                         SEQUENCE LISTING

<110>  KINDRED BIOSCIENCES, INC.
 
<120>  ANTI-IL31 ANTIBODIES FOR VETERINARY USE

<130>  01157-0007-01PCT

<150>  US 62/463,543
<151>  2017-02-24

<150>  PCT/US2017/023788
<151>  2017-03-23

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Variable heavy chain CDR-H1 amino acid sequence of mouse antibody
       clones M14, M18, and M19

<400>  1

Gly Asp Ser Ile Thr Ser Gly Tyr Trp 
1               5                   


<210>  2
<211>  16
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  Variable heavy chain CDR-H2 amino acid sequence of mouse antibody
       clones M14 and M19

<400>  2

Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  12
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Variable heavy chain CDR-H3 amino acid sequence of mouse antibody
       clones M14, M18, and M19

<400>  3

Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  4
<211>  25
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  Variable region heavy chain framework HC-FR1 amino acid sequence 
       of mouse antibody clone M14

<400>  4

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr 
            20                  25  


<210>  5
<211>  15
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Variable region heavy chain framework HC-FR2 amino acid sequence 
       of mouse antibody clone M14

<400>  5

Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met Gly 
1               5                   10                  15  


<210>  6
<211>  30
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Variable region heavy chain framework HC-FR3 amino acid sequence 
       of mouse antibody clone M14

<400>  6

Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Gln 
1               5                   10                  15      


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  7
<211>  11
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  Variable region heavy chain framework HC-FR4 amino acid sequence 
       of mouse antibody clone M14

<400>  7

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  15
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Variable light chain CDR-L1 amino acid sequence of mouse antibody
       clones M14 and M19

<400>  8

Arg Ala Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  9
<211>  7
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Variable light chain CDR-L2 amino acid sequence of mouse antibody
       clones M14, M18, and M19

<400>  9

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Variable light chain CDR-L3 amino acid sequence of mouse antibody
       clones M14, M18, and M19

<400>  10

Gln Gln Ser Tyr Glu Asp Pro Trp Thr 
1               5                   


<210>  11
<211>  23
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Variable region light chain framework LC-FR1 amino acid sequence 
       of mouse antibody clone M14

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  12
<211>  15
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Variable region light chain framework LC-FR2 amino acid sequence 
       of mouse antibody clone M14

<400>  12

Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  32
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Variable region light chain framework LC-FR3 amino acid sequence 
       of mouse antibody clone M14

<400>  13

Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  14
<211>  10
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Variable region light chain framework LC-FR4 amino acid sequence 
       of mouse antibody clone M14

<400>  14

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized variable heavy chain amino acid sequence of 
       mouse antibody clone M14

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized variable light chain amino acid sequence of 
       mouse antibody clone M14

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  17
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized heavy chain sequence from mouse antibody 
       clone M14 and canine IgG-A

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro Ala Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg Cys Thr Asp 
    210                 215                 220                 


Thr Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln 
        275                 280                 285             


Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
                325                 330                 335     


Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser 
            340                 345                 350         


Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile 
        355                 360                 365             


Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
    370                 375                 380                 


Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp 
385                 390                 395                 400 


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr 
            420                 425                 430         


Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445             


<210>  18
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized heavy chain sequence from mouse antibody 
       clone M14 and canine IgG-B

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  19
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized heavy chain sequence from mouse antibody 
       clone M14 and canine IgG-C

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Gln Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Ile Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Val Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Thr 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Pro Val Ala Lys Glu Cys Glu Cys Lys Cys 
    210                 215                 220                 


Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Val Thr Ala 
                245                 250                 255     


Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asn 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys Gln Val Gln Thr 
        275                 280                 285             


Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Ser Gly Lys Gln 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Glu 
                325                 330                 335     


Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln Pro Asn Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn Thr Val Thr Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Met Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Ile Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  20
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized heavy chain sequence from mouse antibody 
       clone M14 and canine IgG-D

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Thr Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His Pro Ala Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Pro Val Pro Lys Glu Ser Thr Cys Lys Cys 
    210                 215                 220                 


Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro 
                245                 250                 255     


Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr 
        275                 280                 285             


Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
            340                 345                 350         


Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu 
        355                 360                 365             


Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu 
385                 390                 395                 400 


Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu 
            420                 425                 430         


Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  21
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Caninized light chain sequence from mouse antibody 
       clone M14 and canine light chain constant region

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220     


<210>  22
<211>  159
<212>  PRT
<213>  Canidae sp.


<220>
<221>  misc_feature
<222>  (1)..(159)
<223>  Canine IL31 amino acid sequence

<400>  22

Met Leu Ser His Thr Gly Pro Ser Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Ser Met Glu Thr Leu Leu Ser Ser His Met Ala Pro Thr His Gln Leu 
            20                  25                  30          


Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  23
<211>  17
<212>  PRT
<213>  Canidae sp.


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Canine IL31 epitope

<400>  23

Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  111
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(111)
<223>  Variable light chain amino acid sequence of mouse antibody clone 
       M14

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  118
<212>  PRT
<213>  Murinae sp.


<220>
<221>  misc_feature
<222>  (1)..(118)
<223>  Variable heavy chain amino acid sequence of mouse antibody clone 
       M14

<400>  25

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  26
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric variable light chain of mouse antibody clone 
       M14 and canine light chain constant region

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220     


<210>  27
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric variable heavy chain of mouse antibody clone 
       M14 and canine IgG-B

<400>  27

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  28
<211>  159
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(159)
<223>  Feline IL31 amino acid sequence NCBI ref: XP_011286140.1 [felis 
       catus]

<400>  28

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Ala His Arg Leu 
            20                  25                  30          


Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 
        35                  40                  45              


Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Ile Gly Leu Pro Glu 
    50                  55                  60                  


Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 
65                  70                  75                  80  


His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys Val Ser Met Pro Ala Asp 
        115                 120                 125             


Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  29
<211>  209
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(209)
<223>  Equine IL31 amino acid sequence

<400>  29

Met Val Ser His Ile Gly Ser Thr Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Thr Leu Met Phe Ser His Thr Gly Pro Ile Tyr Gln Leu 
            20                  25                  30          


Gln Pro Lys Glu Ile Gln Ala Ile Ile Val Glu Leu Gln Asn Leu Ser 
        35                  40                  45              


Lys Lys Leu Leu Asp Asp Tyr Leu Asn Lys Glu Lys Gly Val Gln Lys 
    50                  55                  60                  


Phe Asp Ser Asp Leu Pro Ser Cys Phe Thr Ser Asp Ser Gln Ala Pro 
65                  70                  75                  80  


Gly Asn Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Lys Ala Ile Ser 
                85                  90                  95      


Pro Ser Leu Asn Asn Asp Lys Ser Leu Tyr Ile Ile Glu Gln Leu Asp 
            100                 105                 110         


Lys Leu Asn Phe Gln Asn Ala Pro Glu Thr Glu Val Ser Met Pro Thr 
        115                 120                 125             


Asp Asn Phe Glu Arg Lys Arg Phe Ile Leu Thr Ile Leu Arg Trp Phe 
    130                 135                 140                 


Ser Asn Cys Leu Glu Leu Ala Met Lys Thr Leu Thr Thr Ala Glu Gln 
145                 150                 155                 160 


Ala Leu Pro Pro Leu Asp Pro Ser Thr Pro His Ala Gly Ala Val Ala 
                165                 170                 175     


Leu Thr His His Gln Gln Asp Arg Thr Ala Leu Asp Arg Ala Val Phe 
            180                 185                 190         


Pro Phe Val Trp Ala Ala Pro Arg Gly Gly Glu Val Gly Asp Gly Gly 
        195                 200                 205             


His 
    


<210>  30
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric variable light chain of mouse antibody clone 
       M14 and feline light chain constant region

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 
    130                 135                 140                 


Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn 
145                 150                 155                 160 


Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser 
            180                 185                 190         


His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 
        195                 200                 205             


Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215                 220     


<210>  31
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Chimeric variable heavy chain of mouse antibody clone 
       M14 and feline heavy chain constant region

<400>  31

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Pro Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly 
    210                 215                 220                 


Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro 
            260                 265                 270         


Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val 
        275                 280                 285             


Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser 
        355                 360                 365             


Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser 
            420                 425                 430         


Val Ser His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr 
        435                 440                 445             


Gln Ser Pro Gly Lys 
    450             


<210>  32
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized variable light chain sequence from mouse 
       antibody clone M14

<400>  32

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized variable heavy chain sequence from mouse 
       antibody clone M14

<400>  33

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  34
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized light chain sequence from mouse antibody 
       clone M14

<400>  34

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 
    130                 135                 140                 


Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Asn 
145                 150                 155                 160 


Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln Ser 
            180                 185                 190         


His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 
        195                 200                 205             


Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215                 220     


<210>  35
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Felinized heavy chain sequence from mouse antibody 
       clone M14

<400>  35

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala His Pro Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp His Pro Pro Gly 
    210                 215                 220                 


Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val Asp Leu Gly Pro 
            260                 265                 270         


Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp Asn Thr Gln Val 
        275                 280                 285             


Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg Asn Lys Val Ser 
        355                 360                 365             


Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser 
            420                 425                 430         


Val Ser His Glu Ala Leu His Ser His His Thr Gln Lys Ser Leu Thr 
        435                 440                 445             


Gln Ser Pro Gly Lys 
    450             


<210>  36
<211>  238
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(238)
<223>  Light chain amino acid sequence of mouse antibody clone M14

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  37
<211>  238
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(238)
<223>  Light chain amino acid sequence of mouse antibody clone M18

<400>  37

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Thr Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  38
<211>  238
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(238)
<223>  Light chain amino acid sequence of mouse antibody clone M19

<400>  38

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Ile Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  39
<211>  238
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(238)
<223>  Light chain amino acid sequence of mouse antibody clone M87

<400>  39

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 
        35                  40                  45              


Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ile Arg Glu Leu Thr Arg Ser Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  40
<211>  152
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(152)
<223>  Variable and hinge heavy chain amino acid sequence of mouse 
       antibody clone M14

<400>  40

Met Ala Val Leu Gly Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser 
145                 150         


<210>  41
<211>  152
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(152)
<223>  Variable and hinge heavy chain amino acid sequence of mouse 
       antibody clone M18

<400>  41

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser 
145                 150         


<210>  42
<211>  152
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(152)
<223>  Variable and hinge heavy chain amino acid sequence of mouse 
       antibody clone M19

<400>  42

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Glu Leu 
    50                  55                  60                  


Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser 
145                 150         


<210>  43
<211>  154
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(154)
<223>  Variable and hinge heavy chain amino acid sequence of mouse 
       antibody clone M87

<400>  43

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Cys Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser 
145                 150                 


<210>  44
<211>  137
<212>  PRT
<213>  Canidae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(137)
<223>  Mature canine IL31 amino acid sequence

<400>  44

Ser Ser His Met Ala Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg 
1               5                   10                  15      


Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp 
            20                  25                  30          


Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu 
        35                  40                  45              


Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala 
    50                  55                  60                  


Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile 
65                  70                  75                  80  


Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu 
                85                  90                  95      


Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser 
            100                 105                 110         


Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val 
        115                 120                 125             


Phe Lys Ser Leu Asn Ser Gly Pro Gln 
    130                 135         


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL31 epitope


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is any amino acid; or wherein X is a hydrophobic amino acid, or
       wherein X is selected from A, V, I, and L, or wherein X is 
       selected from V and I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is any amino acid; or wherein X is a hydrophilic amino acid, or
       wherein X is selected from A, R, K, Q, and N; or wherein X is 
       selected from R and Q

<400>  45

Pro Ser Asp Xaa Xaa Lys Ile 
1               5           


<210>  46
<211>  164
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(164)
<223>  Human IL31 precursor amino acid sequence NCBI ref: NP_001014358.1

<400>  46

Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 
            20                  25                  30          


Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 
        35                  40                  45              


Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 
    50                  55                  60                  


Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 
65                  70                  75                  80  


Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 
                85                  90                  95      


Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 
            100                 105                 110         


Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 
        115                 120                 125             


Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 
    130                 135                 140                 


Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 
145                 150                 155                 160 


Gln Ala Thr Thr 
                


<210>  47
<211>  177
<212>  PRT
<213>  Odobenus rosmarus divergens


<220>
<221>  MISC_FEATURE
<222>  (1)..(177)
<223>  Predicted walrus IL31 amino acid sequence NCBI ref: 
       XP_004395998.1 [odobeus rosmarus divergens]

<400>  47

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Phe Met Gly Thr Ser Leu Thr Ser Gln Thr Ala Pro Ile His Gln Leu 
            20                  25                  30          


His Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Thr Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Ser Lys Ser Phe Ile Leu Ala Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Asp His Val Phe Lys Ser Leu Asn Pro Gly Pro Gln Gln 
145                 150                 155                 160 


Val Met Gln Gly His Leu Ile Glu Pro Ile Pro Ser Gly Thr Ala Asp 
                165                 170                 175     


Val 
    


<210>  48
<211>  187
<212>  PRT
<213>  Odobenus rosmarus divergens


<220>
<221>  MISC_FEATURE
<222>  (1)..(187)
<223>  Walrus_IL31_His6

<400>  48

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Phe Met Gly Thr Ser Leu Thr Ser Gln Thr Ala Pro Ile His Gln Leu 
            20                  25                  30          


His Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Thr Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Ser Lys Ser Phe Ile Leu Ala Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Asp His Val Phe Lys Ser Leu Asn Pro Gly Pro Gln Gln 
145                 150                 155                 160 


Val Met Gln Gly His Leu Ile Glu Pro Ile Pro Ser Gly Thr Ala Asp 
                165                 170                 175     


Val Gly Ser Gly Ser His His His His His His 
            180                 185         


<210>  49
<211>  163
<212>  PRT
<213>  Papio anubis


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted olive baboon IL31 amino acid sequence NCBI ref: 
       XP_003907358.1 [papio anubis]

<400>  49

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Glu 
                85                  90                  95      


Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  50
<211>  173
<212>  PRT
<213>  Papio anubis


<220>
<221>  MISC_FEATURE
<222>  (1)..(173)
<223>  Olive baboon_IL31_His6

<400>  50

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Glu 
                85                  90                  95      


Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr Gly Ser Gly Ser His His His His His His 
                165                 170             


<210>  51
<211>  159
<212>  PRT
<213>  Ursus maritimus


<220>
<221>  MISC_FEATURE
<222>  (1)..(159)
<223>  Predicted polar bear IL31 amino acid sequence NCBI ref: 
       XP_008687166.1 [ursus maritimus]

<400>  51

Met Leu Ser Arg Ala Val Pro Ala Gly Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Tyr Met Glu Thr Leu Leu Thr Ser His Thr Ala Pro Thr His Arg Leu 
            20                  25                  30          


Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Thr Gly Leu Pro Glu 
    50                  55                  60                  


Ser Asn His Ser Leu Val Pro Cys Leu Thr Ser Asp Ser Glu Ala Pro 
65                  70                  75                  80  


His Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Val Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Gly Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu Arg Val Phe Lys Ser Leu Asn Pro Gly Ala Gln 
145                 150                 155                 


<210>  52
<211>  185
<212>  PRT
<213>  Ursus maritimus


<220>
<221>  MISC_FEATURE
<222>  (1)..(185)
<223>  Predicted weddell seal IL31 amino acid sequence NCBI ref: 
       XP_006746595.1 [leptonychotes weddellii]

<400>  52

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Phe Met Glu Thr Ser Leu Thr Ser Gln Thr Val Pro Ile His Gln Leu 
            20                  25                  30          


Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Lys Gly Leu Leu Glu Asp Tyr Leu Lys Lys Glu Met Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn His Phe Leu Leu Pro Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Ile Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Ile Ile Asn Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Val Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Ser Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Gly His Val Leu Lys Ser Leu Asn Pro Gly Pro Gln Gln 
145                 150                 155                 160 


Val Met Gln Gly His Leu Ala Lys Pro Ile Pro Ser Gly Thr Ala Asp 
                165                 170                 175     


Met Tyr Glu Thr Leu Arg His His His 
            180                 185 


<210>  53
<211>  159
<212>  PRT
<213>  Panthera tigris altaica


<220>
<221>  MISC_FEATURE
<222>  (1)..(159)
<223>  Predicted amur tiger IL31 amino acid sequence NCBI ref: 
       XP_007079636.1 [panther tigris altaica]

<400>  53

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Thr His Arg Leu 
            20                  25                  30          


Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 
        35                  40                  45              


Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Met Gly Leu Pro Glu 
    50                  55                  60                  


Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 
65                  70                  75                  80  


His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln Arg Glu Pro Glu Ala Glu Val Ser Met Pro Ala Asp 
        115                 120                 125             


Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  54
<211>  159
<212>  PRT
<213>  Acinonyx jubatus


<220>
<221>  MISC_FEATURE
<222>  (1)..(159)
<223>  Predicted cheetah IL31 amino acid sequence NCBI ref: 
       XP_014919275.1 [acinonyx jubatus]

<400>  54

Met Leu Ser His Ala Gly Pro Ala Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Met Glu Thr Leu Leu Pro Ser His Met Ala Pro Thr His Arg Leu 
            20                  25                  30          


Gln Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Arg Pro Met Ser 
        35                  40                  45              


Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu Met Gly Leu Pro Glu 
    50                  55                  60                  


Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser Asp Ser Gln Leu Pro 
65                  70                  75                  80  


His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln Arg Glu Pro Glu Ala Glu Val Ser Met Pro Ala Asp 
        115                 120                 125             


Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn Ser Gly Ser Gln 
145                 150                 155                 


<210>  55
<211>  163
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted crab-eating macaque IL31 amino acid sequence GenBank 
       ref: EHH66805.1 [macaca fascicularis]

<400>  55

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 
                85                  90                  95      


Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  56
<211>  158
<212>  PRT
<213>  Macaca mulatta


<220>
<221>  MISC_FEATURE
<222>  (1)..(158)
<223>  Predicted rhesus monkey IL31 amino acid sequence (partial) 
       GenBank ref: EHH21279.1 [macaca mulatta]

<400>  56

Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys Cys Leu Gly Gly Trp 
1               5                   10                  15      


Leu Thr Ser His Thr Leu Pro Val His Phe Leu Gln Pro Ser Asp Ile 
            20                  25                  30          


Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser Lys Met Leu Leu Lys 
        35                  40                  45              


Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser Gln Asn Tyr Thr Leu 
    50                  55                  60                  


Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn Ile Ile His Ser Pro 
65                  70                  75                  80  


Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser 
                85                  90                  95      


Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp 
            100                 105                 110         


Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys 
        115                 120                 125             


Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Cys Met Asp Leu 
    130                 135                 140                 


Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln Ala Thr Thr 
145                 150                 155             


<210>  57
<211>  163
<212>  PRT
<213>  Mandrillus leucophaeus


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted drill IL31 amino acid sequence NCBI ref: XP_011819882.1
       [mandrillus leucophaeus]

<400>  57

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Lys Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 
                85                  90                  95      


Leu Asp Asn Arg Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  58
<211>  163
<212>  PRT
<213>  Chlorocebus sabaeus


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted green monkey IL31 amino acid sequence NCBI ref: 
       XP_008003211.1 [chlorocebus sabaeus]

<400>  58

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Lys Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 
                85                  90                  95      


Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  59
<211>  163
<212>  PRT
<213>  Cercocebus atys


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted sooty mangebey IL31 amino acid sequence NCBI ref: 
       XP_011926625.1 [cercocebus atys]

<400>  59

Met Ala Ser His Ser Gly Pro Ala Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Gln Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Lys Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 
                85                  90                  95      


Leu Asp Asn Arg Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  60
<211>  163
<212>  PRT
<213>  Rhinopithecus roxellana


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Predicted golden snub-nosed monkey IL31 amino acid sequence NCBI 
       ref: XP_010366647.1 [rhinopithecus roxellana]

<400>  60

Met Ala Ser His Ser Gly Pro Thr Thr Ser Val Leu Phe Leu Leu Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Thr Ser His Thr Leu Pro Val His Phe Leu 
            20                  25                  30          


Arg Pro Ser Asp Ile Gln Lys Ile Val Glu Glu Leu Gln Ser Leu Ser 
        35                  40                  45              


Lys Met Leu Leu Lys Asp Val Glu Glu Asp Lys Gly Val Leu Val Ser 
    50                  55                  60                  


Gln Asn Tyr Thr Leu Pro Cys Leu Thr Pro Asp Ala Gln Pro Pro Asn 
65                  70                  75                  80  


Ile Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln 
                85                  90                  95      


Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
            100                 105                 110         


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
        115                 120                 125             


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
    130                 135                 140                 


Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln Gln 
145                 150                 155                 160 


Ala Thr Thr 
            


<210>  61
<211>  163
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(163)
<223>  Murine IL31 precursor amino acid sequence NCBI ref: NP_083870 
       [mus musculus]

<400>  61

Met Ile Phe His Thr Gly Thr Thr Lys Pro Thr Leu Val Leu Leu Cys 
1               5                   10                  15      


Cys Ile Gly Thr Trp Leu Ala Thr Cys Ser Leu Ser Phe Gly Ala Pro 
            20                  25                  30          


Ile Ser Lys Glu Asp Leu Arg Thr Thr Ile Asp Leu Leu Lys Gln Glu 
        35                  40                  45              


Ser Gln Asp Leu Tyr Asn Asn Tyr Ser Ile Lys Gln Ala Ser Gly Met 
    50                  55                  60                  


Ser Ala Asp Glu Ser Ile Gln Leu Pro Cys Phe Ser Leu Asp Arg Glu 
65                  70                  75                  80  


Ala Leu Thr Asn Ile Ser Val Ile Ile Ala His Leu Glu Lys Val Lys 
                85                  90                  95      


Val Leu Ser Glu Asn Thr Val Asp Thr Ser Trp Val Ile Arg Trp Leu 
            100                 105                 110         


Thr Asn Ile Ser Cys Phe Asn Pro Leu Asn Leu Asn Ile Ser Val Pro 
        115                 120                 125             


Gly Asn Thr Asp Glu Ser Tyr Asp Cys Lys Val Phe Val Leu Thr Val 
    130                 135                 140                 


Leu Lys Gln Phe Ser Asn Cys Met Ala Glu Leu Gln Ala Lys Asp Asn 
145                 150                 155                 160 


Thr Thr Cys 
            


<210>  62
<211>  16
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  Variable heavy chain CDR-H2 amino acid sequence of mouse antibody
       clone M18

<400>  62

Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  63
<211>  15
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Variable light chain CDR-L1 amino acid sequence of mouse antibody
       clone M18

<400>  63

Arg Ala Ser Glu Ser Val Asp Thr Tyr Gly Asn Ser Phe Ile His 
1               5                   10                  15  


<210>  64
<211>  131
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Variable light chain amino acid sequence of mouse antibody clone 
       M18

<400>  64

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Thr Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  65
<211>  131
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Variable light chain amino acid sequence of mouse antibody clone 
       M19

<400>  65

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Thr Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Ile Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Tyr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  66
<211>  131
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Variable light chain amino acid sequence of mouse antibody clone 
       M87

<400>  66

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser 
        35                  40                  45              


Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ile Arg Glu Leu Thr Arg Ser Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  67
<211>  137
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(137)
<223>  Variable heavy chain amino acid sequence of mouse antibody clone 
       M18

<400>  67

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135         


<210>  68
<211>  137
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(137)
<223>  Variable heavy chain amino acid sequence of mouse antibody clone 
       M19

<400>  68

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Glu Leu 
    50                  55                  60                  


Glu Tyr Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135         


<210>  69
<211>  139
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(139)
<223>  Variable heavy chain amino acid sequence of mouse antibody clone 
       M87

<400>  69

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Cys Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 


<210>  70
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 HC-FR1

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr 
            20                  25  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 HC-FR2

<400>  71

Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met Gly 
1               5                   10                  15  


<210>  72
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 HC-FR3

<400>  72

Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu Gln 
1               5                   10                  15      


Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  73
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternate caninized M14 HC-FR3

<400>  73

Asn Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys 
1               5                   10                  15      


Asn Gln Tyr Tyr Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 HC-FR4

<400>  74

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  75
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 LC-FR1

<400>  75

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 LC-FR2

<400>  76

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  77
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 LC-FR3

<400>  77

Gly Ile Pro Ala Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asp Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized M14 LC-FR4

<400>  78

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  79
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 HC-FR1

<400>  79

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr 
            20                  25  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 HC-FR2

<400>  80

Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val Ala 
1               5                   10                  15  


<210>  81
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 HC-FR3

<400>  81

Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
1               5                   10                  15      


Asn Thr Leu Tyr Leu Gln Leu Asn Asn Leu Lys Ala Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Tyr Cys Ala 
        35          


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 HC-FR4

<400>  82

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 LC-FR1

<400>  83

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 LC-FR2

<400>  84

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  85
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 LC-FR3

<400>  85

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Felinized M14 LC-FR4

<400>  86

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Alternate variable heavy chain CDR-H2 amino acid sequence of 
       mouse antibody clone M18

<400>  87

Tyr Ile Ser Tyr Ser Gly Ile Thr Tyr Tyr 
1               5                   10  


<210>  88
<211>  7
<212>  PRT
<213>  Canidae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Alternative canine IL31 epitope

<400>  88

Pro Ser Asp Val Arg Lys Ile 
1               5           


<210>  89
<211>  10
<212>  PRT
<213>  Murinae sp.


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Alternate variable heavy chain CDR-H2 amino acid sequence of 
       mouse antibody clones M14 and M19

<400>  89

Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr 
1               5                   10  


