                         SEQUENCE LISTING

<110>  Merrimack Pharmaceuticals, Inc.
 
<120>  EPHA2-TARGETED DOCETAXEL -GENERATING LIPOSOMES IN COMBINATION 
       WITH AN AGENT THAT IMPEDES REGULATORY T CELL ACTIVITY FOR 
       TREATING CANCER

<130>  239669-427728

<150>  62465750
<151>  2017-03-01

<150>  62479571
<151>  2017-03-21

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  2

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr 
1               5                   10                  


<210>  3
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  3

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  4

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  5

Ser Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys 
            20          


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  6

Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  7
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  7

Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Thr Ser Ala Ser 
1               5                   10                  15      


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  8

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  9
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  9
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gaccgtgatt agcccgaccg gcgcgaacac ctattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  10

Ser Tyr Ala Met His 
1               5   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  11

Val Ile Ser Pro Ala Gly Asn Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  12

Val Ile Ser Pro Ala Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  13

Val Ile Ser Pro Asp Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  14

Val Ile Ser Pro His Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  15

Val Ile Ser Arg Arg Gly Asp Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  16

Val Ile Ser Asn Asn Gly His Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  17

Val Ile Ser Pro Ala Gly Pro Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  18

Val Ile Ser Pro Ser Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  19

Val Ile Ser Pro Asn Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  20

Ala Ile Ser Pro Pro Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  21

Val Ile Ser Pro Thr Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  22

Val Ile Ser Pro His Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  23

Val Ile Ser Asn Asn Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  24

Val Ile Ser Pro Ala Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  25

Val Ile Ser Pro Pro Gly His Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  26

Val Ile Ser His Asp Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  27

Val Ile Ser Arg His Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  28

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  29

Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  30

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  31

Gly Glu Asn Asn Arg Pro Ser 
1               5           


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  32
astggggsgg ggsggggsgg ggs                                               23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  33
ggggsggggs ggggsggggs                                                   20


<210>  34
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  34
ggggsggggs ggggs                                                        15


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  35
astggggagg ggaggggagg gga                                               23


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  36
ggggagggga ggggagggga                                                   20


<210>  37
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  37

Thr Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro Thr 
1               5                   10                  15      


Ala Asn Ser Gly Thr Ser Gly Ser 
            20                  


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  38

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  39

Asn Ser Arg Asp Ser Ser Gly Thr His Leu Thr Val 
1               5                   10          


<210>  40
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  41
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
145                 150                 155                 160 


Val Ser Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  42
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  42
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgc agcagtccgg agggggagtg gtgcagccgg gacggtcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggat tggaatgggt ggcagtgatt agctacgacg gctcgaacaa gtactacgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaacca tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaagatccg gccgtgtccg tggcgctggg gcagactgtc      540

tccatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggacagg ctcctctgct cgtgatctac ggcgaaaaca atcggccatc gggaatccct      660

gaccgcttta gcggttcgag ctccggaaac actgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  43
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  43
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggat tggaatgggt ggcagtgatt agctacgacg gctcgaacaa gtactacgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  44
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ala Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  45
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  45
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gagcgtgatt agcccggcgg gccgcaacaa atattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  46
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Pro Asp Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  47
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  47
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gaccgtgatt agcccggatg gccataacac ctattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtcgta cggtggcggc gcccagtcac      840

catcatcatc accactgata a                                                861


<210>  48
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Pro Ser Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  49
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  49
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gaccgtgatt agcccgagcg gccataacac ctattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  50
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Pro Asn Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  51
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  51
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gaccgtgatt agcccgaacg gccataacac ctattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggtggcg gcagcggcgg ctgctgataa      840


<210>  52
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Pro Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


<210>  53
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  53
atgggctggt ctctgatcct gctgttcctg gtggccgtgg ccacgcgtgt gctctcgcaa       60

gtgcagctgg tgcagtccgg agggggactg gtgcagccgg gaggctcact cagactgtcc      120

tgcgccgctt cgggcttcac tttctcctcg tacgctatgc attgggtccg ccaagccccc      180

ggaaagggac tggaatgggt gagcgcgatt agcccgccgg gccataacac ctattatgcg      240

gacagcgtca aaggcagatt caccattagc cgagataaca gcaagaatac cctgtacctc      300

caaatgaata gcctcagggc cgaggacacg gctgtgtact actgcgcacg cgcgtcagtc      360

ggcgcaacgg gtccattcga catctgggga cagggaaccc tggtcaccgt gtcatcggca      420

tcgactggag ggggaggctc tggaggaggg ggatcgggtg gcggagggtc gggcggagga      480

ggctcatcat ccgagttgac ccaacccccg tccgtgtccg tggccccggg gcagactgtc      540

actatcactt gccaaggaga ctcactgcgc tcctactacg cctcgtggta tcagcagaaa      600

ccgggaaccg ctcctaaact cctgatctac ggcgaaaaca atcggccatc gggagtgcct      660

gaccgcttta gcggttcgag ctccggaact tctgcgagcc tgaccatcac tggtgcccaa      720

gccgaggatg aagcggacta ctactgcaac tcgcgggatt cctccgggac ccacctgacc      780

gtgttcggcg ggggaactaa gctgaccgtg ctgggt                                816


<210>  54
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically Generated Sequence

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Ser Pro Thr Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Val Gly Ala Thr Gly Pro Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
    130                 135                 140                 


Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Glu Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Leu 
225                 230                 235                 240 


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Cys 
            


