                               SEQUENCE LISTING

<110> URIGEN N.A
 
<120> TREATMENT OF LOWER URINARY TRACT EPITHELIUM WITH GLUCAGON 
      LIKE PEPTIDE 2

<130> 160956-010201PCT

<140>
<141>

<150> 62/463,923
<151> 2017-02-27

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 33
<212> PRT
<213> Homo sapiens

<400> 1
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 2
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 3
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg, Lys, His, or absent

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg, Lys, His, or absent 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> His or Tyr 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Ala or an Ala-replacement amino acid conferring on said analog 
      resistance to DPP-IV enzyme 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Asp or Glu 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Gly or Ala 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Glu or Tyr 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ser if position 11 is Tyr, otherwise Met or an oxidatively 
      stable Met replacement amino acid 

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Lys if position 11 is Tyr, or Asn 

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Tyr if position 11 is Tyr, or Thr 

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Ile, or Xaa is not present if position 11 is Tyr 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala or Thr 

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Arg, Lys, His, or Ala 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ile or Val 

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Asn or Ala if position 25 is Ile, Gln if position 25 is Val 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ile or a covalent bond 

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Thr if position 34 is Ile, or a covalent bond 

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Asp if position 35 is Thr, or a covalent bond 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Arg, Lys, His, or absent 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Arg, Lys, His, or absent 

<400> 3
Xaa Xaa Xaa Xaa Xaa Xaa Ser Phe Ser Asp Xaa Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Asp Asn Leu Ala Xaa Xaa Asp Phe Xaa Xaa Trp Leu Ile Gln Thr Lys 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa 
        35          


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Met or an oxidatively stable Met replacement 

<400> 4
Glu Xaa Asn Thr Ile 
1               5   


<210> 5
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GLP-2 analogue 

<400> 5
Tyr Ser Lys Tyr 
1               


<210> 6
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or absent

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg or absent

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Neutral/polar/large/nonaromatic residue such as Ile or Val 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Neutral/polar residue such as Asn or Ser 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Neutral residue such as Ala or Thr

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Neutral/polar/large/nonaromatic residue such as Ile or Leu 

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Neutral or basic residue such as Gln or His 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Lys or absent

<400> 6
Xaa Xaa His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Xaa Leu 
1               5                   10                  15      


Asp Xaa Leu Ala Xaa Arg Asp Phe Ile Asn Trp Leu Xaa Xaa Thr Lys 
            20                  25                  30          


Ile Thr Asp Xaa Xaa 
        35          


<210> 7
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Arg or absent

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Arg or absent

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Neutral residue such as Ala or Thr 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Lys or absent 

<400> 7
Xaa Xaa His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu 
1               5                   10                  15      


Asp Asn Leu Ala Xaa Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30          


Ile Thr Asp Xaa Xaa 
        35          


<210> 8
<211> 33
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GLP-2 analogue 

<400> 8
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Thr Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 9
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> His, Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (2)..(2)
<223> His, Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Met, Leu, Ile, Val, or Cys 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Ala, Ser, Thr, Pro, Gly, Asn, Asp, Glu, or Gln

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ser, Thr, Pro, or Gly

<220>
<221> MOD_RES
<222> (22)..(22)
<223> His, Arg, or Lys 

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Met, Leu, Ile, Val, or Cys 

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Asn, Asp, Glu, Gln, His, Arg, or Lys 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> His, Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> His, Arg, Lys, or absent 

<400> 9
Xaa Xaa His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Xaa Leu 
1               5                   10                  15      


Asp Xaa Leu Ala Xaa Xaa Asp Phe Ile Asn Trp Leu Xaa Xaa Thr Lys 
            20                  25                  30          


Ile Thr Asp Xaa Xaa 
        35          


<210> 10
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> His, Arg, Lys, or absent

<220>
<221> MOD_RES
<222> (2)..(2)
<223> His, Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ala, Ser, Thr, Pro, or Gly 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> His, Arg, Lys, or absent 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> His, Arg, Lys, or absent 

<400> 10
Xaa Xaa His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu 
1               5                   10                  15      


Asp Asn Leu Ala Xaa Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys 
            20                  25                  30          


Ile Thr Asp Xaa Xaa 
        35          


<210> 11
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 11
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 12
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 12
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Ile Phe Ile Ala Trp Leu Ile Ala Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 13
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 13
His Gly Asp Gly Ser Pro Ser Asp Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 14
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 14
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 15
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 15
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 16
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 16
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 17
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 17
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 18
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 18
His Gly Asp Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 19
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 19
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 20
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 20
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 21
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 21
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 22
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 22
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 23
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 23
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 24
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 24
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 25
His Gly Asp Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 26
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 26
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 27
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 27
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 28
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 28
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 29
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 29
His Gly Asp Gly Ser Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys 
        35  


<210> 30
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 30
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 31
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 31
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 32
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 32
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 33
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 33
His Gly Asp Gly Ser Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 34
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 34
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 35
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 35
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 36
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 36
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 37
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 37
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 38
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 38
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 39
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 39
His Gly Asp Gly Ser Phe Ser Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 40
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 40
His Gly Asp Gly Ser Phe Thr Ser Glu Leu Lys Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 41
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 41
His Gly Asp Gly Ser Phe Thr Asp Glu Leu Ala Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln Thr Lys 
            20                  25                  30  


<210> 42
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 42
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 43
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 43
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 44
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 44
His Gly Glu Gly Ser Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 45
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 45
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 46
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 46
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 47
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 47
His Gly Glu Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 48
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 48
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 49
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 49
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 50
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 50
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp Lys Lys Lys Lys Lys Lys 
        35                  


<210> 51
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 51
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 52
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 52
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 53
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 53
His Gly Glu Gly Ser Phe Ser Ser Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 54
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 54
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Ser Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 55
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 55
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 56
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 56
His Gly Glu Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 57
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 57
His Gly Glu Gly Ser Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 58
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 58
His Gly Glu Gly Thr Phe Ser Asp Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 59
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue

<400> 59
His Gly Glu Gly Thr Phe Ser Ser Glu Leu Lys Thr Ile Leu Asp Ala 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 60
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue


<220>
<221> MOD_RES
<222> (1)..(20)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, His,
      Met, Orn, or absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Gly, Ala or Sar 

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Glu or Asp 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Phe or Pro 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp or Ser 

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Glu or Asp 

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Met, Leu, Nle, or an oxidatively stable Met-replacement 
      amino acid 

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asn, Ala, Lys, or Ser 

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Thr or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ile, Glu or Gln 

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Leu, Met, or Nle 

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Asp or Glu 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Asn or Ala 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Leu or Glu 

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Ala or Aib 

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Ala or Thr 

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Arg or Lys 

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Asp or Ile 

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Asn, Ala, or Glu 

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Gln, Ala, or Asn 

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Pro Ile, or absent 

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Thr or absent 

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Asp, Asn, or absent 

<220>
<221> MOD_RES
<222> (54)..(73)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, 
      His, Met, Orn, or absent 

<400> 60
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ile Xaa Trp Leu Ile Xaa 
        35                  40                  45              


Thr Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70              


<210> 61
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue


<220>
<221> MOD_RES
<222> (1)..(20)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, 
      His, Met, Orn, or absent 

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Glu or Asp 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp or Ser 

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Glu or Asp 

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Met, Leu, Nle, or an oxidatively stable Met-replacement 
      amino acid 

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asn, Ala, Lys or Ser 

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Thr or Lys 

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Ile, Glu, or Gln 

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Leu, Met or Nle 

<220>
<221> MOD_RES
<222> (35)..(35)
<223> Asp or Glu 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Asn or Ala 

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Leu or Glu 

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Ala or Thr 

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Asn or Ala 

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Gln, Ala, or Asn 

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Pro, Ile, or absent 

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Thr or absent 

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Asp or absent 

<220>
<221> MOD_RES
<222> (54)..(73)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, 
      His, Met, Orn, or absent 

<400> 61
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Gly Xaa Gly Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Ala Xaa Arg Asp Phe Ile Xaa Trp Leu Ile Xaa 
        35                  40                  45              


Thr Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70              


<210> 62
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<223> GLP-2 analogue


<220>
<221> MOD_RES
<222> (1)..(20)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln,  Asp, Glu, Lys, Arg, 
      His, Met, Orn, or absent 

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Glu or Asp 

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Ser or Thr 

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Asp or Ser 

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Met, Leu, Nle, or an oxidatively stable Met-replacement 
      amino acid 

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Asn, Ala, Lys, or Ser 

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Asn or Ala 

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Asn or Ala 

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Gln or Ala 

<220>
<221> MOD_RES
<222> (51)..(51)
<223> Pro or absent 

<220>
<221> MOD_RES
<222> (52)..(52)
<223> Thr or absent 

<220>
<221> MOD_RES
<222> (53)..(53)
<223> Asp or absent 

<220>
<221> MOD_RES
<222> (54)..(73)
<223> Ala, Leu, Ser, Thr, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, 
      His, Met, Orn, or absent 

<400> 62
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Gly Xaa Gly Xaa Phe Xaa Xaa Glu Xaa Xaa Thr 
            20                  25                  30          


Ile Leu Asp Xaa Leu Ala Ala Arg Asp Phe Ile Xaa Trp Leu Ile Xaa 
        35                  40                  45              


Thr Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70              


<210> 63
<211> 34
<212> PRT
<213> Homo sapiens

<400> 63
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Arg 
        


