                         SEQUENCE LISTING

<110>  MeiraGTx UK II Limited
       Guo, Xuecui
       Han, Joonhee
       Zhong, Zhaojing
 
<120>  REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED ACCESSIBILITY 
       OF POLYADENYLATION SIGNALS

<130>  162027.48676

<150>  US 62/461,689
<151>  2017-02-21

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttctaaag gtataatcgc gtggatatgg cacgcaagtt tctaccgggc accgtaaatg      240

tccgactacc tttatttcga aagaaataaa gcattttttt cactgcattc tagttgtggt      300

ttgtccaaac tcatcaatgt atcttaacgc gt                                    332


<210>  2
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcacata aagcataatc gcgtggatat ggcacgcaag tttctaccgg gcaccgtaaa      240

tgtccgactg ctttatttcg aaagaaataa agcatttttt tcactgcatt ctagttgtgg      300

tttgtccaaa ctcatcaatg tatcttaacg cgt                                   333


<210>  3
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttaataaa gataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt      240

ccgactcttt atttgtgcga aagcacaaat aaagcatttt tttcactgca ttctagttgt      300

ggtttgtcca aactcatcaa tgtatcttaa cgcgt                                 335


<210>  4
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

attttaaagc aataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt      240

ccgacttgct ttatttgtgc gaaagcacaa ataaagcatt tttttcactg cattctagtt      300

gtggtttgtc caaactcatc aatgtatctt aacgcgt                               337


<210>  5
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc gaaaggacaa      240

accataatcg cgtggatatg gcacgcaagt ttctaccggg caccgtaaat gtccgactgg      300

tttgtaaact catcaatgta tcttaacgcg t                                     331


<210>  6
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc gaaaggacaa      240

accaataatc gcgtggatat ggcacgcaag tttctaccgg gcaccgtaaa tgtccgactt      300

ggtttgaaac tcatcaatgt atcttaacgc gt                                    332


<210>  7
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc gaaaggacaa      240

accacaataa tcgcgtggat atggcacgca agtttctacc gggcaccgta aatgtccgac      300

ttgtggttta aactcatcaa tgtatcttaa cgcgt                                 335


<210>  8
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc gaaaggacaa      240

accacaacat aatcgcgtgg atatggcacg caagtttcta ccgggcaccg taaatgtccg      300

actgttgtgg aaactcatca atgtatctta acgcgt                                336


<210>  9
<211>  158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
aaggccaaga agggcggaaa gatcgccgtg taaggatcca agcttatcga taccgtcgac       60

ctcgagggcc cagatctgcg gccgcaataa aagatcttta ttttcattag atctgtgtgt      120

tggttttttg tgtgtctaga aataattctt actgtcat                              158


<210>  10
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
aaggccaaga agggcggaaa gatcgccgtg taaggatcca agcttatcga taccgtcgac       60

ctcgagggcc cagatctgcg gcaaaaggta taatcgcgtg gatatggcac gcaagtttct      120

accgggcacc gtaaatgtcc gactaccttt tattggaaac aataaaagat ctttattttc      180

attagatctg tgtgttggtt ttttgtgtgt ctagaaataa ttcttact                   228


<210>  11
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
aaggccaaga agggcggaaa gatcgccgtg taaggatcca agcttatcga taccgtcgac       60

ctcgagggcc cagatctgcg gccgcaataa aagatcttta ttttcattag atctgtgtgt      120

tggttttttg tgtgtcgaaa gacacacaat ataatcgcgt ggatatggca cgcaagtttc      180

taccgggcac cgtaaatgtc cgactattgt gtggaaataa ttcttact                   228


<210>  12
<211>  153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
aaggccaaga agggcggaaa gatcgccgtg taaggatcca agcttatcga taccgtcgac       60

ctcgagggcc cagatctgcg gccgcaataa aatatcttta ttttcattac atctgtgtgt      120

tggttttttg tgtgtctaga aataattctt act                                   153


<210>  13
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
aaggccaaga agggcggaaa gatcgccgtg taaggatcca agcttatcga taccgtcgac       60

ctcgagggcc cagatctgcg gaaaaggtat aatcgcgtgg atatggcacg caagtttcta      120

ccgggcaccg taaatgtccg actacctttt attgcgaaag caataaaata tctttatttt      180

cattacatct gtgtgttggt tttttgtgtg tctagaaata attcttact                  229


<210>  14
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttctaaag gtataatcgc gtggatatgg cacgcaagtt tctaccgggc accgtaaatg      240

tccgactacc tttatttctt cggaaataaa gcattttttt cactgcattc tagttgtggt      300

ttgtccaaac tcatcaatgt atcttaacgc gt                                    332


<210>  15
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttctaaag gtataatcgc gtggatatgg cacgcaagtt tctaccgggc accgtaaatg      240

tccgactacc tttatttcga atgaaataaa gcattttttt cactgcattc tagttgtggt      300

ttgtccaaac tcatcaatgt atcttaacgc gt                                    332


<210>  16
<211>  407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttctaaag gtataatcgc gtggatatgg cacgcaagtt tctaccgggc accgtaaatg      240

tccgactacc tttatttcga aagaaataaa gcattttttt cactgcattc tagttgtggt      300

ttgtccgaaa ggacaaacca taatcgcgtg gatatggcac gcaagtttct accgggcacc      360

gtaaatgtcc gactggtttg taaactcatc aatgtatctt aacgcgt                    407


<210>  17
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
aaggccaaga agggcggaaa gatcgccgtg taagccatac cacatttgta gaggttttac       60

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg      120

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa      180

atttcaataa aggtataacc tcaataatat ggtttgaggg tgtctaccag gaaccgtaaa      240

atcctgatta cctttatttc ttcggaaata aagcattttt ttcactgcat tctagttgtg      300

gtttgtccaa actcatcaat gtatcttaac gcgt                                  334


