                               SEQUENCE LISTING



<110> GENENTECH, INC.

      F. HOFFMANN-LA ROCHE AG 

 

<120> ADJUVANT TREATMENT OF HER2-POSITIVE BREAST CANCER 



<130> P34141-WO 

	

<140>

<141>



<150> 62/486,876

<151> 2017-04-18



<150> 62/469,317

<151> 2017-03-09



<150> 62/466,239

<151> 2017-03-02



<160> 22    



<170> PatentIn version 3.5



<210> 1

<211> 195

<212> PRT

<213> Homo sapiens



<400> 1

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 

1               5                   10                  15      





Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 

            20                  25                  30          





Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 

        35                  40                  45              





Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 

    50                  55                  60                  





Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 

65                  70                  75                  80  





Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 

                85                  90                  95      





Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 

            100                 105                 110         





Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 

        115                 120                 125             





Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 

    130                 135                 140                 





Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 

145                 150                 155                 160 





Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 

                165                 170                 175     





Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 

            180                 185                 190         





Leu Thr Arg 

        195 





<210> 2

<211> 124

<212> PRT

<213> Homo sapiens



<400> 2

Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr 

1               5                   10                  15      





Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His 

            20                  25                  30          





Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu 

        35                  40                  45              





Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser 

    50                  55                  60                  





Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr 

65                  70                  75                  80  





Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu 

                85                  90                  95      





Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln 

            100                 105                 110         





Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val 

        115                 120                 





<210> 3

<211> 169

<212> PRT

<213> Homo sapiens



<400> 3

Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr 

1               5                   10                  15      





Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 

            20                  25                  30          





Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr 

        35                  40                  45              





Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 

    50                  55                  60                  





Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp 

65                  70                  75                  80  





Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His 

                85                  90                  95      





Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu 

            100                 105                 110         





Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 

        115                 120                 125             





His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 

    130                 135                 140                 





Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu 

145                 150                 155                 160 





Asp Glu Cys Val Gly Glu Gly Leu Ala 

                165                 





<210> 4

<211> 142

<212> PRT

<213> Homo sapiens



<400> 4

Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 

1               5                   10                  15      





Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 

            20                  25                  30          





Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 

        35                  40                  45              





His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 

    50                  55                  60                  





Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 

65                  70                  75                  80  





Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 

                85                  90                  95      





Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 

            100                 105                 110         





Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 

        115                 120                 125             





Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr 

    130                 135                 140         





<210> 5

<211> 107

<212> PRT

<213> Mus musculus



<400> 5

Asp Thr Val Met Thr Gln Ser His Lys Ile Met Ser Thr Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 

65                  70                  75                  80  





Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 

                85                  90                  95      





Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105         





<210> 6

<211> 119

<212> PRT

<213> Mus musculus



<400> 6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 

1               5                   10                  15      





Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 

            20                  25                  30          





Thr Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 

        35                  40                  45              





Gly Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 

    50                  55                  60                  





Lys Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Arg Ile Val Tyr 

65                  70                  75                  80  





Met Glu Leu Arg Ser Leu Thr Phe Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Thr Leu Thr Val Ser Ser 

        115                 





<210> 7

<211> 107

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 

65                  70                  75                  80  





Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 

                85                  90                  95      





Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 

            100                 105         





<210> 8

<211> 119

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 

            20                  25                  30          





Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 

    50                  55                  60                  





Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser 

        115                 





<210> 9

<211> 107

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 

            20                  25                  30          





Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 

65                  70                  75                  80  





Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Leu Pro Trp 

                85                  90                  95      





Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 

            100                 105         





<210> 10

<211> 119

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Gly Arg Val Gly Tyr Ser Leu Tyr Asp Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser 

        115                 





<210> 11

<211> 214

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 

65                  70                  75                  80  





Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 

                85                  90                  95      





Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 

            100                 105                 110         





Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 

        115                 120                 125             





Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 

    130                 135                 140                 





Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 

145                 150                 155                 160 





Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 

                165                 170                 175     





Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 

            180                 185                 190         





Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 

        195                 200                 205             





Phe Asn Arg Gly Glu Cys 

    210                 





<210> 12

<211> 448

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 

            20                  25                  30          





Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 

    50                  55                  60                  





Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 

        115                 120                 125             





Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 

    130                 135                 140                 





Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 

145                 150                 155                 160 





Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 

                165                 170                 175     





Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 

            180                 185                 190         





Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 

        195                 200                 205             





Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 

    210                 215                 220                 





Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 

225                 230                 235                 240 





Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 

                245                 250                 255     





Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 

            260                 265                 270         





Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 

        275                 280                 285             





Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 

    290                 295                 300                 





Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 

305                 310                 315                 320 





Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 

                325                 330                 335     





Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 

            340                 345                 350         





Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 

        355                 360                 365             





Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 

    370                 375                 380                 





Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 

385                 390                 395                 400 





Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 

                405                 410                 415     





Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 

            420                 425                 430         





Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 

        435                 440                 445             





<210> 13

<211> 214

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 

    50                  55                  60                  





Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 

65                  70                  75                  80  





Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 

                85                  90                  95      





Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 

            100                 105                 110         





Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 

        115                 120                 125             





Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 

    130                 135                 140                 





Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 

145                 150                 155                 160 





Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 

                165                 170                 175     





Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 

            180                 185                 190         





Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 

        195                 200                 205             





Phe Asn Arg Gly Glu Cys 

    210                 





<210> 14

<211> 449

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 

            20                  25                  30          





Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 

            100                 105                 110         





Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 

        115                 120                 125             





Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 

    130                 135                 140                 





Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 

145                 150                 155                 160 





Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 

                165                 170                 175     





Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 

            180                 185                 190         





Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 

        195                 200                 205             





Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 

    210                 215                 220                 





Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 

225                 230                 235                 240 





Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 

                245                 250                 255     





Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 

            260                 265                 270         





Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 

        275                 280                 285             





Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 

    290                 295                 300                 





Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 

305                 310                 315                 320 





Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 

                325                 330                 335     





Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 

            340                 345                 350         





Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 

        355                 360                 365             





Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 

    370                 375                 380                 





Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 

385                 390                 395                 400 





Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 

                405                 410                 415     





Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 

            420                 425                 430         





Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 

        435                 440                 445             





Gly 

    





<210> 15

<211> 217

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 15

Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 

1               5                   10                  15      





Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 

            20                  25                  30          





Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 

        35                  40                  45              





Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 

    50                  55                  60                  





Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 

65                  70                  75                  80  





Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile 

                85                  90                  95      





Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 

            100                 105                 110         





Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 

        115                 120                 125             





Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 

    130                 135                 140                 





Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 

145                 150                 155                 160 





Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 

                165                 170                 175     





Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 

            180                 185                 190         





Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 

        195                 200                 205             





Thr Lys Ser Phe Asn Arg Gly Glu Cys 

    210                 215         





<210> 16

<211> 449

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 

1               5                   10                  15      





Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 

            20                  25                  30          





Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              





Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 

    50                  55                  60                  





Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 

        115                 120                 125             





Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 

    130                 135                 140                 





Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 

145                 150                 155                 160 





Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 

                165                 170                 175     





Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 

            180                 185                 190         





Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 

        195                 200                 205             





Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 

    210                 215                 220                 





Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 

225                 230                 235                 240 





Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 

                245                 250                 255     





Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 

            260                 265                 270         





Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 

        275                 280                 285             





Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 

    290                 295                 300                 





Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 

305                 310                 315                 320 





Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 

                325                 330                 335     





Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 

            340                 345                 350         





Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 

        355                 360                 365             





Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 

    370                 375                 380                 





Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 

385                 390                 395                 400 





Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 

                405                 410                 415     





Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 

            420                 425                 430         





Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 

        435                 440                 445             





Lys 

    





<210> 17

<211> 10

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"





<220>

<221> VARIANT

<222> (10)..(10)

<223> /replace="Ser"



<220>

<221> MISC_FEATURE

<222> (10)..(10)

<223> /note=" Residue given in the sequence has no preference 

      with respect to that in the annotations for said position "



<400> 17

Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp 

1               5                   10  





<210> 18

<211> 17

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"



<400> 18

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 

1               5                   10                  15      





Gly 

    





<210> 19

<211> 10

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"



<400> 19

Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 

1               5                   10  





<210> 20

<211> 11

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"



<400> 20

Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala 

1               5                   10      





<210> 21

<211> 7

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"





<220>

<221> VARIANT

<222> (5)..(5)

<223> /replace="Leu"



<220>

<221> VARIANT

<222> (6)..(6)

<223> /replace="Glu"



<220>

<221> VARIANT

<222> (7)..(7)

<223> /replace="Ser"



<220>

<221> MISC_FEATURE

<222> (5)..(7)

<223> /note="Residue given in the sequence has no preference 

      with respect to that in the annotations for said position "



<400> 21

Ser Ala Ser Tyr Arg Tyr Thr 

1               5           





<210> 22

<211> 9

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      peptide"



<400> 22

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 

1               5                   





