                               SEQUENCE LISTING

<110> FLUGEN, INC.
 
<120> IMMUNOGENIC COMPOSITIONS AGAINST INFLUENZA

<130> 090248-0163

<140> PCT/US2018/019653
<141> 2018-02-26

<150> 62/464,019
<151> 2017-02-27

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 976
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgtact       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctagacaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgattaata ggatcgtctt tttttcaaat gcatttaccg tcgctttaaa tacggactga      840

aaggagggcc ttctacggaa ggagtgccaa agtctatgag ggaagaatat cgaaaggaac      900

agcagagtgc tgtggatgct gacgatggtc attttgtcag catagagctg gagtaaaaaa      960

ctaccttgtt tctact                                                      976


<210> 2
<211> 1027
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cctacgtact       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctagacaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgattaata gactattgcc gcaaatatca ttgggatctt gcacttgaca ttgtggattc      840

ttgatcgtct ttttttcaaa tgcatttacc gtcgctttaa atacggactg aaaggagggc      900

cttctacgga aggagtgcca aagtctatga gggaagaata tcgaaaggaa cagcagagtg      960

ctgtggatgc tgacgatggt cattttgtca gcatagagct ggagtaaaaa actaccttgt     1020

ttctact                                                               1027


<210> 3
<211> 976
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cctacgtact       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctagacaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgattaata ggatcgtctt tttttcaaat gcatttaccg tcgctttaaa tacggactga      840

aaggagggcc ttctacggaa ggagtgccaa agtctatgag ggaagaatat cgaaaggaac      900

agcagagtgc tgtggatgct gacgatggtc attttgtcag catagagctg gagtaaaaaa      960

ctaccttgtt tctact                                                      976


<210> 4
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp 
            20                  


<210> 5
<211> 1027
<212> DNA
<213> Influenza A virus

<400> 5
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgtact       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctagacaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgatcctct cactattgcc gcaaatatca ttgggatctt gcacttgaca ttgtggattc      840

ttgatcgtct ttttttcaaa tgcatttacc gtcgctttaa atacggactg aaaggagggc      900

cttctacgga aggagtgcca aagtctatga gggaagaata tcgaaaggaa cagcagagtg      960

ctgtggatgc tgacgatggt cattttgtca gcatagagct ggagtaaaaa actaccttgt     1020

ttctact                                                               1027


<210> 6
<211> 861
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata aattcaattt      780

ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca aataaactgg      840

aaaaagtgcg ttgtttctac t                                                861


<210> 7
<211> 904
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaattcaa tttttactgt acttcttact      840

atgcatttaa gcaaattgta atcaatgtca gcaaataaac tggaaaaagt gcgttgtttc      900

tact                                                                   904


<210> 8
<211> 904
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggag tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaattcaa tttttactgt acttcttact      840

atgcatttaa gcaaattgta atcaatgtca gcaaataaac tggaaaaagt gcgttgtttc      900

tact                                                                   904


<210> 9
<211> 1111
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaaagggg ccaaataaag agacaataaa      840

cagagaggta tcaattttga gacacagtta ccaaaaagaa atccaggcca aagaagcaat      900

gaaggaagta ctctctgaca acatggaggt attgagtgac cacatagtaa ttgaggggct      960

ttctgctgaa gagataataa aaatgggtga aacagttttg gaggtagaag aattgcatta     1020

aattcaattt ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca     1080

aataaactgg aaaaagtgcg ttgtttctac t                                    1111


<210> 10
<211> 1111
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggag tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaaagggg ccaaataaag agacaataaa      840

cagagaggta tcaattttga gacacagtta ccaaaaagaa atccaggcca aagaagcaat      900

gaaggaagta ctctctgaca acatggaggt attgagtgac cacatagtaa ttgaggggct      960

ttctgctgaa gagataataa aaatgggtga aacagttttg gaggtagaag aattgcatta     1020

aattcaattt ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca     1080

aataaactgg aaaaagtgcg ttgtttctac t                                    1111


<210> 11
<211> 862
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcactaatag aagatggaga aggcaaagca gaactagctg aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agattctgct ttggaatgga taaaaaacaa aaggtgccta      180

actgatatac aaaaagcact aattggtgcc tctatatgct ttttaaaacc caaagaccaa      240

gaaagaaaaa ggagattcat cacagagccc ctgtcaggaa tgggaacaac agcaacaaag      300

aagaaaggcc taattctagc tgagagaaaa atgagaagat gtgtaagctt tcatgaagca      360

tttgaaatag cagaaggcca cgaaagctca gcattactat attgtcttat ggtcatgtac      420

ctaaaccctg aaaactattc aatgcaagta aaactaggaa cgctctgtgc tttatgcgag      480

aaacaagcat cgcactcgca tagagcccat agcagagcag caaggtcttc ggtacctgga      540

gtaagacgag aaatgcagat ggtttcagct atgaacacag caaagacaat gaatggaatg      600

ggaaagggag aagacgtcca aaaactagca gaagagctgc aaaacaacat tggagtgttg      660

agatctctag gagcaagtca aaagaatgga gaaggaattg ccaaagatgt aatggaagtg      720

ctaaaacaga gctctatggg aaattcagct cttgtgagga aatacttata agcccaattt      780

tcactgtatt tcttactatg catttaagca aattgtaatc aatgtcagtg aataaaactg      840

gaaaaagtgc gttgtttcta ct                                               862


<210> 12
<211> 1191
<212> DNA
<213> Influenza B virus

<400> 12
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcactaatag aagatggaga aggcaaagca gaactagctg aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agattctgct ttggaatgga taaaaaacaa aaggtgccta      180

actgatatac aaaaagcact aattggtgcc tctatatgct ttttaaaacc caaagaccaa      240

gaaagaaaaa ggagattcat cacagagccc ctgtcaggaa tgggaacaac agcaacaaag      300

aagaaaggcc taattctagc tgagagaaaa atgagaagat gtgtaagctt tcatgaagca      360

tttgaaatag cagaaggcca cgaaagctca gcattactat attgtcttat ggtcatgtac      420

ctaaaccctg aaaactattc aatgcaagta aaactaggaa cgctctgtgc tttatgcgag      480

aaacaagcat cgcactcgca tagagcccat agcagagcag caaggtcttc ggtacctgga      540

gtaagacgag aaatgcagat ggtttcagct atgaacacag caaagacaat gaatggaatg      600

ggaaagggag aagacgtcca aaaactagca gaagagctgc aaaacaacat tggagtgttg      660

agatctctag gagcaagtca aaagaatgga gaaggaattg ccaaagatgt aatggaagtg      720

ctaaaacaga gctctatggg aaattcagct cttgtgagga aatacttata atgctcgaac      780

cacttcagat tctttcaatt tgttctttca ttttatcagc tctccatttc atggcttgga      840

caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa ataaggaatc      900

caaataagga ggcaataaac agagaggtgt caattctgag acacaattac caaaaggaaa      960

tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta ttgggtgacc     1020

acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa acagttttgg     1080

aggtggaaga attgcaatga gcccaatttt cactgtattt cttactatgc atttaagcaa     1140

attgtaatca atgtcagtga ataaaactgg aaaaagtgcg ttgtttctac t              1191


<210> 13
<211> 294
<212> DNA
<213> Influenza A virus

<400> 13
atgagtcttc taaccgaggt cgaaacgcct atcagaaacg aatgggggtg cagatgcaac       60

ggttcaagtg atcctctcac tattgccgca aatatcattg ggatcttgca cttgacattg      120

tggattcttg atcgtctttt tttcaaatgc atttaccgtc gctttaaata cggactgaaa      180

ggagggcctt ctacggaagg agtgccaaag tctatgaggg aagaatatcg aaaggaacag      240

cagagtgctg tggatgctga cgatggtcat tttgtcagca tagagctgga gtaa            294


<210> 14
<211> 421
<212> DNA
<213> Influenza B virus

<400> 14
atgctcgaac cacttcagat tctttcaatt tgttctttca ttttatcagc tctccatttc       60

atggcttgga caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa      120

ataaggaatc caaataagga ggcaataaac agagaggtgt caattctgag acacaattac      180

caaaaggaaa tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta      240

ttgggtgacc acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa      300

acagttttgg aggtggaaga attgcaatga gcccaatttt cactgtattt cttactatgc      360

atttaagcaa attgtaatca atgtcagtga ataaaactgg aaaaagtgcg ttgtttctac      420

t                                                                      421


