                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF MICHIGAN
 
<120>  IL-22BP COMPOSITIONS AND METHOD FOR THE TREATMENT OF DISEASE 
       THEREWITH

<130>  UM-35146/WO-1/ORD

<150>  US 62/461,543
<151>  2017-02-21

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
65                  70                  75                  80  


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
                85                  90                  95      


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
            100                 105                 110         


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
        115                 120                 125             


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
    130                 135                 140                 


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
145                 150                 155                 160 


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
                165                 170                 175     


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
            180                 185                 190         


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
        195                 200                 205             


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
    210                 215                 220                 


Glu Arg Cys Val Glu Ile Pro 
225                 230     


<210>  2
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  2

Met Met Pro Lys His Cys Leu Leu Gly Leu Leu Ile Ile Leu Leu Ser 
1               5                   10                  15      


Ser Ala Thr Ala Leu Glu Ile Gln Pro Ala Arg Val Ser Leu Thr Pro 
            20                  25                  30          


Gln Lys Val Arg Phe Gln Ser Arg Asn Phe His Asn Ile Leu His Trp 
        35                  40                  45              


Gln Ala Gly Ser Ser Leu Pro Ser Asn Asn Ser Ile Tyr Phe Val Gln 
    50                  55                  60                  


Tyr Lys Met Tyr Gly Gln Ser Gln Trp Glu Asp Lys Val Asp Cys Trp 
65                  70                  75                  80  


Gly Thr Thr Ala Leu Phe Cys Asp Leu Thr Asn Glu Thr Leu Asp Pro 
                85                  90                  95      


Tyr Glu Leu Tyr Tyr Gly Arg Val Met Thr Ala Cys Ala Gly Arg His 
            100                 105                 110         


Ser Ala Trp Thr Arg Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys 
        115                 120                 125             


Leu Asp Pro Pro Val Val Thr Ile Thr Arg Val Asn Ala Ser Leu Arg 
    130                 135                 140                 


Val Leu Leu Arg Pro Pro Glu Leu Pro Asn Arg Asn Gln Ser Gly Lys 
145                 150                 155                 160 


Asn Ala Ser Met Glu Thr Tyr Tyr Gly Leu Val Tyr Arg Val Phe Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Glu Lys Glu Gln Lys Ala Tyr Glu Gly Thr Gln 
            180                 185                 190         


Arg Ala Val Glu Ile Glu Gly Leu Ile Pro His Ser Ser Tyr Cys Val 
        195                 200                 205             


Val Ala Glu Met Tyr Gln Pro Met Phe Asp Arg Arg Ser Pro Arg Ser 
    210                 215                 220                 


Lys Glu Arg Cys Val Gln Ile Pro 
225                 230         


<210>  3
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (104)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (110)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (133)..(134)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (143)..(143)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (145)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (147)..(148)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(158)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (186)..(186)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (190)..(191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (229)..(229)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Met Pro Lys His Cys Xaa Leu Gly Xaa Leu Ile Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Ser Leu Xaa Pro Gln 
            20                  25                  30          


Xaa Val Xaa Phe Gln Ser Arg Asn Phe His Asn Ile Leu Xaa Trp Gln 
        35                  40                  45              


Xaa Gly Xaa Xaa Leu Xaa Xaa Asn Xaa Ser Xaa Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Xaa Tyr Gly Gln Xaa Gln Trp Xaa Xaa Lys Xaa Asp Cys Trp Gly 
65                  70                  75                  80  


Thr Xaa Xaa Leu Xaa Cys Asp Leu Thr Xaa Glu Thr Xaa Asp Xaa Xaa 
                85                  90                  95      


Glu Xaa Tyr Tyr Gly Arg Val Xaa Xaa Ala Xaa Ala Gly Xaa Xaa Ser 
            100                 105                 110         


Xaa Trp Xaa Xaa Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Xaa 
        115                 120                 125             


Asp Pro Pro Val Xaa Xaa Ile Thr Xaa Val Asn Xaa Ser Leu Xaa Val 
    130                 135                 140                 


Xaa Leu Xaa Xaa Pro Xaa Leu Pro Xaa Arg Xaa Gln Xaa Xaa Lys Asn 
145                 150                 155                 160 


Xaa Ser Xaa Glu Xaa Tyr Tyr Xaa Leu Xaa Tyr Arg Val Phe Xaa Ile 
                165                 170                 175     


Asn Asn Ser Leu Glu Lys Glu Gln Lys Xaa Tyr Glu Gly Xaa Xaa Arg 
            180                 185                 190         


Ala Val Glu Ile Glu Xaa Leu Xaa Pro His Ser Ser Tyr Cys Val Val 
        195                 200                 205             


Ala Glu Xaa Tyr Gln Pro Met Xaa Asp Arg Arg Ser Xaa Arg Ser Xaa 
    210                 215                 220                 


Glu Arg Cys Val Xaa Ile Pro 
225                 230     


<210>  4
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic rigid linker

<400>  5

Pro Ala Pro Ala Pro 
1               5   


<210>  6
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic flexible linker

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


