                         SEQUENCE LISTING

<110>  Sanofi
       BioNTech RNA Pharmaceuticals GMBH
 
<120>  Therapeutic RNA

<130>  01183-0001-00PCT

<150>  US 62/464,981
<151>  2017-02-28

<150>  US 62/597,527
<151>  2017-12-12

<150>  EP 17306089.8
<151>  2017-08-23

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA 5' UTR

<400>  1
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca cc               52


<210>  2
<211>  52
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA 5' UTR

<400>  2
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca cc               52


<210>  3
<211>  145
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB 5' UTR

<400>  3
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagcc                                            145


<210>  4
<211>  145
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB 5' UTR

<400>  4
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagcc                                            145


<210>  5
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Alternative Mod 5' UTR

<400>  5
agacgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca cc               52


<210>  6
<211>  52
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Alternative Mod 5' UTR

<400>  6
agacgaacua guauucuucu gguccccaca gacucagaga gaacccgcca cc               52


<210>  7
<211>  427
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA/B 3' UTR

<400>  7
ctcgagctgg tactgcatgc acgcaatgct agctgcccct ttcccgtcct gggtaccccg       60

agtctccccc gacctcgggt cccaggtatg ctcccacctc cacctgcccc actcaccacc      120

tctgctagtt ccagacacct cccaagcacg cagcaatgca gctcaaaacg cttagcctag      180

ccacaccccc acgggaaaca gcagtgatta acctttagca ataaacgaaa gtttaactaa      240

gctatactaa ccccagggtt ggtcaatttc gtgccagcca caccgagacc tggtccagag      300

tcgctagccg cgtcgctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagca tatgactaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaa                                                                427


<210>  8
<211>  427
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA/B 3' UTR

<400>  8
cucgagcugg uacugcaugc acgcaaugcu agcugccccu uucccguccu ggguaccccg       60

agucuccccc gaccucgggu cccagguaug cucccaccuc caccugcccc acucaccacc      120

ucugcuaguu ccagacaccu cccaagcacg cagcaaugca gcucaaaacg cuuagccuag      180

ccacaccccc acgggaaaca gcagugauua accuuuagca auaaacgaaa guuuaacuaa      240

gcuauacuaa ccccaggguu ggucaauuuc gugccagcca caccgagacc ugguccagag      300

ucgcuagccg cgucgcuaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagca uaugacuaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaa                                                                427


<210>  9
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  10
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  10
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt gatga                      465


<210>  11
<211>  465
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human optimized IL-2

<400>  11
atgtacagaa tgcagctgct gtcttgcatt gctctttctc ttgctcttgt gacaaattct       60

gctccaacat cttcttcaac aaagaaaaca cagcttcagc ttgaacacct tcttcttgat      120

cttcagatga ttctgaatgg aatcaacaat tacaaaaatc caaaactgac aagaatgctg      180

acatttaaat tttacatgcc aaagaaagca acagaactga aacaccttca gtgccttgaa      240

gaagaactga aacctctgga agaagtgctg aatctggctc agagcaaaaa ttttcacctg      300

agaccaagag atctgatcag caacatcaat gtgattgtgc tggaactgaa aggatctgaa      360

acaacattca tgtgtgaata tgctgatgaa acagcaacaa ttgtggaatt tctgaacaga      420

tggatcacat tttgccagtc aatcatttca acactgacat gatga                      465


<210>  12
<211>  465
<212>  RNA
<213>  Homo sapiens

<400>  12
auguacagga ugcaacuccu gucuugcauu gcacuaaguc uugcacuugu cacaaacagu       60

gcaccuacuu caaguucuac aaagaaaaca cagcuacaac uggagcauuu acugcuggau      120

uuacagauga uuuugaaugg aauuaauaau uacaagaauc ccaaacucac caggaugcuc      180

acauuuaagu uuuacaugcc caagaaggcc acagaacuga aacaucuuca gugucuagaa      240

gaagaacuca aaccucugga ggaagugcua aauuuagcuc aaagcaaaaa cuuucacuua      300

agacccaggg acuuaaucag caauaucaac guaauaguuc uggaacuaaa gggaucugaa      360

acaacauuca ugugugaaua ugcugaugag acagcaacca uuguagaauu ucugaacaga      420

uggauuaccu uuugucaaag caucaucuca acacugacuu gauga                      465


<210>  13
<211>  465
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human optimized IL-2

<400>  13
auguacagaa ugcagcugcu gucuugcauu gcucuuucuc uugcucuugu gacaaauucu       60

gcuccaacau cuucuucaac aaagaaaaca cagcuucagc uugaacaccu ucuucuugau      120

cuucagauga uucugaaugg aaucaacaau uacaaaaauc caaaacugac aagaaugcug      180

acauuuaaau uuuacaugcc aaagaaagca acagaacuga aacaccuuca gugccuugaa      240

gaagaacuga aaccucugga agaagugcug aaucuggcuc agagcaaaaa uuuucaccug      300

agaccaagag aucugaucag caacaucaau gugauugugc uggaacugaa aggaucugaa      360

acaacauuca ugugugaaua ugcugaugaa acagcaacaa uuguggaauu ucugaacaga      420

uggaucacau uuugccaguc aaucauuuca acacugacau gauga                      465


<210>  14
<211>  539
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human IL-12sc

<400>  14

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Pro Gly Gly Gly Ser Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 


<210>  15
<211>  1623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human non-optimized IL-12sc

<400>  15
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

gggtcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagtggctct agcggagggg gaggctctcc tggcggggga     1020

tctagcagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac     1080

tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa     1140

ttttaccctt gcacttctga ggaaattgat catgaagata tcacaaaaga taaaaccagc     1200

acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga     1260

gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg     1320

gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc     1380

atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg     1440

gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa     1500

tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat     1560

gctttcagaa ttcgggcagt gactattgat agagtgatga gctatctgaa tgcttcctga     1620

tga                                                                   1623


<210>  16
<211>  1623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human optimized IL-12sc

<400>  16
atgtgtcacc agcagctggt gatctcatgg ttctccctgg tatttctggc atctcctctt       60

gtcgcaatct gggaactgaa gaaagacgtg tatgtcgttg agctcgactg gtatccggat      120

gcgcctggcg agatggtggt gctgacctgt gacaccccag aggaggatgg gatcacttgg      180

acccttgatc aatcctccga agtgctcggg tctggcaaga ctctgaccat acaagtgaaa      240

gagtttggcg atgccgggca gtacacttgc cataagggcg gagaagttct gtcccactca      300

ctgctgctgc tgcacaagaa agaggacgga atttggagta ccgatatcct gaaagatcag      360

aaagagccca agaacaaaac cttcttgcgg tgcgaagcca agaactactc agggagattt      420

acttgttggt ggctgacgac gatcagcacc gatctgactt tctccgtgaa atcaagtagg      480

ggatcatctg accctcaagg agtcacatgt ggagcggcta ctctgagcgc tgaacgcgta      540

agaggggaca ataaggagta cgagtatagc gttgagtgcc aagaggatag cgcatgcccc      600

gccgccgaag aatcattgcc cattgaagtg atggtggatg ctgtacacaa gctgaagtat      660

gagaactaca caagctcctt cttcatccgt gacatcatca aaccagatcc tcctaagaac      720

ctccagctta aacctctgaa gaactctaga caggtggaag tgtcttggga gtatcccgac      780

acctggtcta caccacattc ctacttcagt ctcacattct gcgttcaggt acagggcaag      840

tccaaaaggg agaagaagga tcgggtcttt acagataaaa caagtgccac cgttatatgc      900

cggaagaatg cctctatttc tgtgcgtgcg caggacagat actatagcag ctcttggagt      960

gaatgggcca gtgtcccatg ttcagggtca tccggtggtg gcggcagccc cggaggcggt     1020

agctccagaa atctccctgt ggctacacct gatccaggca tgtttccctg tttgcaccat     1080

agccaaaacc tcctgagagc agtcagcaac atgctccaga aagctagaca aacactggaa     1140

ttctacccat gcacctccga ggaaatagat cacgaggata tcactaagga caaaacaagc     1200

actgtcgaag catgccttcc cttggaactg acaaagaacg agagttgcct taattcaaga     1260

gaaacatctt tcattacaaa cggtagctgc ttggcaagca gaaaaacatc ttttatgatg     1320

gccctttgtc tgagcagtat ttatgaggat ctcaaaatgt accaggtgga gtttaagacc     1380

atgaatgcca agctgctgat ggacccaaag agacagattt tcctcgatca gaatatgctg     1440

gctgtgattg atgaactgat gcaggccttg aatttcaaca gcgaaaccgt tccccagaaa     1500

agcagtcttg aagaacctga cttttataag accaagatca aactgtgtat tctcctgcat     1560

gcctttagaa tcagagcagt cactatagat agagtgatgt cctacctgaa tgcttcctga     1620

tga                                                                   1623


<210>  17
<211>  1623
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human non-optimized IL-12sc

<400>  17
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

gggucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguggcucu agcggagggg gaggcucucc uggcggggga     1020

ucuagcagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac     1080

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa     1140

uuuuacccuu gcacuucuga ggaaauugau caugaagaua ucacaaaaga uaaaaccagc     1200

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga     1260

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug     1320

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc     1380

augaaugcaa agcuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug     1440

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa     1500

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau     1560

gcuuucagaa uucgggcagu gacuauugau agagugauga gcuaucugaa ugcuuccuga     1620

uga                                                                   1623


<210>  18
<211>  1623
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human optimized IL-12sc

<400>  18
augugucacc agcagcuggu gaucucaugg uucucccugg uauuucuggc aucuccucuu       60

gucgcaaucu gggaacugaa gaaagacgug uaugucguug agcucgacug guauccggau      120

gcgccuggcg agaugguggu gcugaccugu gacaccccag aggaggaugg gaucacuugg      180

acccuugauc aauccuccga agugcucggg ucuggcaaga cucugaccau acaagugaaa      240

gaguuuggcg augccgggca guacacuugc cauaagggcg gagaaguucu gucccacuca      300

cugcugcugc ugcacaagaa agaggacgga auuuggagua ccgauauccu gaaagaucag      360

aaagagccca agaacaaaac cuucuugcgg ugcgaagcca agaacuacuc agggagauuu      420

acuuguuggu ggcugacgac gaucagcacc gaucugacuu ucuccgugaa aucaaguagg      480

ggaucaucug acccucaagg agucacaugu ggagcggcua cucugagcgc ugaacgcgua      540

agaggggaca auaaggagua cgaguauagc guugagugcc aagaggauag cgcaugcccc      600

gccgccgaag aaucauugcc cauugaagug augguggaug cuguacacaa gcugaaguau      660

gagaacuaca caagcuccuu cuucauccgu gacaucauca aaccagaucc uccuaagaac      720

cuccagcuua aaccucugaa gaacucuaga cagguggaag ugucuuggga guaucccgac      780

accuggucua caccacauuc cuacuucagu cucacauucu gcguucaggu acagggcaag      840

uccaaaaggg agaagaagga ucgggucuuu acagauaaaa caagugccac cguuauaugc      900

cggaagaaug ccucuauuuc ugugcgugcg caggacagau acuauagcag cucuuggagu      960

gaaugggcca gugucccaug uucaggguca uccgguggug gcggcagccc cggaggcggu     1020

agcuccagaa aucucccugu ggcuacaccu gauccaggca uguuucccug uuugcaccau     1080

agccaaaacc uccugagagc agucagcaac augcuccaga aagcuagaca aacacuggaa     1140

uucuacccau gcaccuccga ggaaauagau cacgaggaua ucacuaagga caaaacaagc     1200

acugucgaag caugccuucc cuuggaacug acaaagaacg agaguugccu uaauucaaga     1260

gaaacaucuu ucauuacaaa cgguagcugc uuggcaagca gaaaaacauc uuuuaugaug     1320

gcccuuuguc ugagcaguau uuaugaggau cucaaaaugu accaggugga guuuaagacc     1380

augaaugcca agcugcugau ggacccaaag agacagauuu uccucgauca gaauaugcug     1440

gcugugauug augaacugau gcaggccuug aauuucaaca gcgaaaccgu uccccagaaa     1500

agcagucuug aagaaccuga cuuuuauaag accaagauca aacuguguau ucuccugcau     1560

gccuuuagaa ucagagcagu cacuauagau agagugaugu ccuaccugaa ugcuuccuga     1620

uga                                                                   1623


<210>  19
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  20
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  20
atggccttga cctttgcttt actggtggcc ctcctggtgc tcagctgcaa gtcaagctgc       60

tctgtgggct gtgatctgcc tcaaacccac agcctgggta gcaggaggac cttgatgctc      120

ctggcacaga tgaggagaat ctctcttttc tcctgcttga aggacagaca tgactttgga      180

tttccccagg aggagtttgg caaccagttc caaaaggctg aaaccatccc tgtcctccat      240

gagatgatcc agcagatctt caaccttttc agcacaaagg actcatctgc tgcttgggat      300

gagaccctcc tagacaaatt ctacactgaa ctctaccagc agctgaatga cctggaagcc      360

tgtgtgatac agggggtggg ggtgacagag actcccctga tgaaggagga ctccattctg      420

gctgtgagga aatacttcca aagaatcact ctctatctga aagagaagaa atacagccct      480

tgtgcctggg aggttgtcag agcagaaatc atgagatctt tttctttgtc aacaaacttg      540

caagaaagtt taagaagtaa ggaatgatga                                       570


<210>  21
<211>  570
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human optimized IFN-alpha-2b

<400>  21
atggccctga cttttgccct tctcgtggct ttgttggtgc tgagttgcaa atcttcctgt       60

agtgtcggat gtgatctgcc tcaaacccac agtctgggat ctaggagaac actgatgctg      120

ttggcacaga tgaggagaat tagcctcttt tcctgcctga aggatagaca tgacttcggc      180

tttccccaag aggagtttgg caatcagttc cagaaagcgg aaacgattcc cgttctgcac      240

gagatgatcc agcagatctt caacctcttt tcaaccaaag acagctcagc agcctgggat      300

gagacactgc tggacaaatt ctacacagaa ctgtatcagc agcttaacga tctggaggca      360

tgcgtgatcc aaggggttgg tgtgactgaa actccgctta tgaaggagga ctccattctg      420

gctgtacgga agtacttcca gagaataacc ctctatctga aggagaagaa gtactcacca      480

tgtgcttggg aagtcgtgag agccgaaatc atgagatcct tcagccttag caccaatctc      540

caggaatctc tgagaagcaa agagtgatga                                       570


<210>  22
<211>  570
<212>  RNA
<213>  Homo sapiens

<400>  22
auggccuuga ccuuugcuuu acugguggcc cuccuggugc ucagcugcaa gucaagcugc       60

ucugugggcu gugaucugcc ucaaacccac agccugggua gcaggaggac cuugaugcuc      120

cuggcacaga ugaggagaau cucucuuuuc uccugcuuga aggacagaca ugacuuugga      180

uuuccccagg aggaguuugg caaccaguuc caaaaggcug aaaccauccc uguccuccau      240

gagaugaucc agcagaucuu caaccuuuuc agcacaaagg acucaucugc ugcuugggau      300

gagacccucc uagacaaauu cuacacugaa cucuaccagc agcugaauga ccuggaagcc      360

ugugugauac aggggguggg ggugacagag acuccccuga ugaaggagga cuccauucug      420

gcugugagga aauacuucca aagaaucacu cucuaucuga aagagaagaa auacagcccu      480

ugugccuggg agguugucag agcagaaauc augagaucuu uuucuuuguc aacaaacuug      540

caagaaaguu uaagaaguaa ggaaugauga                                       570


<210>  23
<211>  570
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human optimized IFN-alpha-2b

<400>  23
auggcccuga cuuuugcccu ucucguggcu uuguuggugc ugaguugcaa aucuuccugu       60

agugucggau gugaucugcc ucaaacccac agucugggau cuaggagaac acugaugcug      120

uuggcacaga ugaggagaau uagccucuuu uccugccuga aggauagaca ugacuucggc      180

uuuccccaag aggaguuugg caaucaguuc cagaaagcgg aaacgauucc cguucugcac      240

gagaugaucc agcagaucuu caaccucuuu ucaaccaaag acagcucagc agccugggau      300

gagacacugc uggacaaauu cuacacagaa cuguaucagc agcuuaacga ucuggaggca      360

ugcgugaucc aagggguugg ugugacugaa acuccgcuua ugaaggagga cuccauucug      420

gcuguacgga aguacuucca gagaauaacc cucuaucuga aggagaagaa guacucacca      480

ugugcuuggg aagucgugag agccgaaauc augagauccu ucagccuuag caccaaucuc      540

caggaaucuc ugagaagcaa agagugauga                                       570


<210>  24
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human IL-15 sushi

<400>  24

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn 
        115                 120                 125             


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
    130                 135                 140                 


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
145                 150                 155                 160 


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
                165                 170                 175     


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
            180                 185                 190         


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
        195                 200                 205             


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
    210                 215                 220                 


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
225                 230                 235                 240 


Ser 
    


<210>  25
<211>  729
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human IL-15 sushi

<400>  25
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa      120

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      180

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      240

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      300

caccaaaggc cagcgccacc cgggggagga tctggcggcg gtgggtctgg cgggggatct      360

ggcggaggag gaagcttaca gaactgggtg aatgtaataa gtgatttgaa aaaaattgaa      420

gatcttattc aatctatgca tattgatgct actttatata cggaaagtga tgttcacccc      480

agttgcaaag taacagcaat gaagtgcttt ctcttggagt tacaagttat ttcacttgag      540

tccggagatg caagtattca tgatacagta gaaaatctga tcatcctagc aaacaacagt      600

ttgtcttcta atgggaatgt aacagaatct ggatgcaaag aatgtgagga actggaggaa      660

aaaaatatta aagaattttt gcagagtttt gtacatattg tccaaatgtt catcaacact      720

tcttgatga                                                              729


<210>  26
<211>  729
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human IL-15 sushi

<400>  26
auggccccgc ggcgggcgcg cggcugccgg acccucgguc ucccggcgcu gcuacugcug       60

cugcugcucc ggccgccggc gacgcggggc aucacgugcc cuccccccau guccguggaa      120

cacgcagaca ucugggucaa gagcuacagc uuguacucca gggagcggua cauuuguaac      180

ucugguuuca agcguaaagc cggcacgucc agccugacgg agugcguguu gaacaaggcc      240

acgaaugucg cccacuggac aacccccagu cucaaaugca uuagagaccc ugcccugguu      300

caccaaaggc cagcgccacc cgggggagga ucuggcggcg gugggucugg cgggggaucu      360

ggcggaggag gaagcuuaca gaacugggug aauguaauaa gugauuugaa aaaaauugaa      420

gaucuuauuc aaucuaugca uauugaugcu acuuuauaua cggaaaguga uguucacccc      480

aguugcaaag uaacagcaau gaagugcuuu cucuuggagu uacaaguuau uucacuugag      540

uccggagaug caaguauuca ugauacagua gaaaaucuga ucauccuagc aaacaacagu      600

uugucuucua augggaaugu aacagaaucu ggaugcaaag aaugugagga acuggaggaa      660

aaaaauauua aagaauuuuu gcagaguuuu guacauauug uccaaauguu caucaacacu      720

ucuugauga                                                              729


<210>  27
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  28
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  28
atgtggctcc agagcctgct gctcttgggc actgtggcct gctccatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctgctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtgatga                                                    438


<210>  29
<211>  438
<212>  RNA
<213>  Homo sapiens

<400>  29
auguggcucc agagccugcu gcucuugggc acuguggccu gcuccaucuc ugcacccgcc       60

cgcucgccca gccccagcac gcagcccugg gagcauguga augccaucca ggaggcccgg      120

cgucugcuga accugaguag agacacugcu gcugagauga augaaacagu agaagucauc      180

ucagaaaugu uugaccucca ggagccgacc ugccuacaga cccgccugga gcuguacaag      240

cagggccugc ggggcagccu caccaagcuc aagggccccu ugaccaugau ggccagccac      300

uacaagcagc acugcccucc aaccccggaa acuuccugug caacccagau uaucaccuuu      360

gaaaguuuca aagagaaccu gaaggacuuu cugcuuguca uccccuuuga cugcugggag      420

ccaguccagg agugauga                                                    438


<210>  30
<211>  161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA IL-2 (human IL-2 in combination with a mouse optimized 
       secretion sequence)

<400>  30

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Gly Ser Ala Pro Thr Ser 
            20                  25                  30          


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
        35                  40                  45              


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
    50                  55                  60                  


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
65                  70                  75                  80  


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
                85                  90                  95      


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
            100                 105                 110         


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
        115                 120                 125             


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
    130                 135                 140                 


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
145                 150                 155                 160 


Thr 
    


<210>  31
<211>  959
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA IL-2 (5'UTR-CDS-3'UTR)

<400>  31
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgagagt       60

gaccgccccc agaaccctga tcctgctgct gtctggcgcc ctggccctga cagagacatg      120

ggccggaagc ggatccgcac ctacttcaag ttctacaaag aaaacacagc tacaactgga      180

gcatttactt ctggatttac agatgatttt gaatggaatt aataattaca agaatcccaa      240

actcaccagg atgctcacat ttaagtttta catgcccaag aaggccacag aactgaaaca      300

tcttcagtgt ctagaagaag aactcaaacc tctggaggaa gtgctaaatt tagctcaaag      360

caaaaacttt cacttaagac ccagggactt aatcagcaat atcaacgtaa tagttctgga      420

actaaaggga tctgaaacaa cattcatgtg tgaatatgct gatgagacag caaccattgt      480

agaatttctg aacagatgga ttaccttttg tcaaagcatc atctcaacac tgacttgact      540

cgagagctcg ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca      600

actactaaac tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa      660

acatttattt tcattgctgc gtcgagagct cgctttcttg ctgtccaatt tctattaaag      720

gttcctttgt tccctaagtc caactactaa actgggggat attatgaagg gccttgagca      780

tctggattct gcctaataaa aaacatttat tttcattgct gcgtcgagac ctggtccaga      840

gtcgctagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaag catatgacta aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa       959


<210>  32
<211>  959
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA IL-2

<400>  32
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc ggauccgcac cuacuucaag uucuacaaag aaaacacagc uacaacugga      180

gcauuuacuu cuggauuuac agaugauuuu gaauggaauu aauaauuaca agaaucccaa      240

acucaccagg augcucacau uuaaguuuua caugcccaag aaggccacag aacugaaaca      300

ucuucagugu cuagaagaag aacucaaacc ucuggaggaa gugcuaaauu uagcucaaag      360

caaaaacuuu cacuuaagac ccagggacuu aaucagcaau aucaacguaa uaguucugga      420

acuaaaggga ucugaaacaa cauucaugug ugaauaugcu gaugagacag caaccauugu      480

agaauuucug aacagaugga uuaccuuuug ucaaagcauc aucucaacac ugacuugacu      540

cgagagcucg cuuucuugcu guccaauuuc uauuaaaggu uccuuuguuc ccuaagucca      600

acuacuaaac ugggggauau uaugaagggc cuugagcauc uggauucugc cuaauaaaaa      660

acauuuauuu ucauugcugc gucgagagcu cgcuuucuug cuguccaauu ucuauuaaag      720

guuccuuugu ucccuaaguc caacuacuaa acugggggau auuaugaagg gccuugagca      780

ucuggauucu gccuaauaaa aaacauuuau uuucauugcu gcgucgagac cugguccaga      840

gucgcuagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaag cauaugacua aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa       959


<210>  33
<211>  161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB IL-2

<400>  33

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Ala Pro Thr Ser 
            20                  25                  30          


Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp 
        35                  40                  45              


Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu 
    50                  55                  60                  


Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu 
65                  70                  75                  80  


Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu 
                85                  90                  95      


Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp 
            100                 105                 110         


Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu 
        115                 120                 125             


Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu 
    130                 135                 140                 


Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu 
145                 150                 155                 160 


Thr 
    


<210>  34
<211>  1039
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB IL-2 (5'UTR-CDS-3'UTR)

<400>  34
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatccg cacctacttc      240

aagttctaca aagaaaacac agctacaact ggagcattta cttctggatt tacagatgat      300

tttgaatgga attaataatt acaagaatcc caaactcacc aggatgctca catttaagtt      360

ttacatgccc aagaaggcca cagaactgaa acatcttcag tgtctagaag aagaactcaa      420

acctctggag gaagtgctaa atttagctca aagcaaaaac tttcacttaa gacccaggga      480

cttaatcagc aatatcaacg taatagttct ggaactaaag ggatctgaaa caacattcat      540

gtgtgaatat gctgatgaga cagcaaccat tgtagaattt ctgaacagat ggattacctt      600

ttgtcaaagc atcatctcaa cactgacttg actcgacgtc ctggtactgc atgcacgcaa      660

tgctagctgc ccctttcccg tcctgggtac cccgagtctc ccccgacctc gggtcccagg      720

tatgctccca cctccacctg ccccactcac cacctctgct agttccagac acctcccaag      780

cacgcagcaa tgcagctcaa aacgcttagc ctagccacac ccccacggga aacagcagtg      840

attaaccttt agcaataaac gaaagtttaa ctaagctata ctaaccccag ggttggtcaa      900

tttcgtgcca gccacaccct cgagctagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaag      960

catatgacta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaa                                                  1039


<210>  35
<211>  1039
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB IL-2

<400>  35
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggauccg caccuacuuc      240

aaguucuaca aagaaaacac agcuacaacu ggagcauuua cuucuggauu uacagaugau      300

uuugaaugga auuaauaauu acaagaaucc caaacucacc aggaugcuca cauuuaaguu      360

uuacaugccc aagaaggcca cagaacugaa acaucuucag ugucuagaag aagaacucaa      420

accucuggag gaagugcuaa auuuagcuca aagcaaaaac uuucacuuaa gacccaggga      480

cuuaaucagc aauaucaacg uaauaguucu ggaacuaaag ggaucugaaa caacauucau      540

gugugaauau gcugaugaga cagcaaccau uguagaauuu cugaacagau ggauuaccuu      600

uugucaaagc aucaucucaa cacugacuug acucgacguc cugguacugc augcacgcaa      660

ugcuagcugc cccuuucccg uccuggguac cccgagucuc ccccgaccuc gggucccagg      720

uaugcuccca ccuccaccug ccccacucac caccucugcu aguuccagac accucccaag      780

cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac ccccacggga aacagcagug      840

auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua cuaaccccag gguuggucaa      900

uuucgugcca gccacacccu cgagcuagca aaaaaaaaaa aaaaaaaaaa aaaaaaaaag      960

cauaugacua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaa                                                  1039


<210>  36
<211>  544
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine IL-12

<400>  36

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Gly Ser Met Trp Glu Leu 
            20                  25                  30          


Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro 
        35                  40                  45              


Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile 
    50                  55                  60                  


Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr 
65                  70                  75                  80  


Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys 
                85                  90                  95      


His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys 
            100                 105                 110         


Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn 
        115                 120                 125             


Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr 
    130                 135                 140                 


Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 
                165                 170                 175     


Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys 
            180                 185                 190         


Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu 
        195                 200                 205             


Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr 
    210                 215                 220                 


Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
225                 230                 235                 240 


Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 
                245                 250                 255     


Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe 
            260                 265                 270         


Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys 
        275                 280                 285             


Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys 
    290                 295                 300                 


Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala 
305                 310                 315                 320 


Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro 
                325                 330                 335     


Cys Arg Val Arg Ser Val Pro Gly Val Gly Val Pro Gly Val Gly Arg 
            340                 345                 350         


Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn 
        355                 360                 365             


Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu 
    370                 375                 380                 


Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr 
385                 390                 395                 400 


Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His 
                405                 410                 415     


Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg 
            420                 425                 430         


Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys 
        435                 440                 445             


Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln 
    450                 455                 460                 


Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu 
465                 470                 475                 480 


Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn 
                485                 490                 495     


His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp 
            500                 505                 510         


Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser 
        515                 520                 525             


Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    530                 535                 540                 


<210>  37
<211>  2111
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine IL-12 (5'UTR-CDS-3'UTR)

<400>  37
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgagagt       60

gaccgccccc agaaccctga tcctgctgct gtctggcgcc ctggccctga cagagacatg      120

ggccggaagc ggatccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg      180

gactcccgat gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga      240

catcacctgg acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat      300

cactgtcaaa gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct      360

gagccactca catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt      420

aaaaaatttc aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt      480

cacgtgctca tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag      540

cagttcccct gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt      600

cacactggac caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg      660

cccaactgcc gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa      720

atatgagaac tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa      780

gaacttgcag atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga      840

ctcctggagc actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa      900

gaaagaaaag atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga      960

gaagacatct accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg     1020

ctattacaat tcctcatgca gcaagtgggc atgtgttccc tgcagagtcc gatcggttcc     1080

tggagtaggg gtacctggag tgggcagggt cataccggtc tctggacctg ccaggtgtct     1140

tagccagtcc cgaaacctgc tgaagaccac agatgacatg gtgaagacgg ccagagaaaa     1200

gctgaaacat tattcctgca ctgctgaaga catcgatcat gaagacatca cacgggacca     1260

aaccagcaca ttgaagacct gtttaccact ggaactacac aagaacgaga gttgcctggc     1320

tactagagag acttcttcca caacaagagg gagctgcctg cccccacaga agacgtcttt     1380

gatgatgacc ctgtgccttg gtagcatcta tgaggacttg aagatgtacc agacagagtt     1440

ccaggccatc aacgcagcac ttcagaatca caaccatcag cagatcattc tagacaaggg     1500

catgctggtg gccatcgatg agctgatgca gtctctgaat cataatggcg agactctgcg     1560

ccagaaacct cctgtgggag aagcagaccc ttacagagtg aaaatgaagc tctgcatcct     1620

gcttcacgcc ttcagcaccc gcgtcgtgac catcaacagg gtgatgggct atctgtccag     1680

cgcctaatag ctcgagagct cgctttcttg ctgtccaatt tctattaaag gttcctttgt     1740

tccctaagtc caactactaa actgggggat attatgaagg gccttgagca tctggattct     1800

gcctaataaa aaacatttat tttcattgct gcgtcgagag ctcgctttct tgctgtccaa     1860

tttctattaa aggttccttt gttccctaag tccaactact aaactggggg atattatgaa     1920

gggccttgag catctggatt ctgcctaata aaaaacattt attttcattg ctgcgtcgag     1980

acctggtcca gagtcgctag caaaaaaaaa aaaaaaaaaa aaaaaaaaaa agcatatgac     2040

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa a                                                          2111


<210>  38
<211>  2111
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine IL-12

<400>  38
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc ggauccaugu gggagcugga gaaagacguu uauguuguag agguggacug      180

gacucccgau gccccuggag aaacagugaa ccucaccugu gacacgccug aagaagauga      240

caucaccugg accucagacc agagacaugg agucauaggc ucuggaaaga cccugaccau      300

cacugucaaa gaguuucuag augcuggcca guacaccugc cacaaaggag gcgagacucu      360

gagccacuca caucugcugc uccacaagaa ggaaaaugga auuuggucca cugaaauuuu      420

aaaaaauuuc aaaaacaaga cuuuccugaa gugugaagca ccaaauuacu ccggacgguu      480

cacgugcuca uggcuggugc aaagaaacau ggacuugaag uucaacauca agagcaguag      540

caguuccccu gacucucggg cagugacaug uggaauggcg ucucugucug cagagaaggu      600

cacacuggac caaagggacu augagaagua uucagugucc ugccaggagg augucaccug      660

cccaacugcc gaggagaccc ugcccauuga acuggcguug gaagcacggc agcagaauaa      720

auaugagaac uacagcacca gcuucuucau cagggacauc aucaaaccag acccgcccaa      780

gaacuugcag augaagccuu ugaagaacuc acagguggag gucagcuggg aguacccuga      840

cuccuggagc acuccccauu ccuacuucuc ccucaaguuc uuuguucgaa uccagcgcaa      900

gaaagaaaag augaaggaga cagaggaggg guguaaccag aaaggugcgu uccucguaga      960

gaagacaucu accgaagucc aaugcaaagg cgggaauguc ugcgugcaag cucaggaucg     1020

cuauuacaau uccucaugca gcaagugggc auguguuccc ugcagagucc gaucgguucc     1080

uggaguaggg guaccuggag ugggcagggu cauaccgguc ucuggaccug ccaggugucu     1140

uagccagucc cgaaaccugc ugaagaccac agaugacaug gugaagacgg ccagagaaaa     1200

gcugaaacau uauuccugca cugcugaaga caucgaucau gaagacauca cacgggacca     1260

aaccagcaca uugaagaccu guuuaccacu ggaacuacac aagaacgaga guugccuggc     1320

uacuagagag acuucuucca caacaagagg gagcugccug cccccacaga agacgucuuu     1380

gaugaugacc cugugccuug guagcaucua ugaggacuug aagauguacc agacagaguu     1440

ccaggccauc aacgcagcac uucagaauca caaccaucag cagaucauuc uagacaaggg     1500

caugcuggug gccaucgaug agcugaugca gucucugaau cauaauggcg agacucugcg     1560

ccagaaaccu ccugugggag aagcagaccc uuacagagug aaaaugaagc ucugcauccu     1620

gcuucacgcc uucagcaccc gcgucgugac caucaacagg gugaugggcu aucuguccag     1680

cgccuaauag cucgagagcu cgcuuucuug cuguccaauu ucuauuaaag guuccuuugu     1740

ucccuaaguc caacuacuaa acugggggau auuaugaagg gccuugagca ucuggauucu     1800

gccuaauaaa aaacauuuau uuucauugcu gcgucgagag cucgcuuucu ugcuguccaa     1860

uuucuauuaa agguuccuuu guucccuaag uccaacuacu aaacuggggg auauuaugaa     1920

gggccuugag caucuggauu cugccuaaua aaaaacauuu auuuucauug cugcgucgag     1980

accuggucca gagucgcuag caaaaaaaaa aaaaaaaaaa aaaaaaaaaa agcauaugac     2040

uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa a                                                          2111


<210>  39
<211>  544
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine IL-12

<400>  39

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Met Trp Glu Leu 
            20                  25                  30          


Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro 
        35                  40                  45              


Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile 
    50                  55                  60                  


Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr 
65                  70                  75                  80  


Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys 
                85                  90                  95      


His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys 
            100                 105                 110         


Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn 
        115                 120                 125             


Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr 
    130                 135                 140                 


Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 
                165                 170                 175     


Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys 
            180                 185                 190         


Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu 
        195                 200                 205             


Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr 
    210                 215                 220                 


Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
225                 230                 235                 240 


Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 
                245                 250                 255     


Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe 
            260                 265                 270         


Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys 
        275                 280                 285             


Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys 
    290                 295                 300                 


Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala 
305                 310                 315                 320 


Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro 
                325                 330                 335     


Cys Arg Val Arg Ser Val Pro Gly Val Gly Val Pro Gly Val Gly Arg 
            340                 345                 350         


Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn 
        355                 360                 365             


Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu 
    370                 375                 380                 


Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr 
385                 390                 395                 400 


Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His 
                405                 410                 415     


Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg 
            420                 425                 430         


Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys 
        435                 440                 445             


Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln 
    450                 455                 460                 


Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu 
465                 470                 475                 480 


Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn 
                485                 490                 495     


His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp 
            500                 505                 510         


Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser 
        515                 520                 525             


Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
    530                 535                 540                 


<210>  40
<211>  2191
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine IL-12 (5'UTR-CDS-3'UTR)

<400>  40
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatcca tgtgggagct      240

ggagaaagac gtttatgttg tagaggtgga ctggactccc gatgcccctg gagaaacagt      300

gaacctcacc tgtgacacgc ctgaagaaga tgacatcacc tggacctcag accagagaca      360

tggagtcata ggctctggaa agaccctgac catcactgtc aaagagtttc tagatgctgg      420

ccagtacacc tgccacaaag gaggcgagac tctgagccac tcacatctgc tgctccacaa      480

gaaggaaaat ggaatttggt ccactgaaat tttaaaaaat ttcaaaaaca agactttcct      540

gaagtgtgaa gcaccaaatt actccggacg gttcacgtgc tcatggctgg tgcaaagaaa      600

catggacttg aagttcaaca tcaagagcag tagcagttcc cctgactctc gggcagtgac      660

atgtggaatg gcgtctctgt ctgcagagaa ggtcacactg gaccaaaggg actatgagaa      720

gtattcagtg tcctgccagg aggatgtcac ctgcccaact gccgaggaga ccctgcccat      780

tgaactggcg ttggaagcac ggcagcagaa taaatatgag aactacagca ccagcttctt      840

catcagggac atcatcaaac cagacccgcc caagaacttg cagatgaagc ctttgaagaa      900

ctcacaggtg gaggtcagct gggagtaccc tgactcctgg agcactcccc attcctactt      960

ctccctcaag ttctttgttc gaatccagcg caagaaagaa aagatgaagg agacagagga     1020

ggggtgtaac cagaaaggtg cgttcctcgt agagaagaca tctaccgaag tccaatgcaa     1080

aggcgggaat gtctgcgtgc aagctcagga tcgctattac aattcctcat gcagcaagtg     1140

ggcatgtgtt ccctgcagag tccgatcggt tcctggagta ggggtacctg gagtgggcag     1200

ggtcataccg gtctctggac ctgccaggtg tcttagccag tcccgaaacc tgctgaagac     1260

cacagatgac atggtgaaga cggccagaga aaagctgaaa cattattcct gcactgctga     1320

agacatcgat catgaagaca tcacacggga ccaaaccagc acattgaaga cctgtttacc     1380

actggaacta cacaagaacg agagttgcct ggctactaga gagacttctt ccacaacaag     1440

agggagctgc ctgcccccac agaagacgtc tttgatgatg accctgtgcc ttggtagcat     1500

ctatgaggac ttgaagatgt accagacaga gttccaggcc atcaacgcag cacttcagaa     1560

tcacaaccat cagcagatca ttctagacaa gggcatgctg gtggccatcg atgagctgat     1620

gcagtctctg aatcataatg gcgagactct gcgccagaaa cctcctgtgg gagaagcaga     1680

cccttacaga gtgaaaatga agctctgcat cctgcttcac gccttcagca cccgcgtcgt     1740

gaccatcaac agggtgatgg gctatctgtc cagcgcctaa tagctcgacg tcctggtact     1800

gcatgcacgc aatgctagct gcccctttcc cgtcctgggt accccgagtc tcccccgacc     1860

tcgggtccca ggtatgctcc cacctccacc tgccccactc accacctctg ctagttccag     1920

acacctccca agcacgcagc aatgcagctc aaaacgctta gcctagccac acccccacgg     1980

gaaacagcag tgattaacct ttagcaataa acgaaagttt aactaagcta tactaacccc     2040

agggttggtc aatttcgtgc cagccacacc ctcgagctag caaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa agcatatgac taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    2191


<210>  41
<211>  2191
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine IL-12

<400>  41
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggaucca ugugggagcu      240

ggagaaagac guuuauguug uagaggugga cuggacuccc gaugccccug gagaaacagu      300

gaaccucacc ugugacacgc cugaagaaga ugacaucacc uggaccucag accagagaca      360

uggagucaua ggcucuggaa agacccugac caucacuguc aaagaguuuc uagaugcugg      420

ccaguacacc ugccacaaag gaggcgagac ucugagccac ucacaucugc ugcuccacaa      480

gaaggaaaau ggaauuuggu ccacugaaau uuuaaaaaau uucaaaaaca agacuuuccu      540

gaagugugaa gcaccaaauu acuccggacg guucacgugc ucauggcugg ugcaaagaaa      600

cauggacuug aaguucaaca ucaagagcag uagcaguucc ccugacucuc gggcagugac      660

auguggaaug gcgucucugu cugcagagaa ggucacacug gaccaaaggg acuaugagaa      720

guauucagug uccugccagg aggaugucac cugcccaacu gccgaggaga cccugcccau      780

ugaacuggcg uuggaagcac ggcagcagaa uaaauaugag aacuacagca ccagcuucuu      840

caucagggac aucaucaaac cagacccgcc caagaacuug cagaugaagc cuuugaagaa      900

cucacaggug gaggucagcu gggaguaccc ugacuccugg agcacucccc auuccuacuu      960

cucccucaag uucuuuguuc gaauccagcg caagaaagaa aagaugaagg agacagagga     1020

gggguguaac cagaaaggug cguuccucgu agagaagaca ucuaccgaag uccaaugcaa     1080

aggcgggaau gucugcgugc aagcucagga ucgcuauuac aauuccucau gcagcaagug     1140

ggcauguguu cccugcagag uccgaucggu uccuggagua gggguaccug gagugggcag     1200

ggucauaccg gucucuggac cugccaggug ucuuagccag ucccgaaacc ugcugaagac     1260

cacagaugac auggugaaga cggccagaga aaagcugaaa cauuauuccu gcacugcuga     1320

agacaucgau caugaagaca ucacacggga ccaaaccagc acauugaaga ccuguuuacc     1380

acuggaacua cacaagaacg agaguugccu ggcuacuaga gagacuucuu ccacaacaag     1440

agggagcugc cugcccccac agaagacguc uuugaugaug acccugugcc uugguagcau     1500

cuaugaggac uugaagaugu accagacaga guuccaggcc aucaacgcag cacuucagaa     1560

ucacaaccau cagcagauca uucuagacaa gggcaugcug guggccaucg augagcugau     1620

gcagucucug aaucauaaug gcgagacucu gcgccagaaa ccuccugugg gagaagcaga     1680

cccuuacaga gugaaaauga agcucugcau ccugcuucac gccuucagca cccgcgucgu     1740

gaccaucaac agggugaugg gcuaucuguc cagcgccuaa uagcucgacg uccugguacu     1800

gcaugcacgc aaugcuagcu gccccuuucc cguccugggu accccgaguc ucccccgacc     1860

ucggguccca gguaugcucc caccuccacc ugccccacuc accaccucug cuaguuccag     1920

acaccuccca agcacgcagc aaugcagcuc aaaacgcuua gccuagccac acccccacgg     1980

gaaacagcag ugauuaaccu uuagcaauaa acgaaaguuu aacuaagcua uacuaacccc     2040

aggguugguc aauuucgugc cagccacacc cucgagcuag caaaaaaaaa aaaaaaaaaa     2100

aaaaaaaaaa agcauaugac uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    2191


<210>  42
<211>  190
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine IFN-alpha-4

<400>  42

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Gly Ser Cys Asp Leu Pro 
            20                  25                  30          


His Thr Tyr Asn Leu Gly Asn Lys Arg Ala Leu Thr Val Leu Glu Glu 
        35                  40                  45              


Met Arg Arg Leu Pro Pro Leu Ser Cys Leu Lys Asp Arg Lys Asp Phe 
    50                  55                  60                  


Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile Gln Lys Ala Gln 
65                  70                  75                  80  


Ala Ile Leu Val Leu Arg Asp Leu Thr Gln Gln Ile Leu Asn Leu Phe 
                85                  90                  95      


Thr Ser Lys Asp Leu Ser Ala Thr Trp Asn Ala Thr Leu Leu Asp Ser 
            100                 105                 110         


Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu Lys Ala Cys Val 
        115                 120                 125             


Met Gln Glu Pro Pro Leu Thr Gln Glu Asp Ser Leu Leu Ala Val Arg 
    130                 135                 140                 


Thr Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Lys Lys Lys His Ser 
145                 150                 155                 160 


Leu Cys Ala Trp Glu Val Ile Arg Ala Glu Val Trp Arg Ala Leu Ser 
                165                 170                 175     


Ser Ser Thr Asn Leu Leu Ala Arg Leu Ser Glu Glu Lys Glu 
            180                 185                 190 


<210>  43
<211>  1049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine IFN-alpha-4 (5'UTR-CDS-3'UTR)

<400>  43
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgagagt       60

gaccgccccc agaaccctga tcctgctgct gtctggcgcc ctggccctga cagagacatg      120

ggccggaagc ggatcctgtg acctgcctca cacttataac ctcgggaaca agagggcctt      180

gacagtcctg gaagaaatga gaagactccc ccctctttcc tgcctgaagg acaggaagga      240

ttttggattc cccttggaga aggtggataa ccaacagatc cagaaggctc aagccatcct      300

tgtgctaaga gatcttaccc agcagatttt gaacctcttc acatcaaaag acttgtctgc      360

tacttggaat gcaactctcc tagactcatt ctgcaatgac ctccatcagc agctcaatga      420

tctcaaagcc tgtgtgatgc aggaacctcc tctgacccag gaagactccc tgctggctgt      480

gaggacatac ttccacagga tcactgtgta cctgagaaag aagaaacaca gcctctgtgc      540

ctgggaggtg atcagagcag aagtctggag agccctctct tcctcaacca acttgctggc      600

aagactgagt gaggagaagg agtgataact cgagagctcg ctttcttgct gtccaatttc      660

tattaaaggt tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc      720

cttgagcatc tggattctgc ctaataaaaa acatttattt tcattgctgc gtcgagagct      780

cgctttcttg ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa      840

actgggggat attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat      900

tttcattgct gcgtcgagac ctggtccaga gtcgctagca aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaag catatgacta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       1049


<210>  44
<211>  1049
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine IFN-alpha-4

<400>  44
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc ggauccugug accugccuca cacuuauaac cucgggaaca agagggccuu      180

gacaguccug gaagaaauga gaagacuccc cccucuuucc ugccugaagg acaggaagga      240

uuuuggauuc cccuuggaga agguggauaa ccaacagauc cagaaggcuc aagccauccu      300

ugugcuaaga gaucuuaccc agcagauuuu gaaccucuuc acaucaaaag acuugucugc      360

uacuuggaau gcaacucucc uagacucauu cugcaaugac cuccaucagc agcucaauga      420

ucucaaagcc ugugugaugc aggaaccucc ucugacccag gaagacuccc ugcuggcugu      480

gaggacauac uuccacagga ucacugugua ccugagaaag aagaaacaca gccucugugc      540

cugggaggug aucagagcag aagucuggag agcccucucu uccucaacca acuugcuggc      600

aagacugagu gaggagaagg agugauaacu cgagagcucg cuuucuugcu guccaauuuc      660

uauuaaaggu uccuuuguuc ccuaagucca acuacuaaac ugggggauau uaugaagggc      720

cuugagcauc uggauucugc cuaauaaaaa acauuuauuu ucauugcugc gucgagagcu      780

cgcuuucuug cuguccaauu ucuauuaaag guuccuuugu ucccuaaguc caacuacuaa      840

acugggggau auuaugaagg gccuugagca ucuggauucu gccuaauaaa aaacauuuau      900

uuucauugcu gcgucgagac cugguccaga gucgcuagca aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaag cauaugacua aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       1049


<210>  45
<211>  190
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine IFN-alpha-4

<400>  45

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Cys Asp Leu Pro 
            20                  25                  30          


His Thr Tyr Asn Leu Gly Asn Lys Arg Ala Leu Thr Val Leu Glu Glu 
        35                  40                  45              


Met Arg Arg Leu Pro Pro Leu Ser Cys Leu Lys Asp Arg Lys Asp Phe 
    50                  55                  60                  


Gly Phe Pro Leu Glu Lys Val Asp Asn Gln Gln Ile Gln Lys Ala Gln 
65                  70                  75                  80  


Ala Ile Leu Val Leu Arg Asp Leu Thr Gln Gln Ile Leu Asn Leu Phe 
                85                  90                  95      


Thr Ser Lys Asp Leu Ser Ala Thr Trp Asn Ala Thr Leu Leu Asp Ser 
            100                 105                 110         


Phe Cys Asn Asp Leu His Gln Gln Leu Asn Asp Leu Lys Ala Cys Val 
        115                 120                 125             


Met Gln Glu Pro Pro Leu Thr Gln Glu Asp Ser Leu Leu Ala Val Arg 
    130                 135                 140                 


Thr Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Lys Lys Lys His Ser 
145                 150                 155                 160 


Leu Cys Ala Trp Glu Val Ile Arg Ala Glu Val Trp Arg Ala Leu Ser 
                165                 170                 175     


Ser Ser Thr Asn Leu Leu Ala Arg Leu Ser Glu Glu Lys Glu 
            180                 185                 190 


<210>  46
<211>  1129
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine IFN-alpha-4 (5'UTR-CDS-3'UTR)

<400>  46
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatcct gtgacctgcc      240

tcacacttat aacctcggga acaagagggc cttgacagtc ctggaagaaa tgagaagact      300

cccccctctt tcctgcctga aggacaggaa ggattttgga ttccccttgg agaaggtgga      360

taaccaacag atccagaagg ctcaagccat ccttgtgcta agagatctta cccagcagat      420

tttgaacctc ttcacatcaa aagacttgtc tgctacttgg aatgcaactc tcctagactc      480

attctgcaat gacctccatc agcagctcaa tgatctcaaa gcctgtgtga tgcaggaacc      540

tcctctgacc caggaagact ccctgctggc tgtgaggaca tacttccaca ggatcactgt      600

gtacctgaga aagaagaaac acagcctctg tgcctgggag gtgatcagag cagaagtctg      660

gagagccctc tcttcctcaa ccaacttgct ggcaagactg agtgaggaga aggagtgata      720

actcgacgtc ctggtactgc atgcacgcaa tgctagctgc ccctttcccg tcctgggtac      780

cccgagtctc ccccgacctc gggtcccagg tatgctccca cctccacctg ccccactcac      840

cacctctgct agttccagac acctcccaag cacgcagcaa tgcagctcaa aacgcttagc      900

ctagccacac ccccacggga aacagcagtg attaaccttt agcaataaac gaaagtttaa      960

ctaagctata ctaaccccag ggttggtcaa tttcgtgcca gccacaccct cgagctagca     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaag catatgacta aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1129


<210>  47
<211>  1129
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine IFN-alpha-4

<400>  47
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggauccu gugaccugcc      240

ucacacuuau aaccucggga acaagagggc cuugacaguc cuggaagaaa ugagaagacu      300

ccccccucuu uccugccuga aggacaggaa ggauuuugga uuccccuugg agaaggugga      360

uaaccaacag auccagaagg cucaagccau ccuugugcua agagaucuua cccagcagau      420

uuugaaccuc uucacaucaa aagacuuguc ugcuacuugg aaugcaacuc uccuagacuc      480

auucugcaau gaccuccauc agcagcucaa ugaucucaaa gccuguguga ugcaggaacc      540

uccucugacc caggaagacu cccugcuggc ugugaggaca uacuuccaca ggaucacugu      600

guaccugaga aagaagaaac acagccucug ugccugggag gugaucagag cagaagucug      660

gagagcccuc ucuuccucaa ccaacuugcu ggcaagacug agugaggaga aggagugaua      720

acucgacguc cugguacugc augcacgcaa ugcuagcugc cccuuucccg uccuggguac      780

cccgagucuc ccccgaccuc gggucccagg uaugcuccca ccuccaccug ccccacucac      840

caccucugcu aguuccagac accucccaag cacgcagcaa ugcagcucaa aacgcuuagc      900

cuagccacac ccccacggga aacagcagug auuaaccuuu agcaauaaac gaaaguuuaa      960

cuaagcuaua cuaaccccag gguuggucaa uuucgugcca gccacacccu cgagcuagca     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaag cauaugacua aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 1129


<210>  48
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine IL-15 sushi

<400>  48

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Thr Thr Cys Pro 
            20                  25                  30          


Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn Tyr Ser 
        35                  40                  45              


Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys Arg Lys 
    50                  55                  60                  


Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn Thr Asn 
65                  70                  75                  80  


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ser 
                85                  90                  95      


Leu Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Ser Gly Gly Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu 
        115                 120                 125             


Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr 
    130                 135                 140                 


Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys 
145                 150                 155                 160 


Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr 
                165                 170                 175     


Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu 
            180                 185                 190         


Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu 
        195                 200                 205             


Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile 
    210                 215                 220                 


Val Gln Met Phe Ile Asn Thr Ser 
225                 230         


<210>  49
<211>  1162
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine IL-15 sushi (5'UTR-CDS-3'UTR)

<400>  49
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgggcgc       60

catggcccct agaacattgc tcctgctgct ggccgctgcc ctggccccta cacagacaag      120

agctggacct ggatccacca cgtgtccacc tcccgtatct attgagcatg ctgacatccg      180

ggtcaagaat tacagtgtga actccaggga gaggtatgtc tgtaactctg gctttaagcg      240

gaaagctgga acatccaccc tgattgagtg tgtgatcaac aagaacacaa atgttgccca      300

ctggacaact cccagcctca agtgcatcag agacccctcc ctagctggag ggagcggagg      360

ctctggcgga agcggcgggt ctggaggctc cgggggaagc ggcggaaatt ggatcgacgt      420

gcgctacgac ctggaaaaga tcgagagcct gatccagagc atccacatcg acaccaccct      480

gtacaccgac agcgacttcc accccagctg caaagtgacc gctatgaact gcttcctgct      540

ggaactgcaa gtgatcctgc acgagtacag caacatgacc ctgaacgaga cagtgcggaa      600

cgtgctgtac ctggccaaca gcaccctgag cagcaacaag aacgtggccg agagcggctg      660

caaagagtgc gaggaactgg aagaaaagac cttcaccgag tttctgcaga gcttcatcag      720

gatcgtgcag atgttcatca acacctcttg atgagtcgac gtcctggtac tgcatgcacg      780

caatgctagc tgcccctttc ccgtcctggg taccccgagt ctcccccgac ctcgggtccc      840

aggtatgctc ccacctccac ctgccccact caccacctct gctagttcca gacacctccc      900

aagcacgcag caatgcagct caaaacgctt agcctagcca cacccccacg ggaaacagca      960

gtgattaacc tttagcaata aacgaaagtt taactaagct atactaaccc cagggttggt     1020

caatttcgtg ccagccacac cctcgagcta gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aagcatatga ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aa                                              1162


<210>  50
<211>  1162
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine IL-15 sushi

<400>  50
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugggcgc       60

cauggccccu agaacauugc uccugcugcu ggccgcugcc cuggccccua cacagacaag      120

agcuggaccu ggauccacca cguguccacc ucccguaucu auugagcaug cugacauccg      180

ggucaagaau uacaguguga acuccaggga gagguauguc uguaacucug gcuuuaagcg      240

gaaagcugga acauccaccc ugauugagug ugugaucaac aagaacacaa auguugccca      300

cuggacaacu cccagccuca agugcaucag agaccccucc cuagcuggag ggagcggagg      360

cucuggcgga agcggcgggu cuggaggcuc cgggggaagc ggcggaaauu ggaucgacgu      420

gcgcuacgac cuggaaaaga ucgagagccu gauccagagc auccacaucg acaccacccu      480

guacaccgac agcgacuucc accccagcug caaagugacc gcuaugaacu gcuuccugcu      540

ggaacugcaa gugauccugc acgaguacag caacaugacc cugaacgaga cagugcggaa      600

cgugcuguac cuggccaaca gcacccugag cagcaacaag aacguggccg agagcggcug      660

caaagagugc gaggaacugg aagaaaagac cuucaccgag uuucugcaga gcuucaucag      720

gaucgugcag auguucauca acaccucuug augagucgac guccugguac ugcaugcacg      780

caaugcuagc ugccccuuuc ccguccuggg uaccccgagu cucccccgac cucggguccc      840

agguaugcuc ccaccuccac cugccccacu caccaccucu gcuaguucca gacaccuccc      900

aagcacgcag caaugcagcu caaaacgcuu agccuagcca cacccccacg ggaaacagca      960

gugauuaacc uuuagcaaua aacgaaaguu uaacuaagcu auacuaaccc caggguuggu     1020

caauuucgug ccagccacac ccucgagcua gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aagcauauga cuaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aa                                              1162


<210>  51
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine IL-15 sushi

<400>  51

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Thr Thr Cys Pro 
            20                  25                  30          


Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn Tyr Ser 
        35                  40                  45              


Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys Arg Lys 
    50                  55                  60                  


Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn Thr Asn 
65                  70                  75                  80  


Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ser 
                85                  90                  95      


Leu Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Ser Gly Gly Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu 
        115                 120                 125             


Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr 
    130                 135                 140                 


Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met Asn Cys 
145                 150                 155                 160 


Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr 
                165                 170                 175     


Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu 
            180                 185                 190         


Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu 
        195                 200                 205             


Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile 
    210                 215                 220                 


Val Gln Met Phe Ile Asn Thr Ser 
225                 230         


<210>  52
<211>  1255
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine IL-15 sushi (5'UTR-CDS-3'UTR)

<400>  52
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatcca ccacgtgtcc      240

acctcccgta tctattgagc atgctgacat ccgggtcaag aattacagtg tgaactccag      300

ggagaggtat gtctgtaact ctggctttaa gcggaaagct ggaacatcca ccctgattga      360

gtgtgtgatc aacaagaaca caaatgttgc ccactggaca actcccagcc tcaagtgcat      420

cagagacccc tccctagctg gagggagcgg aggctctggc ggaagcggcg ggtctggagg      480

ctccggggga agcggcggaa attggatcga cgtgcgctac gacctggaaa agatcgagag      540

cctgatccag agcatccaca tcgacaccac cctgtacacc gacagcgact tccaccccag      600

ctgcaaagtg accgctatga actgcttcct gctggaactg caagtgatcc tgcacgagta      660

cagcaacatg accctgaacg agacagtgcg gaacgtgctg tacctggcca acagcaccct      720

gagcagcaac aagaacgtgg ccgagagcgg ctgcaaagag tgcgaggaac tggaagaaaa      780

gaccttcacc gagtttctgc agagcttcat caggatcgtg cagatgttca tcaacacctc      840

ttgatgagtc gacgtcctgg tactgcatgc acgcaatgct agctgcccct ttcccgtcct      900

gggtaccccg agtctccccc gacctcgggt cccaggtatg ctcccacctc cacctgcccc      960

actcaccacc tctgctagtt ccagacacct cccaagcacg cagcaatgca gctcaaaacg     1020

cttagcctag ccacaccccc acgggaaaca gcagtgatta acctttagca ataaacgaaa     1080

gtttaactaa gctatactaa ccccagggtt ggtcaatttc gtgccagcca caccctcgag     1140

ctagcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagcata tgactaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1255


<210>  53
<211>  1255
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine IL-15 sushi

<400>  53
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggaucca ccacgugucc      240

accucccgua ucuauugagc augcugacau ccgggucaag aauuacagug ugaacuccag      300

ggagagguau gucuguaacu cuggcuuuaa gcggaaagcu ggaacaucca cccugauuga      360

gugugugauc aacaagaaca caaauguugc ccacuggaca acucccagcc ucaagugcau      420

cagagacccc ucccuagcug gagggagcgg aggcucuggc ggaagcggcg ggucuggagg      480

cuccggggga agcggcggaa auuggaucga cgugcgcuac gaccuggaaa agaucgagag      540

ccugauccag agcauccaca ucgacaccac ccuguacacc gacagcgacu uccaccccag      600

cugcaaagug accgcuauga acugcuuccu gcuggaacug caagugaucc ugcacgagua      660

cagcaacaug acccugaacg agacagugcg gaacgugcug uaccuggcca acagcacccu      720

gagcagcaac aagaacgugg ccgagagcgg cugcaaagag ugcgaggaac uggaagaaaa      780

gaccuucacc gaguuucugc agagcuucau caggaucgug cagauguuca ucaacaccuc      840

uugaugaguc gacguccugg uacugcaugc acgcaaugcu agcugccccu uucccguccu      900

ggguaccccg agucuccccc gaccucgggu cccagguaug cucccaccuc caccugcccc      960

acucaccacc ucugcuaguu ccagacaccu cccaagcacg cagcaaugca gcucaaaacg     1020

cuuagccuag ccacaccccc acgggaaaca gcagugauua accuuuagca auaaacgaaa     1080

guuuaacuaa gcuauacuaa ccccaggguu ggucaauuuc gugccagcca cacccucgag     1140

cuagcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagcaua ugacuaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          1255


<210>  54
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine GM-CSF

<400>  54

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  55
<211>  908
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine GM-CSF (5'UTR-CDS-3'UTR)

<400>  55
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgtggct       60

gcagaacctg ctgttcctgg gcatcgtggt gtacagcctg agcgccccca ccaggagccc      120

catcaccgtg accaggccct ggaagcacgt ggaggccatc aaggaggccc tgaacctgct      180

ggacgacatg cccgtgaccc tgaacgagga ggtggaggtg gtgagcaacg agttcagctt      240

caagaagctg acctgcgtgc agaccaggct gaagatcttc gagcagggcc tgaggggcaa      300

cttcaccaag ctgaagggcg ccctgaacat gaccgccagc tactaccaga cctactgccc      360

ccccaccccc gagaccgact gcgagaccca ggtgaccacc tacgccgact tcatcgacag      420

cctgaagacc ttcctgaccg acatcccctt cgagtgcaag aagcccggcc agaagtgatg      480

actcgagctg gtactgcatg cacgcaatgc tagctgcccc tttcccgtcc tgggtacccc      540

gagtctcccc cgacctcggg tcccaggtat gctcccacct ccacctgccc cactcaccac      600

ctctgctagt tccagacacc tcccaagcac gcagcaatgc agctcaaaac gcttagccta      660

gccacacccc cacgggaaac agcagtgatt aacctttagc aataaacgaa agtttaacta      720

agctatacta accccagggt tggtcaattt cgtgccagcc acaccgagac ctggtccaga      780

gtcgctagcc gcgtcgctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagc atatgactaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaa                                                               908


<210>  56
<211>  908
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine GM-CSF

<400>  56
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccauguggcu       60

gcagaaccug cuguuccugg gcaucguggu guacagccug agcgccccca ccaggagccc      120

caucaccgug accaggcccu ggaagcacgu ggaggccauc aaggaggccc ugaaccugcu      180

ggacgacaug cccgugaccc ugaacgagga gguggaggug gugagcaacg aguucagcuu      240

caagaagcug accugcgugc agaccaggcu gaagaucuuc gagcagggcc ugaggggcaa      300

cuucaccaag cugaagggcg cccugaacau gaccgccagc uacuaccaga ccuacugccc      360

ccccaccccc gagaccgacu gcgagaccca ggugaccacc uacgccgacu ucaucgacag      420

ccugaagacc uuccugaccg acauccccuu cgagugcaag aagcccggcc agaagugaug      480

acucgagcug guacugcaug cacgcaaugc uagcugcccc uuucccgucc uggguacccc      540

gagucucccc cgaccucggg ucccagguau gcucccaccu ccaccugccc cacucaccac      600

cucugcuagu uccagacacc ucccaagcac gcagcaaugc agcucaaaac gcuuagccua      660

gccacacccc cacgggaaac agcagugauu aaccuuuagc aauaaacgaa aguuuaacua      720

agcuauacua accccagggu uggucaauuu cgugccagcc acaccgagac cugguccaga      780

gucgcuagcc gcgucgcuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagc auaugacuaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaaaaaaa                                                               908


<210>  57
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine GM-CSF

<400>  57

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  58
<211>  1001
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine GM-CSF (5'UTR-CDS-3'UTR)

<400>  58
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatgtg gctgcagaac ctgctgttcc tgggcatcgt      180

ggtgtacagc ctgagcgccc ccaccaggag ccccatcacc gtgaccaggc cctggaagca      240

cgtggaggcc atcaaggagg ccctgaacct gctggacgac atgcccgtga ccctgaacga      300

ggaggtggag gtggtgagca acgagttcag cttcaagaag ctgacctgcg tgcagaccag      360

gctgaagatc ttcgagcagg gcctgagggg caacttcacc aagctgaagg gcgccctgaa      420

catgaccgcc agctactacc agacctactg cccccccacc cccgagaccg actgcgagac      480

ccaggtgacc acctacgccg acttcatcga cagcctgaag accttcctga ccgacatccc      540

cttcgagtgc aagaagcccg gccagaagtg atgactcgag ctggtactgc atgcacgcaa      600

tgctagctgc ccctttcccg tcctgggtac cccgagtctc ccccgacctc gggtcccagg      660

tatgctccca cctccacctg ccccactcac cacctctgct agttccagac acctcccaag      720

cacgcagcaa tgcagctcaa aacgcttagc ctagccacac ccccacggga aacagcagtg      780

attaaccttt agcaataaac gaaagtttaa ctaagctata ctaaccccag ggttggtcaa      840

tttcgtgcca gccacaccga gacctggtcc agagtcgcta gccgcgtcgc taaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa agcatatgac taaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         1001


<210>  59
<211>  1001
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine GM-CSF

<400>  59
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccaugug gcugcagaac cugcuguucc ugggcaucgu      180

gguguacagc cugagcgccc ccaccaggag ccccaucacc gugaccaggc ccuggaagca      240

cguggaggcc aucaaggagg cccugaaccu gcuggacgac augcccguga cccugaacga      300

ggagguggag guggugagca acgaguucag cuucaagaag cugaccugcg ugcagaccag      360

gcugaagauc uucgagcagg gccugagggg caacuucacc aagcugaagg gcgcccugaa      420

caugaccgcc agcuacuacc agaccuacug cccccccacc cccgagaccg acugcgagac      480

ccaggugacc accuacgccg acuucaucga cagccugaag accuuccuga ccgacauccc      540

cuucgagugc aagaagcccg gccagaagug augacucgag cugguacugc augcacgcaa      600

ugcuagcugc cccuuucccg uccuggguac cccgagucuc ccccgaccuc gggucccagg      660

uaugcuccca ccuccaccug ccccacucac caccucugcu aguuccagac accucccaag      720

cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac ccccacggga aacagcagug      780

auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua cuaaccccag gguuggucaa      840

uuucgugcca gccacaccga gaccuggucc agagucgcua gccgcgucgc uaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa agcauaugac uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         1001


<210>  60
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA FLT3L (human FLT3L in combination with a mouse optimized 
       secretion sequence)

<400>  60

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Thr Gln Asp Cys 
            20                  25                  30          


Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 
        35                  40                  45              


Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 
    50                  55                  60                  


Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 
65                  70                  75                  80  


Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 
                85                  90                  95      


Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 
            100                 105                 110         


Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 
        115                 120                 125             


Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 
    130                 135                 140                 


Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 
145                 150                 155                 160 


Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu 
                165                 170                 175     


Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro 
            180                 185         


<210>  61
<211>  1027
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA FLT3L (5'UTR-CDS-3'UTR)

<400>  61
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgggcgc       60

catggcccct agaacattgc tcctgctgct ggccgctgcc ctggccccta cacagacaag      120

agctggacct ggatccaccc aggactgcag cttccagcac tcccctatct cctccgactt      180

cgccgtgaag atccgggagc tgtccgatta cctgctgcag gactaccctg tgaccgtggc      240

cagcaacctg caggacgaag aactgtgtgg cggcctgtgg cggctggtgc tggcccagcg      300

gtggatggaa cggctgaaaa ccgtggccgg ctccaagatg cagggcctgc tcgagcgggt      360

gaacaccgag atccacttcg tgaccaagtg cgccttccag cctcctcctt cctgcctgcg      420

gttcgtgcag accaacatct cccggctgct gcaggaaacc tccgagcagc tggtcgccct      480

gaagccttgg atcacccggc agaacttctc ccggtgtctg gaactccagt gtcagcccga      540

ctcctccacc ctgcctcctc cctggtcccc caggcctctg gaagccaccg cccctaccgc      600

cccacagcct ccttgatagg tcgacgtcct ggtactgcat gcacgcaatg ctagctgccc      660

ctttcccgtc ctgggtaccc cgagtctccc ccgacctcgg gtcccaggta tgctcccacc      720

tccacctgcc ccactcacca cctctgctag ttccagacac ctcccaagca cgcagcaatg      780

cagctcaaaa cgcttagcct agccacaccc ccacgggaaa cagcagtgat taacctttag      840

caataaacga aagtttaact aagctatact aaccccaggg ttggtcaatt tcgtgccagc      900

cacaccctcg agctagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagca tatgactaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaa                                                               1027


<210>  62
<211>  1027
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA FLT3L

<400>  62
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugggcgc       60

cauggccccu agaacauugc uccugcugcu ggccgcugcc cuggccccua cacagacaag      120

agcuggaccu ggauccaccc aggacugcag cuuccagcac uccccuaucu ccuccgacuu      180

cgccgugaag auccgggagc uguccgauua ccugcugcag gacuacccug ugaccguggc      240

cagcaaccug caggacgaag aacugugugg cggccugugg cggcuggugc uggcccagcg      300

guggauggaa cggcugaaaa ccguggccgg cuccaagaug cagggccugc ucgagcgggu      360

gaacaccgag auccacuucg ugaccaagug cgccuuccag ccuccuccuu ccugccugcg      420

guucgugcag accaacaucu cccggcugcu gcaggaaacc uccgagcagc uggucgcccu      480

gaagccuugg aucacccggc agaacuucuc ccggugucug gaacuccagu gucagcccga      540

cuccuccacc cugccuccuc ccuggucccc caggccucug gaagccaccg ccccuaccgc      600

cccacagccu ccuugauagg ucgacguccu gguacugcau gcacgcaaug cuagcugccc      660

cuuucccguc cuggguaccc cgagucuccc ccgaccucgg gucccaggua ugcucccacc      720

uccaccugcc ccacucacca ccucugcuag uuccagacac cucccaagca cgcagcaaug      780

cagcucaaaa cgcuuagccu agccacaccc ccacgggaaa cagcagugau uaaccuuuag      840

caauaaacga aaguuuaacu aagcuauacu aaccccaggg uuggucaauu ucgugccagc      900

cacacccucg agcuagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagca uaugacuaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaa                                                               1027


<210>  63
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB FLT3L (human FLT3L in combination with a mouse optimized 
       secretion sequence)

<400>  63

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser Thr Gln Asp Cys 
            20                  25                  30          


Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 
        35                  40                  45              


Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 
    50                  55                  60                  


Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 
65                  70                  75                  80  


Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 
                85                  90                  95      


Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 
            100                 105                 110         


Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 
        115                 120                 125             


Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 
    130                 135                 140                 


Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 
145                 150                 155                 160 


Gln Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu 
                165                 170                 175     


Glu Ala Thr Ala Pro Thr Ala Pro Gln Pro Pro 
            180                 185         


<210>  64
<211>  1120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB FLT3L (5'UTR-CDS-3'UTR)

<400>  64
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatcca cccaggactg      240

cagcttccag cactccccta tctcctccga cttcgccgtg aagatccggg agctgtccga      300

ttacctgctg caggactacc ctgtgaccgt ggccagcaac ctgcaggacg aagaactgtg      360

tggcggcctg tggcggctgg tgctggccca gcggtggatg gaacggctga aaaccgtggc      420

cggctccaag atgcagggcc tgctcgagcg ggtgaacacc gagatccact tcgtgaccaa      480

gtgcgccttc cagcctcctc cttcctgcct gcggttcgtg cagaccaaca tctcccggct      540

gctgcaggaa acctccgagc agctggtcgc cctgaagcct tggatcaccc ggcagaactt      600

ctcccggtgt ctggaactcc agtgtcagcc cgactcctcc accctgcctc ctccctggtc      660

ccccaggcct ctggaagcca ccgcccctac cgccccacag cctccttgat aggtcgacgt      720

cctggtactg catgcacgca atgctagctg cccctttccc gtcctgggta ccccgagtct      780

cccccgacct cgggtcccag gtatgctccc acctccacct gccccactca ccacctctgc      840

tagttccaga cacctcccaa gcacgcagca atgcagctca aaacgcttag cctagccaca      900

cccccacggg aaacagcagt gattaacctt tagcaataaa cgaaagttta actaagctat      960

actaacccca gggttggtca atttcgtgcc agccacaccc tcgagctagc aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa gcatatgact aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1120


<210>  65
<211>  1120
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine FLT3L

<400>  65
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggaucca cccaggacug      240

cagcuuccag cacuccccua ucuccuccga cuucgccgug aagauccggg agcuguccga      300

uuaccugcug caggacuacc cugugaccgu ggccagcaac cugcaggacg aagaacugug      360

uggcggccug uggcggcugg ugcuggccca gcgguggaug gaacggcuga aaaccguggc      420

cggcuccaag augcagggcc ugcucgagcg ggugaacacc gagauccacu ucgugaccaa      480

gugcgccuuc cagccuccuc cuuccugccu gcgguucgug cagaccaaca ucucccggcu      540

gcugcaggaa accuccgagc agcuggucgc ccugaagccu uggaucaccc ggcagaacuu      600

cucccggugu cuggaacucc agugucagcc cgacuccucc acccugccuc cucccugguc      660

ccccaggccu cuggaagcca ccgccccuac cgccccacag ccuccuugau aggucgacgu      720

ccugguacug caugcacgca augcuagcug ccccuuuccc guccugggua ccccgagucu      780

cccccgaccu cgggucccag guaugcuccc accuccaccu gccccacuca ccaccucugc      840

uaguuccaga caccucccaa gcacgcagca augcagcuca aaacgcuuag ccuagccaca      900

cccccacggg aaacagcagu gauuaaccuu uagcaauaaa cgaaaguuua acuaagcuau      960

acuaacccca ggguugguca auuucgugcc agccacaccc ucgagcuagc aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1120


<210>  66
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine 41BBL

<400>  66

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  67
<211>  1393
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine 41BBL (5'UTR-CDS-3'UTR)

<400>  67
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatggacca       60

gcacacactt gatgtggagg ataccgcgga tgccagacat ccagcaggta cttcgtgccc      120

ctcggatgcg gcgctcctca gagataccgg gctcctcgcg gacgctgcgc tcctctcaga      180

tactgtgcgc cccacaaatg ccgcgctccc cacggatgct gcctaccctg cggttaatgt      240

tcgggatcgc gaggccgcgt ggccgcctgc actgaacttc tgttcccgcc acccaaagct      300

ctatggccta gtcgctttgg ttttgctgct tctgatcgcc gcctgtgttc ctatcttcac      360

ccgcaccgag cctcggccag cgctcacaat caccacctcg cccaacctgg gtacccgaga      420

gaataatgca gaccaggtca cccctgtttc ccacattggc tgccccaaca ctacacaaca      480

gggctctcct gtgttcgcca agctactggc taaaaaccaa gcatcgttgt gcaatacaac      540

tctgaactgg cacagccaag atggagctgg gagctcatac ctatctcaag gtctgaggta      600

cgaagaagac aaaaaggagt tggtggtaga cagtcccggg ctctactacg tatttttgga      660

actgaagctc agtccaacat tcacaaacac aggccacaag gtgcagggct gggtctctct      720

tgttttgcaa gcaaagcctc aggtagatga ctttgacaac ttggccctga cagtggaact      780

gttcccttgc tccatggaga acaagttagt ggaccgttcc tggagtcaac tgttgctcct      840

gaaggctggc caccgcctca gtgtgggtct gagggcttat ctgcatggag cccaggatgc      900

atacagagac tgggagctgt cttatcccaa caccaccagc tttggactct ttcttgtgaa      960

acccgacaac ccatgggaat gatagggatc cgatctggta ctgcatgcac gcaatgctag     1020

ctgccccttt cccgtcctgg gtaccccgag tctcccccga cctcgggtcc caggtatgct     1080

cccacctcca cctgccccac tcaccacctc tgctagttcc agacacctcc caagcacgca     1140

gcaatgcagc tcaaaacgct tagcctagcc acacccccac gggaaacagc agtgattaac     1200

ctttagcaat aaacgaaagt ttaactaagc tatactaacc ccagggttgg tcaatttcgt     1260

gccagccaca ccctcgagct agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcatatg     1320

actaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaa                                                        1393


<210>  68
<211>  1393
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine 41BBL

<400>  68
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccauggacca       60

gcacacacuu gauguggagg auaccgcgga ugccagacau ccagcaggua cuucgugccc      120

cucggaugcg gcgcuccuca gagauaccgg gcuccucgcg gacgcugcgc uccucucaga      180

uacugugcgc cccacaaaug ccgcgcuccc cacggaugcu gccuacccug cgguuaaugu      240

ucgggaucgc gaggccgcgu ggccgccugc acugaacuuc uguucccgcc acccaaagcu      300

cuauggccua gucgcuuugg uuuugcugcu ucugaucgcc gccuguguuc cuaucuucac      360

ccgcaccgag ccucggccag cgcucacaau caccaccucg cccaaccugg guacccgaga      420

gaauaaugca gaccagguca ccccuguuuc ccacauuggc ugccccaaca cuacacaaca      480

gggcucuccu guguucgcca agcuacuggc uaaaaaccaa gcaucguugu gcaauacaac      540

ucugaacugg cacagccaag auggagcugg gagcucauac cuaucucaag gucugaggua      600

cgaagaagac aaaaaggagu uggugguaga cagucccggg cucuacuacg uauuuuugga      660

acugaagcuc aguccaacau ucacaaacac aggccacaag gugcagggcu gggucucucu      720

uguuuugcaa gcaaagccuc agguagauga cuuugacaac uuggcccuga caguggaacu      780

guucccuugc uccauggaga acaaguuagu ggaccguucc uggagucaac uguugcuccu      840

gaaggcuggc caccgccuca gugugggucu gagggcuuau cugcauggag cccaggaugc      900

auacagagac ugggagcugu cuuaucccaa caccaccagc uuuggacucu uucuugugaa      960

acccgacaac ccaugggaau gauagggauc cgaucuggua cugcaugcac gcaaugcuag     1020

cugccccuuu cccguccugg guaccccgag ucucccccga ccucgggucc cagguaugcu     1080

cccaccucca ccugccccac ucaccaccuc ugcuaguucc agacaccucc caagcacgca     1140

gcaaugcagc ucaaaacgcu uagccuagcc acacccccac gggaaacagc agugauuaac     1200

cuuuagcaau aaacgaaagu uuaacuaagc uauacuaacc ccaggguugg ucaauuucgu     1260

gccagccaca cccucgagcu agcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcauaug     1320

acuaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaa                                                        1393


<210>  69
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine 41BBL

<400>  69

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  70
<211>  1486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine 41BBL (5'UTR-CDS-3'UTR)

<400>  70
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatgga ccagcacaca cttgatgtgg aggataccgc      180

ggatgccaga catccagcag gtacttcgtg cccctcggat gcggcgctcc tcagagatac      240

cgggctcctc gcggacgctg cgctcctctc agatactgtg cgccccacaa atgccgcgct      300

ccccacggat gctgcctacc ctgcggttaa tgttcgggat cgcgaggccg cgtggccgcc      360

tgcactgaac ttctgttccc gccacccaaa gctctatggc ctagtcgctt tggttttgct      420

gcttctgatc gccgcctgtg ttcctatctt cacccgcacc gagcctcggc cagcgctcac      480

aatcaccacc tcgcccaacc tgggtacccg agagaataat gcagaccagg tcacccctgt      540

ttcccacatt ggctgcccca acactacaca acagggctct cctgtgttcg ccaagctact      600

ggctaaaaac caagcatcgt tgtgcaatac aactctgaac tggcacagcc aagatggagc      660

tgggagctca tacctatctc aaggtctgag gtacgaagaa gacaaaaagg agttggtggt      720

agacagtccc gggctctact acgtattttt ggaactgaag ctcagtccaa cattcacaaa      780

cacaggccac aaggtgcagg gctgggtctc tcttgttttg caagcaaagc ctcaggtaga      840

tgactttgac aacttggccc tgacagtgga actgttccct tgctccatgg agaacaagtt      900

agtggaccgt tcctggagtc aactgttgct cctgaaggct ggccaccgcc tcagtgtggg      960

tctgagggct tatctgcatg gagcccagga tgcatacaga gactgggagc tgtcttatcc     1020

caacaccacc agctttggac tctttcttgt gaaacccgac aacccatggg aatgataggg     1080

atccgatctg gtactgcatg cacgcaatgc tagctgcccc tttcccgtcc tgggtacccc     1140

gagtctcccc cgacctcggg tcccaggtat gctcccacct ccacctgccc cactcaccac     1200

ctctgctagt tccagacacc tcccaagcac gcagcaatgc agctcaaaac gcttagccta     1260

gccacacccc cacgggaaac agcagtgatt aacctttagc aataaacgaa agtttaacta     1320

agctatacta accccagggt tggtcaattt cgtgccagcc acaccctcga gctagcaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaagcat atgactaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    1486


<210>  71
<211>  1486
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine 41BBL

<400>  71
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccaugga ccagcacaca cuugaugugg aggauaccgc      180

ggaugccaga cauccagcag guacuucgug ccccucggau gcggcgcucc ucagagauac      240

cgggcuccuc gcggacgcug cgcuccucuc agauacugug cgccccacaa augccgcgcu      300

ccccacggau gcugccuacc cugcgguuaa uguucgggau cgcgaggccg cguggccgcc      360

ugcacugaac uucuguuccc gccacccaaa gcucuauggc cuagucgcuu ugguuuugcu      420

gcuucugauc gccgccugug uuccuaucuu cacccgcacc gagccucggc cagcgcucac      480

aaucaccacc ucgcccaacc uggguacccg agagaauaau gcagaccagg ucaccccugu      540

uucccacauu ggcugcccca acacuacaca acagggcucu ccuguguucg ccaagcuacu      600

ggcuaaaaac caagcaucgu ugugcaauac aacucugaac uggcacagcc aagauggagc      660

ugggagcuca uaccuaucuc aaggucugag guacgaagaa gacaaaaagg aguugguggu      720

agacaguccc gggcucuacu acguauuuuu ggaacugaag cucaguccaa cauucacaaa      780

cacaggccac aaggugcagg gcugggucuc ucuuguuuug caagcaaagc cucagguaga      840

ugacuuugac aacuuggccc ugacagugga acuguucccu ugcuccaugg agaacaaguu      900

aguggaccgu uccuggaguc aacuguugcu ccugaaggcu ggccaccgcc ucaguguggg      960

ucugagggcu uaucugcaug gagcccagga ugcauacaga gacugggagc ugucuuaucc     1020

caacaccacc agcuuuggac ucuuucuugu gaaacccgac aacccauggg aaugauaggg     1080

auccgaucug guacugcaug cacgcaaugc uagcugcccc uuucccgucc uggguacccc     1140

gagucucccc cgaccucggg ucccagguau gcucccaccu ccaccugccc cacucaccac     1200

cucugcuagu uccagacacc ucccaagcac gcagcaaugc agcucaaaac gcuuagccua     1260

gccacacccc cacgggaaac agcagugauu aaccuuuagc aauaaacgaa aguuuaacua     1320

agcuauacua accccagggu uggucaauuu cgugccagcc acacccucga gcuagcaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaagcau augacuaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    1486


<210>  72
<211>  935
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModA murine CD27L-CD40L

<400>  72

Met Arg Val Thr Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser Gly Ser His Pro Glu Pro 
            20                  25                  30          


His Thr Ala Glu Leu Gln Leu Asn Leu Thr Val Pro Arg Lys Asp Pro 
        35                  40                  45              


Thr Leu Arg Trp Gly Ala Gly Pro Ala Leu Gly Arg Ser Phe Thr His 
    50                  55                  60                  


Gly Pro Glu Leu Glu Glu Gly His Leu Arg Ile His Gln Asp Gly Leu 
65                  70                  75                  80  


Tyr Arg Leu His Ile Gln Val Thr Leu Ala Asn Cys Ser Ser Pro Gly 
                85                  90                  95      


Ser Thr Leu Gln His Arg Ala Thr Leu Ala Val Gly Ile Cys Ser Pro 
            100                 105                 110         


Ala Ala His Gly Ile Ser Leu Leu Arg Gly Arg Phe Gly Gln Asp Cys 
        115                 120                 125             


Thr Val Ala Leu Gln Arg Leu Thr Tyr Leu Val His Gly Asp Val Leu 
    130                 135                 140                 


Cys Thr Asn Leu Thr Leu Pro Leu Leu Pro Ser Arg Asn Ala Asp Glu 
145                 150                 155                 160 


Thr Phe Phe Gly Val Gln Trp Ile Cys Pro Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly His Pro Glu Pro His Thr Ala Glu Leu Gln Leu Asn Leu Thr Val 
            180                 185                 190         


Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly Pro Ala Leu Gly 
        195                 200                 205             


Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly His Leu Arg Ile 
    210                 215                 220                 


His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val Thr Leu Ala Asn 
225                 230                 235                 240 


Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala Thr Leu Ala Val 
                245                 250                 255     


Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu Leu Arg Gly Arg 
            260                 265                 270         


Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu Thr Tyr Leu Val 
        275                 280                 285             


His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro Leu Leu Pro Ser 
    290                 295                 300                 


Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp Ile Cys Pro Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly His Pro Glu Pro His Thr Ala Glu Leu Gln 
                325                 330                 335     


Leu Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala 
            340                 345                 350         


Gly Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu 
        355                 360                 365             


Gly His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln 
    370                 375                 380                 


Val Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg 
385                 390                 395                 400 


Ala Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser 
                405                 410                 415     


Leu Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg 
            420                 425                 430         


Leu Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu 
        435                 440                 445             


Pro Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln 
    450                 455                 460                 


Trp Ile Cys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser 
                485                 490                 495     


Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly 
            500                 505                 510         


Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln 
        515                 520                 525             


Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr 
    530                 535                 540                 


Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly 
545                 550                 555                 560 


Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala 
                565                 570                 575     


Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His 
            580                 585                 590         


Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn 
        595                 600                 605             


Val Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe 
    610                 615                 620                 


Gly Leu Leu Lys Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Glu Asp 
625                 630                 635                 640 


Pro Gln Ile Ala Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala 
                645                 650                 655     


Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn 
            660                 665                 670         


Leu Val Met Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly 
        675                 680                 685             


Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro 
    690                 695                 700                 


Ser Ser Gln Arg Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser 
705                 710                 715                 720 


Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser 
                725                 730                 735     


Gln Leu Cys Glu Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu 
            740                 745                 750         


Gln Ala Gly Ala Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val 
        755                 760                 765             


Ile His Arg Val Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly 
    770                 775                 780                 


Gly Ser Gly Gly Gly Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val 
785                 790                 795                 800 


Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys 
                805                 810                 815     


Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly 
            820                 825                 830         


Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln 
        835                 840                 845             


Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile 
    850                 855                 860                 


Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu 
865                 870                 875                 880 


Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser 
                885                 890                 895     


Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe 
            900                 905                 910         


Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser 
        915                 920                 925             


Ser Phe Gly Leu Leu Lys Leu 
    930                 935 


<210>  73
<211>  3281
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModA murine CD27L-CD40L (5'UTR-CDS-3'UTR)

<400>  73
gggcgaacta gtattcttct ggtccccaca gactcagaga gaacccgcca ccatgagagt       60

gaccgccccc agaaccctga tcctgctgct gtctggcgcc ctggccctga cagagacatg      120

ggccggaagc ggatcccacc ccgagcccca caccgccgaa ctgcagctga acctgaccgt      180

gcccagaaag gaccccaccc tgagatgggg agctggccct gctctgggca gatcctttac      240

acacggcccc gagctggaag aaggccacct gagaatccac caggacggcc tgtacagact      300

gcacatccaa gtgaccctgg ccaactgcag cagccctggc tctaccctgc agcacagagc      360

cacactggcc gtgggcatct gtagccctgc tgctcacgga atcagcctgc tgagaggcag      420

attcggccag gactgtaccg tggccctgca gaggctgacc tatctggtgc atggcgacgt      480

gctgtgcacc aacctgacac tgcctctgct gcccagcaga aacgccgacg aaacattctt      540

tggagtgcag tggatttgtc ctggcggagg gtccggggga ggacacccag aacctcatac      600

agctgaactg cagctgaacc tgaccgtgcc cagaaaggac cccaccctga gatggggagc      660

tggccctgct ctgggcagat cctttacaca cggccccgag ctggaagaag gccacctgag      720

aatccaccag gacggcctgt acagactgca catccaagtg accctggcca actgcagcag      780

ccctggctct accctgcagc acagagccac actggccgtg ggcatctgta gccctgctgc      840

tcacggaatc agcctgctga gaggcagatt cggccaggac tgtaccgtgg ccctgcagag      900

gctgacctat ctggtgcatg gcgacgtgct gtgcaccaac ctgacactgc ctctgctgcc      960

cagcagaaac gccgacgaaa cattctttgg agtgcagtgg atttgtcctg ggggaggctc     1020

cggaggcgga caccctgaac ctcatacagc tgaactgcag ctgaacctga ccgtgcccag     1080

aaaggacccc accctgagat ggggagctgg ccctgctctg ggcagatcct ttacacacgg     1140

ccccgagctg gaagaaggcc acctgagaat ccaccaggac ggcctgtaca gactgcacat     1200

ccaagtgacc ctggccaact gcagcagccc tggctctacc ctgcagcaca gagccacact     1260

ggccgtgggc atctgtagcc ctgctgctca cggaatcagc ctgctgagag gcagattcgg     1320

ccaggactgt accgtggccc tgcagaggct gacctatctg gtgcatggcg acgtgctgtg     1380

caccaacctg acactgcctc tgctgcccag cagaaacgcc gacgagacct tcttcggcgt     1440

ccagtggatc tgccccggag gcggtggtag tggaggtggc gggtccggtg gaggtggaag     1500

cggcgacgag gacccccaga tcgccgccca cgtggtgtct gaggccaaca gcaacgccgc     1560

ctctgtgctg cagtgggcca agaaaggcta ctacaccatg aagtccaacc tcgtgatgct     1620

ggaaaacggc aagcagctga ccgtgaagcg cgagggcctg tactatgtgt acacccaagt     1680

gacattctgc agcaaccgcg agcccagcag ccagaggcct tttatcgtgg gcctgtggct     1740

gaagcctagc agcggcagcg agagaatcct gctgaaggcc gccaacaccc acagcagctc     1800

tcagctgtgc gagcagcagt ctgtgcacct gggaggcgtg ttcgagctgc aagctggcgc     1860

ttccgtgttc gtgaacgtga ccgaggccag ccaagtgatc cacagagtgg gcttcagcag     1920

ctttggactg ctcaaactgg gcggagggtc cggcggaggc ggagatgaag atcctcagat     1980

tgctgcccac gtggtgtctg aggccaacag caacgccgcc tctgtgctgc agtgggccaa     2040

gaaaggctac tacaccatga agtccaacct cgtgatgctg gaaaacggca agcagctgac     2100

cgtgaagcgc gagggcctgt actatgtgta cacccaagtg acattctgca gcaaccgcga     2160

gcccagcagc cagaggcctt ttatcgtggg cctgtggctg aagcctagca gcggcagcga     2220

gagaatcctg ctgaaggccg ccaacaccca cagcagctct cagctgtgcg agcagcagtc     2280

tgtgcacctg ggaggcgtgt tcgagctgca agctggcgct tccgtgttcg tgaacgtgac     2340

cgaggccagc caagtgatcc acagagtggg cttcagcagc tttggactgc tcaaactggg     2400

aggcggctcc ggaggcggag gagatgaaga tcctcagatt gctgcccacg tggtgtctga     2460

ggccaacagc aacgccgcct ctgtgctgca gtgggccaag aaaggctact acaccatgaa     2520

gtccaacctc gtgatgctgg aaaacggcaa gcagctgacc gtgaagcgcg agggcctgta     2580

ctatgtgtac acccaagtga cattctgcag caaccgcgag cccagcagcc agaggccttt     2640

tatcgtgggc ctgtggctga agcctagcag cggcagcgag agaatcctgc tgaaggccgc     2700

caacacccac agcagctctc agctgtgcga gcagcagtct gtgcacctgg gaggcgtgtt     2760

cgagctgcaa gctggcgctt ccgtgttcgt gaacgtgacc gaggccagcc aagtgatcca     2820

cagagtgggc ttctcctcct tcggcctcct gaagctgtga ctcgagagct cgctttcttg     2880

ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat     2940

attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat tttcattgct     3000

gcgtcgagag ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag     3060

tccaactact aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata     3120

aaaaacattt attttcattg ctgcgtcgag acctggtcca gagtcgctag caaaaaaaaa     3180

aaaaaaaaaa aaaaaaaaaa agcatatgac taaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         3281


<210>  74
<211>  3281
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModA murine CD27L-CD40L

<400>  74
gggcgaacua guauucuucu gguccccaca gacucagaga gaacccgcca ccaugagagu       60

gaccgccccc agaacccuga uccugcugcu gucuggcgcc cuggcccuga cagagacaug      120

ggccggaagc ggaucccacc ccgagcccca caccgccgaa cugcagcuga accugaccgu      180

gcccagaaag gaccccaccc ugagaugggg agcuggcccu gcucugggca gauccuuuac      240

acacggcccc gagcuggaag aaggccaccu gagaauccac caggacggcc uguacagacu      300

gcacauccaa gugacccugg ccaacugcag cagcccuggc ucuacccugc agcacagagc      360

cacacuggcc gugggcaucu guagcccugc ugcucacgga aucagccugc ugagaggcag      420

auucggccag gacuguaccg uggcccugca gaggcugacc uaucuggugc auggcgacgu      480

gcugugcacc aaccugacac ugccucugcu gcccagcaga aacgccgacg aaacauucuu      540

uggagugcag uggauuuguc cuggcggagg guccggggga ggacacccag aaccucauac      600

agcugaacug cagcugaacc ugaccgugcc cagaaaggac cccacccuga gauggggagc      660

uggcccugcu cugggcagau ccuuuacaca cggccccgag cuggaagaag gccaccugag      720

aauccaccag gacggccugu acagacugca cauccaagug acccuggcca acugcagcag      780

cccuggcucu acccugcagc acagagccac acuggccgug ggcaucugua gcccugcugc      840

ucacggaauc agccugcuga gaggcagauu cggccaggac uguaccgugg cccugcagag      900

gcugaccuau cuggugcaug gcgacgugcu gugcaccaac cugacacugc cucugcugcc      960

cagcagaaac gccgacgaaa cauucuuugg agugcagugg auuuguccug ggggaggcuc     1020

cggaggcgga cacccugaac cucauacagc ugaacugcag cugaaccuga ccgugcccag     1080

aaaggacccc acccugagau ggggagcugg cccugcucug ggcagauccu uuacacacgg     1140

ccccgagcug gaagaaggcc accugagaau ccaccaggac ggccuguaca gacugcacau     1200

ccaagugacc cuggccaacu gcagcagccc uggcucuacc cugcagcaca gagccacacu     1260

ggccgugggc aucuguagcc cugcugcuca cggaaucagc cugcugagag gcagauucgg     1320

ccaggacugu accguggccc ugcagaggcu gaccuaucug gugcauggcg acgugcugug     1380

caccaaccug acacugccuc ugcugcccag cagaaacgcc gacgagaccu ucuucggcgu     1440

ccaguggauc ugccccggag gcggugguag uggagguggc ggguccggug gagguggaag     1500

cggcgacgag gacccccaga ucgccgccca cguggugucu gaggccaaca gcaacgccgc     1560

cucugugcug cagugggcca agaaaggcua cuacaccaug aaguccaacc ucgugaugcu     1620

ggaaaacggc aagcagcuga ccgugaagcg cgagggccug uacuaugugu acacccaagu     1680

gacauucugc agcaaccgcg agcccagcag ccagaggccu uuuaucgugg gccuguggcu     1740

gaagccuagc agcggcagcg agagaauccu gcugaaggcc gccaacaccc acagcagcuc     1800

ucagcugugc gagcagcagu cugugcaccu gggaggcgug uucgagcugc aagcuggcgc     1860

uuccguguuc gugaacguga ccgaggccag ccaagugauc cacagagugg gcuucagcag     1920

cuuuggacug cucaaacugg gcggaggguc cggcggaggc ggagaugaag auccucagau     1980

ugcugcccac guggugucug aggccaacag caacgccgcc ucugugcugc agugggccaa     2040

gaaaggcuac uacaccauga aguccaaccu cgugaugcug gaaaacggca agcagcugac     2100

cgugaagcgc gagggccugu acuaugugua cacccaagug acauucugca gcaaccgcga     2160

gcccagcagc cagaggccuu uuaucguggg ccuguggcug aagccuagca gcggcagcga     2220

gagaauccug cugaaggccg ccaacaccca cagcagcucu cagcugugcg agcagcaguc     2280

ugugcaccug ggaggcgugu ucgagcugca agcuggcgcu uccguguucg ugaacgugac     2340

cgaggccagc caagugaucc acagaguggg cuucagcagc uuuggacugc ucaaacuggg     2400

aggcggcucc ggaggcggag gagaugaaga uccucagauu gcugcccacg uggugucuga     2460

ggccaacagc aacgccgccu cugugcugca gugggccaag aaaggcuacu acaccaugaa     2520

guccaaccuc gugaugcugg aaaacggcaa gcagcugacc gugaagcgcg agggccugua     2580

cuauguguac acccaaguga cauucugcag caaccgcgag cccagcagcc agaggccuuu     2640

uaucgugggc cuguggcuga agccuagcag cggcagcgag agaauccugc ugaaggccgc     2700

caacacccac agcagcucuc agcugugcga gcagcagucu gugcaccugg gaggcguguu     2760

cgagcugcaa gcuggcgcuu ccguguucgu gaacgugacc gaggccagcc aagugaucca     2820

cagagugggc uucuccuccu ucggccuccu gaagcuguga cucgagagcu cgcuuucuug     2880

cuguccaauu ucuauuaaag guuccuuugu ucccuaaguc caacuacuaa acugggggau     2940

auuaugaagg gccuugagca ucuggauucu gccuaauaaa aaacauuuau uuucauugcu     3000

gcgucgagag cucgcuuucu ugcuguccaa uuucuauuaa agguuccuuu guucccuaag     3060

uccaacuacu aaacuggggg auauuaugaa gggccuugag caucuggauu cugccuaaua     3120

aaaaacauuu auuuucauug cugcgucgag accuggucca gagucgcuag caaaaaaaaa     3180

aaaaaaaaaa aaaaaaaaaa agcauaugac uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         3281


<210>  75
<211>  935
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ModB murine CD27L-CD40L

<400>  75

Met Gly Ala Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Leu Ala Pro Thr Gln Thr Arg Ala Gly Pro Gly Ser His Pro Glu Pro 
            20                  25                  30          


His Thr Ala Glu Leu Gln Leu Asn Leu Thr Val Pro Arg Lys Asp Pro 
        35                  40                  45              


Thr Leu Arg Trp Gly Ala Gly Pro Ala Leu Gly Arg Ser Phe Thr His 
    50                  55                  60                  


Gly Pro Glu Leu Glu Glu Gly His Leu Arg Ile His Gln Asp Gly Leu 
65                  70                  75                  80  


Tyr Arg Leu His Ile Gln Val Thr Leu Ala Asn Cys Ser Ser Pro Gly 
                85                  90                  95      


Ser Thr Leu Gln His Arg Ala Thr Leu Ala Val Gly Ile Cys Ser Pro 
            100                 105                 110         


Ala Ala His Gly Ile Ser Leu Leu Arg Gly Arg Phe Gly Gln Asp Cys 
        115                 120                 125             


Thr Val Ala Leu Gln Arg Leu Thr Tyr Leu Val His Gly Asp Val Leu 
    130                 135                 140                 


Cys Thr Asn Leu Thr Leu Pro Leu Leu Pro Ser Arg Asn Ala Asp Glu 
145                 150                 155                 160 


Thr Phe Phe Gly Val Gln Trp Ile Cys Pro Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly His Pro Glu Pro His Thr Ala Glu Leu Gln Leu Asn Leu Thr Val 
            180                 185                 190         


Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly Pro Ala Leu Gly 
        195                 200                 205             


Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly His Leu Arg Ile 
    210                 215                 220                 


His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val Thr Leu Ala Asn 
225                 230                 235                 240 


Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala Thr Leu Ala Val 
                245                 250                 255     


Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu Leu Arg Gly Arg 
            260                 265                 270         


Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu Thr Tyr Leu Val 
        275                 280                 285             


His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro Leu Leu Pro Ser 
    290                 295                 300                 


Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp Ile Cys Pro Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly His Pro Glu Pro His Thr Ala Glu Leu Gln 
                325                 330                 335     


Leu Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala 
            340                 345                 350         


Gly Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu 
        355                 360                 365             


Gly His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln 
    370                 375                 380                 


Val Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg 
385                 390                 395                 400 


Ala Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser 
                405                 410                 415     


Leu Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg 
            420                 425                 430         


Leu Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu 
        435                 440                 445             


Pro Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln 
    450                 455                 460                 


Trp Ile Cys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser 
                485                 490                 495     


Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly 
            500                 505                 510         


Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln 
        515                 520                 525             


Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr 
    530                 535                 540                 


Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly 
545                 550                 555                 560 


Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala 
                565                 570                 575     


Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His 
            580                 585                 590         


Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn 
        595                 600                 605             


Val Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe 
    610                 615                 620                 


Gly Leu Leu Lys Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Glu Asp 
625                 630                 635                 640 


Pro Gln Ile Ala Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala 
                645                 650                 655     


Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn 
            660                 665                 670         


Leu Val Met Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly 
        675                 680                 685             


Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro 
    690                 695                 700                 


Ser Ser Gln Arg Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser 
705                 710                 715                 720 


Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser 
                725                 730                 735     


Gln Leu Cys Glu Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu 
            740                 745                 750         


Gln Ala Gly Ala Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val 
        755                 760                 765             


Ile His Arg Val Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly 
    770                 775                 780                 


Gly Ser Gly Gly Gly Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val 
785                 790                 795                 800 


Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys 
                805                 810                 815     


Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly 
            820                 825                 830         


Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln 
        835                 840                 845             


Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile 
    850                 855                 860                 


Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu 
865                 870                 875                 880 


Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser 
                885                 890                 895     


Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe 
            900                 905                 910         


Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser 
        915                 920                 925             


Ser Phe Gly Leu Leu Lys Leu 
    930                 935 


<210>  76
<211>  3361
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ModB murine CD27L-CD40L (5'UTR-CDS-3'UTR)

<400>  76
ggaataaact agtctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat       60

tctacttcta ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa      120

ttttcaccat ttacgaacga tagccatggg cgccatggcc cctagaacat tgctcctgct      180

gctggccgct gccctggccc ctacacagac aagagctgga cctggatccc accccgagcc      240

ccacaccgcc gaactgcagc tgaacctgac cgtgcccaga aaggacccca ccctgagatg      300

gggagctggc cctgctctgg gcagatcctt tacacacggc cccgagctgg aagaaggcca      360

cctgagaatc caccaggacg gcctgtacag actgcacatc caagtgaccc tggccaactg      420

cagcagccct ggctctaccc tgcagcacag agccacactg gccgtgggca tctgtagccc      480

tgctgctcac ggaatcagcc tgctgagagg cagattcggc caggactgta ccgtggccct      540

gcagaggctg acctatctgg tgcatggcga cgtgctgtgc accaacctga cactgcctct      600

gctgcccagc agaaacgccg acgaaacatt ctttggagtg cagtggattt gtcctggcgg      660

agggtccggg ggaggacacc cagaacctca tacagctgaa ctgcagctga acctgaccgt      720

gcccagaaag gaccccaccc tgagatgggg agctggccct gctctgggca gatcctttac      780

acacggcccc gagctggaag aaggccacct gagaatccac caggacggcc tgtacagact      840

gcacatccaa gtgaccctgg ccaactgcag cagccctggc tctaccctgc agcacagagc      900

cacactggcc gtgggcatct gtagccctgc tgctcacgga atcagcctgc tgagaggcag      960

attcggccag gactgtaccg tggccctgca gaggctgacc tatctggtgc atggcgacgt     1020

gctgtgcacc aacctgacac tgcctctgct gcccagcaga aacgccgacg aaacattctt     1080

tggagtgcag tggatttgtc ctgggggagg ctccggaggc ggacaccctg aacctcatac     1140

agctgaactg cagctgaacc tgaccgtgcc cagaaaggac cccaccctga gatggggagc     1200

tggccctgct ctgggcagat cctttacaca cggccccgag ctggaagaag gccacctgag     1260

aatccaccag gacggcctgt acagactgca catccaagtg accctggcca actgcagcag     1320

ccctggctct accctgcagc acagagccac actggccgtg ggcatctgta gccctgctgc     1380

tcacggaatc agcctgctga gaggcagatt cggccaggac tgtaccgtgg ccctgcagag     1440

gctgacctat ctggtgcatg gcgacgtgct gtgcaccaac ctgacactgc ctctgctgcc     1500

cagcagaaac gccgacgaga ccttcttcgg cgtccagtgg atctgccccg gaggcggtgg     1560

tagtggaggt ggcgggtccg gtggaggtgg aagcggcgac gaggaccccc agatcgccgc     1620

ccacgtggtg tctgaggcca acagcaacgc cgcctctgtg ctgcagtggg ccaagaaagg     1680

ctactacacc atgaagtcca acctcgtgat gctggaaaac ggcaagcagc tgaccgtgaa     1740

gcgcgagggc ctgtactatg tgtacaccca agtgacattc tgcagcaacc gcgagcccag     1800

cagccagagg ccttttatcg tgggcctgtg gctgaagcct agcagcggca gcgagagaat     1860

cctgctgaag gccgccaaca cccacagcag ctctcagctg tgcgagcagc agtctgtgca     1920

cctgggaggc gtgttcgagc tgcaagctgg cgcttccgtg ttcgtgaacg tgaccgaggc     1980

cagccaagtg atccacagag tgggcttcag cagctttgga ctgctcaaac tgggcggagg     2040

gtccggcgga ggcggagatg aagatcctca gattgctgcc cacgtggtgt ctgaggccaa     2100

cagcaacgcc gcctctgtgc tgcagtgggc caagaaaggc tactacacca tgaagtccaa     2160

cctcgtgatg ctggaaaacg gcaagcagct gaccgtgaag cgcgagggcc tgtactatgt     2220

gtacacccaa gtgacattct gcagcaaccg cgagcccagc agccagaggc cttttatcgt     2280

gggcctgtgg ctgaagccta gcagcggcag cgagagaatc ctgctgaagg ccgccaacac     2340

ccacagcagc tctcagctgt gcgagcagca gtctgtgcac ctgggaggcg tgttcgagct     2400

gcaagctggc gcttccgtgt tcgtgaacgt gaccgaggcc agccaagtga tccacagagt     2460

gggcttcagc agctttggac tgctcaaact gggaggcggc tccggaggcg gaggagatga     2520

agatcctcag attgctgccc acgtggtgtc tgaggccaac agcaacgccg cctctgtgct     2580

gcagtgggcc aagaaaggct actacaccat gaagtccaac ctcgtgatgc tggaaaacgg     2640

caagcagctg accgtgaagc gcgagggcct gtactatgtg tacacccaag tgacattctg     2700

cagcaaccgc gagcccagca gccagaggcc ttttatcgtg ggcctgtggc tgaagcctag     2760

cagcggcagc gagagaatcc tgctgaaggc cgccaacacc cacagcagct ctcagctgtg     2820

cgagcagcag tctgtgcacc tgggaggcgt gttcgagctg caagctggcg cttccgtgtt     2880

cgtgaacgtg accgaggcca gccaagtgat ccacagagtg ggcttctcct ccttcggcct     2940

cctgaagctg tgactcgacg tcctggtact gcatgcacgc aatgctagct gcccctttcc     3000

cgtcctgggt accccgagtc tcccccgacc tcgggtccca ggtatgctcc cacctccacc     3060

tgccccactc accacctctg ctagttccag acacctccca agcacgcagc aatgcagctc     3120

aaaacgctta gcctagccac acccccacgg gaaacagcag tgattaacct ttagcaataa     3180

acgaaagttt aactaagcta tactaacccc agggttggtc aatttcgtgc cagccacacc     3240

ctcgagctag caaaaaaaaa aaaaaaaaaa aaaaaaaaaa agcatatgac taaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

a                                                                     3361


<210>  77
<211>  3361
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ModB murine CD27L-CD40L

<400>  77
ggaauaaacu agucucaaca caacauauac aaaacaaacg aaucucaagc aaucaagcau       60

ucuacuucua uugcagcaau uuaaaucauu ucuuuuaaag caaaagcaau uuucugaaaa      120

uuuucaccau uuacgaacga uagccauggg cgccauggcc ccuagaacau ugcuccugcu      180

gcuggccgcu gcccuggccc cuacacagac aagagcugga ccuggauccc accccgagcc      240

ccacaccgcc gaacugcagc ugaaccugac cgugcccaga aaggacccca cccugagaug      300

gggagcuggc ccugcucugg gcagauccuu uacacacggc cccgagcugg aagaaggcca      360

ccugagaauc caccaggacg gccuguacag acugcacauc caagugaccc uggccaacug      420

cagcagcccu ggcucuaccc ugcagcacag agccacacug gccgugggca ucuguagccc      480

ugcugcucac ggaaucagcc ugcugagagg cagauucggc caggacugua ccguggcccu      540

gcagaggcug accuaucugg ugcauggcga cgugcugugc accaaccuga cacugccucu      600

gcugcccagc agaaacgccg acgaaacauu cuuuggagug caguggauuu guccuggcgg      660

aggguccggg ggaggacacc cagaaccuca uacagcugaa cugcagcuga accugaccgu      720

gcccagaaag gaccccaccc ugagaugggg agcuggcccu gcucugggca gauccuuuac      780

acacggcccc gagcuggaag aaggccaccu gagaauccac caggacggcc uguacagacu      840

gcacauccaa gugacccugg ccaacugcag cagcccuggc ucuacccugc agcacagagc      900

cacacuggcc gugggcaucu guagcccugc ugcucacgga aucagccugc ugagaggcag      960

auucggccag gacuguaccg uggcccugca gaggcugacc uaucuggugc auggcgacgu     1020

gcugugcacc aaccugacac ugccucugcu gcccagcaga aacgccgacg aaacauucuu     1080

uggagugcag uggauuuguc cugggggagg cuccggaggc ggacacccug aaccucauac     1140

agcugaacug cagcugaacc ugaccgugcc cagaaaggac cccacccuga gauggggagc     1200

uggcccugcu cugggcagau ccuuuacaca cggccccgag cuggaagaag gccaccugag     1260

aauccaccag gacggccugu acagacugca cauccaagug acccuggcca acugcagcag     1320

cccuggcucu acccugcagc acagagccac acuggccgug ggcaucugua gcccugcugc     1380

ucacggaauc agccugcuga gaggcagauu cggccaggac uguaccgugg cccugcagag     1440

gcugaccuau cuggugcaug gcgacgugcu gugcaccaac cugacacugc cucugcugcc     1500

cagcagaaac gccgacgaga ccuucuucgg cguccagugg aucugccccg gaggcggugg     1560

uaguggaggu ggcggguccg guggaggugg aagcggcgac gaggaccccc agaucgccgc     1620

ccacguggug ucugaggcca acagcaacgc cgccucugug cugcaguggg ccaagaaagg     1680

cuacuacacc augaagucca accucgugau gcuggaaaac ggcaagcagc ugaccgugaa     1740

gcgcgagggc cuguacuaug uguacaccca agugacauuc ugcagcaacc gcgagcccag     1800

cagccagagg ccuuuuaucg ugggccugug gcugaagccu agcagcggca gcgagagaau     1860

ccugcugaag gccgccaaca cccacagcag cucucagcug ugcgagcagc agucugugca     1920

ccugggaggc guguucgagc ugcaagcugg cgcuuccgug uucgugaacg ugaccgaggc     1980

cagccaagug auccacagag ugggcuucag cagcuuugga cugcucaaac ugggcggagg     2040

guccggcgga ggcggagaug aagauccuca gauugcugcc cacguggugu cugaggccaa     2100

cagcaacgcc gccucugugc ugcagugggc caagaaaggc uacuacacca ugaaguccaa     2160

ccucgugaug cuggaaaacg gcaagcagcu gaccgugaag cgcgagggcc uguacuaugu     2220

guacacccaa gugacauucu gcagcaaccg cgagcccagc agccagaggc cuuuuaucgu     2280

gggccugugg cugaagccua gcagcggcag cgagagaauc cugcugaagg ccgccaacac     2340

ccacagcagc ucucagcugu gcgagcagca gucugugcac cugggaggcg uguucgagcu     2400

gcaagcuggc gcuuccgugu ucgugaacgu gaccgaggcc agccaaguga uccacagagu     2460

gggcuucagc agcuuuggac ugcucaaacu gggaggcggc uccggaggcg gaggagauga     2520

agauccucag auugcugccc acgugguguc ugaggccaac agcaacgccg ccucugugcu     2580

gcagugggcc aagaaaggcu acuacaccau gaaguccaac cucgugaugc uggaaaacgg     2640

caagcagcug accgugaagc gcgagggccu guacuaugug uacacccaag ugacauucug     2700

cagcaaccgc gagcccagca gccagaggcc uuuuaucgug ggccuguggc ugaagccuag     2760

cagcggcagc gagagaaucc ugcugaaggc cgccaacacc cacagcagcu cucagcugug     2820

cgagcagcag ucugugcacc ugggaggcgu guucgagcug caagcuggcg cuuccguguu     2880

cgugaacgug accgaggcca gccaagugau ccacagagug ggcuucuccu ccuucggccu     2940

ccugaagcug ugacucgacg uccugguacu gcaugcacgc aaugcuagcu gccccuuucc     3000

cguccugggu accccgaguc ucccccgacc ucggguccca gguaugcucc caccuccacc     3060

ugccccacuc accaccucug cuaguuccag acaccuccca agcacgcagc aaugcagcuc     3120

aaaacgcuua gccuagccac acccccacgg gaaacagcag ugauuaaccu uuagcaauaa     3180

acgaaaguuu aacuaagcua uacuaacccc aggguugguc aauuucgugc cagccacacc     3240

cucgagcuag caaaaaaaaa aaaaaaaaaa aaaaaaaaaa agcauaugac uaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

a                                                                     3361


<210>  78
<211>  110
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Poly-A

<400>  78
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  79
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-PD1 Mab heavy chain

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Gly Gly Arg Asp Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Trp Gly Asn Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  80
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-PD1 Mab light chain

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Ile Thr Ile Thr Cys Arg Ala Ser Leu Ser Ile Asn Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Asn Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Val Val Asp Phe Arg Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  81
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR1

<400>  81

Gly Phe Thr Phe Ser Asn Phe Gly 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR2

<400>  82

Ile Ser Gly Gly Gly Arg Asp Thr 
1               5               


<210>  83
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3

<400>  83

Val Lys Trp Gly Asn Ile Tyr Phe Asp Tyr 
1               5                   10  


<210>  84
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1

<400>  84

Leu Ser Ile Asn Thr Phe 
1               5       


<210>  85
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2

<400>  85

Ala Ala Ser 
1           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3

<400>  86

Gln Gln Ser Ser Asn Thr Pro Phe Thr 
1               5                   


<210>  87
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-PD1 Mab VH

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Gly Gly Arg Asp Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Trp Gly Asn Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  88
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-PD1 Mab VL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Ile Thr Ile Thr Cys Arg Ala Ser Leu Ser Ile Asn Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Asn Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Val Val Asp Phe Arg 
            100                 105         


