                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer and Research Institute, Inc.
 
<120>  BISPECIFIC ANTIBODY FOR CANCER IMMUNOTHERAPY

<130>  10110-171WO1

<140>  PCT/US2018/019181
<141>  2018-02-22

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gln Val Gln Leu Gln 
            20                  25                  30          


Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser 
        35                  40                  45              


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val 
    50                  55                  60                  


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
65                  70                  75                  80  


Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
                85                  90                  95      


Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            100                 105                 110         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp 
        115                 120                 125             


Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                165                 170                 175     


Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            180                 185                 190         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        195                 200                 205             


Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala 
225                 230                 235                 240 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe 
                245                 250                 255     


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            260                 265             


<210>  2
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Gln Val Gln Leu Gln 
            20                  25                  30          


Gln Ser Gly Thr Glu Leu Val Lys Pro Ala Ser Ser Val Lys Ile Ser 
        35                  40                  45              


Cys Lys Ala Ser Gly Tyr Thr Ser Thr Ser Asn Tyr Met His Trp Ile 
    50                  55                  60                  


Arg Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro 
65                  70                  75                  80  


Gly Asn Gly Asn Thr Lys Tyr Asn Gln Lys Phe Asp Gly Lys Ala Thr 
                85                  90                  95      


Pro Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Arg 
            100                 105                 110         


Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ala Pro Leu 
        115                 120                 125             


Asp Tyr Gly Gly His Ile Met Asp Ala Trp Gly Gln Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ala Phe Leu Ser Ala 
                165                 170                 175     


Ser Leu Gly Glu Thr Val Ser Ile Glu Cys Leu Gly Ser Glu Asp Ile 
            180                 185                 190         


Tyr Gly Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln 
        195                 200                 205             


Leu Leu Ile Tyr Val Ala Asn Arg Leu Gln Asp Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly 
225                 230                 235                 240 


Met Gln Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Leu Gln Gly Ser Lys 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            260                 265                 270     


<210>  3
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Ala Ile Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro Thr 
1               5                   10                  15      


Ser Leu Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly Tyr 
            20                  25                  30          


Arg Val Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu Ile 
        35                  40                  45              


Asn Leu Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met Val 
    50                  55                  60                  


Ala Thr Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu Thr 
65                  70                  75                  80  


Ser Arg Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser Pro 
                85                  90                  95      


Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr Ile 
            100                 105                 110         


Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp Ala 
        115                 120                 125             


Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro Asp 
    130                 135                 140                 


Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr Lys 
145                 150                 155                 160 


Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val Val 
                165                 170                 175     


Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe Leu 
            180                 185                 190         


Ala Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg Ala 
        195                 200                 205             


Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro Pro 
    210                 215                 220                 


Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr Ile 
225                 230                 235                 240 


Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala Leu 
                245                 250                 255     


Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr 
            260                 265                 270     


