                         SEQUENCE LISTING

<110>  Auckland UniServices Limited
 
<120>  FGFR KINASE INHIBITORS AND PHARMACEUTICAL USES

<130>  AUS1002/PC

<150>  NZ729651
<151>  2017-03-03

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C584S FGFR1 kinase domain sequence

<400>  1
atgggccacc accaccacca ccactctgct gaaaacctgt acttccaggg tgctggtgtt       60

tctgaatacg aactgccgga agacccgcgt tgggaactgc cgcgtgaccg tctggttctg      120

ggtaaaccgc tgggtgaagg ttgcttcggt caggttgttc tggctgaagc tatcggtctg      180

gacaaagaca aaccgaaccg tgttaccaaa gttgctgtta aaatgctgaa atctgacgct      240

accgaaaaag acctgtctga cctgatctct gaaatggaaa tgatgaaaat gatcggtaaa      300

cacaaaaaca tcatcaacct gctgggtgct tgcacccagg acggtccgct gtacgttatc      360

gttgaatacg cttctaaagg taacctgcgt gaatacctgc aggctcgtcg tccgccgggt      420

ctggaatact cttacaaccc gtctcacaac ccggaagaac agctgtcttc taaagacctg      480

gtttcttgcg cttaccaggt tgctcgtggt atggaatacc tggcttctaa aaaatgcatc      540

caccgtgacc tggctgctcg taacgttctg gttaccgaag acaacgttat gaaaatcgct      600

gacttcggtc tggctcgtga catccaccac atcgactact acaaaaaaac caccaacggt      660

cgtctgccgg ttaaatggat ggctccggaa gctctgttcg accgtatcta cacccaccag      720

tctgacgttt ggtctttcgg tgttctgctg tgggaaatct tcaccctggg tggttctccg      780

tacccgggtg ttccggttga agaactgttc aaactgctga aagaaggtca ccgtatggac      840

aaaccgtcta actgcaccaa cgaactgtac atgatgatgc gtgactgctg gcacgctgtt      900

ccgtctcagc gtccgacctt caaacagctg gttgaagacc tggaccgtat cgttgctctg      960

acctctaacc aggaataa                                                    978


<210>  2
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C584S FGFR1 kinase domain sequence

<400>  2

Met Gly His His His His His His Ser Ala Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Gly Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu 
            20                  25                  30          


Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys 
        35                  40                  45              


Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys 
    50                  55                  60                  


Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala 
65                  70                  75                  80  


Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys 
                85                  90                  95      


Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr 
            100                 105                 110         


Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn 
        115                 120                 125             


Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Ser 
    130                 135                 140                 


Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu 
145                 150                 155                 160 


Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser 
                165                 170                 175     


Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr 
            180                 185                 190         


Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile 
        195                 200                 205             


His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val 
    210                 215                 220                 


Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln 
225                 230                 235                 240 


Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu 
                245                 250                 255     


Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu 
            260                 265                 270         


Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu 
        275                 280                 285             


Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg 
    290                 295                 300                 


Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu 
305                 310                 315                 320 


Thr Ser Asn Gln Glu 
                325 


<210>  3
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C584S FGFR1 kinase domain sequence

<400>  3

Gly Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu 
1               5                   10                  15      


Leu Pro Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys 
            20                  25                  30          


Phe Gly Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys 
        35                  40                  45              


Pro Asn Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala 
    50                  55                  60                  


Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys 
65                  70                  75                  80  


Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr 
                85                  90                  95      


Gln Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn 
            100                 105                 110         


Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Ser 
        115                 120                 125             


Tyr Asn Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu 
    130                 135                 140                 


Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser 
145                 150                 155                 160 


Lys Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr 
                165                 170                 175     


Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile 
            180                 185                 190         


His His Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val 
        195                 200                 205             


Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln 
    210                 215                 220                 


Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu 
                245                 250                 255     


Leu Lys Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu 
            260                 265                 270         


Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg 
        275                 280                 285             


Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu 
    290                 295                 300                 


Thr Ser Asn Gln Glu 
305                 


