                         SEQUENCE LISTING

<110>  Duke University
       Lynch, Michael D
       Melgar, Romel M
 
<120>  COMPLETE IN VIVO PROTEIN LIPIDATION THROUGH DYNAMIC METABOLIC 
       CONTROL OF ACYL-COA BIOSYNTHESIS

<130>  47381-11

<150>  62/463,811
<151>  2017-02-27

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  synthetic

<400>  1
tcctaatttt tgttgacact ctatc                                             25


<210>  2
<211>  25
<212>  DNA
<213>  synthetic

<400>  2
atcaaaggga aaactgtcca tatgc                                             25


<210>  3
<211>  74
<212>  DNA
<213>  synthetic

<400>  3
caaatgaata gccaactcaa aattcacacc tattaccttc ctctgcactt cctaattttt       60

gttgacactc tatc                                                         74


<210>  4
<211>  72
<212>  DNA
<213>  synthetic

<400>  4
aaataaagcg cacttttcta acaacctgtg ggggggatat cgccgctatc aaagggaaaa       60

ctgtccatat gc                                                           72


<210>  5
<211>  77
<212>  DNA
<213>  synthetic

<400>  5
agatataaaa aatacatatt caatcattaa aacgattgaa tggagaactt tttcctaatt       60

tttgttgaca ctctatc                                                      77


<210>  6
<211>  78
<212>  DNA
<213>  synthetic

<400>  6
gaaatggcta gttattcccc ggggcgattt tcacctcggg gaaattttag ttgatcaaag       60

ggaaaactgt ccatatgc                                                     78


<210>  7
<211>  22
<212>  DNA
<213>  synthetic

<400>  7
aacggataag acgggcataa at                                                22


<210>  8
<211>  23
<212>  DNA
<213>  synthetic

<400>  8
agattaaggg atgaaggaac gtc                                               23


<210>  9
<211>  21
<212>  DNA
<213>  synthetic

<400>  9
atttccgtgg acaactggtt a                                                 21


<210>  10
<211>  18
<212>  DNA
<213>  synthetic

<400>  10
ggacggcttc acacaaag                                                     18


<210>  11
<211>  22
<212>  DNA
<213>  synthetic

<400>  11
aactgaataa ttgcttgttt tt                                                22


<210>  12
<211>  22
<212>  DNA
<213>  synthetic

<400>  12
gctcaaacat atctaccaga ga                                                22


<210>  13
<211>  21
<212>  DNA
<213>  synthetic

<400>  13
atgactaacg tcagaaatag c                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  synthetic

<400>  14
cgggaggaat gatgtttaag                                                   20


<210>  15
<211>  23
<212>  DNA
<213>  synthetic

<400>  15
atgtttttac atccactaca acc                                               23


<210>  16
<211>  19
<212>  DNA
<213>  Escherichia coli

<400>  16
atccggatgg ctttaattt                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  synthetic

<400>  17
atgggtacgt ttgaccacc                                                    19


<210>  18
<211>  15
<212>  DNA
<213>  synthetic

<400>  18
gggaacgcag cagct                                                        15


<210>  19
<211>  39
<212>  DNA
<213>  synthetic

<400>  19
cattatatcc tccttaatag tattttataa aagttaaac                              39


<210>  20
<211>  21
<212>  DNA
<213>  synthetic

<400>  20
cagtccagtt acgctggagt c                                                 21


<210>  21
<211>  26
<212>  DNA
<213>  synthetic

<400>  21
ggtcaggtat gatttaaatg gtcagt                                            26


<210>  22
<211>  21
<212>  DNA
<213>  synthetic

<400>  22
gacgaattct ctagatatcg c                                                 21


<210>  23
<211>  18
<212>  DNA
<213>  synthetic

<400>  23
gcaggtatct tcgagcca                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  synthetic

<400>  24
tggctcgaag atacctgc                                                     18


<210>  25
<211>  18
<212>  DNA
<213>  synthetic

<400>  25
ggaaaccgtt gtggtctc                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  synthetic

<400>  26
aactcgttgc ctgctgag                                                     18


<210>  27
<211>  21
<212>  DNA
<213>  synthetic

<400>  27
gtgatggtga tggtgatgca t                                                 21


<210>  28
<211>  1243
<212>  DNA
<213>  synthetic

<400>  28
ccaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt       60

gtttgtcggt gaacgctctc tactagagtc acactggctc accttcgggt gggcctttct      120

gcgtttatac acagctaaca ccacgtcgtc cctatctgct gccctaggtc tatgagtggt      180

tgctggataa ctctttctga caccttacta tcttacaaat gtaacaaaaa agttattttt      240

ctgtaattcg agcatgtcat gttaccccgc gagcataaaa cgcgtatatt cagggagacc      300

acaacggttt ccctctacaa ataattttgt ttaactttga attcaaaaga tctggtacca      360

cctttaagaa ggagatatac atatgcgggg ttctcatcac catcatcacc atggtctggt      420

tccgcgtgga tcccttgttc ctgaattaaa tgaaaaagac gatgaccaag tacaaaaagc      480

tttggcatct agagaaaata ctcagttaat gaatagagat aatatagaga taacagtacg      540

tgattttaag accttggcac cacgaagatg gctaaatgac actatcattg agttttttat      600

gaaatacatt gaaaaatcta cccctaatac agtggcgttt aattcgtttt tctataccaa      660

tttatcagaa aggggttatc aaggcgtccg gaggtggatg aagagaaaga agacacaaat      720

tgataaactt gataaaatct ttacaccaat aaatttgaac caatcccact gggcgttggg      780

cataattgat ttaaaaaaga aaactatagg ttacgtagat tcattatcga atggtccaaa      840

tgctatgagt ttcgctatac tgactgactt gcaaaaatat gttatggagg aaagtaagca      900

tacaatagga gaagactttg atttgattca tttagattgt ccgcagcaac caaatggcta      960

cgactgtgga atatatgttt gtatgaatac tctctatgga agtgcagatg cgccattgga     1020

ttttgattat aaagatgcga ttaggatgag aagatttatt gcccatttga ttttaaccga     1080

cgctttaaaa taagaattcg aagcttgatc cggctgctaa caaagcccga aaggaagctg     1140

agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg     1200

tcttgagggg ttttttgctg aaaggaggaa ctatatccgg atc                       1243


<210>  29
<211>  749
<212>  DNA
<213>  synthetic

<400>  29
ccgcgacagc gtctgccgca ttattcaaag cgatattcag cattactgga atctgcgaat       60

tgtcgccagt tcgctatgtt taagccccag cctgctcaaa aagaaattaa aaaacgaaaa      120

taccagctat agccagattg tcacagagtg tcgtatgcgt tacgccgtac agatgttatt      180

gatggataac aaaaatatca ctcaggtggc gcaattatgt ggctatagca gcacgtcgta      240

ctttatctct gtttttaagg cgttttacgg cctgacaccg ttgaattatc tcgccaaaca      300

gcgacaaaaa gtgatgtggt gaagggcaaa gcggaaacgg ataagacggg cataaatgag      360

gaagaaatgg cgcgccctgc gaacgccaac taaaatttcc ccgaggtgaa aatcgccccg      420

gggaataact agccatttca atgtaacaat taacccttaa aataaaccca gaaggttatt      480

aactaaatca catagaaaac catcaattat agtatgtata aaataggcga cagcaaccca      540

attacaaatt aatggttcca gaatatcaca tcaaaaaaaa cgctgtataa tattataatt      600

aacatgtaga caacttgtaa taaacattat cagtcaattg ttttgtttat tccatctgtg      660

acgccgatta ttttctcaaa ataatgagat ggcgtgacac cataataatc tttaaatgca      720

catatgaaat atgaagtact gttatagcc                                        749


<210>  30
<211>  1223
<212>  DNA
<213>  synthetic

<400>  30
aactgaataa ttgcttgttt ttaaagaaaa agaaacagcg gctggtccgc tgtttctgca       60

ttcttacggt aaagataaaa ataaatagtg acgcgcttcg cgaatccatg tgggagttta      120

ttcttgacac agatatttat gatataataa ctgagtaagc ttaacataag gaggaaaaac      180

atatgttacg cagcagcaac gatgttacgc agcagggcag tcgccctaaa acaaagttag      240

gtggctcaag tatgggcatc attcgcacat gtaggctcgg ccctgaccaa gtcaaatcca      300

tgcgggctgc tcttgatctt ttcggtcgtg agttcggaga cgtagccacc tactcccaac      360

atcagccgga ctccgattac ctcgggaact tgctccgtag taagacattc atcgcgcttg      420

ctgccttcga ccaagaagcg gttgttggcg ctctcgcggc ttacgttctg cccaagtttg      480

agcagccgcg tagtgagatc tatatctatg atctcgcagt ctccggcgag caccggaggc      540

agggcattgc caccgcgctc atcaatctcc tcaagcatga ggccaacgcg cttggtgctt      600

atgtgatcta cgtgcaagca gattacggtg acgatcccgc agtggctctc tatacaaagt      660

tgggcatacg ggaagaagtg atgcactttg atatcgaccc aagtaccgcc acctatgccc      720

aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgt      780

ttgtcggtga acgctctcta ctagagtcac actggctcac cttcgggtgg gcctttctgc      840

gtttatacac agctaacacc acgtcgtccc tatctgctgc cctaggtcta tgagtggttg      900

ctggataacg tgcgtaattg tgctgatctc ttatatagct gctctcatta tctctctacc      960

ctgaagtgac tctctcacct gtaaaaataa tatctcacag gcttaatagt ttcttaatac     1020

aaagcctgta aaacgtcagg ataacttcta tattcaggga gaccacaacg gtttccctct     1080

acaaataatt ttgtttaact ttcgtaaaga ggagaaatac tagttgaaga aggtttggct     1140

taaccgttat cccgcggacg ttccgacgga gatcaaccct gaccgttatc aatctctggt     1200

agatatgttt gagcagtcgg tcg                                             1223


<210>  31
<211>  2018
<212>  DNA
<213>  synthetic

<400>  31
atgtttttac atccactaca accatatcat cacaagtggt cagacctcct acaagtaagg       60

ggcttttcgt tttactaaac tgaactttct gccggaatga cgctgatgcc acgaaagcta      120

tcggtaagtt tcggacgcca ttcggtctta gcgcgcagca cttcgctacc tccttccagc      180

tgcagcagat gttcgcaaac cagacctgct tcactgctac cgcccgatac cgtcgtcagg      240

ctctgtaaca cactatccat ggtacattca cgacgatatt cgatggtaaa gctactgata      300

tgatggcttt cgaagatgct atctggcacg gtttccagaa tccagtcaac gtatttgatg      360

ttgttgacat gttggttgat gtccaaatca ttccagcgcg gggtaagtcc cccttggata      420

taatcggcgg tgctatcgtt caatttctgc ggttttttaa tttcctcatc tttcacggcc      480

acgttgtcaa tgaaagccgg gccaatttca ccacgcactt cctccgggat tttagacaga      540

cgacgggtac gagtgttcat cataacgctc aggctcgtgc agcgggtcag aatctccccc      600

gttttgcaat cacgcactaa gaaatcgtga cgacgcccgt tattgccgga cgcccctacc      660

caacactcca cttcaactgt gtcgccccat gccggatagc gctccacggc aacatgggta      720

cgtttgacca cccaaataag atcacgctta gacatttcta acgtggtgcc aaaaccatct      780

cccaggatac caacagattt ggcatggttg agtgccgcct cctgtaagtg gttcatgact      840

gccacgatgc tagtactacg gtctgggccc acttcataag aacggatggc gaaggtgcgg      900

cggaacacca gaccatgcgg accgaaatgg tcgtccagga gctgtggcgg atttggtttg      960

ggtttccact ccagattcgt ccactgcttt tccgccgcac taaaaatggt agtgataacc     1020

gcgaataaca tgctccaatc cggcagtttt ttaagggatt cggtgtagct aaatttggta     1080

ccgttgatca ttttcaggct ggtctgtgca ttgccggcac gtaactgtaa gtcagagcta     1140

cgcggtttca tcccacgtcc atcgcgagcc agcataactg ctttcatcga acaaaaagcg     1200

ctcgccaggg atgtggttgc catctagtat ttctcctctt tacgaaagtt aaacaaaatt     1260

atttgtagag ggaaaccgtt gtggtctccc tgaatataga agttatcctg acgttttaca     1320

ggctttgtat taagaaacta ttaagcctgt gagatattat ttttacaggt gagagagtca     1380

cttcagggta gagagataat gagagcagct atataagaga tcagcacaat tacgcacgtt     1440

atccagcaac cactcataga cctagggcag cagataggga cgacgtggtg ttagctgtgt     1500

tgacaattaa tcatcggcat agtatatcgg catagtataa tacgactcac tataggaggg     1560

ccatcatggc caagttgacc agtgccgttc cggtgctcac cgcgcgcgac gtcgccggag     1620

cggtcgagtt ctggaccgac cggctcgggt tctcccggga cttcgtggag gacgacttcg     1680

ccggtgtggt ccgggacgac gtgaccctgt tcatcagcgc ggtccaggac caggtggtgc     1740

cggacaacac cctggcctgg gtgtgggtgc gcggcctgga cgagctgtac gccgagtggt     1800

cggaggtcgt gtccacgaac ttccgggacg cctccgggcc ggccatgacc gagatcggcg     1860

agcagccgtg ggggcgggag ttcgccctgc gcgacccggc cggcaactgc gtgcactttg     1920

tggcagagga gcaggactga ggataagata acggagccga aaggctccgt ttctttatcc     1980

gctaattatt taaaattaaa gccatccgga tggttttc                             2018


<210>  32
<211>  1598
<212>  DNA
<213>  synthetic

<400>  32
gagaccacaa cggtttccct ctacaaataa ttttgtttaa ctttaaagag gagaaatact       60

agatgcatca ccatcaccat cacatggcag atgaatcgga aaccgcggtt aaaccgccgg      120

cgccgcccct tccgcagatg atggaaggta acggcaatgg gcatgagcat tgcagcgact      180

gcgaaaacga ggaagataat tcgtataatc gtggtggact gtccccagcg aacgataccg      240

gtgcaaaaaa aaagaagaaa aagcagaaaa agaaaaaaga gaaaggcagc gaaaccgata      300

gcgctcaaga tcagccagtg aaaatgaact cgttgcctgc tgagcgtatc caagaaattc      360

agaaggcaat tgaactgttt agcgtgggtc aaggcccagc caaaacgatg gaggaagcga      420

gcaaacgttc gtatcagttc tgggatacgc aaccggtgcc gaagctcggt gaagtggtga      480

atacgcacgg gcctgttgag ccggataagg acaatattcg tcaggagcca tatacgctgc      540

ctcagggttt cacttgggac gccctggacc tgggtgaccg tggtgtgctg aaagaactgt      600

acaccctgct taatgagaat tatgtagaag atgacgacaa catgttccgt tttgactata      660

gcccggaatt cctgttatgg gcactccgtc cgccgggttg gctgccgcag tggcattgcg      720

gtgtccgcgt agtttcgagc cgtaaactcg taggtttcat cagtgcaatc ccggccaaca      780

ttcatatcta tgacaccgag aaaaaaatgg tagaaattaa cttcctgtgt gttcataaga      840

agttgcgtag caaacgcgta gcgcctgtcc tcattcgtga aatcacgcgc cgcgtacatt      900

tagaaggtat cttccaggca gtatatactg ctggcgtcgt gctcccaaaa ccggttggga      960

cttgccgcta ttggcaccgc tctctgaatc cgcgtaagct gattgaagtt aaatttagcc     1020

atttgtcacg caacatgacc atgcagcgca ccatgaaact ttaccgtctg ccggaaaccc     1080

cgaaaactgc tggtttgcgc ccaatggaga cgaaagatat tcctgtcgtc catcagctgc     1140

tgacgcgtta tttaaaacag tttcacttaa ctcctgtcat gagccaggaa gaggttgaac     1200

attggtttta tccgcaagaa aacatcatcg acaccttcgt agtggagaat gcgaatggcg     1260

aagtcacgga ctttttatcc ttctatactt tgccgagcac catcatgaac catccgaccc     1320

ataaaagcct gaaggccgcg tactcatttt ataatgtcca cacgcagacc ccgttattgg     1380

atctgatgtc tgatgcgttg gtcctggcca aaatgaaagg tttcgacgtt tttaatgcgc     1440

tggacctgat ggagaacaaa acctttctgg aaaaattgaa attcggaatt ggcgatggta     1500

atctgcaata ctatctgtat aattggaaat gcccgtcgat gggtgcggaa aaagttggtc     1560

tggtactgca gtagtaagac gaattctcta gatatcgc                             1598


<210>  33
<211>  2095
<212>  DNA
<213>  synthetic

<400>  33
cagtccagtt acgctggagt ctgcccaggc atcaaataaa acgaaaggct cagtcgaaag       60

actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctctactag agtcacactg      120

gctcaccttc gggtgggcct ttctgcgttt atacacagct aacaccacgt cgtccctatc      180

tgctgcccta ggtctatgag tggttgctgg ataacgtgcg taattgtgct gatctcttat      240

atagctgctc tcattatctc tctaccctga agtgactctc tcacctgtaa aaataatatc      300

tcacaggctt aatagtttct taatacaaag cctgtaaaac gtcaggataa cttctatatt      360

cagggagacc acaacggttt ccctctacaa ataattttgt ttaactttta taaaatacta      420

ttaaggagga tataatgtcg gacagtgaag tcaaccagga agcgaaaccg gaagtgaaac      480

cggaagtcaa acctgaaacg cacattaatc tgaaagtcag cgatggttcc agtgaaatct      540

tcttcaaaat taaaaaaact acgccgttac gtcgtttgat ggaagcattt gcgaaacgcc      600

agggcaagga aatggattcc ctccgcttct tatatgacgg gattcgtatc caagcagacc      660

aaaccccgga ggacctggac atggaagaca acgatattat tgaagcacat cgcgaacaga      720

ttgggggcgg gaacgcagca gctgcgcgtc gccgtcgccg ctgcattacg ggggatgcac      780

tggtcgcatt gcctgagggt gagagtgtgc gtattgcgga cattgtccct ggcgcgcgcc      840

ccaactccga taacgcaatc gatctgaagg tcctggaccg ccacggcaat cccgtattag      900

cagatcgttt attccattcg ggagaacatc cagtgtacac agtacgtact gtggaaggat      960

tacgtgtcac cggaactgca aatcatccgc tgttgtgctt ggtagatgtt gcaggagtgc     1020

ctacactgtt gtggaaactg atcgacgaga tcaaaccagg cgattacgct gtaatccagc     1080

gtagtgcgtt ttcggtggac tgcgcgggtt ttgcgcgtgg caaacctgag ttcgccccta     1140

cgacttatac tgttggagtg cctggtctgg tccgtttttt agaagctcac catcgcgacc     1200

cagacgctca ggccatcgct gatgagttga cagacggtcg cttctattac gcaaaggtag     1260

cgagtgtaac agacgcaggg gtgcaacctg tctacagttt gcgtgttgac acagcggacc     1320

acgcatttat caccaatggc ttcgtctcgc atgcgacggg attgaccggg cttaactctg     1380

gattgactga aaatctctat tttcagggca tgtccccgat cctgggttac tggaaaatca     1440

aagggttagt gcagccaacc cgtctgttat tagaatacct ggaggaaaaa tacgaggaac     1500

acctgtacga gcgcgatgaa ggcgataaat ggcgcaataa aaaattcgaa ctcgggctgg     1560

aattcccaaa cttaccctat tatattgatg gagatgttaa attgacccag tctatggcaa     1620

tcattcgcta tattgcagat aaacataaca tgttgggcgg ctgtcctaag gagcgcgcgg     1680

aaattagtat gctggaaggc gcggtgctgg atatccgcta tggtgttagc cgcattgcgt     1740

actcgaaaga ttttgagacg ctcaaagttg attttctgag taaactgcct gaaatgttaa     1800

agatgtttga agatcgcttg tgtcacaaaa cgtatttaaa tggtgatcat gtcacccatc     1860

cagactttat gctgtatgat gcgcttgatg tggttttgta catggatccg atgtgcctgg     1920

atgcctttcc gaagctggtc tgtttcaaaa aacgcatcga ggctattccg caaatcgaca     1980

aatatctcaa atctagtaaa tacatcgcgt ggcctctgca gggctggcaa gcgacctttg     2040

gtgggggcga tcatccgcca aaataatgaa ctgaccattt aaatcatacc tgacc          2095


<210>  34
<211>  8
<212>  PRT
<213>  synthetic


<220>
<221>  human-myristoyl transferase-1 recognition substrate
<222>  (1)..(8)
<223>  peptides with the sequence X1X2X3X4X5X6X7X8 where X1 is glycine, 
       X2 and X5 are small uncharged residues, but proline; X6 is any 
       residue but proline and X3, X4, X7 and X8 are any residues

<400>  34

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  35
<211>  98
<212>  PRT
<213>  synthetic


<220>
<221>  SUMO
<222>  (1)..(98)
<223>  where the starting amino acid on the peptide substrate is not 
       proline/where the amino acid following that sequence is not 
       proline

<400>  35

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly 
        


<210>  36
<211>  4889
<212>  DNA
<213>  synthetic

<400>  36
actgaccatt taaatcatac ctgacctcca tagcagaaag tcaaaagcct ccgaccggag       60

gcttttgact tgatcggcac gtaagaggtt ccaactttca ccataatgaa ataagatcac      120

taccgggcgt attttttgag ttatcgagat tttcaggagc taaggaagct aaaatgagcc      180

atattcaacg ggaaacgtct tgctcgaggc cgcgattaaa ttccaacatg gatgctgatt      240

tatatgggta taaatgggct cgcgataatg tcgggcaatc aggtgcgaca atctatcgat      300

tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca      360

atgatgttac agatgagatg gtcaggctaa actggctgac ggaatttatg cctcttccga      420

ccatcaagca ttttatccgt actcctgatg atgcatggtt actcaccact gcgatcccag      480

ggaaaacagc attccaggta ttagaagaat atcctgattc aggtgaaaat attgttgatg      540

cgctggcagt gttcctgcgc cggttgcatt cgattcctgt ttgtaattgt ccttttaacg      600

gcgatcgcgt atttcgtctc gctcaggcgc aatcacgaat gaataacggt ttggttggtg      660

cgagtgattt tgatgacgag cgtaatggct ggcctgttga acaagtctgg aaagaaatgc      720

ataagctttt gccattctca ccggattcag tcgtcactca tggtgatttc tcacttgata      780

accttatttt tgacgagggg aaattaatag gttgtattga tgttggacga gtcggaatcg      840

cagaccgata ccaggatctt gccatcctat ggaactgcct cggtgagttt tctccttcat      900

tacagaaacg gctttttcaa aaatatggta ttgataatcc tgatatgaat aaattgcagt      960

ttcacttgat gctcgatgag tttttctaat gagggcccaa atgtaatcac ctggctcacc     1020

ttcgggtggg cctttctgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     1080

atcacaaaaa tcgatgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     1140

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     1200

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     1260

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     1320

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     1380

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     1440

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     1500

ttggtatctg cgctctgctg aagccagtta cctcggaaaa agagttggta gctcttgatc     1560

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     1620

cagaaaaaaa ggatctcaag aagatccttt gattttctac cgaagaaagg cccacccgtg     1680

aaggtgagcc agtgagttga ttgcagtcca gttacgctgg agtctgccca ggcatcaaat     1740

aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt tgtcggtgaa     1800

cgctctctac tagagtcaca ctggctcacc ttcgggtggg cctttctgcg tttatacaca     1860

gctaacacca cgtcgtccct atctgctgcc ctaggtctat gagtggttgc tggataacgt     1920

gcgtaattgt gctgatctct tatatagctg ctctcattat ctctctaccc tgaagtgact     1980

ctctcacctg taaaaataat atctcacagg cttaatagtt tcttaataca aagcctgtaa     2040

aacgtcagga taacttctat attcagggag accacaacgg tttccctcta caaataattt     2100

tgtttaactt taaagaggag aaatactaga tgtcggacag tgaagtcaac caggaagcga     2160

aaccggaagt gaaaccggaa gtcaaacctg aaacgcacat taatctgaaa gtcagcgatg     2220

gttccagtga aatcttcttc aaaattaaaa aaactacgcc gttacgtcgt ttgatggaag     2280

catttgcgaa acgccagggc aaggaaatgg attccctccg cttcttatat gacgggattc     2340

gtatccaagc agaccaaacc ccggaagatc tggacatgga agacaacgat attattgaag     2400

cacatcgcga acagattggg ggcgggaacg cagcatctgc gcgccgcgaa aatctctatt     2460

ttcagggcat gtccccgatc ctgggttact ggaaaatcaa agggttagtg cagccaaccc     2520

gtctgttatt agaatacctg gaggaaaaat acgaggaaca cctgtacgag cgcgatgaag     2580

gcgataaatg gcgcaataaa aaattcgaac tcgggctgga attcccaaac ttaccctatt     2640

atattgatgg agatgttaaa ttgacccagt ctatggcaat cattcgctat attgcagata     2700

aacataacat gttgggcggc tgtcctaagg agcgcgcgga aattagtatg ctggaaggcg     2760

cggtgctgga tatccgctat ggtgttagcc gcattgcgta ctcgaaagat tttgagacgc     2820

tcaaagttga ttttctgagt aaactgcctg aaatgttaaa gatgtttgaa gatcgcttgt     2880

gtcacaaaac gtatttaaat ggtgatcatg tcacccatcc agactttatg ctgtatgatg     2940

cgcttgatgt ggttttgtac atggatccga tgtgcctgga tgcctttccg aagctggtct     3000

gtttcaaaaa acgcatcgag gctattccgc aaatcgacaa atatctcaaa tctagtaaat     3060

acatcgcgtg gcctctgcag ggctggcaag cgacctttgg tgggggcgat catccgccaa     3120

aatgataatc gcgcaaaaaa ccccgcttcg gcggggtttt ttcgcacgtc tccatcgctt     3180

gcccaagttg tgaagcacag ctaacaccac gtcgtcccta tctgctgccc taggtctatg     3240

agtggttgct ggataacgcc acggaaatca ataacctgaa gatatgtgcg acgagctttt     3300

cataaatctg tcataaatct gacgcataat gacgtcgcat taatgatcgc aacctattta     3360

ttatattcag ggagaccaca acggtttccc tctacaaata attttgttta actttgcttc     3420

aatctaaatt agtaaggagg tagtcaatga caaatcctgg tgtaagtgcc tggcaagtta     3480

ataccgcata taccgctggg cagttagtca cttataacgg caagacctac aagtgcttgc     3540

agcctcacac atccttggca ggttgggaac cgtccaatgt acccgccctt tggcaacttc     3600

agggctctgc cggtagtgcg gcgggttccg gtgaatttaa ctcgttgcct gctgagcgta     3660

tccaagaaat tcagaaggca attgaactgt ttagcgtggg tcaaggccca gccaaaacga     3720

tggaggaagc gagcaaacgt tcgtatcagt tctgggatac gcaaccggtg ccgaagctcg     3780

gtgaagtggt gaatacgcac gggcctgttg agccggataa ggacaatatt cgtcaggagc     3840

catatacgct gcctcagggt ttcacttggg acgccctgga cctgggtgac cgtggtgtgc     3900

tgaaagaact gtacaccctg cttaatgaga attatgtaga agatgacgac aacatgttcc     3960

gttttgacta tagcccggaa ttcctgttat gggcactccg tccgccgggt tggctgccgc     4020

agtggcattg cggtgtccgc gtagtttcga gccgtaaact cgtaggtttc atcagtgcaa     4080

tcccggccaa cattcatatc tatgacaccg agaaaaaaat ggtagaaatt aacttcctgt     4140

gtgttcataa gaagttgcgt agcaaacgcg tagcgcctgt cctcattcgt gaaatcacgc     4200

gccgcgtaca tttagaaggt atcttccagg cagtatatac tgctggcgtc gtgctcccaa     4260

aaccggttgg gacttgccgc tattggcacc gctctctgaa tccgcgtaag ctgattgaag     4320

ttaaatttag ccatttgtca cgcaacatga ccatgcagcg caccatgaaa ctttaccgtc     4380

tgccggaaac cccgaaaact gctggtttgc gcccaatgga gacgaaagat attcctgtcg     4440

tccatcagct gctgacgcgt tatttaaaac agtttcactt aactcctgtc atgagccagg     4500

aagaggttga acattggttt tatccgcaag aaaacatcat cgacaccttc gtagtggaga     4560

atgcgaatgg cgaagtcacg gactttttat ccttctatac tttgccgagc accatcatga     4620

accatccgac ccataaaagc ctgaaggccg cgtactcatt ttataatgtc cacacgcaga     4680

ccccgttatt ggatctgatg tctgatgcgt tggtcctggc caaaatgaaa ggtttcgacg     4740

tttttaatgc gctggacctg atggagaaca aaacctttct ggaaaaattg aaattcggaa     4800

ttggcgatgg taatctgcaa tactatctgt ataattggaa atgcccgtcg atgggtgcgg     4860

aaaaagttgg tctggtactg cagtagtaa                                       4889


<210>  37
<211>  8
<212>  PRT
<213>  synthetic


<220>
<221>  exemplary human-myristoyl transferase-1 recognition substrate
<222>  (1)..(8)
<223>  peptides with the sequence X1X2X3X4X5X6X7X8 where X1 is glycine, 
       X2 and X5 are small uncharged residues, but proline; X6 is any 
       residue but proline and X3, X4, X7 and X8 are any residues

<400>  37

Gly Asn Ala Ala Ala Ala Arg Arg 
1               5               


