccuggga ccuccccuga ggcucaggga aaggccagug     1320

ugaaccgagg ggcucagaaa aacgggaccg gccaggccac cuccagaaac ggccauucag     1380

caagacaaca cgugguggcu gauaccgaau ugugacucgg cuaggugggg caaggcuggg     1440

caguguccga gagagcaccc cucucugcau cugaccacgu gcuaccccca ugcuggaggu     1500

gacaucucuu acgcccaacc cuuccccacu gcacacaccu cagaggcugu ucuuggggcc     1560

cuacaccuug aggagggggc agguaaacuc cuguccuuua cacauucggc ucccuggagc     1620

cagacucugg ucuucuuugg guaaacgugu gacgggggaa agccaagguc uggagaagcu     1680

cccaggaaca aucgauggcc uugcagcacu cacacaggac ccccuucccc uacccccucc     1740

ucucugccgc aauacaggaa cccccagggg aaagaugagc uuuucuaggc uacaauuuuc     1800

ucccaggaag cuuugauuuu uaccguuucu ucccuguauu uucuuucucu acuuugagga     1860

aaccaaagua accuuuugca ccugcucucu uguaaugaua uagccagaaa aacguguugc     1920

cuugaaccac uucccucauc ucuccuccaa gacacugugg acuuggucac cagcuccucc     1980

cuuguucucu aaguuccacu gagcuccaug ugcccccucu accauuugca gaguccugca     2040

caguuuucug gcuggagccu agaacaggcc ucccaaguuu uaggacaaac agcucaguuc     2100

uagucucucu ggggccacac agaaacucuu uuugggcucc uuuuucuccc ucuggaucaa     2160

aguaggcagg accaugggac caggucuugg agcugagccu cucaccugua cucuuccgaa     2220

aaauccucuu ccucugaggc uggauccuag ccuuauccuc ugaucuccau ggcuuccucc     2280

ucccuccugc cgacuccugg guugagcugu ugccucaguc ccccaacaga ugcuuuucug     2340

ucucugccuc ccucacccug agccccuucc uugcucugca cccccauaug gucauagccc     2400

agaucagcuc cuaacccuua ucaccagcug ccucuucugu gggugaccca gguccuuguu     2460

ugcuguugau uucuuuccag agggguugag cagggauccu gguuucaaug acgguuggaa     2520

auagaaauuu ccagagaaga gaguauuggg uagauauuuu uucugaauac aaagugaugu     2580

guuuaaauac ugcaauuaaa gugauacuga aacac                                2615


<210>  18
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  19
<211>  1197
<212>  RNA
<213>  Homo sapiens

<400>  19
gucucaauau uagagucuca acccccaaua aauauaggac uggagauguc ugaggcucau       60

ucugcccucg agcccaccgg gaacgaaaga gaagcucuau cuccccucca ggagcccagc      120

uaugaacucc uucuccacaa gcgccuucgg uccaguugcc uucucccugg ggcugcuccu      180

gguguugccu gcugccuucc cugccccagu acccccagga gaagauucca aagauguagc      240

cgccccacac agacagccac ucaccucuuc agaacgaauu gacaaacaaa uucgguacau      300

ccucgacggc aucucagccc ugagaaagga gacauguaac aagaguaaca ugugugaaag      360

cagcaaagag gcacuggcag aaaacaaccu gaaccuucca aagauggcug aaaaagaugg      420

augcuuccaa ucuggauuca augaggagac uugccuggug aaaaucauca cuggucuuuu      480

ggaguuugag guauaccuag aguaccucca gaacagauuu gagaguagug aggaacaagc      540

cagagcugug cagaugagua caaaaguccu gauccaguuc cugcagaaaa aggcaaagaa      600

ucuagaugca auaaccaccc cugacccaac cacaaaugcc agccugcuga cgaagcugca      660

ggcacagaac caguggcugc aggacaugac aacucaucuc auucugcgca gcuuuaagga      720

guuccugcag uccagccuga gggcucuucg gcaaauguag caugggcacc ucagauuguu      780

guuguuaaug ggcauuccuu cuucugguca gaaaccuguc cacugggcac agaacuuaug      840

uuguucucua uggagaacua aaaguaugag cguuaggaca cuauuuuaau uauuuuuaau      900

uuauuaauau uuaaauaugu gaagcugagu uaauuuaugu aagucauauu uauauuuuua      960

agaaguacca cuugaaacau uuuauguauu aguuuugaaa uaauaaugga aaguggcuau     1020

gcaguuugaa uauccuuugu uucagagcca gaucauuucu uggaaagugu aggcuuaccu     1080

caaauaaaug gcuaacuuau acauauuuuu aaagaaauau uuauauugua uuuauauaau     1140

guauaaaugg uuuuuauacc aauaaauggc auuuuaaaaa auucagcaaa aaaaaaa        1197


<210>  20
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  21
<211>  1184
<212>  RNA
<213>  Homo sapiens

<400>  21
cacagagccc gggccgcagg caccuccucg ccagcucuuc cgcuccucuc acagccgcca       60

gacccgccug cugagcccca uggcccgcgc ugcucucucc gccgccccca gcaauccccg      120

gcuccugcga guggcacugc ugcuccugcu ccugguagcc gcuggccggc gcgcagcagg      180

agcguccgug gccacugaac ugcgcugcca gugcuugcag acccugcagg gaauucaccc      240

caagaacauc caaaguguga acgugaaguc ccccggaccc cacugcgccc aaaccgaagu      300

cauagccaca cucaagaaug ggcggaaagc uugccucaau ccugcauccc ccauaguuaa      360

gaaaaucauc gaaaagaugc ugaacaguga caaauccaac ugaccagaag ggaggaggaa      420

gcucacuggu ggcuguuccu gaaggaggcc cugcccuuau aggaacagaa gaggaaagag      480

agacacagcu gcagaggcca ccuggauugu gccuaaugug uuugagcauc gcuuaggaga      540

agucuucuau uuauuuauuu auucauuagu uuugaagauu cuauguuaau auuuuaggug      600

uaaaauaauu aaggguauga uuaacucuac cugcacacug uccuauuaua uucauucuuu      660

uugaaauguc aaccccaagu uaguucaauc uggauucaua uuuaauuuga agguagaaug      720

uuuucaaaug uucuccaguc auuauguuaa uauuucugag gagccugcaa caugccagcc      780

acugugauag aggcuggcgg auccaagcaa auggccaaug agaucauugu gaaggcaggg      840

gaauguaugu gcacaucugu uuuguaacug uuuagaugaa ugucaguugu uauuuauuga      900

aaugauuuca cagugugugg ucaacauuuc ucauguugaa acuuuaagaa cuaaaauguu      960

cuaaauaucc cuuggacauu uuaugucuuu cuuguaaggc auacugccuu guuuaauggu     1020

aguuuuacag uguuucuggc uuagaacaaa ggggcuuaau uauugauguu uucauagaga     1080

auauaaaaau aaagcacuua uagaaaaaac ucguuugauu uuugggggga aacaagggcu     1140

accuuuacug gaaaaucugg ugauuuauaa aaaaaaaaaa aaaa                      1184


<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  23
<211>  1234
<212>  RNA
<213>  Homo sapiens

<400>  23
gagcuccggg aauuucccug gcccgggacu ccgggcuuuc cagccccaac caugcauaaa       60

agggguucgc cguucucgga gagccacaga gcccgggcca caggcagcuc cuugccagcu      120

cuccuccucg cacagccgcu cgaaccgccu gcugagcccc auggcccgcg ccacgcucuc      180

cgccgccccc agcaaucccc ggcuccugcg gguggcgcug cugcuccugc uccugguggc      240

cgccagccgg cgcgcagcag gagcgccccu ggccacugaa cugcgcugcc agugcuugca      300

gacccugcag ggaauucacc ucaagaacau ccaaagugug aaggugaagu cccccggacc      360

ccacugcgcc caaaccgaag ucauagccac acucaagaau gggcagaaag cuugucucaa      420

ccccgcaucg cccaugguua agaaaaucau cgaaaagaug cugaaaaaug gcaaauccaa      480

cugaccagaa ggaaggagga agcuuauugg uggcuguucc ugaaggaggc ccugcccuua      540

caggaacaga agaggaaaga gagacacagc ugcagaggcc accuggauug cgccuaaugu      600

guuugagcau cacuuaggag aagucuucua uuuauuuauu uauuuauuua uuuguuuguu      660

uuagaagauu cuauguuaau auuuuaugug uaaaauaagg uuaugauuga aucuacuugc      720

acacucuccc auuauauuua uuguuuauuu uaggucaaac ccaaguuagu ucaauccuga      780

uucauauuua auuugaagau agaagguuug cagauauucu cuagucauuu guuaauauuu      840

cuucgugaug acauaucaca ugucagccac ugugauagag gcugaggaau ccaagaaaau      900

ggccagugag aucaauguga cggcagggaa auguaugugu gucuauuuug uaacuguaaa      960

gaugaauguc aguuguuauu uauugaaaug auuucacagu guguggucaa cauuucucau     1020

guugaagcuu uaagaacuaa aauguucuaa auaucccuug gacauuuuau gucuuucuug     1080

uaaggcauac ugccuuguuu aauguuaauu augcaguguu ucccucugug uuagagcaga     1140

gagguuucga uauuuauuga uguuuucaca aagaacagga aaauaaaaua uuuaaaaaua     1200

uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 1234


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  25
<211>  1166
<212>  RNA
<213>  Homo sapiens

<400>  25
gcuccgggaa uuucccuggc ccggccgcuc cgggcuuucc agucucaacc augcauaaaa       60

aggguucgcc gaucuugggg agccacacag cccgggucgc aggcaccucc ccgccagcuc      120

ucccgcuucu cgcacagcuu cccgacgcgu cugcugagcc ccauggccca cgccacgcuc      180

uccgccgccc ccagcaaucc ccggcuccug cggguggcgc ugcugcuccu gcuccuggug      240

gccgccagcc ggcgcgcagc aggagcgucc guggucacug aacugcgcug ccagugcuug      300

cagacacugc agggaauuca ccucaagaac auccaaagug ugaauguaag gucccccgga      360

ccccacugcg cccaaaccga agucauagcc acacucaaga augggaagaa agcuugucuc      420

aaccccgcau cccccauggu ucagaaaauc aucgaaaaga uacugaacaa ggggagcacc      480

aacugacagg agagaaguaa gaagcuuauc agcguaucau ugacacuucc ugcagggugg      540

ucccugcccu uaccagagcu gaaaaugaaa aagagaacag cagcuuucua gggacagcug      600

gaaaggacuu aauguguuug acuauuucuu acgaggguuc uacuuauuua uguauuuauu      660

uuugaaagcu uguauuuuaa uauuuuacau gcuguuauuu aaagauguga guguguuuca      720

ucaaacauag cucaguccug auuauuuaau uggaauauga uggguuuuaa augugucauu      780

aaacuaauau uuagugggag accauaaugu gucagccacc uugauaaaug acaggguggg      840

gaacuggagg guggggggau ugaaaugcaa gcaauuagug gaucacuguu aggguaaggg      900

aauguaugua cacaucuauu uuuuauacuu uuuuuuuaaa aaaagaaugu caguuguuau      960

uuauucaaau uaucucacau uauguguuca acauuuuuau gcugaaguuu cccuuagaca     1020

uuuuaugucu ugcuuguagg gcauaaugcc uuguuuaaug uccauucugc agcguuucuc     1080

uuucccuugg aaaagagaau uuaucauuac uguuacauuu guacaaauga caugauaaua     1140

aaaguuuuau gaaaaaaaaa aaaaaa                                          1166


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  27
<211>  1718
<212>  RNA
<213>  Homo sapiens

<400>  27
gagggugcau aaguucucua guagggugau gauauaaaaa gccaccggag cacuccauaa       60

ggcacaaacu uucagagaca gcagagcaca caagcuucua ggacaagagc caggaagaaa      120

ccaccggaag gaaccaucuc acugugugua aacaugacuu ccaagcuggc cguggcucuc      180

uuggcagccu uccugauuuc ugcagcucug ugugaaggug caguuuugcc aaggagugcu      240

aaagaacuua gaugucagug cauaaagaca uacuccaaac cuuuccaccc caaauuuauc      300

aaagaacuga gagugauuga gaguggacca cacugcgcca acacagaaau uauuguaaag      360

cuuucugaug gaagagagcu cugucuggac cccaaggaaa acugggugca gaggguugug      420

gagaaguuuu ugaagagggc ugagaauuca uaaaaaaauu cauucucugu gguauccaag      480

aaucagugaa gaugccagug aaacuucaag caaaucuacu ucaacacuuc auguauugug      540

ugggucuguu guaggguugc cagaugcaau acaagauucc ugguuaaauu ugaauuucag      600

uaaacaauga auaguuuuuc auuguaccau gaaauaucca gaacauacuu auauguaaag      660

uauuauuuau uugaaucuac aaaaaacaac aaauaauuuu uaaauauaag gauuuuccua      720

gauauugcac gggagaauau acaaauagca aaauugaggc caagggccaa gagaauaucc      780

gaacuuuaau uucaggaauu gaauggguuu gcuagaaugu gauauuugaa gcaucacaua      840

aaaaugaugg gacaauaaau uuugccauaa agucaaauuu agcuggaaau ccuggauuuu      900

uuucuguuaa aucuggcaac ccuagucugc uagccaggau ccacaagucc uuguuccacu      960

gugccuuggu uucuccuuua uuucuaagug gaaaaaguau uagccaccau cuuaccucac     1020

agugauguug ugaggacaug uggaagcacu uuaaguuuuu ucaucauaac auaaauuauu     1080

uucaagugua acuuauuaac cuauuuauua uuuauguauu uauuuaagca ucaaauauuu     1140

gugcaagaau uuggaaaaau agaagaugaa ucauugauug aauaguuaua aagauguuau     1200

aguaaauuua uuuuauuuua gauauuaaau gauguuuuau uagauaaauu ucaaucaggg     1260

uuuuuagauu aaacaaacaa acaauugggu acccaguuaa auuuucauuu cagauaaaca     1320

acaaauaauu uuuuaguaua aguacauuau uguuuaucug aaauuuuaau ugaacuaaca     1380

auccuaguuu gauacuccca gucuugucau ugccagcugu guugguagug cuguguugaa     1440

uuacggaaua augaguuaga acuauuaaaa cagccaaaac uccacaguca auauuaguaa     1500

uuucuugcug guugaaacuu guuuauuaug uacaaauaga uucuuauaau auuauuuaaa     1560

ugacugcauu uuuaaauaca aggcuuuaua uuuuuaacuu uaagauguuu uuaugugcuc     1620

uccaaauuuu uuuuacuguu ucugauugua uggaaauaua aaaguaaaua ugaaacauuu     1680

aaaauauaau uuguugucaa aguaaaaaaa aaaaaaaa                             1718


<210>  28
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  29
<211>  4507
<212>  RNA
<213>  Homo sapiens

<400>  29
gaccaauugu cauacgacuu gcagugagcg ucaggagcac guccaggaac uccucagcag       60

cgccuccuuc agcuccacag ccagacgccc ucagacagca aagccuaccc ccgcgccgcg      120

cccugcccgc cgcugcgaug cucgcccgcg cccugcugcu gugcgcgguc cuggcgcuca      180

gccauacagc aaauccuugc uguucccacc caugucaaaa ccgaggugua uguaugagug      240

ugggauuuga ccaguauaag ugcgauugua cccggacagg auucuaugga gaaaacugcu      300

caacaccgga auuuuugaca agaauaaaau uauuucugaa acccacucca aacacagugc      360

acuacauacu uacccacuuc aagggauuuu ggaacguugu gaauaacauu cccuuccuuc      420

gaaaugcaau uaugaguuau guguugacau ccagaucaca uuugauugac aguccaccaa      480

cuuacaaugc ugacuauggc uacaaaagcu gggaagccuu cucuaaccuc uccuauuaua      540

cuagagcccu uccuccugug ccugaugauu gcccgacucc cuuggguguc aaagguaaaa      600

agcagcuucc ugauucaaau gagauugugg aaaaauugcu ucuaagaaga aaguucaucc      660

cugaucccca gggcucaaac augauguuug cauucuuugc ccagcacuuc acgcaucagu      720

uuuucaagac agaucauaag cgagggccag cuuucaccaa cgggcugggc cauggggugg      780

acuuaaauca uauuuacggu gaaacucugg cuagacagcg uaaacugcgc cuuuucaagg      840

auggaaaaau gaaauaucag auaauugaug gagagaugua uccucccaca gucaaagaua      900

cucaggcaga gaugaucuac ccuccucaag ucccugagca ucuacgguuu gcuguggggc      960

aggaggucuu uggucuggug ccuggucuga ugauguaugc cacaaucugg cugcgggaac     1020

acaacagagu augcgaugug cuuaaacagg agcauccuga auggggugau gagcaguugu     1080

uccagacaag caggcuaaua cugauaggag agacuauuaa gauugugauu gaagauuaug     1140

ugcaacacuu gaguggcuau cacuucaaac ugaaauuuga cccagaacua cuuuucaaca     1200

aacaauucca guaccaaaau cguauugcug cugaauuuaa cacccucuau cacuggcauc     1260

cccuucugcc ugacaccuuu caaauucaug accagaaaua caacuaucaa caguuuaucu     1320

acaacaacuc uauauugcug gaacauggaa uuacccaguu uguugaauca uucaccaggc     1380

aaauugcugg caggguugcu ggugguagga auguuccacc cgcaguacag aaaguaucac     1440

aggcuuccau ugaccagagc aggcagauga aauaccaguc uuuuaaugag uaccgcaaac     1500

gcuuuaugcu gaagcccuau gaaucauuug aagaacuuac aggagaaaag gaaaugucug     1560

cagaguugga agcacucuau ggugacaucg augcugugga gcuguauccu gcccuucugg     1620

uagaaaagcc ucggccagau gccaucuuug gugaaaccau gguagaaguu ggagcaccau     1680

ucuccuugaa aggacuuaug gguaauguua uauguucucc ugccuacugg aagccaagca     1740

cuuuuggugg agaagugggu uuucaaauca ucaacacugc cucaauucag ucucucaucu     1800

gcaauaacgu gaagggcugu cccuuuacuu cauucagugu uccagaucca gagcucauua     1860

aaacagucac caucaaugca aguucuuccc gcuccggacu agaugauauc aaucccacag     1920

uacuacuaaa agaacguucg acugaacugu agaagucuaa ugaucauauu uauuuauuua     1980

uaugaaccau gucuauuaau uuaauuauuu aauaauauuu auauuaaacu ccuuauguua     2040

cuuaacaucu ucuguaacag aagucaguac uccuguugcg gagaaaggag ucauacuugu     2100

gaagacuuuu augucacuac ucuaaagauu uugcuguugc uguuaaguuu ggaaaacagu     2160

uuuuauucug uuuuauaaac cagagagaaa ugaguuuuga cgucuuuuua cuugaauuuc     2220

aacuuauauu auaagaacga aaguaaagau guuugaauac uuaaacacug ucacaagaug     2280

gcaaaaugcu gaaaguuuuu acacugucga uguuuccaau gcaucuucca ugaugcauua     2340

gaaguaacua auguuugaaa uuuuaaagua cuuuugguua uuuuucuguc aucaaacaaa     2400

aacagguauc agugcauuau uaaaugaaua uuuaaauuag acauuaccag uaauuucaug     2460

ucuacuuuuu aaaaucagca augaaacaau aauuugaaau uucuaaauuc auaggguaga     2520

aucaccugua aaagcuuguu ugauuucuua aaguuauuaa acuuguacau auaccaaaaa     2580

gaagcugucu uggauuuaaa ucuguaaaau caguagaaau uuuacuacaa uugcuuguua     2640

aaauauuuua uaagugaugu uccuuuuuca ccaagaguau aaaccuuuuu agugugacug     2700

uuaaaacuuc cuuuuaaauc aaaaugccaa auuuauuaag gugguggagc cacugcagug     2760

uuaucuuaaa auaagaauau uuuguugaga uauuccagaa uuuguuuaua uggcugguaa     2820

cauguaaaau cuauaucagc aaaagggucu accuuuaaaa uaagcaauaa caaagaagaa     2880

aaccaaauua uuguucaaau uuagguuuaa acuuuugaag caaacuuuuu uuuauccuug     2940

ugcacugcag gccugguacu cagauuuugc uaugagguua augaaguacc aagcugugcu     3000

ugaauaauga uauguuuucu cagauuuucu guuguacagu uuaauuuagc aguccauauc     3060

acauugcaaa aguagcaaug accucauaaa auaccucuuc aaaaugcuua aauucauuuc     3120

acacauuaau uuuaucucag ucuugaagcc aauucaguag gugcauugga aucaagccug     3180

gcuaccugca ugcuguuccu uuucuuuucu ucuuuuagcc auuuugcuaa gagacacagu     3240

cuucucauca cuucguuucu ccuauuuugu uuuacuaguu uuaagaucag aguucacuuu     3300

cuuuggacuc ugccuauauu uucuuaccug aacuuuugca aguuuucagg uaaaccucag     3360

cucaggacug cuauuuagcu ccucuuaaga agauuaaaag agaaaaaaaa aggcccuuuu     3420

aaaaauagua uacacuuauu uuaagugaaa agcagagaau uuuauuuaua gcuaauuuua     3480

gcuaucugua accaagaugg augcaaagag gcuagugccu cagagagaac uguacggggu     3540

uugugacugg aaaaaguuac guucccauuc uaauuaaugc ccuuucuuau uuaaaaacaa     3600

aaccaaauga uaucuaagua guucucagca auaauaauaa ugacgauaau acuucuuuuc     3660

cacaucucau ugucacugac auuuaauggu acuguauauu acuuaauuua uugaagauua     3720

uuauuuaugu cuuauuagga cacuaugguu auaaacugug uuuaagccua caaucauuga     3780

uuuuuuuuug uuaugucaca aucaguauau uuucuuuggg guuaccucuc ugaauauuau     3840

guaaacaauc caaagaaaug auuguauuaa gauuugugaa uaaauuuuua gaaaucugau     3900

uggcauauug agauauuuaa gguugaaugu uuguccuuag gauaggccua ugugcuagcc     3960

cacaaagaau auugucucau uagccugaau gugccauaag acugaccuuu uaaaauguuu     4020

ugagggaucu guggaugcuu cguuaauuug uucagccaca auuuauugag aaaauauucu     4080

gugucaagca cuguggguuu uaauauuuuu aaaucaaacg cugauuacag auaauaguau     4140

uuauauaaau aauugaaaaa aauuuucuuu ugggaagagg gagaaaauga aauaaauauc     4200

auuaaagaua acucaggaga aucuucuuua caauuuuacg uuuagaaugu uuaagguuaa     4260

gaaagaaaua gucaauaugc uuguauaaaa cacuguucac uguuuuuuuu aaaaaaaaaa     4320

cuugauuugu uauuaacauu gaucugcuga caaaaccugg gaauuugggu uguguaugcg     4380

aauguuucag ugccucagac aaauguguau uuaacuuaug uaaaagauaa gucuggaaau     4440

aaaugucugu uuauuuuugu acuauuuaaa aauugacaga ucuuuucuga agaaaaaaaa     4500

aaaaaaa                                                               4507


<210>  30
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  31
<211>  1204
<212>  RNA
<213>  Homo sapiens

<400>  31
ggggugcaaa gaagagacag cagcgcccag cuuggaggug cuaacuccag aggccagcau       60

cagcaacugg gcacagaaag gagccgccug ggcagggacc auggcacggc cacaucccug      120

guggcugugc guucugggga cccugguggg gcucucagcu acuccagccc ccaagagcug      180

cccagagagg cacuacuggg cucagggaaa gcugugcugc cagaugugug agccaggaac      240

auuccucgug aaggacugug accagcauag aaaggcugcu cagugugauc cuugcauacc      300

gggggucucc uucucuccug accaccacac ccggccccac ugugagagcu gucggcacug      360

uaacucuggu cuucucguuc gcaacugcac caucacugcc aaugcugagu gugccugucg      420

caauggcugg cagugcaggg acaaggagug caccgagugu gauccucuuc caaacccuuc      480

gcugaccgcu cggucgucuc aggcccugag cccacacccu cagcccaccc acuuaccuua      540

ugucagugag augcuggagg ccaggacagc ugggcacaug cagacucugg cugacuucag      600

gcagcugccu gcccggacuc ucucuaccca cuggccaccc caaagauccc ugugcagcuc      660

cgauuuuauu cgcauccuug ugaucuucuc uggaauguuc cuuguuuuca cccuggccgg      720

ggcccuguuc cuccaucaac gaaggaaaua uagaucaaac aaaggagaaa guccugugga      780

gccugcagag ccuugucguu acagcugccc cagggaggag gagggcagca ccauccccau      840

ccaggaggau uaccgaaaac cggagccugc cugcuccccc ugagccagca ccugcgguag      900

cugcacuaca gcccuggccu ccacccccac cccgccgacc auccaaggga gagugagacc      960

uggcagccac aacugcaguc ccauccucuu gucagggccc uuuccugugu acacgugaca     1020

gagugccuuu ucgagacugg cagggacgag gacaaauaug gaugaggugg agagugggaa     1080

gcaggagccc agccagcugc gccugcgcug caggagggcg ggggcucugg uuguaaaaca     1140

cacuuccugc ugcgaaagac ccacaugcua caagacgggc aaaauaaagu gacagaugac     1200

cacc                                                                  1204


<210>  32
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  33
<211>  2397
<212>  RNA
<213>  Homo sapiens

<400>  33
gcacacacuc aucgaaaaaa auuuggauua uuagaagaga gaggucugcg gcuuccacac       60

cguacagcgu gguuuuucuu cucgguauaa aagcaaaguu guuuuugaua cgugacaguu      120

ucccacaagc caggcugauc cuuuucuguc aguccacuuc accaagccug cccuuggaca      180

aggacccgau gcccaacccc aggccuggca agcccucggc cccuuccuug gcccuuggcc      240

cauccccagg agccucgccc agcuggaggg cugcacccaa agccucagac cugcuggggg      300

cccggggccc agggggaacc uuccagggcc gagaucuucg aggcggggcc caugccuccu      360

cuucuuccuu gaaccccaug ccaccaucgc agcugcagcu gcccacacug ccccuaguca      420

ugguggcacc cuccggggca cggcugggcc ccuugcccca cuuacaggca cuccuccagg      480

acaggccaca uuucaugcac cagcucucaa cgguggaugc ccacgcccgg accccugugc      540

ugcaggugca cccccuggag agcccagcca ugaucagccu cacaccaccc accaccgcca      600

cuggggucuu cucccucaag gcccggccug gccucccacc ugggaucaac guggccagcc      660

uggaaugggu guccagggag ccggcacugc ucugcaccuu cccaaauccc agugcaccca      720

ggaaggacag cacccuuucg gcugugcccc agagcuccua cccacugcug gcaaauggug      780

ucugcaagug gcccggaugu gagaaggucu ucgaagagcc agaggacuuc cucaagcacu      840

gccaggcgga ccaucuucug gaugagaagg gcagggcaca augucuccuc cagagagaga      900

ugguacaguc ucuggagcag cagcuggugc uggagaagga gaagcugagu gccaugcagg      960

cccaccuggc ugggaaaaug gcacugacca aggcuucauc uguggcauca uccgacaagg     1020

gcuccugcug caucguagcu gcuggcagcc aaggcccugu cgucccagcc uggucuggcc     1080

cccgggaggc cccugacagc cuguuugcug uccggaggca ccuguggggu agccauggaa     1140

acagcacauu cccagaguuc cuccacaaca uggacuacuu caaguuccac aacaugcgac     1200

ccccuuucac cuacgccacg cucauccgcu gggccauccu ggaggcucca gagaagcagc     1260

ggacacucaa ugagaucuac cacugguuca cacgcauguu ugccuucuuc agaaaccauc     1320

cugccaccug gaagaacgcc auccgccaca accugagucu gcacaagugc uuugugcggg     1380

uggagagcga gaagggggcu guguggaccg uggaugagcu ggaguuccgc aagaaacgga     1440

gccagaggcc cagcaggugu uccaacccua caccuggccc cugaccucaa gaucaaggaa     1500

aggaggaugg acgaacaggg gccaaacugg ugggaggcag aggugguggg ggcagggaug     1560

auaggcccug gaugugccca cagggaccaa gaagugaggu uuccacuguc uugccugcca     1620

gggccccugu ucccccgcug gcagccaccc ccucccccau cauauccuuu gccccaaggc     1680

ugcucagagg ggccccgguc cuggccccag cccccaccuc cgccccagac acacccccca     1740

gucgagcccu gcagccaaac agagccuuca caaccagcca cacagagccu gccucagcug     1800

cucgcacaga uuacuucagg gcuggaaaag ucacacagac acacaaaaug ucacaauccu     1860

gucccucacu caacacaaac cccaaaacac agagagccug ccucaguaca cucaaacaac     1920

cucaaagcug caucaucaca caaucacaca caagcacagc ccugacaacc cacacacccc     1980

aaggcacgca cccacagcca gccucagggc ccacaggggc acugucaaca caggggugug     2040

cccagaggcc uacacagaag cagcgucagu acccucagga ucugaggucc caacacgugc     2100

ucgcucacac acacggccug uuagaauuca ccuguguauc ucacgcauau gcacacgcac     2160

agccccccag ugggucucuu gagucccgug cagacacaca cagccacaca cacugccuug     2220

ccaaaaauac cccgugucuc cccugccacu caccucacuc ccauucccug agcccugauc     2280

caugccucag cuuagacugc agaggaacua cucauuuauu ugggauccaa ggcccccaac     2340

ccacaguacc guccccaaua aacugcagcc gagcucccca caaaaaaaaa aaaaaaa        2397


<210>  34
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  35
<211>  2115
<212>  RNA
<213>  Homo sapiens

<400>  35
aguuucccuu ccgcucaccu ccgccugagc aguggagaag gcggcacucu gguggggcug       60

cuccaggcau gcagauccca caggcgcccu ggccagucgu cugggcggug cuacaacugg      120

gcuggcggcc aggaugguuc uuagacuccc cagacaggcc cuggaacccc cccaccuucu      180

ccccagcccu gcucguggug accgaagggg acaacgccac cuucaccugc agcuucucca      240

acacaucgga gagcuucgug cuaaacuggu accgcaugag ccccagcaac cagacggaca      300

agcuggccgc cuuccccgag gaccgcagcc agcccggcca ggacugccgc uuccguguca      360

cacaacugcc caacgggcgu gacuuccaca ugagcguggu cagggcccgg cgcaaugaca      420

gcggcaccua ccucuguggg gccaucuccc uggcccccaa ggcgcagauc aaagagagcc      480

ugcgggcaga gcucagggug acagagagaa gggcagaagu gcccacagcc caccccagcc      540

ccucacccag gccagccggc caguuccaaa cccugguggu uggugucgug ggcggccugc      600

ugggcagccu ggugcugcua gucugggucc uggccgucau cugcucccgg gccgcacgag      660

ggacaauagg agccaggcgc accggccagc cccugaagga ggaccccuca gccgugccug      720

uguucucugu ggacuauggg gagcuggauu uccaguggcg agagaagacc ccggagcccc      780

ccgugcccug ugucccugag cagacggagu augccaccau ugucuuuccu agcggaaugg      840

gcaccucauc ccccgcccgc aggggcucag cugacggccc ucggagugcc cagccacuga      900

ggccugagga uggacacugc ucuuggcccc ucugaccggc uuccuuggcc accaguguuc      960

ugcagacccu ccaccaugag cccgggucag cgcauuuccu caggagaagc aggcagggug     1020

caggccauug caggccgucc aggggcugag cugccugggg gcgaccgggg cuccagccug     1080

caccugcacc aggcacagcc ccaccacagg acucaugucu caaugcccac agugagccca     1140

ggcagcaggu gucaccgucc ccuacaggga gggccagaug cagucacugc uucagguccu     1200

gccagcacag agcugccugc guccagcucc cugaaucucu gcugcugcug cugcugcugc     1260

ugcugcugcc ugcggcccgg ggcugaaggc gccguggccc ugccugacgc cccggagccu     1320

ccugccugaa cuugggggcu gguuggagau ggccuuggag cagccaaggu gccccuggca     1380

guggcauccc gaaacgcccu ggacgcaggg cccaagacug ggcacaggag ugggagguac     1440

auggggcugg ggacucccca ggaguuaucu gcucccugca ggccuagaga aguuucaggg     1500

aaggucagaa gagcuccugg cugugguggg cagggcagga aaccccucca ccuuuacaca     1560

ugcccaggca gcaccucagg cccuuugugg ggcagggaag cugaggcagu aagcgggcag     1620

gcagagcugg aggccuuuca ggcccagcca gcacucuggc cuccugccgc cgcauuccac     1680

cccagccccu cacaccacuc gggagaggga cauccuacgg ucccaagguc aggagggcag     1740

ggcugggguu gacucaggcc ccucccagcu guggccaccu ggguguuggg agggcagaag     1800

ugcaggcacc uagggccccc caugugccca cccugggagc ucuccuugga acccauuccu     1860

gaaauuauuu aaagggguug gccgggcucc caccagggcc ugggugggaa gguacaggcg     1920

uucccccggg gccuaguacc cccgccgugg ccuauccacu ccucacaucc acacacugca     1980

cccccacucc uggggcaggg ccaccagcau ccaggcggcc agcaggcacc ugaguggcug     2040

ggacaaggga ucccccuucc cugugguucu auuauauuau aauuauaauu aaauaugaga     2100

gcaugcuaag gaaaa                                                      2115


<210>  36
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  37
<211>  2033
<212>  RNA
<213>  Homo sapiens

<400>  37
cuucugugug ugcacaugug uaauacauau cugggaucaa agcuaucuau auaaaguccu       60

ugauucugug uggguucaaa cacauuucaa agcuucagga uccugaaagg uuuugcucua      120

cuuccugaag accugaacac cgcucccaua aagccauggc uugccuugga uuucagcggc      180

acaaggcuca gcugaaccug gcuaccagga ccuggcccug cacucuccug uuuuuucuuc      240

ucuucauccc ugucuucugc aaagcaaugc acguggccca gccugcugug guacuggcca      300

gcagccgagg caucgccagc uuugugugug aguaugcauc uccaggcaaa gccacugagg      360

uccgggugac agugcuucgg caggcugaca gccaggugac ugaagucugu gcggcaaccu      420

acaugauggg gaaugaguug accuuccuag augauuccau cugcacgggc accuccagug      480

gaaaucaagu gaaccucacu auccaaggac ugagggccau ggacacggga cucuacaucu      540

gcaaggugga gcucauguac ccaccgccau acuaccuggg cauaggcaac ggaacccaga      600

uuuauguaau ugauccagaa ccgugcccag auucugacuu ccuccucugg auccuugcag      660

caguuaguuc gggguuguuu uuuuauagcu uucuccucac agcuguuucu uugagcaaaa      720

ugcuaaagaa aagaagcccu cuuacaacag gggucuaugu gaaaaugccc ccaacagagc      780

cagaauguga aaagcaauuu cagccuuauu uuauucccau caauugagaa accauuauga      840

agaagagagu ccauauuuca auuuccaaga gcugaggcaa uucuaacuuu uuugcuaucc      900

agcuauuuuu auuuguuugu gcauuugggg ggaauucauc ucucuuuaau auaaaguugg      960

augcggaacc caaauuacgu guacuacaau uuaaagcaaa ggaguagaaa gacagagcug     1020

ggauguuucu gucacaucag cuccacuuuc agugaaagca ucacuuggga uuaauauggg     1080

gaugcagcau uaugaugugg gucaaggaau uaaguuaggg aauggcacag cccaaagaag     1140

gaaaaggcag ggagcgaggg agaagacuau auuguacaca ccuuauauuu acguaugaga     1200

cguuuauagc cgaaaugauc uuuucaaguu aaauuuuaug ccuuuuauuu cuuaaacaaa     1260

uguaugauua caucaaggcu ucaaaaauac ucacauggcu auguuuuagc cagugaugcu     1320

aaagguugua uugcauauau acauauauau auauauauau auauauauau auauauauau     1380

auauauauau auauauauuu uaauuugaua guauugugca uagagccacg uauguuuuug     1440

uguauuuguu aaugguuuga auauaaacac uauauggcag ugucuuucca ccuugggucc     1500

cagggaaguu uuguggagga gcucaggaca cuaauacacc agguagaaca caaggucauu     1560

ugcuaacuag cuuggaaacu ggaugagguc auagcagugc uugauugcgu ggaauugugc     1620

ugaguuggug uugacaugug cuuuggggcu uuuacaccag uuccuuucaa ugguuugcaa     1680

ggaagccaca gcugguggua ucugaguuga cuugacagaa cacugucuug aagacaaugg     1740

cuuacuccag gagacccaca gguaugaccu ucuaggaagc uccaguucga ugggcccaau     1800

ucuuacaaac augugguuaa ugccauggac agaagaaggc agcagguggc agaauggggu     1860

gcaugaaggu uucugaaaau uaacacugcu uguguuuuua acucaauauu uuccaugaaa     1920

augcaacaac auguauaaua uuuuuaauua aauaaaaauc uguggugguc guuuuaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            2033


<210>  38
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  39
<211>  2978
<212>  RNA
<213>  Homo sapiens

<400>  39
cguccuaucu gcagucggcu acuuucagug gcagaagagg ccacaucugc uuccuguagg       60

cccucugggc agaagcaugc gcuggugucu ccuccugauc ugggcccagg ggcugaggca      120

ggcuccccuc gccucaggaa ugaugacagg cacaauagaa acaacgggga acauuucugc      180

agagaaaggu ggcucuauca ucuuacaaug ucaccucucc uccaccacgg cacaagugac      240

ccaggucaac ugggagcagc aggaccagcu ucuggccauu uguaaugcug acuuggggug      300

gcacaucucc ccauccuuca aggaucgagu ggccccaggu cccggccugg gccucacccu      360

ccagucgcug accgugaacg auacagggga guacuucugc aucuaucaca ccuacccuga      420

ugggacguac acugggagaa ucuuccugga gguccuagaa agcucagugg cugagcacgg      480

ugccagguuc cagauuccau ugcuuggagc cauggccgcg acgcuggugg ucaucugcac      540

agcagucauc gugguggucg cguugacuag aaagaagaaa gcccucagaa uccauucugu      600

ggaaggugac cucaggagaa aaucagcugg acaggaggaa uggagcccca gugcucccuc      660

acccccagga agcugugucc aggcagaagc ugcaccugcu gggcucugug gagagcagcg      720

gggagaggac ugugccgagc ugcaugacua cuucaauguc cugaguuaca gaagccuggg      780

uaacugcagc uucuucacag agacugguua gcaaccagag gcaucuucug gaagauacac      840

uuuugucuuu gcuauuauag augaauauau aagcagcugu acucuccauc agugcugcgu      900

gugugugugu guguguaugu gugugugugu ucaguugagu gaauaaaugu cauccucuuc      960

uccaucuuca uuuccuuggc cuuuucguuc uauuccauuu ugcauuaugg caggccuagg     1020

gugaguaacg uggaucuuga ucauaaaugc aaaauuaaaa aauaucuuga ccugguuuua     1080

aaucuggcag uuugagcaga uccuaugucu cugagagaca cauuccucau aauggccagc     1140

auuuugggcu acaagguuuu gugguugaug augaggaugg caugacugca gagccauccu     1200

caucucauuu uuucacguca uuuucaguaa cuuucacuca uucaaaggca gguuauaagu     1260

aaguccuggu agcagccucu auggggagau uugagaguga cuaaaucuug guaucugccc     1320

ucaagaacuu acaguuaaau ggggagacaa uguugucaug aaaagguauu auaguaagga     1380

gagaaggaga cauacacagg ccuucaggaa gagacgacag uuugggguga gguaguuggc     1440

auaggcuuau cugugaugaa guggccuggg agcaccaagg ggauguugag gcuagucugg     1500

gaggagcagg aguuuugucu agggaacuug uaggaaauuc uuggagcuga aagucccaca     1560

aagaaggccc uggcaccaag ggagucagca aacuucagau uuuauucucu gggcaggcau     1620

uucaaguuuc cuuuugcugu gacauacuca uccauuagac agccugauac aggccuguag     1680

ccucuuccgg ccgugugugc uggggaagcc ccaggaaacg cacaugccca cacagggagc     1740

caagucguag cauuugggcc uugaucuacc uuuucugcau caauacacuc uugagccuuu     1800

gaaaaaagaa cguuucccac uaaaaagaaa auguggauuu uuaaaauagg gacucuuccu     1860

aggggaaaaa ggggggcugg gagugauaga ggguuuaaaa aauaaacacc uucaaacuaa     1920

cuucuucgaa cccuuuuauu cacucccuga cgacuuugug cugggguugg gguaacugaa     1980

ccgcuuauuu cuguuuaauu gcauucaggc uggaucuuag aagacuuuua uccuuccacc     2040

aucucucuca gaggaaugag cggggagguu ggauuuacug gugacugauu uucuuucaug     2100

ggccaaggaa cugaaagaga augugaagca agguuguguc uugcgcaugg uuaaaaauaa     2160

agcauugucc ugcuuccuaa gacuuagacu gggguugaca auuguuuuag caacaagaca     2220

auucaacuau uucuccuagg auuuuuauua uuauuauuuu uucacuuuuc uaccaaaugg     2280

guuacauagg aagaaugaac ugaaaucugu ccagagcucc aaguccuuug gaagaaagau     2340

uagaugaacg uaaaaauguu guuguuugcu guggcaguuu acagcauuuu ucuugcaaaa     2400

uuagugcaaa ucuguuggaa auagaacaca auucacaaau uggaagugaa cuaaaaugua     2460

augacgaaaa gggaguagug uuuugauuug gaggaggugu auauucggca gagguuggac     2520

ugagaguugg guguuauuua acauaauuau gguaauuggg aaacauuuau aaacacuauu     2580

gggaugguga uaaaauacaa aagggccuau agauguuaga aaugggucag guuacugaaa     2640

ugggauucaa uuugaaaaaa auuuuuuuaa auagaacuca cugaacuaga uucuccucug     2700

agaaccagag aagaccauuu cauaguugga uuccuggaga caugcgcuau ccaccacgua     2760

gccacuuucc acauguggcc aucaaccacu uaagaugggg uuaguuuaaa ucaagaugug     2820

cuguuauaau ugguauaagc auaaaaucac acuagauucu ggagauuuaa uaugaauaau     2880

aagaauacua uuucaguagu uuugguauau ugugugucaa aaaugauaau auuuuggaug     2940

uauuggguga aauaaaauau uaacauuaaa aaaaaaaa                             2978


<210>  40
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  41
<211>  1944
<212>  RNA
<213>  Homo sapiens

<400>  41
aauuucucac ugccccugug auaaacugug gucacuggcu guggcagcaa cuauuauaag       60

augcucugaa aacucuucag acacugaggg gcaccagagg agcagacuac aagaauggca      120

cacgcuaugg aaaacuccug gacaaucagu aaagaguacc auauugauga agaagugggc      180

uuugcucugc caaauccaca ggaaaaucua ccugauuuuu auaaugacug gauguucauu      240

gcuaaacauc ugccugaucu cauagagucu ggccagcuuc gagaaagagu ugagaaguua      300

aacaugcuca gcauugauca ucucacagac cacaagucac agcgccuugc acgucuaguu      360

cugggaugca ucaccauggc auaugugugg ggcaaagguc auggagaugu ccguaagguc      420

uugccaagaa auauugcugu uccuuacugc caacucucca agaaacugga acugccuccu      480

auuuugguuu augcagacug ugucuuggca aacuggaaga aaaaggaucc uaauaagccc      540

cugacuuaug agaacaugga cguuuuguuc ucauuucgug auggagacug caguaaagga      600

uucuuccugg ucucucuauu gguggaaaua gcagcugcuu cugcaaucaa aguaauuccu      660

acuguauuca aggcaaugca aaugcaagaa cgggacacuu ugcuaaaggc gcuguuggaa      720

auagcuucuu gcuuggagaa agcccuucaa guguuucacc aaauccacga ucaugugaac      780

ccaaaagcau uuuucagugu ucuucgcaua uauuugucug gcuggaaagg caacccccag      840

cuaucagacg gucuggugua ugaaggguuc ugggaagacc caaaggaguu ugcagggggc      900

agugcaggcc aaagcagcgu cuuucagugc uuugacgucc ugcugggcau ccagcagacu      960

gcugguggag gacaugcugc ucaguuccuc caggacauga gaagauauau gccaccagcu     1020

cacaggaacu uccugugcuc auuagaguca aaucccucag uccgugaguu uguccuuuca     1080

aaaggugaug cuggccugcg ggaagcuuau gacgccugug ugaaagcucu ggucucccug     1140

aggagcuacc aucugcaaau cgugacuaag uacauccuga uuccugcaag ccagcagcca     1200

aaggagaaua agaccucuga agacccuuca aaacuggaag ccaaaggaac uggaggcacu     1260

gauuuaauga auuuccugaa gacuguaaga aguacaacug agaaaucccu uuugaaggaa     1320

gguuaaugua acccaacaag agcacauuuu aucauagcag agacaucugu augcauuccu     1380

gucauuaccc auuguaacag agccacaaac uaauacuaug caauguuuua ccaauaaugc     1440

aauacaaaag accucaaaau accugugcau uucuuguagg aaaacaacaa aagguaauua     1500

uguguaauua uacuagaagu uuuguaaucu guaucuuauc auuggaauaa aaugacauuc     1560

aauaaauaaa aaugcauaag auauauucug ucggcugggc gcgguggcuc acgccuguaa     1620

ucccagcacu uugggaggcc gaggcgggcg gaucacaagg ucaggagauc gagaccaucu     1680

uggcuaacac ggugaaaccc cgucucuacu aaaaauacaa aaaauuagcc gggcgcggug     1740

gcgggcaccu guagucccag cuacucggga ggcugaggca ggagaauggc gugaaccugg     1800

gaggcggagc uugcagugag ccaagauugu gccacugcaa uccggccugg gcuaaagagc     1860

gggacuccgu cucaaaaaaa aaaaaaaaaa gauauauucu gucauaauaa auaaaaaugc     1920

auaagauaua aaaaaaaaaa aaaa                                            1944


<210>  42
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


<210>  43
<211>  1135
<212>  RNA
<213>  Homo sapiens

<400>  43
uuccuccucc gagagcggac agaucucugg gugcugggcg gucauggcgc uacuagaugu       60

augcggagcc ccccgagggc agcggccgga aucggcucuc ccgguugcgg gaagcgggcg      120

ucgcucggac ccaggacacu acaguuucuc uaugcgaucu ccagagcucg cuuuaccccg      180

gggaaugcag cccacagaau ucuuccaguc ccuggguggg gacggagaaa ggaacguuca      240

gauugagaug gcccauggca ccaccacgcu cgccuucaag uuccagcaug gagugauugc      300

agcaguggau ucucgggccu cagcuggguc cuacauuagu gccuuacggg ugaacaaggu      360

gauugagauu aacccuuacc ugcuuggcac caugucuggc ugugcagcag acugucagua      420

cugggagcgc cugcuggcca aggaaugcag gcuguacuau cugcgaaaug gagaacguau      480

uucagugucg gcagccucca agcugcuguc caacaugaug ugccaguacc ggggcauggg      540

ccucucuaug ggcaguauga ucuguggcug ggauaagaag gguccuggac ucuacuacgu      600

ggaugaacau gggacucggc ucucaggaaa uauguucucc acggguagug ggaacacuua      660

ugccuacggg gucauggaca guggcuaucg gccuaaucuu agcccugaag aggccuauga      720

ccuuggccgc agggcuauug cuuaugccac ucacagagac agcuauucug gaggcguugu      780

caauauguac cacaugaagg aagaugguug ggugaaagua gaaaguacag augucaguga      840

ccugcugcac caguaccggg aagccaauca auaauggugg ugguggcagc ugggcagguc      900

uccucuggga ggucuuggcc gacucaggga ccuaagccac guuaagucca aggagaagaa      960

gaggccuagc cugagccaaa gagagaguac gggcucagca gccagaggag gccggugaag     1020

ugcaucuucu gcguguucuc uauuugaaca agcauuuccc ccagggaagu uucugggugc     1080

cccacuaagu agaauaaaga aaaacgguua uaaauaaaaa aaaaaaaaaa aaaaa          1135


<210>  44
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Leu Leu Asp Val Cys Gly Ala Pro Arg Gly Gln Arg Pro Glu 
1               5                   10                  15      


Ser Ala Leu Pro Val Ala Gly Ser Gly Arg Arg Ser Asp Pro Gly His 
            20                  25                  30          


Tyr Ser Phe Ser Met Arg Ser Pro Glu Leu Ala Leu Pro Arg Gly Met 
        35                  40                  45              


Gln Pro Thr Glu Phe Phe Gln Ser Leu Gly Gly Asp Gly Glu Arg Asn 
    50                  55                  60                  


Val Gln Ile Glu Met Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe 
65                  70                  75                  80  


Gln His Gly Val Ile Ala Ala Val Asp Ser Arg Ala Ser Ala Gly Ser 
                85                  90                  95      


Tyr Ile Ser Ala Leu Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr 
            100                 105                 110         


Leu Leu Gly Thr Met Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu 
        115                 120                 125             


Arg Leu Leu Ala Lys Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu 
    130                 135                 140                 


Arg Ile Ser Val Ser Ala Ala Ser Lys Leu Leu Ser Asn Met Met Cys 
145                 150                 155                 160 


Gln Tyr Arg Gly Met Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp 
                165                 170                 175     


Asp Lys Lys Gly Pro Gly Leu Tyr Tyr Val Asp Glu His Gly Thr Arg 
            180                 185                 190         


Leu Ser Gly Asn Met Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr 
        195                 200                 205             


Gly Val Met Asp Ser Gly Tyr Arg Pro Asn Leu Ser Pro Glu Glu Ala 
    210                 215                 220                 


Tyr Asp Leu Gly Arg Arg Ala Ile Ala Tyr Ala Thr His Arg Asp Ser 
225                 230                 235                 240 


Tyr Ser Gly Gly Val Val Asn Met Tyr His Met Lys Glu Asp Gly Trp 
                245                 250                 255     


Val Lys Val Glu Ser Thr Asp Val Ser Asp Leu Leu His Gln Tyr Arg 
            260                 265                 270         


Glu Ala Asn Gln 
        275     


<210>  45
<211>  1048
<212>  RNA
<213>  Homo sapiens

<400>  45
gcgcguugug cgcuguccca gguuggaaac cagugcccca ggcggcgagg agagcggugc       60

cuugcaggga ugcugcgggc gggagcacca accggggacu uaccccgggc gggagaaguc      120

cacaccggga ccaccaucau ggcaguggag uuugacgggg gcguugugau ggguucugau      180

ucccgagugu cugcaggcga ggcgguggug aaccgagugu uugacaagcu guccccgcug      240

cacgagcgca ucuacugugc acucucuggu ucagcugcug augcccaagc cguggccgac      300

auggccgccu accagcugga gcuccauggg auagaacugg aggaaccucc acuuguuuug      360

gcugcugcaa auguggugag aaauaucagc uauaaauauc gagaggacuu gucugcacau      420

cucaugguag cuggcuggga ccaacgugaa ggaggucagg uauauggaac ccugggagga      480

augcugacuc gacagccuuu ugccauuggu ggcuccggca gcaccuuuau cuaugguuau      540

guggaugcag cauauaagcc aggcaugucu cccgaggagu gcaggcgcuu caccacagac      600

gcuauugcuc uggccaugag ccgggauggc ucaagcgggg gugucaucua ccuggucacu      660

auuacagcug ccggugugga ccaucgaguc aucuugggca augaacugcc aaaauucuau      720

gaugagugaa ccuuccccag acuucucuuu cuuauuuugu aauaaacucu cuagggccaa      780

aaccugguau ggucauuggg aaaugagugc ucagggagau ggagcuuagg ggaggugggu      840

gcuucccucc uagaugucag cauacacucu uucuucuuuu gucccagguc uaaaacaucu      900

uuccuagaga aaacaaaagg gacuaaacua gaaauauaaa gagcccuaua caugacaggu      960

gaucacguac ugaaugauuu ugaaguagua caaacaauaa aaauucucau uccgcaucau     1020

caugcggucc augaugauga ggccgcaa                                        1048


<210>  46
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu 
1               5                   10                  15      


Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val 
            20                  25                  30          


Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn 
        35                  40                  45              


Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala 
    50                  55                  60                  


Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala 
65                  70                  75                  80  


Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val 
                85                  90                  95      


Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu 
            100                 105                 110         


Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly 
        115                 120                 125             


Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe 
    130                 135                 140                 


Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala 
145                 150                 155                 160 


Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr 
                165                 170                 175     


Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val 
            180                 185                 190         


Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile 
        195                 200                 205             


Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu 
    210                 215                 


<210>  47
<211>  2974
<212>  RNA
<213>  Homo sapiens

<400>  47
gugugcguga uggagaaaau ugggcaccag ggcugcuccc gagauucuca gaucugauuu       60

ccacgcuugc uaccaaaaua gucugggcag gccacuuuug gaaguaggcg uuaucuagug      120

agcaggcggc cgcuuucgau uucgcuuucc ccuaaauggc ugagcuucuc gccagcgcag      180

gaucagccug uuccugggac uuuccgagag ccccgcccuc guucccuccc ccagccgcca      240

guaggggagg acucggcggu acccggagcu ucaggcccca ccggggcgcg gagaguccca      300

ggcccggccg ggaccgggac ggcguccgag ugccaauggc uagcucuagg ugucccgcuc      360

cccgcgggug ccgcugccuc cccggagcuu cucucgcaug gcuggggaca guacugcuac      420

uucucgccga cugggugcug cuccggaccg cgcugccccg cauauucucc cugcuggugc      480

ccaccgcgcu gccacugcuc cgggucuggg cggugggccu gagccgcugg gccgugcucu      540

ggcugggggc cugcgggguc cucagggcaa cgguuggcuc caagagcgaa aacgcaggug      600

cccagggcug gcuggcugcu uugaagccau uagcugcggc acugggcuug gcccugccgg      660

gacuugccuu guuccgagag cugaucucau ggggagcccc cggguccgcg gauagcacca      720

ggcuacugca cuggggaagu cacccuaccg ccuucguugu caguuaugca gcggcacugc      780

ccgcagcagc ccuguggcac aaacucggga gccucugggu gcccggcggu cagggcggcu      840

cuggaaaccc ugugcgucgg cuucuaggcu gccugggcuc ggagacgcgc cgccucucgc      900

uguuccuggu ccuggugguc cucuccucuc uuggggagau ggccauucca uucuuuacgg      960

gccgccucac ugacuggauu cuacaagaug gcucagccga uaccuucacu cgaaacuuaa     1020

cucucauguc cauucucacc auagccagug cagugcugga guucgugggu gacgggaucu     1080

auaacaacac caugggccac gugcacagcc acuugcaggg agagguguuu ggggcugucc     1140

ugcgccagga gacggaguuu uuccaacaga accagacagg uaacaucaug ucucggguaa     1200

cagaggacac guccacccug agugauucuc ugagugagaa ucugagcuua uuucuguggu     1260

accuggugcg aggccuaugu cucuugggga ucaugcucug gggaucagug ucccucacca     1320

uggucacccu gaucacccug ccucugcuuu uccuucugcc caagaaggug ggaaaauggu     1380

accaguugcu ggaagugcag gugcgggaau cucuggcaaa guccagccag guggccauug     1440

aggcucuguc ggccaugccu acaguucgaa gcuuugccaa cgaggagggc gaagcccaga     1500

aguuuaggga aaagcugcaa gaaauaaaga cacucaacca gaaggaggcu guggccuaug     1560

cagucaacuc cuggaccacu aguauuucag guaugcugcu gaaaguggga auccucuaca     1620

uuggugggca gcuggugacc aguggggcug uaagcagugg gaaccuuguc acauuuguuc     1680

ucuaccagau gcaguucacc caggcugugg agguacugcu cuccaucuac cccagaguac     1740

agaaggcugu gggcuccuca gagaaaauau uugaguaccu ggaccgcacc ccucgcugcc     1800

cacccagugg ucuguugacu cccuuacacu uggagggccu uguccaguuc caagaugucu     1860

ccuuugccua cccaaaccgc ccagaugucu uagugcuaca ggggcugaca uucacccuac     1920

gcccuggcga ggugacggcg cuggugggac ccaauggguc ugggaagagc acaguggcug     1980

cccugcugca gaaucuguac cagcccaccg ggggacagcu gcuguuggau gggaagcccc     2040

uuccccaaua ugagcaccgc uaccugcaca ggcagguggc ugcaguggga caagagccac     2100

agguauuugg aagaagucuu caagaaaaua uugccuaugg ccugacccag aagccaacua     2160

uggaggaaau cacagcugcu gcaguaaagu cuggggccca uaguuucauc ucuggacucc     2220

cucagggcua ugacacagag guagacgagg cugggagcca gcugucaggg ggucagcgac     2280

aggcaguggc guuggcccga gcauugaucc ggaaaccgug uguacuuauc cuggaugaug     2340

ccaccagugc ccuggaugca aacagccagu uacaggugga gcagcuccug uacgaaagcc     2400

cugagcggua cucccgcuca gugcuucuca ucacccagca ccucagccug guggagcagg     2460

cugaccacau ccucuuucug gaaggaggcg cuauccggga ggggggaacc caccagcagc     2520

ucauggagaa aaaggggugc uacugggcca uggugcaggc uccugcagau gcuccagaau     2580

gaaagccuuc ucagaccugc gcacuccauc ucccucccuu uucuucucuc ugugguggag     2640

aaccacagcu gcagaguagg cagcugccuc caggaugagu uacuugaaau uugccuugag     2700

uguguuaccu ccuuuccaag cuccucguga uaaugcagac uuccuggagu acaaacacag     2760

gauuuguaau uccuuacugu aacggaguuu agagccaggg cugaugcuuu gguguggcca     2820

gcacucugaa acugagaaau guucagaaug uacggaaaga ugaucagcua uuuucaacau     2880

aacugaaggc auaugcuggc ccauaaacac ccuguagguu cuugauauuu auaauaaaau     2940

ugguguuuug uaaaaaaaaa aaaaaaaaaa aaaa                                 2974


<210>  48
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Leu Leu Ala Ser Ala Gly Ser Ala Cys Ser Trp Asp Phe 
1               5                   10                  15      


Pro Arg Ala Pro Pro Ser Phe Pro Pro Pro Ala Ala Ser Arg Gly Gly 
            20                  25                  30          


Leu Gly Gly Thr Arg Ser Phe Arg Pro His Arg Gly Ala Glu Ser Pro 
        35                  40                  45              


Arg Pro Gly Arg Asp Arg Asp Gly Val Arg Val Pro Met Ala Ser Ser 
    50                  55                  60                  


Arg Cys Pro Ala Pro Arg Gly Cys Arg Cys Leu Pro Gly Ala Ser Leu 
65                  70                  75                  80  


Ala Trp Leu Gly Thr Val Leu Leu Leu Leu Ala Asp Trp Val Leu Leu 
                85                  90                  95      


Arg Thr Ala Leu Pro Arg Ile Phe Ser Leu Leu Val Pro Thr Ala Leu 
            100                 105                 110         


Pro Leu Leu Arg Val Trp Ala Val Gly Leu Ser Arg Trp Ala Val Leu 
        115                 120                 125             


Trp Leu Gly Ala Cys Gly Val Leu Arg Ala Thr Val Gly Ser Lys Ser 
    130                 135                 140                 


Glu Asn Ala Gly Ala Gln Gly Trp Leu Ala Ala Leu Lys Pro Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Gly Leu Ala Leu Pro Gly Leu Ala Leu Phe Arg Glu Leu 
                165                 170                 175     


Ile Ser Trp Gly Ala Pro Gly Ser Ala Asp Ser Thr Arg Leu Leu His 
            180                 185                 190         


Trp Gly Ser His Pro Thr Ala Phe Val Val Ser Tyr Ala Ala Ala Leu 
        195                 200                 205             


Pro Ala Ala Ala Leu Trp His Lys Leu Gly Ser Leu Trp Val Pro Gly 
    210                 215                 220                 


Gly Gln Gly Gly Ser Gly Asn Pro Val Arg Arg Leu Leu Gly Cys Leu 
225                 230                 235                 240 


Gly Ser Glu Thr Arg Arg Leu Ser Leu Phe Leu Val Leu Val Val Leu 
                245                 250                 255     


Ser Ser Leu Gly Glu Met Ala Ile Pro Phe Phe Thr Gly Arg Leu Thr 
            260                 265                 270         


Asp Trp Ile Leu Gln Asp Gly Ser Ala Asp Thr Phe Thr Arg Asn Leu 
        275                 280                 285             


Thr Leu Met Ser Ile Leu Thr Ile Ala Ser Ala Val Leu Glu Phe Val 
    290                 295                 300                 


Gly Asp Gly Ile Tyr Asn Asn Thr Met Gly His Val His Ser His Leu 
305                 310                 315                 320 


Gln Gly Glu Val Phe Gly Ala Val Leu Arg Gln Glu Thr Glu Phe Phe 
                325                 330                 335     


Gln Gln Asn Gln Thr Gly Asn Ile Met Ser Arg Val Thr Glu Asp Thr 
            340                 345                 350         


Ser Thr Leu Ser Asp Ser Leu Ser Glu Asn Leu Ser Leu Phe Leu Trp 
        355                 360                 365             


Tyr Leu Val Arg Gly Leu Cys Leu Leu Gly Ile Met Leu Trp Gly Ser 
    370                 375                 380                 


Val Ser Leu Thr Met Val Thr Leu Ile Thr Leu Pro Leu Leu Phe Leu 
385                 390                 395                 400 


Leu Pro Lys Lys Val Gly Lys Trp Tyr Gln Leu Leu Glu Val Gln Val 
                405                 410                 415     


Arg Glu Ser Leu Ala Lys Ser Ser Gln Val Ala Ile Glu Ala Leu Ser 
            420                 425                 430         


Ala Met Pro Thr Val Arg Ser Phe Ala Asn Glu Glu Gly Glu Ala Gln 
        435                 440                 445             


Lys Phe Arg Glu Lys Leu Gln Glu Ile Lys Thr Leu Asn Gln Lys Glu 
    450                 455                 460                 


Ala Val Ala Tyr Ala Val Asn Ser Trp Thr Thr Ser Ile Ser Gly Met 
465                 470                 475                 480 


Leu Leu Lys Val Gly Ile Leu Tyr Ile Gly Gly Gln Leu Val Thr Ser 
                485                 490                 495     


Gly Ala Val Ser Ser Gly Asn Leu Val Thr Phe Val Leu Tyr Gln Met 
            500                 505                 510         


Gln Phe Thr Gln Ala Val Glu Val Leu Leu Ser Ile Tyr Pro Arg Val 
        515                 520                 525             


Gln Lys Ala Val Gly Ser Ser Glu Lys Ile Phe Glu Tyr Leu Asp Arg 
    530                 535                 540                 


Thr Pro Arg Cys Pro Pro Ser Gly Leu Leu Thr Pro Leu His Leu Glu 
545                 550                 555                 560 


Gly Leu Val Gln Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg Pro 
                565                 570                 575     


Asp Val Leu Val Leu Gln Gly Leu Thr Phe Thr Leu Arg Pro Gly Glu 
            580                 585                 590         


Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val Ala 
        595                 600                 605             


Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Leu Leu Leu 
    610                 615                 620                 


Asp Gly Lys Pro Leu Pro Gln Tyr Glu His Arg Tyr Leu His Arg Gln 
625                 630                 635                 640 


Val Ala Ala Val Gly Gln Glu Pro Gln Val Phe Gly Arg Ser Leu Gln 
                645                 650                 655     


Glu Asn Ile Ala Tyr Gly Leu Thr Gln Lys Pro Thr Met Glu Glu Ile 
            660                 665                 670         


Thr Ala Ala Ala Val Lys Ser Gly Ala His Ser Phe Ile Ser Gly Leu 
        675                 680                 685             


Pro Gln Gly Tyr Asp Thr Glu Val Asp Glu Ala Gly Ser Gln Leu Ser 
    690                 695                 700                 


Gly Gly Gln Arg Gln Ala Val Ala Leu Ala Arg Ala Leu Ile Arg Lys 
705                 710                 715                 720 


Pro Cys Val Leu Ile Leu Asp Asp Ala Thr Ser Ala Leu Asp Ala Asn 
                725                 730                 735     


Ser Gln Leu Gln Val Glu Gln Leu Leu Tyr Glu Ser Pro Glu Arg Tyr 
            740                 745                 750         


Ser Arg Ser Val Leu Leu Ile Thr Gln His Leu Ser Leu Val Glu Gln 
        755                 760                 765             


Ala Asp His Ile Leu Phe Leu Glu Gly Gly Ala Ile Arg Glu Gly Gly 
    770                 775                 780                 


Thr His Gln Gln Leu Met Glu Lys Lys Gly Cys Tyr Trp Ala Met Val 
785                 790                 795                 800 


Gln Ala Pro Ala Asp Ala Pro Glu 
                805             


<210>  49
<211>  5732
<212>  RNA
<213>  Homo sapiens

<400>  49
agaaugaagg ccuuggcugg ggaagcgaaa gcgaaagcug cccgagcccu gacgcccgcc       60

cuggccgagc guagcuggcg gaccagagcc gguagcgagg uugggagaga cggagcggac      120

cucagcgcug aagcagaagu ccccggagcu gcggucuccc cgccgcggcu gagccaugcg      180

gcucccugac cugagacccu ggaccucccu gcugcuggug gacgcggcuu uacuguggcu      240

gcuucagggc ccucugggga cuuugcuucc ucaagggcug ccaggacuau ggcuggaggg      300

gacccugcgg cugggagggc ugugggggcu gcuaaagcua agagggcugc ugggauuugu      360

ggggacacug cugcucccgc ucugucuggc caccccccug acugucuccc ugagagcccu      420

ggucgcgggg gccucacgug cucccccagc cagagucgcu ucagccccuu ggagcuggcu      480

gcuggugggg uacggggcug cggggcucag cuggucacug ugggcuguuc ugagcccucc      540

uggagcccag gagaaggagc aggaccaggu gaacaacaaa gucuugaugu ggaggcugcu      600

gaagcucucc aggccggacc ugccucuccu cguugccgcc uucuucuucc uuguccuugc      660

uguuuugggu gagacauuaa ucccucacua uucuggucgu gugauugaca uccugggagg      720

ugauuuugac ccccaugccu uugccagugc caucuucuuc augugccucu ucuccuuugg      780

cagcucacug ucugcaggcu gccgaggagg cugcuucacc uacaccaugu cucgaaucaa      840

cuugcggauc cgggagcagc uuuucuccuc ccugcugcgc caggaccucg guuucuucca      900

ggagacuaag acaggggagc ugaacucacg gcugagcucg gauaccaccc ugaugaguaa      960

cuggcuuccu uuaaaugcca augugcucuu gcgaagccug gugaaagugg uggggcugua     1020

uggcuucaug cucagcauau cgccucgacu cacccuccuu ucucugcugc acaugcccuu     1080

cacaauagca gcggagaagg uguacaacac ccgccaucag gaagugcuuc gggagaucca     1140

ggaugcagug gccagggcgg ggcagguggu gcgggaagcc guuggagggc ugcagaccgu     1200

ucgcaguuuu ggggccgagg agcaugaagu cugucgcuau aaagaggccc uugaacaaug     1260

ucggcagcug uauuggcgga gagaccugga acgcgccuug uaccugcucg uaaggagggu     1320

gcugcacuug ggggugcaga ugcugaugcu gagcuguggg cugcagcaga ugcaggaugg     1380

ggagcucacc cagggcagcc ugcuuuccuu uaugaucuac caggagagcg uggggagcua     1440

ugugcagacc cugguauaca uauaugggga uaugcucagc aacgugggag cugcagagaa     1500

gguuuucucc uacauggacc gacagccaaa ucugccuuca ccuggcacgc uugcccccac     1560

cacucugcag gggguuguga aauuccaaga cgucuccuuu gcauauccca aucgcccuga     1620

caggccugug cucaaggggc ugacguuuac ccuacguccu ggugagguga cggcgcuggu     1680

gggacccaau gggucuggga agagcacagu ggcugcccug cugcagaauc uguaccagcc     1740

cacaggggga caggugcugc uggaugaaaa gcccaucuca caguaugaac acugcuaccu     1800

gcacagccag gugguuucag uugggcagga gccugugcug uucuccgguu cugugaggaa     1860

caacauugcu uaugggcugc agagcugcga agaugauaag gugauggcgg cugcccaggc     1920

ugcccacgca gaugacuuca uccaggaaau ggagcaugga auauacacag auguagggga     1980

gaagggaagc cagcuggcug cgggacagaa acaacgucug gccauugccc gggcccuugu     2040

acgagacccg cggguccuca uccuggauga ggcuacuagu gcccuagaug ugcagugcga     2100

gcaggcccug caggacugga auucccgugg ggaucgcaca gugcugguga uugcucacag     2160

gcugcagaca guucagcgcg cccaccagau ccuggugcuc caggagggca agcugcagaa     2220

gcuugcccag cucuaggagg gacaggaccu cuauucccgc cuggugcagc agcggcugau     2280

ggacugaggc cccagggaua cugggcccuc uucucagggg cgucuccagg acccagagcu     2340

guuccugcuu ugaguuuccc uagagcugug cggccagaua gcuguuccug aguugcaggc     2400

acgauggaga uuuggacacu gugugcuuuu ggugggguag agaggugggg uggggugggg     2460

ugggggcugu cuguguccag gaaacuuaau ucccugguga cuagagcuuu gccuggugau     2520

gaggaguauu uuguggcaua auacauauau uuuaaaauau uuuccuucuu acaugaacug     2580

uauacauuca uauagaaaau uuagacaaua uaaaaaagua caaagaagaa aaguaaaagu     2640

acccauuguu ucacuuccug gagauaacca uaguugcuau uuugcugccu gucccaucag     2700

ucguuuaucu guuguuugag auagaaauua accaaaaaug acauaaauau ucaugagauu     2760

gccuuccuau auccuuccuu guuccuacca gugucugcua uuuugaagaa gcuagggucu     2820

ggagggacag agaacaguuc ccugauuaac aguauuaaua gcgacauugg uaacagcuac     2880

cauuuauaga guuuuaaugg gaguaggagc uaugcuaagu guuuuucaug uauuaucguu     2940

uuuaaucauu auccccaacc cuaugagguu gguuauuauc cccauuuuac agaugaggaa     3000

acugaagcuc aaagaggcuc aaugacuuuc ccaagguggu cguaguggug gaguuggagu     3060

uugaacacag gccugacccu agaguccaca cccugaccca aucaauuaua uugcaucuug     3120

gguccauaaa cccuaaucca uaaucccauc aagaaaagcu cugcugcucu uagcucuaaa     3180

uaauucagaa ucuauucucu ucucuccagu cccguuguua uagucuucac ucauagacuu     3240

aagaugaucc caucaccaga gagguuucuc uaccauuagc uucccucuuc cggccauucu     3300

ucacaaaguc auuuuucuaa auucuguguc acauacgaug auggcauuuc uggaaauucc     3360

uucaggugcu cucaagcccu gcugcagaga uccuuuucag agcacacacu guuccagccc     3420

aucugucuca cccucuccug uuguauccag cuccacgaca aacuucugcc uuccccaaca     3480

ccuuugugcc uuugcauaug guguuuucuu gcccauuuuc ugcucgacuc gccccugauu     3540

uucaaguuca agacuuaacu caggguucag gucuuccagg aggccuuacu uaugucguca     3600

gucuggggaa cucuccaugu gcuucuauca cugugcgguu accucuuuca cagcccuuuu     3660

aaaguucuau cuucccuuuc ccaccuuuuu ugaccuucca cuagaccaug agcaccuggg     3720

cggaaagcca uauaucuuau uaagcuuuau aucugcuacc uggccgaggg ccuaauucau     3780

aguggagaau aaauagucaa uugaauaaau gaauaaauau cuccaccauc guacuaaucu     3840

uaauccuccc ugcccacucc caccacugaa aaugcaacau uguacacauc acugguuguu     3900

gggagggacu uaccuuggaa aguugcuauu cuaggaaaga gaaaccuuca uauuccugga     3960

aacagcaggu aguuuccagu gcuggcaaug aauuccccag aacugcuguu uuggauuuuu     4020

ucuugccugg cagcuguugg gagcagggug cagugaggau ggggugagag ugggcaguuu     4080

cuugugcaga uuugccuuuc uuucauccug gggcugacuu gcagcuccac acccauccau     4140

cucucaaauu ucacagaggg uaaaauaggc auuuggagag aaagaacucu ggccugauuc     4200

cuuucucucc cacaaauguc cuuuauucau aaaacaggaa uaauaauucc uguaucuccc     4260

aacuacaugg aagcugcagc ccucacagaa gaagaugauc ugagaaauuc uuugauuucc     4320

ucaguacagu uauacccaug caucauaaua cuuuaagccu ggaaggcauc uuaaaaauaa     4380

ugcaacaguc aaaccuaauu uuacagagaa acugacauga aaucacgcag cuaaucauga     4440

uaaagcuggg uggaaaacuu aucuugaugg gcaguacagg aagaugcagu agaccuuaag     4500

auguccugaa aguuucuuau cucaggggaa acucccaggu aggcuuuaug ucagggacac     4560

agaaaaaugc ucccugaaag ucaaaauauu cgggcuagac agacaaauuc cuguaagugu     4620

gguuugucug ggaaccacag augucacuaa uccugguuug cuccagaguu cuuuuuguuc     4680

acuccuaccc cccaucacca uuugauugau cuccuuaccc uguaauuucc ccuucuuguc     4740

gcuuaccugc aguaucuuuc ccacccaggc augccuuauu cuuucuaaag gaaaguauga     4800

auggagaggg gaaagcuugg gaaacugaua gauuuccuug gaugccaaaa caccuccaua     4860

gccugucugc ccggcccuau guggaaacag cauugaguuu caaguccuuu augccuccac     4920

ccagggauag ccacuuguaa uccacauggc aauugugaaa caagcaggaa augcguaauu     4980

gucagaauuu uguggggaaa ggacuaggga auaaggaaaa caaagaucuu ccuuguguuu     5040

uagagcuguc agcuagagga gcaccugcuu gagucugaug ccaucuaaug gucccagaag     5100

aaacuggguu uugaaccuag aguuccaugg acucuuagga auuagacuac uacuacuacu     5160

aagcauucac uggugcuuac uaugugcuau ugcugugcca aguaucugaa accugucuuc     5220

uuaccuuauu uuucaagaua auucuaugug gcagguauua cuaucucaau ucuaagagug     5280

agaaaaugga guuuuagaaa cauuuacuaa cuugccuggg ucacauagcu aaggaagagg     5340

uggacuugcc cagcuuugca uaaaacuccu caaaagaguu gccuauacuc ccugacucca     5400

cuuaucuucc uacuauccuc uuuuuaaaau auauuauuua uuuauuuaaa uaagcaauau     5460

augaaugugg uuugaaauuc aaaagacaca aagaaguaua cagaggaaag ccucacucuc     5520

aauccuucuc aagguuugcu aauuccucuu gcauaggcaa uccguucuuc cagcuuugug     5580

uuuaucuuuc cagagaaguu uacuguguau uaagcaaaua uguauaucuu uauucuugcu     5640

caguauuuuc gcaaacagca gcugucuaag uucacuguuc ugaacuuuau uuuuuaaauu     5700

aaaaauauau ggcuauguag uauucuauuu ua                                   5732


<210>  50
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Arg Leu Pro Asp Leu Arg Pro Trp Thr Ser Leu Leu Leu Val Asp 
1               5                   10                  15      


Ala Ala Leu Leu Trp Leu Leu Gln Gly Pro Leu Gly Thr Leu Leu Pro 
            20                  25                  30          


Gln Gly Leu Pro Gly Leu Trp Leu Glu Gly Thr Leu Arg Leu Gly Gly 
        35                  40                  45              


Leu Trp Gly Leu Leu Lys Leu Arg Gly Leu Leu Gly Phe Val Gly Thr 
    50                  55                  60                  


Leu Leu Leu Pro Leu Cys Leu Ala Thr Pro Leu Thr Val Ser Leu Arg 
65                  70                  75                  80  


Ala Leu Val Ala Gly Ala Ser Arg Ala Pro Pro Ala Arg Val Ala Ser 
                85                  90                  95      


Ala Pro Trp Ser Trp Leu Leu Val Gly Tyr Gly Ala Ala Gly Leu Ser 
            100                 105                 110         


Trp Ser Leu Trp Ala Val Leu Ser Pro Pro Gly Ala Gln Glu Lys Glu 
        115                 120                 125             


Gln Asp Gln Val Asn Asn Lys Val Leu Met Trp Arg Leu Leu Lys Leu 
    130                 135                 140                 


Ser Arg Pro Asp Leu Pro Leu Leu Val Ala Ala Phe Phe Phe Leu Val 
145                 150                 155                 160 


Leu Ala Val Leu Gly Glu Thr Leu Ile Pro His Tyr Ser Gly Arg Val 
                165                 170                 175     


Ile Asp Ile Leu Gly Gly Asp Phe Asp Pro His Ala Phe Ala Ser Ala 
            180                 185                 190         


Ile Phe Phe Met Cys Leu Phe Ser Phe Gly Ser Ser Leu Ser Ala Gly 
        195                 200                 205             


Cys Arg Gly Gly Cys Phe Thr Tyr Thr Met Ser Arg Ile Asn Leu Arg 
    210                 215                 220                 


Ile Arg Glu Gln Leu Phe Ser Ser Leu Leu Arg Gln Asp Leu Gly Phe 
225                 230                 235                 240 


Phe Gln Glu Thr Lys Thr Gly Glu Leu Asn Ser Arg Leu Ser Ser Asp 
                245                 250                 255     


Thr Thr Leu Met Ser Asn Trp Leu Pro Leu Asn Ala Asn Val Leu Leu 
            260                 265                 270         


Arg Ser Leu Val Lys Val Val Gly Leu Tyr Gly Phe Met Leu Ser Ile 
        275                 280                 285             


Ser Pro Arg Leu Thr Leu Leu Ser Leu Leu His Met Pro Phe Thr Ile 
    290                 295                 300                 


Ala Ala Glu Lys Val Tyr Asn Thr Arg His Gln Glu Val Leu Arg Glu 
305                 310                 315                 320 


Ile Gln Asp Ala Val Ala Arg Ala Gly Gln Val Val Arg Glu Ala Val 
                325                 330                 335     


Gly Gly Leu Gln Thr Val Arg Ser Phe Gly Ala Glu Glu His Glu Val 
            340                 345                 350         


Cys Arg Tyr Lys Glu Ala Leu Glu Gln Cys Arg Gln Leu Tyr Trp Arg 
        355                 360                 365             


Arg Asp Leu Glu Arg Ala Leu Tyr Leu Leu Val Arg Arg Val Leu His 
    370                 375                 380                 


Leu Gly Val Gln Met Leu Met Leu Ser Cys Gly Leu Gln Gln Met Gln 
385                 390                 395                 400 


Asp Gly Glu Leu Thr Gln Gly Ser Leu Leu Ser Phe Met Ile Tyr Gln 
                405                 410                 415     


Glu Ser Val Gly Ser Tyr Val Gln Thr Leu Val Tyr Ile Tyr Gly Asp 
            420                 425                 430         


Met Leu Ser Asn Val Gly Ala Ala Glu Lys Val Phe Ser Tyr Met Asp 
        435                 440                 445             


Arg Gln Pro Asn Leu Pro Ser Pro Gly Thr Leu Ala Pro Thr Thr Leu 
    450                 455                 460                 


Gln Gly Val Val Lys Phe Gln Asp Val Ser Phe Ala Tyr Pro Asn Arg 
465                 470                 475                 480 


Pro Asp Arg Pro Val Leu Lys Gly Leu Thr Phe Thr Leu Arg Pro Gly 
                485                 490                 495     


Glu Val Thr Ala Leu Val Gly Pro Asn Gly Ser Gly Lys Ser Thr Val 
            500                 505                 510         


Ala Ala Leu Leu Gln Asn Leu Tyr Gln Pro Thr Gly Gly Gln Val Leu 
        515                 520                 525             


Leu Asp Glu Lys Pro Ile Ser Gln Tyr Glu His Cys Tyr Leu His Ser 
    530                 535                 540                 


Gln Val Val Ser Val Gly Gln Glu Pro Val Leu Phe Ser Gly Ser Val 
545                 550                 555                 560 


Arg Asn Asn Ile Ala Tyr Gly Leu Gln Ser Cys Glu Asp Asp Lys Val 
                565                 570                 575     


Met Ala Ala Ala Gln Ala Ala His Ala Asp Asp Phe Ile Gln Glu Met 
            580                 585                 590         


Glu His Gly Ile Tyr Thr Asp Val Gly Glu Lys Gly Ser Gln Leu Ala 
        595                 600                 605             


Ala Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg Ala Leu Val Arg Asp 
    610                 615                 620                 


Pro Arg Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Gln 
625                 630                 635                 640 


Cys Glu Gln Ala Leu Gln Asp Trp Asn Ser Arg Gly Asp Arg Thr Val 
                645                 650                 655     


Leu Val Ile Ala His Arg Leu Gln Thr Val Gln Arg Ala His Gln Ile 
            660                 665                 670         


Leu Val Leu Gln Glu Gly Lys Leu Gln Lys Leu Ala Gln Leu 
        675                 680                 685     


<210>  51
<211>  849
<212>  RNA
<213>  Homo sapiens

<400>  51
augaggaacu ccuauagauu ucuggcaucc ucucucucag uugucguuuc ucuccugcua       60

auuccugaag augucuguga aaaaauuauu ggaggaaaug aaguaacucc ucauucaaga      120

cccuacaugg uccuacuuag ucuugacaga aaaaccaucu gugcuggggc uuugauugca      180

aaagacuggg uguugacugc agcucacugu aacuugaaca aaagguccca ggucauucuu      240

ggggcucacu caauaaccag ggaagagcca acaaaacaga uaaugcuugu uaagaaagag      300

uuucccuauc caugcuauga cccagccaca cgcgaaggug accuuaaacu uuuacagcug      360

acggaaaaag caaaaauuaa caaauaugug acuauccuuc aucuaccuaa aaagggggau      420

gaugugaaac caggaaccau gugccaaguu gcaggguggg ggaggacuca caauagugca      480

ucuugguccg auacucugag agaagucaau aucaccauca uagacagaaa agucugcaau      540

gaucgaaauc acuauaauuu uaacccugug auuggaauga auaugguuug ugcuggaagc      600

cuccgaggug gaagagacuc gugcaaugga gauucuggaa gcccuuuguu gugcgagggu      660

guuuuccgag gggucacuuc cuuuggccuu gaaaauaaau gcggagaccc ucgugggccu      720

ggugucuaua uucuucucuc aaagaaacac cucaacugga uaauuaugac uaucaaggga      780

gcaguuuaaa uaaccguuuc cuuucauuua cuguggcuuc uuaaucuuuu cacaaauaaa      840

aucaauuug                                                              849


<210>  52
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val 
1               5                   10                  15      


Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly 
            20                  25                  30          


Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu 
        35                  40                  45              


Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val 
    50                  55                  60                  


Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu 
                85                  90                  95      


Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu 
            100                 105                 110         


Gly Asp Leu Lys Leu Leu Gln Leu Met Glu Lys Ala Lys Ile Asn Lys 
        115                 120                 125             


Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro 
    130                 135                 140                 


Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala 
145                 150                 155                 160 


Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg 
                165                 170                 175     


Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly 
            180                 185                 190         


Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys 
        195                 200                 205             


Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly 
    210                 215                 220                 


Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro 
225                 230                 235                 240 


Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met 
                245                 250                 255     


Thr Ile Lys Gly Ala Val 
            260         


<210>  53
<211>  934
<212>  RNA
<213>  Homo sapiens

<400>  53
ugagaagaug caaccaaucc ugcuucugcu ggccuuccuc cugcugccca gggcagaugc       60

aggggagauc aucgggggac augaggccaa gccccacucc cgccccuaca uggcuuaucu      120

uaugaucugg gaucagaagu cucugaagag gugcgguggc uuccugauac aagacgacuu      180

cgugcugaca gcugcucacu guuggggaag cuccauaaau gucaccuugg gggcccacaa      240

uaucaaagaa caggagccga cccagcaguu uaucccugug aaaagaccca ucccccaucc      300

agccuauaau ccuaagaacu ucuccaacga caucaugcua cugcagcugg agagaaaggc      360

caagcggacc agagcugugc agccccucag gcuaccuagc aacaaggccc aggugaagcc      420

agggcagaca ugcagugugg ccggcugggg gcagacggcc ccccugggaa aacacucaca      480

cacacuacaa gaggugaaga ugacagugca ggaagaucga aagugcgaau cugacuuacg      540

ccauuauuac gacaguacca uugaguugug cgugggggac ccagagauua aaaagacuuc      600

cuuuaagggg gacucuggag gcccucuugu guguaacaag guggcccagg gcauugucuc      660

cuauggacga aacaauggca ugccuccacg agccugcacc aaagucucaa gcuuuguaca      720

cuggauaaag aaaaccauga aacgcuacua acuacaggaa gcaaacuaag cccccgcugu      780

aaugaaacac cuucucugga gccaagucca gauuuacacu gggagaggug ccagcaacug      840

aauaaauacc ucucccagug uaaaucugga gccaagucca gauuuacacu gggagaggug      900

ccagcaacug aauaaauacc ucuuagcuga gugg                                  934


<210>  54
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  55
<211>  7123
<212>  RNA
<213>  Homo sapiens

<400>  55
aucgaggucc gcgggaggcu cggagcgcgc caggcggaca cuccucucgg cuccuccccg       60

gcagcggcgg cggcucggag cgggcuccgg ggcucgggug cagcggccag cgggcgccug      120

gcggcgagga uuacccgggg aagugguugu cuccuggcug gagccgcgag acgggcgcuc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggacuc uggcggccgg gucguuggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgucgcgc ucaccauggu cagcuacugg      300

gacaccgggg uccugcugug cgcgcugcuc agcugucugc uucucacagg aucuaguuca      360

gguucaaaau uaaaagaucc ugaacugagu uuaaaaggca cccagcacau caugcaagca      420

ggccagacac ugcaucucca augcaggggg gaagcagccc auaaaugguc uuugccugaa      480

auggugagua aggaaagcga aaggcugagc auaacuaaau cugccugugg aagaaauggc      540

aaacaauucu gcaguacuuu aaccuugaac acagcucaag caaaccacac uggcuucuac      600

agcugcaaau aucuagcugu accuacuuca aagaagaagg aaacagaauc ugcaaucuau      660

auauuuauua gugauacagg uagaccuuuc guagagaugu acagugaaau ccccgaaauu      720

auacacauga cugaaggaag ggagcucguc auucccugcc ggguuacguc accuaacauc      780

acuguuacuu uaaaaaaguu uccacuugac acuuugaucc cugauggaaa acgcauaauc      840

ugggacagua gaaagggcuu caucauauca aaugcaacgu acaaagaaau agggcuucug      900

accugugaag caacagucaa ugggcauuug uauaagacaa acuaucucac acaucgacaa      960

accaauacaa ucauagaugu ccaaauaagc acaccacgcc cagucaaauu acuuagaggc     1020

cauacucuug uccucaauug uacugcuacc acucccuuga acacgagagu ucaaaugacc     1080

uggaguuacc cugaugaaaa aaauaagaga gcuuccguaa ggcgacgaau ugaccaaagc     1140

aauucccaug ccaacauauu cuacaguguu cuuacuauug acaaaaugca gaacaaagac     1200

aaaggacuuu auacuugucg uguaaggagu ggaccaucau ucaaaucugu uaacaccuca     1260

gugcauauau augauaaagc auucaucacu gugaaacauc gaaaacagca ggugcuugaa     1320

accguagcug gcaagcgguc uuaccggcuc ucuaugaaag ugaaggcauu ucccucgccg     1380

gaaguuguau gguuaaaaga uggguuaccu gcgacugaga aaucugcucg cuauuugacu     1440

cguggcuacu cguuaauuau caaggacgua acugaagagg augcagggaa uuauacaauc     1500

uugcugagca uaaaacaguc aaauguguuu aaaaaccuca cugccacucu aauugucaau     1560

gugaaacccc agauuuacga aaaggccgug ucaucguuuc cagacccggc ucucuaccca     1620

cugggcagca gacaaauccu gacuuguacc gcauauggua ucccucaacc uacaaucaag     1680

ugguucuggc accccuguaa ccauaaucau uccgaagcaa ggugugacuu uuguuccaau     1740

aaugaagagu ccuuuauccu ggaugcugac agcaacaugg gaaacagaau ugagagcauc     1800

acucagcgca uggcaauaau agaaggaaag aauaagaugg cuagcaccuu gguuguggcu     1860

gacucuagaa uuucuggaau cuacauuugc auagcuucca auaaaguugg gacuguggga     1920

agaaacauaa gcuuuuauau cacagaugug ccaaaugggu uucauguuaa cuuggaaaaa     1980

augccgacgg aaggagagga ccugaaacug ucuugcacag uuaacaaguu cuuauacaga     2040

gacguuacuu ggauuuuacu gcggacaguu aauaacagaa caaugcacua caguauuagc     2100

aagcaaaaaa uggccaucac uaaggagcac uccaucacuc uuaaucuuac caucaugaau     2160

guuucccugc aagauucagg caccuaugcc ugcagagcca ggaauguaua cacaggggaa     2220

gaaauccucc agaagaaaga aauuacaauc agagaucagg aagcaccaua ccuccugcga     2280

aaccucagug aucacacagu ggccaucagc aguuccacca cuuuagacug ucaugcuaau     2340

gguguccccg agccucagau cacuugguuu aaaaacaacc acaaaauaca acaagagccu     2400

ggaauuauuu uaggaccagg aagcagcacg cuguuuauug aaagagucac agaagaggau     2460

gaaggugucu aucacugcaa agccaccaac cagaagggcu cuguggaaag uucagcauac     2520

cucacuguuc aaggaaccuc ggacaagucu aaucuggagc ugaucacucu aacaugcacc     2580

uguguggcug cgacucucuu cuggcuccua uuaacccucu uuauccgaaa aaugaaaagg     2640

ucuucuucug aaauaaagac ugacuaccua ucaauuauaa uggacccaga ugaaguuccu     2700

uuggaugagc agugugagcg gcucccuuau gaugccagca agugggaguu ugcccgggag     2760

agacuuaaac ugggcaaauc acuuggaaga ggggcuuuug gaaaaguggu ucaagcauca     2820

gcauuuggca uuaagaaauc accuacgugc cggacugugg cugugaaaau gcugaaagag     2880

ggggccacgg ccagcgagua caaagcucug augacugagc uaaaaaucuu gacccacauu     2940

ggccaccauc ugaacguggu uaaccugcug ggagccugca ccaagcaagg agggccucug     3000

auggugauug uugaauacug caaauaugga aaucucucca acuaccucaa gagcaaacgu     3060

gacuuauuuu uucucaacaa ggaugcagca cuacacaugg agccuaagaa agaaaaaaug     3120

gagccaggcc uggaacaagg caagaaacca agacuagaua gcgucaccag cagcgaaagc     3180

uuugcgagcu ccggcuuuca ggaagauaaa agucugagug auguugagga agaggaggau     3240

ucugacgguu ucuacaagga gcccaucacu auggaagauc ugauuucuua caguuuucaa     3300

guggccagag gcauggaguu ccugucuucc agaaagugca uucaucggga ccuggcagcg     3360

agaaacauuc uuuuaucuga gaacaacgug gugaagauuu gugauuuugg ccuugcccgg     3420

gauauuuaua agaaccccga uuaugugaga aaaggagaua cucgacuucc ucugaaaugg     3480

auggcuccug aaucuaucuu ugacaaaauc uacagcacca agagcgacgu guggucuuac     3540

ggaguauugc ugugggaaau cuucuccuua ggugggucuc cauacccagg aguacaaaug     3600

gaugaggacu uuugcagucg ccugagggaa ggcaugagga ugagagcucc ugaguacucu     3660

acuccugaaa ucuaucagau caugcuggac ugcuggcaca gagacccaaa agaaaggcca     3720

agauuugcag aacuugugga aaaacuaggu gauuugcuuc aagcaaaugu acaacaggau     3780

gguaaagacu acaucccaau caaugccaua cugacaggaa auaguggguu uacauacuca     3840

acuccugccu ucucugagga cuucuucaag gaaaguauuu cagcuccgaa guuuaauuca     3900

ggaagcucug augaugucag auacguaaau gcuuucaagu ucaugagccu ggaaagaauc     3960

aaaaccuuug aagaacuuuu accgaaugcc accuccaugu uugaugacua ccagggcgac     4020

agcagcacuc uguuggccuc ucccaugcug aagcgcuuca ccuggacuga cagcaaaccc     4080

aaggccucgc ucaagauuga cuugagagua accaguaaaa guaaggaguc ggggcugucu     4140

gaugucagca ggcccaguuu cugccauucc agcugugggc acgucagcga aggcaagcgc     4200

agguucaccu acgaccacgc ugagcuggaa aggaaaaucg cgugcugcuc cccgccccca     4260

gacuacaacu cggugguccu guacuccacc ccacccaucu agaguuugac acgaagccuu     4320

auuucuagaa gcacaugugu auuuauaccc ccaggaaacu agcuuuugcc aguauuaugc     4380

auauauaagu uuacaccuuu aucuuuccau gggagccagc ugcuuuuugu gauuuuuuua     4440

auagugcuuu uuuuuuuuug acuaacaaga auguaacucc agauagagaa auagugacaa     4500

gugaagaaca cuacugcuaa auccucaugu uacucagugu uagagaaauc cuuccuaaac     4560

ccaaugacuu cccugcucca acccccgcca ccucagggca cgcaggacca guuugauuga     4620

ggagcugcac ugaucaccca augcaucacg uaccccacug ggccagcccu gcagcccaaa     4680

acccagggca acaagcccgu uagccccagg gaucacuggc uggccugagc aacaucucgg     4740

gaguccucua gcaggccuaa gacaugugag gaggaaaagg aaaaaaagca aaaagcaagg     4800

gagaaaagag aaaccgggag aaggcaugag aaagaauuug agacgcacca ugugggcacg     4860

gagggggacg gggcucagca augccauuuc aguggcuucc cagcucugac ccuucuacau     4920

uugagggccc agccaggagc agauggacag cgaugagggg acauuuucug gauucuggga     4980

ggcaagaaaa ggacaaauau cuuuuuugga acuaaagcaa auuuuagaac uuuaccuaug     5040

gaagugguuc uauguccauu cucauucgug gcauguuuug auuuguagca cugagggugg     5100

cacucaacuc ugagcccaua cuuuuggcuc cucuaguaag augcacugaa aacuuagcca     5160

gaguuagguu gucuccaggc caugauggcc uuacacugaa aaugucacau ucuauuuugg     5220

guauuaauau auaguccaga cacuuaacuc aauuucuugg uauuauucug uuuugcacag     5280

uuaguuguga aagaaagcug agaagaauga aaaugcaguc cugaggagag gaguuuucuc     5340

cauaucaaaa cgagggcuga uggaggaaaa aggucaauaa ggucaaggga aaaccccguc     5400

ucuauaccaa ccaaaccaau ucaccaacac aguugggacc caaaacacag gaagucaguc     5460

acguuuccuu uucauuuaau ggggauucca cuaucucaca cuaaucugaa aggaugugga     5520

agagcauuag cuggcgcaua uuaagcacuu uaagcuccuu gaguaaaaag gugguaugua     5580

auuuaugcaa gguauuucuc caguugggac ucaggauauu aguuaaugag ccaucacuag     5640

aagaaaagcc cauuuucaac ugcuuugaaa cuugccuggg gucugagcau gaugggaaua     5700

gggagacagg guaggaaagg gcgccuacuc uucagggucu aaagaucaag ugggccuugg     5760

aucgcuaagc uggcucuguu ugaugcuauu uaugcaaguu agggucuaug uauuuaugau     5820

gucugcaccu ucugcagcca gucagaagcu ggagaggcaa caguggauug cugcuucuug     5880

gggagaagag uaugcuuccu uuuauccaug uaauuuaacu guagaaccug agcucuaagu     5940

aaccgaagaa uguaugccuc uguucuuaug ugccacaucc uuguuuaaag gcucucugua     6000

ugaagagaug ggaccgucau cagcacauuc ccuagugagc cuacuggcuc cuggcagcgg     6060

cuuuugugga agacucacua gccagaagag aggaguggga caguccucuc caccaagauc     6120

uaaauccaaa caaaagcagg cuagagccag aagagaggac aaaucuuugu ucuuccucuu     6180

cuuuacauac gcaaaccacc ugugacagcu ggcaauuuua uaaaucaggu aacuggaagg     6240

agguuaaaca cagaaaaaag aagaccucag ucaauucucu acuuuuuuuu uuuuuuccaa     6300

aucagauaau agcccagcaa auagugauaa caaauaaaac cuuagcuauu caugucuuga     6360

uuucaauaau uaauucuuaa ucauuaagag accauaauaa auacuccuuu ucaagagaaa     6420

agcaaaacca uuagaauugu uacucagcuc cuucaaacuc agguuuguag cauacaugag     6480

uccauccauc agucaaagaa ugguuccauc uggagucuua auguagaaag aaaaauggag     6540

acuuguaaua augagcuagu uacaaagugc uuguucauua aaauagcacu gaaaauugaa     6600

acaugaauua acugauaaua uuccaaucau uugccauuua ugacaaaaau gguuggcacu     6660

aacaaagaac gagcacuucc uuucagaguu ucugagauaa uguacgugga acagucuggg     6720

uggaaugggg cugaaaccau gugcaagucu gugucuuguc aguccaagaa gugacaccga     6780

gauguuaauu uuagggaccc gugccuuguu uccuagccca caagaaugca aacaucaaac     6840

agauacucgc uagccucauu uaaauugauu aaaggaggag ugcaucuuug gccgacagug     6900

guguaacugu augugugugu gugugugugu gugugugugu gugugugggu guaugugugu     6960

uuugugcaua acuauuuaag gaaacuggaa uuuuaaaguu acuuuuauac aaaccaagaa     7020

uauaugcuac agauauaaga cagacauggu uugguccuau auuucuaguc augaugaaug     7080

uauuuuguau accaucuuca uauaauaaac uuccaaaaac aca                       7123


<210>  56
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  57
<211>  2545
<212>  RNA
<213>  Homo sapiens

<400>  57
auccaauaca ggagugacuu ggaacuccau ucuaucacua ugaagaaaag ugguguucuu       60

uuccucuugg gcaucaucuu gcugguucug auuggagugc aaggaacccc aguagugaga      120

aagggucgcu guuccugcau cagcaccaac caagggacua uccaccuaca auccuugaaa      180

gaccuuaaac aauuugcccc aagcccuucc ugcgagaaaa uugaaaucau ugcuacacug      240

aagaauggag uucaaacaug ucuaaaccca gauucagcag augugaagga acugauuaaa      300

aagugggaga aacaggucag ccaaaagaaa aagcaaaaga augggaaaaa acaucaaaaa      360

aagaaaguuc ugaaaguucg aaaaucucaa cguucucguc aaaagaagac uacauaagag      420

accacuucac caauaaguau ucuguguuaa aaauguucua uuuuaauuau accgcuauca      480

uuccaaagga ggauggcaua uaauacaaag gcuuauuaau uugacuagaa aauuuaaaac      540

auuacucuga aauuguaacu aaaguuagaa aguugauuuu aagaauccaa acguuaagaa      600

uuguuaaagg cuaugauugu cuuuguucuu cuaccaccca ccaguugaau uucaucaugc      660

uuaaggccau gauuuuagca auacccaugu cuacacagau guucacccaa ccacauccca      720

cucacaacag cugccuggaa gagcagcccu aggcuuccac guacugcagc cuccagagag      780

uaucugaggc acaugucagc aaguccuaag ccuguuagca ugcuggugag ccaagcaguu      840

ugaaauugag cuggaccuca ccaagcugcu guggccauca accucuguau uugaaucagc      900

cuacaggccu cacacacaau gugucugaga gauucaugcu gauuguuauu ggguaucacc      960

acuggagauc accagugugu ggcuuucaga gccuccuuuc uggcuuugga agccauguga     1020

uuccaucuug cccgcucagg cugaccacuu uauuucuuuu uguuccccuu ugcuucauuc     1080

aagucagcuc uucuccaucc uaccacaaug cagugccuuu cuucucucca gugcaccugu     1140

cauaugcucu gauuuaucug agucaacucc uuucucaucu uguccccaac accccacaga     1200

agugcuuucu ucucccaauu cauccucacu caguccagcu uaguucaagu ccugccucuu     1260

aaauaaaccu uuuuggacac acaaauuauc uuaaaacucc uguuucacuu gguucaguac     1320

cacaugggug aacacucaau gguuaacuaa uucuugggug uuuauccuau cucuccaacc     1380

agauugucag cuccuugagg gcaagagcca caguauauuu cccuguuucu uccacagugc     1440

cuaauaauac uguggaacua gguuuuaaua auuuuuuaau ugauguuguu augggcagga     1500

uggcaaccag accauugucu cagagcaggu gcuggcucuu uccuggcuac uccauguugg     1560

cuagccucug guaaccucuu acuuauuauc uucaggacac ucacuacagg gaccagggau     1620

gaugcaacau ccuugucuuu uuaugacagg auguuugcuc agcuucucca acaauaagaa     1680

gcacguggua aaacacuugc ggauauucug gacuguuuuu aaaaaauaua caguuuaccg     1740

aaaaucauau aaucuuacaa ugaaaaggac uuuauagauc agccagugac caaccuuuuc     1800

ccaaccauac aaaaauuccu uuucccgaag gaaaagggcu uucucaauaa gccucagcuu     1860

ucuaagaucu aacaagauag ccaccgagau ccuuaucgaa acucauuuua ggcaaauaug     1920

aguuuuauug uccguuuacu uguuucagag uuuguauugu gauuaucaau uaccacacca     1980

ucucccauga agaaagggaa cggugaagua cuaagcgcua gaggaagcag ccaagucggu     2040

uaguggaagc augauuggug cccaguuagc cucugcagga uguggaaacc uccuuccagg     2100

ggagguucag ugaauugugu aggagagguu gucuguggcc agaauuuaaa ccuauacuca     2160

cuuucccaaa uugaaucacu gcucacacug cugaugauuu agagugcugu ccgguggaga     2220

ucccacccga acgucuuauc uaaucaugaa acucccuagu uccuucaugu aacuucccug     2280

aaaaaucuaa guguuucaua aauuugagag ucugugaccc acuuaccuug caucucacag     2340

guagacagua uauaacuaac aaccaaagac uacauauugu cacugacaca cacguuauaa     2400

ucauuuauca uauauauaca uacaugcaua cacucucaaa gcaaauaauu uuucacuuca     2460

aaacaguauu gacuuguaua ccuuguaauu ugaaauauuu ucuuuguuaa aauagaaugg     2520

uaucaauaaa uagaccauua aucag                                           2545


<210>  58
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  59
<211>  1172
<212>  RNA
<213>  Homo sapiens

<400>  59
gagacauucc ucaauugcuu agacauauuc ugagccuaca gcagaggaac cuccagucuc       60

agcaccauga aucaaacugc gauucugauu ugcugccuua ucuuucugac ucuaaguggc      120

auucaaggag uaccucucuc uagaaccgua cgcuguaccu gcaucagcau uaguaaucaa      180

ccuguuaauc caaggucuuu agaaaaacuu gaaauuauuc cugcaagcca auuuugucca      240

cguguugaga ucauugcuac aaugaaaaag aagggugaga agagaugucu gaauccagaa      300

ucgaaggcca ucaagaauuu acugaaagca guuagcaagg aaaugucuaa aagaucuccu      360

uaaaaccaga ggggagcaaa aucgaugcag ugcuuccaag gauggaccac acagaggcug      420

ccucucccau cacuucccua cauggaguau augucaagcc auaauuguuc uuaguuugca      480

guuacacuaa aaggugacca augaugguca ccaaaucagc ugcuacuacu ccuguaggaa      540

gguuaauguu caucauccua agcuauucag uaauaacucu acccuggcac uauaauguaa      600

gcucuacuga ggugcuaugu ucuuagugga uguucugacc cugcuucaaa uauuucccuc      660

accuuuccca ucuuccaagg guacuaagga aucuuucugc uuugggguuu aucagaauuc      720

ucagaaucuc aaauaacuaa aagguaugca aucaaaucug cuuuuuaaag aaugcucuuu      780

acuucaugga cuuccacugc cauccuccca aggggcccaa auucuuucag uggcuaccua      840

cauacaauuc caaacacaua caggaaggua gaaauaucug aaaauguaug uguaaguauu      900

cuuauuuaau gaaagacugu acaaaguaua agucuuagau guauauauuu ccuauauugu      960

uuucagugua cauggaauaa cauguaauua aguacuaugu aucaaugagu aacaggaaaa     1020

uuuuaaaaau acagauagau auaugcucug cauguuacau aagauaaaug ugcugaaugg     1080

uuuucaaaua aaaaugaggu acucuccugg aaauauuaag aaagacuauc uaaauguuga     1140

aagaucaaaa gguuaauaaa guaauuauaa cu                                   1172


<210>  60
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  61
<211>  995
<212>  RNA
<213>  Homo sapiens

<400>  61
gaauucggcc aaagaggccu acuuccaaga agagcagcaa agcugaagua gcagcaacag       60

caccagcagc aacagcaaaa aacaaacaug agugugaagg gcauggcuau agccuuggcu      120

gugauauugu gugcuacagu uguucaaggc uuccccaugu ucaaaagagg acgcugucuu      180

ugcauaggcc cugggguaaa agcagugaaa guggcagaua uugagaaagc cuccauaaug      240

uacccaagua acaacuguga caaaauagaa gugauuauua cccugaaaga aaauaaagga      300

caacgaugcc uaaaucccaa aucgaagcaa gcaaggcuua uaaucaaaaa aguugaaaga      360

aagaauuuuu aaaaauauca aaacauauga aguccuggaa aagggcaucu gaaaaaccua      420

gaacaaguuu aacugugacu acugaaauga caagaauucu acaguaggaa acugagacuu      480

uucuaugguu uugugacuuu caacuuuugu acaguuaugu gaaggaugaa agguggguga      540

aaggaccaaa aacagaaaua cagucuuccu gaaugaauga caaucagaau uccacugccc      600

aaaggagucc aacaauuaaa uggauuucua ggaaaagcua ccuuaagaaa ggcugguuac      660

caucggaguu uacaaagugc uuucacguuc uuacuuguug uauuauacau ucaugcauuu      720

cuaggcuaga gaaccuucua gauuugaugc uuacaacuau ucuguuguga cuaugagaac      780

auuucugucu cuagaaguua ucugucugua uugaucuuua ugcuauauua cuaucugugg      840

uuacagugga gacauugaca uuauuacugg agucaagccc uuauaaguca aaagcaccua      900

ugugucguaa agcauuccuc aaacauuuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaagcg gccgc                                 995


<210>  62
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10  


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  69
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  70
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  71
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  72
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  74
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  75
<211>  2502
<212>  RNA
<213>  Homo sapiens

<400>  75
uauucaucaa gugcccucua gcuguuaagu cacucugauc ucugacugca gcuccuacug       60

uuggacacac cuggccggug cuucaguuag aucaaaccau ugcugaaacu gaagaggaca      120

ugucaaauau uacagaucca cagauguggg auuuugauga ucuaaauuuc acuggcaugc      180

caccugcaga ugaagauuac agccccugua ugcuagaaac ugagacacuc aacaaguaug      240

uugugaucau cgccuaugcc cuaguguucc ugcugagccu gcugggaaac ucccugguga      300

ugcuggucau cuuauacagc agggucggcc gcuccgucac ugaugucuac cugcugaacc      360

uggccuuggc cgaccuacuc uuugcccuga ccuugcccau cugggccgcc uccaagguga      420

auggcuggau uuuuggcaca uuccugugca agguggucuc acuccugaag gaagucaacu      480

ucuacagugg cauccugcug uuggccugca ucagugugga ccguuaccug gccauugucc      540

augccacacg cacacugacc cagaagcguc acuuggucaa guuuguuugu cuuggcugcu      600

ggggacuguc uaugaaucug ucccugcccu ucuuccuuuu ccgccaggcu uaccauccaa      660

acaauuccag uccaguuugc uaugaggucc ugggaaauga cacagcaaaa uggcggaugg      720

uguugcggau ccugccucac accuuuggcu ucaucgugcc gcuguuuguc augcuguucu      780

gcuauggauu cacccugcgu acacuguuua aggcccacau ggggcagaag caccgagcca      840

ugagggucau cuuugcuguc guccucaucu uccugcuuug cuggcugccc uacaaccugg      900

uccugcuggc agacacccuc augaggaccc aggugaucca ggagagcugu gagcgccgca      960

acaacaucgg ccgggcccug gaugccacug agauucuggg auuucuccau agcugccuca     1020

accccaucau cuacgccuuc aucggccaaa auuuucgcca uggauuccuc aagauccugg     1080

cuaugcaugg ccuggucagc aaggaguucu uggcacguca ucguguuacc uccuacacuu     1140

cuucgucugu caaugucucu uccaaccucu gaaaaccauc gaugaaggaa uaucucuucu     1200

cagaaggaaa gaauaaccaa cacccugagg uugugugugg aaggugaucu ggcucuggac     1260

aggcacuauc uggguuuugg ggggacgcua uaggaugugg ggaaguuagg aacugguguc     1320

uucaggggcc acaccaaccu ucugaggagc uguugaggua ccuccaagga ccggccuuug     1380

caccuccaug gaaacgaagc accaucauuc ccguugaacg ucacaucuuu aacccacuaa     1440

cuggcuaauu agcauggcca caucugagcc ccgaaucuga cauuagauga gagaacaggg     1500

cugaagcugu guccucauga gggcuggaug cucucguuga cccucacagg agcaucuccu     1560

caacucugag uguuaagcgu ugagccacca agcugguggc ucugugugcu cugauccgag     1620

cucagggggg ugguuuuccc aucucaggug uguugcagug ucugcuggag acauugaggc     1680

aggcacugcc aaaacaucaa ccugccagcu ggccuuguga ggagcuggaa acacauguuc     1740

cccuuggggg ugguggauga acaaagagaa agaggguuug gaagccagau cuaugccaca     1800

agaacccccu uuacccccau gaccaacauc gcagacacau gugcuggcca ccugcugagc     1860

cccaagugga acgagacaag cagcccuuag cccuuccccu cugcagcuuc caggcuggcg     1920

ugcagcauca gcaucccuag aaagccaugu gcagccacca guccauuggg caggcagaug     1980

uuccuaauaa agcuucuguu ccgugcuugu cccuguggaa guaucuuggu ugugacagag     2040

ucaagggugu gugcagcauu guuggcuguu ccugcaguag aaugggggca gcaccuccua     2100

agaaggcacc ucucuggguu gaagggcagu guucccuggg gcuuuaacuc cugcuagaac     2160

agucucuuga ggcacagaaa cuccuguuca ugcccauacc ccuggccaag gaagaucccu     2220

uuguccacaa guaaaaggaa augcuccucc agggagucuc agcuucaccc ugaggugagc     2280

aucaucuucu ggguuaggcc uugccuaggc auagcccugc cucaagcuau gugagcucac     2340

cagucccucc ccaaaugcuu uccaugaguu gcaguuuuuu ccuagucugu uuucccuccu     2400

uggagacagg gcccugucgg uuuauucacu guauguccuu ggugccugga gccuacuaaa     2460

ugcucaauaa auaaugauca caggaaaaaa aaaaaaaaaa aa                        2502


<210>  76
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  77
<211>  2880
<212>  RNA
<213>  Homo sapiens

<400>  77
agguucaaaa cauucagaga cagaaggugg auagacaaau cuccaccuuc agacugguag       60

gcuccuccag aagccaucag acaggaagau gugaaaaucc ccagcacuca ucccagaauc      120

acuaaguggc accuguccug ggccaaaguc ccaggacaga ccucauuguu ccucuguggg      180

aauaccuccc caggagggca uccuggauuu cccccuugca acccagguca gaaguuucau      240

cgucaagguu guuucaucuu uuuuuuccug ucuaacagcu cugacuacca cccaaccuug      300

aggcacagug aagacaucgg uggccacucc aauaacagca ggucacagcu gcucuucugg      360

agguguccua caggugaaaa gcccagcgac ccagucagga uuuaaguuua ccucaaaaau      420

ggaagauuuu aacauggaga gugacagcuu ugaagauuuc uggaaaggug aagaucuuag      480

uaauuacagu uacagcucua cccugccccc uuuucuacua gaugccgccc caugugaacc      540

agaaucccug gaaaucaaca aguauuuugu ggucauuauc uaugcccugg uauuccugcu      600

gagccugcug ggaaacuccc ucgugaugcu ggucaucuua uacagcaggg ucggccgcuc      660

cgucacugau gucuaccugc ugaaccuagc cuuggccgac cuacucuuug cccugaccuu      720

gcccaucugg gccgccucca aggugaaugg cuggauuuuu ggcacauucc ugugcaaggu      780

ggucucacuc cugaaggaag ucaacuucua uaguggcauc cugcuacugg ccugcaucag      840

uguggaccgu uaccuggcca uuguccaugc cacacgcaca cugacccaga agcgcuacuu      900

ggucaaauuc auaugucuca gcaucugggg ucuguccuug cuccuggccc ugccugucuu      960

acuuuuccga aggaccgucu acucauccaa uguuagccca gccugcuaug aggacauggg     1020

caacaauaca gcaaacuggc ggaugcuguu acggauccug ccccaguccu uuggcuucau     1080

cgugccacug cugaucaugc uguucugcua cggauucacc cugcguacgc uguuuaaggc     1140

ccacaugggg cagaagcacc gggccaugcg ggucaucuuu gcugucgucc ucaucuuccu     1200

gcucugcugg cugcccuaca accugguccu gcuggcagac acccucauga ggacccaggu     1260

gauccaggag accugugagc gccgcaauca caucgaccgg gcucuggaug ccaccgagau     1320

ucugggcauc cuucacagcu gccucaaccc ccucaucuac gccuucauug gccagaaguu     1380

ucgccaugga cuccucaaga uucuagcuau acauggcuug aucagcaagg acucccugcc     1440

caaagacagc aggccuuccu uuguuggcuc uucuucaggg cacacuucca cuacucucua     1500

agaccuccug ccuaagugca gccccguggg guuccucccu ucucuucaca gucacauucc     1560

aagccucaug uccacugguu cuucuugguc ucagugucaa ugcagccccc auugugguca     1620

caggaaguag aggaggccac guucuuacua guuucccuug caugguuuag aaagcuugcc     1680

cuggugccuc accccuugcc auaauuacua ugucauuugc uggagcucug cccauccugc     1740

cccugagccc auggcacucu auguucuaag aagugaaaau cuacacucca gugagacagc     1800

ucugcauacu cauuaggaug gcuaguauca aaagaaagaa aaucaggcug gccaacgggg     1860

ugaaacccug ucucuacuaa aaauacaaaa aaaaaaaaaa auuagccggg cgugguggug     1920

agugccugua aucacagcua cuugggaggc ugagauggga gaaucacuug aacccgggag     1980

gcagagguug cagugagccg agauugugcc ccugcacucc agccugagcg acagugagac     2040

ucugucucag uccaugaaga uguagaggag aaacuggaac ucucgagcgu ugcugggggg     2100

gauuguaaaa uggugugacc acugcagaag acaguauggc agcuuuccuc aaaacuucag     2160

acauagaauu aacacaugau ccugcaauuc cacuuauagg aauugaccca caagaaauga     2220

aagcagggac uugaacccau auuuguacac caauauucau agcagcuuau ucacaagacc     2280

caaaaggcag aagcaaccca aauguucauc aaugaaugaa ugaauggcua agcaaaaugu     2340

gauauguacc uaacgaagua uccuucagcc ugaaagagga augaaguacu cauacauguu     2400

acaacacgga cgaaccuuga aaacuuuaug cuaagugaaa uaagccagac aucaacagau     2460

aaauaguuua ugauuccacc uacaugaggu acugagagug aacaaauuua cagagacaga     2520

aagcagaaca gugauuacca gggacugagg ggaggggagc augggaagug acgguuuaau     2580

gggcacaggg uuuauguuua ggauguugaa aaaguucugc agauaaacag uagugauagu     2640

uguaccgcaa ugugacuuaa ugccacuaaa uugacacuua aaaaugguuu aaauggucaa     2700

uuuuguuaug uauauuuuau aucaauuuaa aaaaaaaccu gagccccaaa agguauuuua     2760

aucaccaagg cugauuaaac caaggcuaga accaccugcc uauauuuuuu guuaaaugau     2820

uucauucaau aucuuuuuuu uaauaaacca uuuuuacuug gguguuuaua aaaaaaaaaa     2880


<210>  78
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  79
<211>  532
<212>  RNA
<213>  Homo sapiens

<400>  79
gagaaaccag agacuguagc aacucuggca gggagaagcu gucucugaug gccugaagcu       60

gugggcagcu ggccaagccu aaccgcuaua aaaaggagcu gccucucagc ccugcauguc      120

ucuugucagc ugucuuucag aagaccuggu ggggcaaguc cgugggcauc auguugaccg      180

agcuggagaa agccuugaac ucuaucaucg acgucuacca caaguacucc cugauaaagg      240

ggaauuucca ugccgucuac agggaugacc ugaagaaauu gcuagagacc gaguguccuc      300

aguauaucag gaaaaagggu gcagacgucu gguucaaaga guuggauauc aacacugaug      360

gugcaguuaa cuuccaggag uuccucauuc uggugauaaa gaugggcgug gcagcccaca      420

aaaaaagcca ugaagaaagc cacaaagagu agcugaguua cugggcccag aggcugggcc      480

ccuggacaug uaccugcaga auaauaaagu caucaauacc ucaaaaaaaa aa              532


<210>  80
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  81
<211>  586
<212>  RNA
<213>  Homo sapiens

<400>  81
aaacacucug uguggcuccu cggcuuugac agagugcaag acgaugacuu gcaaaauguc       60

gcagcuggaa cgcaacauag agaccaucau caacaccuuc caccaauacu cugugaagcu      120

ggggcaccca gacacccuga accaggggga auucaaagag cuggugcgaa aagaucugca      180

aaauuuucuc aagaaggaga auaagaauga aaaggucaua gaacacauca uggaggaccu      240

ggacacaaau gcagacaagc agcugagcuu cgaggaguuc aucaugcuga uggcgaggcu      300

aaccugggcc ucccacgaga agaugcacga gggugacgag ggcccuggcc accaccauaa      360

gccaggccuc ggggagggca cccccuaaga ccacaguggc caagaucaca guggccacgg      420

ccacggccac agucauggug gccacggcca cagccacuaa ucaggaggcc aggccacccu      480

gccucuaccc aaccagggcc ccggggccug uuaugucaaa cugucuuggc uguggggcua      540

ggggcugggg ccaaauaaag ucucuuccuc caagucaaaa aaaaaa                     586


<210>  82
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


