                         SEQUENCE LISTING

<110>  Epizyme, Inc.
 
<120>  Inhibition of SMARCA2 for Treatment of Cancer

<130>  EPIZ-077/001WO

<140>  PCT/US2018/020124
<141>  2018-02-28  

<150>  62/464,811
<151>  2017-02-28

<150>  62,542,241
<151>  2017-08-07

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5879
<212>  DNA
<213>  Homo sapiens

<400>  1
tcagaagaaa gccccgagat cacagagacc cggcgagatc acagagaccc ggcctgaagg       60

aacgtggaaa gaccaatgta cctgttttga ccggttgcct ggagcaagaa gttccagttg      120

gggagaattt tcagaagata aagtcggaga ttgtggaaag acttgacttg cagcattact      180

ctactgactg gcagagacag gagaggtaga tgtccacgcc cacagaccct ggtgcgatgc      240

cccacccagg gccttcgccg gggcctgggc cttcccctgg gccaattctt gggcctagtc      300

caggaccagg accatcccca ggttccgtcc acagcatgat ggggccaagt cctggacctc      360

caagtgtctc ccatcctatg ccgacgatgg ggtccacaga cttcccacag gaaggcatgc      420

atcaaatgca taagcccatc gatggtatac atgacaaggg gattgtagaa gacatccatt      480

gtggatccat gaagggcact ggtatgcgac cacctcaccc aggcatgggc cctccccaga      540

gtccaatgga tcaacacagc caaggttata tgtcaccaca cccatctcca ttaggagccc      600

cagagcacgt ctccagccct atgtctggag gaggcccaac tccacctcag atgccaccaa      660

gccagccggg ggccctcatc ccaggtgatc cgcaggccat gagccagccc aacagaggtc      720

cctcaccttt cagtcctgtc cagctgcatc agcttcgagc tcagatttta gcttataaaa      780

tgctggcccg aggccagccc ctccccgaaa cgctgcagct tgcagtccag gggaaaagga      840

cgttgcctgg cttgcagcaa caacagcagc agcaacagca gcagcagcag cagcagcagc      900

agcagcagca gcagcaacag cagccgcagc agcagccgcc gcaaccacag acgcagcaac      960

aacagcagcc ggcccttgtt aactacaaca gaccatctgg cccggggccg gagctgagcg     1020

gcccgagcac cccgcagaag ctgccggtgc ccgcgcccgg cggccggccc tcgcccgcgc     1080

cccccgcagc cgcgcagccg cccgcggccg cagtgcccgg gccctcagtg ccgcagccgg     1140

ccccggggca gccctcgccc gtcctccagc tgcagcagaa gcagagccgc atcagcccca     1200

tccagaaacc gcaaggcctg gaccccgtgg aaattctgca agagcgggaa tacagacttc     1260

aggcccgcat agctcatagg atacaagaac tggaaaatct gcctggctct ttgccaccag     1320

atttaagaac caaagcaacc gtggaactaa aagcacttcg gttactcaat ttccagcgtc     1380

agctgagaca ggaggtggtg gcctgcatgc gcagggacac gaccctggag acggctctca     1440

actccaaagc atacaaacgg agcaagcgcc agactctgag agaagctcgc atgaccgaga     1500

agctggagaa gcagcagaag attgagcagg agaggaaacg ccgtcagaaa caccaggaat     1560

acctgaacag tattttgcaa catgcaaaag attttaagga atatcatcgg tctgtggccg     1620

gaaagatcca gaagctctcc aaagcagtgg caacttggca tgccaacact gaaagagagc     1680

agaagaagga gacagagcgg attgaaaagg agagaatgcg gcgactgatg gctgaagatg     1740

aggagggtta tagaaaactg attgatcaaa agaaagacag gcgtttagct taccttttgc     1800

agcagaccga tgagtatgta gccaatctga ccaatctggt ttgggagcac aagcaagccc     1860

aggcagccaa agagaagaag aagaggagga ggaggaagaa gaaggctgag gagaatgcag     1920

agggtgggga gtctgccctg ggaccggatg gagagcccat agatgagagc agccagatga     1980

gtgacctccc tgtcaaagtg actcacacag aaaccggcaa ggttctgttc ggaccagaag     2040

cacccaaagc aagtcagctg gacgcctggc tggaaatgaa tcctggttat gaagttgccc     2100

ctagatctga cagtgaagag agtgattctg attatgagga agaggatgag gaagaagagt     2160

ccagtaggca ggaaaccgaa gagaaaatac tcctggatcc aaatagcgaa gaagtttctg     2220

agaaggatgc taagcagatc attgagacag ctaagcaaga cgtggatgat gaatacagca     2280

tgcagtacag tgccaggggc tcccagtcct actacaccgt ggctcatgcc atctcggaga     2340

gggtggagaa acagtctgcc ctcctaatta atgggaccct aaagcattac cagctccagg     2400

gcctggaatg gatggtttcc ctgtataata acaacttgaa cggaatctta gccgatgaaa     2460

tggggcttgg aaagaccata cagaccattg cactcatcac ttatctgatg gagcacaaaa     2520

gactcaatgg cccctatctc atcattgttc ccctttcgac tctatctaac tggacatatg     2580

aatttgacaa atgggctcct tctgtggtga agatttctta caagggtact cctgccatgc     2640

gtcgctccct tgtcccccag ctacggagtg gcaaattcaa tgtcctcttg actacttatg     2700

agtatattat aaaagacaag cacattcttg caaagattcg gtggaaatac atgatagtgg     2760

acgaaggcca ccgaatgaag aatcaccact gcaagctgac tcaggtcttg aacactcact     2820

atgtggcccc cagaaggatc ctcttgactg ggaccccgct gcagaataag ctccctgaac     2880

tctgggccct cctcaacttc ctcctcccaa caatttttaa gagctgcagc acatttgaac     2940

aatggttcaa tgctccattt gccatgactg gtgaaagggt ggacttaaat gaagaagaaa     3000

ctatattgat catcaggcgt ctacataagg tgttaagacc atttttacta aggagactga     3060

agaaagaagt tgaatcccag cttcccgaaa aagtggaata tgtgatcaag tgtgacatgt     3120

cagctctgca gaagattctg tatcgccata tgcaagccaa ggggatcctt ctcacagatg     3180

gttctgagaa agataagaag gggaaaggag gtgctaagac acttatgaac actattatgc     3240

agttgagaaa aatctgcaac cacccatata tgtttcagca cattgaggaa tcctttgctg     3300

aacacctagg ctattcaaat ggggtcatca atggggctga actgtatcgg gcctcaggga     3360

agtttgagct gcttgatcgt attctgccaa aattgagagc gactaatcac cgagtgctgc     3420

ttttctgcca gatgacatct ctcatgacca tcatggagga ttattttgct tttcggaact     3480

tcctttacct acgccttgat ggcaccacca agtctgaaga tcgtgctgct ttgctgaaga     3540

aattcaatga acctggatcc cagtatttca ttttcttgct gagcacaaga gctggtggcc     3600

tgggcttaaa tcttcaggca gctgatacag tggtcatctt tgacagcgac tggaatcctc     3660

atcaggatct gcaggcccaa gaccgagctc accgcatcgg gcagcagaac gaggtccggg     3720

tactgaggct ctgtaccgtg aacagcgtgg aggaaaagat cctcgcggcc gcaaaataca     3780

agctgaacgt ggatcagaaa gtgatccagg cgggcatgtt tgaccaaaag tcttcaagcc     3840

acgagcggag ggcattcctg caggccatct tggagcatga ggaggaaaat gaggaagaag     3900

atgaagtacc ggacgatgag actctgaacc aaatgattgc tcgacgagaa gaagaatttg     3960

acctttttat gcggatggac atggaccggc ggagggaaga tgcccggaac ccgaaacgga     4020

agccccgttt aatggaggag gatgagctgc cctcctggat cattaaggat gacgctgaag     4080

tagaaaggct cacctgtgaa gaagaggagg agaaaatatt tgggaggggg tcccgccagc     4140

gccgtgacgt ggactacagt gacgccctca cggagaagca gtggctaagg gccatcgaag     4200

acggcaattt ggaggaaatg gaagaggaag tacggcttaa gaagcgaaaa agacgaagaa     4260

atgtggataa agatcctgca aaagaagatg tggaaaaagc taagaagaga agaggccgcc     4320

ctcccgctga gaaactgtca ccaaatcccc ccaaactgac aaagcagatg aacgctatca     4380

tcgatactgt gataaactac aaagataggt gtaacgtgga gaaggtgccc agtaattctc     4440

agttggaaat agaaggaaac agttcagggc gacagctcag tgaagtcttc attcagttac     4500

cttcaaggaa agaattacca gaatactatg aattaattag gaagccagtg gatttcaaaa     4560

aaataaagga aaggattcgt aatcataagt accggagcct aggcgacctg gagaaggatg     4620

tcatgcttct ctgtcacaac gctcagacgt tcaacctgga gggatcccag atctatgaag     4680

actccatcgt cttacagtca gtgtttaaga gtgcccggca gaaaattgcc aaagaggaag     4740

agagtgagga tgaaagcaat gaagaggagg aagaggaaga tgaagaagag tcagagtccg     4800

aggcaaaatc agtcaaggtg aaaattaagc tcaataaaaa agatgacaaa ggccgggaca     4860

aagggaaagg caagaaaagg ccaaatcgag gaaaagccaa acctgtagtg agcgattttg     4920

acagcgatga ggagcaggat gaacgtgaac agtcagaagg aagtgggacg gatgatgagt     4980

gatcagtatg gacctttttc cttggtagaa ctgaattcct tcctcccctg tctcatttct     5040

acccagtgag ttcatttgtc atataggcac tgggttgttt ctatatcatc atcgtctata     5100

aactagcttt aggatagtgc cagacaaaca tatgatatca tggtgtaaaa aacacacaca     5160

tacacaaata tttgtaacat attgtgacca aatgggcctc aaagattcag attgaaacaa     5220

acaaaaagct tttgatggaa aatatgtggg tggatagtat atttctatgg gtgggtctaa     5280

tttggtaacg gtttgattgt gcctggtttt atcacctgtt cagatgagaa gatttttgtc     5340

ttttgtagca ctgataacca ggagaagcca ttaaaagcca ctggttattt tatttttcat     5400

caggcaattt tcgaggtttt tatttgttcg gtattgtttt tttacactgt ggtacatata     5460

agcaacttta ataggtgata aatgtacagt agttagattt cacctgcata tacatttttc     5520

cattttatgc tctatgatct gaacaaaagc tttttgaatt gtataagatt tatgtctact     5580

gtaaacattg cttaattttt ttgctcttga tttaaaaaaa agttttgttg aaagcgctat     5640

tgaatattgc aatctatata gtgtattgga tggcttcttt tgtcaccctg atctcctatg     5700

ttaccaatgt gtatcgtctc cttctcccta aagtgtactt aatctttgct ttctttgcac     5760

aatgtctttg gttgcaagtc ataagcctga ggcaaataaa attccagtaa tttcgaagaa     5820

tgtggtgttg gtgctttcct aataaagaaa taatttagct tgacaaaaaa aaaaaaaaa      5879


<210>  2
<211>  5838
<212>  DNA
<213>  Homo sapiens

<400>  2
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtc     2820

ttgaacactc actatgtggc ccccagaagg atcctcttga ctgggacccc gctgcagaat     2880

aagctccctg aactctgggc cctcctcaac ttcctcctcc caacaatttt taagagctgc     2940

agcacatttg aacaatggtt caatgctcca tttgccatga ctggtgaaag ggtggactta     3000

aatgaagaag aaactatatt gatcatcagg cgtctacata aggtgttaag accattttta     3060

ctaaggagac tgaagaaaga agttgaatcc cagcttcccg aaaaagtgga atatgtgatc     3120

aagtgtgaca tgtcagctct gcagaagatt ctgtatcgcc atatgcaagc caaggggatc     3180

cttctcacag atggttctga gaaagataag aaggggaaag gaggtgctaa gacacttatg     3240

aacactatta tgcagttgag aaaaatctgc aaccacccat atatgtttca gcacattgag     3300

gaatcctttg ctgaacacct aggctattca aatggggtca tcaatggggc tgaactgtat     3360

cgggcctcag ggaagtttga gctgcttgat cgtattctgc caaaattgag agcgactaat     3420

caccgagtgc tgcttttctg ccagatgaca tctctcatga ccatcatgga ggattatttt     3480

gcttttcgga acttccttta cctacgcctt gatggcacca ccaagtctga agatcgtgct     3540

gctttgctga agaaattcaa tgaacctgga tcccagtatt tcattttctt gctgagcaca     3600

agagctggtg gcctgggctt aaatcttcag gcagctgata cagtggtcat ctttgacagc     3660

gactggaatc ctcatcagga tctgcaggcc caagaccgag ctcaccgcat cgggcagcag     3720

aacgaggtcc gggtactgag gctctgtacc gtgaacagcg tggaggaaaa gatcctcgcg     3780

gccgcaaaat acaagctgaa cgtggatcag aaagtgatcc aggcgggcat gtttgaccaa     3840

aagtcttcaa gccacgagcg gagggcattc ctgcaggcca tcttggagca tgaggaggaa     3900

aatgaggaag aagatgaagt accggacgat gagactctga accaaatgat tgctcgacga     3960

gaagaagaat ttgacctttt tatgcggatg gacatggacc ggcggaggga agatgcccgg     4020

aacccgaaac ggaagccccg tttaatggag gaggatgagc tgccctcctg gatcattaag     4080

gatgacgctg aagtagaaag gctcacctgt gaagaagagg aggagaaaat atttgggagg     4140

gggtcccgcc agcgccgtga cgtggactac agtgacgccc tcacggagaa gcagtggcta     4200

agggccatcg aagacggcaa tttggaggaa atggaagagg aagtacggct taagaagcga     4260

aaaagacgaa gaaatgtgga taaagatcct gcaaaagaag atgtggaaaa agctaagaag     4320

agaagaggcc gccctcccgc tgagaaactg tcaccaaatc cccccaaact gacaaagcag     4380

atgaacgcta tcatcgatac tgtgataaac tacaaagata gttcagggcg acagctcagt     4440

gaagtcttca ttcagttacc ttcaaggaaa gaattaccag aatactatga attaattagg     4500

aagccagtgg atttcaaaaa aataaaggaa aggattcgta atcataagta ccggagccta     4560

ggcgacctgg agaaggatgt catgcttctc tgtcacaacg ctcagacgtt caacctggag     4620

ggatcccaga tctatgaaga ctccatcgtc ttacagtcag tgtttaagag tgcccggcag     4680

aaaattgcca aagaggaaga gagtgaggat gaaagcaatg aagaggagga agaggaagat     4740

gaagaagagt cagagtccga ggcaaaatca gtcaaggtga aaattaagct caataaaaaa     4800

gatgacaaag gccgggacaa agggaaaggc aagaaaaggc caaatcgagg aaaagccaaa     4860

cctgtagtga gcgattttga cagcgatgag gagcaggatg aacgtgaaca gtcagaagga     4920

agtgggacgg atgatgagtg atcagtatgg acctttttcc ttggtagaac tgaattcctt     4980

cctcccctgt ctcatttcta cccagtgagt tcatttgtca tataggcact gggttgtttc     5040

tatatcatca tcgtctataa actagcttta ggatagtgcc agacaaacat atgatatcat     5100

ggtgtaaaaa acacacacat acacaaatat ttgtaacata ttgtgaccaa atgggcctca     5160

aagattcaga ttgaaacaaa caaaaagctt ttgatggaaa atatgtgggt ggatagtata     5220

tttctatggg tgggtctaat ttggtaacgg tttgattgtg cctggtttta tcacctgttc     5280

agatgagaag atttttgtct tttgtagcac tgataaccag gagaagccat taaaagccac     5340

tggttatttt atttttcatc aggcaatttt cgaggttttt atttgttcgg tattgttttt     5400

ttacactgtg gtacatataa gcaactttaa taggtgataa atgtacagta gttagatttc     5460

acctgcatat acatttttcc attttatgct ctatgatctg aacaaaagct ttttgaattg     5520

tataagattt atgtctactg taaacattgc ttaatttttt tgctcttgat ttaaaaaaaa     5580

gttttgttga aagcgctatt gaatattgca atctatatag tgtattggat ggcttctttt     5640

gtcaccctga tctcctatgt taccaatgtg tatcgtctcc ttctccctaa agtgtactta     5700

atctttgctt tctttgcaca atgtctttgg ttgcaagtca taagcctgag gcaaataaaa     5760

ttccagtaat ttcgaagaat gtggtgttgg tgctttccta ataaagaaat aatttagctt     5820

gacaaaaaaa aaaaaaaa                                                   5838


<210>  3
<211>  5664
<212>  DNA
<213>  Homo sapiens

<400>  3
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtg     2820

gacttaaatg aagaagaaac tatattgatc atcaggcgtc tacataaggt gttaagacca     2880

tttttactaa ggagactgaa gaaagaagtt gaatcccagc ttcccgaaaa agtggaatat     2940

gtgatcaagt gtgacatgtc agctctgcag aagattctgt atcgccatat gcaagccaag     3000

gggatccttc tcacagatgg ttctgagaaa gataagaagg ggaaaggagg tgctaagaca     3060

cttatgaaca ctattatgca gttgagaaaa atctgcaacc acccatatat gtttcagcac     3120

attgaggaat cctttgctga acacctaggc tattcaaatg gggtcatcaa tggggctgaa     3180

ctgtatcggg cctcagggaa gtttgagctg cttgatcgta ttctgccaaa attgagagcg     3240

actaatcacc gagtgctgct tttctgccag atgacatctc tcatgaccat catggaggat     3300

tattttgctt ttcggaactt cctttaccta cgccttgatg gcaccaccaa gtctgaagat     3360

cgtgctgctt tgctgaagaa attcaatgaa cctggatccc agtatttcat tttcttgctg     3420

agcacaagag ctggtggcct gggcttaaat cttcaggcag ctgatacagt ggtcatcttt     3480

gacagcgact ggaatcctca tcaggatctg caggcccaag accgagctca ccgcatcggg     3540

cagcagaacg aggtccgggt actgaggctc tgtaccgtga acagcgtgga ggaaaagatc     3600

ctcgcggccg caaaatacaa gctgaacgtg gatcagaaag tgatccaggc gggcatgttt     3660

gaccaaaagt cttcaagcca cgagcggagg gcattcctgc aggccatctt ggagcatgag     3720

gaggaaaatg aggaagaaga tgaagtaccg gacgatgaga ctctgaacca aatgattgct     3780

cgacgagaag aagaatttga cctttttatg cggatggaca tggaccggcg gagggaagat     3840

gcccggaacc cgaaacggaa gccccgttta atggaggagg atgagctgcc ctcctggatc     3900

attaaggatg acgctgaagt agaaaggctc acctgtgaag aagaggagga gaaaatattt     3960

gggagggggt cccgccagcg ccgtgacgtg gactacagtg acgccctcac ggagaagcag     4020

tggctaaggg ccatcgaaga cggcaatttg gaggaaatgg aagaggaagt acggcttaag     4080

aagcgaaaaa gacgaagaaa tgtggataaa gatcctgcaa aagaagatgt ggaaaaagct     4140

aagaagagaa gaggccgccc tcccgctgag aaactgtcac caaatccccc caaactgaca     4200

aagcagatga acgctatcat cgatactgtg ataaactaca aagatagttc agggcgacag     4260

ctcagtgaag tcttcattca gttaccttca aggaaagaat taccagaata ctatgaatta     4320

attaggaagc cagtggattt caaaaaaata aaggaaagga ttcgtaatca taagtaccgg     4380

agcctaggcg acctggagaa ggatgtcatg cttctctgtc acaacgctca gacgttcaac     4440

ctggagggat cccagatcta tgaagactcc atcgtcttac agtcagtgtt taagagtgcc     4500

cggcagaaaa ttgccaaaga ggaagagagt gaggatgaaa gcaatgaaga ggaggaagag     4560

gaagatgaag aagagtcaga gtccgaggca aaatcagtca aggtgaaaat taagctcaat     4620

aaaaaagatg acaaaggccg ggacaaaggg aaaggcaaga aaaggccaaa tcgaggaaaa     4680

gccaaacctg tagtgagcga ttttgacagc gatgaggagc aggatgaacg tgaacagtca     4740

gaaggaagtg ggacggatga tgagtgatca gtatggacct ttttccttgg tagaactgaa     4800

ttccttcctc ccctgtctca tttctaccca gtgagttcat ttgtcatata ggcactgggt     4860

tgtttctata tcatcatcgt ctataaacta gctttaggat agtgccagac aaacatatga     4920

tatcatggtg taaaaaacac acacatacac aaatatttgt aacatattgt gaccaaatgg     4980

gcctcaaaga ttcagattga aacaaacaaa aagcttttga tggaaaatat gtgggtggat     5040

agtatatttc tatgggtggg tctaatttgg taacggtttg attgtgcctg gttttatcac     5100

ctgttcagat gagaagattt ttgtcttttg tagcactgat aaccaggaga agccattaaa     5160

agccactggt tattttattt ttcatcaggc aattttcgag gtttttattt gttcggtatt     5220

gtttttttac actgtggtac atataagcaa ctttaatagg tgataaatgt acagtagtta     5280

gatttcacct gcatatacat ttttccattt tatgctctat gatctgaaca aaagcttttt     5340

gaattgtata agatttatgt ctactgtaaa cattgcttaa tttttttgct cttgatttaa     5400

aaaaaagttt tgttgaaagc gctattgaat attgcaatct atatagtgta ttggatggct     5460

tcttttgtca ccctgatctc ctatgttacc aatgtgtatc gtctccttct ccctaaagtg     5520

tacttaatct ttgctttctt tgcacaatgt ctttggttgc aagtcataag cctgaggcaa     5580

ataaaattcc agtaatttcg aagaatgtgg tgttggtgct ttcctaataa agaaataatt     5640

tagcttgaca aaaaaaaaaa aaaa                                            5664


<210>  4
<211>  1846
<212>  DNA
<213>  Homo sapiens

<400>  4
cttggagagg cggaggtgga aacgatgcgc aggagttggc ttggggcttt ttgtttgcgt       60

gtccctgttt acctattcat aatcatggat cccctctgct ttgtgatact gtgaaccacg      120

cataacagca attctttaca ccaccgggtt gagaagaagg cgcctgaggc tgactttctg      180

gacctgccgt cacgcagtaa agatgtggtt ggccatcgaa gacggcaatt tggaggaaat      240

ggaagaggaa gtacggctta agaagcgaaa aagacgaaga aatgtggata aagatcctgc      300

aaaagaagat gtggaaaaag ctaagaagag aagaggccgc cctcccgctg agaaactgtc      360

accaaatccc cccaaactga caaagcagat gaacgctatc atcgatactg tgataaacta      420

caaagatagt tcagggcgac agctcagtga agtcttcatt cagttacctt caaggaaaga      480

attaccagaa tactatgaat taattaggaa gccagtggat ttcaaaaaaa taaaggaaag      540

gattcgtaat cataagtacc ggagcctagg cgacctggag aaggatgtca tgcttctctg      600

tcacaacgct cagacgttca acctggaggg atcccagatc tatgaagact ccatcgtctt      660

acagtcagtg tttaagagtg cccggcagaa aattgccaaa gaggaagaga gtgaggatga      720

aagcaatgaa gaggaggaag aggaagatga agaagagtca gagtccgagg caaaatcagt      780

caaggtgaaa attaagctca ataaaaaaga tgacaaaggc cgggacaaag ggaaaggcaa      840

gaaaaggcca aatcgaggaa aagccaaacc tgtagtgagc gattttgaca gcgatgagga      900

gcaggatgaa cgtgaacagt cagaaggaag tgggacggat gatgagtgat cagtatggac      960

ctttttcctt ggtagaactg aattccttcc tcccctgtct catttctacc cagtgagttc     1020

atttgtcata taggcactgg gttgtttcta tatcatcatc gtctataaac tagctttagg     1080

atagtgccag acaaacatat gatatcatgg tgtaaaaaac acacacatac acaaatattt     1140

gtaacatatt gtgaccaaat gggcctcaaa gattcagatt gaaacaaaca aaaagctttt     1200

gatggaaaat atgtgggtgg atagtatatt tctatgggtg ggtctaattt ggtaacggtt     1260

tgattgtgcc tggttttatc acctgttcag atgagaagat ttttgtcttt tgtagcactg     1320

ataaccagga gaagccatta aaagccactg gttattttat ttttcatcag gcaattttcg     1380

aggtttttat ttgttcggta ttgttttttt acactgtggt acatataagc aactttaata     1440

ggtgataaat gtacagtagt tagatttcac ctgcatatac atttttccat tttatgctct     1500

atgatctgaa caaaagcttt ttgaattgta taagatttat gtctactgta aacattgctt     1560

aatttttttg ctcttgattt aaaaaaaagt tttgttgaaa gcgctattga atattgcaat     1620

ctatatagtg tattggatgg cttcttttgt caccctgatc tcctatgtta ccaatgtgta     1680

tcgtctcctt ctccctaaag tgtacttaat ctttgctttc tttgcacaat gtctttggtt     1740

gcaagtcata agcctgaggc aaataaaatt ccagtaattt cgaagaatgt ggtgttggtg     1800

ctttcctaat aaagaaataa tttagcttga caaaaaaaaa aaaaaa                    1846


<210>  5
<211>  1590
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Arg  Cys Asn Val Glu Lys  Val Pro Ser Asn Ser  Gln Leu Glu 
    1400                 1405                 1410             


Ile Glu  Gly Asn Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1415                 1420                 1425             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1430                 1435                 1440             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1445                 1450                 1455             


His Lys  Tyr Arg Ser Leu Gly  Asp Leu Glu Lys Asp  Val Met Leu 
    1460                 1465                 1470             


Leu Cys  His Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Gln Ile 
    1475                 1480                 1485             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Lys  Ser Ala Arg 
    1490                 1495                 1500             


Gln Lys  Ile Ala Lys Glu Glu  Glu Ser Glu Asp Glu  Ser Asn Glu 
    1505                 1510                 1515             


Glu Glu  Glu Glu Glu Asp Glu  Glu Glu Ser Glu Ser  Glu Ala Lys 
    1520                 1525                 1530             


Ser Val  Lys Val Lys Ile Lys  Leu Asn Lys Lys Asp  Asp Lys Gly 
    1535                 1540                 1545             


Arg Asp  Lys Gly Lys Gly Lys  Lys Arg Pro Asn Arg  Gly Lys Ala 
    1550                 1555                 1560             


Lys Pro  Val Val Ser Asp Phe  Asp Ser Asp Glu Glu  Gln Asp Glu 
    1565                 1570                 1575             


Arg Glu  Gln Ser Glu Gly Ser  Gly Thr Asp Asp Glu  
    1580                 1585                 1590 


<210>  6
<211>  1572
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Ser  Ser Gly Arg Gln Leu  Ser Glu Val Phe Ile  Gln Leu Pro 
    1400                 1405                 1410             


Ser Arg  Lys Glu Leu Pro Glu  Tyr Tyr Glu Leu Ile  Arg Lys Pro 
    1415                 1420                 1425             


Val Asp  Phe Lys Lys Ile Lys  Glu Arg Ile Arg Asn  His Lys Tyr 
    1430                 1435                 1440             


Arg Ser  Leu Gly Asp Leu Glu  Lys Asp Val Met Leu  Leu Cys His 
    1445                 1450                 1455             


Asn Ala  Gln Thr Phe Asn Leu  Glu Gly Ser Gln Ile  Tyr Glu Asp 
    1460                 1465                 1470             


Ser Ile  Val Leu Gln Ser Val  Phe Lys Ser Ala Arg  Gln Lys Ile 
    1475                 1480                 1485             


Ala Lys  Glu Glu Glu Ser Glu  Asp Glu Ser Asn Glu  Glu Glu Glu 
    1490                 1495                 1500             


Glu Glu  Asp Glu Glu Glu Ser  Glu Ser Glu Ala Lys  Ser Val Lys 
    1505                 1510                 1515             


Val Lys  Ile Lys Leu Asn Lys  Lys Asp Asp Lys Gly  Arg Asp Lys 
    1520                 1525                 1530             


Gly Lys  Gly Lys Lys Arg Pro  Asn Arg Gly Lys Ala  Lys Pro Val 
    1535                 1540                 1545             


Val Ser  Asp Phe Asp Ser Asp  Glu Glu Gln Asp Glu  Arg Glu Gln 
    1550                 1555                 1560             


Ser Glu  Gly Ser Gly Thr Asp  Asp Glu 
    1565                 1570         


<210>  7
<211>  1514
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Asp Leu Asn Glu Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu 
865                 870                 875                 880 


His Lys Val Leu Arg Pro Phe Leu Leu Arg Arg Leu Lys Lys Glu Val 
                885                 890                 895     


Glu Ser Gln Leu Pro Glu Lys Val Glu Tyr Val Ile Lys Cys Asp Met 
            900                 905                 910         


Ser Ala Leu Gln Lys Ile Leu Tyr Arg His Met Gln Ala Lys Gly Ile 
        915                 920                 925             


Leu Leu Thr Asp Gly Ser Glu Lys Asp Lys Lys Gly Lys Gly Gly Ala 
    930                 935                 940                 


Lys Thr Leu Met Asn Thr Ile Met Gln Leu Arg Lys Ile Cys Asn His 
945                 950                 955                 960 


Pro Tyr Met Phe Gln His Ile Glu Glu Ser Phe Ala Glu His Leu Gly 
                965                 970                 975     


Tyr Ser Asn Gly Val Ile Asn Gly Ala Glu Leu Tyr Arg Ala Ser Gly 
            980                 985                 990         


Lys Phe Glu Leu Leu Asp Arg Ile  Leu Pro Lys Leu Arg  Ala Thr Asn 
        995                 1000                 1005             


His Arg  Val Leu Leu Phe Cys  Gln Met Thr Ser Leu  Met Thr Ile 
    1010                 1015                 1020             


Met Glu  Asp Tyr Phe Ala Phe  Arg Asn Phe Leu Tyr  Leu Arg Leu 
    1025                 1030                 1035             


Asp Gly  Thr Thr Lys Ser Glu  Asp Arg Ala Ala Leu  Leu Lys Lys 
    1040                 1045                 1050             


Phe Asn  Glu Pro Gly Ser Gln  Tyr Phe Ile Phe Leu  Leu Ser Thr 
    1055                 1060                 1065             


Arg Ala  Gly Gly Leu Gly Leu  Asn Leu Gln Ala Ala  Asp Thr Val 
    1070                 1075                 1080             


Val Ile  Phe Asp Ser Asp Trp  Asn Pro His Gln Asp  Leu Gln Ala 
    1085                 1090                 1095             


Gln Asp  Arg Ala His Arg Ile  Gly Gln Gln Asn Glu  Val Arg Val 
    1100                 1105                 1110             


Leu Arg  Leu Cys Thr Val Asn  Ser Val Glu Glu Lys  Ile Leu Ala 
    1115                 1120                 1125             


Ala Ala  Lys Tyr Lys Leu Asn  Val Asp Gln Lys Val  Ile Gln Ala 
    1130                 1135                 1140             


Gly Met  Phe Asp Gln Lys Ser  Ser Ser His Glu Arg  Arg Ala Phe 
    1145                 1150                 1155             


Leu Gln  Ala Ile Leu Glu His  Glu Glu Glu Asn Glu  Glu Glu Asp 
    1160                 1165                 1170             


Glu Val  Pro Asp Asp Glu Thr  Leu Asn Gln Met Ile  Ala Arg Arg 
    1175                 1180                 1185             


Glu Glu  Glu Phe Asp Leu Phe  Met Arg Met Asp Met  Asp Arg Arg 
    1190                 1195                 1200             


Arg Glu  Asp Ala Arg Asn Pro  Lys Arg Lys Pro Arg  Leu Met Glu 
    1205                 1210                 1215             


Glu Asp  Glu Leu Pro Ser Trp  Ile Ile Lys Asp Asp  Ala Glu Val 
    1220                 1225                 1230             


Glu Arg  Leu Thr Cys Glu Glu  Glu Glu Glu Lys Ile  Phe Gly Arg 
    1235                 1240                 1245             


Gly Ser  Arg Gln Arg Arg Asp  Val Asp Tyr Ser Asp  Ala Leu Thr 
    1250                 1255                 1260             


Glu Lys  Gln Trp Leu Arg Ala  Ile Glu Asp Gly Asn  Leu Glu Glu 
    1265                 1270                 1275             


Met Glu  Glu Glu Val Arg Leu  Lys Lys Arg Lys Arg  Arg Arg Asn 
    1280                 1285                 1290             


Val Asp  Lys Asp Pro Ala Lys  Glu Asp Val Glu Lys  Ala Lys Lys 
    1295                 1300                 1305             


Arg Arg  Gly Arg Pro Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro 
    1310                 1315                 1320             


Lys Leu  Thr Lys Gln Met Asn  Ala Ile Ile Asp Thr  Val Ile Asn 
    1325                 1330                 1335             


Tyr Lys  Asp Ser Ser Gly Arg  Gln Leu Ser Glu Val  Phe Ile Gln 
    1340                 1345                 1350             


Leu Pro  Ser Arg Lys Glu Leu  Pro Glu Tyr Tyr Glu  Leu Ile Arg 
    1355                 1360                 1365             


Lys Pro  Val Asp Phe Lys Lys  Ile Lys Glu Arg Ile  Arg Asn His 
    1370                 1375                 1380             


Lys Tyr  Arg Ser Leu Gly Asp  Leu Glu Lys Asp Val  Met Leu Leu 
    1385                 1390                 1395             


Cys His  Asn Ala Gln Thr Phe  Asn Leu Glu Gly Ser  Gln Ile Tyr 
    1400                 1405                 1410             


Glu Asp  Ser Ile Val Leu Gln  Ser Val Phe Lys Ser  Ala Arg Gln 
    1415                 1420                 1425             


Lys Ile  Ala Lys Glu Glu Glu  Ser Glu Asp Glu Ser  Asn Glu Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Asp Glu Glu  Glu Ser Glu Ser Glu  Ala Lys Ser 
    1445                 1450                 1455             


Val Lys  Val Lys Ile Lys Leu  Asn Lys Lys Asp Asp  Lys Gly Arg 
    1460                 1465                 1470             


Asp Lys  Gly Lys Gly Lys Lys  Arg Pro Asn Arg Gly  Lys Ala Lys 
    1475                 1480                 1485             


Pro Val  Val Ser Asp Phe Asp  Ser Asp Glu Glu Gln  Asp Glu Arg 
    1490                 1495                 1500             


Glu Gln  Ser Glu Gly Ser Gly  Thr Asp Asp Glu 
    1505                 1510                 


<210>  8
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Leu Ala Ile Glu Asp Gly Asn Leu Glu Glu Met Glu Glu Glu 
1               5                   10                  15      


Val Arg Leu Lys Lys Arg Lys Arg Arg Arg Asn Val Asp Lys Asp Pro 
            20                  25                  30          


Ala Lys Glu Asp Val Glu Lys Ala Lys Lys Arg Arg Gly Arg Pro Pro 
        35                  40                  45              


Ala Glu Lys Leu Ser Pro Asn Pro Pro Lys Leu Thr Lys Gln Met Asn 
    50                  55                  60                  


Ala Ile Ile Asp Thr Val Ile Asn Tyr Lys Asp Ser Ser Gly Arg Gln 
65                  70                  75                  80  


Leu Ser Glu Val Phe Ile Gln Leu Pro Ser Arg Lys Glu Leu Pro Glu 
                85                  90                  95      


Tyr Tyr Glu Leu Ile Arg Lys Pro Val Asp Phe Lys Lys Ile Lys Glu 
            100                 105                 110         


Arg Ile Arg Asn His Lys Tyr Arg Ser Leu Gly Asp Leu Glu Lys Asp 
        115                 120                 125             


Val Met Leu Leu Cys His Asn Ala Gln Thr Phe Asn Leu Glu Gly Ser 
    130                 135                 140                 


Gln Ile Tyr Glu Asp Ser Ile Val Leu Gln Ser Val Phe Lys Ser Ala 
145                 150                 155                 160 


Arg Gln Lys Ile Ala Lys Glu Glu Glu Ser Glu Asp Glu Ser Asn Glu 
                165                 170                 175     


Glu Glu Glu Glu Glu Asp Glu Glu Glu Ser Glu Ser Glu Ala Lys Ser 
            180                 185                 190         


Val Lys Val Lys Ile Lys Leu Asn Lys Lys Asp Asp Lys Gly Arg Asp 
        195                 200                 205             


Lys Gly Lys Gly Lys Lys Arg Pro Asn Arg Gly Lys Ala Lys Pro Val 
    210                 215                 220                 


Val Ser Asp Phe Asp Ser Asp Glu Glu Gln Asp Glu Arg Glu Gln Ser 
225                 230                 235                 240 


Glu Gly Ser Gly Thr Asp Asp Glu 
                245             


<210>  9
<211>  5589
<212>  DNA
<213>  Homo sapiens

<400>  9
ggcgggggag gcgccgggaa gtcgacggcg ccggcggctc ctgcaggagg ccactgtctg       60

cagctcccgt gaagatgtcc actccagacc cacccctggg cggaactcct cggccaggtc      120

cttccccggg ccctggccct tcccctggag ccatgctggg ccctagcccg ggtccctcgc      180

cgggctccgc ccacagcatg atggggccca gcccagggcc gccctcagca ggacacccca      240

tccccaccca ggggcctgga gggtaccctc aggacaacat gcaccagatg cacaagccca      300

tggagtccat gcatgagaag ggcatgtcgg acgacccgcg ctacaaccag atgaaaggaa      360

tggggatgcg gtcagggggc catgctggga tggggccccc gcccagcccc atggaccagc      420

actcccaagg ttacccctcg cccctgggtg gctctgagca tgcctctagt ccagttccag      480

ccagtggccc gtcttcgggg ccccagatgt cttccgggcc aggaggtgcc ccgctggatg      540

gtgctgaccc ccaggccttg gggcagcaga accggggccc aaccccattt aaccagaacc      600

agctgcacca gctcagagct cagatcatgg cctacaagat gctggccagg gggcagcccc      660

tccccgacca cctgcagatg gcggtgcagg gcaagcggcc gatgcccggg atgcagcagc      720

agatgccaac gctacctcca ccctcggtgt ccgcaacagg acccggccct ggccctggcc      780

ctggccccgg cccgggtccc ggcccggcac ctccaaatta cagcaggcct catggtatgg      840

gagggcccaa catgcctccc ccaggaccct cgggcgtgcc ccccgggatg ccaggccagc      900

ctcctggagg gcctcccaag ccctggcctg aaggacccat ggcgaatgct gctgccccca      960

cgagcacccc tcagaagctg attcccccgc agccaacggg ccgcccttcc cccgcgcccc     1020

ctgccgtccc acccgccgcc tcgcccgtga tgccaccgca gacccagtcc cccgggcagc     1080

cggcccagcc cgcgcccatg gtgccactgc accagaagca gagccgcatc acccccatcc     1140

agaagccgcg gggcctcgac cctgtggaga tcctgcagga gcgcgagtac aggctgcagg     1200

ctcgcatcgc acaccgaatt caggaacttg aaaaccttcc cgggtccctg gccggggatt     1260

tgcgaaccaa agcgaccatt gagctcaagg ccctcaggct gctgaacttc cagaggcagc     1320

tgcgccagga ggtggtggtg tgcatgcgga gggacacagc gctggagaca gccctcaatg     1380

ctaaggccta caagcgcagc aagcgccagt ccctgcgcga ggcccgcatc actgagaagc     1440

tggagaagca gcagaagatc gagcaggagc gcaagcgccg gcagaagcac caggaatacc     1500

tcaatagcat tctccagcat gccaaggatt tcaaggaata tcacagatcc gtcacaggca     1560

aaatccagaa gctgaccaag gcagtggcca cgtaccatgc caacacggag cgggagcaga     1620

agaaagagaa cgagcggatc gagaaggagc gcatgcggag gctcatggct gaagatgagg     1680

aggggtaccg caagctcatc gaccagaaga aggacaagcg cctggcctac ctcttgcagc     1740

agacagacga gtacgtggct aacctcacgg agctggtgcg gcagcacaag gctgcccagg     1800

tcgccaagga gaaaaagaag aaaaagaaaa agaagaaggc agaaaatgca gaaggacaga     1860

cgcctgccat tgggccggat ggcgagcctc tggacgagac cagccagatg agcgacctcc     1920

cggtgaaggt gatccacgtg gagagtggga agatcctcac aggcacagat gcccccaaag     1980

ccgggcagct ggaggcctgg ctcgagatga acccggggta tgaagtagct ccgaggtctg     2040

atagtgaaga aagtggctca gaagaagagg aagaggagga ggaggaagag cagccgcagg     2100

cagcacagcc tcccaccctg cccgtggagg agaagaagaa gattccagat ccagacagcg     2160

atgacgtctc tgaggtggac gcgcggcaca tcattgagaa tgccaagcaa gatgtcgatg     2220

atgaatatgg cgtgtcccag gcccttgcac gtggcctgca gtcctactat gccgtggccc     2280

atgctgtcac tgagagagtg gacaagcagt cagcgcttat ggtcaatggt gtcctcaaac     2340

agtaccagat caaaggtttg gagtggctgg tgtccctgta caacaacaac ctgaacggca     2400

tcctggccga cgagatgggc ctggggaaga ccatccagac catcgcgctc atcacgtacc     2460

tcatggagca caaacgcatc aatgggccct tcctcatcat cgtgcctctc tcaacgctgt     2520

ccaactgggc gtacgagttt gacaagtggg ccccctccgt ggtgaaggtg tcttacaagg     2580

gatccccagc agcaagacgg gcctttgtcc cccagctccg gagtgggaag ttcaacgtct     2640

tgctgacgac gtacgagtac atcatcaaag acaagcacat cctcgccaag atccgttgga     2700

agtacatgat tgtggacgaa ggtcaccgca tgaagaacca ccactgcaag ctgacgcagg     2760

tgctcaacac gcactatgtg gcaccccgcc gcctgctgct gacgggcaca ccgctgcaga     2820

acaagcttcc cgagctctgg gcgctgctca acttcctgct gcccaccatc ttcaagagct     2880

gcagcacctt cgagcagtgg tttaacgcac cctttgccat gaccggggaa aaggtggacc     2940

tgaatgagga ggaaaccatt ctcatcatcc ggcgtctcca caaagtgctg cggcccttct     3000

tgctccgacg actcaagaag gaagtcgagg cccagttgcc cgaaaaggtg gagtacgtca     3060

tcaagtgcga catgtctgcg ctgcagcgag tgctctaccg ccacatgcag gccaagggcg     3120

tgctgctgac tgatggctcc gagaaggaca agaagggcaa aggcggcacc aagaccctga     3180

tgaacaccat catgcagctg cggaagatct gcaaccaccc ctacatgttc cagcacatcg     3240

aggagtcctt ttccgagcac ttggggttca ctggcggcat tgtccaaggg ctggacctgt     3300

accgagcctc gggtaaattt gagcttcttg atagaattct tcccaaactc cgagcaacca     3360

accacaaagt gctgctgttc tgccaaatga cctccctcat gaccatcatg gaagattact     3420

ttgcgtatcg cggctttaaa tacctcaggc ttgatggaac cacgaaggcg gaggaccggg     3480

gcatgctgct gaaaaccttc aacgagcccg gctctgagta cttcatcttc ctgctcagca     3540

cccgggctgg ggggctcggc ctgaacctcc agtcggcaga cactgtgatc atttttgaca     3600

gcgactggaa tcctcaccag gacctgcaag cgcaggaccg agcccaccgc atcgggcagc     3660

agaacgaggt gcgtgtgctc cgcctctgca ccgtcaacag cgtggaggag aagatcctag     3720

ctgcagccaa gtacaagctc aacgtggacc agaaggtgat ccaggccggc atgttcgacc     3780

agaagtcctc cagccatgag cggcgcgcct tcctgcaggc catcctggag cacgaggagc     3840

aggatgagag cagacactgc agcacgggca gcggcagtgc cagcttcgcc cacactgccc     3900

ctccgccagc gggcgtcaac cccgacttgg aggagccacc tctaaaggag gaagacgagg     3960

tgcccgacga cgagaccgtc aaccagatga tcgcccggca cgaggaggag tttgatctgt     4020

tcatgcgcat ggacctggac cgcaggcgcg aggaggcccg caaccccaag cggaagccgc     4080

gcctcatgga ggaggacgag ctcccctcgt ggatcatcaa ggacgacgcg gaggtggagc     4140

ggctgacctg tgaggaggag gaggagaaga tgttcggccg tggctcccgc caccgcaagg     4200

aggtggacta cagcgactca ctgacggaga agcagtggct caagaaaatt acaggaaaag     4260

atatccatga cacagccagc agtgtggcac gtgggctaca attccagcgt ggccttcagt     4320

tctgcacacg tgcgtcaaag gccatcgagg agggcacgct ggaggagatc gaagaggagg     4380

tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc tcctccaccc     4440

cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag aagaagcgcg     4500

ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag aagatgaaga     4560

agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag ctcagcgagg     4620

tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc atccgcaagc     4680

ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc agcctcaacg     4740

acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac ctggagggct     4800

ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg cggcagaaaa     4860

tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag ggcgaggagg     4920

aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc cggaaggaga     4980

aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc cgagccaagc     5040

cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca ggaagtggca     5100

gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt tccagagctg     5160

agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga cttggagtaa     5220

aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta ggactgtttg     5280

tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc ttaaagagag     5340

agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc gttgctggca     5400

gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg tgcgtcaccg     5460

tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc cggcgagggt     5520

atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa acgcacagcc     5580

aaaaaaaaa                                                             5589


<210>  10
<211>  5779
<212>  DNA
<213>  Homo sapiens

<400>  10
ggagaggccg ccgcggtgct gagggggagg ggagccggcg agcgcgcgcg cagcgggggc       60

gcgggtggcg cgcgtgtgtg tgaagggggg gcggtggccg aggcgggcgg gcgcgcgcgc      120

gaggcttccc ctcgtttggc ggcggcggcg gcttctttgt ttcgtgaaga gaagcgagac      180

gcccattctg cccccggccc cgcgcggagg ggcgggggag gcgccgggaa gtcgacggcg      240

ccggcggctc ctgcgtctcg cccttttgcc caggctagag tgcagtggtg cggtcatggt      300

tcactgcagc ctcaacctcc tggactcagc aggaggccac tgtctgcagc tcccgtgaag      360

atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct      420

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      480

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      540

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      600

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      660

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      720

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      780

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      840

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      900

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      960

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta     1020

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg     1080

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg     1140

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct     1200

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag     1260

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc     1320

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1380

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1440

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1500

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1560

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1620

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1680

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1740

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1800

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1860

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1920

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1980

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     2040

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     2100

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     2160

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     2220

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     2280

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     2340

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2400

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2460

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2520

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2580

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2640

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2700

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2760

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2820

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2880

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2940

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     3000

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     3060

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     3120

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     3180

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     3240

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     3300

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3360

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3420

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3480

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3540

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3600

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3660

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3720

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3780

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3840

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3900

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3960

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     4020

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     4080

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgagagcaga     4140

cactgcagca cgggcagcgg cagtgccagc ttcgcccaca ctgcccctcc gccagcgggc     4200

gtcaaccccg acttggagga gccacctcta aaggaggaag acgaggtgcc cgacgacgag     4260

accgtcaacc agatgatcgc ccggcacgag gaggagtttg atctgttcat gcgcatggac     4320

ctggaccgca ggcgcgagga ggcccgcaac cccaagcgga agccgcgcct catggaggag     4380

gacgagctcc cctcgtggat catcaaggac gacgcggagg tggagcggct gacctgtgag     4440

gaggaggagg agaagatgtt cggccgtggc tcccgccacc gcaaggaggt ggactacagc     4500

gactcactga cggagaagca gtggctcaag gccatcgagg agggcacgct ggaggagatc     4560

gaagaggagg tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc     4620

tcctccaccc cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag     4680

aagaagcgcg ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag     4740

aagatgaaga agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag     4800

ctcagcgagg tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc     4860

atccgcaagc ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc     4920

agcctcaacg acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac     4980

ctggagggct ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg     5040

cggcagaaaa tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag     5100

ggcgaggagg aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc     5160

cggaaggaga aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc     5220

cgagccaagc cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca     5280

ggaagtggca gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt     5340

tccagagctg agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga     5400

cttggagtaa aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta     5460

ggactgtttg tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc     5520

ttaaagagag agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc     5580

gttgctggca gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg     5640

tgcgtcaccg tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc     5700

cggcgagggt atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa     5760

acgcacagcc aaaaaaaaa                                                  5779


<210>  11
<211>  5329
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa gaccctgaag     4080

gccatcgagg agggcacgct ggaggagatc gaagaggagg tccggcagaa gaaatcatca     4140

cggaagcgca agcgagacag cgacgccggc tcctccaccc cgaccaccag cacccgcagc     4200

cgcgacaagg acgacgagag caagaagcag aagaagcgcg ggcggccgcc tgccgagaaa     4260

ctctccccta acccacccaa cctcaccaag aagatgaaga agattgtgga tgccgtgatc     4320

aagtacaagg acagcagcag tggacgtcag ctcagcgagg tcttcatcca gctgccctcg     4380

cgaaaggagc tgcccgagta ctacgagctc atccgcaagc ccgtggactt caagaagata     4440

aaggagcgca ttcgcaacca caagtaccgc agcctcaacg acctagagaa ggacgtcatg     4500

ctcctgtgcc agaacgcaca gaccttcaac ctggagggct ccctgatcta tgaagactcc     4560

atcgtcttgc agtcggtctt caccagcgtg cggcagaaaa tcgagaagga ggatgacagt     4620

gaaggcgagg agagtgagga ggaggaagag ggcgaggagg aaggctccga atccgaatct     4680

cggtccgtca aagtgaagat caagcttggc cggaaggaga aggcacagga ccggctgaag     4740

ggcggccggc ggcggccgag ccgagggtcc cgagccaagc cggtcgtgag tgacgatgac     4800

agtgaggagg aacaagagga ggaccgctca ggaagtggca gcgaagaaga ctgagccccg     4860

acattccagt ctcgaccccg agcccctcgt tccagagctg agatggcata ggccttagca     4920

gtaacgggta gcagcagatg tagtttcaga cttggagtaa aactgtataa acaaaagaat     4980

cttccatatt tatacagcag agaagctgta ggactgtttg tgactggccc tgtcctggca     5040

tcagtagcat ctgtaacagc attaactgtc ttaaagagag agagagagaa ttccgaattg     5100

gggaacacac gatacctgtt tttcttttcc gttgctggca gtactgttgc gccgcagttt     5160

ggagtcactg tagttaagtg tggatgcatg tgcgtcaccg tccactcctc ctactgtatt     5220

ttattggaca ggtcagactc gccgggggcc cggcgagggt atgtcagtgt cactggatgt     5280

caaacagtaa taaattaaac caacaacaaa acgcacagcc aaaaaaaaa                 5329


<210>  12
<211>  5326
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa gaccctgaag     4080

gccatcgagg agggcacgct ggaggagatc gaagaggagg tccggcagaa gaaatcatca     4140

cggaagcgca agcgagacag cgacgccggc tcctccaccc cgaccaccag cacccgcagc     4200

cgcgacaagg acgacgagag caagaagcag aagaagcgcg ggcggccgcc tgccgagaaa     4260

ctctccccta acccacccaa cctcaccaag aagatgaaga agattgtgga tgccgtgatc     4320

aagtacaagg acagcagtgg acgtcagctc agcgaggtct tcatccagct gccctcgcga     4380

aaggagctgc ccgagtacta cgagctcatc cgcaagcccg tggacttcaa gaagataaag     4440

gagcgcattc gcaaccacaa gtaccgcagc ctcaacgacc tagagaagga cgtcatgctc     4500

ctgtgccaga acgcacagac cttcaacctg gagggctccc tgatctatga agactccatc     4560

gtcttgcagt cggtcttcac cagcgtgcgg cagaaaatcg agaaggagga tgacagtgaa     4620

ggcgaggaga gtgaggagga ggaagagggc gaggaggaag gctccgaatc cgaatctcgg     4680

tccgtcaaag tgaagatcaa gcttggccgg aaggagaagg cacaggaccg gctgaagggc     4740

ggccggcggc ggccgagccg agggtcccga gccaagccgg tcgtgagtga cgatgacagt     4800

gaggaggaac aagaggagga ccgctcagga agtggcagcg aagaagactg agccccgaca     4860

ttccagtctc gaccccgagc ccctcgttcc agagctgaga tggcataggc cttagcagta     4920

acgggtagca gcagatgtag tttcagactt ggagtaaaac tgtataaaca aaagaatctt     4980

ccatatttat acagcagaga agctgtagga ctgtttgtga ctggccctgt cctggcatca     5040

gtagcatctg taacagcatt aactgtctta aagagagaga gagagaattc cgaattgggg     5100

aacacacgat acctgttttt cttttccgtt gctggcagta ctgttgcgcc gcagtttgga     5160

gtcactgtag ttaagtgtgg atgcatgtgc gtcaccgtcc actcctccta ctgtatttta     5220

ttggacaggt cagactcgcc gggggcccgg cgagggtatg tcagtgtcac tggatgtcaa     5280

acagtaataa attaaaccaa caacaaaacg cacagccaaa aaaaaa                    5326


<210>  13
<211>  5320
<212>  DNA
<213>  Homo sapiens

<400>  13
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa ggccatcgag     4080

gagggcacgc tggaggagat cgaagaggag gtccggcaga agaaatcatc acggaagcgc     4140

aagcgagaca gcgacgccgg ctcctccacc ccgaccacca gcacccgcag ccgcgacaag     4200

gacgacgaga gcaagaagca gaagaagcgc gggcggccgc ctgccgagaa actctcccct     4260

aacccaccca acctcaccaa gaagatgaag aagattgtgg atgccgtgat caagtacaag     4320

gacagcagca gtggacgtca gctcagcgag gtcttcatcc agctgccctc gcgaaaggag     4380

ctgcccgagt actacgagct catccgcaag cccgtggact tcaagaagat aaaggagcgc     4440

attcgcaacc acaagtaccg cagcctcaac gacctagaga aggacgtcat gctcctgtgc     4500

cagaacgcac agaccttcaa cctggagggc tccctgatct atgaagactc catcgtcttg     4560

cagtcggtct tcaccagcgt gcggcagaaa atcgagaagg aggatgacag tgaaggcgag     4620

gagagtgagg aggaggaaga gggcgaggag gaaggctccg aatccgaatc tcggtccgtc     4680

aaagtgaaga tcaagcttgg ccggaaggag aaggcacagg accggctgaa gggcggccgg     4740

cggcggccga gccgagggtc ccgagccaag ccggtcgtga gtgacgatga cagtgaggag     4800

gaacaagagg aggaccgctc aggaagtggc agcgaagaag actgagcccc gacattccag     4860

tctcgacccc gagcccctcg ttccagagct gagatggcat aggccttagc agtaacgggt     4920

agcagcagat gtagtttcag acttggagta aaactgtata aacaaaagaa tcttccatat     4980

ttatacagca gagaagctgt aggactgttt gtgactggcc ctgtcctggc atcagtagca     5040

tctgtaacag cattaactgt cttaaagaga gagagagaga attccgaatt ggggaacaca     5100

cgatacctgt ttttcttttc cgttgctggc agtactgttg cgccgcagtt tggagtcact     5160

gtagttaagt gtggatgcat gtgcgtcacc gtccactcct cctactgtat tttattggac     5220

aggtcagact cgccgggggc ccggcgaggg tatgtcagtg tcactggatg tcaaacagta     5280

ataaattaaa ccaacaacaa aacgcacagc caaaaaaaaa                           5320


<210>  14
<211>  5317
<212>  DNA
<213>  Homo sapiens

<400>  14
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgaggaggaa     3780

gacgaggtgc ccgacgacga gaccgtcaac cagatgatcg cccggcacga ggaggagttt     3840

gatctgttca tgcgcatgga cctggaccgc aggcgcgagg aggcccgcaa ccccaagcgg     3900

aagccgcgcc tcatggagga ggacgagctc ccctcgtgga tcatcaagga cgacgcggag     3960

gtggagcggc tgacctgtga ggaggaggag gagaagatgt tcggccgtgg ctcccgccac     4020

cgcaaggagg tggactacag cgactcactg acggagaagc agtggctcaa ggccatcgag     4080

gagggcacgc tggaggagat cgaagaggag gtccggcaga agaaatcatc acggaagcgc     4140

aagcgagaca gcgacgccgg ctcctccacc ccgaccacca gcacccgcag ccgcgacaag     4200

gacgacgaga gcaagaagca gaagaagcgc gggcggccgc ctgccgagaa actctcccct     4260

aacccaccca acctcaccaa gaagatgaag aagattgtgg atgccgtgat caagtacaag     4320

gacagcagtg gacgtcagct cagcgaggtc ttcatccagc tgccctcgcg aaaggagctg     4380

cccgagtact acgagctcat ccgcaagccc gtggacttca agaagataaa ggagcgcatt     4440

cgcaaccaca agtaccgcag cctcaacgac ctagagaagg acgtcatgct cctgtgccag     4500

aacgcacaga ccttcaacct ggagggctcc ctgatctatg aagactccat cgtcttgcag     4560

tcggtcttca ccagcgtgcg gcagaaaatc gagaaggagg atgacagtga aggcgaggag     4620

agtgaggagg aggaagaggg cgaggaggaa ggctccgaat ccgaatctcg gtccgtcaaa     4680

gtgaagatca agcttggccg gaaggagaag gcacaggacc ggctgaaggg cggccggcgg     4740

cggccgagcc gagggtcccg agccaagccg gtcgtgagtg acgatgacag tgaggaggaa     4800

caagaggagg accgctcagg aagtggcagc gaagaagact gagccccgac attccagtct     4860

cgaccccgag cccctcgttc cagagctgag atggcatagg ccttagcagt aacgggtagc     4920

agcagatgta gtttcagact tggagtaaaa ctgtataaac aaaagaatct tccatattta     4980

tacagcagag aagctgtagg actgtttgtg actggccctg tcctggcatc agtagcatct     5040

gtaacagcat taactgtctt aaagagagag agagagaatt ccgaattggg gaacacacga     5100

tacctgtttt tcttttccgt tgctggcagt actgttgcgc cgcagtttgg agtcactgta     5160

gttaagtgtg gatgcatgtg cgtcaccgtc cactcctcct actgtatttt attggacagg     5220

tcagactcgc cgggggcccg gcgagggtat gtcagtgtca ctggatgtca aacagtaata     5280

aattaaacca acaacaaaac gcacagccaa aaaaaaa                              5317


<210>  15
<211>  1679
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Lys Ile Thr Gly Lys  Asp Ile His 
    1385                 1390                 1395             


Asp Thr  Ala Ser Ser Val Ala  Arg Gly Leu Gln Phe  Gln Arg Gly 
    1400                 1405                 1410             


Leu Gln  Phe Cys Thr Arg Ala  Ser Lys Ala Ile Glu  Glu Gly Thr 
    1415                 1420                 1425             


Leu Glu  Glu Ile Glu Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg 
    1430                 1435                 1440             


Lys Arg  Lys Arg Asp Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr 
    1445                 1450                 1455             


Ser Thr  Arg Ser Arg Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys 
    1460                 1465                 1470             


Lys Arg  Gly Arg Pro Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro 
    1475                 1480                 1485             


Asn Leu  Thr Lys Lys Met Lys  Lys Ile Val Asp Ala  Val Ile Lys 
    1490                 1495                 1500             


Tyr Lys  Asp Ser Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1505                 1510                 1515             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1520                 1525                 1530             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1535                 1540                 1545             


His Lys  Tyr Arg Ser Leu Asn  Asp Leu Glu Lys Asp  Val Met Leu 
    1550                 1555                 1560             


Leu Cys  Gln Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Leu Ile 
    1565                 1570                 1575             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Thr  Ser Val Arg 
    1580                 1585                 1590             


Gln Lys  Ile Glu Lys Glu Asp  Asp Ser Glu Gly Glu  Glu Ser Glu 
    1595                 1600                 1605             


Glu Glu  Glu Glu Gly Glu Glu  Glu Gly Ser Glu Ser  Glu Ser Arg 
    1610                 1615                 1620             


Ser Val  Lys Val Lys Ile Lys  Leu Gly Arg Lys Glu  Lys Ala Gln 
    1625                 1630                 1635             


Asp Arg  Leu Lys Gly Gly Arg  Arg Arg Pro Ser Arg  Gly Ser Arg 
    1640                 1645                 1650             


Ala Lys  Pro Val Val Ser Asp  Asp Asp Ser Glu Glu  Glu Gln Glu 
    1655                 1660                 1665             


Glu Asp  Arg Ser Gly Ser Gly  Ser Glu Glu Asp 
    1670                 1675                 


<210>  16
<211>  1647
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210>  17
<211>  1617
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Thr Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1355                 1360                 1365             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1370                 1375                 1380             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1385                 1390                 1395             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1400                 1405                 1410             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1415                 1420                 1425             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1430                 1435                 1440             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1445                 1450                 1455             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1460                 1465                 1470             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1475                 1480                 1485             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1490                 1495                 1500             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1505                 1510                 1515             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1520                 1525                 1530             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1535                 1540                 1545             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1550                 1555                 1560             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1565                 1570                 1575             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1580                 1585                 1590             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1595                 1600                 1605             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1610                 1615         


<210>  18
<211>  1616
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Thr Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1355                 1360                 1365             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1370                 1375                 1380             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1385                 1390                 1395             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1400                 1405                 1410             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1415                 1420                 1425             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1430                 1435                 1440             


Asp Ser  Ser Gly Arg Gln Leu  Ser Glu Val Phe Ile  Gln Leu Pro 
    1445                 1450                 1455             


Ser Arg  Lys Glu Leu Pro Glu  Tyr Tyr Glu Leu Ile  Arg Lys Pro 
    1460                 1465                 1470             


Val Asp  Phe Lys Lys Ile Lys  Glu Arg Ile Arg Asn  His Lys Tyr 
    1475                 1480                 1485             


Arg Ser  Leu Asn Asp Leu Glu  Lys Asp Val Met Leu  Leu Cys Gln 
    1490                 1495                 1500             


Asn Ala  Gln Thr Phe Asn Leu  Glu Gly Ser Leu Ile  Tyr Glu Asp 
    1505                 1510                 1515             


Ser Ile  Val Leu Gln Ser Val  Phe Thr Ser Val Arg  Gln Lys Ile 
    1520                 1525                 1530             


Glu Lys  Glu Asp Asp Ser Glu  Gly Glu Glu Ser Glu  Glu Glu Glu 
    1535                 1540                 1545             


Glu Gly  Glu Glu Glu Gly Ser  Glu Ser Glu Ser Arg  Ser Val Lys 
    1550                 1555                 1560             


Val Lys  Ile Lys Leu Gly Arg  Lys Glu Lys Ala Gln  Asp Arg Leu 
    1565                 1570                 1575             


Lys Gly  Gly Arg Arg Arg Pro  Ser Arg Gly Ser Arg  Ala Lys Pro 
    1580                 1585                 1590             


Val Val  Ser Asp Asp Asp Ser  Glu Glu Glu Gln Glu  Glu Asp Arg 
    1595                 1600                 1605             


Ser Gly  Ser Gly Ser Glu Glu  Asp 
    1610                 1615     


<210>  19
<211>  1614
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile Gln Leu  Pro Ser Arg 
    1445                 1450                 1455             


Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile Arg Lys  Pro Val Asp 
    1460                 1465                 1470             


Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn His Lys  Tyr Arg Ser 
    1475                 1480                 1485             


Leu Asn  Asp Leu Glu Lys Asp  Val Met Leu Leu Cys  Gln Asn Ala 
    1490                 1495                 1500             


Gln Thr  Phe Asn Leu Glu Gly  Ser Leu Ile Tyr Glu  Asp Ser Ile 
    1505                 1510                 1515             


Val Leu  Gln Ser Val Phe Thr  Ser Val Arg Gln Lys  Ile Glu Lys 
    1520                 1525                 1530             


Glu Asp  Asp Ser Glu Gly Glu  Glu Ser Glu Glu Glu  Glu Glu Gly 
    1535                 1540                 1545             


Glu Glu  Glu Gly Ser Glu Ser  Glu Ser Arg Ser Val  Lys Val Lys 
    1550                 1555                 1560             


Ile Lys  Leu Gly Arg Lys Glu  Lys Ala Gln Asp Arg  Leu Lys Gly 
    1565                 1570                 1575             


Gly Arg  Arg Arg Pro Ser Arg  Gly Ser Arg Ala Lys  Pro Val Val 
    1580                 1585                 1590             


Ser Asp  Asp Asp Ser Glu Glu  Glu Gln Glu Glu Asp  Arg Ser Gly 
    1595                 1600                 1605             


Ser Gly  Ser Glu Glu Asp 
    1610                 


<210>  20
<211>  1613
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Glu Glu  Asp Glu Val 
    1250                 1255                 1260             


Pro Asp  Asp Glu Thr Val Asn  Gln Met Ile Ala Arg  His Glu Glu 
    1265                 1270                 1275             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Leu Asp Arg  Arg Arg Glu 
    1280                 1285                 1290             


Glu Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1295                 1300                 1305             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1310                 1315                 1320             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Met Phe Gly  Arg Gly Ser 
    1325                 1330                 1335             


Arg His  Arg Lys Glu Val Asp  Tyr Ser Asp Ser Leu  Thr Glu Lys 
    1340                 1345                 1350             


Gln Trp  Leu Lys Ala Ile Glu  Glu Gly Thr Leu Glu  Glu Ile Glu 
    1355                 1360                 1365             


Glu Glu  Val Arg Gln Lys Lys  Ser Ser Arg Lys Arg  Lys Arg Asp 
    1370                 1375                 1380             


Ser Asp  Ala Gly Ser Ser Thr  Pro Thr Thr Ser Thr  Arg Ser Arg 
    1385                 1390                 1395             


Asp Lys  Asp Asp Glu Ser Lys  Lys Gln Lys Lys Arg  Gly Arg Pro 
    1400                 1405                 1410             


Pro Ala  Glu Lys Leu Ser Pro  Asn Pro Pro Asn Leu  Thr Lys Lys 
    1415                 1420                 1425             


Met Lys  Lys Ile Val Asp Ala  Val Ile Lys Tyr Lys  Asp Ser Ser 
    1430                 1435                 1440             


Gly Arg  Gln Leu Ser Glu Val  Phe Ile Gln Leu Pro  Ser Arg Lys 
    1445                 1450                 1455             


Glu Leu  Pro Glu Tyr Tyr Glu  Leu Ile Arg Lys Pro  Val Asp Phe 
    1460                 1465                 1470             


Lys Lys  Ile Lys Glu Arg Ile  Arg Asn His Lys Tyr  Arg Ser Leu 
    1475                 1480                 1485             


Asn Asp  Leu Glu Lys Asp Val  Met Leu Leu Cys Gln  Asn Ala Gln 
    1490                 1495                 1500             


Thr Phe  Asn Leu Glu Gly Ser  Leu Ile Tyr Glu Asp  Ser Ile Val 
    1505                 1510                 1515             


Leu Gln  Ser Val Phe Thr Ser  Val Arg Gln Lys Ile  Glu Lys Glu 
    1520                 1525                 1530             


Asp Asp  Ser Glu Gly Glu Glu  Ser Glu Glu Glu Glu  Glu Gly Glu 
    1535                 1540                 1545             


Glu Glu  Gly Ser Glu Ser Glu  Ser Arg Ser Val Lys  Val Lys Ile 
    1550                 1555                 1560             


Lys Leu  Gly Arg Lys Glu Lys  Ala Gln Asp Arg Leu  Lys Gly Gly 
    1565                 1570                 1575             


Arg Arg  Arg Pro Ser Arg Gly  Ser Arg Ala Lys Pro  Val Val Ser 
    1580                 1585                 1590             


Asp Asp  Asp Ser Glu Glu Glu  Gln Glu Glu Asp Arg  Ser Gly Ser 
    1595                 1600                 1605             


Gly Ser  Glu Glu Asp 
    1610             


