                         SEQUENCE LISTING

<110>  Ding, Enyu
 
<120>  An mRNA cancer vaccine encoding human GM-CSF fused to multiple 
       tandem epitopes

<130>  SequenceListing2

<150>  US 62/348,895
<151>  2016-06-11

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  59
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Primer
<222>  (1)..(59)

<400>  1
acgtgctagc gccgccacca tggggctgca gagcctgctg ctcttgggca ctgtggcct        59


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  3
<211>  75
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Primer
<222>  (1)..(75)

<400>  3
acgtaagctt cccgcctcca ccactacctc ccccgccctc ctggactggc tcccagcagt       60

caaaggggat gacaa                                                        75


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Leu Ala Lys Phe Leu His Trp Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Leu Phe Phe Tyr Arg Lys Ser Val 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Leu Gln Val Asn Ser Leu Gln Thr Val 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10      


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Ile Leu Ala Lys Phe Leu His Trp Leu Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Tyr Leu Phe Phe Tyr Arg Lys Ser Val Gly Gly Tyr 
            20                  25                  30          


Leu Gln Val Asn Ser Leu Gln Thr Val 
        35                  40      


<210>  9
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9
atgatcctgg ccaagttcct gcactggctg ggtggcggag ggtctggtgg cggagggtct       60

ggttatctct ttttctaccg gaagagtgtc ggtggctatt tgcaggtgaa cagcctccag      120

acggtg                                                                 126


<210>  10
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10
gatccatgat cctggccaag ttcctgcact ggctgggtgg c                           41


<210>  11
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11
ggagggtctg gtggcggagg gtctggttat ctctttttct accgg                       45


<210>  12
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12
aagagtgtcg gtggctattt gcaggtgaac agcctccaga cggtg                       45


<210>  13
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13
tcgaccaccg tctggaggct gttcacctgc aaatagccac c                           41


<210>  14
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14
gacactcttc cggtagaaaa agagataacc agaccctccg ccacc                       45


<210>  15
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15
agaccctccg ccacccagcc agtgcaggaa cttggccagg atcatg                      46


<210>  16
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(40)

<400>  16
acgtaagctt atcctggcca agttcctgca ctggctgggt                             40


<210>  17
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(46)

<400>  17
acgtctcgag tcacaccgtc tggaggctgt tcacctgcaa atagcc                      46


<210>  18
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18
atcctggcca agttcctgca ctggctgggt ggcggagggt ctggtggcgg agggtctggt       60

tatctctttt tctaccggaa gagtgtcggt ggctatttgc aggtgaacag cctccagacg      120

gtg                                                                    123


<210>  19
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19
atggggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agggcggggg aggtagtggt ggaggcggga agcttatcct ggccaagttc      480

ctgcactggc tgggtggcgg agggtctggt ggcggagggt ctggttatct ctttttctac      540

cggaagagtg tcggtggcta tttgcaggtg aacagcctcc agacggtgtg a               591


<210>  20
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Met Gly Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Lys Leu Ile Leu Ala Lys Phe 
145                 150                 155                 160 


Leu His Trp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Tyr 
                165                 170                 175     


Leu Phe Phe Tyr Arg Lys Ser Val Gly Gly Tyr Leu Gln Val Asn Ser 
            180                 185                 190         


Leu Gln Thr Val 
        195     


<210>  21
<211>  3930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag attggaccct cgtacagaag      720

ctaatacgac tcactatagg gaaataagag agaaaagaag agtaagaaga aatataagag      780

ccaccgctag cgccgccacc atggggctgc agagcctgct gctcttgggc actgtggcct      840

gcagcatctc tgcacccgcc cgctcgccca gccccagcac gcagccctgg gagcatgtga      900

atgccatcca ggaggcccgg cgtctcctga acctgagtag agacactgct gctgagatga      960

atgaaacagt agaagtcatc tcagaaatgt ttgacctcca ggagccgacc tgcctacaga     1020

cccgcctgga gctgtacaag cagggcctgc ggggcagcct caccaagctc aagggcccct     1080

tgaccatgat ggccagccac tacaagcagc actgccctcc aaccccggaa acttcctgtg     1140

caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt ctgcttgtca     1200

tcccctttga ctgctgggag ccagtccagg agggcggggg aggtagtggt ggaggcggga     1260

agcttatcct ggccaagttc ctgcactggc tgggtggcgg agggtctggt ggcggagggt     1320

ctggttatct ctttttctac cggaagagtg tcggtggcta tttgcaggtg aacagcctcc     1380

agacggtgtg actcgagtct agagggcccg tttaaacacc ggtagctcgc ttgtccaatt     1440

tctattaaag gttcctttgt tccctaagtc caactactaa actgggggat attatgaagg     1500

gccttgagca tctggattct gcctaataaa aaacatttat tttcattgca tcgatagctc     1560

gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc aactactaaa     1620

ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa aacatttatt     1680

ttcattgccc gcggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaattatta ctagtccgct gatcagcctc gactgtgcct tctagttgcc     1860

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     1920

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     1980

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     2040

atgctgggga tgcggtgggc tctatggctt ctttaattaa actgggcggt tttatggaca     2100

gcaagcgaac cggaattgcc agctggggcg ccctctggta aggttgggaa gccctgcaaa     2160

gtaaactgga tggctttctc gccgccaagg atctgatggc gcaggggatc aagctctgat     2220

caagagacag gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct     2280

ccggccgctt gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc     2340

tctgatgccg ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc     2400

gacctgtccg gtgccctgaa tgaactgcaa gacgaggcag cgcggctatc gtggctggcc     2460

acgacgggcg ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg     2520

ctgctattgg gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag     2580

aaagtatcca tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc     2640

ccattcgacc accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt     2700

cttgtcgatc aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc     2760

gccaggctca aggcgagcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc     2820

tgcttgccga atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg     2880

ctgggtgtgg cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag     2940

cttggcggcg aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg     3000

cagcgcatcg ccttctatcg ccttcttgac gagttcttct gaattattaa cgcttacaat     3060

ttcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacaggtg     3120

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     3180

atatgtatcc gcttaattaa tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     3240

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     3300

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     3360

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     3420

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     3480

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     3540

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     3600

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     3660

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     3720

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     3780

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     3840

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggg     3900

cttttgctgg ccttttgctc acatgttctt                                      3930


<210>  22
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
1               5                   10                  15      


Pro Ala Pro Gly Ser Thr Ala Pro Pro 
            20                  25  


<210>  23
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  23
tccaccgccc ccccagccca cggtgtcacc tcggccccgg acaccaggcc ggccccgggc       60

tccaccgccc cccca                                                        75


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10              


<210>  25
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  25
aagctggtgg tggtgggcgc cgtgggtgtg ggcaagagt                              39


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Ile Met Gln Leu Met Pro Phe Gly Cys Leu 
1               5                   10      


<210>  27
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  27
ctcatcatgc agctcatgcc cttcggctgc ctc                                    33


<210>  28
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
1               5                   10                  15      


Pro Ala Pro Gly Ser Thr Ala Pro Pro Gly Gly Lys Leu Val Val Val 
            20                  25                  30          


Gly Ala Val Gly Val Gly Lys Ser Gly Gly Leu Ile Met Gln Leu Met 
        35                  40                  45              


Pro Phe Gly Cys Leu 
    50              


<210>  29
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29
tccaccgccc ccccagccca cggtgtcacc tcggccccgg acaccaggcc ggccccgggc       60

tccaccgccc ccccaggagg taagctggtg gtggtgggcg ccgtgggtgt gggcaagagt      120

ggaggtctca tcatgcagct catgcccttc ggctgcctc                             159


<210>  30
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(90)

<400>  30
acgtctcgag ggtgtccggg gccgaggtga caccgtgggc tgggggggcg gtggaaagct       60

tcccgcctcc accactacct cccccgccct                                        90


<210>  31
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(79)

<400>  31
acgtctcgag tcaacctcct gggggggcgg tggagcccgg ggccggcctg gtgtccgggg       60

ccgaggtgac accgtgggc                                                    79


<210>  32
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(85)

<400>  32
acgtctcgag acctccactc ttgcccacac ccacggcgcc caccaccacc agcttacctc       60

ctgggggggc ggtggagccc ggggc                                             85


<210>  33
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  Primer
<222>  (1)..(76)

<400>  33
acgtctcgag tcagaggcag ccgaagggca tgagctgcat gatgagacct ccactcttgc       60

ccacacccac ggcgcc                                                       76


<210>  34
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34

Met Gly Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Lys Leu Ser Thr Ala Pro Pro 
145                 150                 155                 160 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                165                 170                 175     


Thr Ala Pro Pro Gly Gly Lys Leu Val Val Val Gly Ala Val Gly Val 
            180                 185                 190         


Gly Lys Ser Gly Gly Leu Ile Met Gln Leu Met Pro Phe Gly Cys Leu 
        195                 200                 205             


<210>  35
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35
atggggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agggcggggg aggtagtggt ggaggcggga agctttccac cgccccccca      480

gcccacggtg tcacctcggc cccggacacc aggccggccc cgggctccac cgccccccca      540

ggaggtaagc tggtggtggt gggcgccgtg ggtgtgggca agagtggagg tctcatcatg      600

cagctcatgc ccttcggctg cctctga                                          627


<210>  36
<211>  3966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag attggaccct cgtacagaag      720

ctaatacgac tcactatagg gaaataagag agaaaagaag agtaagaaga aatataagag      780

ccaccgctag cgccgccacc atggggctgc agagcctgct gctcttgggc actgtggcct      840

gcagcatctc tgcacccgcc cgctcgccca gccccagcac gcagccctgg gagcatgtga      900

atgccatcca ggaggcccgg cgtctcctga acctgagtag agacactgct gctgagatga      960

atgaaacagt agaagtcatc tcagaaatgt ttgacctcca ggagccgacc tgcctacaga     1020

cccgcctgga gctgtacaag cagggcctgc ggggcagcct caccaagctc aagggcccct     1080

tgaccatgat ggccagccac tacaagcagc actgccctcc aaccccggaa acttcctgtg     1140

caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt ctgcttgtca     1200

tcccctttga ctgctgggag ccagtccagg agggcggggg aggtagtggt ggaggcggga     1260

agctttccac cgccccccca gcccacggtg tcacctcggc cccggacacc aggccggccc     1320

cgggctccac cgccccccca ggaggtaagc tggtggtggt gggcgccgtg ggtgtgggca     1380

agagtggagg tctcatcatg cagctcatgc ccttcggctg cctctgactc gagtctagag     1440

ggcccgttta aacaccggta gctcgcttgt ccaatttcta ttaaaggttc ctttgttccc     1500

taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct     1560

aataaaaaac atttattttc attgcatcga tagctcgctt tcttgctgtc caatttctat     1620

taaaggttcc tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt     1680

gagcatctgg attctgccta ataaaaaaca tttattttca ttgcccgcgg aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa ttattactag     1860

tccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     1920

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     1980

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     2040

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     2100

tggcttcttt aattaaactg ggcggtttta tggacagcaa gcgaaccgga attgccagct     2160

ggggcgccct ctggtaaggt tgggaagccc tgcaaagtaa actggatggc tttctcgccg     2220

ccaaggatct gatggcgcag gggatcaagc tctgatcaag agacaggatg aggatcgttt     2280

cgcatgattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt ggagaggcta     2340

ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt gttccggctg     2400

tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc cctgaatgaa     2460

ctgcaagacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc ttgcgcagct     2520

gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga agtgccgggg     2580

caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat ggctgatgca     2640

atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca agcgaaacat     2700

cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga tgatctggac     2760

gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc gagcatgccc     2820

gacggcgagg atctcgtcgt gacccatggc gatgcctgct tgccgaatat catggtggaa     2880

aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga ccgctatcag     2940

gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg ggctgaccgc     3000

ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt ctatcgcctt     3060

cttgacgagt tcttctgaat tattaacgct tacaatttcc tgatgcggta ttttctcctt     3120

acgcatctgt gcggtatttc acaccgcata caggtggcac ttttcgggga aatgtgcgcg     3180

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctt aattaatcat     3240

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     3300

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     3360

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     3420

ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt     3480

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     3540

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     3600

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     3660

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     3720

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     3780

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     3840

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     3900

aaacgccagc aacgcggcct ttttacggtt cctgggcttt tgctggcctt ttgctcacat     3960

gttctt                                                                3966


<210>  37
<211>  5145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag attggaccct cgtacagaag      720

ctaatacgac tcactatagg gaaataagag agaaaagaag agtaagaaga aatataagag      780

ccaccgctag cgtttaaact taagcttggt accgagctcg gatcctgcag atatccagca      840

cagtggcggc cgctcgacta ctaaccttct tctctttcct acagctgaga tcaccggcga      900

aggagggcca ccatgggtca ccagcagttg gtcatctctt ggttttccct ggtttttctg      960

gcatctcccc tcgtggccat atgggaactg aagaaagatg tttatgtcgt agaattggat     1020

tggtatccgg atgcccctgg agaaatggtg gtcctcacct gtgacacccc tgaagaagat     1080

ggtatcacct ggaccttgga ccagagcagt gaggtcttag gctctggcaa aaccctgacc     1140

atccaagtca aagagtttgg agatgctggc cagtacacct gtcacaaagg aggcgaggtt     1200

ctaagccatt cgctcctgct gcttcacaaa aaggaagatg gaatttggtc cactgatatt     1260

ttaaaggacc agaaagaacc caaaaataag acctttctaa gatgcgaggc caagaattat     1320

tctggacgtt tcacctgctg gtggctgacg acaatcagta ctgatttgac attcagtgtc     1380

aaaagcagca gaggctcttc tgacccccaa ggggtgacgt gcggagctgc tacactctct     1440

gcagagagag tcagagggga caacaaggag tatgagtact cagtggagtg ccaggaggac     1500

agtgcctgcc cagctgctga ggagagtctg cccattgagg tcatggtgga tgccgttcac     1560

aagctcaagt atgaaaacta caccagcagc ttcttcatca gggacatcat caaacctgac     1620

ccacccaaga acttgcagct gaagccatta aagaattctc ggcaggtgga ggtcagctgg     1680

gagtaccctg acacctggag tactccacat tcctacttct ccctgacatt ctgcgttcag     1740

gtccagggca agagcaagag agaaaagaaa gatagagtct tcacggacaa gacctcagcc     1800

acggtcatct gccgcaaaaa tgccagcatt agcgtgcggg cccaggaccg ctactatagc     1860

tcatcttgga gcgaatgggc atctgtgccc tgcagtgttc ctggagtagg ggtacctggg     1920

gtgggcgcca gaaacctccc cgtggccact ccagacccag gaatgttccc atgccttcac     1980

cactcccaaa acctgctgag ggccgtcagc aacatgctcc agaaggccag acaaactcta     2040

gaattttacc cttgcacttc tgaagagatt gatcatgaag atatcacaaa agataaaacc     2100

agcacagtgg aggcctgttt accattggaa ttaaccaaga atgagagttg cctaaattcc     2160

agagagacct ctttcataac taatgggagt tgcctggcct ccagaaagac ctcttttatg     2220

atggccctgt gccttagtag tatttatgaa gacttgaaga tgtaccaggt ggagttcaag     2280

accatgaatg caaagctgct gatggatcct aagaggcaga tctttctaga tcaaaacatg     2340

ctggcagtta ttgatgagct gatgcaggcc ctgaatttca acagtgagac tgtgccacaa     2400

aaatcctccc ttgaagaacc ggatttttat aaaactaaaa tcaagctctg catacttctt     2460

catgctttca gaattcgggc agtgactatt gatagagtga tgagctatct gaatgcttcc     2520

taaaaagcga ggtccctcca aaccgttgtc atttttataa aactttgaaa tgaggaaact     2580

ttgataggat gtggattaag aactagggag gggctagagg gcccgtttaa acaccggtag     2640

ctcgcttgtc caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg     2700

gggatattat gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca     2760

ttgcatcgat agctcgcttt cttgctgtcc aatttctatt aaaggttcct ttgttcccta     2820

agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga ttctgcctaa     2880

taaaaaacat ttattttcat tgcccgcgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaat tattactagt ccgctgatca gcctcgactg     3060

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     3120

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     3180

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     3240

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttcttta attaaactgg     3300

gcggttttat ggacagcaag cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt     3360

gggaagccct gcaaagtaaa ctggatggct ttctcgccgc caaggatctg atggcgcagg     3420

ggatcaagct ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga     3480

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     3540

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     3600

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg     3660

ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     3720

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     3780

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     3840

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     3900

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     3960

ccagccgaac tgttcgccag gctcaaggcg agcatgcccg acggcgagga tctcgtcgtg     4020

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     4080

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     4140

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     4200

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgaatt     4260

attaacgctt acaatttcct gatgcggtat tttctcctta cgcatctgtg cggtatttca     4320

caccgcatac aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     4380

tctaaataca ttcaaatatg tatccgctta attaatcatg accaaaatcc cttaacgtga     4440

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     4500

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     4560

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     4620

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     4680

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     4740

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     4800

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     4860

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     4920

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     4980

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     5040

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     5100

tttacggttc ctgggctttt gctggccttt tgctcacatg ttctt                     5145


