                         SEQUENCE LISTING

<110>  St George's Hospital Medical School
 
<120>  BIOMARKERS

<130>  N410019WO

<150>  GB 1703123.8
<151>  2017-02-27

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Glu Arg His Ala Ala Glu Val Arg Arg Asn Lys Glu Leu Gln Val Glu 
                165                 170                 175     


Leu Ser Gly 
            


<210>  2
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Leu Val Lys Phe Ile Ser Ser Glu Leu Lys Glu Ser Ile Glu Ser Gln 
                165                 170                 175     


Phe Leu Glu Leu Gln Arg Glu Gly Glu Lys Gln 
            180                 185         


<210>  3
<211>  2232
<212>  DNA
<213>  Homo sapiens

<400>  3
agctcctagg aagcttcagg gcttaaagct ccactctact tggactgtac tatcaggccc       60

ccaaaatggg gggagccgac agggaaggac tgatttccat ttcaaactgc attctggtac      120

tttgtactcc agcaccattg gccgatcaat atttaatgct tggagattct gactctgcgg      180

gagtcatgtc aggggacctt gggagccaat ctgcttgagc ttctgagtga taattattca      240

tgggctcctg cctcttgctc tttctctagc acggtcccac tctgcagact cagtgcctta      300

ttcagtcttc tctctcgctc tctccgctgc tgtagccgga ccctttgcct tcgccactgc      360

tcagcgtctg cacatcccta caatggctaa aacagcaatg gcctacaagg aaaaaatgaa      420

ggagctgtcc atgctgtcac tgatctgctc ttgcttttac ccggaacctc gcaacatcaa      480

catctatact tacgatgata tggaagtgaa gcaaatcaac aaacgtgcct ctggccaggc      540

ttttgagctg atcttgaagc caccatctcc tatctcagaa gccccacgaa ctttagcttc      600

tccaaagaag aaagacctgt ccctggagga gatccagaag aaactggagg ctgcagagga      660

aagaagaaag tctcaggagg cccaggtgct gaaacaattg gcagagaaga gggaacacga      720

gcgagaagtc cttcagaagg ctttggagga gaacaacaac ttcagcaaga tggcggagga      780

aaagctgatc ctgaaaatgg aacaaattaa ggaaaaccgt gaggctaatc tagctgctat      840

tattgaacgt ctgcaggaaa aggagaggca tgctgcggag gtgcgcagga acaaggaact      900

ccaggttgaa ctgtctggct gaagcaaggg agggtctggc acgccccacc aatagtaaat      960

ccccctgcct atattataat ggatcatgcg atatcaggat ggggaatgta tgacatggtt     1020

taaaaagaac tcattataaa aaaaaaaaaa caaaaaaaat caaaaattaa aaaaaatcaa     1080

tgcggtctct ttgcagaatg ttttgcttga tgtttaaaaa ataccttgga tcttattttg     1140

taaatactta catttttgtt aaaaaataca agtattgcat tatgcaagtt atttcataat     1200

cttacatgtc ctgtaacagg cttttgatgt tgtgtctttc cactcaaatg aatttgctag     1260

gtctgttctt tttgaagctc cccatgtcta actccattcc aaaagaaaaa tgaggtcagt     1320

agacagtcta tggtgctaga aacccaccat tgcctaatga cctagaaggc tttgttgtct     1380

ctgagcttga ctaagaccat acctagatca caggtattat gactccacat gaaccttcac     1440

atttgttcgc tcataatcta cttactgcct aaaaactaca aaaccaggct aagaaatacc     1500

accagtcata gcatttactt ctgcttctcc tggattatgt gctacaaatg tgctttggct     1560

ttagaaaggg atggatgaga agacagacct gagaccaatc tgggtagaag caaaaagttg     1620

aaccttttaa agtgctgaac acaaatccaa attcgaatgg ttcaagcagc cgtgaaatcg     1680

ctcttcataa agtgggctta attctctagt ttaagttctt ttgatggaat gaattaatta     1740

atgtgtcagg tggcttattt gtggatgcca tgattgatga tgttcatttt aagctcttac     1800

ctatagtaca agtacatgat gctactgaat atttttccac ttggaaactg tgagctggtt     1860

gttgcattaa aacacacata caaacaaaat caaaaacact gcggactttc actcaagctg     1920

gtctttcttc cccagtgtaa ggcaatcctg cctactaaca acaccaacaa caaaacactc     1980

catctgtgaa gctgacgcag ttaagggggc taggcagggc atttgtgcca actaagaatc     2040

accagatacc caccataagt acctatcgca gttttgaagt cgtttctccc caactcccaa     2100

ctcctgaagg ttgctgcctg catatttact cttcattagt gctattttcc tgtatgtcat     2160

tgtgagcaag ctgtgattaa taaagaattg gagttctgtg aactaataaa ggtttggtct     2220

gttaaaaaaa aa                                                         2232


<210>  4
<211>  2314
<212>  DNA
<213>  Homo sapiens

<400>  4
agctcctagg aagcttcagg gcttaaagct ccactctact tggactgtac tatcaggccc       60

ccaaaatggg gggagccgac agggaaggac tgatttccat ttcaaactgc attctggtac      120

tttgtactcc agcaccattg gccgatcaat atttaatgct tggagattct gactctgcgg      180

gagtcatgtc aggggacctt gggagccaat ctgcttgagc ttctgagtga taattattca      240

tgggctcctg cctcttgctc tttctctagc acggtcccac tctgcagact cagtgcctta      300

ttcagtcttc tctctcgctc tctccgctgc tgtagccgga ccctttgcct tcgccactgc      360

tcagcgtctg cacatcccta caatggctaa aacagcaatg gcctacaagg aaaaaatgaa      420

ggagctgtcc atgctgtcac tgatctgctc ttgcttttac ccggaacctc gcaacatcaa      480

catctatact tacgatgata tggaagtgaa gcaaatcaac aaacgtgcct ctggccaggc      540

ttttgagctg atcttgaagc caccatctcc tatctcagaa gccccacgaa ctttagcttc      600

tccaaagaag aaagacctgt ccctggagga gatccagaag aaactggagg ctgcagagga      660

aagaagaaag tctcaggagg cccaggtgct gaaacaattg gcagagaaga gggaacacga      720

gcgagaagtc cttcagaagg ctttggagga gaacaacaac ttcagcaaga tggcggagga      780

aaagctgatc ctgaaaatgg aacaaattaa ggaaaaccgt gaggctaatc tagctgctat      840

tattgaacgt ctgcaggaaa agctggtcaa gtttatttct tctgaactaa aagaatctat      900

agagtctcaa tttctggagc ttcagaggga aggagagaag caatgagagg catgctgcgg      960

aggtgcgcag gaacaaggaa ctccaggttg aactgtctgg ctgaagcaag ggagggtctg     1020

gcacgcccca ccaatagtaa atccccctgc ctatattata atggatcatg cgatatcagg     1080

atggggaatg tatgacatgg tttaaaaaga actcattata aaaaaaaaaa aacaaaaaaa     1140

atcaaaaatt aaaaaaaatc aatgcggtct ctttgcagaa tgttttgctt gatgtttaaa     1200

aaataccttg gatcttattt tgtaaatact tacatttttg ttaaaaaata caagtattgc     1260

attatgcaag ttatttcata atcttacatg tcctgtaaca ggcttttgat gttgtgtctt     1320

tccactcaaa tgaatttgct aggtctgttc tttttgaagc tccccatgtc taactccatt     1380

ccaaaagaaa aatgaggtca gtagacagtc tatggtgcta gaaacccacc attgcctaat     1440

gacctagaag gctttgttgt ctctgagctt gactaagacc atacctagat cacaggtatt     1500

atgactccac atgaaccttc acatttgttc gctcataatc tacttactgc ctaaaaacta     1560

caaaaccagg ctaagaaata ccaccagtca tagcatttac ttctgcttct cctggattat     1620

gtgctacaaa tgtgctttgg ctttagaaag ggatggatga gaagacagac ctgagaccaa     1680

tctgggtaga agcaaaaagt tgaacctttt aaagtgctga acacaaatcc aaattcgaat     1740

ggttcaagca gccgtgaaat cgctcttcat aaagtgggct taattctcta gtttaagttc     1800

ttttgatgga atgaattaat taatgtgtca ggtggcttat ttgtggatgc catgattgat     1860

gatgttcatt ttaagctctt acctatagta caagtacatg atgctactga atatttttcc     1920

acttggaaac tgtgagctgg ttgttgcatt aaaacacaca tacaaacaaa atcaaaaaca     1980

ctgcggactt tcactcaagc tggtctttct tccccagtgt aaggcaatcc tgcctactaa     2040

caacaccaac aacaaaacac tccatctgtg aagctgacgc agttaagggg gctaggcagg     2100

gcatttgtgc caactaagaa tcaccagata cccaccataa gtacctatcg cagttttgaa     2160

gtcgtttctc cccaactccc aactcctgaa ggttgctgcc tgcatattta ctcttcatta     2220

gtgctatttt cctgtatgtc attgtgagca agctgtgatt aataaagaat tggagttctg     2280

tgaactaata aaggtttggt ctgttaaaaa aaaa                                 2314


<210>  5
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctaaaa cagcaatggc ctacaaggaa aaaatgaagg agctgtccat gctgtcactg       60

atctgctctt gcttttaccc ggaacctcgc aacatcaaca tctatactta cgatgatatg      120

gaagtgaagc aaatcaacaa acgtgcctct ggccaggctt ttgagctgat cttgaagcca      180

ccatctccta tctcagaagc cccacgaact ttagcttctc caaagaagaa agacctgtcc      240

ctggaggaga tccagaagaa actggaggct gcagaggaaa gaagaaagtc tcaggaggcc      300

caggtgctga aacaattggc agagaagagg gaacacgagc gagaagtcct tcagaaggct      360

ttggaggaga acaacaactt cagcaagatg gcggaggaaa agctgatcct gaaaatggaa      420

caaattaagg aaaaccgtga ggctaatcta gctgctatta ttgaacgtct gcaggaaaag      480

gagaggcatg ctgcggaggt gcgcaggaac aaggaactcc aggttgaact gtctggttaa      540


<210>  6
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210>  7
<211>  935
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Pro Gln Val Phe Asp Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn 
1               5                   10                  15      


Pro Gly Ala Leu Leu Pro Val Leu Thr Asp Pro Ala Leu Asn Asp Leu 
            20                  25                  30          


Tyr Val Ile Ser Thr Phe Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile 
        35                  40                  45              


Phe Gly Leu Tyr Ser Ser Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr 
    50                  55                  60                  


Val Met Gly Arg Leu Asn Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp 
65                  70                  75                  80  


Gly Lys Val His Leu Val Val Phe Asn Asn Leu Gln Leu Ala Asp Gly 
                85                  90                  95      


Arg Arg His Arg Ile Leu Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala 
            100                 105                 110         


Gly Ser Leu Glu Leu Tyr Leu Asp Cys Ile Gln Val Asp Ser Val His 
        115                 120                 125             


Asn Leu Pro Arg Ala Phe Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile 
    130                 135                 140                 


Glu Leu Arg Thr Phe Gln Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu 
145                 150                 155                 160 


Lys Leu Val Val Arg Gly Ser Leu Phe Gln Val Ala Ser Leu Gln Asp 
                165                 170                 175     


Cys Phe Leu Gln Gln Ser Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp 
            180                 185                 190         


Phe Asn Arg Gln Phe Leu Gly Gln Met Thr Gln Leu Asn Gln Leu Leu 
        195                 200                 205             


Gly Glu Val Lys Asp Leu Leu Arg Gln Gln Val Lys Glu Thr Ser Phe 
    210                 215                 220                 


Leu Arg Asn Thr Ile Ala Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe 
225                 230                 235                 240 


Gln Ser Pro Thr Pro Ser Thr Val Val Pro Pro Ala Pro Pro Ala Pro 
                245                 250                 255     


Pro Thr Arg Pro Pro Arg Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly 
            260                 265                 270         


Val Gln Cys Thr Asp Ser Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro 
        275                 280                 285             


Glu Gly Tyr Thr Gly Asn Gly Ile Thr Cys Ile Asp Val Asp Glu Cys 
    290                 295                 300                 


Lys Tyr His Pro Cys Tyr Pro Gly Val His Cys Ile Asn Leu Ser Pro 
305                 310                 315                 320 


Gly Phe Arg Cys Asp Ala Cys Pro Val Gly Phe Thr Gly Pro Met Val 
                325                 330                 335     


Gln Gly Val Gly Ile Ser Phe Ala Lys Ser Asn Lys Gln Val Cys Thr 
            340                 345                 350         


Asp Ile Asp Glu Cys Arg Asn Gly Ala Cys Val Pro Asn Ser Ile Cys 
        355                 360                 365             


Val Asn Thr Leu Gly Ser Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr 
    370                 375                 380                 


Thr Gly Asp Gln Ile Arg Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn 
385                 390                 395                 400 


Pro Glu Leu Asn Pro Cys Ser Val Asn Ala Gln Cys Ile Glu Glu Arg 
                405                 410                 415     


Gln Gly Asp Val Thr Cys Val Cys Gly Val Gly Trp Ala Gly Asp Gly 
            420                 425                 430         


Tyr Ile Cys Gly Lys Asp Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu 
        435                 440                 445             


Leu Pro Cys Ser Ala Arg Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val 
    450                 455                 460                 


Pro Asn Ser Gly Gln Glu Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala 
465                 470                 475                 480 


Cys Asp Glu Asp Ala Asp Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn 
                485                 490                 495     


Cys Val Leu Ile His Asn Val Asp Gln Arg Asn Ser Asp Lys Asp Ile 
            500                 505                 510         


Phe Gly Asp Ala Cys Asp Asn Cys Leu Ser Val Leu Asn Asn Asp Gln 
        515                 520                 525             


Lys Asp Thr Asp Gly Asp Gly Arg Gly Asp Ala Cys Asp Asp Asp Met 
    530                 535                 540                 


Asp Gly Asp Gly Ile Lys Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro 
545                 550                 555                 560 


Asn Arg Asp Gln Arg Asp Lys Asp Gly Asp Gly Val Gly Asp Ala Cys 
                565                 570                 575     


Asp Ser Cys Pro Asp Val Ser Asn Pro Asn Gln Ser Asp Val Asp Asn 
            580                 585                 590         


Asp Leu Val Gly Asp Ser Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp 
        595                 600                 605             


Gly His Gln Asp Ser Thr Asp Asn Cys Pro Thr Val Ile Asn Ser Ala 
    610                 615                 620                 


Gln Leu Asp Thr Asp Lys Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp 
625                 630                 635                 640 


Asp Asp Asn Asp Gly Ile Pro Asp Leu Val Pro Pro Gly Pro Asp Asn 
                645                 650                 655     


Cys Arg Leu Val Pro Asn Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly 
            660                 665                 670         


Val Gly Asp Ile Cys Glu Ser Asp Phe Asp Gln Asp Gln Val Ile Asp 
        675                 680                 685             


Arg Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe 
    690                 695                 700                 


Arg Ala Tyr Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile 
705                 710                 715                 720 


Asp Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val Gln Thr 
                725                 730                 735     


Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly 
            740                 745                 750         


Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Gln Thr Asp Asp Asp 
        755                 760                 765             


Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val 
    770                 775                 780                 


Val Met Trp Lys Gln Thr Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe 
785                 790                 795                 800 


Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Lys 
                805                 810                 815     


Thr Gly Pro Gly Glu His Leu Arg Asn Ser Leu Trp His Thr Gly Asp 
            820                 825                 830         


Thr Ser Asp Gln Val Arg Leu Leu Trp Lys Asp Ser Arg Asn Val Gly 
        835                 840                 845             


Trp Lys Asp Lys Val Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln 
    850                 855                 860                 


Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala 
865                 870                 875                 880 


Asp Ser Gly Val Thr Ile Asp Thr Thr Met Arg Gly Gly Arg Leu Gly 
                885                 890                 895     


Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr 
            900                 905                 910         


Arg Cys Asn Asp Thr Ile Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln 
        915                 920                 925             


Asn Phe Asp Arg Phe Asp Asn 
    930                 935 


<210>  8
<211>  3281
<212>  DNA
<213>  Homo sapiens

<400>  8
tcccccgccc ggccgcacca taaagcgccc ggccgctgcc gcggagccca gcagccagct       60

ccccagcacc gcacggcggg gacgcgagcg cgcccccgac ggcagcccgg acgccgagca      120

cgggtcacct gcggcgccgg cccgggcgcc gaccgaggtt caacgcacgg cccggggacc      180

cccaggcggg gccaacgccg ccgtcgcccc cggcctcgcg gggagcagga agagccaaca      240

tgctggcccc gcgcggagcc gccgtcctcc tgctgcacct ggtcctgcag cggtggctag      300

cggcaggcgc ccaggccacc ccccaggtct ttgaccttct cccatcttcc agtcagaggc      360

taaacccagg cgctctgctg ccagtcctga cagaccccgc cctgaatgat ctctatgtga      420

tttccacctt caagctgcag actaaaagtt cagccaccat cttcggtctt tactcttcaa      480

ctgacaacag taaatatttt gaatttactg tgatgggacg cttaaacaaa gccatcctcc      540

gttacctgaa gaacgatggg aaggtgcatt tggtggtttt caacaacctg cagctggcag      600

acggaaggcg gcacaggatc ctcctgaggc tgagcaattt gcagcgaggg gccggctccc      660

tagagctcta cctggactgc atccaggtgg attccgttca caatctcccc agggcctttg      720

ctggcccctc ccagaaacct gagaccattg aattgaggac tttccagagg aagccacagg      780

acttcttgga agagctgaag ctggtggtga gaggctcact gttccaggtg gccagcctgc      840

aagactgctt cctgcagcag agtgagccac tggctgccac aggcacaggg gactttaacc      900

ggcagttctt gggtcaaatg acacaattaa accaactcct gggagaggtg aaggaccttc      960

tgagacagca ggttaaggaa acatcatttt tgcgaaacac catagctgaa tgccaggctt     1020

gcggtcctct caagtttcag tctccgaccc caagcacggt ggtgcccccg gctccccctg     1080

caccgccaac acgcccacct cgtcggtgtg actccaaccc atgtttccga ggtgtccaat     1140

gtaccgacag tagagatggc ttccagtgtg ggccctgccc cgagggctac acaggaaacg     1200

ggatcacctg tattgatgtt gatgagtgca aataccatcc ctgctacccg ggcgtgcact     1260

gcataaattt gtctcctggc ttcagatgtg acgcctgccc agtgggcttc acagggccca     1320

tggtgcaggg tgttgggatc agttttgcca agtcaaacaa gcaggtctgc actgacattg     1380

atgagtgtcg aaatggagcg tgcgttccca actcgatctg cgttaatact ttgggatctt     1440

accgctgtgg gccttgtaag ccggggtata ctggtgatca gataagggga tgcaaagcgg     1500

aaagaaactg cagaaaccca gagctgaacc cttgcagtgt gaatgcccag tgcattgaag     1560

agaggcaggg ggatgtgaca tgtgtgtgtg gagtcggttg ggctggagat ggctatatct     1620

gtggaaagga tgtggacatc gacagttacc ccgacgaaga actgccatgc tctgccagga     1680

actgtaaaaa ggacaactgc aaatatgtgc caaattctgg ccaagaagat gcagacagag     1740

atggcattgg cgacgcttgt gacgaggatg ctgacggaga tgggatcctg aatgagcagg     1800

ataactgtgt cctgattcat aatgtggacc aaaggaacag cgataaagat atctttgggg     1860

atgcctgtga taactgcctg agtgtcttaa ataacgacca gaaagacacc gatggggatg     1920

gaagaggaga tgcctgtgat gatgacatgg atggagatgg aataaaaaac attctggaca     1980

actgcccaaa atttcccaat cgtgaccaac gggacaagga tggtgatggt gtgggggatg     2040

cctgtgacag ttgtcctgat gtcagcaacc ctaaccagtc tgatgtggat aatgatctgg     2100

ttggggactc ctgtgacacc aatcaggaca gtgatggaga tgggcaccag gacagcacag     2160

acaactgccc caccgtcatt aacagtgccc agctggacac cgataaggat ggaattggtg     2220

acgagtgtga tgatgatgat gacaatgatg gtatcccaga cctggtgccc cctggaccag     2280

acaactgccg gctggtcccc aacccagccc aggaggatag caacagcgac ggagtgggag     2340

acatctgtga gtctgacttt gaccaggacc aggtcatcga tcggatcgac gtctgcccag     2400

agaacgcaga ggtcaccctg accgacttca gggcttacca gaccgtggtc ctggatcctg     2460

aaggggatgc ccagatcgat cccaactggg tggtcctgaa ccagggcatg gagattgtac     2520

agaccatgaa cagtgatcct ggcctggcag tggggtacac agcttttaat ggagttgact     2580

tcgaagggac cttccatgtg aatacccaga cagatgatga ctatgcaggc tttatctttg     2640

gctaccaaga tagctccagc ttctacgtgg tcatgtggaa gcagacggag cagacatatt     2700

ggcaagccac cccattccga gcagttgcag aacctggcat tcagctcaag gctgtgaagt     2760

ctaagacagg tccaggggag catctccgga actccctgtg gcacacgggg gacaccagtg     2820

accaggtcag gctgctgtgg aaggactcca ggaatgtggg ctggaaggac aaggtgtcct     2880

accgctggtt cctacagcac aggccccagg tgggctacat cagggtacga ttttatgaag     2940

gctctgagtt ggtggctgac tctggcgtca ccatagacac cacaatgcgt ggaggccgac     3000

ttggcgtttt ctgcttctct caagaaaaca tcatctggtc caacctcaag tatcgctgca     3060

atgacaccat ccctgaggac ttccaagagt ttcaaaccca gaatttcgac cgcttcgata     3120

attaaaccaa ggaagcaatc tgtaactgct tttcggaaca ctaaaaccat atatatttta     3180

acttcaattt tctttagctt ttaccaaccc aaatatatca aaacgtttta tgtgaatgtg     3240

gcaataaagg agaagagatc atttttaaaa aaaaaaaaaa a                         3281


<210>  9
<211>  3115
<212>  DNA
<213>  Homo sapiens

<400>  9
gtgaaacgcg ggggcgtggc taagggaggg aagggtaatt tgggggctct tgagagatga       60

gagaaacaac gactggaggg attaagaaga actcttagga gcagcttggc ctaaaggctg      120

tgtgggacgt gcctgctttg ccttcgcctt ccaccatgat ctctttgacc ttctcccatc      180

ttccagtcag aggctaaacc caggcgctct gctgccagtc ctgacagacc ccgccctgaa      240

tgatctctat gtgatttcca ccttcaagct gcagactaaa agttcagcca ccatcttcgg      300

tctttactct tcaactgaca acagtaaata ttttgaattt actgtgatgg gacgcttaaa      360

caaagccatc ctccgttacc tgaagaacga tgggaaggtg catttggtgg ttttcaacaa      420

cctgcagctg gcagacggaa ggcggcacag gatcctcctg aggctgagca atttgcagcg      480

aggggccggc tccctagagc tctacctgga ctgcatccag gtggattccg ttcacaatct      540

ccccagggcc tttgctggcc cctcccagaa acctgagacc attgaattga ggactttcca      600

gaggaagcca caggacttct tggaagagct gaagctggtg gtgagaggct cactgttcca      660

ggtggccagc ctgcaagact gcttcctgca gcagagtgag ccactggctg ccacaggcac      720

aggggacttt aaccggcagt tcttgggtca aatgacacaa ttaaaccaac tcctgggaga      780

ggtgaaggac cttctgagac agcaggttaa ggaaacatca tttttgcgaa acaccatagc      840

tgaatgccag gcttgcggtc ctctcaagtt tcagtctccg accccaagca cggtggtgcc      900

cccggctccc cctgcaccgc caacacgccc acctcgtcgg tgtgactcca acccatgttt      960

ccgaggtgtc caatgtaccg acagtagaga tggcttccag tgtgggccct gccccgaggg     1020

ctacacagga aacgggatca cctgtattga tgttgatgag tgcaaatacc atccctgcta     1080

cccgggcgtg cactgcataa atttgtctcc tggcttcaga tgtgacgcct gcccagtggg     1140

cttcacaggg cccatggtgc agggtgttgg gatcagtttt gccaagtcaa acaagcaggt     1200

ctgcactgac attgatgagt gtcgaaatgg agcgtgcgtt cccaactcga tctgcgttaa     1260

tactttggga tcttaccgct gtgggccttg taagccgggg tatactggtg atcagataag     1320

gggatgcaaa gcggaaagaa actgcagaaa cccagagctg aacccttgca gtgtgaatgc     1380

ccagtgcatt gaagagaggc agggggatgt gacatgtgtg tgtggagtcg gttgggctgg     1440

agatggctat atctgtggaa aggatgtgga catcgacagt taccccgacg aagaactgcc     1500

atgctctgcc aggaactgta aaaaggacaa ctgcaaatat gtgccaaatt ctggccaaga     1560

agatgcagac agagatggca ttggcgacgc ttgtgacgag gatgctgacg gagatgggat     1620

cctgaatgag caggataact gtgtcctgat tcataatgtg gaccaaagga acagcgataa     1680

agatatcttt ggggatgcct gtgataactg cctgagtgtc ttaaataacg accagaaaga     1740

caccgatggg gatggaagag gagatgcctg tgatgatgac atggatggag atggaataaa     1800

aaacattctg gacaactgcc caaaatttcc caatcgtgac caacgggaca aggatggtga     1860

tggtgtgggg gatgcctgtg acagttgtcc tgatgtcagc aaccctaacc agtctgatgt     1920

ggataatgat ctggttgggg actcctgtga caccaatcag gacagtgatg gagatgggca     1980

ccaggacagc acagacaact gccccaccgt cattaacagt gcccagctgg acaccgataa     2040

ggatggaatt ggtgacgagt gtgatgatga tgatgacaat gatggtatcc cagacctggt     2100

gccccctgga ccagacaact gccggctggt ccccaaccca gcccaggagg atagcaacag     2160

cgacggagtg ggagacatct gtgagtctga ctttgaccag gaccaggtca tcgatcggat     2220

cgacgtctgc ccagagaacg cagaggtcac cctgaccgac ttcagggctt accagaccgt     2280

ggtcctggat cctgaagggg atgcccagat cgatcccaac tgggtggtcc tgaaccaggg     2340

catggagatt gtacagacca tgaacagtga tcctggcctg gcagtggggt acacagcttt     2400

taatggagtt gacttcgaag ggaccttcca tgtgaatacc cagacagatg atgactatgc     2460

aggctttatc tttggctacc aagatagctc cagcttctac gtggtcatgt ggaagcagac     2520

ggagcagaca tattggcaag ccaccccatt ccgagcagtt gcagaacctg gcattcagct     2580

caaggctgtg aagtctaaga caggtccagg ggagcatctc cggaactccc tgtggcacac     2640

gggggacacc agtgaccagg tcaggctgct gtggaaggac tccaggaatg tgggctggaa     2700

ggacaaggtg tcctaccgct ggttcctaca gcacaggccc caggtgggct acatcagggt     2760

acgattttat gaaggctctg agttggtggc tgactctggc gtcaccatag acaccacaat     2820

gcgtggaggc cgacttggcg ttttctgctt ctctcaagaa aacatcatct ggtccaacct     2880

caagtatcgc tgcaatgaca ccatccctga ggacttccaa gagtttcaaa cccagaattt     2940

cgaccgcttc gataattaaa ccaaggaagc aatctgtaac tgcttttcgg aacactaaaa     3000

ccatatatat tttaacttca attttcttta gcttttacca acccaaatat atcaaaacgt     3060

tttatgtgaa tgtggcaata aaggagaaga gatcattttt aaaaaaaaaa aaaaa          3115


<210>  10
<211>  3166
<212>  DNA
<213>  Homo sapiens

<400>  10
tgaaacgcgg gggcgtggct aagggaggga agggtaattt gggggctctt gagagatgag       60

agaaacaacg actggaggga ttaagaagaa ctcttaggag cagcttggcc taaaggctgt      120

gtgggacgtg cctgctttgc cttcgccttc caccatgatc gtaagttttc tgagaccccc      180

tcagccatgt ttcctgtaga gcctgtggag tttctttgac cttctcccat cttccagtca      240

gaggctaaac ccaggcgctc tgctgccagt cctgacagac cccgccctga atgatctcta      300

tgtgatttcc accttcaagc tgcagactaa aagttcagcc accatcttcg gtctttactc      360

ttcaactgac aacagtaaat attttgaatt tactgtgatg ggacgcttaa acaaagccat      420

cctccgttac ctgaagaacg atgggaaggt gcatttggtg gttttcaaca acctgcagct      480

ggcagacgga aggcggcaca ggatcctcct gaggctgagc aatttgcagc gaggggccgg      540

ctccctagag ctctacctgg actgcatcca ggtggattcc gttcacaatc tccccagggc      600

ctttgctggc ccctcccaga aacctgagac cattgaattg aggactttcc agaggaagcc      660

acaggacttc ttggaagagc tgaagctggt ggtgagaggc tcactgttcc aggtggccag      720

cctgcaagac tgcttcctgc agcagagtga gccactggct gccacaggca caggggactt      780

taaccggcag ttcttgggtc aaatgacaca attaaaccaa ctcctgggag aggtgaagga      840

ccttctgaga cagcaggtta aggaaacatc atttttgcga aacaccatag ctgaatgcca      900

ggcttgcggt cctctcaagt ttcagtctcc gaccccaagc acggtggtgc ccccggctcc      960

ccctgcaccg ccaacacgcc cacctcgtcg gtgtgactcc aacccatgtt tccgaggtgt     1020

ccaatgtacc gacagtagag atggcttcca gtgtgggccc tgccccgagg gctacacagg     1080

aaacgggatc acctgtattg atgttgatga gtgcaaatac catccctgct acccgggcgt     1140

gcactgcata aatttgtctc ctggcttcag atgtgacgcc tgcccagtgg gcttcacagg     1200

gcccatggtg cagggtgttg ggatcagttt tgccaagtca aacaagcagg tctgcactga     1260

cattgatgag tgtcgaaatg gagcgtgcgt tcccaactcg atctgcgtta atactttggg     1320

atcttaccgc tgtgggcctt gtaagccggg gtatactggt gatcagataa ggggatgcaa     1380

agcggaaaga aactgcagaa acccagagct gaacccttgc agtgtgaatg cccagtgcat     1440

tgaagagagg cagggggatg tgacatgtgt gtgtggagtc ggttgggctg gagatggcta     1500

tatctgtgga aaggatgtgg acatcgacag ttaccccgac gaagaactgc catgctctgc     1560

caggaactgt aaaaaggaca actgcaaata tgtgccaaat tctggccaag aagatgcaga     1620

cagagatggc attggcgacg cttgtgacga ggatgctgac ggagatggga tcctgaatga     1680

gcaggataac tgtgtcctga ttcataatgt ggaccaaagg aacagcgata aagatatctt     1740

tggggatgcc tgtgataact gcctgagtgt cttaaataac gaccagaaag acaccgatgg     1800

ggatggaaga ggagatgcct gtgatgatga catggatgga gatggaataa aaaacattct     1860

ggacaactgc ccaaaatttc ccaatcgtga ccaacgggac aaggatggtg atggtgtggg     1920

ggatgcctgt gacagttgtc ctgatgtcag caaccctaac cagtctgatg tggataatga     1980

tctggttggg gactcctgtg acaccaatca ggacagtgat ggagatgggc accaggacag     2040

cacagacaac tgccccaccg tcattaacag tgcccagctg gacaccgata aggatggaat     2100

tggtgacgag tgtgatgatg atgatgacaa tgatggtatc ccagacctgg tgccccctgg     2160

accagacaac tgccggctgg tccccaaccc agcccaggag gatagcaaca gcgacggagt     2220

gggagacatc tgtgagtctg actttgacca ggaccaggtc atcgatcgga tcgacgtctg     2280

cccagagaac gcagaggtca ccctgaccga cttcagggct taccagaccg tggtcctgga     2340

tcctgaaggg gatgcccaga tcgatcccaa ctgggtggtc ctgaaccagg gcatggagat     2400

tgtacagacc atgaacagtg atcctggcct ggcagtgggg tacacagctt ttaatggagt     2460

tgacttcgaa gggaccttcc atgtgaatac ccagacagat gatgactatg caggctttat     2520

ctttggctac caagatagct ccagcttcta cgtggtcatg tggaagcaga cggagcagac     2580

atattggcaa gccaccccat tccgagcagt tgcagaacct ggcattcagc tcaaggctgt     2640

gaagtctaag acaggtccag gggagcatct ccggaactcc ctgtggcaca cgggggacac     2700

cagtgaccag gtcaggctgc tgtggaagga ctccaggaat gtgggctgga aggacaaggt     2760

gtcctaccgc tggttcctac agcacaggcc ccaggtgggc tacatcaggg tacgatttta     2820

tgaaggctct gagttggtgg ctgactctgg cgtcaccata gacaccacaa tgcgtggagg     2880

ccgacttggc gttttctgct tctctcaaga aaacatcatc tggtccaacc tcaagtatcg     2940

ctgcaatgac accatccctg aggacttcca agagtttcaa acccagaatt tcgaccgctt     3000

cgataattaa accaaggaag caatctgtaa ctgcttttcg gaacactaaa accatatata     3060

ttttaacttc aattttcttt agcttttacc aacccaaata tatcaaaacg ttttatgtga     3120

atgtggcaat aaaggagaag agatcatttt taaaaaaaaa aaaaaa                    3166


<210>  11
<211>  3109
<212>  DNA
<213>  Homo sapiens

<400>  11
ggagcgatgt atgcccagag tctgctcttg acatccctga gaaagacgca gaattactct       60

acttgccctg ccacctgcat tttctgctct gactttgctt gaacgacaaa aagaaagttt      120

atttcaagga ttggcttgat gtcttaattt ctgagtcttt gaccttctcc catcttccag      180

tcagaggcta aacccaggcg ctctgctgcc agtcctgaca gaccccgccc tgaatgatct      240

ctatgtgatt tccaccttca agctgcagac taaaagttca gccaccatct tcggtcttta      300

ctcttcaact gacaacagta aatattttga atttactgtg atgggacgct taaacaaagc      360

catcctccgt tacctgaaga acgatgggaa ggtgcatttg gtggttttca acaacctgca      420

gctggcagac ggaaggcggc acaggatcct cctgaggctg agcaatttgc agcgaggggc      480

cggctcccta gagctctacc tggactgcat ccaggtggat tccgttcaca atctccccag      540

ggcctttgct ggcccctccc agaaacctga gaccattgaa ttgaggactt tccagaggaa      600

gccacaggac ttcttggaag agctgaagct ggtggtgaga ggctcactgt tccaggtggc      660

cagcctgcaa gactgcttcc tgcagcagag tgagccactg gctgccacag gcacagggga      720

ctttaaccgg cagttcttgg gtcaaatgac acaattaaac caactcctgg gagaggtgaa      780

ggaccttctg agacagcagg ttaaggaaac atcatttttg cgaaacacca tagctgaatg      840

ccaggcttgc ggtcctctca agtttcagtc tccgacccca agcacggtgg tgcccccggc      900

tccccctgca ccgccaacac gcccacctcg tcggtgtgac tccaacccat gtttccgagg      960

tgtccaatgt accgacagta gagatggctt ccagtgtggg ccctgccccg agggctacac     1020

aggaaacggg atcacctgta ttgatgttga tgagtgcaaa taccatccct gctacccggg     1080

cgtgcactgc ataaatttgt ctcctggctt cagatgtgac gcctgcccag tgggcttcac     1140

agggcccatg gtgcagggtg ttgggatcag ttttgccaag tcaaacaagc aggtctgcac     1200

tgacattgat gagtgtcgaa atggagcgtg cgttcccaac tcgatctgcg ttaatacttt     1260

gggatcttac cgctgtgggc cttgtaagcc ggggtatact ggtgatcaga taaggggatg     1320

caaagcggaa agaaactgca gaaacccaga gctgaaccct tgcagtgtga atgcccagtg     1380

cattgaagag aggcaggggg atgtgacatg tgtgtgtgga gtcggttggg ctggagatgg     1440

ctatatctgt ggaaaggatg tggacatcga cagttacccc gacgaagaac tgccatgctc     1500

tgccaggaac tgtaaaaagg acaactgcaa atatgtgcca aattctggcc aagaagatgc     1560

agacagagat ggcattggcg acgcttgtga cgaggatgct gacggagatg ggatcctgaa     1620

tgagcaggat aactgtgtcc tgattcataa tgtggaccaa aggaacagcg ataaagatat     1680

ctttggggat gcctgtgata actgcctgag tgtcttaaat aacgaccaga aagacaccga     1740

tggggatgga agaggagatg cctgtgatga tgacatggat ggagatggaa taaaaaacat     1800

tctggacaac tgcccaaaat ttcccaatcg tgaccaacgg gacaaggatg gtgatggtgt     1860

gggggatgcc tgtgacagtt gtcctgatgt cagcaaccct aaccagtctg atgtggataa     1920

tgatctggtt ggggactcct gtgacaccaa tcaggacagt gatggagatg ggcaccagga     1980

cagcacagac aactgcccca ccgtcattaa cagtgcccag ctggacaccg ataaggatgg     2040

aattggtgac gagtgtgatg atgatgatga caatgatggt atcccagacc tggtgccccc     2100

tggaccagac aactgccggc tggtccccaa cccagcccag gaggatagca acagcgacgg     2160

agtgggagac atctgtgagt ctgactttga ccaggaccag gtcatcgatc ggatcgacgt     2220

ctgcccagag aacgcagagg tcaccctgac cgacttcagg gcttaccaga ccgtggtcct     2280

ggatcctgaa ggggatgccc agatcgatcc caactgggtg gtcctgaacc agggcatgga     2340

gattgtacag accatgaaca gtgatcctgg cctggcagtg gggtacacag cttttaatgg     2400

agttgacttc gaagggacct tccatgtgaa tacccagaca gatgatgact atgcaggctt     2460

tatctttggc taccaagata gctccagctt ctacgtggtc atgtggaagc agacggagca     2520

gacatattgg caagccaccc cattccgagc agttgcagaa cctggcattc agctcaaggc     2580

tgtgaagtct aagacaggtc caggggagca tctccggaac tccctgtggc acacggggga     2640

caccagtgac caggtcaggc tgctgtggaa ggactccagg aatgtgggct ggaaggacaa     2700

ggtgtcctac cgctggttcc tacagcacag gccccaggtg ggctacatca gggtacgatt     2760

ttatgaaggc tctgagttgg tggctgactc tggcgtcacc atagacacca caatgcgtgg     2820

aggccgactt ggcgttttct gcttctctca agaaaacatc atctggtcca acctcaagta     2880

tcgctgcaat gacaccatcc ctgaggactt ccaagagttt caaacccaga atttcgaccg     2940

cttcgataat taaaccaagg aagcaatctg taactgcttt tcggaacact aaaaccatat     3000

atattttaac ttcaattttc tttagctttt accaacccaa atatatcaaa acgttttatg     3060

tgaatgtggc aataaaggag aagagatcat ttttaaaaaa aaaaaaaaa                 3109


<210>  12
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Asn Ser Glu Arg Ala Glu Glu Met Gln Glu Asn Tyr Gln Arg 
1               5                   10                  15      


Asn Gly Thr Ala Glu Glu Gln Pro Lys Leu Arg Lys Glu Ala Val Gly 
            20                  25                  30          


Ser Ile Glu Ile Phe Arg Phe Ala Asp Gly Leu Asp Ile Thr Leu Met 
        35                  40                  45              


Ile Leu Gly Ile Leu Ala Ser Leu Val Asn Gly Ala Cys Leu Pro Leu 
    50                  55                  60                  


Met Pro Leu Val Leu Gly Glu Met Ser Asp Asn Leu Ile Ser Gly Cys 
65                  70                  75                  80  


Leu Val Gln Thr Asn Thr Thr Asn Tyr Gln Asn Cys Thr Gln Ser Gln 
                85                  90                  95      


Glu Lys Leu Asn Glu Asp Met Thr Leu Leu Thr Leu Tyr Tyr Val Gly 
            100                 105                 110         


Ile Gly Val Ala Ala Leu Ile Phe Gly Tyr Ile Gln Ile Ser Leu Trp 
        115                 120                 125             


Ile Ile Thr Ala Ala Arg Gln Thr Lys Arg Ile Arg Lys Gln Phe Phe 
    130                 135                 140                 


His Ser Val Leu Ala Gln Asp Ile Gly Trp Phe Asp Ser Cys Asp Ile 
145                 150                 155                 160 


Gly Glu Leu Asn Thr Arg Met Thr Asp Asp Ile Asp Lys Ile Ser Asp 
                165                 170                 175     


Gly Ile Gly Asp Lys Ile Ala Leu Leu Phe Gln Asn Met Ser Thr Phe 
            180                 185                 190         


Ser Ile Gly Leu Ala Val Gly Leu Val Lys Gly Trp Lys Leu Thr Leu 
        195                 200                 205             


Val Thr Leu Ser Thr Ser Pro Leu Ile Met Ala Ser Ala Ala Ala Cys 
    210                 215                 220                 


Ser Arg Met Val Ile Ser Leu Thr Ser Lys Glu Leu Ser Ala Tyr Ser 
225                 230                 235                 240 


Lys Ala Gly Ala Val Ala Glu Glu Val Leu Ser Ser Ile Arg Thr Val 
                245                 250                 255     


Ile Ala Phe Arg Ala Gln Glu Lys Glu Leu Gln Arg Tyr Thr Gln Asn 
            260                 265                 270         


Leu Lys Asp Ala Lys Asp Phe Gly Ile Lys Arg Thr Ile Ala Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Ala Val Tyr Phe Phe Met Asn Gly Thr Tyr Gly Leu 
    290                 295                 300                 


Ala Phe Trp Tyr Gly Thr Ser Leu Ile Leu Asn Gly Glu Pro Gly Tyr 
305                 310                 315                 320 


Thr Ile Gly Thr Val Leu Ala Val Phe Phe Ser Val Ile His Ser Ser 
                325                 330                 335     


Tyr Cys Ile Gly Ala Ala Val Pro His Phe Glu Thr Phe Ala Ile Ala 
            340                 345                 350         


Arg Gly Ala Ala Phe His Ile Phe Gln Val Ile Asp Lys Lys Pro Ser 
        355                 360                 365             


Ile Asp Asn Phe Ser Thr Ala Gly Tyr Lys Pro Glu Ser Ile Glu Gly 
    370                 375                 380                 


Thr Val Glu Phe Lys Asn Val Ser Phe Asn Tyr Pro Ser Arg Pro Ser 
385                 390                 395                 400 


Ile Lys Ile Leu Lys Gly Leu Asn Leu Arg Ile Lys Ser Gly Glu Thr 
                405                 410                 415     


Val Ala Leu Val Gly Leu Asn Gly Ser Gly Lys Ser Thr Val Val Gln 
            420                 425                 430         


Leu Leu Gln Arg Leu Tyr Asp Pro Asp Asp Gly Phe Ile Met Val Asp 
        435                 440                 445             


Glu Asn Asp Ile Arg Ala Leu Asn Val Arg His Tyr Arg Asp His Ile 
    450                 455                 460                 


Gly Val Val Ser Gln Glu Pro Val Leu Phe Gly Thr Thr Ile Ser Asn 
465                 470                 475                 480 


Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr Asp Glu Glu Met Glu Arg 
                485                 490                 495     


Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe Ile Met Glu Phe Pro Asn 
            500                 505                 510         


Lys Phe Asn Thr Leu Val Gly Glu Lys Gly Ala Gln Met Ser Gly Gly 
        515                 520                 525             


Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg Asn Pro Lys 
    530                 535                 540                 


Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser Glu Ser Lys 
545                 550                 555                 560 


Ser Ala Val Gln Ala Ala Leu Glu Lys Ala Ser Lys Gly Arg Thr Thr 
                565                 570                 575     


Ile Val Val Ala His Arg Leu Ser Thr Ile Arg Ser Ala Asp Leu Ile 
            580                 585                 590         


Val Thr Leu Lys Asp Gly Met Leu Ala Glu Lys Gly Ala His Ala Glu 
        595                 600                 605             


Leu Met Ala Lys Arg Gly Leu Tyr Tyr Ser Leu Val Met Ser Gln Asp 
    610                 615                 620                 


Ile Lys Lys Ala Asp Glu Gln Met Glu Ser Met Thr Tyr Ser Thr Glu 
625                 630                 635                 640 


Arg Lys Thr Asn Ser Leu Pro Leu His Ser Val Lys Ser Ile Lys Ser 
                645                 650                 655     


Asp Phe Ile Asp Lys Ala Glu Glu Ser Thr Gln Ser Lys Glu Ile Ser 
            660                 665                 670         


Leu Pro Glu Val Ser Leu Leu Lys Ile Leu Lys Leu Asn Lys Pro Glu 
        675                 680                 685             


Trp Pro Phe Val Val Leu Gly Thr Leu Ala Ser Val Leu Asn Gly Thr 
    690                 695                 700                 


Val His Pro Val Phe Ser Ile Ile Phe Ala Lys Ile Ile Thr Met Phe 
705                 710                 715                 720 


Gly Asn Asn Asp Lys Thr Thr Leu Lys His Asp Ala Glu Ile Tyr Ser 
                725                 730                 735     


Met Ile Phe Val Ile Leu Gly Val Ile Cys Phe Val Ser Tyr Phe Met 
            740                 745                 750         


Gln Gly Leu Phe Tyr Gly Arg Ala Gly Glu Ile Leu Thr Met Arg Leu 
        755                 760                 765             


Arg His Leu Ala Phe Lys Ala Met Leu Tyr Gln Asp Ile Ala Trp Phe 
    770                 775                 780                 


Asp Glu Lys Glu Asn Ser Thr Gly Gly Leu Thr Thr Ile Leu Ala Ile 
785                 790                 795                 800 


Asp Ile Ala Gln Ile Gln Gly Ala Thr Gly Ser Arg Ile Gly Val Leu 
                805                 810                 815     


Thr Gln Asn Ala Thr Asn Met Gly Leu Ser Val Ile Ile Ser Phe Ile 
            820                 825                 830         


Tyr Gly Trp Glu Met Thr Phe Leu Ile Leu Ser Ile Ala Pro Val Leu 
        835                 840                 845             


Ala Val Thr Gly Met Ile Glu Thr Ala Ala Met Thr Gly Phe Ala Asn 
    850                 855                 860                 


Lys Asp Lys Gln Glu Leu Lys His Ala Gly Lys Ile Ala Thr Glu Ala 
865                 870                 875                 880 


Leu Glu Asn Ile Arg Thr Ile Val Ser Leu Thr Arg Glu Lys Ala Phe 
                885                 890                 895     


Glu Gln Met Tyr Glu Glu Met Leu Gln Thr Gln His Arg Asn Thr Ser 
            900                 905                 910         


Lys Lys Ala Gln Ile Ile Gly Ser Cys Tyr Ala Phe Ser His Ala Phe 
        915                 920                 925             


Ile Tyr Phe Ala Tyr Ala Ala Gly Phe Arg Phe Gly Ala Tyr Leu Ile 
    930                 935                 940                 


Gln Ala Gly Arg Met Thr Pro Glu Gly Met Phe Ile Val Phe Thr Ala 
945                 950                 955                 960 


Ile Ala Tyr Gly Ala Met Ala Ile Gly Glu Thr Leu Val Leu Ala Pro 
                965                 970                 975     


Glu Tyr Ser Lys Ala Lys Ser Gly Ala Ala His Leu Phe Ala Leu Leu 
            980                 985                 990         


Glu Lys Lys Pro Asn Ile Asp Ser  Arg Ser Gln Glu Gly  Lys Lys Pro 
        995                 1000                 1005             


Asp Thr  Cys Glu Gly Asn Leu  Glu Phe Arg Glu Val  Ser Phe Phe 
    1010                 1015                 1020             


Tyr Pro  Cys Arg Pro Asp Val  Phe Ile Leu Arg Gly  Leu Ser Leu 
    1025                 1030                 1035             


Ser Ile  Glu Arg Gly Lys Thr  Val Ala Phe Val Gly  Ser Ser Gly 
    1040                 1045                 1050             


Cys Gly  Lys Ser Thr Ser Val  Gln Leu Leu Gln Arg  Leu Tyr Asp 
    1055                 1060                 1065             


Pro Val  Gln Gly Gln Val Leu  Phe Asp Gly Val Asp  Ala Lys Glu 
    1070                 1075                 1080             


Leu Asn  Val Gln Trp Leu Arg  Ser Gln Ile Ala Ile  Val Pro Gln 
    1085                 1090                 1095             


Glu Pro  Val Leu Phe Asn Cys  Ser Ile Ala Glu Asn  Ile Ala Tyr 
    1100                 1105                 1110             


Gly Asp  Asn Ser Arg Val Val  Pro Leu Asp Glu Ile  Lys Glu Ala 
    1115                 1120                 1125             


Ala Asn  Ala Ala Asn Ile His  Ser Phe Ile Glu Gly  Leu Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Asn Thr Gln Val Gly  Leu Lys Gly Ala Gln  Leu Ser Gly 
    1145                 1150                 1155             


Gly Gln  Lys Gln Arg Leu Ala  Ile Ala Arg Ala Leu  Leu Gln Lys 
    1160                 1165                 1170             


Pro Lys  Ile Leu Leu Leu Asp  Glu Ala Thr Ser Ala  Leu Asp Asn 
    1175                 1180                 1185             


Asp Ser  Glu Lys Val Val Gln  His Ala Leu Asp Lys  Ala Arg Thr 
    1190                 1195                 1200             


Gly Arg  Thr Cys Leu Val Val  Thr His Arg Leu Ser  Ala Ile Gln 
    1205                 1210                 1215             


Asn Ala  Asp Leu Ile Val Val  Leu His Asn Gly Lys  Ile Lys Glu 
    1220                 1225                 1230             


Gln Gly  Thr His Gln Glu Leu  Leu Arg Asn Arg Asp  Ile Tyr Phe 
    1235                 1240                 1245             


Lys Leu  Val Asn Ala Gln Ser  Val Gln 
    1250                 1255         


<210>  13
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Asp Glu Asn Asp Ile Arg Ala Leu Asn Val Arg His Tyr Arg 
1               5                   10                  15      


Asp His Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe Gly Thr Thr 
            20                  25                  30          


Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr Asp Glu Glu 
        35                  40                  45              


Met Glu Arg Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe Ile Met Glu 
    50                  55                  60                  


Phe Pro Asn Lys Phe Asn Thr Leu Val Gly Glu Lys Gly Ala Gln Met 
65                  70                  75                  80  


Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg 
                85                  90                  95      


Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser 
            100                 105                 110         


Glu Ser Lys Ser Ala Val Gln Ala Ala Leu Glu Lys Asp Thr Pro Arg 
        115                 120                 125             


Tyr Ser Phe 
    130     


<210>  14
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Asp Glu Asn Asp Ile Arg Ala Leu Asn Val Arg His Tyr Arg 
1               5                   10                  15      


Asp His Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe Gly Thr Thr 
            20                  25                  30          


Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr Asp Glu Glu 
        35                  40                  45              


Met Glu Arg Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe Ile Met Glu 
    50                  55                  60                  


Phe Pro Asn Lys Phe Asn Thr Leu Val Gly Glu Lys Gly Ala Gln Met 
65                  70                  75                  80  


Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg 
                85                  90                  95      


Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser 
            100                 105                 110         


Glu Ser Lys Ser Ala Val Gln Ala Ala Leu Glu Lys Lys Lys 
        115                 120                 125     


<210>  15
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Asp Glu Asn Asp Ile Arg Ala Leu Asn Val Arg His Tyr Arg 
1               5                   10                  15      


Asp His Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe Gly Thr Thr 
            20                  25                  30          


Ile Ser Asn Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr Asp Glu Glu 
        35                  40                  45              


Met Glu Arg Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe Ile Met Glu 
    50                  55                  60                  


Phe Pro Asn Lys Phe Asn Thr Leu Val Gly Glu Lys Gly Ala Gln Met 
65                  70                  75                  80  


Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg 
                85                  90                  95      


Asn Pro Lys Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser 
            100                 105                 110         


Glu Ser Lys Ser Ala Val Gln Ala Ala Leu Glu Lys Ala Ser Lys Gly 
        115                 120                 125             


Arg Thr Thr Ile Val Val Ala His Arg Leu Ser Thr Ile Arg Ser Ala 
    130                 135                 140                 


Asp Leu Ile Val Thr Leu Lys Asp Gly Met Leu Ala Glu Lys Gly Ala 
145                 150                 155                 160 


His Ala Glu Leu Met Ala Lys Arg Gly Leu Tyr Tyr Ser Leu Val Met 
                165                 170                 175     


Ser Gln Asp Ile Lys Lys Ala Asp Glu Gln Met Glu Ser Met Thr Tyr 
            180                 185                 190         


Ser Thr Glu Arg Lys Thr Asn Ser Leu Pro Leu His Ser Val Lys Ser 
        195                 200                 205             


Ile Lys Ser Asp Phe Ile Asp Lys Ala Glu Glu Ser Thr Gln Ser Lys 
    210                 215                 220                 


Glu Ile Ser Leu Pro Glu Val Ser Leu Leu Lys Ile Leu Lys Leu Asn 
225                 230                 235                 240 


Lys Pro Glu Trp Pro Phe Val Val Leu Gly Thr Leu Ala Ser Val Leu 
                245                 250                 255     


Asn Gly Thr Val His Pro Val Phe Ser Ile Ile Phe Ala Lys Ile Ile 
            260                 265                 270         


Thr Met Phe Gly Asn Asn Asp Lys Thr Thr Leu Lys His Asp Ala Glu 
        275                 280                 285             


Ile Tyr Ser Met Ile Phe Val Ile Leu Gly Val Ile Cys Phe Val Ser 
    290                 295                 300                 


Tyr Phe Met Gln Gly Leu Phe Tyr Gly Arg Ala Gly Glu Ile Leu Thr 
305                 310                 315                 320 


Met Arg Leu Arg His Leu Ala Phe Lys Ala Met Leu Tyr Gln Asp Ile 
                325                 330                 335     


Ala Trp Phe Asp Glu Lys Glu Asn Ser Thr Gly Gly Leu Thr Thr Ile 
            340                 345                 350         


Leu Ala Ile Asp Ile Ala Gln Ile Gln Gly Ala Thr Gly Ser Arg Ile 
        355                 360                 365             


Gly Val Leu Thr Gln Asn Ala Thr Asn Met Gly Leu Ser Val Ile Ile 
    370                 375                 380                 


Ser Phe Ile Tyr Gly Trp Glu Met Thr Phe Leu Ile Leu Ser Ile Ala 
385                 390                 395                 400 


Pro Val Leu Ala Val Thr Gly Met Ile Glu Thr Ala Ala Met Thr Gly 
                405                 410                 415     


Phe Ala Asn Lys Asp Lys Gln Glu Leu Lys His Ala Gly Lys Ile Ala 
            420                 425                 430         


Thr Glu Ala Leu Glu Asn Ile Arg Thr Ile Val Ser Leu Thr Arg Glu 
        435                 440                 445             


Lys Ala Phe Glu Gln Met Tyr Glu Glu Met Leu Gln Thr Gln His Arg 
    450                 455                 460                 


Asn Thr Ser Lys Lys Ala Gln Ile Ile Gly Ser Cys Tyr Ala Phe Ser 
465                 470                 475                 480 


His Ala Phe Ile Tyr Phe Ala Tyr Ala Ala Gly Phe Arg Phe Gly Ala 
                485                 490                 495     


Tyr Leu Ile Gln Ala Gly Arg Met Thr Pro Glu Gly Met Phe Ile Val 
            500                 505                 510         


Phe Thr Ala Ile Ala Tyr Gly Ala Met Ala Ile Gly Glu Thr Leu Val 
        515                 520                 525             


Leu Ala Pro Glu Tyr Ser Lys Ala Lys Ser Gly Ala Ala His Leu Phe 
    530                 535                 540                 


Ala Leu Leu Glu Lys Lys Pro Asn Ile Asp Ser Arg Ser Gln Glu Gly 
545                 550                 555                 560 


Lys Lys Pro Asp Thr Cys Glu Gly Asn Leu Glu Phe Arg Glu Val Ser 
                565                 570                 575     


Phe Phe Tyr Pro Cys Arg Pro Asp Val Phe Ile Leu Arg Gly Leu Ser 
            580                 585                 590         


Leu Ser Ile Glu Arg Gly Lys Thr Val Ala Phe Val Gly Ser Ser Gly 
        595                 600                 605             


Cys Gly Lys Ser Thr Ser Val Gln Leu Leu Gln Arg Leu Tyr Asp Pro 
    610                 615                 620                 


Val Gln Gly Gln Val Leu Phe Asp Gly Val Asp Ala Lys Glu Leu Asn 
625                 630                 635                 640 


Val Gln Trp Leu Arg Ser Gln Ile Ala Ile Val Pro Gln Glu Pro Val 
                645                 650                 655     


Leu Phe Asn Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn Ser 
            660                 665                 670         


Arg Val Val Pro Leu Asp Glu Ile Lys Glu Ala Ala Asn Ala Ala Asn 
        675                 680                 685             


Ile His Ser Phe Ile Glu Gly Leu Pro Glu Lys Tyr Asn Thr Gln Val 
    690                 695                 700                 


Gly Leu Lys Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala 
705                 710                 715                 720 


Ile Ala Arg Ala Leu Leu Gln Lys Pro Lys Ile Leu Leu Leu Asp Glu 
                725                 730                 735     


Ala Thr Ser Ala Leu Asp Asn Asp Ser Glu Lys Val Val Gln His Ala 
            740                 745                 750         


Leu Asp Lys Ala Arg Thr Gly Arg Thr Cys Leu Val Val Thr His Arg 
        755                 760                 765             


Leu Ser Ala Ile Gln Asn Ala Asp Leu Ile Val Val Leu His Asn Gly 
    770                 775                 780                 


Lys Ile Lys Glu Gln Gly Thr His Gln Glu Leu Leu Arg Asn Arg Asp 
785                 790                 795                 800 


Ile Tyr Phe Lys Leu Val Asn Ala Gln Ser Val Gln 
                805                 810         


<210>  16
<211>  2247
<212>  DNA
<213>  Homo sapiens

<400>  16
attgcttctc ggccttttgg ctaagatcaa gtgtaatctg tgttcttttt tatttggtca       60

tatcttccat tctttcttac ctaattcctc taatatctct ctgtgagcct aaaccaataa      120

ttatatatta cattctattg tctttcttat ataactgcag aaagataaat atcactttgt      180

ttgttcctgt aggttttctt tagtgtaatc catagcagtt attgcattgg agcagcagtc      240

cctcactttg aaaccttcgc aatagcccga ggagctgcct ttcatatttt ccaggttatt      300

gataagaaac ccagtataga taacttttcc acagctggat ataaacctga atccatagaa      360

ggaactgtgg aatttaaaaa tgtttctttc aattatccat caagaccatc tatcaagatt      420

ctgaaaggtc tgaatctcag aattaagtct ggagagacag tcgccttggt cggtctcaat      480

ggcagtggga agagtacggt agtccagctt ctgcagaggt tatatgatcc ggatgatggc      540

tttatcatgg tggatgagaa tgacatcaga gctttaaatg tgcggcatta tcgagaccat      600

attggagtgg ttagtcaaga gcctgttttg ttcgggacca ccatcagtaa caatatcaag      660

tatggacgag atgatgtgac tgatgaagag atggagagag cagcaaggga agcaaatgcg      720

tatgatttta tcatggagtt tcctaataaa tttaatacat tggtagggga aaaaggagct      780

caaatgagtg gagggcagaa acagaggatc gcaattgctc gtgccttagt tcgaaacccc      840

aagattctga ttttagatga ggctacgtct gccctggatt cagaaagcaa gtcagctgtt      900

caagctgcac tggagaagga tacccccagg tattcatttt gacctaattt cacctcaagt      960

ggagaatcgc tgaccttgaa ccagcgccct tcgacagctc tggcccctca aacctcaccc     1020

tgacctcctg ctgcctatga gctactgcac atacctcaag gccatatgca gttgtggccc     1080

tgcaccaaat tacactgaat ctaggagggg agttggcagt ggcggtatga aaaaccattg     1140

aacagttttc tcgatggcct gactccctta taaaccagag ccttcagacc ccttacaagg     1200

cttaatggca cattttactt tgcatttgct tggaagtgag ttaagcgttt ttttttctct     1260

aagaaaatcg caggcttctt tttttaaaat gctgacttta tggaaccaga aacggatact     1320

ggcaggctaa atgtccactg cttcttgaaa aatctcttag ttactattat ttagtagcaa     1380

atcagattgt gcaagtttga acgcttgttt ccctcccata ataacaatgc cacatgttgc     1440

ttgtgtgata aataatcttt gtttactgtg gacacttcgg caatttggtt catcttggta     1500

cagaaaatac aaagacagga ctaatatttt attcattttt tatacttagt aactaggaca     1560

gggatctgta tttagactat attcaagcct cgctctgtca cccatgcttg agtgcaacct     1620

ctgcccactg tgttcaagcg attctcctgc ctcagcctcc tgagtagctg ggagtacagg     1680

cgtgcatcac cacacccagc taatttttgt atttttagta gagacaaggt tttgccatgt     1740

tgaccaggct ggtctcaaac tcctgacctc aggtgatccg cccacctcgg cctcccaaag     1800

tgctgggatt acaggtgtgc gtctccgcgc ccggccagtt acataagatt ttaaaaaatg     1860

tattgtaata ggctctctga ttgtttagaa ggtttcatgt tgtgcccgca gtattttcat     1920

ccactggtaa tcactttagg taatcaaaac tagttcagac ttttaaaata aatagttgct     1980

tggtgacatg ataaactaat aaatgttatt cttattggtt aatatgaaac atctatcaaa     2040

agtgaaaaaa gaagaatgca gaatgtttgt aaactgattc caaaattaca caaaatagca     2100

actgtgaaaa aaatgaaggc aatatatgaa aataataaca gctatgtggc ataattatgg     2160

gggaatttaa cttatttcaa aaattcattt actgtccctg tttttcagtt gtttaaagga     2220

gaaagagatt aaatcaatgt agaaata                                         2247


<210>  17
<211>  5401
<212>  DNA
<213>  Homo sapiens

<400>  17
tgtagagaga gaaagagaaa acacgctcat gtaattgtgg tgactggcac ttccaaaatc       60

cacaagccag actagaaggc tggaaattct ggcaaaaaat tgataccttg tatctgaaag      120

ctttatccta tcctcttcag aagacttcag tcttttctct taaggacttc aactgactgg      180

atggggccca ctcaaaacag catctaagga attaaaaaga agtaaattgt aaataagatg      240

gaaaattcag aaagagctga agaaatgcaa gaaaattatc agagaaatgg aactgcagaa      300

gaacagccaa aactgagaaa ggaagcagtt ggatctattg agatattccg ctttgctgat      360

ggactggaca tcacactcat gatcctgggt atactggcat cactggtcaa tggagcctgc      420

cttcctttaa tgccactggt tttaggagaa atgagtgata accttattag tggatgtcta      480

gtccaaacta acacaacaaa ttatcagaac tgtactcagt ctcaagagaa gctgaatgaa      540

gatatgactc tgttgaccct gtattatgtt ggaataggtg ttgctgcctt gatttttggt      600

tacatacaga tttccttgtg gattataact gcagcacgac agaccaagag gattcgaaaa      660

cagttttttc attcagtttt ggcacaggac atcggctggt ttgatagctg tgacatcggt      720

gaacttaaca ctcgcatgac agatgacatt gacaaaatca gtgatggtat tggagataag      780

attgctctgt tgtttcaaaa catgtctact ttttcgattg gcctggcagt tggtttggtg      840

aagggctgga aactcaccct agtgactcta tccacgtctc ctcttataat ggcttcagcg      900

gcagcatgtt ctaggatggt catctcattg accagtaagg aattaagtgc ctattccaaa      960

gctggggctg tggcagaaga agtcttgtca tcaatccgaa cagtcatagc ctttagggcc     1020

caggagaaag aacttcaaag gtatacacag aatctcaaag atgcaaagga ttttggcata     1080

aaaaggacta tagcttcaaa agtgtctctt ggtgctgtgt acttctttat gaatggaacc     1140

tatggacttg ctttttggta tggaacctcc ttgattctta atggagaacc tggatatacc     1200

atcgggactg ttcttgctgt tttctttagt gtaatccata gcagttattg cattggagca     1260

gcagtccctc actttgaaac cttcgcaata gcccgaggag ctgcctttca tattttccag     1320

gttattgata agaaacccag tatagataac ttttccacag ctggatataa acctgaatcc     1380

atagaaggaa ctgtggaatt taaaaatgtt tctttcaatt atccatcaag accatctatc     1440

aagattctga aaggtctgaa tctcagaatt aagtctggag agacagtcgc cttggtcggt     1500

ctcaatggca gtgggaagag tacggtagtc cagcttctgc agaggttata tgatccggat     1560

gatggcttta tcatggtgga tgagaatgac atcagagctt taaatgtgcg gcattatcga     1620

gaccatattg gagtggttag tcaagagcct gttttgttcg ggaccaccat cagtaacaat     1680

atcaagtatg gacgagatga tgtgactgat gaagagatgg agagagcagc aagggaagca     1740

aatgcgtatg attttatcat ggagtttcct aataaattta atacattggt aggggaaaaa     1800

ggagctcaaa tgagtggagg gcagaaacag aggatcgcaa ttgctcgtgc cttagttcga     1860

aaccccaaga ttctgatttt agatgaggct acgtctgccc tggattcaga aagcaagtca     1920

gctgttcaag ctgcactgga gaaggcgagc aaaggtcgga ctacaatcgt ggtagcacac     1980

cgactttcta ctattcgaag tgcagatttg attgtgaccc taaaggatgg aatgctggcg     2040

gagaaaggag cacatgctga actaatggca aaacgaggtc tatattattc acttgtgatg     2100

tcacaggata ttaaaaaagc tgatgaacag atggagtcaa tgacatattc tactgaaaga     2160

aagaccaact cacttcctct gcactctgtg aagagcatca agtcagactt cattgacaag     2220

gctgaggaat ccacccaatc taaagagata agtcttcctg aagtctctct attaaaaatt     2280

ttaaagttaa acaagcctga atggcctttt gtggttctgg ggacattggc ttctgttcta     2340

aatggaactg ttcatccagt attttccatc atctttgcaa aaattataac catgtttgga     2400

aataatgata aaaccacatt aaagcatgat gcagaaattt attccatgat attcgtcatt     2460

ttgggtgtta tttgctttgt cagttatttc atgcagggat tattttacgg cagagcaggg     2520

gaaattttaa cgatgagatt aagacacttg gccttcaaag ccatgttata tcaggatatt     2580

gcctggtttg atgaaaagga aaacagcaca ggaggcttga caacaatatt agccatagat     2640

atagcacaaa ttcaaggagc aacaggttcc aggattggcg tcttaacaca aaatgcaact     2700

aacatgggac tttcagttat catttccttt atatatggat gggagatgac attcctgatt     2760

ctgagtattg ctccagtact tgccgtgaca ggaatgattg aaaccgcagc aatgactgga     2820

tttgccaaca aagataagca agaacttaag catgctggaa agatagcaac tgaagctttg     2880

gagaatatac gtactatagt gtcattaaca agggaaaaag ccttcgagca aatgtatgaa     2940

gagatgcttc agactcaaca cagaaatacc tcgaagaaag cacagattat tggaagctgt     3000

tatgcattca gccatgcctt tatatatttt gcctatgcgg cagggtttcg atttggagcc     3060

tatttaattc aagctggacg aatgacccca gagggcatgt tcatagtttt tactgcaatt     3120

gcatatggag ctatggccat cggagaaacg ctcgttttgg ctcctgaata ttccaaagcc     3180

aaatcggggg ctgcgcatct gtttgccttg ttggaaaaga aaccaaatat agacagccgc     3240

agtcaagaag ggaaaaagcc agacacatgt gaagggaatt tagagtttcg agaagtctct     3300

ttcttctatc catgtcgccc agatgttttc atcctccgtg gcttatccct cagtattgag     3360

cgaggaaaga cagtagcatt tgtggggagc agcggctgtg ggaaaagcac ttctgttcaa     3420

cttctgcaga gactttatga ccccgtgcaa ggacaagtgc tgtttgatgg tgtggatgca     3480

aaagaattga atgtacagtg gctccgttcc caaatagcaa tcgttcctca agagcctgtg     3540

ctcttcaact gcagcattgc tgagaacatc gcctatggtg acaacagccg tgtggtgcca     3600

ttagatgaga tcaaagaagc cgcaaatgca gcaaatatcc attcttttat tgaaggtctc     3660

cctgagaaat acaacacaca agttggactg aaaggagcac agctttctgg cggccagaaa     3720

caaagactag ctattgcaag ggctcttctc caaaaaccca aaattttatt gttggatgag     3780

gccacttcag ccctcgataa tgacagtgag aaggtggttc agcatgccct tgataaagcc     3840

aggacgggaa ggacatgcct agtggtcact cacaggctct ctgcaattca gaacgcagat     3900

ttgatagtgg ttctgcacaa tggaaagata aaggaacaag gaactcatca agagctcctg     3960

agaaatcgag acatatattt taagttagtg aatgcacagt cagtgcagtg atgctgttga     4020

ggtagcacat attttgatgt tcgtgtaatg caaagaagga gtacttaata attacttggc     4080

aagctttgat ctcttttatt gcatatatca atacctagaa tcatgctact caagtacata     4140

catgttctat tcacacacca tctgaccttc agatttttaa aaggaagcaa aaatttgctt     4200

atttcatgta agtgaaataa tgcttatatc cttcacttta taaaactatt ctagcacatt     4260

tgcttgtaaa gcagttttct acaaggtgaa tttatttccc atcaacttct gctataaaat     4320

cggaaatatg tttccagggg gaatattatc caattaacca tgttgaaggt tttagcaaag     4380

gcagtgtaag atagagtggg gcctgtagca ttgcagggag agtgtctttc acttggaatt     4440

ttgttttgca gcacatatta cagtagtttt gctagtccct tttctccaga ccgtagggat     4500

ttctctcaat aagtattcac tatttctcta aattttattc tatttttttg ttgagcaggg     4560

aatagaaagg attacgatgt aaaatttctg ggaggattag gtagctatct cctacttcac     4620

cagtaagtga agtgcctcac atgagccatc ccaaagattc attattccaa accttgggtt     4680

tggcagtata agtcacaggc ctacctgttt atgaaaactt acttacttaa aataagagct     4740

acttttgggc cgggtgcggt ggctcacgcc tgtaatccca gaactttggg aggccgagga     4800

gggcggatca cttgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccgt     4860

ctctactaaa aacacaaaaa ttagccaatc ttggtggcgg gcacctggaa tcccagctac     4920

ttgggaggct gaggcaggag aatcatttga acctaggagg cagaggttgc agtgagccga     4980

gatctcacca ctgcactcca gcctgcgcaa cagagcgaga ctccatctca aaaaataata     5040

aataagagct aattttattg tgggtgaaaa tttttaaacg tctttctcta taataaaata     5100

atttccttaa attttatata tactttatca tatataatgt gtgaatgatt ttaaagttct     5160

gtgtaaataa caatattggt aaaatgagtt acattttcaa cttacttaaa tatgtaatgt     5220

cacctggtga ttttatcttt attcttcagt gtattttctt ccatttacac atttagctag     5280

cctccctaaa gtgtactcta ccaataattg aaatcttgtt aaacaaaatt aaaaccattt     5340

atatattatg ctgctttctt taaaatgcaa aataaaaata agattgggga cttgagaatc     5400

a                                                                     5401


<210>  18
<211>  4375
<212>  DNA
<213>  Homo sapiens

<400>  18
attgcttctc ggccttttgg ctaagatcaa gtgtaatctg tgttcttttt tatttggtca       60

tatcttccat tctttcttac ctaattcctc taatatctct ctgtgagcct aaaccaataa      120

ttatatatta cattctattg tctttcttat ataactgcag aaagataaat atcactttgt      180

ttgttcctgt aggttttctt tagtgtaatc catagcagtt attgcattgg agcagcagtc      240

cctcactttg aaaccttcgc aatagcccga ggagctgcct ttcatatttt ccaggttatt      300

gataagaaac ccagtataga taacttttcc acagctggat ataaacctga atccatagaa      360

ggaactgtgg aatttaaaaa tgtttctttc aattatccat caagaccatc tatcaagatt      420

ctgaaaggtc tgaatctcag aattaagtct ggagagacag tcgccttggt cggtctcaat      480

ggcagtggga agagtacggt agtccagctt ctgcagaggt tatatgatcc ggatgatggc      540

tttatcatgg tggatgagaa tgacatcaga gctttaaatg tgcggcatta tcgagaccat      600

attggagtgg ttagtcaaga gcctgttttg ttcgggacca ccatcagtaa caatatcaag      660

tatggacgag atgatgtgac tgatgaagag atggagagag cagcaaggga agcaaatgcg      720

tatgatttta tcatggagtt tcctaataaa tttaatacat tggtagggga aaaaggagct      780

caaatgagtg gagggcagaa acagaggatc gcaattgctc gtgccttagt tcgaaacccc      840

aagattctga ttttagatga ggctacgtct gccctggatt cagaaagcaa gtcagctgtt      900

caagctgcac tggagaaggc gagcaaaggt cggactacaa tcgtggtagc acaccgactt      960

tctactattc gaagtgcaga tttgattgtg accctaaagg atggaatgct ggcggagaaa     1020

ggagcacatg ctgaactaat ggcaaaacga ggtctatatt attcacttgt gatgtcacag     1080

gatattaaaa aagctgatga acagatggag tcaatgacat attctactga aagaaagacc     1140

aactcacttc ctctgcactc tgtgaagagc atcaagtcag acttcattga caaggctgag     1200

gaatccaccc aatctaaaga gataagtctt cctgaagtct ctctattaaa aattttaaag     1260

ttaaacaagc ctgaatggcc ttttgtggtt ctggggacat tggcttctgt tctaaatgga     1320

actgttcatc cagtattttc catcatcttt gcaaaaatta taaccatgtt tggaaataat     1380

gataaaacca cattaaagca tgatgcagaa atttattcca tgatattcgt cattttgggt     1440

gttatttgct ttgtcagtta tttcatgcag ggattatttt acggcagagc aggggaaatt     1500

ttaacgatga gattaagaca cttggccttc aaagccatgt tatatcagga tattgcctgg     1560

tttgatgaaa aggaaaacag cacaggaggc ttgacaacaa tattagccat agatatagca     1620

caaattcaag gagcaacagg ttccaggatt ggcgtcttaa cacaaaatgc aactaacatg     1680

ggactttcag ttatcatttc ctttatatat ggatgggaga tgacattcct gattctgagt     1740

attgctccag tacttgccgt gacaggaatg attgaaaccg cagcaatgac tggatttgcc     1800

aacaaagata agcaagaact taagcatgct ggaaagatag caactgaagc tttggagaat     1860

atacgtacta tagtgtcatt aacaagggaa aaagccttcg agcaaatgta tgaagagatg     1920

cttcagactc aacacagaaa tacctcgaag aaagcacaga ttattggaag ctgttatgca     1980

ttcagccatg cctttatata ttttgcctat gcggcagggt ttcgatttgg agcctattta     2040

attcaagctg gacgaatgac cccagagggc atgttcatag tttttactgc aattgcatat     2100

ggagctatgg ccatcggaga aacgctcgtt ttggctcctg aatattccaa agccaaatcg     2160

ggggctgcgc atctgtttgc cttgttggaa aagaaaccaa atatagacag ccgcagtcaa     2220

gaagggaaaa agccagacac atgtgaaggg aatttagagt ttcgagaagt ctctttcttc     2280

tatccatgtc gcccagatgt tttcatcctc cgtggcttat ccctcagtat tgagcgagga     2340

aagacagtag catttgtggg gagcagcggc tgtgggaaaa gcacttctgt tcaacttctg     2400

cagagacttt atgaccccgt gcaaggacaa gtgctgtttg atggtgtgga tgcaaaagaa     2460

ttgaatgtac agtggctccg ttcccaaata gcaatcgttc ctcaagagcc tgtgctcttc     2520

aactgcagca ttgctgagaa catcgcctat ggtgacaaca gccgtgtggt gccattagat     2580

gagatcaaag aagccgcaaa tgcagcaaat atccattctt ttattgaagg tctccctgag     2640

aaatacaaca cacaagttgg actgaaagga gcacagcttt ctggcggcca gaaacaaaga     2700

ctagctattg caagggctct tctccaaaaa cccaaaattt tattgttgga tgaggccact     2760

tcagccctcg ataatgacag tgagaaggtg gttcagcatg cccttgataa agccaggacg     2820

ggaaggacat gcctagtggt cactcacagg ctctctgcaa ttcagaacgc agatttgata     2880

gtggttctgc acaatggaaa gataaaggaa caaggaactc atcaagagct cctgagaaat     2940

cgagacatat attttaagtt agtgaatgca cagtcagtgc agtgatgctg ttgaggtagc     3000

acatattttg atgttcgtgt aatgcaaaga aggagtactt aataattact tggcaagctt     3060

tgatctcttt tattgcatat atcaatacct agaatcatgc tactcaagta catacatgtt     3120

ctattcacac accatctgac cttcagattt ttaaaaggaa gcaaaaattt gcttatttca     3180

tgtaagtgaa ataatgctta tatccttcac tttataaaac tattctagca catttgcttg     3240

taaagcagtt ttctacaagg tgaatttatt tcccatcaac ttctgctata aaatcggaaa     3300

tatgtttcca gggggaatat tatccaatta accatgttga aggttttagc aaaggcagtg     3360

taagatagag tggggcctgt agcattgcag ggagagtgtc tttcacttgg aattttgttt     3420

tgcagcacat attacagtag ttttgctagt cccttttctc cagaccgtag ggatttctct     3480

caataagtat tcactatttc tctaaatttt attctatttt tttgttgagc agggaataga     3540

aaggattacg atgtaaaatt tctgggagga ttaggtagct atctcctact tcaccagtaa     3600

gtgaagtgcc tcacatgagc catcccaaag attcattatt ccaaaccttg ggtttggcag     3660

tataagtcac aggcctacct gtttatgaaa acttacttac ttaaaataag agctactttt     3720

gggccgggtg cggtggctca cgcctgtaat cccagaactt tgggaggccg aggagggcgg     3780

atcacttgag gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ccgtctctac     3840

taaaaacaca aaaattagcc aatcttggtg gcgggcacct ggaatcccag ctacttggga     3900

ggctgaggca ggagaatcat ttgaacctag gaggcagagg ttgcagtgag ccgagatctc     3960

accactgcac tccagcctgc gcaacagagc gagactccat ctcaaaaaat aataaataag     4020

agctaatttt attgtgggtg aaaattttta aacgtctttc tctataataa aataatttcc     4080

ttaaatttta tatatacttt atcatatata atgtgtgaat gattttaaag ttctgtgtaa     4140

ataacaatat tggtaaaatg agttacattt tcaacttact taaatatgta atgtcacctg     4200

gtgattttat ctttattctt cagtgtattt tcttccattt acacatttag ctagcctccc     4260

taaagtgtac tctaccaata attgaaatct tgttaaacaa aattaaaacc atttatatat     4320

tatgctgctt tctttaaaat gcaaaataaa aataagattg gggacttgag aatca          4375


<210>  19
<211>  1724
<212>  DNA
<213>  Homo sapiens

<400>  19
attgcttctc ggccttttgg ctaagatcaa gtgtaatctg tgttcttttt tatttggtca       60

tatcttccat tctttcttac ctaattcctc taatatctct ctgtgagcct aaaccaataa      120

ttatatatta cattctattg tctttcttat ataactgcag aaagataaat atcactttgt      180

ttgttcctgt aggttttctt tagtgtaatc catagcagtt attgcattgg agcagcagtc      240

cctcactttg aaaccttcgc aatagcccga ggagctgcct ttcatatttt ccaggttatt      300

gataagaaac ccagtataga taacttttcc acagctggat ataaacctga atccatagaa      360

ggaactgtgg aatttaaaaa tgtttctttc aattatccat caagaccatc tatcaagatt      420

ctgaaaggtc tgaatctcag aattaagtct ggagagacag tcgccttggt cggtctcaat      480

ggcagtggga agagtacggt agtccagctt ctgcagaggt tatatgatcc ggatgatggc      540

tttatcatgg tggatgagaa tgacatcaga gctttaaatg tgcggcatta tcgagaccat      600

attggagtgg ttagtcaaga gcctgttttg ttcgggacca ccatcagtaa caatatcaag      660

tatggacgag atgatgtgac tgatgaagag atggagagag cagcaaggga agcaaatgcg      720

tatgatttta tcatggagtt tcctaataaa tttaatacat tggtagggga aaaaggagct      780

caaatgagtg gagggcagaa acagaggatc gcaattgctc gtgccttagt tcgaaacccc      840

aagattctga ttttagatga ggctacgtct gccctggatt cagaaagcaa gtcagctgtt      900

caagctgcac tggagaagaa aaaataatac aacaaagacg tattgataat ctaccacact      960

atctacgttg aggtatctgg aaccacagtg gtatgaattg cactatctcc ctaatcttta     1020

cactaattct ggctaaaaga cagcatcagc tcaaattttc ctgatcagtt ttttagcagg     1080

ctttggctgc caaaatctct tctgtgtttt aagtctgaag caattacagt tgaatatttt     1140

gttgttgttc actatgagga gtatatcggt tttaggtcac atgaatgatc tagtagagat     1200

gtatttttct agtacacttg atagtacctt gaatatgtac agtacatgta ggcccatttt     1260

atggacctct gaggcacagt tttttccctt ttaagttatt agatatttct gtgatttatt     1320

tgatgcactc agatacaaat tcatgctata ataagttaaa ttgtaacata atatctacct     1380

taatcaaata tttatagttt aggccaggag cctggcaaag taaagatgac acagatgaaa     1440

tgcttgataa gtaaataaat atgagaagag atatatatta aaacacctgt gaagtgaatc     1500

ccctgtgaag aaaagaaggt ctctaacaat ataaacctgt atcaggaaac cctgtgattc     1560

tgattctgtg cacagaagga tacatggaat tctcagacct tttctagttg caacctttta     1620

attgtttgac tttatattct gtcctctcaa attctcctta gactgtgacg tgttaatgct     1680

ctcttttata ttttctaatt aaattccata cacattaatt tgag                      1724


<210>  20
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  20

Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His 
1               5                   10                  15      


Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser 
            20                  25                  30          


Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His 
        35                  40                  45              


Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met 
    50                  55                  60                  


Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr 
65                  70                  75                  80  


Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys 
                85                  90                  95      


Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys 
            100                 105                 110         


Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp 
        115                 120                 125             


Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val 
    130                 135                 140                 


Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile 
145                 150                 155                 160 


Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr 
                165                 170                 175     


Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly 
            180                 185                 190         


Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr 
        195                 200                 205             


Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe 
    210                 215                 220                 


Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met 
225                 230                 235                 240 


Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp 
                245                 250                 255     


Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp 
            260                 265                 270         


Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu 
        275                 280                 285             


Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys 
    290                 295                 300                 


Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu 
305                 310                 315                 320 


Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala 
                325                 330                 335     


Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg 
            340                 345                 350         


Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys 
        355                 360                 365             


Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala 
    370                 375                 380                 


Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn 
385                 390                 395                 400 


Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr 
                405                 410                 415     


Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp 
            420                 425                 430         


Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile 
        435                 440                 445             


Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro 
    450                 455                 460                 


Ala Asn Ser Ile Leu Trp Cys 
465                 470     


<210>  21
<211>  2735
<212>  DNA
<213>  Homo sapiens

<400>  21
acaacagtcc ccaggcatca ccattcaaga tgcatccagg ggtcctggct gccttcctct       60

tcttgagctg gactcattgt cgggccctgc cccttcccag tggtggtgat gaagatgatt      120

tgtctgagga agacctccag tttgcagagc gctacctgag atcatactac catcctacaa      180

atctcgcggg aatcctgaag gagaatgcag caagctccat gactgagagg ctccgagaaa      240

tgcagtcttt cttcggctta gaggtgactg gcaaacttga cgataacacc ttagatgtca      300

tgaaaaagcc aagatgcggg gttcctgatg tgggtgaata caatgttttc cctcgaactc      360

ttaaatggtc caaaatgaat ttaacctaca gaattgtgaa ttacacccct gatatgactc      420

attctgaagt cgaaaaggca ttcaaaaaag ccttcaaagt ttggtccgat gtaactcctc      480

tgaattttac cagacttcac gatggcattg ctgacatcat gatctctttt ggaattaagg      540

agcatggcga cttctaccca tttgatgggc cctctggcct gctggctcat gcttttcctc      600

ctgggccaaa ttatggagga gatgcccatt ttgatgatga tgaaacctgg acaagtagtt      660

ccaaaggcta caacttgttt cttgttgctg cgcatgagtt cggccactcc ttaggtcttg      720

accactccaa ggaccctgga gcactcatgt ttcctatcta cacctacacc ggcaaaagcc      780

actttatgct tcctgatgac gatgtacaag ggatccagtc tctctatggt ccaggagatg      840

aagaccccaa ccctaaacat ccaaaaacgc cagacaaatg tgacccttcc ttatcccttg      900

atgccattac cagtctccga ggagaaacaa tgatctttaa agacagattc ttctggcgcc      960

tgcatcctca gcaggttgat gcggagctgt ttttaacgaa atcattttgg ccagaacttc     1020

ccaaccgtat tgatgctgca tatgagcacc cttctcatga cctcatcttc atcttcagag     1080

gtagaaaatt ttgggctctt aatggttatg acattctgga aggttatccc aaaaaaatat     1140

ctgaactggg tcttccaaaa gaagttaaga agataagtgc agctgttcac tttgaggata     1200

caggcaagac tctcctgttc tcaggaaacc aggtctggag atatgatgat actaaccata     1260

ttatggataa agactatccg agactaatag aagaagactt cccaggaatt ggtgataaag     1320

tagatgctgt ctatgagaaa aatggttata tctatttttt caacggaccc atacagtttg     1380

aatacagcat ctggagtaac cgtattgttc gcgtcatgcc agcaaattcc attttgtggt     1440

gttaagtgtc tttttaaaaa ttgttattta aatcctgaag agcatttggg gtaatacttc     1500

cagaagtgcg gggtagggga agaagagcta tcaggagaaa gcttggttct gtgaacaagc     1560

ttcagtaagt tatctttgaa tatgtagtat ctatatgact atgcgtggct ggaaccacat     1620

tgaagaatgt tagagtaatg aaatggagga tctctaaaga gcatctgatt cttgttgctg     1680

tacaaaagca atggttgatg atacttccca caccacaaat gggacacatg gtctgtcaat     1740

gagagcataa tttaaaaata tatttataag gaaattttac aagggcataa agtaaataca     1800

tgcatataat gaataaatca ttcttactaa aaagtataaa atagtatgaa aatggaaatt     1860

tgggagagcc atacataaaa gaaataaacc aaaggaaaat gtctgtaata atagactgta     1920

acttccaaat aaataatttt cattttgcac tgaggatatt cagatgtatg tgcccttctt     1980

cacacagaca ctaacgaaat atcaaagtca ttaaagacag gagacaaaag agcagtggta     2040

agaatagtag atgtggcctt tgaattctgt ttaattttca cttttggcaa tgactcaaag     2100

tctgctctca tataagacaa atattccttt gcatattata aaggataaag aaggatgatg     2160

tctttttatt aaaatatttc aggttcttca gaagtcacac attacaaagt taaaattgtt     2220

atcaaaatag tctaaggcca tggcatccct ttttcataaa ttatttgatt atttaagact     2280

aaaagttgca ttttaaccct attttaccta gctaattatt taattgtcca gtttgtcttg     2340

gatatatagg ctattttcta aagacttgta tagcatgaaa taaaatatat cttataaagt     2400

ggaagtatgt atattaaaaa agagacatcc aaattttttt ttaaagcagt ctactagatt     2460

gtgatccctt gagatatgga aggatgcctt tttttctctg catttaaaaa aatcccccag     2520

cacttcccac agtgcctatt gatacttggg gagggtgctt ggcacttatt gaatatatga     2580

tcggccatca agggaagaac tattgtgctc agagacactg ttgataaaaa ctcaggcaaa     2640

gaaaatgaaa tgcatatttg caaagtgtat taggaagtgt ttatgttgtt tataataaaa     2700

atatattttc aacagacaaa aaaaaaaaaa aaaaa                                2735


<210>  22
<211>  1261
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Gly Ser Lys Ser Val Ser Pro Pro Gly Tyr Ala Ala Gln Lys 
1               5                   10                  15      


Thr Ala Ala Pro Ala Pro Arg Gly Gly Pro Glu His Arg Ser Ala Trp 
            20                  25                  30          


Gly Glu Ala Asp Ser Arg Ala Asn Gly Tyr Pro His Ala Pro Gly Gly 
        35                  40                  45              


Ser Ala Arg Gly Ser Thr Lys Lys Pro Gly Gly Ala Val Thr Pro Gln 
    50                  55                  60                  


Gln Gln Gln Arg Leu Ala Ser Arg Trp Arg Ser Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Pro Pro Leu Ser Gly Asp Asp Pro Leu Ala Gly Gly Phe Gly Phe Ser 
                85                  90                  95      


Phe Arg Ser Lys Ser Ala Trp Gln Glu Arg Gly Gly Asp Asp Cys Gly 
            100                 105                 110         


Arg Gly Ser Arg Arg Gln Arg Arg Gly Ala Ala Ser Gly Gly Ser Thr 
        115                 120                 125             


Arg Ala Pro Pro Ala Gly Gly Gly Gly Gly Ser Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ser Ala Gly Gly Thr Glu Val Arg Pro Arg Ser Val Glu Val Gly Leu 
145                 150                 155                 160 


Glu Glu Arg Arg Gly Lys Gly Arg Ala Ala Asp Glu Leu Glu Ala Gly 
                165                 170                 175     


Ala Val Glu Gly Gly Glu Gly Ser Gly Asp Gly Gly Ser Ser Ala Asp 
            180                 185                 190         


Ser Gly Ser Gly Ala Gly Pro Gly Ala Val Leu Ser Leu Gly Ala Cys 
        195                 200                 205             


Cys Leu Ala Leu Leu Gln Ile Phe Arg Ser Lys Lys Phe Pro Ser Asp 
    210                 215                 220                 


Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Arg Leu Asn Gln Ser 
225                 230                 235                 240 


Ser Leu Thr Met Leu Met Ala Val Leu Val Leu Val Cys Leu Val Met 
                245                 250                 255     


Leu Ala Phe His Ala Ala Arg Pro Pro Leu Gln Leu Pro Tyr Leu Ala 
            260                 265                 270         


Val Leu Ala Ala Ala Val Gly Val Ile Leu Ile Met Ala Val Leu Cys 
        275                 280                 285             


Asn Arg Ala Ala Phe His Gln Asp His Met Gly Leu Ala Cys Tyr Ala 
    290                 295                 300                 


Leu Ile Ala Val Val Leu Ala Val Gln Val Val Gly Leu Leu Leu Pro 
305                 310                 315                 320 


Gln Pro Arg Ser Ala Ser Glu Gly Ile Trp Trp Thr Val Phe Phe Ile 
                325                 330                 335     


Tyr Thr Ile Tyr Thr Leu Leu Pro Val Arg Met Arg Ala Ala Val Leu 
            340                 345                 350         


Ser Gly Val Leu Leu Ser Ala Leu His Leu Ala Ile Ala Leu Arg Thr 
        355                 360                 365             


Asn Ala Gln Asp Gln Phe Leu Leu Lys Gln Leu Val Ser Asn Val Leu 
    370                 375                 380                 


Ile Phe Ser Cys Thr Asn Ile Val Gly Val Cys Thr His Tyr Pro Ala 
385                 390                 395                 400 


Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Glu Cys Ile Gln 
                405                 410                 415     


Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg Leu Leu 
            420                 425                 430         


Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala Asp Ile 
        435                 440                 445             


Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln Lys 
    450                 455                 460                 


His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Thr Ser 
465                 470                 475                 480 


Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu Asn Glu 
                485                 490                 495     


Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu Arg 
            500                 505                 510         


Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Glu 
        515                 520                 525             


Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met Asp Met 
    530                 535                 540                 


Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn Val Asn 
545                 550                 555                 560 


Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu Gly 
                565                 570                 575     


Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr Leu Ala 
            580                 585                 590         


Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile Thr Lys 
        595                 600                 605             


Ala Thr Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly Cys 
    610                 615                 620                 


Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu Thr Phe 
625                 630                 635                 640 


Leu Ile Leu Arg Cys Thr Gln Lys Arg Lys Glu Glu Lys Ala Met Ile 
                645                 650                 655     


Ala Lys Met Asn Arg Gln Arg Thr Asn Ser Ile Gly His Asn Pro Pro 
            660                 665                 670         


His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly Asn Gln 
        675                 680                 685             


Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys Asp Lys 
    690                 695                 700                 


Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu Phe Leu 
705                 710                 715                 720 


Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser Glu His 
                725                 730                 735     


Val Arg Lys Phe Leu Leu Thr Phe Arg Glu Pro Asp Leu Glu Lys Lys 
            740                 745                 750         


Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala Cys Ala 
        755                 760                 765             


Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Thr Ile Val Pro 
    770                 775                 780                 


His Ser Ile Phe Met Leu Ser Phe Tyr Leu Thr Cys Ser Leu Leu Leu 
785                 790                 795                 800 


Thr Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys Leu Phe 
                805                 810                 815     


Pro Ser Pro Leu Gln Thr Leu Ser Arg Lys Ile Val Arg Ser Lys Met 
            820                 825                 830         


Asn Ser Thr Leu Val Gly Val Phe Thr Ile Thr Leu Val Phe Leu Ala 
        835                 840                 845             


Ala Phe Val Asn Met Phe Thr Cys Asn Ser Arg Asp Leu Leu Gly Cys 
    850                 855                 860                 


Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala Cys His 
865                 870                 875                 880 


Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln Gly Phe 
                885                 890                 895     


Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe Thr Tyr 
            900                 905                 910         


Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln Ile Ser 
        915                 920                 925             


Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile Tyr Val 
    930                 935                 940                 


Leu Ile Val Glu Val Pro Gly Val Thr Leu Phe Asp Asn Ala Asp Leu 
945                 950                 955                 960 


Leu Val Thr Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Thr Ser Gln 
                965                 970                 975     


Cys Pro Glu His Ala Thr Lys Val Ala Leu Lys Val Val Thr Pro Ile 
            980                 985                 990         


Ile Ile Ser Val Phe Val Leu Ala  Leu Tyr Leu His Ala  Gln Gln Val 
        995                 1000                 1005             


Glu Ser  Thr Ala Arg Leu Asp  Phe Leu Trp Lys Leu  Gln Ala Thr 
    1010                 1015                 1020             


Glu Glu  Lys Glu Glu Met Glu  Glu Leu Gln Ala Tyr  Asn Arg Arg 
    1025                 1030                 1035             


Leu Leu  His Asn Ile Leu Pro  Lys Asp Val Ala Ala  His Phe Leu 
    1040                 1045                 1050             


Ala Arg  Glu Arg Arg Asn Asp  Glu Leu Tyr Tyr Gln  Ser Cys Glu 
    1055                 1060                 1065             


Cys Val  Ala Val Met Phe Ala  Ser Ile Ala Asn Phe  Ser Glu Phe 
    1070                 1075                 1080             


Tyr Val  Glu Leu Glu Ala Asn  Asn Glu Gly Val Glu  Cys Leu Arg 
    1085                 1090                 1095             


Leu Leu  Asn Glu Ile Ile Ala  Asp Phe Asp Glu Ile  Ile Ser Glu 
    1100                 1105                 1110             


Asp Arg  Phe Arg Gln Leu Glu  Lys Ile Lys Thr Ile  Gly Ser Thr 
    1115                 1120                 1125             


Tyr Met  Ala Ala Ser Gly Leu  Asn Asp Ser Thr Tyr  Asp Lys Val 
    1130                 1135                 1140             


Gly Lys  Thr His Ile Lys Ala  Leu Ala Asp Phe Ala  Met Lys Leu 
    1145                 1150                 1155             


Met Asp  Gln Met Lys Tyr Ile  Asn Glu His Ser Phe  Asn Asn Phe 
    1160                 1165                 1170             


Gln Met  Lys Ile Gly Leu Asn  Ile Gly Pro Val Val  Ala Gly Val 
    1175                 1180                 1185             


Ile Gly  Ala Arg Lys Pro Gln  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1190                 1195                 1200             


Asn Val  Ala Ser Arg Met Asp  Ser Thr Gly Val Pro  Asp Arg Ile 
    1205                 1210                 1215             


Gln Val  Thr Thr Asp Met Tyr  Gln Val Leu Ala Ala  Asn Thr Tyr 
    1220                 1225                 1230             


Gln Leu  Glu Cys Arg Gly Val  Val Lys Val Lys Gly  Lys Gly Glu 
    1235                 1240                 1245             


Met Met  Thr Tyr Phe Leu Asn  Gly Gly Pro Pro Leu  Ser 
    1250                 1255                 1260     


<210>  23
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys Ser Gln Lys Glu Gly Cys Cys Ser Arg Gly Asp Leu Ser Ile 
1               5                   10                  15      


Gln Thr Gly Pro Gly Gly Glu Trp Ala Pro Arg Arg Leu Val Ser Asn 
            20                  25                  30          


Val Leu Ile Phe Ser Cys Thr Asn Ile Val Gly Val Cys Thr His Tyr 
        35                  40                  45              


Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Glu Cys 
    50                  55                  60                  


Ile Gln Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg 
65                  70                  75                  80  


Leu Leu Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala 
                85                  90                  95      


Asp Ile Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile 
            100                 105                 110         


Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe 
        115                 120                 125             


Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu 
    130                 135                 140                 


Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys 
145                 150                 155                 160 


Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                165                 170                 175     


Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met 
            180                 185                 190         


Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn 
        195                 200                 205             


Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val 
    210                 215                 220                 


Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr 
225                 230                 235                 240 


Leu Ala Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile 
                245                 250                 255     


Thr Lys Ala Thr Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro 
            260                 265                 270         


Gly Cys Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu 
        275                 280                 285             


Thr Phe Leu Ile Leu Arg Cys Thr Gln Lys Arg Lys Glu Glu Lys Ala 
    290                 295                 300                 


Met Ile Ala Lys Met Asn Arg Gln Arg Thr Asn Ser Ile Gly His Asn 
305                 310                 315                 320 


Pro Pro His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly 
                325                 330                 335     


Asn Gln Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys 
            340                 345                 350         


Asp Lys Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu 
        355                 360                 365             


Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser 
    370                 375                 380                 


Glu His Val Arg Lys Phe Leu Leu Thr Phe Arg Glu Pro Asp Leu Glu 
385                 390                 395                 400 


Lys Lys Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala 
                405                 410                 415     


Cys Ala Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Thr Ile 
            420                 425                 430         


Val Pro His Ser Ile Phe Met Leu Ser Phe Tyr Leu Thr Cys Ser Leu 
        435                 440                 445             


Leu Leu Thr Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys 
    450                 455                 460                 


Leu Phe Pro Ser Pro Leu Gln Thr Leu Ser Arg Lys Ile Val Arg Ser 
465                 470                 475                 480 


Lys Met Asn Ser Thr Leu Val Gly Val Phe Thr Ile Thr Leu Val Phe 
                485                 490                 495     


Leu Ala Ala Phe Val Asn Met Phe Thr Cys Asn Ser Arg Asp Leu Leu 
            500                 505                 510         


Gly Cys Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala 
        515                 520                 525             


Cys His Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln 
    530                 535                 540                 


Gly Phe Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe 
545                 550                 555                 560 


Thr Tyr Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln 
                565                 570                 575     


Ile Ser Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile 
            580                 585                 590         


Tyr Val Leu Ile Val Glu Val Pro Gly Val Thr Leu Phe Asp Asn Ala 
        595                 600                 605             


Asp Leu Leu Val Thr Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Thr 
    610                 615                 620                 


Ser Gln Cys Pro Glu His Ala Thr Lys Val Ala Leu Lys Val Val Thr 
625                 630                 635                 640 


Pro Ile Ile Ile Ser Val Phe Val Leu Ala Leu Tyr Leu His Ala Gln 
                645                 650                 655     


Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
            660                 665                 670         


Thr Glu Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
        675                 680                 685             


Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
    690                 695                 700                 


Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
705                 710                 715                 720 


Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
                725                 730                 735     


Leu Glu Ala Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu Asn Glu 
            740                 745                 750         


Ile Ile Ala Asp Phe Asp Glu Ile Ile Ser Glu Asp Arg Phe Arg Gln 
        755                 760                 765             


Leu Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly 
    770                 775                 780                 


Leu Asn Asp Ser Thr Tyr Asp Lys Val Gly Lys Thr His Ile Lys Ala 
785                 790                 795                 800 


Leu Ala Asp Phe Ala Met Lys Leu Met Asp Gln Met Lys Tyr Ile Asn 
                805                 810                 815     


Glu His Ser Phe Asn Asn Phe Gln Met Lys Ile Gly Leu Asn Ile Gly 
            820                 825                 830         


Pro Val Val Ala Gly Val Ile Gly Ala Arg Lys Pro Gln Tyr Asp Ile 
        835                 840                 845             


Trp Gly Asn Thr Val Asn Val Ala Ser Arg Met Asp Ser Thr Gly Val 
    850                 855                 860                 


Pro Asp Arg Ile Gln Val Thr Thr Asp Met Tyr Gln Val Leu Ala Ala 
865                 870                 875                 880 


Asn Thr Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys Gly Lys 
                885                 890                 895     


Gly Glu Met Met Thr Tyr Phe Leu Asn Gly Gly Pro Pro Leu Ser 
            900                 905                 910     


<210>  24
<211>  3326
<212>  DNA
<213>  Homo sapiens

<400>  24
gccacgctgt cctccctcct ccgctccctg cgccccaccc ctggcggccg cgctgcctgg       60

cagcccggga agccgcggca cagctgctcg gcgcctgcag ctccggctcg ggggctggaa      120

ccgaagcggg ggcggcggga gcgcggagac cacagccccc ggggagaggc ggagggggtc      180

cctggcctgg gcggagaggc tgagctgagt gcgcgtgaga aagagggctg caccgctgct      240

cggcgcggac tctgccagcc ccagcttcag ccccggctca ggtcgccgca gcccgggagc      300

ctccccgctt gcgccccaag gcacgcgcgg cacagccatg aacaccaacg atgccaagga      360

gtatctggcc cggagggaaa tccctcagct ttttgagagc cttttgaatg gactgatgtg      420

ttctaagccc gaagatccag tagaatactt ggaaagttgt ttacaaaaag taaaggaact      480

gggtggctgt gacaaggtga aatgggatac atttgtaagc caggaaaaga agaccttacc      540

tccactaaat ggaggacagt cacggagatc ctttctaaga aatgtaatgc ctgaaaactc      600

aaactttcca tatcggcggt atgaccggct ccctccaatc catcaattct ccatagaaag      660

tgacacggat ctctctgaga ctgcagagtt gattgaggag tatgaggttt ttgatcctac      720

cagacctcga ccaaaaatca ttcttgttat aggtggtcca ggaagtggaa agggtactca      780

gagtttgaaa attgcagaac gatatggatt ccaatacatt tctgtgggag aattattaag      840

aaagaagatc cacagtacca gcagcaatag gaaatggagt cttattgcca agataattac      900

aactggagaa ttggccccac aggaaacaac aattacagag ataaaacaaa aattgatgca      960

aatacctgat gaagagggca ttgttattga tggatttcca agagatgttg cccaggctct     1020

atcttttgag gaccaaatct gtacccccga tttggtggta ttcctggctt gtgctaatca     1080

gagactcaaa gaaagattac tgaagcgtgc agaacagcag ggccgaccag acgacaatgt     1140

aaaagctacc caaaggagac taatgaactt caagcagaat gctgctccat tggttaaata     1200

cttccaggaa aaggggctca tcatgacatt tgatgccgac cgcgatgagg atgaggtgtt     1260

ctatgacatc agcatggcag ttgacaacaa gttatttcca aacaaagagg ctgcagcagg     1320

ttcaagtgac cttgatcctt cgatgatatt ggacactgga gagatcattg atacaggatc     1380

tgattatgaa gatcagggtg atgaccagtt aaatgtattt ggagaggaca ctatgggagg     1440

tttcatggaa gatttgagaa agtgtaaaat tattttcata attggtggtc ctggctctgg     1500

caaaggcaca cagtgtgaaa agctggtgga aaaatatgga tttacacatc tctcaactgg     1560

cgagctcctg cgtgaggaac tggcatcaga atctgaaaga agcaaattga tcagagacat     1620

tatggaacgt ggagacctgg tgccctcagg catcgttttg gagctcctga aggaggccat     1680

ggtggccagc ctcggggaca ccaggggctt cctgattgac ggctatcctc gggaggtgaa     1740

gcaaggggaa gagttcggac gcaggattgg agacccacag ttggtgatct gtatggactg     1800

ctcggcagac accatgacca accgccttct ccaaaggagc cggagcagcc tgcctgtgga     1860

cgacaccacc aagaccatcg ccaagcgcct agaagcctac taccgagcgt ccatccccgt     1920

gatcgcctac tacgagacaa aaacacagct acacaagata aatgcagagg gaacaccaga     1980

ggacgttttt cttcaactct gcacagctat tgactctatt ttctgaaggc aaaaatgcat     2040

gtttgttaga atggaaacag aaaaacatta aaaagttcat tccttaacac aatgtttcaa     2100

gttaaacctt ttgtgtcacc gcccccacca accaccacct cctaaatcct gacagcactg     2160

tttgcttccc agctagacct gtgtgagagg tgtctggaaa tcatgcatgg tgtatttggg     2220

actatatcaa cctattctcc acacttcaga caactgtctg cactcacggc acacacactt     2280

tgtatcatgc aggccacact cagagctagt cagtacatga acagtggtgc ggtgccagtc     2340

tgtgtccgtt gtgatcacag gccttgctag accctgatca tctggttctc ctctcattaa     2400

gcatccctaa cccccagtca caccttcctc ttacatactg ttccccaatg gaggcccctg     2460

gcatagggga cagccctggg catcttcctt tggtgtctgg ctgttttgtc aactctcatc     2520

cactggtggc tcagagccat aaggtgggtt gattacacaa tgccttgtac atgatataga     2580

ggcatcaagc aagtaaaatt tgacagaaat tttaaaatat gaagatgtat agctttccca     2640

agatgatggt aaaacccagg ttagtcatca gtaaccttct ctattattat tattttttag     2700

aaacttggaa tactgtcgtc atggctaaga gaacaaatct gataaattgt gtaacctagt     2760

ctcttctcta catggtgatg catttcagca attataaatt aatataaatg accaaaagta     2820

acttaaaagc atgagatatt tgctatttca ttcattgggc acatatcaaa ttataatttt     2880

gattttaaat ggtcacccat gtatttattt gttgccaagc aagtaaaaaa ataccctaac     2940

aaacctgatg tgggtgggag gggcatgtca gtaagtggtg tgttcaatgt gtttgtttca     3000

tatgggccct ttccaggagt ttgcaaacct tgtcataccc atatgcaaaa ctgtgtttcc     3060

ttgcattaaa ccagtgaagt ttgggttctc ttttgtgcta tcaatcagtt gtaaaatcag     3120

agctgcttat atattctact ggaataactg catcttccac tcagtcacta caaaaaagca     3180

tagtttcagt ttgcatgaat tttttttttt ttcttcaatg gctgtgcaga taaggatcca     3240

tttctgggat agaattgtat tttttaagtc attttttttt cttgaaatgg atatgtacaa     3300

ataaaataaa tggaagacag gataaa                                          3326


<210>  25
<211>  3937
<212>  DNA
<213>  Homo sapiens

<400>  25
agtcttccag cagggttctg aaagcagcct gctcccatcg cgcccctcgg atgtggacac       60

ccagggtggg ctgcagaccg cggccgggcc gcactctctg ggggcgaggg ccaggtcagg      120

tggctgcact gtcgcccagc agcgagtaaa gactcgaaac tgagggagcc agagccctag      180

tcactctgct ggtcgagggt cggaaccgct gggggaaaga ggaaatgtgg acgaaggcag      240

cccttcctgg agacagcttg gaagagaggg atgaagatgc aaaaagcaaa acccaaccta      300

tcaagtgcca cctccccggt gacaggcccc cagccttgct ctgcgctttc gctgaatgaa      360

ctcctgagca cgtttttccc gttgcctagg aagggttggg ccgcaggttt cgccagtgct      420

cgacaaccca cctggagata gcgggtcggg gagggagctg cgaggggggc ggactcctgt      480

tgctcagtct tcagaccgca gcacagcatc atctgcaccg ggacccggga atggggggac      540

acttggagac tgagagagag gaggctcgag gaatgaacct tggtctgttc taagccacaa      600

cccctgtctc aggtcgtttg gcttcctttc cttctctttg tatttgaatt taaaaacatt      660

cctgaatctc aagtgctttt gcttgaagta ggggggagga ggagaaaaga atagaagcaa      720

gccaggcttc ctaagcgagc tctgaaagga gaaatccatt cactgcaaac ctcgttcccc      780

atttctgaaa acggatagac tgatatcgta aactaaaggt catgagggtt tttccccccg      840

gtttggggga tttgttctgt taaaaggaat tttaaagcac cacttgagaa aataattttg      900

cctcagtttc cctaaactat ctttaaaatg ggttgccata attacaggtc ttcttttctc      960

tcacctctat aagccaccgt tttcaggtca tctgaagtca agatttccag ccttttgaat     1020

ggactgatgt gttctaagcc cgaagatcca gtagaatact tggaaagttg tttacaaaaa     1080

gtaaaggaac tgggtggctg tgacaaggtg aaatgggata catttgtaag ccaggaaaag     1140

aagaccttac ctccactaaa tggaggacag tcacggagat cctttctaag aaatgtaatg     1200

cctgaaaact caaactttcc atatcggcgg tatgaccggc tccctccaat ccatcaattc     1260

tccatagaaa gtgacacgga tctctctgag actgcagagt tgattgagga gtatgaggtt     1320

tttgatccta ccagacctcg accaaaaatc attcttgtta taggtggtcc aggaagtgga     1380

aagggtactc agagtttgaa aattgcagaa cgatatggat tccaatacat ttctgtggga     1440

gaattattaa gaaagaagat ccacagtacc agcagcaata ggaaatggag tcttattgcc     1500

aagataatta caactggaga attggcccca caggaaacaa caattacaga gataaaacaa     1560

aaattgatgc aaatacctga tgaagagggc attgttattg atggatttcc aagagatgtt     1620

gcccaggctc tatcttttga ggaccaaatc tgtacccccg atttggtggt attcctggct     1680

tgtgctaatc agagactcaa agaaagatta ctgaagcgtg cagaacagca gggccgacca     1740

gacgacaatg taaaagctac ccaaaggaga ctaatgaact tcaagcagaa tgctgctcca     1800

ttggttaaat acttccagga aaaggggctc atcatgacat ttgatgccga ccgcgatgag     1860

gatgaggtgt tctatgacat cagcatggca gttgacaaca agttatttcc aaacaaagag     1920

gctgcagcag gttcaagtga ccttgatcct tcgatgatat tggacactgg agagatcatt     1980

gatacaggat ctgattatga agatcagggt gatgaccagt taaatgtatt tggagaggac     2040

actatgggag gtttcatgga agatttgaga aagtgtaaaa ttattttcat aattggtggt     2100

cctggctctg gcaaaggcac acagtgtgaa aagctggtgg aaaaatatgg atttacacat     2160

ctctcaactg gcgagctcct gcgtgaggaa ctggcatcag aatctgaaag aagcaaattg     2220

atcagagaca ttatggaacg tggagacctg gtgccctcag gcatcgtttt ggagctcctg     2280

aaggaggcca tggtggccag cctcggggac accaggggct tcctgattga cggctatcct     2340

cgggaggtga agcaagggga agagttcgga cgcaggattg gagacccaca gttggtgatc     2400

tgtatggact gctcggcaga caccatgacc aaccgccttc tccaaaggag ccggagcagc     2460

ctgcctgtgg acgacaccac caagaccatc gccaagcgcc tagaagccta ctaccgagcg     2520

tccatccccg tgatcgccta ctacgagaca aaaacacagc tacacaagat aaatgcagag     2580

ggaacaccag aggacgtttt tcttcaactc tgcacagcta ttgactctat tttctgaagg     2640

caaaaatgca tgtttgttag aatggaaaca gaaaaacatt aaaaagttca ttccttaaca     2700

caatgtttca agttaaacct tttgtgtcac cgcccccacc aaccaccacc tcctaaatcc     2760

tgacagcact gtttgcttcc cagctagacc tgtgtgagag gtgtctggaa atcatgcatg     2820

gtgtatttgg gactatatca acctattctc cacacttcag acaactgtct gcactcacgg     2880

cacacacact ttgtatcatg caggccacac tcagagctag tcagtacatg aacagtggtg     2940

cggtgccagt ctgtgtccgt tgtgatcaca ggccttgcta gaccctgatc atctggttct     3000

cctctcatta agcatcccta acccccagtc acaccttcct cttacatact gttccccaat     3060

ggaggcccct ggcatagggg acagccctgg gcatcttcct ttggtgtctg gctgttttgt     3120

caactctcat ccactggtgg ctcagagcca taaggtgggt tgattacaca atgccttgta     3180

catgatatag aggcatcaag caagtaaaat ttgacagaaa ttttaaaata tgaagatgta     3240

tagctttccc aagatgatgg taaaacccag gttagtcatc agtaaccttc tctattatta     3300

ttatttttta gaaacttgga atactgtcgt catggctaag agaacaaatc tgataaattg     3360

tgtaacctag tctcttctct acatggtgat gcatttcagc aattataaat taatataaat     3420

gaccaaaagt aacttaaaag catgagatat ttgctatttc attcattggg cacatatcaa     3480

attataattt tgattttaaa tggtcaccca tgtatttatt tgttgccaag caagtaaaaa     3540

aataccctaa caaacctgat gtgggtggga ggggcatgtc agtaagtggt gtgttcaatg     3600

tgtttgtttc atatgggccc tttccaggag tttgcaaacc ttgtcatacc catatgcaaa     3660

actgtgtttc cttgcattaa accagtgaag tttgggttct cttttgtgct atcaatcagt     3720

tgtaaaatca gagctgctta tatattctac tggaataact gcatcttcca ctcagtcact     3780

acaaaaaagc atagtttcag tttgcatgaa tttttttttt tttcttcaat ggctgtgcag     3840

ataaggatcc atttctggga tagaattgta ttttttaagt catttttttt tcttgaaatg     3900

gatatgtaca aataaaataa atggaagaca ggataaa                              3937


<210>  26
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Glu Gly Ala Glu Leu Tyr Phe Asn Val Asp His Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Cys Lys Ala Ser Leu Leu Thr Gln Gln Asp 
            20                  25                  30          


Tyr Ile Asn Leu Val Gln Cys Glu Thr Leu Glu Asp Leu Lys Ile His 
        35                  40                  45              


Leu Gln Thr Thr Asp Tyr Gly Asn Phe Leu Ala Asn His Thr Asn Pro 
    50                  55                  60                  


Leu Thr Val Ser Lys Ile Asp Thr Glu Met Arg Lys Arg Leu Cys Gly 
65                  70                  75                  80  


Glu Phe Glu Tyr Phe Arg Asn His Ser Leu Glu Pro Leu Ser Thr Phe 
                85                  90                  95      


Leu Thr Tyr Met Thr Cys Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110         


Met Asn Gly Ala Leu Gln Lys Lys Ser Val Lys Glu Ile Leu Gly Lys 
        115                 120                 125             


Cys His Pro Leu Gly Arg Phe Thr Glu Met Glu Ala Val Asn Ile Ala 
    130                 135                 140                 


Glu Thr Pro Ser Asp Leu Phe Asn Ala Ile Leu Ile Glu Thr Pro Leu 
145                 150                 155                 160 


Ala Pro Phe Phe Gln Asp Cys Met Ser Glu Asn Ala Leu Asp Glu Leu 
                165                 170                 175     


Asn Ile Glu Leu Leu Arg Asn Lys Leu Tyr Lys Ser Tyr Leu Glu Ala 
            180                 185                 190         


Phe Tyr Lys Phe Cys Lys Asn His Gly Asp Val Thr Ala Glu Val Met 
        195                 200                 205             


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Thr 
    210                 215                 220                 


Leu Asn Ser Phe Gly Thr Glu Leu Ser Lys Glu Asp Arg Glu Thr Leu 
225                 230                 235                 240 


Tyr Pro Thr Phe Gly Lys Leu Tyr Pro Glu Gly Leu Arg Leu Leu Ala 
                245                 250                 255     


Gln Ala Glu Asp Phe Asp Gln Met Lys Asn Val Ala Asp His Tyr Gly 
            260                 265                 270         


Val Tyr Lys Pro Leu Phe Glu Ala Val Gly Gly Ser Gly Gly Lys Thr 
        275                 280                 285             


Leu Glu Asp Val Phe Tyr Glu Arg Glu Val Gln Met Asn Val Leu Ala 
    290                 295                 300                 


Phe Asn Arg Gln Phe His Tyr Gly Val Phe Tyr Ala Tyr Val Lys Leu 
305                 310                 315                 320 


Lys Glu Gln Glu Ile Arg Asn Ile Val Trp Ile Ala Glu Cys Ile Ser 
                325                 330                 335     


Gln Arg His Arg Thr Lys Ile Asn Ser Tyr Ile Pro Ile Leu 
            340                 345                 350 


<210>  27
<211>  2370
<212>  DNA
<213>  Homo sapiens

<400>  27
gcaaatcttc aggggccgtc caggactaca gagctgtttc accctacctt ggcttcaatc       60

tcttccccca tgctcgaagg tgcggagctg tacttcaacg tggaccatgg ctacctggag      120

ggcctggttc gaggatgcaa ggccagcctc ctgacccagc aagactatat caacctggtc      180

cagtgtgaga ccctagaaga cctgaaaatt catctccaga ctactgatta tggtaacttt      240

ttggctaatc acacaaatcc tcttactgtt tccaaaattg acactgagat gaggaaaaga      300

ctatgtggag aatttgagta tttccggaat cattccctgg agcccctcag cacatttctc      360

acctatatga cgtgcagtta tatgatagac aatgtgattc tgctgatgaa tggtgcattg      420

cagaaaaaat ctgtgaaaga aattctgggg aagtgccacc ccttgggccg tttcacagaa      480

atggaagctg tcaacattgc agagacacct tcagatctct ttaatgccat tctgatcgaa      540

acgccattag ctccattctt ccaagactgc atgtctgaaa atgctctaga tgaactgaat      600

attgaattgc tacgcaataa actatacaag tcttaccttg aggcattcta taaattctgt      660

aagaatcatg gtgatgtcac agcagaagtt atgtgtccca ttcttgagtt tgaggccgac      720

agacgtgctt ttatcatcac tcttaactcc tttggcactg aattgagcaa agaagaccga      780

gagaccctct atccaacctt cggcaaactc tatcctgagg ggttgcggct gttggctcaa      840

gcagaagact ttgaccagat gaagaacgta gcggatcatt acggagtata caaaccttta      900

tttgaagctg taggtggcag tgggggaaag acattggagg acgtgtttta cgagcgtgag      960

gtacaaatga atgtgctggc attcaacaga cagttccact acggtgtgtt ttatgcatat     1020

gtaaagctga aggaacagga aattagaaat attgtgtgga tagcagaatg tatttcacag     1080

aggcatcgaa ctaaaatcaa cagttacatt ccaattttat aacccaagta aggttctcaa     1140

atgtagaaaa ttataaatgt taaaaggaag ttattgaaga aaataaaaga aattatgtta     1200

tattatctag actacacaaa agtaagccac actatatctt catgagttgc aaatccatgg     1260

aaacacagta aaccagccct gaaacaaagc atttccttgt tttcagtggt attagatctt     1320

gtttccacat gtctgtctca ttcttcactg ggccttacag gttagtttta attaactcta     1380

tggtattttt cttattcttg tttgatcatg ttaaaaattg gacctaataa aagtatttta     1440

ttcttgcttt tccatgcttc tctacaggtc caaatactga atgtctcctt tactttttct     1500

cttttaaatt tttttctaga cagggtctca ctctgtcacc taggctacag tgcagtggtg     1560

tgatcacagc tcactgcagc ctcgacttcc caggctcaag tgatcctccc agctctcagc     1620

ctccaaagta gctggcacta caagtgtaca cccccacaca aggctaagtt ttgtattttt     1680

tgtagagaca gggtttcaac atattatcca ggctggtgtc gaattcctgg gctccaggga     1740

tccacagtcc cccttggcct cccaaagtgt tgggattaca tgcatgagcc actgtgctgg     1800

gcttcattta cattttaact gtctgttcct tgcctagatt cacagaaatc caaagctgta     1860

tgtagtcaac atggttcaca agtgttggaa aatgtgtttt ttgttttgtt ttgttttgtt     1920

tcgttttgtt ttgagacaga gtttccctct gtcgcccagg ctagagtgca atggcgtgat     1980

ctcggctcac tgcaacctcc acctcccaga ttcaagcaac tctctgcctc agcctcccga     2040

gtagctggga ttacaagcac ccaccactac actcagctaa ttttttgtat ttttagtaga     2100

gccggggttt caccatcttg gccaggctga tcttgaactc ctgagctcat gatccacccg     2160

cctcagcctc ccaaagtgct gggattacag gccccttgtt cagccactgc acctggcccc     2220

ttattttgtt tttgttttct aatatacttt gatgtaatca gcttgagaaa gcaacacaat     2280

ttcaaatcct atcttctaga tgcaagcagt gttaaatttg ttaataaatt tgcttttcac     2340

acctttcttt aaataaaagg tatatctctc                                      2370


<210>  28
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Glu Gln Ser Asn Asp Tyr Arg Val Ala Val Phe Gly Ala Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Thr Phe 
            20                  25                  30          


Arg Glu Ser Tyr Ile Pro Thr Val Glu Asp Thr Tyr Arg Gln Val Ile 
        35                  40                  45              


Ser Cys Asp Lys Ser Ile Cys Thr Leu Gln Ile Thr Asp Thr Thr Gly 
    50                  55                  60                  


Ser His Gln Phe Pro Ala Met Gln Arg Leu Ser Ile Ser Lys Gly His 
65                  70                  75                  80  


Ala Phe Ile Leu Val Tyr Ser Ile Thr Ser Arg Gln Ser Leu Glu Glu 
                85                  90                  95      


Leu Lys Pro Ile Tyr Glu Gln Ile Cys Glu Ile Lys Gly Asp Val Glu 
            100                 105                 110         


Ser Ile Pro Ile Met Leu Val Gly Asn Lys Cys Asp Glu Ser Pro Ser 
        115                 120                 125             


Arg Glu Val Gln Ser Ser Glu Ala Glu Ala Leu Ala Arg Thr Trp Lys 
    130                 135                 140                 


Cys Ala Phe Met Glu Thr Ser Ala Lys Leu Asn His Asn Val Lys Glu 
145                 150                 155                 160 


Leu Phe Gln Glu Leu Leu Asn Leu Glu Lys Arg Arg Thr Val Ser Leu 
                165                 170                 175     


Gln Ile Asp Gly Lys Lys Ser Lys Gln Gln Lys Arg Lys Glu Lys Leu 
            180                 185                 190         


Lys Gly Lys Cys Val Ile Met 
        195                 


<210>  29
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  29
atttaagcag gagcagcagc ctctgcagca gttggcacat ctgagaaggc agagattgaa       60

gagagtagga ggagcgtgca gcggcggtga cagtgccagg ccggagcggc tcaggccagc      120

gcaggtgcag gggctgcgag cgggtggagc gcgagggcgc tgggcgcagg gagcacggcc      180

ggtgggcggt gcagggcgca cggcgggcga gcagctgaca gcatcgtcac ggcggcggga      240

gggagtgcgc tgcgcctgcc tccgggagga gccgcatcca cacaccctgc gctgccctgt      300

cctgcgcgag tggagctctg aagaagctct gagcggagtt gtgttcttcc ccaggtgcgt      360

cctggctgag agttggagct ctccagcaac atgcctgagc agagtaacga ttaccgggtg      420

gccgtgtttg gggctggcgg tgttggcaag agctccctgg tgttgaggtt tgtgaaaggc      480

acattccggg agagctacat cccgacggtg gaagacacct accggcaagt gatcagctgt      540

gacaagagca tatgcacatt gcagatcacc gacacgacgg ggagccacca gttcccggcc      600

atgcagcggc tgtccatctc caaagggcac gccttcatcc tggtgtactc cattaccagc      660

cgacagtcct tggaggagct caagcccatc tacgaacaaa tctgcgagat caaaggggac      720

gtggagagca tccccatcat gctggtgggg aacaagtgtg atgagagccc cagccgcgag      780

gtgcagagca gcgaggcgga ggccttggcc cgcacatgga agtgtgcctt catggagacc      840

tcagccaagc tcaaccataa cgtgaaggag cttttccagg agctgctcaa cctggagaag      900

cgcaggaccg tgagtctcca gatcgacggg aaaaagagca agcagcagaa aaggaaagag      960

aagctcaaag gcaagtgcgt gatcatgtga aggcccttcc tgcgggagga gcagctgtgt     1020

gtccccggca cctcactccc ccaaaatgac acccaccgtc gtcagggtag catgtataat     1080

gcccacgtgt taaacattgc atttaatcga gatgcgtcct attgtcctta agagggcgtt     1140

tcacaccacc aacagtaagc cacccactct ggagtcacag aatctgccag gcggttcaag     1200

tgaaaaccaa cacactcagc atccctggga actgagaggt gccagcaatt gctgaaggtg     1260

gcgatgaaca cccgaaggtg ggagggagga ctggtaccca caaagcaaca tgtaccgaga     1320

ggactaaatg tcatctacgt gcatgtgaga gcgtgttaac ctagagttac ctgcaccaac     1380

cccagacaga agccaatcac atctttgggg gaggggaggg gcaggaagag gtgagaagat     1440

cagatggtcc aaagtggacc acacttggtc cattttacac ttttttaaag gggattaaaa     1500

aacacagcct ctcccccaaa gggtgtccgt tcttaattcc cacctggcct gttaggagcc     1560

ttgctaccct gaggggatgt gttcacctta cctagaccta gttaggaagt atcattttaa     1620

gctattagag tatttatctt catgtgcagg gataagtgca ctaacagtgt gctgctctgt     1680

cggaagttct tcagttttta agtgaggata tcgtgacagt attaaaacat cgcaataatg     1740

ttcctgtgtg ttatacatcg agggttttag aaatgtgatt ttcttctttt gacctgtgag     1800

gagtataact tctttcagcc ctcagatttt aaatacaagc aaataaactc actattttta     1860

gacgtttttt tcctccaagg tggttttctt ctcttaaata actcgatctg tacccagctg     1920

ggtagcagcc agcaaaggcc atcagacaac cagaagcaca tccatttttg tagtgtcaca     1980

aacatgtata tgccacactt tgcaccttaa tgaaatactt tgaaacagaa gttattcact     2040

gtgtttttga tgatctatct gtattggaaa tatgttcctg gaaaatgcat ttaaataata     2100

gtaaattctc ttgcatgttc cattatacgt gtcttctaag agctgttcaa tacagtattc     2160

actctagaaa caattatctt tttctcttaa tgattttgtg tgcatcttta atctttcaag     2220

ccaaattaca gctatttcag gtttcctgtg ttagcttggg gataggatgg tggctggaga     2280

caggcaggct tctctgccct gggaagagcc cactcagctt aattgctctg ccatcgtaga     2340

gcctggttgg acttggcttc ctgaaaactc ccactgatag tgcctgttag atctcctgtt     2400

tgtttcagtt ggcagaacat ttactggccc caactgtggc atcatcctct cagcagtctt     2460

cctgtcaccc gcctggcagg cagaaggagc tgcagtccca cgtgggcctg cctggggggg     2520

tgggggctgc atggctgttg ggtggcagtg tcagcacagg gagggcttaa gttggggatg     2580

tttgaccagg ccacctcctg caactgctgt ttctcctgtc cctcctatgc agggcttgca     2640

gcagcagcag tgtggccatc tccatccccc aaagcacact tgctctctca atatgtccta     2700

gttttcttca gccttttctg gttcagttcc cttgtcctga tctcatcctc tctggtctcc     2760

caataactca cccttgggat gtgtttagag cgtgggaggt gcctttgaga actgcttgac     2820

tccatgatct cctagaacaa aaccgccctg actttacagg gggaacactc atgctgagct     2880

gagaaagcag agaagtggcg tgggagccag ctgggggtga agagcatttg ggccagtccc     2940

gtggccccct tcagattcct caagcaggat tgttctgttc taaaaagctg ttgcacagca     3000

ttcgcaatga gatctttagt tggcggattt tctggaacat ttgtttttca acttgtcccg     3060

acattttttt tctgtttcta ttctgagaga gagatgatca agttttaatt tgggtatagg     3120

ttaaatggaa gaagaaacag aacttcatgg ccaaagtaga cctatagatt ttgattgggt     3180

tctttgttaa cagtagaatg cgatctttgc cactgactgt agtattaata aggttttaat     3240

gtgagatatt cctgcaaacc atcccatttc tactgattgt aagtcagaat ttcttttatc     3300

cctttcaaat cagtttctac atgtttaagt gttcagggct tcatcagcat gagaagtttg     3360

taattactga aagtctgatt tcattcagga cacatttttt ccttcatatt ttttctgtga     3420

atttataggc taggaaggct attgaagcct caattatggg tcttcatttt gagatcgttt     3480

tctatgagct gaactgagga tatcaatggt tatctcaaaa tcgtctttta ggagatcccc     3540

aattgactca gagtttgagg agttagtatc acagaattag atttttttaa agcatttgta     3600

cgtttccatt cccaaatatg tagctgtggt tcttgaaaac acatcctaca ttgcatatgg     3660

gcatagcagt ttttgaccca ggcagaataa gttaatattt aattaaatat tgctttgaag     3720

atggcgctct gggcatgagc atggggctcc atgacttccc ttctatcccc atgagcccct     3780

cctccatcca gcgacaagcc atgggcatgc atacaatgca gcaagaccaa cacaagagca     3840

atattgaatt gttcattcta tctaaaatta catgtatata aaatatataa tttatcttcc     3900

tgcatttttg aagtataaag tcataaattg tacatatctg taagctagta tatttgtttc     3960

actgtttgta atatttaaga aatgctcatt ctttgtagaa caaaaatgta ttaaatattt     4020

taaaaattgc tctgtgatac ttaatttttt tccccaaaat ttgtaatgtg ttgcttctac     4080

ataagttctc tggaaatatc tacaactaat aggacacatg taaatccttg aagacacatc     4140

ctggaattca taccccacaa ggacagtgtg tatacaaagt atttgcagag catgactttt     4200

atatgtgtgg gatatcaatg tgtatattta tatttaaagt gtatttattg ttacaagtct     4260

attctctatt atattttatt tactctgcgg ttataaaaat cacccttgca tacaagtttc     4320

tagttgccag tgatgttctg gaaataatgg gagatattac aataaagcta cagttatgac     4380

accctg                                                                4386


<210>  30
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Lys Phe Asn Phe Arg Lys Val Leu Asp Gly Leu Thr Ala Ser 
1               5                   10                  15      


Ser Pro Gly Ser Gly Ser Ser Ser Gly Ser Asn Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Ser Gly Ser Val His Pro Ala Gly Thr Ala Gly Val Leu Arg Glu 
        35                  40                  45              


Glu Ile Gln Glu Thr Leu Thr Ser Glu Tyr Phe Gln Ile Cys Lys Thr 
    50                  55                  60                  


Val Arg His Gly Phe Pro His Gln Pro Thr Ala Leu Ala Phe Asp Pro 
65                  70                  75                  80  


Val Gln Lys Ile Leu Ala Ile Gly Thr Arg Thr Gly Ala Ile Arg Ile 
                85                  90                  95      


Leu Gly Arg Pro Gly Val Asp Cys Tyr Cys Gln His Glu Ser Gly Ala 
            100                 105                 110         


Ala Val Leu Gln Leu Gln Phe Leu Ile Asn Glu Gly Ala Leu Val Ser 
        115                 120                 125             


Ala Ser Ser Asp Asp Thr Leu His Leu Trp Asn Leu Arg Gln Lys Arg 
    130                 135                 140                 


Pro Ala Ile Leu His Ser Leu Lys Phe Asn Arg Glu Arg Ile Thr Tyr 
145                 150                 155                 160 


Cys His Leu Pro Phe Gln Ser Lys Trp Leu Tyr Val Gly Thr Glu Arg 
                165                 170                 175     


Gly Asn Thr His Ile Val Asn Ile Glu Ser Phe Ile Leu Ser Gly Tyr 
            180                 185                 190         


Val Ile Met Trp Asn Lys Ala Ile Glu Leu Ser Thr Lys Thr His Pro 
        195                 200                 205             


Gly Pro Val Val His Leu Ser Asp Ser Pro Arg Asp Glu Gly Lys Leu 
    210                 215                 220                 


Leu Ile Gly Tyr Glu Asn Gly Thr Val Val Phe Trp Asp Leu Lys Ser 
225                 230                 235                 240 


Lys Arg Ala Glu Leu Arg Val Tyr Tyr Asp Glu Ala Ile His Ser Ile 
                245                 250                 255     


Asp Trp His His Glu Gly Lys Gln Phe Met Cys Ser His Ser Asp Gly 
            260                 265                 270         


Ser Leu Thr Leu Trp Asn Leu Lys Ser Pro Ser Arg Pro Phe Gln Thr 
        275                 280                 285             


Thr Ile Pro His Gly Lys Ser Gln Arg Glu Gly Arg Lys Ser Glu Ser 
    290                 295                 300                 


Cys Lys Pro Ile Leu Lys Val Glu Tyr Lys Thr Cys Lys Asn Ser Glu 
305                 310                 315                 320 


Pro Phe Ile Ile Phe Ser Gly Gly Leu Ser Tyr Asp Lys Ala Cys Arg 
                325                 330                 335     


Arg Pro Ser Leu Thr Ile Met His Gly Lys Ala Ile Thr Val Leu Glu 
            340                 345                 350         


Met Asp His Pro Ile Val Glu Phe Leu Thr Leu Cys Glu Thr Pro Tyr 
        355                 360                 365             


Pro Asn Glu Phe Gln Glu Pro Tyr Ala Val Val Val Leu Leu Glu Lys 
    370                 375                 380                 


Asp Leu Ile Val Val Asp Leu Thr Gln Ser Asn Phe Pro Ile Phe Glu 
385                 390                 395                 400 


Asn Pro Tyr Pro Met Asp Ile His Glu Ser Pro Val Thr Cys Thr Ala 
                405                 410                 415     


Tyr Phe Ala Asp Cys Pro Pro Asp Leu Ile Leu Val Leu Tyr Ser Ile 
            420                 425                 430         


Gly Val Lys His Lys Lys Gln Gly Tyr Ser Asn Lys Glu Trp Pro Ile 
        435                 440                 445             


Ser Gly Gly Ala Trp Asn Leu Gly Ala Gln Thr Tyr Pro Glu Ile Ile 
    450                 455                 460                 


Ile Thr Gly His Ala Asp Gly Ser Ile Lys Phe Trp Asp Ala Ser Ala 
465                 470                 475                 480 


Ile Thr Leu Gln Met Leu Tyr Lys Leu Lys Thr Ser Lys Val Phe Glu 
                485                 490                 495     


Lys Gln Lys Val Gly Glu Gly Lys Gln Thr Cys Glu Ile Val Glu Glu 
            500                 505                 510         


Asp Pro Phe Ala Ile Gln Met Ile Tyr Trp Cys Pro Glu Ser Arg Ile 
        515                 520                 525             


Phe Cys Val Ser Gly Val Ser Ala Tyr Val Ile Ile Tyr Lys Phe Ser 
    530                 535                 540                 


Arg His Glu Ile Thr Thr Glu Ile Val Ser Leu Glu Val Arg Leu Gln 
545                 550                 555                 560 


Tyr Asp Val Glu Asp Ile Ile Thr Pro Glu Pro Glu Thr Ser Pro Pro 
                565                 570                 575     


Phe Pro Asp Leu Ser Ala Gln Leu Pro Ser Ser Arg Ser Leu Ser Gly 
            580                 585                 590         


Ser Thr Asn Thr Val Ala Ser Glu Gly Val Thr Lys Asp Ser Ile Pro 
        595                 600                 605             


Cys Leu Asn Val Lys Thr Arg Pro Val Arg Met Pro Pro Gly Tyr Gln 
    610                 615                 620                 


Ala Glu Leu Val Ile Gln Leu Val Trp Val Asp Gly Glu Pro Pro Gln 
625                 630                 635                 640 


Gln Ile Thr Ser Leu Ala Val Ser Ser Ala Tyr Gly Ile Val Ala Phe 
                645                 650                 655     


Gly Asn Cys Asn Gly Leu Ala Val Val Asp Phe Ile Gln Lys Thr Val 
            660                 665                 670         


Leu Leu Ser Met Gly Thr Ile Asp Leu Tyr Arg Ser Ser Asp Leu Tyr 
        675                 680                 685             


Gln Arg Gln Pro Arg Ser Pro Arg Lys Asn Lys Gln Phe Ile Ala Asp 
    690                 695                 700                 


Asn Phe Cys Met Arg Gly Leu Ser Asn Phe Tyr Pro Asp Leu Thr Lys 
705                 710                 715                 720 


Arg Ile Arg Thr Ser Tyr Gln Ser Leu Thr Glu Leu Asn Asp Ser Pro 
                725                 730                 735     


Val Pro Leu Glu Leu Glu Arg Cys Lys Ser Pro Thr Ser Asp His Val 
            740                 745                 750         


Asn Gly His Cys Thr Ser Pro Thr Ser Gln Ser Cys Ser Ser Gly Lys 
        755                 760                 765             


Arg Leu Ser Ser Ala Asp Val Ser Lys Val Asn Arg Trp Gly Pro Gly 
    770                 775                 780                 


Arg Pro Pro Phe Arg Lys Ala Gln Ser Ala Ala Cys Met Glu Ile Ser 
785                 790                 795                 800 


Leu Pro Val Thr Thr Glu Glu Asn Arg Glu Asn Ser Tyr Asn Arg Ser 
                805                 810                 815     


Arg Ser Ser Ser Ile Ser Ser Ile Asp Lys Asp Ser Lys Glu Ala Ile 
            820                 825                 830         


Thr Ala Leu Tyr Phe Met Asp Ser Phe Ala Arg Lys Asn Asp Ser Thr 
        835                 840                 845             


Ile Ser Pro Cys Leu Phe Val Gly Thr Ser Leu Gly Met Val Leu Ile 
    850                 855                 860                 


Ile Ser Leu Asn Leu Pro Leu Ala Asp Glu Gln Arg Phe Thr Glu Pro 
865                 870                 875                 880 


Val Met Val Leu Pro Ser Gly Thr Phe Leu Ser Leu Lys Gly Ala Val 
                885                 890                 895     


Leu Thr Phe Ser Cys Met Asp Arg Met Gly Gly Leu Met Gln Pro Pro 
            900                 905                 910         


Tyr Glu Val Trp Arg Asp Pro Asn Asn Ile Asp Glu Asn Glu Lys Ser 
        915                 920                 925             


Trp Arg Arg Lys Val Val Met Asn Ser Ser Ser Ala Ser Gln Glu Ile 
    930                 935                 940                 


Gly Asp His Gln Tyr Thr Ile Ile Cys Ser Glu Lys Gln Ala Lys Val 
945                 950                 955                 960 


Phe Ser Leu Pro Ser Gln Thr Cys Leu Tyr Val His Asn Ile Thr Glu 
                965                 970                 975     


Thr Ser Phe Ile Leu Gln Ala Asn Val Val Val Met Cys Ser Ser Ala 
            980                 985                 990         


Cys Leu Ala Cys Phe Cys Ala Asn  Gly His Ile Met Ile  Met Ser Leu 
        995                 1000                 1005             


Pro Ser  Leu Arg Pro Met Leu  Asp Val Asn Tyr Leu  Pro Leu Thr 
    1010                 1015                 1020             


Asp Met  Arg Ile Ala Arg Thr  Phe Cys Phe Thr Asn  Glu Gly Gln 
    1025                 1030                 1035             


Ala Leu  Tyr Leu Val Ser Pro  Thr Glu Ile Gln Arg  Leu Thr Tyr 
    1040                 1045                 1050             


Ser Gln  Glu Met Cys Asp Asn  Leu Gln Asp Met Leu  Gly Asp Leu 
    1055                 1060                 1065             


Phe Thr  Pro Ile Glu Thr Pro  Glu Ala Gln Asn Arg  Gly Phe Leu 
    1070                 1075                 1080             


Lys Gly  Leu Phe Gly Gly Ser  Gly Gln Thr Phe Asp  Arg Glu Glu 
    1085                 1090                 1095             


Leu Phe  Gly Glu Ala Ser Ala  Gly Lys Ala Ser Arg  Ser Leu Ala 
    1100                 1105                 1110             


Gln His  Ile Pro Gly Pro Gly  Ser Ile Glu Gly Met  Lys Gly Ala 
    1115                 1120                 1125             


Ala Gly  Gly Val Met Gly Glu  Leu Thr Arg Ala Arg  Ile Ala Leu 
    1130                 1135                 1140             


Asp Glu  Arg Gly Gln Arg Leu  Gly Glu Leu Glu Glu  Lys Thr Ala 
    1145                 1150                 1155             


Gly Met  Met Thr Ser Ala Glu  Ala Phe Ser Lys His  Ala His Glu 
    1160                 1165                 1170             


Leu Met  Leu Lys Tyr Lys Asp  Lys Lys Trp Tyr Gln  Phe 
    1175                 1180                 1185     


<210>  31
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Lys Phe Asn Phe Arg Lys Val Leu Asp Gly Leu Thr Ala Ser 
1               5                   10                  15      


Ser Pro Gly Ser Gly Ser Ser Ser Gly Ser Asn Ser Gly Gly Gly Ala 
            20                  25                  30          


Gly Ser Gly Ser Val His Pro Ala Gly Thr Ala Gly Val Leu Arg Glu 
        35                  40                  45              


Glu Ile Gln Glu Thr Leu Thr Ser Glu Tyr Phe Gln Ile Cys Lys Phe 
    50                  55                  60                  


Gly Met Val Phe Leu Ile Ser Pro Gln His 
65                  70                  


<210>  32
<211>  9382
<212>  DNA
<213>  Homo sapiens

<400>  32
ctgactgctc ggttaggacc tcggagagcg ccaggcgccg cgaccagagg gcccagagaa       60

gcggccggag cccgcctacc tcggccccct cagcttcccg ggctggcagg cggctagagg      120

cgtctgagga agtgtttaaa atgaagaagt ttaatttccg aaaagttttg gatggcttaa      180

ctgcctcctc ccctggcagt ggtagcagca gtggcagtaa cagtggtggt ggggctggaa      240

gtggttccgt acatccggcg gggactgcag gggttctcag agaggaaatt caggaaactt      300

tgacttcgga gtatttccag atttgcaaga cagttcggca tggttttcct catcagccca      360

cagcattagc ctttgatcca gttcagaaaa tcttggctat tgggacgaga acaggtgcta      420

tacgaatact cgggagacct ggtgttgatt gctattgcca acatgaaagt ggtgcagctg      480

tcctacagct ccaatttttg atcaatgagg gtgccttggt cagtgcaagt tcagatgata      540

cacttcattt gtggaacctt agacaaaaaa ggccagccat actccattct cttaaattta      600

accgggaacg aattacttac tgtcatctac ctttccagag taaatggctt tatgttggaa      660

cagaaagagg aaatacacat attgtaaata ttgaatcttt cattctttct ggatatgtta      720

tcatgtggaa caaggcaatt gaactatcca ctaagactca tccaggtcca gttgtacatt      780

taagcgatag cccaagagat gaaggcaaac tgctaatagg ttatgaaaat ggtactgtag      840

tattctggga cttgaaatct aaaagagcag aactgagagt ttattatgat gaggctattc      900

attcaattga ttggcatcat gagggcaaac agttcatgtg cagccattca gatggtagtt      960

tgactttatg gaacctgaaa agcccaagtc gccctttcca gaccacaatt ccacatggaa     1020

aaagtcaaag agaaggaaga aaatctgaat cttgtaaacc aattcttaaa gtagaataca     1080

agacctgcaa aaacagcgaa ccattcataa tattctctgg tgggctgtcc tatgacaaag     1140

cttgtagaag accaagttta accatcatgc atggaaaagc aattacagta cttgaaatgg     1200

atcatcctat tgttgaattt ctaactttat gtgaaacgcc ctatccaaat gaatttcaag     1260

aaccctatgc tgtcgtggta cttctggaga aagatctcat tgtagttgat ctgacacaaa     1320

gcaattttcc aatctttgaa aatccatatc ccatggacat tcatgaatca ccagttacat     1380

gcacagcata ctttgcagat tgtcctccgg atttgattct agtactgtat tctataggag     1440

tcaagcataa aaaacaagga tacagtaata aggagtggcc aatcagtgga ggagcttgga     1500

accttggagc acaaacatat ccagaaatta ttattactgg tcatgcagat ggatcaataa     1560

aattttggga tgcttctgca ataactctgc agatgctgta caagctaaaa acttcaaaag     1620

tgtttgaaaa acagaaggta ggagaaggaa aacaaacatg tgaaattgta gaggaagacc     1680

catttgccat tcagatgatt tactggtgtc cagagagcag aatattctgt gtatcaggag     1740

tctctgcata tgtcataatt tataaattca gcagacatga aattacaaca gaaatagtgt     1800

cattagaggt acgacttcag tatgatgttg aagatattat tacccctgaa ccagaaacaa     1860

gtcctccgtt tccagatctc tcagcccagc ttccttcttc aaggagtctt tctgggagca     1920

ctaacactgt tgctagtgaa ggagtaacaa aggacagtat tccatgcctc aatgtgaaga     1980

cacggccagt gcgaatgcct ccaggatatc aagcagaact tgttattcaa ttggtgtggg     2040

tagatggtga acctccacaa cagattacta gtcttgctgt aagctcagca tatggaatag     2100

ttgcatttgg gaactgcaat gggttggctg tggtggattt tatacagaag acagtactgt     2160

taagcatggg gaccattgac ctatatagat caagtgactt ataccagcga caaccacggt     2220

ctcctcgaaa aaacaaacag ttcattgcag acaacttttg catgcgtggc ctgtctaact     2280

tttatcctga tttaacgaaa cggatccgta cttcctatca gagtttaact gaactgaatg     2340

acagtccagt tcccctagaa cttgagcgct gcaagtctcc tacctcagac catgtaaatg     2400

gacactgcac aagtccaact tctcagagtt gcagttctgg aaaacgtctt tctagtgccg     2460

atgtttcaaa agtaaatcgc tggggtcctg gaagaccacc atttcgaaag gcccagtcag     2520

cagcctgcat ggagatttct ttaccagtta caacagaaga aaaccgagaa aattcctata     2580

atcgttctag aagctctagt atctccagta ttgacaaaga ttctaaagaa gcaattacag     2640

cactatactt catggactcc tttgcacgga aaaatgactc taccatctct ccttgtctgt     2700

tcgttggaac cagtctggga atggtgttaa tcatctcctt aaacctacca ttagcagatg     2760

aacaaaggtt tacagagcca gtcatggtat tgccaagtgg tacattcctc tcattgaaag     2820

gagctgtgct aacattctcc tgtatggacc gaatgggtgg attaatgcaa ccgccatatg     2880

aagtttggag ggatccaaac aacatagatg aaaatgaaaa atcttggaga aggaaagtgg     2940

taatgaactc atcttctgca tcccaagaaa taggagatca tcagtataca ataatctgct     3000

cagaaaaaca agccaaagtc ttctcactgc cttctcagac ttgcctttat gttcataaca     3060

tcacggagac atcttttata ctgcaagcaa atgtggtggt catgtgtagc agtgcctgct     3120

tggcatgctt ttgtgctaac ggacatatca tgataatgag cctacctagt cttcgcccaa     3180

tgttggatgt taattatttg ccactgacag acatgaggat agcacgaaca ttttgtttta     3240

ccaatgaagg acaggcatta tacctcgtct ctcctactga aattcagcgg ttaacataca     3300

gccaagaaat gtgtgataat ctacaggaca tgctaggaga tttgtttact cccatagaga     3360

caccagaagc tcaaaacaga ggctttctca agggactgtt tggtggaagc ggacaaacat     3420

ttgacagaga agagctcttt ggggaagctt cggcaggaaa agcatcccgc agccttgcgc     3480

aacacattcc tggaccaggt agtatagaag ggatgaaagg cgctgctgga ggggtgatgg     3540

gagagctgac ccgtgcacgg attgcacttg atgaaagagg acagaggcta ggagagctgg     3600

aagagaaaac tgcaggcatg atgaccagtg cagaagcatt ttccaaacat gcacatgagt     3660

taatgctgaa atacaaggat aagaaatggt accaattctg acttctaaag aagctgtgac     3720

tgctttgaga aaccatattc agggaaacca aatttattcc cagcatcact actcaactgc     3780

tagaagccag tttcttctac aaaatgttcc atttacagtc aatctgaaat tttcataaaa     3840

gagatgtatc agagacactg tgcaacccaa aggctggagc cctggttaaa atcccaaaat     3900

acggctgaat ttgccttttc ccatgtggaa tggagctatc atcttggcat gtcattcgat     3960

aaggatttat atttagtaac tacggggagt cctcttgatt tgaaaattcc tgtacaaaca     4020

aaagcattaa tgcacttaat gaaaaaaaat ctttgcatga taaattaaca tcttaagggg     4080

aaaagaaaaa aaagcatgtt gtgatagaag aaaaaaagat tcatggtaaa ctatttctat     4140

caattgggcc acactcaaca atttaaaaaa tctgcatttg aagatgtcag tgcatttcaa     4200

atatatttgc catacccaac tgaaacggaa aacaaaacaa aacaagaacc cagagttttc     4260

tcctcatctg taactttcat tgtactagaa ccttattgaa ttcttatggc aagagtctga     4320

ttaatgttct ctctccatgt tttacatcat tcacagttgt gtcaaaatca aatattgcca     4380

gtatagtaaa ttattcccaa cacaatcagt ttcatttcta tcaccttcag aatgggttgc     4440

tgtttttagc acaaaccatg cagggttggg tcacctcaaa gcattttctt cagcctggct     4500

tgtactctat aggggagttg gtagtaggtg tggggaatct ataggaacaa tagagttagc     4560

tatgagaact gacttcacaa aaagggaaat ttcacacacc ccaatttcag cttctaaagt     4620

gatatatttt aaaagcttca tttgtatcct tgtctgccag ttacacagta tattactgtt     4680

caaacccagt agggtctgca atcgaaaggt gctcttgcag cctgacattc acaaaccaaa     4740

ctggtcattc tctttagtgt gattcagtaa aatctcagtt aatgttttgg gaaagggatt     4800

ctgatttatg acatttctga tttacaaggg ctttccttag aaaatacctt tcggtttgat     4860

acttaccact ggaaattggt tcgatactta ccactggaaa tctttataaa atatagtgat     4920

ctgtttgcta tcttggtctc agtcatcatt atagacaata gaaatacata aagagtttaa     4980

tgatacaaaa tcaatgcttt tgtccctagg tcaaataata taagccacta gattatgtca     5040

atagatgcca aacacttgtc ccttattaaa gactctttta aagctggaat aaagaatatc     5100

cttaacatga tacaaggtat ctataactca ccagaaaagc accagagtca aaaccaaata     5160

gagacaccta ctaccattta acatgattct ggaagtcaaa agttatagga atgtatatat     5220

acacattcca ggacccatcc tgtaatatgt tgtttcgtca agaaaagttt taattatggt     5280

tttggcttat tgaatttttg tttatcaagg tctcattgga tttacatttg tgtttcttaa     5340

gacttcacaa ttttcctgga tttcaggtta ttttattagc caaaaaatcg tatttttatt     5400

tcctttttag tctaattttt tgctagaagt tgtactttct agcaaatgtt tctagtggta     5460

caatgttctc agtaattttg aggagaacaa agatgagtga aagagttaga taatgtacac     5520

taggatagca tttctcagag tccttgaatc ctcttgttaa gaaagcctct ctgaatctcc     5580

cagactcctg tgaacagcct tacggtaaca gaatctggct tggaaacaca gacattacat     5640

gactgtataa tttatagaat tataaaatta tatggtaaaa atattaaaga aacttaagag     5700

taggatctag aaaatactag tggccaaatt gcaatgtatt ctttgtacca tctgtttcaa     5760

agacttagtt ttctgatttt cagaacaaat actttatcgt ttctgtattt taaaaaaaac     5820

taaaagagta aaatattagt ttattttaga aataatgaaa ttcagtccaa agtagcagta     5880

catttgatga gtatttctga agccttcaat aagatttaac ttgttttaac ttgatctaca     5940

tcgagatttc tcaaaagcag cactattagc tgaaagtctt tgttgtgggg aactgtcctg     6000

tgtattgtag gatgttagca acatccctgg cctctgtcta ctagatgcca gtaagaacct     6060

cctagtaatg acaatcaaaa tgtctccagt cattgccaaa atttctccca gttcacagcc     6120

actattctac atcatacaaa gaggtagatt gtgtgaatat gtaatatatg ttgttgtata     6180

aaactgtaca ataagtatac aatgtcttag caagataaat tattataccc aaaattacat     6240

gtgtggttca tatgcaataa gatacaattt tgaagaaagc ttataggaat cagtgaaaaa     6300

taacaactac agaatatttt aaggcacaca gagaaaatat caaaaaggac attatagcat     6360

ttcactgtag aagtgcttaa aaccttggcc tcagtgaata gatcaaaagt ttataattag     6420

cacaccaatt ggaagtaaac aggtgcttct caaatgcttg aaaagaaaag gctctttgaa     6480

gtagttaaaa cgtgtctttc aaaattgctt ttataagccc ttccttaacg taagggtaac     6540

ttcatctcac aaactcctgg ttagtggaat ccaaattaat gaggttttac tgtatcaaaa     6600

ttatttttat aattcaaaga gatgatagca ataagaagaa tctaatgtgg atgtgatttt     6660

tctctttgaa caattctgtt ctgttgcact gaccttagca cgcacgcaca cacacacaca     6720

ccatcgccac cactaccatc atcatcttat cctcatcttt ggaaaataag tactgttgat     6780

ccatgtaatc ctttgcatag tctcatcttt actatctttc ttctatttcg gaacataaga     6840

aaaatactcc taataacttg gacaatgata cagaaagtga ctctgagcct tagttaccat     6900

caaaattaca ttctatctgc taaagcgaca tcagaagata aggcttgcaa accacagtcc     6960

caacaagttg accttgtctc cctatgattt ccttggaaga taaggccttt ttagtgttac     7020

agtagaaaat gggccttttc atttattcat ctgtgagaag ctagaggtat ttgtttccct     7080

gataataacg tgagcaatag tccctacctt gaaatcatcc attagtcttg gagtttggag     7140

ggaggaatga ttgattcctc atttgtttta atcacctaca aaagcagtac tactgacttt     7200

gcttcttaca cttcactgag ccccagactt tagggcccca atcattgtca agatcattgt     7260

ctaactggaa ctctgaaagg acagtgacag aactgaatga gatgttttcc agtgattcag     7320

tcacaaagac aattttctca gatcttttga aagtgattct caaataaata aatcaaaatc     7380

caactccttt ccctcaaagt ttctagggat ctgaaggaaa aggtttactg ttggagtccc     7440

tttttatgtg acccatgtac cagttttaaa ggcatcatct atactttatc tacatgaagg     7500

gatcaccatg actttgagag aaaaaagaat cagattaggc ctaacattgg ttgaagaaga     7560

ttaaaataga ttcttatatt caagcagaag ggaaaaatga agccaatcta gaaaagtaag     7620

ctaaaaatcc tctccttggc ttaggatcat tgggtcaaac tgggagtata tctgtgtgat     7680

tacaacctgc tgctatgaga aaaaagaatt gtaacttgac catgttggct cacacagggc     7740

aatgcaaaag aagtcaaaac attcatatca ggtcttggta tctgtgtcag gagaaacgtg     7800

gtggctttca cagcttcttc acctctgtcc tctgtcatgc aactccattt ttggctaggt     7860

actatttcac atgcacactg tcctgggtgc cagaaatact tgtggtgtac ttggtttgag     7920

cagtacctct agtatgcacc attccaggga acatggttgt caacataaca agtttagtgt     7980

gtgtatttgc agacaacata gccctgaaag catgaaatgt agaataggta aggtctgtct     8040

tagaaaagga ggaggaagta ccaatttggt gcaagaagat cgtggtgagg aaggacatgg     8100

gagccacagt gaagtgaaag aggctttaag gaatcagatg cacagatgga tgctttgatt     8160

tacacattta tctagaggag tgattctcaa ccttgactgt acataagaat cacctcagga     8220

aatttttaaa ttcccaatta tattaaaatc atttggagtg ggaaccagac accaatattt     8280

gcgaaagcct ccaaggcggt tctaatgtcc agccaaagtt gattatcact gctttatggc     8340

caactaagga aaccttgttt gtctgccttg gctggtgctc cagccccagt tctgagtggt     8400

cagggaaggc aagatgtaag atatagtaat ggtatttatt ctgtatgtct cacagaacaa     8460

aagcatttga gaatttctga ccaggcagtg ctccatcaac tcttaataat catctttgtg     8520

atattctcct atgtgacttg tccatcaatt attccaattc aaaggtctag gttttttttc     8580

aattgtctta cacatgtgac atcacaagat accagaagta gcacagtaaa ttcaagagca     8640

tataaagcta agtggaaaac taattcttca tatttagaca gtggaaattc tcaaaacaat     8700

catttgctaa attaggtcca aatttattat tcattcttct tctggaggag acatgggtac     8760

caggtacctg ttctgctgta ggtatatttc actggacttg gtcttagcaa aaaggaagaa     8820

caaatcttcc tttttgattg ttatctcaat caaaagctcc cagggccact tggatttatt     8880

ttcttagtct ttggacatgt gtttaaagga aaagaatacc tgtaacttcc tatatgacat     8940

ccagtgccct gaaagggtgc ttacaccttc aaaaaaggag agtccagcct atcaaaggca     9000

gtaacacata atgagaagaa actcagagtt attgcctttc atactgcttt ccctctgctg     9060

ttggcccacc cttcttgact gcaaagccag aaaataaact agatggtggt tttggacaat     9120

tgtacacagg aacagaatct ctaataacct ataattttta gtacttaatt atgtgatgtt     9180

ttattctagg aaataagaaa cagatgacat cattgatgta tctttctttc atcttcagaa     9240

tttttgcatc ttttcagaaa atgacaaatt actatttttc tgttgcactc agcaattgtg     9300

actatactta acaaaattct tgtagtctgt agagatatca ataaaattgt atatgtttgt     9360

acataaaaaa aaaaaaaaaa aa                                              9382


<210>  33
<211>  9310
<212>  DNA
<213>  Homo sapiens

<400>  33
ctgactgctc ggttaggacc tcggagagcg ccaggcgccg cgaccagagg gcccagagaa       60

gcggccggag cccgcctacc tcggccccct cagcttcccg ggctggcagg cggctagagg      120

cgtctgagga agtgtttaaa atgaagaagt ttaatttccg aaaagttttg gatggcttaa      180

ctgcctcctc ccctggcagt ggtagcagca gtggcagtaa cagtggtggt ggggctggaa      240

gtggttccgt acatccggcg gggactgcag gggttctcag agaggaaatt caggaaactt      300

tgacttcgga gtatttccag atttgcaaga cagttcggca tggttttcct catcagccca      360

cagcattagc ctttgatcca gttcagaaaa tcttggctat tgggacgaga acaggtgcta      420

tacgaatact cgggagacct ggtgttgatt gctattgcca acatgaaagt ggtgcagctg      480

tcctacagct ccaatttttg atcaatgagg gtgccttggt cagtgcaagt tcagatgata      540

cacttcattt gtggaacctt agacaaaaaa ggccagccat actccattct cttaaattta      600

accgggaacg aattacttac tgtcatctac ctttccagag taaatggctt tatgttggaa      660

cagaaagagg aaatacacat attgtaaata ttgaatcttt cattctttct ggatatgtta      720

tcatgtggaa caaggcaatt gaactatcca ctaagactca tccaggtcca gttgtacatt      780

taagcgatag cccaagagat gaaggcaaac tgctaatagg ttatgaaaat ggtactgtag      840

tattctggga cttgaaatct aaaagagcag aactgagagt ttattatgat gaggctattc      900

attcaattga ttggcatcat gagggcaaac agttcatgtg cagccattca gatggtagtt      960

tgactttatg gaacctgaaa agcccaagtc gccctttcca gaccacaatt ccacatggaa     1020

aaagtcaaag agaaggaaga aaatctgaat cttgtaaacc aattcttaaa gtagaataca     1080

agacctgcaa aaacagcgaa ccattcataa tattctctgg tgggctgtcc tatgacaaag     1140

cttgtagaag accaagttta accatcatgc atggaaaagc aattacagta cttgaaatgg     1200

atcatcctat tgttgaattt ctaactttat gtgaaacgcc ctatccaaat gaatttcaag     1260

aaccctatgc tgtcgtggta cttctggaga aagatctcat tgtagttgat ctgacacaaa     1320

gcaattttcc aatctttgaa aatccatatc ccatggacat tcatgaatca ccagttacat     1380

gcacagcata ctttgcagat tgtcctccgg atttgattct agtactgtat tctataggag     1440

tcaagcataa aaaacaagga tacagtaata aggagtggcc aatcagtgga ggagcttgga     1500

accttggagc acaaacatat ccagaaatta ttattactgg tcatgcagat ggatcaataa     1560

aattttggga tgcttctgca ataactctgc agatgctgta caagctaaaa acttcaaaag     1620

tgtttgaaaa acagaaggta ggagaaggaa aacaaacatg tgaaattgta gaggaagacc     1680

catttgccat tcagatgatt tactggtgtc cagagagcag aatattctgt gtatcaggag     1740

tctctgcata tgtcataatt tataaattca gcagacatga aattacaaca gaaatagtgt     1800

cattagaggt acgacttcag tatgatgttg aagatattat tacccctgaa ccagaaacaa     1860

gtcctccgtt tccagatctc tcagcccagc ttccttcttc aaggagtctt tctgggagca     1920

ctaacactgt tgctagtgaa ggagtaacaa aggacagtat tccatgcctc aatgtgaaga     1980

cacggccagt gcgaatgcct ccaggatatc aagcagaact tgttattcaa ttggtgtggg     2040

tagatggtga acctccacaa cagattacta gtcttgctgt aagctcagca tatggaatag     2100

ttgcatttgg gaactgcaat gggttggctg tggtggattt tatacagaag acagtactgt     2160

taagcatggg gaccattgac ctatatagat caagtgactt ataccagcga caaccacggt     2220

ctcctcgaaa aaacaaacag ttcattgcag gtttaactga actgaatgac agtccagttc     2280

ccctagaact tgagcgctgc aagtctccta cctcagacca tgtaaatgga cactgcacaa     2340

gtccaacttc tcagagttgc agttctggaa aacgtctttc tagtgccgat gtttcaaaag     2400

taaatcgctg gggtcctgga agaccaccat ttcgaaaggc ccagtcagca gcctgcatgg     2460

agatttcttt accagttaca acagaagaaa accgagaaaa ttcctataat cgttctagaa     2520

gctctagtat ctccagtatt gacaaagatt ctaaagaagc aattacagca ctatacttca     2580

tggactcctt tgcacggaaa aatgactcta ccatctctcc ttgtctgttc gttggaacca     2640

gtctgggaat ggtgttaatc atctccttaa acctaccatt agcagatgaa caaaggttta     2700

cagagccagt catggtattg ccaagtggta cattcctctc attgaaagga gctgtgctaa     2760

cattctcctg tatggaccga atgggtggat taatgcaacc gccatatgaa gtttggaggg     2820

atccaaacaa catagatgaa aatgaaaaat cttggagaag gaaagtggta atgaactcat     2880

cttctgcatc ccaagaaata ggagatcatc agtatacaat aatctgctca gaaaaacaag     2940

ccaaagtctt ctcactgcct tctcagactt gcctttatgt tcataacatc acggagacat     3000

cttttatact gcaagcaaat gtggtggtca tgtgtagcag tgcctgcttg gcatgctttt     3060

gtgctaacgg acatatcatg ataatgagcc tacctagtct tcgcccaatg ttggatgtta     3120

attatttgcc actgacagac atgaggatag cacgaacatt ttgttttacc aatgaaggac     3180

aggcattata cctcgtctct cctactgaaa ttcagcggtt aacatacagc caagaaatgt     3240

gtgataatct acaggacatg ctaggagatt tgtttactcc catagagaca ccagaagctc     3300

aaaacagagg ctttctcaag ggactgtttg gtggaagcgg acaaacattt gacagagaag     3360

agctctttgg ggaagcttcg gcaggaaaag catcccgcag ccttgcgcaa cacattcctg     3420

gaccaggtag tatagaaggg atgaaaggcg ctgctggagg ggtgatggga gagctgaccc     3480

gtgcacggat tgcacttgat gaaagaggac agaggctagg agagctggaa gagaaaactg     3540

caggcatgat gaccagtgca gaagcatttt ccaaacatgc acatgagtta atgctgaaat     3600

acaaggataa gaaatggtac caattctgac ttctaaagaa gctgtgactg ctttgagaaa     3660

ccatattcag ggaaaccaaa tttattccca gcatcactac tcaactgcta gaagccagtt     3720

tcttctacaa aatgttccat ttacagtcaa tctgaaattt tcataaaaga gatgtatcag     3780

agacactgtg caacccaaag gctggagccc tggttaaaat cccaaaatac ggctgaattt     3840

gccttttccc atgtggaatg gagctatcat cttggcatgt cattcgataa ggatttatat     3900

ttagtaacta cggggagtcc tcttgatttg aaaattcctg tacaaacaaa agcattaatg     3960

cacttaatga aaaaaaatct ttgcatgata aattaacatc ttaaggggaa aagaaaaaaa     4020

agcatgttgt gatagaagaa aaaaagattc atggtaaact atttctatca attgggccac     4080

actcaacaat ttaaaaaatc tgcatttgaa gatgtcagtg catttcaaat atatttgcca     4140

tacccaactg aaacggaaaa caaaacaaaa caagaaccca gagttttctc ctcatctgta     4200

actttcattg tactagaacc ttattgaatt cttatggcaa gagtctgatt aatgttctct     4260

ctccatgttt tacatcattc acagttgtgt caaaatcaaa tattgccagt atagtaaatt     4320

attcccaaca caatcagttt catttctatc accttcagaa tgggttgctg tttttagcac     4380

aaaccatgca gggttgggtc acctcaaagc attttcttca gcctggcttg tactctatag     4440

gggagttggt agtaggtgtg gggaatctat aggaacaata gagttagcta tgagaactga     4500

cttcacaaaa agggaaattt cacacacccc aatttcagct tctaaagtga tatattttaa     4560

aagcttcatt tgtatccttg tctgccagtt acacagtata ttactgttca aacccagtag     4620

ggtctgcaat cgaaaggtgc tcttgcagcc tgacattcac aaaccaaact ggtcattctc     4680

tttagtgtga ttcagtaaaa tctcagttaa tgttttggga aagggattct gatttatgac     4740

atttctgatt tacaagggct ttccttagaa aatacctttc ggtttgatac ttaccactgg     4800

aaattggttc gatacttacc actggaaatc tttataaaat atagtgatct gtttgctatc     4860

ttggtctcag tcatcattat agacaataga aatacataaa gagtttaatg atacaaaatc     4920

aatgcttttg tccctaggtc aaataatata agccactaga ttatgtcaat agatgccaaa     4980

cacttgtccc ttattaaaga ctcttttaaa gctggaataa agaatatcct taacatgata     5040

caaggtatct ataactcacc agaaaagcac cagagtcaaa accaaataga gacacctact     5100

accatttaac atgattctgg aagtcaaaag ttataggaat gtatatatac acattccagg     5160

acccatcctg taatatgttg tttcgtcaag aaaagtttta attatggttt tggcttattg     5220

aatttttgtt tatcaaggtc tcattggatt tacatttgtg tttcttaaga cttcacaatt     5280

ttcctggatt tcaggttatt ttattagcca aaaaatcgta tttttatttc ctttttagtc     5340

taattttttg ctagaagttg tactttctag caaatgtttc tagtggtaca atgttctcag     5400

taattttgag gagaacaaag atgagtgaaa gagttagata atgtacacta ggatagcatt     5460

tctcagagtc cttgaatcct cttgttaaga aagcctctct gaatctccca gactcctgtg     5520

aacagcctta cggtaacaga atctggcttg gaaacacaga cattacatga ctgtataatt     5580

tatagaatta taaaattata tggtaaaaat attaaagaaa cttaagagta ggatctagaa     5640

aatactagtg gccaaattgc aatgtattct ttgtaccatc tgtttcaaag acttagtttt     5700

ctgattttca gaacaaatac tttatcgttt ctgtatttta aaaaaaacta aaagagtaaa     5760

atattagttt attttagaaa taatgaaatt cagtccaaag tagcagtaca tttgatgagt     5820

atttctgaag ccttcaataa gatttaactt gttttaactt gatctacatc gagatttctc     5880

aaaagcagca ctattagctg aaagtctttg ttgtggggaa ctgtcctgtg tattgtagga     5940

tgttagcaac atccctggcc tctgtctact agatgccagt aagaacctcc tagtaatgac     6000

aatcaaaatg tctccagtca ttgccaaaat ttctcccagt tcacagccac tattctacat     6060

catacaaaga ggtagattgt gtgaatatgt aatatatgtt gttgtataaa actgtacaat     6120

aagtatacaa tgtcttagca agataaatta ttatacccaa aattacatgt gtggttcata     6180

tgcaataaga tacaattttg aagaaagctt ataggaatca gtgaaaaata acaactacag     6240

aatattttaa ggcacacaga gaaaatatca aaaaggacat tatagcattt cactgtagaa     6300

gtgcttaaaa ccttggcctc agtgaataga tcaaaagttt ataattagca caccaattgg     6360

aagtaaacag gtgcttctca aatgcttgaa aagaaaaggc tctttgaagt agttaaaacg     6420

tgtctttcaa aattgctttt ataagccctt ccttaacgta agggtaactt catctcacaa     6480

actcctggtt agtggaatcc aaattaatga ggttttactg tatcaaaatt atttttataa     6540

ttcaaagaga tgatagcaat aagaagaatc taatgtggat gtgatttttc tctttgaaca     6600

attctgttct gttgcactga ccttagcacg cacgcacaca cacacacacc atcgccacca     6660

ctaccatcat catcttatcc tcatctttgg aaaataagta ctgttgatcc atgtaatcct     6720

ttgcatagtc tcatctttac tatctttctt ctatttcgga acataagaaa aatactccta     6780

ataacttgga caatgataca gaaagtgact ctgagcctta gttaccatca aaattacatt     6840

ctatctgcta aagcgacatc agaagataag gcttgcaaac cacagtccca acaagttgac     6900

cttgtctccc tatgatttcc ttggaagata aggccttttt agtgttacag tagaaaatgg     6960

gccttttcat ttattcatct gtgagaagct agaggtattt gtttccctga taataacgtg     7020

agcaatagtc cctaccttga aatcatccat tagtcttgga gtttggaggg aggaatgatt     7080

gattcctcat ttgttttaat cacctacaaa agcagtacta ctgactttgc ttcttacact     7140

tcactgagcc ccagacttta gggccccaat cattgtcaag atcattgtct aactggaact     7200

ctgaaaggac agtgacagaa ctgaatgaga tgttttccag tgattcagtc acaaagacaa     7260

ttttctcaga tcttttgaaa gtgattctca aataaataaa tcaaaatcca actcctttcc     7320

ctcaaagttt ctagggatct gaaggaaaag gtttactgtt ggagtccctt tttatgtgac     7380

ccatgtacca gttttaaagg catcatctat actttatcta catgaaggga tcaccatgac     7440

tttgagagaa aaaagaatca gattaggcct aacattggtt gaagaagatt aaaatagatt     7500

cttatattca agcagaaggg aaaaatgaag ccaatctaga aaagtaagct aaaaatcctc     7560

tccttggctt aggatcattg ggtcaaactg ggagtatatc tgtgtgatta caacctgctg     7620

ctatgagaaa aaagaattgt aacttgacca tgttggctca cacagggcaa tgcaaaagaa     7680

gtcaaaacat tcatatcagg tcttggtatc tgtgtcagga gaaacgtggt ggctttcaca     7740

gcttcttcac ctctgtcctc tgtcatgcaa ctccattttt ggctaggtac tatttcacat     7800

gcacactgtc ctgggtgcca gaaatacttg tggtgtactt ggtttgagca gtacctctag     7860

tatgcaccat tccagggaac atggttgtca acataacaag tttagtgtgt gtatttgcag     7920

acaacatagc cctgaaagca tgaaatgtag aataggtaag gtctgtctta gaaaaggagg     7980

aggaagtacc aatttggtgc aagaagatcg tggtgaggaa ggacatggga gccacagtga     8040

agtgaaagag gctttaagga atcagatgca cagatggatg ctttgattta cacatttatc     8100

tagaggagtg attctcaacc ttgactgtac ataagaatca cctcaggaaa tttttaaatt     8160

cccaattata ttaaaatcat ttggagtggg aaccagacac caatatttgc gaaagcctcc     8220

aaggcggttc taatgtccag ccaaagttga ttatcactgc tttatggcca actaaggaaa     8280

ccttgtttgt ctgccttggc tggtgctcca gccccagttc tgagtggtca gggaaggcaa     8340

gatgtaagat atagtaatgg tatttattct gtatgtctca cagaacaaaa gcatttgaga     8400

atttctgacc aggcagtgct ccatcaactc ttaataatca tctttgtgat attctcctat     8460

gtgacttgtc catcaattat tccaattcaa aggtctaggt tttttttcaa ttgtcttaca     8520

catgtgacat cacaagatac cagaagtagc acagtaaatt caagagcata taaagctaag     8580

tggaaaacta attcttcata tttagacagt ggaaattctc aaaacaatca tttgctaaat     8640

taggtccaaa tttattattc attcttcttc tggaggagac atgggtacca ggtacctgtt     8700

ctgctgtagg tatatttcac tggacttggt cttagcaaaa aggaagaaca aatcttcctt     8760

tttgattgtt atctcaatca aaagctccca gggccacttg gatttatttt cttagtcttt     8820

ggacatgtgt ttaaaggaaa agaatacctg taacttccta tatgacatcc agtgccctga     8880

aagggtgctt acaccttcaa aaaaggagag tccagcctat caaaggcagt aacacataat     8940

gagaagaaac tcagagttat tgcctttcat actgctttcc ctctgctgtt ggcccaccct     9000

tcttgactgc aaagccagaa aataaactag atggtggttt tggacaattg tacacaggaa     9060

cagaatctct aataacctat aatttttagt acttaattat gtgatgtttt attctaggaa     9120

ataagaaaca gatgacatca ttgatgtatc tttctttcat cttcagaatt tttgcatctt     9180

ttcagaaaat gacaaattac tatttttctg ttgcactcag caattgtgac tatacttaac     9240

aaaattcttg tagtctgtag agatatcaat aaaattgtat atgtttgtac ataaaaaaaa     9300

aaaaaaaaaa                                                            9310


<210>  34
<211>  9302
<212>  DNA
<213>  Homo sapiens

<400>  34
gtgcagcggg gagagcggac ggcgggcggg cgaacaggcg ggagagcgcg gcggcggctg       60

cgggcagagt gtttaaaatg aagaagttta atttccgaaa agttttggat ggcttaactg      120

cctcctcccc tggcagtggt agcagcagtg gcagtaacag tggtggtggg gctggaagtg      180

gttccgtaca tccggcgggg actgcagggg ttctcagaga ggaaattcag gaaactttga      240

cttcggagta tttccagatt tgcaagacag ttcggcatgg ttttcctcat cagcccacag      300

cattagcctt tgatccagtt cagaaaatct tggctattgg gacgagaaca ggtgctatac      360

gaatactcgg gagacctggt gttgattgct attgccaaca tgaaagtggt gcagctgtcc      420

tacagctcca atttttgatc aatgagggtg ccttggtcag tgcaagttca gatgatacac      480

ttcatttgtg gaaccttaga caaaaaaggc cagccatact ccattctctt aaatttaacc      540

gggaacgaat tacttactgt catctacctt tccagagtaa atggctttat gttggaacag      600

aaagaggaaa tacacatatt gtaaatattg aatctttcat tctttctgga tatgttatca      660

tgtggaacaa ggcaattgaa ctatccacta agactcatcc aggtccagtt gtacatttaa      720

gcgatagccc aagagatgaa ggcaaactgc taataggtta tgaaaatggt actgtagtat      780

tctgggactt gaaatctaaa agagcagaac tgagagttta ttatgatgag gctattcatt      840

caattgattg gcatcatgag ggcaaacagt tcatgtgcag ccattcagat ggtagtttga      900

ctttatggaa cctgaaaagc ccaagtcgcc ctttccagac cacaattcca catggaaaaa      960

gtcaaagaga aggaagaaaa tctgaatctt gtaaaccaat tcttaaagta gaatacaaga     1020

cctgcaaaaa cagcgaacca ttcataatat tctctggtgg gctgtcctat gacaaagctt     1080

gtagaagacc aagtttaacc atcatgcatg gaaaagcaat tacagtactt gaaatggatc     1140

atcctattgt tgaatttcta actttatgtg aaacgcccta tccaaatgaa tttcaagaac     1200

cctatgctgt cgtggtactt ctggagaaag atctcattgt agttgatctg acacaaagca     1260

attttccaat ctttgaaaat ccatatccca tggacattca tgaatcacca gttacatgca     1320

cagcatactt tgcagattgt cctccggatt tgattctagt actgtattct ataggagtca     1380

agcataaaaa acaaggatac agtaataagg agtggccaat cagtggagga gcttggaacc     1440

ttggagcaca aacatatcca gaaattatta ttactggtca tgcagatgga tcaataaaat     1500

tttgggatgc ttctgcaata actctgcaga tgctgtacaa gctaaaaact tcaaaagtgt     1560

ttgaaaaaca gaaggtagga gaaggaaaac aaacatgtga aattgtagag gaagacccat     1620

ttgccattca gatgatttac tggtgtccag agagcagaat attctgtgta tcaggagtct     1680

ctgcatatgt cataatttat aaattcagca gacatgaaat tacaacagaa atagtgtcat     1740

tagaggtacg acttcagtat gatgttgaag atattattac ccctgaacca gaaacaagtc     1800

ctccgtttcc agatctctca gcccagcttc cttcttcaag gagtctttct gggagcacta     1860

acactgttgc tagtgaagga gtaacaaagg acagtattcc atgcctcaat gtgaagacac     1920

ggccagtgcg aatgcctcca ggatatcaag cagaacttgt tattcaattg gtgtgggtag     1980

atggtgaacc tccacaacag attactagtc ttgctgtaag ctcagcatat ggaatagttg     2040

catttgggaa ctgcaatggg ttggctgtgg tggattttat acagaagaca gtactgttaa     2100

gcatggggac cattgaccta tatagatcaa gtgacttata ccagcgacaa ccacggtctc     2160

ctcgaaaaaa caaacagttc attgcagaca acttttgcat gcgtggcctg tctaactttt     2220

atcctgattt aacgaaacgg atccgtactt cctatcagag tttaactgaa ctgaatgaca     2280

gtccagttcc cctagaactt gagcgctgca agtctcctac ctcagaccat gtaaatggac     2340

actgcacaag tccaacttct cagagttgca gttctggaaa acgtctttct agtgccgatg     2400

tttcaaaagt aaatcgctgg ggtcctggaa gaccaccatt tcgaaaggcc cagtcagcag     2460

cctgcatgga gatttcttta ccagttacaa cagaagaaaa ccgagaaaat tcctataatc     2520

gttctagaag ctctagtatc tccagtattg acaaagattc taaagaagca attacagcac     2580

tatacttcat ggactccttt gcacggaaaa atgactctac catctctcct tgtctgttcg     2640

ttggaaccag tctgggaatg gtgttaatca tctccttaaa cctaccatta gcagatgaac     2700

aaaggtttac agagccagtc atggtattgc caagtggtac attcctctca ttgaaaggag     2760

ctgtgctaac attctcctgt atggaccgaa tgggtggatt aatgcaaccg ccatatgaag     2820

tttggaggga tccaaacaac atagatgaaa atgaaaaatc ttggagaagg aaagtggtaa     2880

tgaactcatc ttctgcatcc caagaaatag gagatcatca gtatacaata atctgctcag     2940

aaaaacaagc caaagtcttc tcactgcctt ctcagacttg cctttatgtt cataacatca     3000

cggagacatc ttttatactg caagcaaatg tggtggtcat gtgtagcagt gcctgcttgg     3060

catgcttttg tgctaacgga catatcatga taatgagcct acctagtctt cgcccaatgt     3120

tggatgttaa ttatttgcca ctgacagaca tgaggatagc acgaacattt tgttttacca     3180

atgaaggaca ggcattatac ctcgtctctc ctactgaaat tcagcggtta acatacagcc     3240

aagaaatgtg tgataatcta caggacatgc taggagattt gtttactccc atagagacac     3300

cagaagctca aaacagaggc tttctcaagg gactgtttgg tggaagcgga caaacatttg     3360

acagagaaga gctctttggg gaagcttcgg caggaaaagc atcccgcagc cttgcgcaac     3420

acattcctgg accaggtagt atagaaggga tgaaaggcgc tgctggaggg gtgatgggag     3480

agctgacccg tgcacggatt gcacttgatg aaagaggaca gaggctagga gagctggaag     3540

agaaaactgc aggcatgatg accagtgcag aagcattttc caaacatgca catgagttaa     3600

tgctgaaata caaggataag aaatggtacc aattctgact tctaaagaag ctgtgactgc     3660

tttgagaaac catattcagg gaaaccaaat ttattcccag catcactact caactgctag     3720

aagccagttt cttctacaaa atgttccatt tacagtcaat ctgaaatttt cataaaagag     3780

atgtatcaga gacactgtgc aacccaaagg ctggagccct ggttaaaatc ccaaaatacg     3840

gctgaatttg ccttttccca tgtggaatgg agctatcatc ttggcatgtc attcgataag     3900

gatttatatt tagtaactac ggggagtcct cttgatttga aaattcctgt acaaacaaaa     3960

gcattaatgc acttaatgaa aaaaaatctt tgcatgataa attaacatct taaggggaaa     4020

agaaaaaaaa gcatgttgtg atagaagaaa aaaagattca tggtaaacta tttctatcaa     4080

ttgggccaca ctcaacaatt taaaaaatct gcatttgaag atgtcagtgc atttcaaata     4140

tatttgccat acccaactga aacggaaaac aaaacaaaac aagaacccag agttttctcc     4200

tcatctgtaa ctttcattgt actagaacct tattgaattc ttatggcaag agtctgatta     4260

atgttctctc tccatgtttt acatcattca cagttgtgtc aaaatcaaat attgccagta     4320

tagtaaatta ttcccaacac aatcagtttc atttctatca ccttcagaat gggttgctgt     4380

ttttagcaca aaccatgcag ggttgggtca cctcaaagca ttttcttcag cctggcttgt     4440

actctatagg ggagttggta gtaggtgtgg ggaatctata ggaacaatag agttagctat     4500

gagaactgac ttcacaaaaa gggaaatttc acacacccca atttcagctt ctaaagtgat     4560

atattttaaa agcttcattt gtatccttgt ctgccagtta cacagtatat tactgttcaa     4620

acccagtagg gtctgcaatc gaaaggtgct cttgcagcct gacattcaca aaccaaactg     4680

gtcattctct ttagtgtgat tcagtaaaat ctcagttaat gttttgggaa agggattctg     4740

atttatgaca tttctgattt acaagggctt tccttagaaa atacctttcg gtttgatact     4800

taccactgga aattggttcg atacttacca ctggaaatct ttataaaata tagtgatctg     4860

tttgctatct tggtctcagt catcattata gacaatagaa atacataaag agtttaatga     4920

tacaaaatca atgcttttgt ccctaggtca aataatataa gccactagat tatgtcaata     4980

gatgccaaac acttgtccct tattaaagac tcttttaaag ctggaataaa gaatatcctt     5040

aacatgatac aaggtatcta taactcacca gaaaagcacc agagtcaaaa ccaaatagag     5100

acacctacta ccatttaaca tgattctgga agtcaaaagt tataggaatg tatatataca     5160

cattccagga cccatcctgt aatatgttgt ttcgtcaaga aaagttttaa ttatggtttt     5220

ggcttattga atttttgttt atcaaggtct cattggattt acatttgtgt ttcttaagac     5280

ttcacaattt tcctggattt caggttattt tattagccaa aaaatcgtat ttttatttcc     5340

tttttagtct aattttttgc tagaagttgt actttctagc aaatgtttct agtggtacaa     5400

tgttctcagt aattttgagg agaacaaaga tgagtgaaag agttagataa tgtacactag     5460

gatagcattt ctcagagtcc ttgaatcctc ttgttaagaa agcctctctg aatctcccag     5520

actcctgtga acagccttac ggtaacagaa tctggcttgg aaacacagac attacatgac     5580

tgtataattt atagaattat aaaattatat ggtaaaaata ttaaagaaac ttaagagtag     5640

gatctagaaa atactagtgg ccaaattgca atgtattctt tgtaccatct gtttcaaaga     5700

cttagttttc tgattttcag aacaaatact ttatcgtttc tgtattttaa aaaaaactaa     5760

aagagtaaaa tattagttta ttttagaaat aatgaaattc agtccaaagt agcagtacat     5820

ttgatgagta tttctgaagc cttcaataag atttaacttg ttttaacttg atctacatcg     5880

agatttctca aaagcagcac tattagctga aagtctttgt tgtggggaac tgtcctgtgt     5940

attgtaggat gttagcaaca tccctggcct ctgtctacta gatgccagta agaacctcct     6000

agtaatgaca atcaaaatgt ctccagtcat tgccaaaatt tctcccagtt cacagccact     6060

attctacatc atacaaagag gtagattgtg tgaatatgta atatatgttg ttgtataaaa     6120

ctgtacaata agtatacaat gtcttagcaa gataaattat tatacccaaa attacatgtg     6180

tggttcatat gcaataagat acaattttga agaaagctta taggaatcag tgaaaaataa     6240

caactacaga atattttaag gcacacagag aaaatatcaa aaaggacatt atagcatttc     6300

actgtagaag tgcttaaaac cttggcctca gtgaatagat caaaagttta taattagcac     6360

accaattgga agtaaacagg tgcttctcaa atgcttgaaa agaaaaggct ctttgaagta     6420

gttaaaacgt gtctttcaaa attgctttta taagcccttc cttaacgtaa gggtaacttc     6480

atctcacaaa ctcctggtta gtggaatcca aattaatgag gttttactgt atcaaaatta     6540

tttttataat tcaaagagat gatagcaata agaagaatct aatgtggatg tgatttttct     6600

ctttgaacaa ttctgttctg ttgcactgac cttagcacgc acgcacacac acacacacca     6660

tcgccaccac taccatcatc atcttatcct catctttgga aaataagtac tgttgatcca     6720

tgtaatcctt tgcatagtct catctttact atctttcttc tatttcggaa cataagaaaa     6780

atactcctaa taacttggac aatgatacag aaagtgactc tgagccttag ttaccatcaa     6840

aattacattc tatctgctaa agcgacatca gaagataagg cttgcaaacc acagtcccaa     6900

caagttgacc ttgtctccct atgatttcct tggaagataa ggccttttta gtgttacagt     6960

agaaaatggg ccttttcatt tattcatctg tgagaagcta gaggtatttg tttccctgat     7020

aataacgtga gcaatagtcc ctaccttgaa atcatccatt agtcttggag tttggaggga     7080

ggaatgattg attcctcatt tgttttaatc acctacaaaa gcagtactac tgactttgct     7140

tcttacactt cactgagccc cagactttag ggccccaatc attgtcaaga tcattgtcta     7200

actggaactc tgaaaggaca gtgacagaac tgaatgagat gttttccagt gattcagtca     7260

caaagacaat tttctcagat cttttgaaag tgattctcaa ataaataaat caaaatccaa     7320

ctcctttccc tcaaagtttc tagggatctg aaggaaaagg tttactgttg gagtcccttt     7380

ttatgtgacc catgtaccag ttttaaaggc atcatctata ctttatctac atgaagggat     7440

caccatgact ttgagagaaa aaagaatcag attaggccta acattggttg aagaagatta     7500

aaatagattc ttatattcaa gcagaaggga aaaatgaagc caatctagaa aagtaagcta     7560

aaaatcctct ccttggctta ggatcattgg gtcaaactgg gagtatatct gtgtgattac     7620

aacctgctgc tatgagaaaa aagaattgta acttgaccat gttggctcac acagggcaat     7680

gcaaaagaag tcaaaacatt catatcaggt cttggtatct gtgtcaggag aaacgtggtg     7740

gctttcacag cttcttcacc tctgtcctct gtcatgcaac tccatttttg gctaggtact     7800

atttcacatg cacactgtcc tgggtgccag aaatacttgt ggtgtacttg gtttgagcag     7860

tacctctagt atgcaccatt ccagggaaca tggttgtcaa cataacaagt ttagtgtgtg     7920

tatttgcaga caacatagcc ctgaaagcat gaaatgtaga ataggtaagg tctgtcttag     7980

aaaaggagga ggaagtacca atttggtgca agaagatcgt ggtgaggaag gacatgggag     8040

ccacagtgaa gtgaaagagg ctttaaggaa tcagatgcac agatggatgc tttgatttac     8100

acatttatct agaggagtga ttctcaacct tgactgtaca taagaatcac ctcaggaaat     8160

ttttaaattc ccaattatat taaaatcatt tggagtggga accagacacc aatatttgcg     8220

aaagcctcca aggcggttct aatgtccagc caaagttgat tatcactgct ttatggccaa     8280

ctaaggaaac cttgtttgtc tgccttggct ggtgctccag ccccagttct gagtggtcag     8340

ggaaggcaag atgtaagata tagtaatggt atttattctg tatgtctcac agaacaaaag     8400

catttgagaa tttctgacca ggcagtgctc catcaactct taataatcat ctttgtgata     8460

ttctcctatg tgacttgtcc atcaattatt ccaattcaaa ggtctaggtt ttttttcaat     8520

tgtcttacac atgtgacatc acaagatacc agaagtagca cagtaaattc aagagcatat     8580

aaagctaagt ggaaaactaa ttcttcatat ttagacagtg gaaattctca aaacaatcat     8640

ttgctaaatt aggtccaaat ttattattca ttcttcttct ggaggagaca tgggtaccag     8700

gtacctgttc tgctgtaggt atatttcact ggacttggtc ttagcaaaaa ggaagaacaa     8760

atcttccttt ttgattgtta tctcaatcaa aagctcccag ggccacttgg atttattttc     8820

ttagtctttg gacatgtgtt taaaggaaaa gaatacctgt aacttcctat atgacatcca     8880

gtgccctgaa agggtgctta caccttcaaa aaaggagagt ccagcctatc aaaggcagta     8940

acacataatg agaagaaact cagagttatt gcctttcata ctgctttccc tctgctgttg     9000

gcccaccctt cttgactgca aagccagaaa ataaactaga tggtggtttt ggacaattgt     9060

acacaggaac agaatctcta ataacctata atttttagta cttaattatg tgatgtttta     9120

ttctaggaaa taagaaacag atgacatcat tgatgtatct ttctttcatc ttcagaattt     9180

ttgcatcttt tcagaaaatg acaaattact atttttctgt tgcactcagc aattgtgact     9240

atacttaaca aaattcttgt agtctgtaga gatatcaata aaattgtata tgtttgtaca     9300

ta                                                                    9302


<210>  35
<211>  9230
<212>  DNA
<213>  Homo sapiens

<400>  35
gtgcagcggg gagagcggac ggcgggcggg cgaacaggcg ggagagcgcg gcggcggctg       60

cgggcagagt gtttaaaatg aagaagttta atttccgaaa agttttggat ggcttaactg      120

cctcctcccc tggcagtggt agcagcagtg gcagtaacag tggtggtggg gctggaagtg      180

gttccgtaca tccggcgggg actgcagggg ttctcagaga ggaaattcag gaaactttga      240

cttcggagta tttccagatt tgcaagacag ttcggcatgg ttttcctcat cagcccacag      300

cattagcctt tgatccagtt cagaaaatct tggctattgg gacgagaaca ggtgctatac      360

gaatactcgg gagacctggt gttgattgct attgccaaca tgaaagtggt gcagctgtcc      420

tacagctcca atttttgatc aatgagggtg ccttggtcag tgcaagttca gatgatacac      480

ttcatttgtg gaaccttaga caaaaaaggc cagccatact ccattctctt aaatttaacc      540

gggaacgaat tacttactgt catctacctt tccagagtaa atggctttat gttggaacag      600

aaagaggaaa tacacatatt gtaaatattg aatctttcat tctttctgga tatgttatca      660

tgtggaacaa ggcaattgaa ctatccacta agactcatcc aggtccagtt gtacatttaa      720

gcgatagccc aagagatgaa ggcaaactgc taataggtta tgaaaatggt actgtagtat      780

tctgggactt gaaatctaaa agagcagaac tgagagttta ttatgatgag gctattcatt      840

caattgattg gcatcatgag ggcaaacagt tcatgtgcag ccattcagat ggtagtttga      900

ctttatggaa cctgaaaagc ccaagtcgcc ctttccagac cacaattcca catggaaaaa      960

gtcaaagaga aggaagaaaa tctgaatctt gtaaaccaat tcttaaagta gaatacaaga     1020

cctgcaaaaa cagcgaacca ttcataatat tctctggtgg gctgtcctat gacaaagctt     1080

gtagaagacc aagtttaacc atcatgcatg gaaaagcaat tacagtactt gaaatggatc     1140

atcctattgt tgaatttcta actttatgtg aaacgcccta tccaaatgaa tttcaagaac     1200

cctatgctgt cgtggtactt ctggagaaag atctcattgt agttgatctg acacaaagca     1260

attttccaat ctttgaaaat ccatatccca tggacattca tgaatcacca gttacatgca     1320

cagcatactt tgcagattgt cctccggatt tgattctagt actgtattct ataggagtca     1380

agcataaaaa acaaggatac agtaataagg agtggccaat cagtggagga gcttggaacc     1440

ttggagcaca aacatatcca gaaattatta ttactggtca tgcagatgga tcaataaaat     1500

tttgggatgc ttctgcaata actctgcaga tgctgtacaa gctaaaaact tcaaaagtgt     1560

ttgaaaaaca gaaggtagga gaaggaaaac aaacatgtga aattgtagag gaagacccat     1620

ttgccattca gatgatttac tggtgtccag agagcagaat attctgtgta tcaggagtct     1680

ctgcatatgt cataatttat aaattcagca gacatgaaat tacaacagaa atagtgtcat     1740

tagaggtacg acttcagtat gatgttgaag atattattac ccctgaacca gaaacaagtc     1800

ctccgtttcc agatctctca gcccagcttc cttcttcaag gagtctttct gggagcacta     1860

acactgttgc tagtgaagga gtaacaaagg acagtattcc atgcctcaat gtgaagacac     1920

ggccagtgcg aatgcctcca ggatatcaag cagaacttgt tattcaattg gtgtgggtag     1980

atggtgaacc tccacaacag attactagtc ttgctgtaag ctcagcatat ggaatagttg     2040

catttgggaa ctgcaatggg ttggctgtgg tggattttat acagaagaca gtactgttaa     2100

gcatggggac cattgaccta tatagatcaa gtgacttata ccagcgacaa ccacggtctc     2160

ctcgaaaaaa caaacagttc attgcaggtt taactgaact gaatgacagt ccagttcccc     2220

tagaacttga gcgctgcaag tctcctacct cagaccatgt aaatggacac tgcacaagtc     2280

caacttctca gagttgcagt tctggaaaac gtctttctag tgccgatgtt tcaaaagtaa     2340

atcgctgggg tcctggaaga ccaccatttc gaaaggccca gtcagcagcc tgcatggaga     2400

tttctttacc agttacaaca gaagaaaacc gagaaaattc ctataatcgt tctagaagct     2460

ctagtatctc cagtattgac aaagattcta aagaagcaat tacagcacta tacttcatgg     2520

actcctttgc acggaaaaat gactctacca tctctccttg tctgttcgtt ggaaccagtc     2580

tgggaatggt gttaatcatc tccttaaacc taccattagc agatgaacaa aggtttacag     2640

agccagtcat ggtattgcca agtggtacat tcctctcatt gaaaggagct gtgctaacat     2700

tctcctgtat ggaccgaatg ggtggattaa tgcaaccgcc atatgaagtt tggagggatc     2760

caaacaacat agatgaaaat gaaaaatctt ggagaaggaa agtggtaatg aactcatctt     2820

ctgcatccca agaaatagga gatcatcagt atacaataat ctgctcagaa aaacaagcca     2880

aagtcttctc actgccttct cagacttgcc tttatgttca taacatcacg gagacatctt     2940

ttatactgca agcaaatgtg gtggtcatgt gtagcagtgc ctgcttggca tgcttttgtg     3000

ctaacggaca tatcatgata atgagcctac ctagtcttcg cccaatgttg gatgttaatt     3060

atttgccact gacagacatg aggatagcac gaacattttg ttttaccaat gaaggacagg     3120

cattatacct cgtctctcct actgaaattc agcggttaac atacagccaa gaaatgtgtg     3180

ataatctaca ggacatgcta ggagatttgt ttactcccat agagacacca gaagctcaaa     3240

acagaggctt tctcaaggga ctgtttggtg gaagcggaca aacatttgac agagaagagc     3300

tctttgggga agcttcggca ggaaaagcat cccgcagcct tgcgcaacac attcctggac     3360

caggtagtat agaagggatg aaaggcgctg ctggaggggt gatgggagag ctgacccgtg     3420

cacggattgc acttgatgaa agaggacaga ggctaggaga gctggaagag aaaactgcag     3480

gcatgatgac cagtgcagaa gcattttcca aacatgcaca tgagttaatg ctgaaataca     3540

aggataagaa atggtaccaa ttctgacttc taaagaagct gtgactgctt tgagaaacca     3600

tattcaggga aaccaaattt attcccagca tcactactca actgctagaa gccagtttct     3660

tctacaaaat gttccattta cagtcaatct gaaattttca taaaagagat gtatcagaga     3720

cactgtgcaa cccaaaggct ggagccctgg ttaaaatccc aaaatacggc tgaatttgcc     3780

ttttcccatg tggaatggag ctatcatctt ggcatgtcat tcgataagga tttatattta     3840

gtaactacgg ggagtcctct tgatttgaaa attcctgtac aaacaaaagc attaatgcac     3900

ttaatgaaaa aaaatctttg catgataaat taacatctta aggggaaaag aaaaaaaagc     3960

atgttgtgat agaagaaaaa aagattcatg gtaaactatt tctatcaatt gggccacact     4020

caacaattta aaaaatctgc atttgaagat gtcagtgcat ttcaaatata tttgccatac     4080

ccaactgaaa cggaaaacaa aacaaaacaa gaacccagag ttttctcctc atctgtaact     4140

ttcattgtac tagaacctta ttgaattctt atggcaagag tctgattaat gttctctctc     4200

catgttttac atcattcaca gttgtgtcaa aatcaaatat tgccagtata gtaaattatt     4260

cccaacacaa tcagtttcat ttctatcacc ttcagaatgg gttgctgttt ttagcacaaa     4320

ccatgcaggg ttgggtcacc tcaaagcatt ttcttcagcc tggcttgtac tctatagggg     4380

agttggtagt aggtgtgggg aatctatagg aacaatagag ttagctatga gaactgactt     4440

cacaaaaagg gaaatttcac acaccccaat ttcagcttct aaagtgatat attttaaaag     4500

cttcatttgt atccttgtct gccagttaca cagtatatta ctgttcaaac ccagtagggt     4560

ctgcaatcga aaggtgctct tgcagcctga cattcacaaa ccaaactggt cattctcttt     4620

agtgtgattc agtaaaatct cagttaatgt tttgggaaag ggattctgat ttatgacatt     4680

tctgatttac aagggctttc cttagaaaat acctttcggt ttgatactta ccactggaaa     4740

ttggttcgat acttaccact ggaaatcttt ataaaatata gtgatctgtt tgctatcttg     4800

gtctcagtca tcattataga caatagaaat acataaagag tttaatgata caaaatcaat     4860

gcttttgtcc ctaggtcaaa taatataagc cactagatta tgtcaataga tgccaaacac     4920

ttgtccctta ttaaagactc ttttaaagct ggaataaaga atatccttaa catgatacaa     4980

ggtatctata actcaccaga aaagcaccag agtcaaaacc aaatagagac acctactacc     5040

atttaacatg attctggaag tcaaaagtta taggaatgta tatatacaca ttccaggacc     5100

catcctgtaa tatgttgttt cgtcaagaaa agttttaatt atggttttgg cttattgaat     5160

ttttgtttat caaggtctca ttggatttac atttgtgttt cttaagactt cacaattttc     5220

ctggatttca ggttatttta ttagccaaaa aatcgtattt ttatttcctt tttagtctaa     5280

ttttttgcta gaagttgtac tttctagcaa atgtttctag tggtacaatg ttctcagtaa     5340

ttttgaggag aacaaagatg agtgaaagag ttagataatg tacactagga tagcatttct     5400

cagagtcctt gaatcctctt gttaagaaag cctctctgaa tctcccagac tcctgtgaac     5460

agccttacgg taacagaatc tggcttggaa acacagacat tacatgactg tataatttat     5520

agaattataa aattatatgg taaaaatatt aaagaaactt aagagtagga tctagaaaat     5580

actagtggcc aaattgcaat gtattctttg taccatctgt ttcaaagact tagttttctg     5640

attttcagaa caaatacttt atcgtttctg tattttaaaa aaaactaaaa gagtaaaata     5700

ttagtttatt ttagaaataa tgaaattcag tccaaagtag cagtacattt gatgagtatt     5760

tctgaagcct tcaataagat ttaacttgtt ttaacttgat ctacatcgag atttctcaaa     5820

agcagcacta ttagctgaaa gtctttgttg tggggaactg tcctgtgtat tgtaggatgt     5880

tagcaacatc cctggcctct gtctactaga tgccagtaag aacctcctag taatgacaat     5940

caaaatgtct ccagtcattg ccaaaatttc tcccagttca cagccactat tctacatcat     6000

acaaagaggt agattgtgtg aatatgtaat atatgttgtt gtataaaact gtacaataag     6060

tatacaatgt cttagcaaga taaattatta tacccaaaat tacatgtgtg gttcatatgc     6120

aataagatac aattttgaag aaagcttata ggaatcagtg aaaaataaca actacagaat     6180

attttaaggc acacagagaa aatatcaaaa aggacattat agcatttcac tgtagaagtg     6240

cttaaaacct tggcctcagt gaatagatca aaagtttata attagcacac caattggaag     6300

taaacaggtg cttctcaaat gcttgaaaag aaaaggctct ttgaagtagt taaaacgtgt     6360

ctttcaaaat tgcttttata agcccttcct taacgtaagg gtaacttcat ctcacaaact     6420

cctggttagt ggaatccaaa ttaatgaggt tttactgtat caaaattatt tttataattc     6480

aaagagatga tagcaataag aagaatctaa tgtggatgtg atttttctct ttgaacaatt     6540

ctgttctgtt gcactgacct tagcacgcac gcacacacac acacaccatc gccaccacta     6600

ccatcatcat cttatcctca tctttggaaa ataagtactg ttgatccatg taatcctttg     6660

catagtctca tctttactat ctttcttcta tttcggaaca taagaaaaat actcctaata     6720

acttggacaa tgatacagaa agtgactctg agccttagtt accatcaaaa ttacattcta     6780

tctgctaaag cgacatcaga agataaggct tgcaaaccac agtcccaaca agttgacctt     6840

gtctccctat gatttccttg gaagataagg cctttttagt gttacagtag aaaatgggcc     6900

ttttcattta ttcatctgtg agaagctaga ggtatttgtt tccctgataa taacgtgagc     6960

aatagtccct accttgaaat catccattag tcttggagtt tggagggagg aatgattgat     7020

tcctcatttg ttttaatcac ctacaaaagc agtactactg actttgcttc ttacacttca     7080

ctgagcccca gactttaggg ccccaatcat tgtcaagatc attgtctaac tggaactctg     7140

aaaggacagt gacagaactg aatgagatgt tttccagtga ttcagtcaca aagacaattt     7200

tctcagatct tttgaaagtg attctcaaat aaataaatca aaatccaact cctttccctc     7260

aaagtttcta gggatctgaa ggaaaaggtt tactgttgga gtcccttttt atgtgaccca     7320

tgtaccagtt ttaaaggcat catctatact ttatctacat gaagggatca ccatgacttt     7380

gagagaaaaa agaatcagat taggcctaac attggttgaa gaagattaaa atagattctt     7440

atattcaagc agaagggaaa aatgaagcca atctagaaaa gtaagctaaa aatcctctcc     7500

ttggcttagg atcattgggt caaactggga gtatatctgt gtgattacaa cctgctgcta     7560

tgagaaaaaa gaattgtaac ttgaccatgt tggctcacac agggcaatgc aaaagaagtc     7620

aaaacattca tatcaggtct tggtatctgt gtcaggagaa acgtggtggc tttcacagct     7680

tcttcacctc tgtcctctgt catgcaactc catttttggc taggtactat ttcacatgca     7740

cactgtcctg ggtgccagaa atacttgtgg tgtacttggt ttgagcagta cctctagtat     7800

gcaccattcc agggaacatg gttgtcaaca taacaagttt agtgtgtgta tttgcagaca     7860

acatagccct gaaagcatga aatgtagaat aggtaaggtc tgtcttagaa aaggaggagg     7920

aagtaccaat ttggtgcaag aagatcgtgg tgaggaagga catgggagcc acagtgaagt     7980

gaaagaggct ttaaggaatc agatgcacag atggatgctt tgatttacac atttatctag     8040

aggagtgatt ctcaaccttg actgtacata agaatcacct caggaaattt ttaaattccc     8100

aattatatta aaatcatttg gagtgggaac cagacaccaa tatttgcgaa agcctccaag     8160

gcggttctaa tgtccagcca aagttgatta tcactgcttt atggccaact aaggaaacct     8220

tgtttgtctg ccttggctgg tgctccagcc ccagttctga gtggtcaggg aaggcaagat     8280

gtaagatata gtaatggtat ttattctgta tgtctcacag aacaaaagca tttgagaatt     8340

tctgaccagg cagtgctcca tcaactctta ataatcatct ttgtgatatt ctcctatgtg     8400

acttgtccat caattattcc aattcaaagg tctaggtttt ttttcaattg tcttacacat     8460

gtgacatcac aagataccag aagtagcaca gtaaattcaa gagcatataa agctaagtgg     8520

aaaactaatt cttcatattt agacagtgga aattctcaaa acaatcattt gctaaattag     8580

gtccaaattt attattcatt cttcttctgg aggagacatg ggtaccaggt acctgttctg     8640

ctgtaggtat atttcactgg acttggtctt agcaaaaagg aagaacaaat cttccttttt     8700

gattgttatc tcaatcaaaa gctcccaggg ccacttggat ttattttctt agtctttgga     8760

catgtgttta aaggaaaaga atacctgtaa cttcctatat gacatccagt gccctgaaag     8820

ggtgcttaca ccttcaaaaa aggagagtcc agcctatcaa aggcagtaac acataatgag     8880

aagaaactca gagttattgc ctttcatact gctttccctc tgctgttggc ccacccttct     8940

tgactgcaaa gccagaaaat aaactagatg gtggttttgg acaattgtac acaggaacag     9000

aatctctaat aacctataat ttttagtact taattatgtg atgttttatt ctaggaaata     9060

agaaacagat gacatcattg atgtatcttt ctttcatctt cagaattttt gcatcttttc     9120

agaaaatgac aaattactat ttttctgttg cactcagcaa ttgtgactat acttaacaaa     9180

attcttgtag tctgtagaga tatcaataaa attgtatatg tttgtacata                9230


<210>  36
<211>  9248
<212>  DNA
<213>  Homo sapiens

<400>  36
ccaacgtcgt ttttctgaaa ataaaatact ctgagccgaa cgtttcgaag aaggaaagtc       60

cgcccttaag agagagacag agtcttgtgt ttaaaatgaa gaagtttaat ttccgaaaag      120

ttttggatgg cttaactgcc tcctcccctg gcagtggtag cagcagtggc agtaacagtg      180

gtggtggggc tggaagtggt tccgtacatc cggcggggac tgcaggggtt ctcagagagg      240

aaattcagga aactttgact tcggagtatt tccagatttg caagacagtt cggcatggtt      300

ttcctcatca gcccacagca ttagcctttg atccagttca gaaaatcttg gctattggga      360

cgagaacagg tgctatacga atactcggga gacctggtgt tgattgctat tgccaacatg      420

aaagtggtgc agctgtccta cagctccaat ttttgatcaa tgagggtgcc ttggtcagtg      480

caagttcaga tgatacactt catttgtgga accttagaca aaaaaggcca gccatactcc      540

attctcttaa atttaaccgg gaacgaatta cttactgtca tctacctttc cagagtaaat      600

ggctttatgt tggaacagaa agaggaaata cacatattgt aaatattgaa tctttcattc      660

tttctggata tgttatcatg tggaacaagg caattgaact atccactaag actcatccag      720

gtccagttgt acatttaagc gatagcccaa gagatgaagg caaactgcta ataggttatg      780

aaaatggtac tgtagtattc tgggacttga aatctaaaag agcagaactg agagtttatt      840

atgatgaggc tattcattca attgattggc atcatgaggg caaacagttc atgtgcagcc      900

attcagatgg tagtttgact ttatggaacc tgaaaagccc aagtcgccct ttccagacca      960

caattccaca tggaaaaagt caaagagaag gaagaaaatc tgaatcttgt aaaccaattc     1020

ttaaagtaga atacaagacc tgcaaaaaca gcgaaccatt cataatattc tctggtgggc     1080

tgtcctatga caaagcttgt agaagaccaa gtttaaccat catgcatgga aaagcaatta     1140

cagtacttga aatggatcat cctattgttg aatttctaac tttatgtgaa acgccctatc     1200

caaatgaatt tcaagaaccc tatgctgtcg tggtacttct ggagaaagat ctcattgtag     1260

ttgatctgac acaaagcaat tttccaatct ttgaaaatcc atatcccatg gacattcatg     1320

aatcaccagt tacatgcaca gcatactttg cagattgtcc tccggatttg attctagtac     1380

tgtattctat aggagtcaag cataaaaaac aaggatacag taataaggag tggccaatca     1440

gtggaggagc ttggaacctt ggagcacaaa catatccaga aattattatt actggtcatg     1500

cagatggatc aataaaattt tgggatgctt ctgcaataac tctgcagatg ctgtacaagc     1560

taaaaacttc aaaagtgttt gaaaaacaga aggtaggaga aggaaaacaa acatgtgaaa     1620

ttgtagagga agacccattt gccattcaga tgatttactg gtgtccagag agcagaatat     1680

tctgtgtatc aggagtctct gcatatgtca taatttataa attcagcaga catgaaatta     1740

caacagaaat agtgtcatta gaggtacgac ttcagtatga tgttgaagat attattaccc     1800

ctgaaccaga aacaagtcct ccgtttccag atctctcagc ccagcttcct tcttcaagga     1860

gtctttctgg gagcactaac actgttgcta gtgaaggagt aacaaaggac agtattccat     1920

gcctcaatgt gaagacacgg ccagtgcgaa tgcctccagg atatcaagca gaacttgtta     1980

ttcaattggt gtgggtagat ggtgaacctc cacaacagat tactagtctt gctgtaagct     2040

cagcatatgg aatagttgca tttgggaact gcaatgggtt ggctgtggtg gattttatac     2100

agaagacagt actgttaagc atggggacca ttgacctata tagatcaagt gacttatacc     2160

agcgacaacc acggtctcct cgaaaaaaca aacagttcat tgcaggttta actgaactga     2220

atgacagtcc agttccccta gaacttgagc gctgcaagtc tcctacctca gaccatgtaa     2280

atggacactg cacaagtcca acttctcaga gttgcagttc tggaaaacgt ctttctagtg     2340

ccgatgtttc aaaagtaaat cgctggggtc ctggaagacc accatttcga aaggcccagt     2400

cagcagcctg catggagatt tctttaccag ttacaacaga agaaaaccga gaaaattcct     2460

ataatcgttc tagaagctct agtatctcca gtattgacaa agattctaaa gaagcaatta     2520

cagcactata cttcatggac tcctttgcac ggaaaaatga ctctaccatc tctccttgtc     2580

tgttcgttgg aaccagtctg ggaatggtgt taatcatctc cttaaaccta ccattagcag     2640

atgaacaaag gtttacagag ccagtcatgg tattgccaag tggtacattc ctctcattga     2700

aaggagctgt gctaacattc tcctgtatgg accgaatggg tggattaatg caaccgccat     2760

atgaagtttg gagggatcca aacaacatag atgaaaatga aaaatcttgg agaaggaaag     2820

tggtaatgaa ctcatcttct gcatcccaag aaataggaga tcatcagtat acaataatct     2880

gctcagaaaa acaagccaaa gtcttctcac tgccttctca gacttgcctt tatgttcata     2940

acatcacgga gacatctttt atactgcaag caaatgtggt ggtcatgtgt agcagtgcct     3000

gcttggcatg cttttgtgct aacggacata tcatgataat gagcctacct agtcttcgcc     3060

caatgttgga tgttaattat ttgccactga cagacatgag gatagcacga acattttgtt     3120

ttaccaatga aggacaggca ttatacctcg tctctcctac tgaaattcag cggttaacat     3180

acagccaaga aatgtgtgat aatctacagg acatgctagg agatttgttt actcccatag     3240

agacaccaga agctcaaaac agaggctttc tcaagggact gtttggtgga agcggacaaa     3300

catttgacag agaagagctc tttggggaag cttcggcagg aaaagcatcc cgcagccttg     3360

cgcaacacat tcctggacca ggtagtatag aagggatgaa aggcgctgct ggaggggtga     3420

tgggagagct gacccgtgca cggattgcac ttgatgaaag aggacagagg ctaggagagc     3480

tggaagagaa aactgcaggc atgatgacca gtgcagaagc attttccaaa catgcacatg     3540

agttaatgct gaaatacaag gataagaaat ggtaccaatt ctgacttcta aagaagctgt     3600

gactgctttg agaaaccata ttcagggaaa ccaaatttat tcccagcatc actactcaac     3660

tgctagaagc cagtttcttc tacaaaatgt tccatttaca gtcaatctga aattttcata     3720

aaagagatgt atcagagaca ctgtgcaacc caaaggctgg agccctggtt aaaatcccaa     3780

aatacggctg aatttgcctt ttcccatgtg gaatggagct atcatcttgg catgtcattc     3840

gataaggatt tatatttagt aactacgggg agtcctcttg atttgaaaat tcctgtacaa     3900

acaaaagcat taatgcactt aatgaaaaaa aatctttgca tgataaatta acatcttaag     3960

gggaaaagaa aaaaaagcat gttgtgatag aagaaaaaaa gattcatggt aaactatttc     4020

tatcaattgg gccacactca acaatttaaa aaatctgcat ttgaagatgt cagtgcattt     4080

caaatatatt tgccataccc aactgaaacg gaaaacaaaa caaaacaaga acccagagtt     4140

ttctcctcat ctgtaacttt cattgtacta gaaccttatt gaattcttat ggcaagagtc     4200

tgattaatgt tctctctcca tgttttacat cattcacagt tgtgtcaaaa tcaaatattg     4260

ccagtatagt aaattattcc caacacaatc agtttcattt ctatcacctt cagaatgggt     4320

tgctgttttt agcacaaacc atgcagggtt gggtcacctc aaagcatttt cttcagcctg     4380

gcttgtactc tataggggag ttggtagtag gtgtggggaa tctataggaa caatagagtt     4440

agctatgaga actgacttca caaaaaggga aatttcacac accccaattt cagcttctaa     4500

agtgatatat tttaaaagct tcatttgtat ccttgtctgc cagttacaca gtatattact     4560

gttcaaaccc agtagggtct gcaatcgaaa ggtgctcttg cagcctgaca ttcacaaacc     4620

aaactggtca ttctctttag tgtgattcag taaaatctca gttaatgttt tgggaaaggg     4680

attctgattt atgacatttc tgatttacaa gggctttcct tagaaaatac ctttcggttt     4740

gatacttacc actggaaatt ggttcgatac ttaccactgg aaatctttat aaaatatagt     4800

gatctgtttg ctatcttggt ctcagtcatc attatagaca atagaaatac ataaagagtt     4860

taatgataca aaatcaatgc ttttgtccct aggtcaaata atataagcca ctagattatg     4920

tcaatagatg ccaaacactt gtcccttatt aaagactctt ttaaagctgg aataaagaat     4980

atccttaaca tgatacaagg tatctataac tcaccagaaa agcaccagag tcaaaaccaa     5040

atagagacac ctactaccat ttaacatgat tctggaagtc aaaagttata ggaatgtata     5100

tatacacatt ccaggaccca tcctgtaata tgttgtttcg tcaagaaaag ttttaattat     5160

ggttttggct tattgaattt ttgtttatca aggtctcatt ggatttacat ttgtgtttct     5220

taagacttca caattttcct ggatttcagg ttattttatt agccaaaaaa tcgtattttt     5280

atttcctttt tagtctaatt ttttgctaga agttgtactt tctagcaaat gtttctagtg     5340

gtacaatgtt ctcagtaatt ttgaggagaa caaagatgag tgaaagagtt agataatgta     5400

cactaggata gcatttctca gagtccttga atcctcttgt taagaaagcc tctctgaatc     5460

tcccagactc ctgtgaacag ccttacggta acagaatctg gcttggaaac acagacatta     5520

catgactgta taatttatag aattataaaa ttatatggta aaaatattaa agaaacttaa     5580

gagtaggatc tagaaaatac tagtggccaa attgcaatgt attctttgta ccatctgttt     5640

caaagactta gttttctgat tttcagaaca aatactttat cgtttctgta ttttaaaaaa     5700

aactaaaaga gtaaaatatt agtttatttt agaaataatg aaattcagtc caaagtagca     5760

gtacatttga tgagtatttc tgaagccttc aataagattt aacttgtttt aacttgatct     5820

acatcgagat ttctcaaaag cagcactatt agctgaaagt ctttgttgtg gggaactgtc     5880

ctgtgtattg taggatgtta gcaacatccc tggcctctgt ctactagatg ccagtaagaa     5940

cctcctagta atgacaatca aaatgtctcc agtcattgcc aaaatttctc ccagttcaca     6000

gccactattc tacatcatac aaagaggtag attgtgtgaa tatgtaatat atgttgttgt     6060

ataaaactgt acaataagta tacaatgtct tagcaagata aattattata cccaaaatta     6120

catgtgtggt tcatatgcaa taagatacaa ttttgaagaa agcttatagg aatcagtgaa     6180

aaataacaac tacagaatat tttaaggcac acagagaaaa tatcaaaaag gacattatag     6240

catttcactg tagaagtgct taaaaccttg gcctcagtga atagatcaaa agtttataat     6300

tagcacacca attggaagta aacaggtgct tctcaaatgc ttgaaaagaa aaggctcttt     6360

gaagtagtta aaacgtgtct ttcaaaattg cttttataag cccttcctta acgtaagggt     6420

aacttcatct cacaaactcc tggttagtgg aatccaaatt aatgaggttt tactgtatca     6480

aaattatttt tataattcaa agagatgata gcaataagaa gaatctaatg tggatgtgat     6540

ttttctcttt gaacaattct gttctgttgc actgacctta gcacgcacgc acacacacac     6600

acaccatcgc caccactacc atcatcatct tatcctcatc tttggaaaat aagtactgtt     6660

gatccatgta atcctttgca tagtctcatc tttactatct ttcttctatt tcggaacata     6720

agaaaaatac tcctaataac ttggacaatg atacagaaag tgactctgag ccttagttac     6780

catcaaaatt acattctatc tgctaaagcg acatcagaag ataaggcttg caaaccacag     6840

tcccaacaag ttgaccttgt ctccctatga tttccttgga agataaggcc tttttagtgt     6900

tacagtagaa aatgggcctt ttcatttatt catctgtgag aagctagagg tatttgtttc     6960

cctgataata acgtgagcaa tagtccctac cttgaaatca tccattagtc ttggagtttg     7020

gagggaggaa tgattgattc ctcatttgtt ttaatcacct acaaaagcag tactactgac     7080

tttgcttctt acacttcact gagccccaga ctttagggcc ccaatcattg tcaagatcat     7140

tgtctaactg gaactctgaa aggacagtga cagaactgaa tgagatgttt tccagtgatt     7200

cagtcacaaa gacaattttc tcagatcttt tgaaagtgat tctcaaataa ataaatcaaa     7260

atccaactcc tttccctcaa agtttctagg gatctgaagg aaaaggttta ctgttggagt     7320

ccctttttat gtgacccatg taccagtttt aaaggcatca tctatacttt atctacatga     7380

agggatcacc atgactttga gagaaaaaag aatcagatta ggcctaacat tggttgaaga     7440

agattaaaat agattcttat attcaagcag aagggaaaaa tgaagccaat ctagaaaagt     7500

aagctaaaaa tcctctcctt ggcttaggat cattgggtca aactgggagt atatctgtgt     7560

gattacaacc tgctgctatg agaaaaaaga attgtaactt gaccatgttg gctcacacag     7620

ggcaatgcaa aagaagtcaa aacattcata tcaggtcttg gtatctgtgt caggagaaac     7680

gtggtggctt tcacagcttc ttcacctctg tcctctgtca tgcaactcca tttttggcta     7740

ggtactattt cacatgcaca ctgtcctggg tgccagaaat acttgtggtg tacttggttt     7800

gagcagtacc tctagtatgc accattccag ggaacatggt tgtcaacata acaagtttag     7860

tgtgtgtatt tgcagacaac atagccctga aagcatgaaa tgtagaatag gtaaggtctg     7920

tcttagaaaa ggaggaggaa gtaccaattt ggtgcaagaa gatcgtggtg aggaaggaca     7980

tgggagccac agtgaagtga aagaggcttt aaggaatcag atgcacagat ggatgctttg     8040

atttacacat ttatctagag gagtgattct caaccttgac tgtacataag aatcacctca     8100

ggaaattttt aaattcccaa ttatattaaa atcatttgga gtgggaacca gacaccaata     8160

tttgcgaaag cctccaaggc ggttctaatg tccagccaaa gttgattatc actgctttat     8220

ggccaactaa ggaaaccttg tttgtctgcc ttggctggtg ctccagcccc agttctgagt     8280

ggtcagggaa ggcaagatgt aagatatagt aatggtattt attctgtatg tctcacagaa     8340

caaaagcatt tgagaatttc tgaccaggca gtgctccatc aactcttaat aatcatcttt     8400

gtgatattct cctatgtgac ttgtccatca attattccaa ttcaaaggtc taggtttttt     8460

ttcaattgtc ttacacatgt gacatcacaa gataccagaa gtagcacagt aaattcaaga     8520

gcatataaag ctaagtggaa aactaattct tcatatttag acagtggaaa ttctcaaaac     8580

aatcatttgc taaattaggt ccaaatttat tattcattct tcttctggag gagacatggg     8640

taccaggtac ctgttctgct gtaggtatat ttcactggac ttggtcttag caaaaaggaa     8700

gaacaaatct tcctttttga ttgttatctc aatcaaaagc tcccagggcc acttggattt     8760

attttcttag tctttggaca tgtgtttaaa ggaaaagaat acctgtaact tcctatatga     8820

catccagtgc cctgaaaggg tgcttacacc ttcaaaaaag gagagtccag cctatcaaag     8880

gcagtaacac ataatgagaa gaaactcaga gttattgcct ttcatactgc tttccctctg     8940

ctgttggccc acccttcttg actgcaaagc cagaaaataa actagatggt ggttttggac     9000

aattgtacac aggaacagaa tctctaataa cctataattt ttagtactta attatgtgat     9060

gttttattct aggaaataag aaacagatga catcattgat gtatctttct ttcatcttca     9120

gaatttttgc atcttttcag aaaatgacaa attactattt ttctgttgca ctcagcaatt     9180

gtgactatac ttaacaaaat tcttgtagtc tgtagagata tcaataaaat tgtatatgtt     9240

tgtacata                                                              9248


<210>  37
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu 
                325                 330                 335     


Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu 
            340                 345                 350         


Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu 
        355                 360                 365             


Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln 
    370                 375                 380                 


Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu 
385                 390                 395                 400 


Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser 
                405                 410                 415     


Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly 
            420                 425                 430         


Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg 
        435                 440                 445             


Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro 
    450                 455                 460                 


Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn Gly 
465                 470                 475                 480 


Gly Ser Asp Ala Gln Asp Gly Asn Gln Pro Gln His Asn Gly Glu Ser 
                485                 490                 495     


Asn Glu Asp Ser Lys Asp Asn His Glu Ala Ser Thr Lys Lys Lys Pro 
            500                 505                 510         


Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr Leu 
        515                 520                 525             


Asp Asn 
    530 


<210>  38
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu His Gln Thr Thr Cys Asn Leu Gln 
                325                 330             


<210>  39
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu His Phe Ala Leu 
                325                 


<210>  40
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  40
cgggcccggt agctgggccc gcgtccgccg cccgcatccc cgcgccgccg catctcctcg       60

ccgcctcccg ggcttcggac ccccggtctc gcccccgaaa catgactcgc gatttcaaac      120

ctggagacct catcttcgcc aagatgaaag gttatcccca ttggccagct cgagtagacg      180

aagttcctga tggagctgta aagccaccca caaacaaact acccattttc ttttttggaa      240

ctcatgagac tgctttttta ggaccaaagg atatatttcc ttactcagaa aataaggaaa      300

agtatggcaa accaaataaa agaaaaggtt ttaatgaagg tttatgggag atagataaca      360

atccaaaagt gaaattttca agtcaacagg cagcaactaa acaatcaaat gcatcatctg      420

atgttgaagt tgaagaaaag gaaactagtg tttcaaagga agataccgac catgaagaaa      480

aagccagcaa tgaggatgtg actaaagcag ttgacataac tactccaaaa gctgccagaa      540

gggggagaaa gagaaaggca gaaaaacaag tagaaactga ggaggcagga gtagtgacaa      600

cagcaacagc atctgttaat ctaaaagtga gtcctaaaag aggacgacct gcagctacag      660

aagtcaagat tccaaaacca agaggcagac ccaaaatggt aaaacagccc tgtccttcag      720

agagtgacat cattactgaa gaggacaaaa gtaagaaaaa ggggcaagag gaaaaacaac      780

ctaaaaagca gcctaagaag gatgaagagg gccagaagga agaagataag ccaagaaaag      840

agccggataa aaaagagggg aagaaagaag ttgaatcaaa aaggaaaaat ttagctaaaa      900

caggggttac ttcaacctcc gattctgaag aagaaggaga tgatcaagaa ggtgaaaaga      960

agagaaaagg tgggaggaac tttcagactg ctcacagaag gaatatgctg aaaggccaac     1020

atgagaaaga agcagcagat cgaaaacgca agcaagagga acaaatggaa actgagcacc     1080

aaacaacatg taatctacag taataaaaaa tatatctcat tttgggctca aagcattaat     1140

ccagttactg aaaagagaat acaagtggag caaacaagag atgaagatct tgatacagac     1200

tcattggact gaatttcccc cttcccccca ttgatggaag aatgttccag attctaaatt     1260

gaggacttca ttattaatgg cattactgtg ttatgattaa caaatttcct gtaaggtaca     1320

cactacatac taaggtcggc catcattcct gttttttttt tttttttttt tttttaacca     1380

agcttaaaat gaagctttgt gtttgaaagt aataacaagc tcagacgaag atggtggttg     1440

tacattattc atctagaaaa tataaaaatt cattttgttt tgaagctagt tattaaactg     1500

gaatagcagt tatatccctg agaatggggc ccttctcttg acattccttt gttgtttaat     1560

tctttagaat cttaataaat gtttttttaa tcctgagaga ttaaacagta gtagacttgt     1620

taagaatgaa actgtaacca aaattttaaa ataaagtttt ttttaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa                                                            1690


<210>  41
<211>  3410
<212>  DNA
<213>  Homo sapiens

<400>  41
agttggtcgc gccccagtgc tagcgggcgc cgagcgggag ccgcgcggga gcagcgcagc       60

tacggcggcg gcagcggcgg cgcggttgcg attccgagcc gttgagacgc ctctgcggca      120

gctggtggcg caggtggctt gcgtggacgc gggtagaggc gaccggccag caaccgcagc      180

gtcggcgccc gcggccccgg cagcaggcgc gtcgggacgc cccgaggcat cctcccccgc      240

ccgcgggccc ggtagctggg cccgcgtccg ccgcccgcat ccccgcgccg ccgcatctcc      300

tcgccgcctc ccgggcttcg gacccccggt ctcgcccccg aaacatgact cgcgatttca      360

aacctggaga cctcatcttc gccaagatga aaggttatcc ccattggcca gctcgagtag      420

acgaagttcc tgatggagct gtaaagccac ccacaaacaa actacccatt ttcttttttg      480

gaactcatga gactgctttt ttaggaccaa aggatatatt tccttactca gaaaataagg      540

aaaagtatgg caaaccaaat aaaagaaaag gttttaatga aggtttatgg gagatagata      600

acaatccaaa agtgaaattt tcaagtcaac aggcagcaac taaacaatca aatgcatcat      660

ctgatgttga agttgaagaa aaggaaacta gtgtttcaaa ggaagatacc gaccatgaag      720

aaaaagccag caatgaggat gtgactaaag cagttgacat aactactcca aaagctgcca      780

gaagggggag aaagagaaag gcagaaaaac aagtagaaac tgaggaggca ggagtagtga      840

caacagcaac agcatctgtt aatctaaaag tgagtcctaa aagaggacga cctgcagcta      900

cagaagtcaa gattccaaaa ccaagaggca gacccaaaat ggtaaaacag ccctgtcctt      960

cagagagtga catcattact gaagaggaca aaagtaagaa aaaggggcaa gaggaaaaac     1020

aacctaaaaa gcagcctaag aaggatgaag agggccagaa ggaagaagat aagccaagaa     1080

aagagccgga taaaaaagag gggaagaaag aagttgaatc aaaaaggaaa aatttagcta     1140

aaacaggggt tacttcaacc tccgattctg aagaagaagg agatgatcaa gaaggtgaaa     1200

agaagagaaa aggtgggagg aactttcaga ctgctcacag aaggaatatg ctgaaaggcc     1260

aacatgagaa agaagcagca gatcgaaaac gcaagcaaga ggaacaaatg gaaactgagc     1320

agcagaataa agatgaagga aagaagccag aagttaagaa agtggagaag aagcgagaaa     1380

catcaatgga ttctcgactt caaaggatac atgctgagat taaaaattca ctcaaaattg     1440

ataatcttga tgtgaacaga tgcattgagg ccttggatga acttgcttca cttcaggtca     1500

caatgcaaca agctcagaaa cacacagaga tgattactac actgaaaaaa atacggcgat     1560

tcaaagttag tcaggtaatc atggaaaagt ctacaatgtt gtataacaag tttaagaaca     1620

tgttcttggt tggtgaagga gattccgtga tcacccaagt gctgaataaa tctcttgctg     1680

aacaaagaca gcatgaggaa gcgaataaaa ccaaagatca agggaagaaa gggccaaaca     1740

aaaagctaga gaaggaacaa acagggtcaa agactctaaa tggaggatct gatgctcaag     1800

atggtaatca gccacaacat aacggggaga gcaatgaaga cagcaaagac aaccatgaag     1860

ccagcacgaa gaaaaagcca tccagtgaag agagagagac tgaaatatct ctgaaggatt     1920

ctacactaga taactaggtt gacatacctg gaatatagag aacacttgag aagtttgtaa     1980

tggttttcat ttgaaataga ctgctgaaag ttttaaattt ttataagcat aggtttgatg     2040

ttgaaaactt gttttgaggg agaaaatccc tttgttttaa agtaaagtaa acattatcgc     2100

taagtgtact tgtgcagtat taacagctac attatacagt aaatgtggga taaaatccat     2160

ttagaaaatg ttaaactgct tttccagaca tggttgtagc atattttcaa ttagtgtgtg     2220

tatgttaatg tgtaattgat agtagaacaa agttacattt ttaaaactgc tacttgtata     2280

aaccttgcct cttttcccaa atactgtggg ttttgtgcat agtttttaca aaccttggat     2340

ttaccagact gtcttttcac tgtttgtggg ttttgtagaa gttacacatt tttatggtag     2400

ataaaatgtt acttctatac aagtactcac tcccttttta tcaaaagtta attttaatct     2460

cacagtctac attgtgctac attatccagc ttctttggaa caatgtgtgc tctgtatggt     2520

tttttttggt atgacaacta attaagcaac tgacatggaa ctgagaattc tacaaactat     2580

aaaacattaa tttttgaagg taatttagtt ttgtggctgg gcattcagtg aagtcttagg     2640

acttctttgc agacaactga ctgggtatat ataggaatga atctggcttt agggttaaat     2700

catttaaggt ccttttatag gcaggcacta gtaactaaaa ctgaaaacta agtaagttta     2760

tttttgagga atgttgttaa aaatgtcttt aggaagtcac taaaacttaa ttggaagaaa     2820

aaatcatgat gcttatacaa taaatatgaa taaatgttat ataaggaaac tcacctattt     2880

gaaatcatgg ctatattgtt tttattttct agattccaaa aatacaaaca ctagttgttc     2940

cagcattgta ctttgataag tctgtacatt gacgtgtatg gactaaatcc agggtaaaat     3000

caatgttaca aaatttaagg gtatgttaac taaaggatag catttctaag atattttgaa     3060

tattagggtc atttggcact tctcagcaag taggatactt ctcatgtttt gaaattatat     3120

gaatatggaa aaaaatggct taagaccagc gtctctgtat gacattgtgt ggttgaccct     3180

ctgagataac tgttttcatc tacagaattg catttttgct tttaaagagg tcttataatg     3240

gaactaggaa tcaccgtttt gagagaacct gcatatatac cagtcattat ctgtttggtc     3300

cttatacagt tttaacttac ttagatttat tctagttaag ccataagttc aacgtgtaaa     3360

cttgttttca ttaaagaatt tttctatcaa aaaaaaaaaa aaaaaaaaaa                3410


<210>  42
<211>  3407
<212>  DNA
<213>  Homo sapiens

<400>  42
agttggtcgc gccccagtgc tagcgggcgc cgagcgggag ccgcgcggga gcagcgcagc       60

tacggcggcg gcagcggcgg cgcggttgcg attccgagcc gttgagacgc ctctgcggca      120

gctggtggcg caggtggctt gcgtggacgc gggtagaggc gaccggccag caaccgcagc      180

gtcggcgccc gcggccccgg caggcgcgtc gggacgcccc gaggcatcct cccccgcccg      240

cgggcccggt agctgggccc gcgtccgccg cccgcatccc cgcgccgccg catctcctcg      300

ccgcctcccg ggcttcggac ccccggtctc gcccccgaaa catgactcgc gatttcaaac      360

ctggagacct catcttcgcc aagatgaaag gttatcccca ttggccagct cgagtagacg      420

aagttcctga tggagctgta aagccaccca caaacaaact acccattttc ttttttggaa      480

ctcatgagac tgctttttta ggaccaaagg atatatttcc ttactcagaa aataaggaaa      540

agtatggcaa accaaataaa agaaaaggtt ttaatgaagg tttatgggag atagataaca      600

atccaaaagt gaaattttca agtcaacagg cagcaactaa acaatcaaat gcatcatctg      660

atgttgaagt tgaagaaaag gaaactagtg tttcaaagga agataccgac catgaagaaa      720

aagccagcaa tgaggatgtg actaaagcag ttgacataac tactccaaaa gctgccagaa      780

gggggagaaa gagaaaggca gaaaaacaag tagaaactga ggaggcagga gtagtgacaa      840

cagcaacagc atctgttaat ctaaaagtga gtcctaaaag aggacgacct gcagctacag      900

aagtcaagat tccaaaacca agaggcagac ccaaaatggt aaaacagccc tgtccttcag      960

agagtgacat cattactgaa gaggacaaaa gtaagaaaaa ggggcaagag gaaaaacaac     1020

ctaaaaagca gcctaagaag gatgaagagg gccagaagga agaagataag ccaagaaaag     1080

agccggataa aaaagagggg aagaaagaag ttgaatcaaa aaggaaaaat ttagctaaaa     1140

caggggttac ttcaacctcc gattctgaag aagaaggaga tgatcaagaa ggtgaaaaga     1200

agagaaaagg tgggaggaac tttcagactg ctcacagaag gaatatgctg aaaggccaac     1260

atgagaaaga agcagcagat cgaaaacgca agcaagagga acaaatggaa actgagcagc     1320

agaataaaga tgaaggaaag aagccagaag ttaagaaagt ggagaagaag cgagaaacat     1380

caatggattc tcgacttcaa aggatacatg ctgagattaa aaattcactc aaaattgata     1440

atcttgatgt gaacagatgc attgaggcct tggatgaact tgcttcactt caggtcacaa     1500

tgcaacaagc tcagaaacac acagagatga ttactacact gaaaaaaata cggcgattca     1560

aagttagtca ggtaatcatg gaaaagtcta caatgttgta taacaagttt aagaacatgt     1620

tcttggttgg tgaaggagat tccgtgatca cccaagtgct gaataaatct cttgctgaac     1680

aaagacagca tgaggaagcg aataaaacca aagatcaagg gaagaaaggg ccaaacaaaa     1740

agctagagaa ggaacaaaca gggtcaaaga ctctaaatgg aggatctgat gctcaagatg     1800

gtaatcagcc acaacataac ggggagagca atgaagacag caaagacaac catgaagcca     1860

gcacgaagaa aaagccatcc agtgaagaga gagagactga aatatctctg aaggattcta     1920

cactagataa ctaggttgac atacctggaa tatagagaac acttgagaag tttgtaatgg     1980

ttttcatttg aaatagactg ctgaaagttt taaattttta taagcatagg tttgatgttg     2040

aaaacttgtt ttgagggaga aaatcccttt gttttaaagt aaagtaaaca ttatcgctaa     2100

gtgtacttgt gcagtattaa cagctacatt atacagtaaa tgtgggataa aatccattta     2160

gaaaatgtta aactgctttt ccagacatgg ttgtagcata ttttcaatta gtgtgtgtat     2220

gttaatgtgt aattgatagt agaacaaagt tacattttta aaactgctac ttgtataaac     2280

cttgcctctt ttcccaaata ctgtgggttt tgtgcatagt ttttacaaac cttggattta     2340

ccagactgtc ttttcactgt ttgtgggttt tgtagaagtt acacattttt atggtagata     2400

aaatgttact tctatacaag tactcactcc ctttttatca aaagttaatt ttaatctcac     2460

agtctacatt gtgctacatt atccagcttc tttggaacaa tgtgtgctct gtatggtttt     2520

ttttggtatg acaactaatt aagcaactga catggaactg agaattctac aaactataaa     2580

acattaattt ttgaaggtaa tttagttttg tggctgggca ttcagtgaag tcttaggact     2640

tctttgcaga caactgactg ggtatatata ggaatgaatc tggctttagg gttaaatcat     2700

ttaaggtcct tttataggca ggcactagta actaaaactg aaaactaagt aagtttattt     2760

ttgaggaatg ttgttaaaaa tgtctttagg aagtcactaa aacttaattg gaagaaaaaa     2820

tcatgatgct tatacaataa atatgaataa atgttatata aggaaactca cctatttgaa     2880

atcatggcta tattgttttt attttctaga ttccaaaaat acaaacacta gttgttccag     2940

cattgtactt tgataagtct gtacattgac gtgtatggac taaatccagg gtaaaatcaa     3000

tgttacaaaa tttaagggta tgttaactaa aggatagcat ttctaagata ttttgaatat     3060

tagggtcatt tggcacttct cagcaagtag gatacttctc atgttttgaa attatatgaa     3120

tatggaaaaa aatggcttaa gaccagcgtc tctgtatgac attgtgtggt tgaccctctg     3180

agataactgt tttcatctac agaattgcat ttttgctttt aaagaggtct tataatggaa     3240

ctaggaatca ccgttttgag agaacctgca tatataccag tcattatctg tttggtcctt     3300

atacagtttt aacttactta gatttattct agttaagcca taagttcaac gtgtaaactt     3360

gttttcatta aagaattttt ctatcaaaaa aaaaaaaaaa aaaaaaa                   3407


<210>  43
<211>  2014
<212>  DNA
<213>  Homo sapiens

<400>  43
agttggtcgc gccccagtgc tagcgggcgc cgagcgggag ccgcgcggga gcagcgcagc       60

tacggcggcg gcagcggcgg cgcggttgcg attccgagcc gttgagacgc ctctgcggca      120

gctggtggcg caggtggctt gcgtggacgc gggtagaggc gaccggccag caaccgcagc      180

gtcggcgccc gcggccccgg caggcgcgtc gggacgcccc gaggcatcct cccccgcccg      240

cgggcccggt agctgggccc gcgtccgccg cccgcatccc cgcgccgccg catctcctcg      300

ccgcctcccg ggcttcggac ccccggtctc gcccccgaaa catgactcgc gatttcaaac      360

ctggagacct catcttcgcc aagatgaaag gttatcccca ttggccagct cgagtagacg      420

aagttcctga tggagctgta aagccaccca caaacaaact acccattttc ttttttggaa      480

ctcatgagac tgctttttta ggaccaaagg atatatttcc ttactcagaa aataaggaaa      540

agtatggcaa accaaataaa agaaaaggtt ttaatgaagg tttatgggag atagataaca      600

atccaaaagt gaaattttca agtcaacagg cagcaactaa acaatcaaat gcatcatctg      660

atgttgaagt tgaagaaaag gaaactagtg tttcaaagga agataccgac catgaagaaa      720

aagccagcaa tgaggatgtg actaaagcag ttgacataac tactccaaaa gctgccagaa      780

gggggagaaa gagaaaggca gaaaaacaag tagaaactga ggaggcagga gtagtgacaa      840

cagcaacagc atctgttaat ctaaaagtga gtcctaaaag aggacgacct gcagctacag      900

aagtcaagat tccaaaacca agaggcagac ccaaaatggt aaaacagccc tgtccttcag      960

agagtgacat cattactgaa gaggacaaaa gtaagaaaaa ggggcaagag gaaaaacaac     1020

ctaaaaagca gcctaagaag gatgaagagg gccagaagga agaagataag ccaagaaaag     1080

agccggataa aaaagagggg aagaaagaag ttgaatcaaa aaggaaaaat ttagctaaaa     1140

caggggttac ttcaacctcc gattctgaag aagaaggaga tgatcaagaa ggtgaaaaga     1200

agagaaaagg tgggaggaac tttcagactg ctcacagaag gaatatgctg aaaggccaac     1260

atgagaaaga agcagcagat cgaaaacgca agcaagagga acaaatggaa actgagcatt     1320

ttgctctgta aagcatttca gatgcagctt gtgtgaaatg cattatgcaa aataaagttt     1380

attgtattgt attcccagcc aaacaacatg taatctacag taataaaaaa tatatctcat     1440

tttgggctca aagcattaat ccagttactg aaaagagaat acaagtggag caaacaagag     1500

atgaagatct tgatacagac tcattggact gaatttcccc cttcccccca ttgatggaag     1560

aatgttccag attctaaatt gaggacttca ttattaatgg cattactgtg ttatgattaa     1620

caaatttcct gtaaggtaca cactacatac taaggtcggc catcattcct gttttttttt     1680

tttttttttt tttttaacca agcttaaaat gaagctttgt gtttgaaagt aataacaagc     1740

tcagacgaag atggtggttg tacattattc atctagaaaa tataaaaatt cattttgttt     1800

tgaagctagt tattaaactg gaatagcagt tatatccctg agaatggggc ccttctcttg     1860

acattccttt gttgtttaat tctttagaat cttaataaat gtttttttaa tcctgagaga     1920

ttaaacagta gtagacttgt taagaatgaa actgtaacca aaattttaaa ataaagtttt     1980

ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                                 2014


<210>  44
<211>  1903
<212>  DNA
<213>  Homo sapiens

<400>  44
agttggtcgc gccccagtgc tagcgggcgc cgagcgggag ccgcgcggga gcagcgcagc       60

tacggcggcg gcagcggcgg cgcggttgcg attccgagcc gttgagacgc ctctgcggca      120

gctggtggcg caggtggctt gcgtggacgc gggtagaggc gaccggccag caaccgcagc      180

gtcggcgccc gcggccccgg caggcgcgtc gggacgcccc gaggcatcct cccccgcccg      240

cgggcccggt agctgggccc gcgtccgccg cccgcatccc cgcgccgccg catctcctcg      300

ccgcctcccg ggcttcggac ccccggtctc gcccccgaaa catgactcgc gatttcaaac      360

ctggagacct catcttcgcc aagatgaaag gttatcccca ttggccagct cgagtagacg      420

aagttcctga tggagctgta aagccaccca caaacaaact acccattttc ttttttggaa      480

ctcatgagac tgctttttta ggaccaaagg atatatttcc ttactcagaa aataaggaaa      540

agtatggcaa accaaataaa agaaaaggtt ttaatgaagg tttatgggag atagataaca      600

atccaaaagt gaaattttca agtcaacagg cagcaactaa acaatcaaat gcatcatctg      660

atgttgaagt tgaagaaaag gaaactagtg tttcaaagga agataccgac catgaagaaa      720

aagccagcaa tgaggatgtg actaaagcag ttgacataac tactccaaaa gctgccagaa      780

gggggagaaa gagaaaggca ggagtagtga caacagcaac agcatctgtt aatctaaaag      840

tgagtcctaa aagaggacga cctgcagcta cagaagtcaa gattccaaaa ccaagaggca      900

gacccaaaat ggtaaaacag ccctgtcctt cagagagtga catcattact gaagaggaca      960

aaagtaagaa aaaggggcaa gaggaaaaac aacctaaaaa gcagcctaag aaggatgaag     1020

agggccagaa ggaagaagat aagccaagaa aagagccgga taaaaaagag gggaagaaag     1080

aagttgaatc aaaaaggaaa aatttagcta aaacaggggt tacttcaacc tccgattctg     1140

aagaagaagg agatgatcaa gaaggtgaaa agaagagaaa aggtgggagg aactttcaga     1200

ctgctcacag aaggaatatg ctgaaaggcc aacatgagaa agaagcagca gatcgaaaac     1260

gcaagcaaga ggaacaaatg gaaactgagc accaaacaac atgtaatcta cagtaataaa     1320

aaatatatct cattttgggc tcaaagcatt aatccagtta ctgaaaagag aatacaagtg     1380

gagcaaacaa gagatgaaga tcttgataca gactcattgg actgaatttc ccccttcccc     1440

ccattgatgg aagaatgttc cagattctaa attgaggact tcattattaa tggcattact     1500

gtgttatgat taacaaattt cctgtaaggt acacactaca tactaaggtc ggccatcatt     1560

cctgtttttt tttttttttt ttttttttaa ccaagcttaa aatgaagctt tgtgtttgaa     1620

agtaataaca agctcagacg aagatggtgg ttgtacatta ttcatctaga aaatataaaa     1680

attcattttg ttttgaagct agttattaaa ctggaatagc agttatatcc ctgagaatgg     1740

ggcccttctc ttgacattcc tttgttgttt aattctttag aatcttaata aatgtttttt     1800

taatcctgag agattaaaca gtagtagact tgttaagaat gaaactgtaa ccaaaatttt     1860

aaaataaagt tttttttaaa aaaaaaaaaa aaaaaaaaaa aaa                       1903


<210>  45
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ile Ser Ser Lys Met Met Ser Ser Asn Pro Glu Glu Asp Pro Leu 
1               5                   10                  15      


Asp Thr Phe Leu Gln Tyr Ile Glu Asp Met Gly Met Lys Ala Tyr Asp 
            20                  25                  30          


Gly Leu Val Ile Gln Asn Ala Ser Asp Ile Ala Arg Glu Asn Asp Arg 
        35                  40                  45              


Leu Arg Asn Glu Thr Asn Leu Ala Tyr Leu Lys Glu Lys Asn Glu Lys 
    50                  55                  60                  


Arg Arg Arg Gln Glu Glu Ala Ile Lys Arg Ile Gly Gly Glu Val Gly 
65                  70                  75                  80  


Arg Gly His Glu Gly Ser Tyr Val Gly Lys His Phe Arg Met Gly Phe 
                85                  90                  95      


Met Thr Met Pro Ala Pro Gln Asp Arg Leu Pro His Pro Cys Ser Ser 
            100                 105                 110         


Gly Phe Ser Val Arg Ser Gln Ser Leu His Ser Val Gly Gly Thr Asp 
        115                 120                 125             


Asp Asp Ser Ser Cys Gly Ser Arg Arg Gln Pro Pro Pro Lys Pro Lys 
    130                 135                 140                 


Arg Asp Pro Ser Thr Lys Leu Ser Thr Ser Ser Glu Thr Val Ser Ser 
145                 150                 155                 160 


Thr Ala Ala Ser Lys Ser Gly Lys Thr Pro Glu Arg Thr Glu Ala Ser 
                165                 170                 175     


Ala Lys Pro Arg Pro His Ser Asp Glu Tyr Ser Lys Lys Ile Pro Pro 
            180                 185                 190         


Pro Lys Pro Lys Arg Asn Pro Asn Thr Gln Leu Ser Thr Ser Phe Asp 
        195                 200                 205             


Glu Thr Tyr Ile Lys Lys His Gly Pro Arg Arg Thr Ser Leu Pro Arg 
    210                 215                 220                 


Asp Ser Ser Leu Ser Gln Met Gly Ser Pro Ala Gly Asp Pro Glu Glu 
225                 230                 235                 240 


Glu Glu Pro Val Tyr Ile Glu Met Val Gly Asn Ile Leu Arg Asp Phe 
                245                 250                 255     


Arg Lys Glu Asp Asp Asp Gln Ser Glu Ala Val Tyr Glu Glu Met Lys 
            260                 265                 270         


Tyr Pro Ile Phe Asp Asp Leu Gly Gln Asp Ala Lys Cys Asp Phe Asp 
        275                 280                 285             


His His Ser Cys Ser Ser Gln Cys Ala Thr Pro Thr Val Pro Asp Leu 
    290                 295                 300                 


Asp Phe Ala Lys Ala Ser Val Pro Cys Pro Pro Lys Gly Leu Leu Cys 
305                 310                 315                 320 


Asp Ile Pro Pro Pro Phe Pro Asn Leu Leu Ser His Arg Pro Pro Leu 
                325                 330                 335     


Leu Val Phe Pro Pro Ala Pro Val His Cys Ser Pro Asn Ser Asp Glu 
            340                 345                 350         


Ser Pro Leu Thr Pro Leu Glu Val Thr Lys Leu Pro Val Leu Glu Asn 
        355                 360                 365             


Val Ser Tyr Met Lys Gln Pro Ala Gly Ala Ser Pro Ser Thr Leu Pro 
    370                 375                 380                 


Ser His Val Pro Gly His Ala Lys Leu Glu Lys Glu Gln Ala Ala Ala 
385                 390                 395                 400 


Leu Gly Pro Ala Ser Ala Thr Pro Ala Leu Ser Ser Ser Pro Pro Pro 
                405                 410                 415     


Pro Ser Thr Leu Tyr Arg Thr Gln Ser Pro His Gly Tyr Pro Lys Ser 
            420                 425                 430         


His Ser Thr Ser Pro Ser Pro Val Ser Met Gly Arg Ser Leu Thr Pro 
        435                 440                 445             


Leu Ser Leu Lys Arg Pro Pro Pro Tyr Asp Ala Val His Ser Gly Ser 
    450                 455                 460                 


Leu Ser Arg Ser Ser Pro Ser Val Pro His Ser Thr Pro Arg Pro Val 
465                 470                 475                 480 


Ser Gln Asp Gly Ala Lys Met Val Asn Ala Ala Val Asn Thr Tyr Gly 
                485                 490                 495     


Ala Ala Pro Gly Gly Ser Arg Ser Arg Thr Pro Thr Ser Pro Leu Glu 
            500                 505                 510         


Glu Leu Thr Ser Leu Phe Ser Ser Gly Arg Ser Leu Leu Arg Lys Ser 
        515                 520                 525             


Ser Ser Gly Arg Arg Ser Lys Glu Pro Ala Glu Lys Ser Thr Glu Glu 
    530                 535                 540                 


Leu Lys Val Arg Ser His Ser Thr Glu Pro Leu Pro Lys Leu Asp Asn 
545                 550                 555                 560 


Lys Glu Arg Gly His His Gly Ala Ser Ser Ser Arg Glu Pro Val Lys 
                565                 570                 575     


Ala Gln Glu Trp Asp Gly Thr Pro Gly Thr Pro Val Val Thr Ser Arg 
            580                 585                 590         


Leu Gly Arg Cys Ser Val Ser Pro Thr Leu Leu Ala Gly Asn His Ser 
        595                 600                 605             


Ser Glu Pro Lys Val Ser Cys Lys Leu Gly Arg Ser Ala Ser Thr Ser 
    610                 615                 620                 


Gly Val Pro Pro Pro Ser Val Thr Pro Leu Arg Gln Ser Ser Asp Leu 
625                 630                 635                 640 


Gln Gln Ser Gln Val Pro Ser Ser Leu Ala Asn Arg Asp 
                645                 650             


<210>  46
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ile Ser Ser Lys Met Met Ser Ser Asn Pro Glu Glu Asp Pro Leu 
1               5                   10                  15      


Asp Thr Phe Leu Gln Tyr Ile Glu Asp Met Gly Met Lys Ala Tyr Asp 
            20                  25                  30          


Gly Leu Val Ile Gln Asn Ala Ser Asp Ile Ala Arg Glu Asn Asp Arg 
        35                  40                  45              


Leu Arg Asn Glu Thr Asn Leu Ala Tyr Leu Lys Glu Lys Asn Glu Lys 
    50                  55                  60                  


Arg Arg Arg Gln Glu Glu Ala Ile Lys Arg Ile Asn Arg Gly Thr Glu 
65                  70                  75                  80  


Ser Pro Lys Pro Gln His Gly Ala Ile Thr Lys Val Gly Gln Gln Gly 
                85                  90                  95      


Lys Arg Pro Pro Trp Gly Val Phe Leu Gln Arg Ala Cys Gln Ser Ser 
            100                 105                 110         


Gly Met Gly Trp Asn Thr Arg Ala Thr Cys Gly His Gln Ser Thr Arg 
        115                 120                 125             


Lys Met Leu Cys Glu Pro His Leu Val Ser Gly Lys Pro Gln Phe Arg 
    130                 135                 140                 


Ala 
145 


<210>  47
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Val Asn Ala Ala Val Asn Thr Tyr Gly Ala Ala Pro Gly Gly Ser 
1               5                   10                  15      


Arg Ser Arg Thr Pro Thr Ser Pro Leu Glu Glu Leu Thr Ser Leu Phe 
            20                  25                  30          


Ser Ser Gly Arg Ser Leu Leu Arg Lys Ser Ser Ser Gly Arg Arg Ser 
        35                  40                  45              


Lys Glu Pro Ala Glu Lys Ser Thr Glu Glu Leu Lys Val Arg Ser His 
    50                  55                  60                  


Ser Thr Glu Pro Leu Pro Lys Leu Asp Asn Lys Glu Arg Gly His His 
65                  70                  75                  80  


Gly Ala Ser Ser Ser Arg Glu Pro Val Lys Ala Gln Glu Trp Asp Gly 
                85                  90                  95      


Thr Pro Gly Thr Pro Val Val Thr Ser Arg Leu Gly Arg Cys Ser Val 
            100                 105                 110         


Ser Pro Thr Leu Leu Ala Gly Asn His Ser Ser Glu Pro Lys Val Ser 
        115                 120                 125             


Cys Lys Leu Gly Arg Ser Ala Ser Thr Ser Gly Val Pro Pro Pro Ser 
    130                 135                 140                 


Val Thr Pro Leu Arg Gln Ser Ser Asp Leu Gln Gln Ser Gln Ile 
145                 150                 155                 


<210>  48
<211>  4590
<212>  DNA
<213>  Homo sapiens

<400>  48
taattgaaga aacactgagc tgaactacaa gtctatttct tatggtgctg gattactcct       60

acagaactgc cctgagatca accgtgagag agggctctga cagacacaag tcaccttctg      120

gttattgcac ttagctctcc ctggggactt aaattttggc agtgttcctc tttacatgat      180

atcctccaag atgatgagtt ctaatcctga ggaagaccct ttggacacat ttctccagta      240

cattgaggat atggggatga aggcctatga tggcttggtt attcagaatg cgtcagatat      300

tgctcgagag aatgatcgct tgagaaatga aactaaccta gcctatttga aagagaagaa      360

tgaaaaacgc cgaagacaag aagaagcaat aaagcgcata ggtggagaag tagggcgagg      420

ccacgaagga agttacgtgg gcaaacattt ccgcatggga ttcatgacaa tgcctgctcc      480

tcaggacaga cttccccatc cttgctccag tggcttttct gtgagatcac agtccctgca      540

ctcggttggg ggcacagacg atgacagcag ctgtggctca cggagacaac caccacccaa      600

acccaagagg gaccccagca ccaagctgag cacctcatca gagacagtca gcagcactgc      660

agccagtaag agcgggaaaa cccctgagag gactgaagcg tcagctaaac caagacccca      720

cagcgatgaa tattccaaga agattcctcc tcccaaaccg aagcgaaatc cgaacactca      780

gctgagcaca tctttcgatg aaacgtacat caaaaagcat gggccccgga ggacgtcgct      840

gccgcgggac tcctccttgt cccagatggg cagccccgcg ggagaccccg aggaagagga      900

gcccgtgtac atcgagatgg tggggaacat tctcagagac ttcaggaagg aggacgatga      960

ccagagcgag gccgtctacg aggaaatgaa gtaccctatc tttgacgact tgggccaaga     1020

cgccaaatgt gacttcgacc atcacagctg ttcttcgcag tgtgctactc ccacggtgcc     1080

tgacttggac ttcgccaagg cctcagtgcc atgccccccc aaggggctgc tttgcgacat     1140

ccctccgccc ttccccaacc tgctttctca cagacccccg ctgctggtat ttccccccgc     1200

ccccgtgcat tgctccccca actccgacga gtccccgctt acccctctgg aggtcacgaa     1260

gcttcccgtg ctggaaaacg tgtcttacat gaaacagcca gccggggcgt cgccctccac     1320

gctgccgtcc cacgtccccg gccatgcgaa actggagaaa gagcaggccg cggccctggg     1380

acctgcctct gccacccctg cgctctcctc gtcgccccca cccccgtcta cgctgtaccg     1440

aacccagtct ccccatggct accctaaaag tcactccacc tctccctccc ccgtcagcat     1500

ggggaggtcc ctgactcccc tgagcctcaa aaggcctccc ccttacgacg ctgtgcattc     1560

gggcagcctc tcaaggagct ctccttcagt gcctcactcg acccccagac ccgtgtcgca     1620

agatggggcc aagatggtca acgccgcggt gaacacctac ggggcagccc cgggtggctc     1680

ccggtcccgg acacccacga gcccgctgga ggagctgacc agcctcttct cctccggccg     1740

cagcctgctg cgcaagtcgt ccagtggccg gcgctccaaa gagcctgcag agaaatcaac     1800

agaggaactg aaagtccgaa gccacagcac ggagccatta ccaaagttgg acaacaagga     1860

aagaggccac catggggcgt cttcctccag agagcctgtc aaagctcagg aatgggatgg     1920

aacaccaggg acacctgtgg tcaccagtcg actaggaaga tgctctgtga gccccacctt     1980

gttagcggga aaccacagtt cagagcctaa agtaagctgc aaattaggcc ggtctgcgtc     2040

gacgtcaggt gtgcctcctc catcagtcac tcccctcagg caaagcagtg acctgcaaca     2100

gagccaggta ccatcatcgt tagccaatcg tgattgactt cctgtgatac aacttgccaa     2160

atgcttccca cctctgtctg tcctgttgct gtagacaact ttcgcatttg cttttatttt     2220

tctatgtgtg tatgggttag gggatgcggg ggatgagttc tggcagtctg tgttttcatt     2280

tgaaaaagaa tatctttctt ccttgtgatt ggtggtgaaa ctttctttgc tgtttgttac     2340

caaatcgttt ttgtctctgg tttccatcat tctgtaatat aaatgtagta aacttgtact     2400

atatgtattg gcttagtggt tcttttttaa attctttctc tctttcatgt tttgtgtact     2460

tttatactgt ctctgaaaat ttatcaatat ttgataaatt tatctacttt gttttatgta     2520

gatttctttt taaatgtttt gtccagaaca ctcgcacaga tgttgtcaat gaatttgtac     2580

atatttctta gctcttatcc tattatactg taatatttct ggtggtttta tttttattta     2640

gcttggagca tgactgtaag acactgttga atattgatgt ccttataaat attcatatcc     2700

cgattcattt ggattgagta tggcagctag tctttcttct ttcttaggct attgactggc     2760

ctaagacaat ttgactggcc agacaaattg actggccaga taatctagat atttaacaaa     2820

aactgcagat taataaggca acctttaaat gaatgacttt tctctcttat accaacaata     2880

tcagaaatgt tctcagaaag ggaatgtaag tgttcatgca tggtaaatga gatctcaatt     2940

atcacttgga gaaaagagac aagaaataaa ggcataaact gaaatatcat ttaatccttt     3000

acagcataat atgttgctct gatgttcgtt tgggtacgtg gttgtggatg gggaattagt     3060

atggggaaaa atcactacac ataaatgtcc tatctttagc tcacccaata ggaattcaat     3120

acattgactt aatttgtgag gcttaattgt cgttactgtt aagtattata ggtgttaagt     3180

agggtggtgt cattctggaa tgttttctct ctgcttccta gcttcaatct ttgcattcat     3240

gaaactcttc tgaaatagca acttataaaa cactgatgat acctccaagg gaactgccca     3300

ttactgatga gaaaattaca tattcatcta ttattttaaa tgtcaggcta ttttaaaaac     3360

ataactaagt agaataattg cgttttcttc taatgagaga cattgtgcct cttagtgttt     3420

ttgtctgact taaatatgca aaatagttga tttataaata tatgaggtat ctgcaaatac     3480

aagaaatgag aggcttctct caagggtatc tcaagtacca tttagaattt cttgtgtctt     3540

aatttaaaat ttaaatgcct ttatataaat gttaaatgcc tttataacta aatgtaccaa     3600

ctcaaacact ttttggatat aaaagaagta gaaacagtaa gacactgaat aaaataaata     3660

agataaactg ccaacttagc taattaaagc tattccaaaa atattgtact taccaacatt     3720

taaagcttaa aaacattggg tactgaaaga agagaagttt agctaattgg cagaggattg     3780

cactaataca atcaagtttt caagtttatg acccttgcta gtatattacc ttcaatatct     3840

cagagatgtt ttgtattatt tgttttgttt tgcttttttc ctagttgtct ttatagctgt     3900

ttcaccctaa gccccttcaa actctcaatg aaagcaggtt cttgggataa acttccagaa     3960

tagagacaag gtataccctt tgtgcctttg cattatcaac tctttgttca cctgatggga     4020

agttcttcgt ttttcaaaat gtagcaaggg agaaagccca ggacgccttt atatgctgtt     4080

agtttcctta cctgctgata gagattctga cacacagtca aatcatacat gggctgtcag     4140

agctataaat tagaaggctg gcctctaggc ttctcctctg tggcttatag ccagttgtaa     4200

tatacatgca ttcctatact ctagagatga agtggtaagc atagctcata tgaacactgc     4260

tctgaactcc tctgacttag cattcaactt aagtcaagaa atacttattg gctgggcgtg     4320

gtggctcacg cctgtaatcc cagcactctg ggaggcagag gtgggtggat cacaaggtca     4380

ggagattgag accatcctgg ctaacacggt gagaccccat ctctactaaa aatacaaaaa     4440

attagccagg tgtggtggcg ggcgcctgta gtcccagcta cttgggaggc tgaggcagga     4500

gaatgtggtg aacctgggag gtggagcttg cagtgagctg agatcgcacc actgcactcc     4560

agcctgggtg acagagcgag actccatctc                                      4590


<210>  49
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Phe Ala Arg Lys Pro Pro Gly Ala Ala Pro Leu Gly Ala Met Pro 
1               5                   10                  15      


Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Thr Ser Ser Leu Ser 
            20                  25                  30          


Pro Gly Leu Asn Thr Ser Asn Gly Asp Gly Ser Glu Thr Glu Thr Thr 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe Glu Arg 
    50                  55                  60                  


Leu Thr Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser Gln Leu 
65                  70                  75                  80  


Glu Arg Cys Lys Leu Gly Ser Glu Thr Gly Ser Met Ser Ser Met Ser 
                85                  90                  95      


Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln Lys Asp 
            100                 105                 110         


Ile Glu Asp Glu Leu Thr Thr Gly Leu Glu Leu Val Asp Ser Cys Ile 
        115                 120                 125             


Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr Ser Thr 
    130                 135                 140                 


Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala Leu Gln Leu Asn Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser Tyr His Ser Asn Gln 
                165                 170                 175     


Thr Leu Ala Leu Gly Glu Thr Thr Pro Ser Gln Leu Pro Ala Arg Gly 
            180                 185                 190         


Thr Gln Ala Arg Ala Thr Gly Gln Ser Phe Ser Gln Gly Thr Thr Ser 
        195                 200                 205             


Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly Ser Ala Phe His Leu 
225                 230                 235                 240 


Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala Leu Tyr Tyr Ser Ser 
                245                 250                 255     


Ser Thr Leu Pro Ala Pro Pro Arg Gly Gly Ser Pro Leu Ala Ala Pro 
            260                 265                 270         


Gln Gly Gly Ser Pro Thr Lys Leu Gln Arg Gly Gly Ser Ala Pro Glu 
        275                 280                 285             


Gly Ala Thr Tyr Ala Ala Pro Arg Gly Ser Ser Pro Lys Gln Ser Pro 
    290                 295                 300                 


Ser Arg Leu Ala Lys Ser Tyr Ser Thr Ser Ser Pro Ile Asn Ile Val 
305                 310                 315                 320 


Val Ser Ser Ala Gly Leu Ser Pro Ile Arg Val Thr Ser Pro Pro Thr 
                325                 330                 335     


Val Gln Ser Thr Ile Ser Ser Ser Pro Ile His Gln Leu Ser Ser Thr 
            340                 345                 350         


Ile Gly Thr Tyr Ala Thr Leu Ser Pro Thr Lys Arg Leu Val His Ala 
        355                 360                 365             


Ser Glu Gln Tyr Ser Lys His Ser Gln Glu Leu Tyr Ala Thr Ala Thr 
    370                 375                 380                 


Leu Gln Arg Pro Gly Ser Leu Ala Ala Gly Ser Arg Ala Ser Tyr Ser 
385                 390                 395                 400 


Ser Gln His Gly His Leu Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro 
                405                 410                 415     


Glu His His Ile Asp Pro Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro 
            420                 425                 430         


Pro Met Arg Ser Leu Ser Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala 
        435                 440                 445             


His Thr Gly Thr Tyr Arg Thr Ser Thr Ala Pro Ser Ser Pro Gly Val 
    450                 455                 460                 


Asp Ser Val Pro Leu Gln Arg Thr Gly Ser Gln His Gly Pro Gln Asn 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Phe Gln Arg Ala Ser Tyr Ala Ala Gly Pro Ala 
                485                 490                 495     


Ser Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln Tyr Cys Pro Ser Val 
            500                 505                 510         


Glu Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu Pro Pro Glu Gly Thr 
        515                 520                 525             


Leu Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu 
    530                 535                 540                 


Phe Gly Trp Arg Asp Pro Glu Leu Pro Glu Val Ile Gln Met Leu Gln 
545                 550                 555                 560 


His Gln Phe Pro Ser Val Gln Ser Asn Ala Ala Ala Tyr Leu Gln His 
                565                 570                 575     


Leu Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu Ile Arg Arg Gln Gly 
            580                 585                 590         


Gly Ile Gln Leu Leu Val Asp Leu Leu Asp His Arg Met Thr Glu Val 
        595                 600                 605             


His Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu Val Tyr Gly Lys Ala 
    610                 615                 620                 


Asn Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys Gly Gly Ile Pro Ala 
625                 630                 635                 640 


Leu Val Arg Leu Leu Arg Lys Thr Thr Asp Leu Glu Ile Arg Glu Leu 
                645                 650                 655     


Val Thr Gly Val Leu Trp Asn Leu Ser Ser Cys Asp Ala Leu Lys Met 
            660                 665                 670         


Pro Ile Ile Gln Asp Ala Leu Ala Val Leu Thr Asn Ala Val Ile Ile 
        675                 680                 685             


Pro His Ser Gly Trp Glu Asn Ser Pro Leu Gln Asp Asp Arg Lys Ile 
    690                 695                 700                 


Gln Leu His Ser Ser Gln Val Leu Arg Asn Ala Thr Gly Cys Leu Arg 
705                 710                 715                 720 


Asn Val Ser Ser Ala Gly Glu Glu Ala Arg Arg Arg Met Arg Glu Cys 
                725                 730                 735     


Asp Gly Leu Thr Asp Ala Leu Leu Tyr Val Ile Gln Ser Ala Leu Gly 
            740                 745                 750         


Ser Ser Glu Ile Asp Ser Lys Thr Val Glu Asn Cys Val Cys Ile Leu 
        755                 760                 765             


Arg Asn Leu Ser Tyr Arg Leu Ala Ala Glu Thr Ser Gln Gly Gln His 
    770                 775                 780                 


Met Gly Thr Asp Glu Leu Asp Gly Leu Leu Cys Gly Glu Ala Asn Gly 
785                 790                 795                 800 


Lys Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys Lys Lys Lys Lys Lys 
                805                 810                 815     


Lys Ser Gln Asp Gln Trp Asp Gly Val Gly Pro Leu Pro Asp Cys Ala 
            820                 825                 830         


Glu Pro Pro Lys Gly Ile Gln Met Leu Trp His Pro Ser Ile Val Lys 
        835                 840                 845             


Pro Tyr Leu Thr Leu Leu Ser Glu Cys Ser Asn Pro Asp Thr Leu Glu 
    850                 855                 860                 


Gly Ala Ala Gly Ala Leu Gln Asn Leu Ala Ala Gly Ser Trp Lys Trp 
865                 870                 875                 880 


Ser Val Tyr Ile Arg Ala Ala Val Arg Lys Glu Lys Gly Leu Pro Ile 
                885                 890                 895     


Leu Val Glu Leu Leu Arg Ile Asp Asn Asp Arg Val Val Cys Ala Val 
            900                 905                 910         


Ala Thr Ala Leu Arg Asn Met Ala Leu Asp Val Arg Asn Lys Glu Leu 
        915                 920                 925             


Ile Gly Lys Tyr Ala Met Arg Asp Leu Val His Arg Leu Pro Gly Gly 
    930                 935                 940                 


Asn Asn Ser Asn Asn Thr Ala Ser Lys Ala Met Ser Asp Asp Thr Val 
945                 950                 955                 960 


Thr Ala Val Cys Cys Thr Leu His Glu Val Ile Thr Lys Asn Met Glu 
                965                 970                 975     


Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile Glu Lys Leu Val Gly 
            980                 985                 990         


Ile Ser Lys Ser Lys Gly Asp Lys  His Ser Pro Lys Val  Val Lys Ala 
        995                 1000                 1005             


Ala Ser  Gln Val Leu Asn Ser  Met Trp Gln Tyr Arg  Asp Leu Arg 
    1010                 1015                 1020             


Ser Leu  Tyr Lys Lys Asp Gly  Trp Ser Gln Tyr His  Phe Val Ala 
    1025                 1030                 1035             


Ser Ser  Ser Thr Ile Glu Arg  Asp Arg Gln Arg Pro  Tyr Ser Ser 
    1040                 1045                 1050             


Ser Arg  Thr Pro Ser Ile Ser  Pro Val Arg Val Ser  Pro Asn Asn 
    1055                 1060                 1065             


Arg Ser  Ala Ser Ala Pro Ala  Ser Pro Arg Glu Met  Ile Ser Leu 
    1070                 1075                 1080             


Lys Glu  Arg Lys Thr Asp Tyr  Glu Cys Thr Gly Ser  Asn Ala Thr 
    1085                 1090                 1095             


Tyr His  Gly Ala Lys Gly Glu  His Thr Ser Arg Lys  Asp Ala Met 
    1100                 1105                 1110             


Thr Ala  Gln Asn Thr Gly Ile  Ser Thr Leu Tyr Arg  Asn Ser Tyr 
    1115                 1120                 1125             


Gly Ala  Pro Ala Glu Asp Ile  Lys His Asn Gln Val  Ser Ala Gln 
    1130                 1135                 1140             


Pro Val  Pro Gln Glu Pro Ser  Arg Lys Asp Tyr Glu  Thr Tyr Gln 
    1145                 1150                 1155             


Pro Phe  Gln Asn Ser Thr Arg  Asn Tyr Asp Glu Ser  Phe Phe Glu 
    1160                 1165                 1170             


Asp Gln  Val His His Arg Pro  Pro Ala Ser Glu Tyr  Thr Met His 
    1175                 1180                 1185             


Leu Gly  Leu Lys Ser Thr Gly  Asn Tyr Val Asp Phe  Tyr Ser Ala 
    1190                 1195                 1200             


Ala Arg  Pro Tyr Ser Glu Leu  Asn Tyr Glu Thr Ser  His Tyr Pro 
    1205                 1210                 1215             


Ala Ser  Pro Asp Ser Trp Val  
    1220                 1225 


<210>  50
<211>  1167
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Phe Ala Arg Lys Pro Pro Gly Ala Ala Pro Leu Gly Ala Met Pro 
1               5                   10                  15      


Val Pro Asp Gln Pro Ser Ser Ala Ser Glu Lys Thr Ser Ser Leu Ser 
            20                  25                  30          


Pro Gly Leu Asn Thr Ser Asn Gly Asp Gly Ser Glu Thr Glu Thr Thr 
        35                  40                  45              


Ser Ala Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe Glu Arg 
    50                  55                  60                  


Leu Thr Arg Glu Leu Glu Ala Glu Arg Gln Ile Val Ala Ser Gln Leu 
65                  70                  75                  80  


Glu Arg Cys Lys Leu Gly Ser Glu Thr Gly Ser Met Ser Ser Met Ser 
                85                  90                  95      


Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln Asp Gly Gln Lys Asp 
            100                 105                 110         


Ile Glu Asp Glu Leu Thr Thr Gly Leu Glu Leu Val Asp Ser Cys Ile 
        115                 120                 125             


Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro Gln Asp Tyr Ser Thr 
    130                 135                 140                 


Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala Leu Gln Leu Asn Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser Tyr His Ser Asn Gln 
                165                 170                 175     


Thr Leu Ala Leu Gly Glu Thr Thr Pro Ser Gln Leu Pro Ala Arg Gly 
            180                 185                 190         


Thr Gln Ala Arg Ala Thr Gly Gln Ser Phe Ser Gln Gly Thr Thr Ser 
        195                 200                 205             


Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly Ser Ala Phe His Leu 
225                 230                 235                 240 


Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala Leu Tyr Tyr Ser Ser 
                245                 250                 255     


Ser Thr Leu Pro Ala Pro Pro Arg Gly Gly Ser Pro Leu Ala Ala Pro 
            260                 265                 270         


Gln Gly Gly Ser Pro Thr Lys Leu Gln Arg Gly Gly Ser Ala Pro Glu 
        275                 280                 285             


Gly Ala Thr Tyr Ala Ala Pro Arg Gly Ser Ser Pro Lys Gln Ser Pro 
    290                 295                 300                 


Ser Arg Leu Ala Lys Ser Tyr Ser Thr Ser Ser Pro Ile Asn Ile Val 
305                 310                 315                 320 


Val Ser Ser Ala Gly Leu Ser Pro Ile Arg Val Thr Ser Pro Pro Thr 
                325                 330                 335     


Val Gln Ser Thr Ile Ser Ser Ser Pro Ile His Gln Leu Ser Ser Thr 
            340                 345                 350         


Ile Gly Thr Tyr Ala Thr Leu Ser Pro Thr Lys Arg Leu Val His Ala 
        355                 360                 365             


Ser Glu Gln Tyr Ser Lys His Ser Gln Glu Leu Tyr Ala Thr Ala Thr 
    370                 375                 380                 


Leu Gln Arg Pro Gly Ser Leu Ala Ala Gly Ser Arg Ala Ser Tyr Ser 
385                 390                 395                 400 


Ser Gln His Gly His Leu Gly Pro Glu Leu Arg Ala Leu Gln Ser Pro 
                405                 410                 415     


Glu His His Ile Asp Pro Ile Tyr Glu Asp Arg Val Tyr Gln Lys Pro 
            420                 425                 430         


Pro Met Arg Ser Leu Ser Gln Ser Gln Gly Asp Pro Leu Pro Pro Ala 
        435                 440                 445             


His Thr Gly Thr Tyr Arg Thr Ser Thr Ala Pro Ser Ser Pro Gly Val 
    450                 455                 460                 


Asp Ser Val Pro Leu Gln Arg Thr Gly Ser Gln His Gly Pro Gln Asn 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Phe Gln Arg Ala Ser Tyr Ala Ala Gly Pro Ala 
                485                 490                 495     


Ser Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln Tyr Cys Pro Ser Val 
            500                 505                 510         


Glu Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu Pro Pro Glu Gly Thr 
        515                 520                 525             


Leu Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu 
    530                 535                 540                 


Phe Gly Trp Arg Asp Pro Glu Leu Pro Glu Val Ile Gln Met Leu Gln 
545                 550                 555                 560 


His Gln Phe Pro Ser Val Gln Ser Asn Ala Ala Ala Tyr Leu Gln His 
                565                 570                 575     


Leu Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu Ile Arg Arg Gln Gly 
            580                 585                 590         


Gly Ile Gln Leu Leu Val Asp Leu Leu Asp His Arg Met Thr Glu Val 
        595                 600                 605             


His Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu Val Tyr Gly Lys Ala 
    610                 615                 620                 


Asn Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys Gly Gly Ile Pro Ala 
625                 630                 635                 640 


Leu Val Arg Leu Leu Arg Lys Thr Thr Asp Leu Glu Ile Arg Glu Leu 
                645                 650                 655     


Val Thr Gly Val Leu Trp Asn Leu Ser Ser Cys Asp Ala Leu Lys Met 
            660                 665                 670         


Pro Ile Ile Gln Asp Ala Leu Ala Val Leu Thr Asn Ala Val Ile Ile 
        675                 680                 685             


Pro His Ser Gly Trp Glu Asn Ser Pro Leu Gln Asp Asp Arg Lys Ile 
    690                 695                 700                 


Gln Leu His Ser Ser Gln Val Leu Arg Asn Ala Thr Gly Cys Leu Arg 
705                 710                 715                 720 


Asn Val Ser Ser Ala Gly Glu Glu Ala Arg Arg Arg Met Arg Glu Cys 
                725                 730                 735     


Asp Gly Leu Thr Asp Ala Leu Leu Tyr Val Ile Gln Ser Ala Leu Gly 
            740                 745                 750         


Ser Ser Glu Ile Asp Ser Lys Thr Val Glu Asn Cys Val Cys Ile Leu 
        755                 760                 765             


Arg Asn Leu Ser Tyr Arg Leu Ala Ala Glu Thr Ser Gln Gly Gln His 
    770                 775                 780                 


Met Gly Thr Asp Glu Leu Asp Gly Leu Leu Cys Gly Glu Ala Asn Gly 
785                 790                 795                 800 


Lys Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys Lys Lys Lys Lys Lys 
                805                 810                 815     


Lys Ser Gln Asp Gln Trp Ser Val Tyr Ile Arg Ala Ala Val Arg Lys 
            820                 825                 830         


Glu Lys Gly Leu Pro Ile Leu Val Glu Leu Leu Arg Ile Asp Asn Asp 
        835                 840                 845             


Arg Val Val Cys Ala Val Ala Thr Ala Leu Arg Asn Met Ala Leu Asp 
    850                 855                 860                 


Val Arg Asn Lys Glu Leu Ile Gly Lys Tyr Ala Met Arg Asp Leu Val 
865                 870                 875                 880 


His Arg Leu Pro Gly Gly Asn Asn Ser Asn Asn Thr Ala Ser Lys Ala 
                885                 890                 895     


Met Ser Asp Asp Thr Val Thr Ala Val Cys Cys Thr Leu His Glu Val 
            900                 905                 910         


Ile Thr Lys Asn Met Glu Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly 
        915                 920                 925             


Ile Glu Lys Leu Val Gly Ile Ser Lys Ser Lys Gly Asp Lys His Ser 
    930                 935                 940                 


Pro Lys Val Val Lys Ala Ala Ser Gln Val Leu Asn Ser Met Trp Gln 
945                 950                 955                 960 


Tyr Arg Asp Leu Arg Ser Leu Tyr Lys Lys Asp Gly Trp Ser Gln Tyr 
                965                 970                 975     


His Phe Val Ala Ser Ser Ser Thr Ile Glu Arg Asp Arg Gln Arg Pro 
            980                 985                 990         


Tyr Ser Ser Ser Arg Thr Pro Ser  Ile Ser Pro Val Arg  Val Ser Pro 
        995                 1000                 1005             


Asn Asn  Arg Ser Ala Ser Ala  Pro Ala Ser Pro Arg  Glu Met Ile 
    1010                 1015                 1020             


Ser Leu  Lys Glu Arg Lys Thr  Asp Tyr Glu Cys Thr  Gly Ser Asn 
    1025                 1030                 1035             


Ala Thr  Tyr His Gly Ala Lys  Gly Glu His Thr Ser  Arg Lys Asp 
    1040                 1045                 1050             


Ala Met  Thr Ala Gln Asn Thr  Gly Ile Ser Thr Leu  Tyr Arg Asn 
    1055                 1060                 1065             


Ser Tyr  Gly Ala Pro Ala Glu  Asp Ile Lys His Asn  Gln Val Ser 
    1070                 1075                 1080             


Ala Gln  Pro Val Pro Gln Glu  Pro Ser Arg Lys Asp  Tyr Glu Thr 
    1085                 1090                 1095             


Tyr Gln  Pro Phe Gln Asn Ser  Thr Arg Asn Tyr Asp  Glu Ser Phe 
    1100                 1105                 1110             


Phe Glu  Asp Gln Val His His  Arg Pro Pro Ala Ser  Glu Tyr Thr 
    1115                 1120                 1125             


Met His  Leu Gly Leu Lys Ser  Thr Gly Asn Tyr Val  Asp Phe Tyr 
    1130                 1135                 1140             


Ser Ala  Ala Arg Pro Tyr Ser  Glu Leu Asn Tyr Glu  Thr Ser His 
    1145                 1150                 1155             


Tyr Pro  Ala Ser Pro Asp Ser  Trp Val 
    1160                 1165         


<210>  51
<211>  5481
<212>  DNA
<213>  Homo sapiens

<400>  51
gcgtcgggag ccgcctctcg cccgcggcgc tcgcccctgc cgcccgccag catcccttgt       60

cccgcggccg cgctcagaca acaaaagcgg aagatgctgc agttgggcaa ggtcaggacc      120

ttgccctgaa gccgggcggc gccgcgcacg cctcttcccg gactgaggag ctgtcgccgg      180

cggagggtgc atgtttgcga ggaagccgcc gggcgccgcg cctttgggag ctatgcctgt      240

tccagaccag ccttcatcag cctcagagaa gacgagttcc ctgagccccg gcttaaacac      300

ctccaacggg gatggctctg aaacagaaac cacctctgcc atcctcgcct cagtcaaaga      360

acaggaatta cagtttgaaa ggctgacccg agagctggag gctgaacggc agatcgtagc      420

cagccagctg gagcgatgca agctcggatc cgagactggc agcatgagca gcatgagttc      480

agcagaagag cagtttcagt ggcagtcaca agatggtcaa aaagatatcg aagatgagct      540

tacaacaggt ctcgagctgg tggactcctg tattaggtca ctacaggaat caggaatact      600

tgacccacag gattattcta caggtgaaag gcccagcctg ctctcccaga gtgcacttca      660

gctcaattcc aaacctgaag ggtctttcca gtatccggcc agctaccata gcaaccagac      720

cctggccctg ggggaaacca ccccttcaca gctcccggcc cgaggcacac aagcccgagc      780

tacgggccag agcttcagcc agggcacgac cagccgcgcc ggccacctgg cggggcccga      840

gcccgcgccg ccgccgccgc cgccgccgcg ggagccgttc gcgcccagcc tgggcagcgc      900

cttccacctg cccgacgcgc cgcccgccgc cgccgccgcc gcgctctact actccagctc      960

cacgctgccc gcgccgccgc gcgggggctc cccgctggcc gcgccccagg gcggttcgcc     1020

caccaagctg cagcgcggcg gctcggcccc cgagggcgcc acctacgccg cgccgcgcgg     1080

ctcctcgccc aagcagtcgc ccagccgcct ggccaagtcc tacagcacca gctcgcccat     1140

caacatcgtc gtgtcctcgg ccggcctgtc cccgatccgc gtgacctcgc cccccaccgt     1200

gcagtccacc atctcctcct cgcccatcca ccagctgagc tccaccatcg gcacgtacgc     1260

caccctgtcg cccaccaagc gcctggtcca cgcgtccgag cagtacagca agcactcgca     1320

ggagctgtat gccacggcca ccctccagag gccgggcagc ctggcagctg gttcccgagc     1380

ctcatacagc agccagcatg ggcacctggg cccagagttg cgggccctgc agtccccaga     1440

acaccacata gatcccatct atgaagaccg cgtctatcag aagcccccta tgaggagtct     1500

cagccagagc cagggggacc ctctgccgcc agcacacacc ggcacctacc gcacgagcac     1560

agccccatct tcccctggtg tcgactccgt ccccttgcag cgcacaggca gccagcacgg     1620

cccacagaat gccgccgcgg ccaccttcca gagggccagc tatgccgccg gcccagcctc     1680

caattacgcg gacccctacc gacagctgca gtattgtccc tctgttgagt ctccatacag     1740

caaatccggc cctgctctcc cgcctgaagg caccttggcc aggtccccgt ccattgatag     1800

cattcagaaa gatcccagag aatttggatg gagagacccg gaactgccgg aagtgattca     1860

gatgttgcag caccagtttc cctcggtcca gtctaacgcg gcagcctact tgcaacacct     1920

ctgttttgga gacaacaaaa ttaaagccga gataaggaga caaggaggca tccagctcct     1980

ggtggacctg ttggatcatc ggatgaccga agtccaccgt agtgcctgtg gagctctgag     2040

aaacctggtg tatgggaagg ccaacgatga taacaaaatt gccctgaaaa actgtggtgg     2100

catcccagca ctggtgaggt tactccgcaa gacgactgac ctggagatcc gggagctggt     2160

cacaggagtc ctttggaacc tctcctcatg cgatgcactc aaaatgccaa tcatccagga     2220

tgccctagca gtactgacca acgcggtgat tatcccccac tcaggctggg aaaattcgcc     2280

tcttcaggat gatcggaaaa tacagctgca ttcatcacag gtgctgcgta acgccaccgg     2340

gtgcctaagg aatgttagtt cggccggaga ggaggcccgc agaaggatga gagagtgtga     2400

tgggcttacg gatgccttgc tgtacgtgat ccagtctgcg ctggggagca gtgagatcga     2460

tagcaagacc gttgaaaact gtgtgtgcat tttaaggaac ctctcgtacc ggctggcggc     2520

agaaacgtct cagggacagc acatgggcac ggacgagctg gacgggctac tctgtggcga     2580

ggccaatggc aaggatgctg agagctctgg gtgctggggc aagaagaaga agaaaaagaa     2640

atcccaagat cagtgggatg gagtaggacc tcttccagac tgtgctgaac caccaaaagg     2700

gatccagatg ctgtggcacc catcaatagt caaaccctac ctcacactgc tctctgagtg     2760

ctcaaatcca gacacgctgg aaggggcggc aggcgccctg cagaacttgg ctgcagggag     2820

ctggaagtgg tcagtatata tccgagccgc tgtccgaaaa gagaaaggcc tgcccatcct     2880

cgtggagctg ctccgaatag acaatgaccg tgtggtgtgc gcggtggcca ctgcgctgcg     2940

gaacatggcc ttggacgtca gaaataagga gctcatcggc aaatacgcca tgcgagacct     3000

agtccacagg cttccaggag ggaacaacag caacaacact gcaagcaagg ccatgtcgga     3060

tgacacagtg acagctgtct gctgcacact gcacgaagtg attaccaaga acatggagaa     3120

cgccaaggcc ttacgggatg ccggtggcat cgagaagttg gtcggcatct ccaaaagcaa     3180

aggagataaa cactctccaa aagtggtcaa ggctgcatct caggtcctca acagcatgtg     3240

gcagtaccga gatctgagga gtctctacaa aaaggatgga tggtcacaat accactttgt     3300

agcctcgtct tcaaccatcg agagggaccg gcaaaggccc tactcctcct cccgcacgcc     3360

ctccatctcc cctgtgcgcg tgtctcccaa caaccgctca gcaagtgccc cagcttcacc     3420

tcgggaaatg atcagcctca aagaaaggaa aacagactac gagtgcaccg gcagcaacgc     3480

cacctaccac ggagctaaag gcgaacacac ttccaggaaa gatgccatga cagctcaaaa     3540

cactggaatt tcaactttgt ataggaattc ttatggtgcg cccgctgaag acatcaaaca     3600

caaccaggtt tcagcacagc cagtcccaca ggagcccagc agaaaagatt acgagaccta     3660

ccagccattt cagaattcca caagaaatta cgatgagtcc ttcttcgagg accaggtcca     3720

ccatcgccct cccgccagcg agtacaccat gcacctgggt ctcaagtcca ccggcaacta     3780

cgttgacttc tactcagctg cccgtcccta cagtgaactg aactatgaaa cgagccacta     3840

cccggcctcc cccgactcct gggtgtgagg agcagggcac aggcgctccg ggaacagtgc     3900

atgtgcatgc ataccacaag acatttcttt ctgttttgtt tttttctcct gcaaatttag     3960

tttgttaaag cctgttccat aggaaggctg tgataaccag taaggaaata ttaagagcta     4020

ttttagaaag ctaaatgaat cgcaagttaa cttggaaatc agtagaaagc taaagtgatc     4080

ctaaatatga cagtgggcag cacctttcta gcgtgagctg tagagtaacg agaagtgctt     4140

tatactgaac gtggttgatg ggaggagaga cgaggcattc gggccggtgg ggcgtaaggg     4200

ttatcgttaa gcacaagaca cagaatagtt tacacactgt gtgggggacg gcttctcacg     4260

ctttgtttac tctcttcatc cgttgtgact ctaggcttca ggttgcattg gggttcctct     4320

gtacagcaag atgtttcttg ccttttgtta atgcattgtt gtaaagtatt tgatgtacat     4380

tacagattaa agaagaaaag cgcgttgtgt atattacacc aatgccgccg tgtttcctca     4440

tctatggttc taaatattgc ttcaatttca aacttttgaa agatgtatgg atttccagtt     4500

tttctttact ttctcccagt atgttttaac aaaaaaaaaa aaaagcagga aaaaaggaat     4560

atttagcagt attgttcgtt ctgatatgtg aatttgtttg tgacaactaa acaaggcatt     4620

cagcagtttc tgacaattaa catacatcat tccacactcc ttgtcaacaa agtgcttttt     4680

cactgcctaa aattttagat gtagatattt gaaatagatt ttttcattta taccagtttt     4740

ctttatgatg atacagtgtt aaaagaaaat aaattacaat tgatctgtca tccatatttg     4800

ctaagaatgt ctatttccaa gaacctatat cttacaaaat acacattctt gcttgtgtgt     4860

ctgtgtgtgt gggtgtatgt atgtccacgt actagaaaaa ttacctgtgt gagattttat     4920

tttgacagaa gctatttcat ttgctgttca tcttgtacaa actttgtttt tggtttttta     4980

gtataaatgt acatcagttt gttccttttg tactgtatct attcttctga ccatctagtg     5040

actcaggata ttaggccagt tgaagtggag ttataggatt ttcacacatt cacgcatact     5100

tggatatcaa ccctctctac aggtccgttt ccttacacat tttatcccct cagaacacga     5160

taaaccatgg ccaattcagt ttcactttgg ggccaattac ttgaagtatc cacagaaaat     5220

gtaaactgct cgccttattc ccccaaactt tttgttcatg tggcagggag cagtacacaa     5280

ctatggaata gattattaaa actgaacttg aagctaacgt tagaatagtg gttaacagag     5340

ctaagaaata aggctaacca tcgaaaagaa catgggccgc gggtaaacta gctttgctct     5400

ttagatgcaa gtggctgagg ccaataggtg cctagtaaat gttaactgtt cttggaaaaa     5460

ataaaaacat cagtaacaaa a                                               5481


<210>  52
<211>  5289
<212>  DNA
<213>  Homo sapiens

<400>  52
gttcctttta gccgtggtgc agggagggag gagggaggtg ggtaggatgc caggaaccgc       60

ctgctccaca gcctggggaa ggagggaaga gtaacccttc atctttggga ctagtcgtct      120

tgtttgccta gactacagtt ttcaagtatt taaggaccat ttatttcaaa aggaattaca      180

gtttgaaagg ctgacccgag agctggaggc tgaacggcag atcgtagcca gccagctgga      240

gcgatgcaag ctcggatccg agactggcag catgagcagc atgagttcag cagaagagca      300

gtttcagtgg cagtcacaag atggtcaaaa agatatcgaa gatgagctta caacaggtct      360

cgagctggtg gactcctgta ttaggtcact acaggaatca ggaatacttg acccacagga      420

ttattctaca ggtgaaaggc ccagcctgct ctcccagagt gcacttcagc tcaattccaa      480

acctgaaggg tctttccagt atccggccag ctaccatagc aaccagaccc tggccctggg      540

ggaaaccacc ccttcacagc tcccggcccg aggcacacaa gcccgagcta cgggccagag      600

cttcagccag ggcacgacca gccgcgccgg ccacctggcg gggcccgagc ccgcgccgcc      660

gccgccgccg ccgccgcggg agccgttcgc gcccagcctg ggcagcgcct tccacctgcc      720

cgacgcgccg cccgccgccg ccgccgccgc gctctactac tccagctcca cgctgcccgc      780

gccgccgcgc gggggctccc cgctggccgc gccccagggc ggttcgccca ccaagctgca      840

gcgcggcggc tcggcccccg agggcgccac ctacgccgcg ccgcgcggct cctcgcccaa      900

gcagtcgccc agccgcctgg ccaagtccta cagcaccagc tcgcccatca acatcgtcgt      960

gtcctcggcc ggcctgtccc cgatccgcgt gacctcgccc cccaccgtgc agtccaccat     1020

ctcctcctcg cccatccacc agctgagctc caccatcggc acgtacgcca ccctgtcgcc     1080

caccaagcgc ctggtccacg cgtccgagca gtacagcaag cactcgcagg agctgtatgc     1140

cacggccacc ctccagaggc cgggcagcct ggcagctggt tcccgagcct catacagcag     1200

ccagcatggg cacctgggcc cagagttgcg ggccctgcag tccccagaac accacataga     1260

tcccatctat gaagaccgcg tctatcagaa gccccctatg aggagtctca gccagagcca     1320

gggggaccct ctgccgccag cacacaccgg cacctaccgc acgagcacag ccccatcttc     1380

ccctggtgtc gactccgtcc ccttgcagcg cacaggcagc cagcacggcc cacagaatgc     1440

cgccgcggcc accttccaga gggccagcta tgccgccggc ccagcctcca attacgcgga     1500

cccctaccga cagctgcagt attgtccctc tgttgagtct ccatacagca aatccggccc     1560

tgctctcccg cctgaaggca ccttggccag gtccccgtcc attgatagca ttcagaaaga     1620

tcccagagaa tttggatgga gagacccgga actgccggaa gtgattcaga tgttgcagca     1680

ccagtttccc tcggtccagt ctaacgcggc agcctacttg caacacctct gttttggaga     1740

caacaaaatt aaagccgaga taaggagaca aggaggcatc cagctcctgg tggacctgtt     1800

ggatcatcgg atgaccgaag tccaccgtag tgcctgtgga gctctgagaa acctggtgta     1860

tgggaaggcc aacgatgata acaaaattgc cctgaaaaac tgtggtggca tcccagcact     1920

ggtgaggtta ctccgcaaga cgactgacct ggagatccgg gagctggtca caggagtcct     1980

ttggaacctc tcctcatgcg atgcactcaa aatgccaatc atccaggatg ccctagcagt     2040

actgaccaac gcggtgatta tcccccactc aggctgggaa aattcgcctc ttcaggatga     2100

tcggaaaata cagctgcatt catcacaggt gctgcgtaac gccaccgggt gcctaaggaa     2160

tgttagttcg gccggagagg aggcccgcag aaggatgaga gagtgtgatg ggcttacgga     2220

tgccttgctg tacgtgatcc agtctgcgct ggggagcagt gagatcgata gcaagaccgt     2280

tgaaaactgt gtgtgcattt taaggaacct ctcgtaccgg ctggcggcag aaacgtctca     2340

gggacagcac atgggcacgg acgagctgga cgggctactc tgtggcgagg ccaatggcaa     2400

ggatgctgag agctctgggt gctggggcaa gaagaagaag aaaaagaaat cccaagatca     2460

gtgggatgga gtaggacctc ttccagactg tgctgaacca ccaaaaggga tccagatgct     2520

gtggcaccca tcaatagtca aaccctacct cacactgctc tctgagtgct caaatccaga     2580

cacgctggaa ggggcggcag gcgccctgca gaacttggct gcagggagct ggaagtggtc     2640

agtatatatc cgagccgctg tccgaaaaga gaaaggcctg cccatcctcg tggagctgct     2700

ccgaatagac aatgaccgtg tggtgtgcgc ggtggccact gcgctgcgga acatggcctt     2760

ggacgtcaga aataaggagc tcatcggcaa atacgccatg cgagacctag tccacaggct     2820

tccaggaggg aacaacagca acaacactgc aagcaaggcc atgtcggatg acacagtgac     2880

agctgtctgc tgcacactgc acgaagtgat taccaagaac atggagaacg ccaaggcctt     2940

acgggatgcc ggtggcatcg agaagttggt cggcatctcc aaaagcaaag gagataaaca     3000

ctctccaaaa gtggtcaagg ctgcatctca ggtcctcaac agcatgtggc agtaccgaga     3060

tctgaggagt ctctacaaaa aggatggatg gtcacaatac cactttgtag cctcgtcttc     3120

aaccatcgag agggaccggc aaaggcccta ctcctcctcc cgcacgccct ccatctcccc     3180

tgtgcgcgtg tctcccaaca accgctcagc aagtgcccca gcttcacctc gggaaatgat     3240

cagcctcaaa gaaaggaaaa cagactacga gtgcaccggc agcaacgcca cctaccacgg     3300

agctaaaggc gaacacactt ccaggaaaga tgccatgaca gctcaaaaca ctggaatttc     3360

aactttgtat aggaattctt atggtgcgcc cgctgaagac atcaaacaca accaggtttc     3420

agcacagcca gtcccacagg agcccagcag aaaagattac gagacctacc agccatttca     3480

gaattccaca agaaattacg atgagtcctt cttcgaggac caggtccacc atcgccctcc     3540

cgccagcgag tacaccatgc acctgggtct caagtccacc ggcaactacg ttgacttcta     3600

ctcagctgcc cgtccctaca gtgaactgaa ctatgaaacg agccactacc cggcctcccc     3660

cgactcctgg gtgtgaggag cagggcacag gcgctccggg aacagtgcat gtgcatgcat     3720

accacaagac atttctttct gttttgtttt tttctcctgc aaatttagtt tgttaaagcc     3780

tgttccatag gaaggctgtg ataaccagta aggaaatatt aagagctatt ttagaaagct     3840

aaatgaatcg caagttaact tggaaatcag tagaaagcta aagtgatcct aaatatgaca     3900

gtgggcagca cctttctagc gtgagctgta gagtaacgag aagtgcttta tactgaacgt     3960

ggttgatggg aggagagacg aggcattcgg gccggtgggg cgtaagggtt atcgttaagc     4020

acaagacaca gaatagttta cacactgtgt gggggacggc ttctcacgct ttgtttactc     4080

tcttcatccg ttgtgactct aggcttcagg ttgcattggg gttcctctgt acagcaagat     4140

gtttcttgcc ttttgttaat gcattgttgt aaagtatttg atgtacatta cagattaaag     4200

aagaaaagcg cgttgtgtat attacaccaa tgccgccgtg tttcctcatc tatggttcta     4260

aatattgctt caatttcaaa cttttgaaag atgtatggat ttccagtttt tctttacttt     4320

ctcccagtat gttttaacaa aaaaaaaaaa aagcaggaaa aaaggaatat ttagcagtat     4380

tgttcgttct gatatgtgaa tttgtttgtg acaactaaac aaggcattca gcagtttctg     4440

acaattaaca tacatcattc cacactcctt gtcaacaaag tgctttttca ctgcctaaaa     4500

ttttagatgt agatatttga aatagatttt ttcatttata ccagttttct ttatgatgat     4560

acagtgttaa aagaaaataa attacaattg atctgtcatc catatttgct aagaatgtct     4620

atttccaaga acctatatct tacaaaatac acattcttgc ttgtgtgtct gtgtgtgtgg     4680

gtgtatgtat gtccacgtac tagaaaaatt acctgtgtga gattttattt tgacagaagc     4740

tatttcattt gctgttcatc ttgtacaaac tttgtttttg gttttttagt ataaatgtac     4800

atcagtttgt tccttttgta ctgtatctat tcttctgacc atctagtgac tcaggatatt     4860

aggccagttg aagtggagtt ataggatttt cacacattca cgcatacttg gatatcaacc     4920

ctctctacag gtccgtttcc ttacacattt tatcccctca gaacacgata aaccatggcc     4980

aattcagttt cactttgggg ccaattactt gaagtatcca cagaaaatgt aaactgctcg     5040

ccttattccc ccaaactttt tgttcatgtg gcagggagca gtacacaact atggaataga     5100

ttattaaaac tgaacttgaa gctaacgtta gaatagtggt taacagagct aagaaataag     5160

gctaaccatc gaaaagaaca tgggccgcgg gtaaactagc tttgctcttt agatgcaagt     5220

ggctgaggcc aataggtgcc tagtaaatgt taactgttct tggaaaaaat aaaaacatca     5280

gtaacaaaa                                                             5289


<210>  53
<211>  4551
<212>  DNA
<213>  Homo sapiens

<400>  53
gttcctttta gccgtggtgc agggagggag gagggaggtg ggtaggatgc caggaaccgc       60

ctgctccaca gcctggggaa ggagggaaga gtaacccttc atctttggga ctagtcgtct      120

tgtttgccta gactacagtt ttcaagtatt taaggaccat ttatttcaaa aggaattaca      180

gtttgaaagg ctgacccgag agctggaggc tgaacggcag atcgtagcca gccagctgga      240

gcgatgcaag ctcggatccg agactggcag catgagcagc atgagttcag cagaagagca      300

gtttcagtgg cagtcacaag atggtcaaaa agatatcgaa gatgagctta caacaggtct      360

cgagctggtg gactcctgta ttaggtcact acaggaatca ggaatacttg acccacagga      420

ttattctaca ggtgaaactg gttcccgagc ctcatacagc agccagcatg ggcacctggg      480

cccagagttg cgggccctgc agtccccaga acaccacata gatcccatct atgaagaccg      540

cgtctatcag aagcccccta tgaggagtct cagccagagc cagggggacc ctctgccgcc      600

agcacacacc ggcacctacc gcacgagcac agccccatct tcccctggtg tcgactccgt      660

ccccttgcag cgcacaggca gccagcacgg cccacagaat gccgccgcgg ccaccttcca      720

gagggccagc tatgccgccg gcccagcctc caattacgcg gacccctacc gacagctgca      780

gtattgtccc tctgttgagt ctccatacag caaatccggc cctgctctcc cgcctgaagg      840

caccttggcc aggtccccgt ccattgatag cattcagaaa gatcccagag aatttggatg      900

gagagacccg gaactgccgg aagtgattca gatgttgcag caccagtttc cctcggtcca      960

gtctaacgcg gcagcctact tgcaacacct ctgttttgga gacaacaaaa ttaaagccga     1020

gataaggaga caaggaggca tccagctcct ggtggacctg ttggatcatc ggatgaccga     1080

agtccaccgt agtgcctgtg gagctctgag aaacctggtg tatgggaagg ccaacgatga     1140

taacaaaatt gccctgaaaa actgtggtgg catcccagca ctggtgaggt tactccgcaa     1200

gacgactgac ctggagatcc gggagctggt cacaggagtc ctttggaacc tctcctcatg     1260

cgatgcactc aaaatgccaa tcatccagga tgccctagca gtactgacca acgcggtgat     1320

tatcccccac tcaggctggg aaaattcgcc tcttcaggat gatcggaaaa tacagctgca     1380

ttcatcacag gtgctgcgta acgccaccgg gtgcctaagg aatgttagtt cggccggaga     1440

ggaggcccgc agaaggatga gagagtgtga tgggcttacg gatgccttgc tgtacgtgat     1500

ccagtctgcg ctggggagca gtgagatcga tagcaagacc gttgaaaact gtgtgtgcat     1560

tttaaggaac ctctcgtacc ggctggcggc agaaacgtct cagggacagc acatgggcac     1620

ggacgagctg gacgggctac tctgtggcga ggccaatggc aaggatgctg agagctctgg     1680

gtgctggggc aagaagaaga agaaaaagaa atcccaagat cagtgggatg gagtaggacc     1740

tcttccagac tgtgctgaac caccaaaagg gatccagatg ctgtggcacc catcaatagt     1800

caaaccctac ctcacactgc tctctgagtg ctcaaatcca gacacgctgg aaggggcggc     1860

aggcgccctg cagaacttgg ctgcagggag ctggaagtgg tcagtatata tccgagccgc     1920

tgtccgaaaa gagaaaggcc tgcccatcct cgtggagctg ctccgaatag acaatgaccg     1980

tgtggtgtgc gcggtggcca ctgcgctgcg gaacatggcc ttggacgtca gaaataagga     2040

gctcatcggc aaatacgcca tgcgagacct agtccacagg cttccaggag ggaacaacag     2100

caacaacact gcaagcaagg ccatgtcgga tgacacagtg acagctgtct gctgcacact     2160

gcacgaagtg attaccaaga acatggagaa cgccaaggcc ttacgggatg ccggtggcat     2220

cgagaagttg gtcggcatct ccaaaagcaa aggagataaa cactctccaa aagtggtcaa     2280

ggctgcatct caggtcctca acagcatgtg gcagtaccga gatctgagga gtctctacaa     2340

aaaggatgga tggtcacaat accactttgt agcctcgtct tcaaccatcg agagggaccg     2400

gcaaaggccc tactcctcct cccgcacgcc ctccatctcc cctgtgcgcg tgtctcccaa     2460

caaccgctca gcaagtgccc cagcttcacc tcgggaaatg atcagcctca aagaaaggaa     2520

aacagactac gagtgcaccg gcagcaacgc cacctaccac ggagctaaag gcgaacacac     2580

ttccaggaaa gatgccatga cagctcaaaa cactggaatt tcaactttgt ataggaattc     2640

ttatggtgcg cccgctgaag acatcaaaca caaccaggtt tcagcacagc cagtcccaca     2700

ggagcccagc agaaaagatt acgagaccta ccagccattt cagaattcca caagaaatta     2760

cgatgagtcc ttcttcgagg accaggtcca ccatcgccct cccgccagcg agtacaccat     2820

gcacctgggt ctcaagtcca ccggcaacta cgttgacttc tactcagctg cccgtcccta     2880

cagtgaactg aactatgaaa cgagccacta cccggcctcc cccgactcct gggtgtgagg     2940

agcagggcac aggcgctccg ggaacagtgc atgtgcatgc ataccacaag acatttcttt     3000

ctgttttgtt tttttctcct gcaaatttag tttgttaaag cctgttccat aggaaggctg     3060

tgataaccag taaggaaata ttaagagcta ttttagaaag ctaaatgaat cgcaagttaa     3120

cttggaaatc agtagaaagc taaagtgatc ctaaatatga cagtgggcag cacctttcta     3180

gcgtgagctg tagagtaacg agaagtgctt tatactgaac gtggttgatg ggaggagaga     3240

cgaggcattc gggccggtgg ggcgtaaggg ttatcgttaa gcacaagaca cagaatagtt     3300

tacacactgt gtgggggacg gcttctcacg ctttgtttac tctcttcatc cgttgtgact     3360

ctaggcttca ggttgcattg gggttcctct gtacagcaag atgtttcttg ccttttgtta     3420

atgcattgtt gtaaagtatt tgatgtacat tacagattaa agaagaaaag cgcgttgtgt     3480

atattacacc aatgccgccg tgtttcctca tctatggttc taaatattgc ttcaatttca     3540

aacttttgaa agatgtatgg atttccagtt tttctttact ttctcccagt atgttttaac     3600

aaaaaaaaaa aaaagcagga aaaaaggaat atttagcagt attgttcgtt ctgatatgtg     3660

aatttgtttg tgacaactaa acaaggcatt cagcagtttc tgacaattaa catacatcat     3720

tccacactcc ttgtcaacaa agtgcttttt cactgcctaa aattttagat gtagatattt     3780

gaaatagatt ttttcattta taccagtttt ctttatgatg atacagtgtt aaaagaaaat     3840

aaattacaat tgatctgtca tccatatttg ctaagaatgt ctatttccaa gaacctatat     3900

cttacaaaat acacattctt gcttgtgtgt ctgtgtgtgt gggtgtatgt atgtccacgt     3960

actagaaaaa ttacctgtgt gagattttat tttgacagaa gctatttcat ttgctgttca     4020

tcttgtacaa actttgtttt tggtttttta gtataaatgt acatcagttt gttccttttg     4080

tactgtatct attcttctga ccatctagtg actcaggata ttaggccagt tgaagtggag     4140

ttataggatt ttcacacatt cacgcatact tggatatcaa ccctctctac aggtccgttt     4200

ccttacacat tttatcccct cagaacacga taaaccatgg ccaattcagt ttcactttgg     4260

ggccaattac ttgaagtatc cacagaaaat gtaaactgct cgccttattc ccccaaactt     4320

tttgttcatg tggcagggag cagtacacaa ctatggaata gattattaaa actgaacttg     4380

aagctaacgt tagaatagtg gttaacagag ctaagaaata aggctaacca tcgaaaagaa     4440

catgggccgc gggtaaacta gctttgctct ttagatgcaa gtggctgagg ccaataggtg     4500

cctagtaaat gttaactgtt cttggaaaaa ataaaaacat cagtaacaaa a              4551


<210>  54
<211>  4916
<212>  DNA
<213>  Homo sapiens

<400>  54
gcgtcgggag ccgcctctcg cccgcggcgc tcgcccctgc cgcccgccag catcccttgt       60

cccgcggccg cgctcagaca acaaaagcgg aagatgctgc agttgggcaa ggtcaggacc      120

ttgccctgaa gccgggcggc gccgcgcacg cctcttcccg gactgaggag ctgtcgccgg      180

cggagggtgc atgtttgcga ggaagccgcc gggcgccgcg cctttgggag ctatgcctgt      240

tccagaccag ccttcatcag cctcagagaa gacgagttcc ctgagccccg gcttaaacac      300

ctccaacggg gatggctctg aaacagaaac cacctctgcc atcctcgcct cagtcaaaga      360

acaggaatta cagtttgaaa ggctgacccg agagctggag gctgaacggc agatcgtagc      420

cagccagctg gagcgatgca agctcggatc cgagactggc agcatgagca gcatgagttc      480

agcagaagag cagtttcagt ggcagtcaca agatggtcaa aaagatatcg aagatgagct      540

tacaacaggt ctcgagctgg tggactcctg tattaggtca ctacaggaat caggaatact      600

tgacccacag gattattcta caggtgaaag gcccagcctg ctctcccaga gtgcacttca      660

gctcaattcc aaacctgaag ggtctttcca gtatccggcc agctaccata gcaaccagac      720

cctggccctg ggggaaacca ccccttcaca gctcccggcc cgaggcacac aagcccgagc      780

tacgggccag agcttcagcc agctggttcc cgagcctcat acagcagcca gcatgggcac      840

ctgggcccag agttgcgggc cctgcagtcc ccagaacacc acatagatcc catctatgaa      900

gaccgcgtct atcagaagcc ccctatgagg agtctcagcc agagccaggg ggaccctctg      960

ccgccagcac acaccggcac ctaccgcacg agcacagccc catcttcccc tggtgtcgac     1020

tccgtcccct tgcagcgcac aggcagccag cacggcccac agaatgccgc cgcggccacc     1080

ttccagaggg ccagctatgc cgccggccca gcctccaatt acgcggaccc ctaccgacag     1140

ctgcagtatt gtccctctgt tgagtctcca tacagcaaat ccggccctgc tctcccgcct     1200

gaaggcacct tggccaggtc cccgtccatt gatagcattc agaaagatcc cagagaattt     1260

ggatggagag acccggaact gccggaagtg attcagatgt tgcagcacca gtttccctcg     1320

gtccagtcta acgcggcagc ctacttgcaa cacctctgtt ttggagacaa caaaattaaa     1380

gccgagataa ggagacaagg aggcatccag ctcctggtgg acctgttgga tcatcggatg     1440

accgaagtcc accgtagtgc ctgtggagct ctgagaaacc tggtgtatgg gaaggccaac     1500

gatgataaca aaattgccct gaaaaactgt ggtggcatcc cagcactggt gaggttactc     1560

cgcaagacga ctgacctgga gatccgggag ctggtcacag gagtcctttg gaacctctcc     1620

tcatgcgatg cactcaaaat gccaatcatc caggatgccc tagcagtact gaccaacgcg     1680

gtgattatcc cccactcagg ctgggaaaat tcgcctcttc aggatgatcg gaaaatacag     1740

ctgcattcat cacaggtgct gcgtaacgcc accgggtgcc taaggaatgt tagttcggcc     1800

ggagaggagg cccgcagaag gatgagagag tgtgatgggc ttacggatgc cttgctgtac     1860

gtgatccagt ctgcgctggg gagcagtgag atcgatagca agaccgttga aaactgtgtg     1920

tgcattttaa ggaacctctc gtaccggctg gcggcagaaa cgtctcaggg acagcacatg     1980

ggcacggacg agctggacgg gctactctgt ggcgaggcca atggcaagga tgctgagagc     2040

tctgggtgct ggggcaagaa gaagaagaaa aagaaatccc aagatcagtg ggatggagta     2100

ggacctcttc cagactgtgc tgaaccacca aaagggatcc agatgctgtg gcacccatca     2160

atagtcaaac cctacctcac actgctctct gagtgctcaa atccagacac gctggaaggg     2220

gcggcaggcg ccctgcagaa cttggctgca gggagctgga agtggtcagt atatatccga     2280

gccgctgtcc gaaaagagaa aggcctgccc atcctcgtgg agctgctccg aatagacaat     2340

gaccgtgtgg tgtgcgcggt ggccactgcg ctgcggaaca tggccttgga cgtcagaaat     2400

aaggagctca tcggcaaata cgccatgcga gacctagtcc acaggcttcc aggagggaac     2460

aacagcaaca acactgcaag caaggccatg tcggatgaca cagtgacagc tgtctgctgc     2520

acactgcacg aagtgattac caagaacatg gagaacgcca aggccttacg ggatgccggt     2580

ggcatcgaga agttggtcgg catctccaaa agcaaaggag ataaacactc tccaaaagtg     2640

gtcaaggctg catctcaggt cctcaacagc atgtggcagt accgagatct gaggagtctc     2700

tacaaaaagg atggatggtc acaataccac tttgtagcct cgtcttcaac catcgagagg     2760

gaccggcaaa ggccctactc ctcctcccgc acgccctcca tctcccctgt gcgcgtgtct     2820

cccaacaacc gctcagcaag tgccccagct tcacctcggg aaatgatcag cctcaaagaa     2880

aggaaaacag actacgagtg caccggcagc aacgccacct accacggagc taaaggcgaa     2940

cacacttcca ggaaagatgc catgacagct caaaacactg gaatttcaac tttgtatagg     3000

aattcttatg gtgcgcccgc tgaagacatc aaacacaacc aggtttcagc acagccagtc     3060

ccacaggagc ccagcagaaa agattacgag acctaccagc catttcagaa ttccacaaga     3120

aattacgatg agtccttctt cgaggaccag gtccaccatc gccctcccgc cagcgagtac     3180

accatgcacc tgggtctcaa gtccaccggc aactacgttg acttctactc agctgcccgt     3240

ccctacagtg aactgaacta tgaaacgagc cactacccgg cctcccccga ctcctgggtg     3300

tgaggagcag ggcacaggcg ctccgggaac agtgcatgtg catgcatacc acaagacatt     3360

tctttctgtt ttgttttttt ctcctgcaaa tttagtttgt taaagcctgt tccataggaa     3420

ggctgtgata accagtaagg aaatattaag agctatttta gaaagctaaa tgaatcgcaa     3480

gttaacttgg aaatcagtag aaagctaaag tgatcctaaa tatgacagtg ggcagcacct     3540

ttctagcgtg agctgtagag taacgagaag tgctttatac tgaacgtggt tgatgggagg     3600

agagacgagg cattcgggcc ggtggggcgt aagggttatc gttaagcaca agacacagaa     3660

tagtttacac actgtgtggg ggacggcttc tcacgctttg tttactctct tcatccgttg     3720

tgactctagg cttcaggttg cattggggtt cctctgtaca gcaagatgtt tcttgccttt     3780

tgttaatgca ttgttgtaaa gtatttgatg tacattacag attaaagaag aaaagcgcgt     3840

tgtgtatatt acaccaatgc cgccgtgttt cctcatctat ggttctaaat attgcttcaa     3900

tttcaaactt ttgaaagatg tatggatttc cagtttttct ttactttctc ccagtatgtt     3960

ttaacaaaaa aaaaaaaaag caggaaaaaa ggaatattta gcagtattgt tcgttctgat     4020

atgtgaattt gtttgtgaca actaaacaag gcattcagca gtttctgaca attaacatac     4080

atcattccac actccttgtc aacaaagtgc tttttcactg cctaaaattt tagatgtaga     4140

tatttgaaat agattttttc atttatacca gttttcttta tgatgataca gtgttaaaag     4200

aaaataaatt acaattgatc tgtcatccat atttgctaag aatgtctatt tccaagaacc     4260

tatatcttac aaaatacaca ttcttgcttg tgtgtctgtg tgtgtgggtg tatgtatgtc     4320

cacgtactag aaaaattacc tgtgtgagat tttattttga cagaagctat ttcatttgct     4380

gttcatcttg tacaaacttt gtttttggtt ttttagtata aatgtacatc agtttgttcc     4440

ttttgtactg tatctattct tctgaccatc tagtgactca ggatattagg ccagttgaag     4500

tggagttata ggattttcac acattcacgc atacttggat atcaaccctc tctacaggtc     4560

cgtttcctta cacattttat cccctcagaa cacgataaac catggccaat tcagtttcac     4620

tttggggcca attacttgaa gtatccacag aaaatgtaaa ctgctcgcct tattccccca     4680

aactttttgt tcatgtggca gggagcagta cacaactatg gaatagatta ttaaaactga     4740

acttgaagct aacgttagaa tagtggttaa cagagctaag aaataaggct aaccatcgaa     4800

aagaacatgg gccgcgggta aactagcttt gctctttaga tgcaagtggc tgaggccaat     4860

aggtgcctag taaatgttaa ctgttcttgg aaaaaataaa aacatcagta acaaaa         4916


<210>  55
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Asp Val Phe Ser Phe Val Lys Ile Ala Lys Leu Ser Ser His Arg 
1               5                   10                  15      


Thr Lys Ser Ser Gly Trp Pro Pro Pro Ser Gly Thr Trp Gly Leu Ser 
            20                  25                  30          


Gln Val Pro Pro Tyr Gly Trp Glu Met Thr Ala Asn Arg Asp Gly Arg 
        35                  40                  45              


Asp Tyr Phe Ile Asn His Met Thr Gln Ala Ile Pro Phe Asp Asp Pro 
    50                  55                  60                  


Arg Leu Glu Ser Cys Gln Ile Ile Pro Pro Ala Pro Arg Lys Val Glu 
65                  70                  75                  80  


Met Arg Arg Asp Pro Val Leu Gly Phe Gly Phe Val Ala Gly Ser Glu 
                85                  90                  95      


Lys Pro Val Val Val Arg Ser Val Thr Pro Gly Gly Pro Ser Glu Gly 
            100                 105                 110         


Lys Leu Ile Pro Gly Asp Gln Ile Val Met Ile Asn Asp Glu Pro Val 
        115                 120                 125             


Ser Ala Ala Pro Arg Glu Arg Val Ile Asp Leu Val Arg Ser Cys Lys 
    130                 135                 140                 


Glu Ser Ile Leu Leu Thr Val Ile Gln Pro Tyr Pro Ser Pro Lys Ser 
145                 150                 155                 160 


Ala Phe Ile Ser Ala Ala Lys Lys Ala Arg Leu Lys Ser Asn Pro Val 
                165                 170                 175     


Lys Val Arg Phe Ser Glu Glu Val Ile Ile Asn Gly Gln Val Ser Glu 
            180                 185                 190         


Thr Val Lys Asp Asn Ser Leu Leu Phe Met Pro Asn Val Leu Lys Val 
        195                 200                 205             


Tyr Leu Glu Asn Gly Gln Thr Lys Ser Phe Arg Phe Asp Cys Ser Thr 
    210                 215                 220                 


Ser Ile Lys Asp Val Ile Leu Thr Leu Gln Glu Lys Leu Ser Ile Lys 
225                 230                 235                 240 


Gly Ile Glu His Phe Ser Leu Met Leu Glu Gln Arg Thr Glu Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Leu Leu Leu His Glu Gln Glu Thr Leu Thr Gln Val 
            260                 265                 270         


Thr Gln Arg Pro Ser Ser His Lys Met Arg Cys Leu Phe Arg Ile Ser 
        275                 280                 285             


Phe Val Pro Lys Asp Pro Ile Asp Leu Leu Arg Arg Asp Pro Val Ala 
    290                 295                 300                 


Phe Glu Tyr Leu Tyr Val Gln Ser Cys Asn Asp Val Val Gln Glu Arg 
305                 310                 315                 320 


Phe Gly Pro Glu Leu Lys Tyr Asp Ile Ala Leu Arg Leu Ala Ala Leu 
                325                 330                 335     


Gln Met Tyr Ile Ala Thr Val Thr Thr Lys Gln Thr Gln Lys Ile Ser 
            340                 345                 350         


Leu Lys Tyr Ile Glu Lys Glu Trp Gly Leu Glu Thr Phe Leu Pro Ser 
        355                 360                 365             


Ala Val Leu Gln Ser Met Lys Glu Lys Asn Ile Lys Lys Ala Leu Ser 
    370                 375                 380                 


His Leu Val Lys Ala Asn Gln Asn Leu Val Pro Pro Gly Lys Lys Leu 
385                 390                 395                 400 


Ser Ala Leu Gln Ala Lys Val His Tyr Leu Lys Phe Leu Ser Asp Leu 
                405                 410                 415     


Arg Leu Tyr Gly Gly Arg Val Phe Lys Ala Thr Leu Val Gln Ala Glu 
            420                 425                 430         


Lys Arg Ser Glu Val Thr Leu Leu Val Gly Pro Arg Tyr Gly Ile Ser 
        435                 440                 445             


His Val Ile Asn Thr Lys Thr Asn Leu Val Ala Leu Leu Ala Asp Phe 
    450                 455                 460                 


Ser His Val Asn Arg Ile Glu Met Phe Ser Glu Glu Glu Ser Leu Val 
465                 470                 475                 480 


Arg Val Glu Leu His Val Leu Asp Val Lys Pro Ile Thr Leu Leu Met 
                485                 490                 495     


Glu Ser Ser Asp Ala Met Asn Leu Ala Cys Leu Thr Ala Gly Tyr Tyr 
            500                 505                 510         


Arg Leu Leu Val Asp Ser Arg Arg Ser Ile Phe Asn Met Ala Asn Lys 
        515                 520                 525             


Lys Asn Thr Ala Thr Gln Glu Thr Gly Pro Glu Asn Lys Gly Lys His 
    530                 535                 540                 


Asn Leu Leu Gly Pro Asp Trp Asn Cys Ile Pro Gln Met Thr Thr Phe 
545                 550                 555                 560 


Ile Gly Glu Gly Glu Gln Glu Ala Gln Ile Thr Tyr Ile Asp Ser Lys 
                565                 570                 575     


Gln Lys Thr Val Glu Ile Thr Asp Ser Thr Met Cys Pro Lys Glu His 
            580                 585                 590         


Arg His Leu Tyr Ile Asp Asn Ala Tyr Ser Ser Asp Gly Leu Asn Gln 
        595                 600                 605             


Gln Leu Ser Gln Pro Gly Glu Ala Pro Cys Glu Ala Asp Tyr Arg Ser 
    610                 615                 620                 


Leu Ala Gln Arg Ser Leu Leu Thr Leu Ser Gly Pro Glu Thr Leu Lys 
625                 630                 635                 640 


Lys Ala Gln Glu Ser Pro Arg Gly Ala Lys Val Ser Phe Ile Phe Gly 
                645                 650                 655     


Asp Phe Ala Leu Asp Asp Gly Ile Ser Pro Pro Thr Leu Gly Tyr Glu 
            660                 665                 670         


Thr Leu Leu Asp Glu Gly Pro Glu Met Leu Glu Lys Gln Arg Asn Leu 
        675                 680                 685             


Tyr Ile Gly Ser Ala Asn Asp Met Lys Gly Leu Asp Leu Thr Pro Glu 
    690                 695                 700                 


Ala Glu Gly Ile Gln Phe Val Glu Asn Ser Val Tyr Ala Asn Ile Gly 
705                 710                 715                 720 


Asp Val Lys Ser Phe Gln Ala Ala Glu Gly Ile Glu Glu Pro Leu Leu 
                725                 730                 735     


His Asp Ile Cys Tyr Ala Glu Asn Thr Asp Asp Ala Glu Asp Glu Asp 
            740                 745                 750         


Glu Val Ser Cys Glu Glu Asp Leu Val Val Gly Glu Met Asn Gln Pro 
        755                 760                 765             


Ala Ile Leu Asn Leu Ser Gly Ser Ser Asp Asp Ile Ile Asp Leu Thr 
    770                 775                 780                 


Ser Leu Pro Pro Pro Glu Gly Asp Asp Asn Glu Asp Asp Phe Leu Leu 
785                 790                 795                 800 


Arg Ser Leu Asn Met Ala Ile Ala Ala Pro Pro Pro Gly Phe Arg Asp 
                805                 810                 815     


Ser Ser Asp Glu Glu Asp Ser Gln Ser Gln Ala Ala Ser Phe Pro Glu 
            820                 825                 830         


Asp Lys Glu Lys Gly Ser Ser Leu Gln Asn Asp Glu Ile Pro Val Ser 
        835                 840                 845             


Leu Ile Asp Ala Val Pro Thr Ser Ala Glu Gly Lys Cys Glu Lys Gly 
    850                 855                 860                 


Leu Asp Asn Ala Val Val Ser Thr Leu Gly Ala Leu Glu Ala Leu Ser 
865                 870                 875                 880 


Val Ser Glu Glu Gln Gln Thr Ser Asp Asn Ser Gly Val Ala Ile Leu 
                885                 890                 895     


Arg Ala Tyr Ser Pro Glu Ser Ser Ser Asp Ser Gly Asn Glu Thr Asn 
            900                 905                 910         


Ser Ser Glu Met Thr Glu Ser Ser Glu Leu Ala Thr Ala Gln Lys Gln 
        915                 920                 925             


Ser Glu Asn Leu Ser Arg Met Phe Leu Ala Thr His Glu Gly Tyr His 
    930                 935                 940                 


Pro Leu Ala Glu Glu Gln Thr Glu Phe Pro Ala Ser Lys Thr Pro Ala 
945                 950                 955                 960 


Gly Gly Leu Pro Pro Lys Ser Ser His Ala Leu Ala Ala Arg Pro Ala 
                965                 970                 975     


Thr Asp Leu Pro Pro Lys Val Val Pro Ser Lys Gln Leu Leu His Ser 
            980                 985                 990         


Asp His Met Glu Met Glu Pro Glu  Thr Met Glu Thr Lys  Ser Val Thr 
        995                 1000                 1005             


Asp Tyr  Phe Ser Lys Leu His  Met Gly Ser Val Ala  Tyr Ser Cys 
    1010                 1015                 1020             


Thr Ser  Lys Arg Lys Ser Lys  Leu Ala Asp Gly Glu  Gly Lys Ala 
    1025                 1030                 1035             


Pro Pro  Asn Gly Asn Thr Thr  Gly Lys Lys Gln Gln  Gly Thr Lys 
    1040                 1045                 1050             


Thr Ala  Glu Met Glu Glu Glu  Ala Ser Gly Lys Phe  Gly Thr Val 
    1055                 1060                 1065             


Ser Ser  Arg Asp Ser Gln His  Leu Ser Thr Phe Asn  Leu Glu Arg 
    1070                 1075                 1080             


Thr Ala  Phe Arg Lys Asp Ser  Gln Arg Trp Tyr Val  Ala Thr Glu 
    1085                 1090                 1095             


Gly Gly  Met Ala Glu Lys Ser  Gly Leu Glu Ala Ala  Thr Gly Lys 
    1100                 1105                 1110             


Thr Phe  Pro Arg Ala Ser Gly  Leu Gly Ala Arg Glu  Ala Glu Gly 
    1115                 1120                 1125             


Lys Glu  Glu Gly Ala Pro Asp  Gly Glu Thr Ser Asp  Gly Ser Gly 
    1130                 1135                 1140             


Leu Gly  Gln Gly Asp Arg Phe  Leu Thr Asp Val Thr  Cys Ala Ser 
    1145                 1150                 1155             


Ser Ala  Lys Asp Leu Asp Asn  Pro Glu Asp Ala Asp  Ser Ser Thr 
    1160                 1165                 1170             


Cys Asp  His Pro Ser Lys Leu  Pro Glu Ala Asp Glu  Ser Val Ala 
    1175                 1180                 1185             


Arg Leu  Cys Asp Tyr His Leu  Ala Lys Arg Met Ser  Ser Leu Gln 
    1190                 1195                 1200             


Ser Glu  Gly His Phe Ser Leu  Gln Ser Ser Gln Gly  Ser Ser Val 
    1205                 1210                 1215             


Asp Ala  Gly Cys Gly Thr Gly  Ser Ser Gly Ser Ala  Cys Ala Thr 
    1220                 1225                 1230             


Pro Val  Glu Ser Pro Leu Cys  Pro Ser Leu Gly Lys  His Leu Ile 
    1235                 1240                 1245             


Pro Asp  Ala Ser Gly Lys Gly  Val Asn Tyr Ile Pro  Ser Glu Glu 
    1250                 1255                 1260             


Arg Ala  Pro Gly Leu Pro Asn  His Gly Ala Thr Phe  Lys Glu Leu 
    1265                 1270                 1275             


His Pro  Gln Thr Glu Gly Met  Cys Pro Arg Met Thr  Val Pro Ala 
    1280                 1285                 1290             


Leu His  Thr Ala Ile Asn Thr  Glu Pro Leu Phe Gly  Thr Leu Arg 
    1295                 1300                 1305             


Asp Gly  Cys His Arg Leu Pro  Lys Ile Lys Glu Thr  Thr Val 
    1310                 1315                 1320         


<210>  56
<211>  8477
<212>  DNA
<213>  Homo sapiens

<400>  56
gggaggcagc tgcagtgctg cgaggggtgc gtgcgcgtgt gcccagctcg cctgccgtct       60

cccggctccg tctgcgctcc tcggtgcgtg gggcacgagg gtccgagggc cgggaagcca      120

gagcagcgcc tctcgcccag gcctcgcttt ctctggacgc ccggcagtcc ccggggctag      180

agcgcacggg gcggggcgcg agacccgggc cgcgctcccc gcccccgcct cttgcgccct      240

gcctggctcc ctctccattg agttttcctg cctcgggtgc ctatcaatgg tcctgctcgg      300

ggatgcacac gcagctcgcg gccggagggg ggtagcagcc gccgcctcca ggtgcaggtt      360

ctctccggcc gccgccgcca cccgctgtcg ccgcgactcg agccccgggc gcactgaggt      420

cttggccatg gggctgcgga ggctgctgtt gctggcgtga gaaggggcga cggagttgtc      480

gcgctcgggg gtccccagct gcctgcatgg atgtcttcag ctttgtgaag attgcaaagc      540

tttcgagcca caggacgaag tcttcaggct ggccgcctcc ctcgggaacc tggggcttga      600

gccaggtgcc gccctatgga tgggagatga cggcaaaccg agatgggcga gactacttca      660

tcaatcacat gacacaggca atcccttttg acgaccctcg gttagagagc tgccaaatca      720

tccctccggc tcctcggaag gtggagatga gaagggaccc cgtgctggga tttggttttg      780

tggcaggcag tgaaaagcca gtggtcgttc gctcagtaac accaggtggc ccctctgaag      840

gcaagctgat cccgggagat cagattgtaa tgattaatga tgaaccggtc agcgctgcac      900

ccagagagcg ggtcatcgat ctggtcagaa gctgcaaaga atcgatactc ctcactgtca      960

ttcagcctta cccttctccc aaatcagcat ttattagtgc tgcaaaaaag gcaagattaa     1020

agtccaatcc tgtcaaagta cgcttctctg aggaggtcat catcaacggc caagtgtcgg     1080

aaactgttaa ggacaactca cttcttttta tgccaaatgt tttgaaagtc tatctggaaa     1140

atgggcagac caaatcattt cgttttgact gcagcacttc cattaaggat gtcatcttaa     1200

cccttcaaga gaagctctcc atcaaaggca ttgaacactt ctctctcatg ctggagcaga     1260

ggacagaagg ggctggaacg aagctgctct tgcttcatga acaggagact ctaactcagg     1320

tgacacagag gcccagctcc cataagatga gatgtctttt ccgaattagc ttcgtcccaa     1380

aagatccaat tgacctttta aggagagatc cagttgcttt cgagtatctc tatgttcaga     1440

gttgtaacga tgtggttcag gagcgatttg ggccggagct gaaatatgac atagccctgc     1500

ggctggccgc attacaaatg tacattgcaa ccgttaccac caagcaaacg cagaaaatct     1560

ccctcaaata catcgaaaaa gaatggggat tagagacttt tcttccctct gctgtgctgc     1620

aaagcatgaa agagaagaac ataaagaaag cactttcaca ccttgtcaaa gcaaatcaaa     1680

acttggtacc accgggtaaa aagctctctg cactacaagc caaggtccat tatctcaagt     1740

tcctcagtga cctacgattg tatgggggcc gtgtgttcaa ggcaacatta gtgcaggcag     1800

aaaagcgctc ggaagtgact ctcctggttg ggccccggta tggcataagc catgtcatca     1860

acaccaaaac caatctggtg gctcttttag ccgactttag ccacgtcaac aggatcgaaa     1920

tgttttccga ggaggagagc ttggtgcggg tagaactcca cgtgctagat gtgaagccta     1980

tcacgcttct gatggaatcc tcagatgcca tgaacctggc ctgcttgacg gctggatact     2040

accggctgct tgttgattcc aggaggtcga tatttaacat ggccaacaag aaaaacacag     2100

cgacccagga aacaggacct gaaaacaagg ggaagcataa cctccttggc ccagattgga     2160

actgtatacc ccaaatgacc acctttattg gcgaagggga acaagaagcc cagataacat     2220

acatagattc aaagcagaag acggtggaga tcacagacag caccatgtgt ccaaaagagc     2280

accggcactt gtacatagac aatgcctata gttcagatgg acttaaccag cagctgagcc     2340

agcccgggga ggccccctgt gaggcagact acagaagtct agctcagcgg tccctattga     2400

ccctctcagg accagaaact ctgaagaaag cacaggaatc tccgagagga gctaaagtgt     2460

cctttatttt tggagacttc gccttggatg atggtattag tcccccaacc cttggctatg     2520

aaacgctact agatgagggt cctgaaatgc tggagaagca gagaaatctc tacattggca     2580

gtgccaatga catgaagggc ctggatctca ctccagaggc agagggcatc cagtttgtgg     2640

aaaattctgt ttatgcaaac ataggcgatg tgaagagctt ccaggccgcg gaggggatcg     2700

aggaacccct cttgcatgac atctgttatg cagaaaacac tgatgacgcg gaggacgagg     2760

acgaggtgag ctgcgaggag gacctcgtgg tgggggagat gaaccagccg gccatcctca     2820

acctgtctgg gtcaagcgat gacatcattg acctcacatc cctgccccct ccagaaggtg     2880

atgacaatga ggatgacttc ctgttgcgtt ccttgaacat ggccattgcc gcacccccac     2940

ctggctttag agacagttca gatgaagagg actctcagag ccaggcagct tccttccccg     3000

aggacaagga gaaaggcagc agcctgcaaa atgatgagat ccccgtgtcc ctcattgacg     3060

ctgtgcccac cagcgccgaa ggcaagtgtg agaagggact ggataatgcc gtcgtctcca     3120

cgctgggagc tctagaggct ctatccgtgt cagaagaaca gcagaccagt gacaattcag     3180

gtgtagccat cttgcgggct tatagtcctg agtcttcgtc agactcgggc aatgaaacta     3240

actcttctga aatgactgag agttctgaac tggccacagc acaaaaacag tcagaaaacc     3300

tctcccgcat gttcttggcc actcacgaag gctaccaccc ccttgcagaa gagcagaccg     3360

agttcccggc ctccaagacc cccgctgggg gcttgcctcc aaagtcctcg cacgccctgg     3420

ctgctaggcc agcaaccgac ctcccgccca aagttgtgcc ttccaagcag ttacttcact     3480

cagaccacat ggagatggag cctgaaacta tggagactaa gtcggtcact gactatttta     3540

gcaaactgca catggggtcg gtggcatact cctgcactag caaaaggaaa agcaagctgg     3600

ccgatggtga ggggaaggca ccccctaatg ggaacacaac aggaaaaaaa cagcagggga     3660

ccaaaacggc agagatggag gaggaggcca gtggtaaatt tggtactgtg tcttcacgag     3720

acagtcaaca cctgagcact tttaatctgg agagaactgc ctttcgcaag gacagtcaaa     3780

gatggtatgt ggccactgaa ggtgggatgg ctgaaaaaag tggattagaa gcagcaacag     3840

ggaaaacctt tccaagagct tctggtcttg gggcaaggga ggccgaaggg aaggaagaag     3900

gagctcctga tggagaaacc agtgatggct caggacttgg tcaaggggac cgcttcttaa     3960

ctgacgtgac ctgtgcatct tcagccaaag acttagataa cccagaggac gctgactcgt     4020

ccacctgcga ccatccttcc aagcttcctg aggctgatga gagtgtggcc cgcctttgtg     4080

actaccactt ggccaagcgg atgtcatcac tgcaaagcga gggccatttt tctctgcaga     4140

gctcccaagg ctcttcagtg gatgcaggct gtggcacagg cagcagtggc agtgcctgtg     4200

ccacacccgt ggagtcgccg ctctgcccct ccctggggaa gcacttgatt cctgacgctt     4260

ctgggaaagg cgtgaattac attccttcag aggagagagc ccctgggctt cccaaccacg     4320

gagccacctt taaggaactg cacccacaga cagaagggat gtgtccacgg atgacagtgc     4380

ctgctctgca cacagccatt aacaccgaac ccctgtttgg cacattgaga gatggatgcc     4440

atcggctccc caagattaag gaaaccacag tgtagctttg acagagcctg ggaaggagag     4500

acgaggaggc atgccttcag cttggtctca acatcctgaa gctgatccca tcctgctacc     4560

atcaaacatt cactcggaat caaaggtgcc aattccaaat caagacccta atgatttctc     4620

ccaagcaaat caggcatacg gagaggctgt gagctggcgg ccaccggatc tgagaggggg     4680

gagcctcagg acacctccca gccagaaggc tctgagacat agcagcagta tcctctccgg     4740

atctgtcgat ttggagacct tccgagagag aaccaagggt gcagtcagct taaagtgtcc     4800

aggcatcaca gaagcacagg aggccagttc tgaaaggcga gcagaactcc ccctggggag     4860

gaagctcacc aaaagttttt cccaaagctc aatgcacttg agctctgagg ggaggtttca     4920

caaaaggtcc ccagtggctc ataaagactc aaagctgtat aggacattac ccttgcggaa     4980

gctggagggc agcaattgga gatgccgggg acccttcagc tattgcttcc tgaaccgagg     5040

gcaggatgaa gatggtgagg aagaagagga gaggggagag gccaccgtcc aggtctcttg     5100

cctctataga ccacagatga ctcaagccat gccagaacca agcagcccat gcctggctgt     5160

ggcgattcag aagcaacgag gggagctatc cagagggtca gtgctgaagg tctgggcaga     5220

agacctgcga gacccagatg acttggactt cagcaacctg gcttttgatg cccggattgc     5280

aagaataaat gccctaaagg agagcacata tgcaatgcct gatgggttcc ttgcagccca     5340

aaatgatgcc aatgagctgc tctgtctcgt cagggcaacc aaggagaaga gggaggagtc     5400

acgccctgaa gcgtacgacc ttacactttc tcagtacaag caactgttat ccattgagtc     5460

cagacagttg ggaagtgcct gtaggaaaat ggcgatggct gagaaaagcc cggaggagat     5520

gctcctagct atgacttcca gctttcaagt gctctgttgc ctaacagaag cttgcatgcg     5580

attagttaaa gtcgtgaact cagaaacaca gcggcaggaa attgtaggga agatcgatga     5640

agtggtcata aattacattt gtctactgaa agctgccgaa gcagccactg gaaagaaccc     5700

tggggaccct aatgttggac tctcggcgcg acactcaacc accatggccg ctctcgtaag     5760

cacactgaca cgttctctca agaggctttt aaacaaataa atatggaagt cacgtcataa     5820

tctacctttg caaagccata catgaacttt tatttacttt gtgtgtatga tgaacagatg     5880

tctcctttct tctctctgta tattttgtta ttttatataa aataggagat aaaagtcaca     5940

ttgatgaaat gttgaaatgt actaatcaga tgtattctgt ttatattata catatatata     6000

cacgtaaaag aaatatccaa gaaagtgatg acatttggct atttttcata tagttaaaac     6060

tccaggtata tgatgtgaaa ttttaaattc taccatgtta gagcaaaaca atgaatccta     6120

tcccctttct ttccaagtag ctacttggaa accatatcat tcatatttag aagtaaaaca     6180

caaaacaaaa aagagagaga aaagaaaaga aatcacaatg tatataaaac agtacttatg     6240

ttttaaaatt atgattttta agcattggaa atagcaaaaa gacatttaaa attcaagaag     6300

ctattatgaa ttactagaga atatatctgt aataaattaa ttttttgctc atagtatttg     6360

gttactggat gctttcttcc aagaatccca catatttaat ttgggttttt gctactgggg     6420

ctacaaattg gtggggatgg attctactgt gtcagcacaa atgctcttca cagtggttct     6480

agcatttaaa aaacttcccg gggagaagaa cagaggggat gatgggcagt ttcctaggta     6540

acacctagag ttatagaata tctcattaca taaaatgtat ggaattaata ataccaaaat     6600

taattatttg atggaaagat ctgctttgac taaatgtcaa aaatctgcaa accaaagaca     6660

ttatcttccc ctcatcccaa ctcaactacg aaacttaaaa ttccctttag agtgatagga     6720

catttagtaa agtatttgca aacttaaaaa aaggaacatt taatgatcat caaaattaag     6780

tacagattca gtaatgtaga ccagaccaca caccagcacc tgtgagtctc atctcagatc     6840

acagctctca gcatagggct tcatgcatca ccgcctctac agaggctaag gctgccagtc     6900

aaatttggaa ttatagcgta gtactgggac aaaatctcaa atcttggatg ttccagaaaa     6960

tcagggagag atggctactg taatcatggg agccatgagt aaatagttaa gtatttatta     7020

aataaatact taatctggat tggctgataa aaatatgaaa tctgaaaaaa aaaagaaaga     7080

aatggaagtg gtatatttga ccagttcaag tgaaaccaat ggaatgcaaa gaactttcca     7140

ggactgtcac atctctaaaa gtaccctgca gtcataaaat aaaatcgata tgtatatatg     7200

tatttcctgg gtcattcagt gctcaagtta catgcactcc tacttagaca ggtggctcct     7260

taagaacatg atgggagtac accaggtgca aatatttcta cttttgtagc ctgctgagaa     7320

ggagtcataa cacagtccac aattgcaatc tctctctagt cagccattcc acagggactc     7380

aacaacaaaa gccgcacgtg gttatggatg gcagcaaagg aaaggagttt aggtgtgtgt     7440

tattataaat aatgtttaac taaataataa aacattattt cattacaatt ataattataa     7500

atattggtgt tttgatattg agagatatta gtggtgttta ctgtggaaaa tcttagtaaa     7560

tatcattctg tgtactaaaa tcctaaccta ttaataggat gtgtgcccta tgtcagacag     7620

tgtgctaagc atattaacta tattatctca tttaatcatc acaacaatct gctggtttgg     7680

acactattct ctctggaggc aatatggatg agttcttacg gatatggggt ttggggtcag     7740

aaacatcttg attaaaattt tgactctgcc attttctagc ccttttatgt tgggaaagct     7800

actttttcta gtctcaattt cctcataata aaatgaaaat caattataag atcgatttcc     7860

atagggttgt catgagtttt gagtaaaaat gtgtatgtaa agttcttacc acaatacctg     7920

gcagagagta agtattcaat taatgttagc tattattatc atcataatcg ttgtgttaaa     7980

tatattgccc aagataatat gtgggggaat gtttgtttta tatgcatatt gtatcctgac     8040

tgtgtgcaga acacattatg tgtattgcat atatgtaaaa gaagtgtaca aggaagtggc     8100

catccttgtt caagttacgt atctagttag aacaacttcc cagtccattg gagttctttg     8160

agaagcctca gggaagtagc tctgggtcct tctaatcaac ctcccattac tgcgccagta     8220

agtttctgtt tcttataaat aaactctttg ctattcagaa aacctcaagg ggcccccaca     8280

ttcactaagc atggggctcc taactggggt ccaggtccat agagtgtagg aagaacatat     8340

tagaacaata cttgtgctta tttttatcta gcttttttat gtttgtgtat gttttataat     8400

ggcataatag tacaatggta catgtacata attttaaata aataaatgaa tgaatgaata     8460

aataaaaaaa aaaaaaa                                                    8477


<210>  57
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Arg Ala Glu Glu Pro Cys Ala Pro Gly Ala Pro Ser Ala Leu Gly 
1               5                   10                  15      


Ala Gln Arg Thr Pro Gly Pro Glu Leu Arg Leu Ser Ser Gln Leu Leu 
            20                  25                  30          


Pro Glu Leu Cys Thr Phe Val Val Arg Val Leu Phe Tyr Leu Gly Pro 
        35                  40                  45              


Val Tyr Leu Ala Gly Tyr Leu Gly Leu Ser Ile Thr Trp Leu Leu Leu 
    50                  55                  60                  


Gly Ala Leu Leu Trp Met Trp Trp Arg Arg Asn Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Gly Arg Leu Ala Ala Ala Phe Glu Phe Leu Asp Asn Glu Arg Glu Phe 
                85                  90                  95      


Ile Ser Arg Glu Leu Arg Gly Gln His Leu Pro Ala Trp Ile His Phe 
            100                 105                 110         


Pro Asp Val Glu Arg Val Glu Trp Ala Asn Lys Ile Ile Ser Gln Thr 
        115                 120                 125             


Trp Pro Tyr Leu Ser Met Ile Met Glu Ser Lys Phe Arg Glu Lys Leu 
    130                 135                 140                 


Glu Pro Lys Ile Arg Glu Lys Ser Ile His Leu Arg Thr Phe Thr Phe 
145                 150                 155                 160 


Thr Lys Leu Tyr Phe Gly Gln Lys Cys Pro Arg Val Asn Gly Val Lys 
                165                 170                 175     


Ala His Thr Asn Thr Cys Asn Arg Arg Arg Val Thr Val Asp Leu Gln 
            180                 185                 190         


Ile Cys Tyr Ile Gly Asp Cys Glu Ile Ser Val Glu Leu Gln Lys Ile 
        195                 200                 205             


Gln Ala Gly Val Asn Gly Ile Gln Leu Gln Gly Thr Leu Arg Val Ile 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Asp Lys Pro Phe Val Gly Ala Val Thr Val 
225                 230                 235                 240 


Phe Phe Leu Gln Lys Pro His Leu Gln Ile Asn Trp Thr Gly Leu Thr 
                245                 250                 255     


Asn Leu Leu Asp Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu Leu 
            260                 265                 270         


Glu Asp Leu Ile Ala Thr His Leu Val Leu Pro Asn Arg Val Thr Val 
        275                 280                 285             


Pro Val Lys Lys Gly Leu Asp Leu Thr Asn Leu Arg Phe Pro Leu Pro 
    290                 295                 300                 


Cys Gly Val Ile Arg Val His Leu Leu Glu Ala Glu Gln Leu Ala Gln 
305                 310                 315                 320 


Lys Asp Asn Phe Leu Gly Leu Arg Gly Lys Ser Asp Pro Tyr Ala Lys 
                325                 330                 335     


Val Ser Ile Gly Leu Gln His Phe Arg Ser Arg Thr Ile Tyr Arg Asn 
            340                 345                 350         


Leu Asn Pro Thr Trp Asn Glu Val Phe Glu Phe Met Val Tyr Glu Val 
        355                 360                 365             


Pro Gly Gln Asp Leu Glu Val Asp Leu Tyr Asp Glu Asp Thr Asp Arg 
    370                 375                 380                 


Asp Asp Phe Leu Gly Ser Leu Gln Ile Cys Leu Gly Asp Val Met Thr 
385                 390                 395                 400 


Asn Arg Val Val Asp Glu Trp Phe Val Leu Asn Asp Thr Thr Ser Gly 
                405                 410                 415     


Arg Leu His Leu Arg Leu Glu Trp Leu Ser Leu Leu Thr Asp Gln Glu 
            420                 425                 430         


Val Leu Thr Glu Asp His Gly Gly Leu Ser Thr Ala Ile Leu Val Val 
        435                 440                 445             


Phe Leu Glu Ser Ala Cys Asn Leu Pro Arg Asn Pro Phe Asp Tyr Leu 
    450                 455                 460                 


Asn Gly Glu Tyr Arg Ala Lys Lys Leu Ser Arg Phe Ala Arg Asn Lys 
465                 470                 475                 480 


Val Ser Lys Asp Pro Ser Ser Tyr Val Lys Leu Ser Val Gly Lys Lys 
                485                 490                 495     


Thr His Thr Ser Lys Thr Cys Pro His Asn Lys Asp Pro Val Trp Ser 
            500                 505                 510         


Gln Val Phe Ser Phe Phe Val His Asn Val Ala Thr Glu Arg Leu His 
        515                 520                 525             


Leu Lys Val Leu Asp Asp Asp Gln Glu Cys Ala Leu Gly Met Leu Glu 
    530                 535                 540                 


Val Pro Leu Cys Gln Ile Leu Pro Tyr Ala Asp Leu Thr Leu Glu Gln 
545                 550                 555                 560 


Arg Phe Gln Leu Asp His Ser Gly Leu Asp Ser Leu Ile Ser Met Arg 
                565                 570                 575     


Leu Val Leu Arg Phe Leu Gln Val Glu Glu Arg Glu Leu Gly Ser Pro 
            580                 585                 590         


Tyr Thr Gly Pro Glu Ala Leu Lys Lys Gly Pro Leu Leu Ile Lys Lys 
        595                 600                 605             


Val Ala Thr Asn Gln Gly Pro Lys Ala Gln Pro Gln Glu Glu Gly Pro 
    610                 615                 620                 


Thr Asp Leu Pro Cys Pro Pro Asp Pro Ala Ser Asp Thr Lys Asp Val 
625                 630                 635                 640 


Ser Arg Ser Thr Thr Thr Thr Thr Ser Ala Thr Thr Val Ala Thr Glu 
                645                 650                 655     


Pro Thr Ser Gln Glu Thr Gly Pro Glu Pro Lys Gly Lys Asp Ser Ala 
            660                 665                 670         


Lys Arg Phe Cys Glu Pro Ile Gly Glu Lys Lys Ser Pro Ala Thr Ile 
        675                 680                 685             


Phe Leu Thr Val Pro Gly Pro His Ser Pro Gly Pro Ile Lys Ser Pro 
    690                 695                 700                 


Arg Pro Met Lys Cys Pro Ala Ser Pro Phe Ala Trp Pro Pro Lys Arg 
705                 710                 715                 720 


Leu Ala Pro Ser Met Ser Ser Leu Asn Ser Leu Ala Ser Ser Cys Phe 
                725                 730                 735     


Asp Leu Ala Asp Ile Ser Leu Asn Ile Glu Gly Gly Asp Leu Arg Arg 
            740                 745                 750         


Arg Gln Leu Gly Glu Ile Gln Leu Thr Val Arg Tyr Val Cys Leu Arg 
        755                 760                 765             


Arg Cys Leu Ser Val Leu Ile Asn Gly Cys Arg Asn Leu Thr Pro Cys 
    770                 775                 780                 


Thr Ser Ser Gly Ala Asp Pro Tyr Val Arg Val Tyr Leu Leu Pro Glu 
785                 790                 795                 800 


Arg Lys Trp Ala Cys Arg Lys Lys Thr Ser Val Lys Arg Lys Thr Leu 
                805                 810                 815     


Glu Pro Leu Phe Asp Glu Thr Phe Glu Phe Phe Val Pro Met Glu Glu 
            820                 825                 830         


Val Lys Lys Arg Ser Leu Asp Val Ala Val Lys Asn Ser Arg Pro Leu 
        835                 840                 845             


Gly Ser His Arg Arg Lys Glu Leu Gly Lys Val Leu Ile Asp Leu Ser 
    850                 855                 860                 


Lys Glu Asp Leu Ile Lys Gly Phe Ser Gln Trp Tyr Glu Leu Thr Pro 
865                 870                 875                 880 


Asn Gly Gln Pro Arg Ser 
                885     


<210>  58
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Arg Ala Glu Glu Pro Cys Ala Pro Gly Ala Pro Ser Ala Leu Gly 
1               5                   10                  15      


Ala Gln Arg Thr Pro Gly Pro Glu Leu Arg Leu Ser Ser Gln Leu Leu 
            20                  25                  30          


Pro Glu Leu Cys Thr Phe Val Val Arg Val Leu Phe Tyr Leu Gly Pro 
        35                  40                  45              


Val Tyr Leu Ala Gly Tyr Leu Gly Leu Ser Ile Thr Trp Leu Leu Leu 
    50                  55                  60                  


Gly Ala Leu Leu Trp Met Trp Trp Arg Arg Asn Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Gly Arg Leu Ala Ala Ala Phe Glu Phe Leu Asp Asn Glu Arg Glu Phe 
                85                  90                  95      


Ile Ser Arg Glu Leu Arg Gly Gln His Leu Pro Ala Trp Ile His Phe 
            100                 105                 110         


Pro Asp Val Glu Arg Val Glu Trp Ala Asn Lys Ile Ile Ser Gln Thr 
        115                 120                 125             


Trp Pro Tyr Leu Ser Met Ile Met Glu Ser Lys Phe Arg Glu Lys Leu 
    130                 135                 140                 


Glu Pro Lys Ile Arg Glu Lys Ser Ile His Leu Arg Thr Phe Thr Phe 
145                 150                 155                 160 


Thr Lys Leu Tyr Phe Gly Gln Lys Cys Pro Arg Val Asn Gly Val Lys 
                165                 170                 175     


Ala His Thr Asn Thr Cys Asn Arg Arg Arg Val Thr Val Asp Leu Gln 
            180                 185                 190         


Ile Cys Tyr Ile Gly Asp Cys Glu Ile Ser Val Glu Leu Gln Lys Ile 
        195                 200                 205             


Gln Ala Gly Val Asn Gly Ile Gln Leu Gln Gly Thr Leu Arg Val Ile 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Asp Lys Pro Phe Val Gly Ala Val Thr Val 
225                 230                 235                 240 


Phe Phe Leu Gln Lys Pro His Leu Gln Ile Asn Trp Thr Gly Leu Thr 
                245                 250                 255     


Asn Leu Leu Asp Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu Leu 
            260                 265                 270         


Glu Asp Leu Ile Ala Thr His Leu Val Leu Pro Asn Arg Val Thr Val 
        275                 280                 285             


Pro Val Lys Lys Gly Leu Asp Leu Thr Asn Leu Arg Phe Pro Leu Pro 
    290                 295                 300                 


Cys Gly Val Ile Arg Val His Leu Leu Glu Ala Glu Gln Leu Ala Gln 
305                 310                 315                 320 


Lys Asp Asn Phe Leu Gly Leu Arg Gly Lys Ser Asp Pro Tyr Ala Lys 
                325                 330                 335     


Val Ser Ile Gly Leu Gln His Phe Arg Ser Arg Thr Ile Tyr Arg Asn 
            340                 345                 350         


Leu Asn Pro Thr Trp Asn Glu Val Phe Glu Phe Met Val Tyr Glu Val 
        355                 360                 365             


Pro Gly Gln Asp Leu Glu Val Asp Leu Tyr Asp Glu Asp Thr Asp Arg 
    370                 375                 380                 


Asp Asp Phe Leu Gly Ser Leu Gln Ile Cys Leu Gly Asp Val Met Thr 
385                 390                 395                 400 


Asn Arg Val Val Asp Glu Trp Phe Val Leu Asn Asp Thr Thr Ser Gly 
                405                 410                 415     


Arg Leu His Leu Arg Leu Glu Trp Leu Ser Leu Leu Thr Asp Gln Glu 
            420                 425                 430         


Val Leu Thr Glu Asp His Gly Gly Leu Ser Thr Ala Ile Leu Val Val 
        435                 440                 445             


Phe Leu Glu Ser Ala Cys Asn Leu Pro Arg Asn Pro Phe Asp Tyr Leu 
    450                 455                 460                 


Asn Gly Glu Tyr Arg Ala Lys Lys Leu Ser Arg Phe Ala Arg Val Lys 
465                 470                 475                 480 


Gln Gly Gln Gln Arg Pro Phe Phe Leu Cys Gln Thr Ile Cys Arg Gln 
                485                 490                 495     


Glu Asp Thr Tyr Lys 
            500     


<210>  59
<211>  5992
<212>  DNA
<213>  Homo sapiens

<400>  59
actcactgga gccgagaact ggggcggcgc ggcgcggcgc ggtgcatttc caggcgctgc       60

tctccgtcgc agagaaccct gagctcggcg cgccgagagt cccagcaggg caagggggcg      120

cggcgtcctg gtcctcgagc ttgggagaca gatgcgcatg ggcgtggggg catgcggacc      180

taagctcggg tgaagctctc gggaagggca agactgcggc gacgagatgc gagcagagga      240

gccctgcgcc cccggggccc ccagcgccct gggagcccag cgcacgccgg gccccgagct      300

gcgcctgtcc agccagctgc tgcccgagct ctgtaccttc gtggtgcgcg tgctgttcta      360

cctggggcct gtctacctag ctggctacct ggggctcagc ataacctggt tgctgctcgg      420

cgccctgctg tggatgtggt ggcgcaggaa ccgccgcggg aagcttgggc gcctggccgc      480

cgccttcgaa ttccttgaca atgaacgcga gttcatcagc cgcgagctgc ggggccagca      540

cctgccagcc tggatccact tcccggacgt ggagcgggtc gagtgggcca acaagatcat      600

ctctcagacc tggccctacc taagcatgat catggaaagc aagttccggg agaaacttga      660

gcccaagatc cgagagaaga gcatccacct gaggaccttt acctttacca agctctactt      720

tggacagaag tgtcccaggg tcaacggtgt caaggcacac actaatacgt gcaaccgaag      780

acgtgtgact gtggacctgc agatctgcta catcggggac tgtgagatca gtgtggagct      840

gcagaagatt caggctggtg tgaacgggat ccagttgcag ggcaccctgc gggtcatcct      900

ggagcccctc ctagtggaca agccctttgt gggagccgtg actgtgttct tccttcagaa      960

gccgcaccta cagatcaact ggactggcct gaccaacctg ctggatgcgc cgggaatcaa     1020

tgatgtgtca gacagcttac tggaggacct cattgccacc cacctggtgc tgcccaaccg     1080

tgtgactgtg cctgtgaaga aggggctgga tctgaccaac ctgcgcttcc ctctgccctg     1140

tggggtgatc agagtgcact tgctggaggc agagcagctg gcccagaagg acaactttct     1200

ggggctccga ggcaagtcag atccctacgc caaggtgagc atcggcctac agcatttccg     1260

gagtaggacc atctacagga acctgaaccc cacctggaac gaagtgtttg agttcatggt     1320

gtacgaagtc cctggacagg acctggaggt agacctgtat gatgaggata ccgacaggga     1380

tgacttcctg ggcagcctgc agatctgcct tggagatgtc atgaccaaca gagtggtgga     1440

tgagtggttt gtcctgaatg acacaaccag cgggcggctg cacctgcggc tggagtggct     1500

ttcattgctt actgaccaag aagttctgac tgaggaccat ggtggccttt ccactgccat     1560

tctcgtggtc ttcttggaga gtgcctgcaa cttgccgaga aacccttttg actacctgaa     1620

tggtgaatat cgagccaaaa aactctccag gtttgccaga aacaaggtca gcaaagaccc     1680

ttcttcctat gtcaaactat ctgtaggcaa gaagacacat acaagtaaga cctgtcccca     1740

caacaaggac cctgtgtgga gccaggtgtt ctccttcttt gtgcacaatg tggccactga     1800

gcggctccat ctgaaggtgc ttgatgatga ccaggagtgt gctctgggaa tgctggaggt     1860

ccccctgtgc cagatcctcc cctatgctga cctcactctt gagcagcgct ttcagctgga     1920

ccactcaggc ctggacagcc tcatctccat gaggctggtg cttcggttcc tgcaagtgga     1980

ggaacgagag ctggggagcc catacacagg acctgaagcc ctaaagaaag gccctctgct     2040

catcaagaaa gtggctacca accagggtcc caaagcccaa cctcaggaag aaggccctac     2100

agatttgcca tgtcccccag accctgcttc tgatactaag gacgtatcca ggagtaccac     2160

aaccaccacc agtgctacca ccgttgccac tgagcccaca tcccaagaga caggcccaga     2220

gcctaaaggc aaggacagtg ccaaaaggtt ctgtgagccc atcggggaga agaagagtcc     2280

agccaccatc ttcctgactg tcccaggtcc ccactctcca gggcccatca agtcacccag     2340

acccatgaaa tgccctgcct ccccattcgc atggccgccc aagaggctgg ctcccagcat     2400

gtcctcgctc aactccttgg cctcttcttg ctttgacctg gcagatatca gcctcaacat     2460

tgaaggtggg gacctcaggc gacggcagct gggtgagatt cagctcacag tgcgctatgt     2520

gtgtctgcgg cgctgcctca gcgtgctaat caatggctgc agaaacctaa caccatgtac     2580

cagcagtgga gctgatccct acgtccgtgt ctacttgttg ccagaaagga agtgggcatg     2640

tcgtaagaag acttcagtga agcggaagac cttggaaccc ctgtttgatg agacatttga     2700

attttttgtt cccatggaag aagtaaagaa gaggtcacta gatgttgcag tgaaaaatag     2760

taggccactt ggctcacaca gaagaaagga gttaggaaaa gtactgattg acttatcaaa     2820

agaagatctg attaagggct tttcacaatg gtatgagctg actccaaatg gacagcccag     2880

aagctgatga tgagaattct tatcactcac ctttatatta aaatgtatat atatgtatat     2940

attttttcct ttggatcact tacatccaat atatgtatat tttgtcattt aaatcagaac     3000

aaccacttga aattatatac atacaattct tgtgtggaat ttaactccat gactgaatag     3060

cataaggaag aggttattta aaagcaagaa ctactttttt tggttggatt tttttgttca     3120

agtccagaaa gaaatgttat atttgtgcct actaaattat ccaaacctca gtgtttatat     3180

acttaaacaa gtgccacttt ttagtaggta attatatacc atctgattta ggacttacct     3240

gaatgtatgt accagaaagt gtcctgcctc tggcataggg gctgggggag gtctgtttct     3300

ggagccacta ccagcattcc tgggcagtga ctggccaaag ggaagtcact tttttatgga     3360

aatagaaagt gacccaactc aaaactgcca agagctaaca ctgccaaagc ccttctggct     3420

gccacctgtg gtacttgtat gcctggatat ttgttctttt atttgacctg gagctaaaaa     3480

tgtatttccc tactggcaaa aatgttatac tgatatactt aaataccttg agttaaatac     3540

tcttgtgtag tctaagggcc aaactccagc gtgtagcatt atttccatag gaaaatgcaa     3600

accaagttcc aagcccaggt ctatgtctga ctctcatagc aaagcactgg agactgctga     3660

agagtgtcac catcagagaa aaggaagctt tcagataagt ttaggctatt caacttttct     3720

aaagagatgg ttggttcacc taaataacat gttaaaagca aagtattaaa ttatatgctt     3780

aaacaagcgc ctcttttaca tttcagactt tacaagacca aatatacttc tcatcccctc     3840

caacattcct ggacctcctc ttctctctta ccaacaccaa cactacctgc cgtcagtttt     3900

ctgtctctgc ctctgccttc actgccactt ttctgaagca gggcaacatt cgagaacaaa     3960

gttttgtcat gttactctta ttccagtttc ctgccatctg attcacatgc agatgttcta     4020

ttccagagta gtccaaatac tatgctctgc tgactcaagt catgtctcaa acctatttcc     4080

tctattaagt aagtcagtca atccatagtg aaatggactc ttcctaccgc ctgtagcatt     4140

tactgttgat actgagtatt ttccatttta atagttccca gcctttataa cactaagttt     4200

taagaaatgt tgattaggca tctgctaagg ttacatgcta agcagctact tatattgtat     4260

ttggtattta attttgttta ttctccagtt gaacagtagg gaacaattca agctacttga     4320

attgtttttc accctcacca tccaagaccg tgttaagtac atagaagatg catggtgaaa     4380

ttcgtttctg ctgaggtttc tattttaaat ggcaaattct cataataaaa tggagcattg     4440

atgcctaccc tgtctacctt atgatggcat tctaattgcc ccctaaatag acaagtgcct     4500

tgaaaatgga gaagcaccag agaaataagg gaatgtatca tatgtacatc gaaacattag     4560

caaccctaaa acagctaatc aaaatggcag ataagtgaaa acctacccct cttcttccaa     4620

acttaaacca caaacattta ttttaaacgt ggtcaattga accgttttta cctgtgtcag     4680

gcaacacagg taaatacctg gtgatggtct gaagaggagt taaaatgttg aagggaacca     4740

gaattttagt acacagcaga caggaggcaa ggttatatag gcgctgtgtg aggggcaggg     4800

agcctgaaaa gttgttaata ccttggctgc cactgaggac aagaattggt tttcagcagt     4860

gggtggaaac aatcagctaa tatgcaggag catagggtct gaagttaaca tcatcttggt     4920

acagaaaccc ccaaacctaa gacggaatgt gaatattggt ttagaacctg gaagcctgtg     4980

aagccttgat ggaggcaacc ataaaattgg ccccacaggg ttgccactcc catccagggc     5040

acatatgcga caactgcagc agatggctgt cactaaaggg aaactcacgg gcaaaaataa     5100

attatgaaac aaaacaaaaa cagactttaa aaaaaataca aagtacacag gaatatcaaa     5160

ctgaaaaata gccatagata atatttcagc cagaaggaaa atgtaccagt aaggcagaaa     5220

tagcatgtga gaagcagtgg aaagcaaaga aatccataaa atacattggc aaacctaagc     5280

aagttttgat gatgattgtt cacaagatat aaacaaataa ccaaagattt ttgcaagggt     5340

tcagaaacat agtagaacta aaatgttagt actaacaact aagaaggggc agctaggctg     5400

attaagaaag taagtattca agaccatatc ttatttagga agctaaagat actcatctta     5460

aaaatataac tgtgtcagtc actaattcat tacctctcag cttcaaattg acgtctgtct     5520

cctttgctgc tttcccggca ggctgatgtt tggctttgcc aatagggggc gatggaagga     5580

cactctatag caggaagaag gggcttttct tctgatgttt tccatggctg ctagctaatt     5640

ggcatacaga gctgttctca atcaatcacc taagtacccc cacagtttac ccttggctca     5700

tggccttcat gttttatcag caggcaacac cttttggcaa gtttcttagc cacaagtggg     5760

ttgcatggtc ctatggctgc cagcggaaat ctaaatctca gcctggtagg gaggcactta     5820

gtttctaact tcctttcttg ttcactctcc cttacccctg ggggtaagga tctgcatcct     5880

gaagttgata ttctgtatcc cctagagtcc acttctaccc cgtttagtag taaatacaag     5940

aattgctaac tagtaaaagg tggttaagtt tttcaaaaaa aaaaaaaaaa aa             5992


<210>  60
<211>  5110
<212>  DNA
<213>  Homo sapiens

<400>  60
actcactgga gccgagaact ggggcggcgc ggcgcggcgc ggtgcatttc caggcgctgc       60

tctccgtcgc agagaaccct gagctcggcg cgccgagagt cccagcaggg caagggggcg      120

cggcgtcctg gtcctcgagc ttgggagaca gatgcgcatg ggcgtggggg catgcggacc      180

taagctcggg tgaagctctc gggaagggca agactgcggc gacgagatgc gagcagagga      240

gccctgcgcc cccggggccc ccagcgccct gggagcccag cgcacgccgg gccccgagct      300

gcgcctgtcc agccagctgc tgcccgagct ctgtaccttc gtggtgcgcg tgctgttcta      360

cctggggcct gtctacctag ctggctacct ggggctcagc ataacctggt tgctgctcgg      420

cgccctgctg tggatgtggt ggcgcaggaa ccgccgcggg aagcttgggc gcctggccgc      480

cgccttcgaa ttccttgaca atgaacgcga gttcatcagc cgcgagctgc ggggccagca      540

cctgccagcc tggatccact tcccggacgt ggagcgggtc gagtgggcca acaagatcat      600

ctctcagacc tggccctacc taagcatgat catggaaagc aagttccggg agaaacttga      660

gcccaagatc cgagagaaga gcatccacct gaggaccttt acctttacca agctctactt      720

tggacagaag tgtcccaggg tcaacggtgt caaggcacac actaatacgt gcaaccgaag      780

acgtgtgact gtggacctgc agatctgcta catcggggac tgtgagatca gtgtggagct      840

gcagaagatt caggctggtg tgaacgggat ccagttgcag ggcaccctgc gggtcatcct      900

ggagcccctc ctagtggaca agccctttgt gggagccgtg actgtgttct tccttcagaa      960

gccgcaccta cagatcaact ggactggcct gaccaacctg ctggatgcgc cgggaatcaa     1020

tgatgtgtca gacagcttac tggaggacct cattgccacc cacctggtgc tgcccaaccg     1080

tgtgactgtg cctgtgaaga aggggctgga tctgaccaac ctgcgcttcc ctctgccctg     1140

tggggtgatc agagtgcact tgctggaggc agagcagctg gcccagaagg acaactttct     1200

ggggctccga ggcaagtcag atccctacgc caaggtgagc atcggcctac agcatttccg     1260

gagtaggacc atctacagga acctgaaccc cacctggaac gaagtgtttg agttcatggt     1320

gtacgaagtc cctggacagg acctggaggt agacctgtat gatgaggata ccgacaggga     1380

tgacttcctg ggcagcctgc agatctgcct tggagatgtc atgaccaaca gagtggtgga     1440

tgagtggttt gtcctgaatg acacaaccag cgggcggctg cacctgcggc tggagtggct     1500

ttcattgctt actgaccaag aagttctgac tgaggaccat ggtggccttt ccactgccat     1560

tctcgtggtc ttcttggaga gtgcctgcaa cttgccgaga aacccttttg actacctgaa     1620

tggtgaatat cgagccaaaa aactctccag gtttgccaga aacaaggtca gcaaagaccc     1680

ttcttcctat gtcaaactat ctgtaggcaa gaagacacat acaagtaaga cctgtcccca     1740

caacaaggac cctgtgtgga gccaggtgtt ctccttcttt gtgcacaatg tggccactga     1800

gcggctccat ctgaaggtgc ttgatgatga ccaggagtgt gctctgggaa tgctggaggt     1860

ccccctgtgc cagatcctcc cctatgctga cctcactctt gagcagcgct ttcagctgga     1920

ccactcaggc ctggacagcc tcatctccat gaggctggtg cttcggttcc tgcaagtgga     1980

ggaacgagag ctggggagcc catacacagg acctgaagcc ctaaagaaag gccctctgct     2040

catcaagaaa gtggctacca accagggtcc caaagcccaa cctcaggaag aaggccctac     2100

agatttgcca tgtcccccag accctgcttc tgatactaag gacgtatcca ggagtaccac     2160

aaccaccacc agtgctacca ccgttgccac tgagcccaca tcccaagaga caggcccaga     2220

gcctaaaggc aaggacagtg ccaaaaggtt ctgtgagccc atcggggaga agaagagtcc     2280

agccaccatc ttcctgactg tcccaggtcc ccactctcca gggcccatca agtcacccag     2340

acccatgaaa tgccctgcct ccccattcgc atggccgccc aagaggctgg ctcccagcat     2400

gtcctcgctc aactccttgg cctcttcttg ctttgacctg gcagatatca gcctcaacat     2460

tgaaggtggg gacctcaggc gacggcagct gggtgagatt cagctcacag tgcgctatgt     2520

gtgtctgcgg cgctgcctca gcgtgctaat caatggctgc agaaacctaa caccatgtac     2580

cagcagtgga gctgatccct acgtccgtgt ctacttgttg ccagaaagga agtgggcatg     2640

tcgtaagaag acttcagtga agcggaagac cttggaaccc ctgtttgatg agacatttga     2700

attttttgtt cccatggaag aagtaaagaa gaggtcacta gatgttgcag tgaaaaatag     2760

taggccactt ggctcacaca gaagaaagga gttaggaaaa gtactgattg acttatcaaa     2820

agaagatctg attaagggct tttcacaatg gtatgagctg actccaaatg gacagcccag     2880

aagctgatga tgagaattct tatcactcac ctttatatta aaatacttta caagaccaaa     2940

tatacttctc atcccctcca acattcctgg acctcctctt ctctcttacc aacaccaaca     3000

ctacctgccg tcagttttct gtctctgcct ctgccttcac tgccactttt ctgaagcagg     3060

gcaacattcg agaacaaagt tttgtcatgt tactcttatt ccagtttcct gccatctgat     3120

tcacatgcag atgttctatt ccagagtagt ccaaatacta tgctctgctg actcaagtca     3180

tgtctcaaac ctatttcctc tattaagtaa gtcagtcaat ccatagtgaa atggactctt     3240

cctaccgcct gtagcattta ctgttgatac tgagtatttt ccattttaat agttcccagc     3300

ctttataaca ctaagtttta agaaatgttg attaggcatc tgctaaggtt acatgctaag     3360

cagctactta tattgtattt ggtatttaat tttgtttatt ctccagttga acagtaggga     3420

acaattcaag ctacttgaat tgtttttcac cctcaccatc caagaccgtg ttaagtacat     3480

agaagatgca tggtgaaatt cgtttctgct gaggtttcta ttttaaatgg caaattctca     3540

taataaaatg gagcattgat gcctaccctg tctaccttat gatggcattc taattgcccc     3600

ctaaatagac aagtgccttg aaaatggaga agcaccagag aaataaggga atgtatcata     3660

tgtacatcga aacattagca accctaaaac agctaatcaa aatggcagat aagtgaaaac     3720

ctacccctct tcttccaaac ttaaaccaca aacatttatt ttaaacgtgg tcaattgaac     3780

cgtttttacc tgtgtcaggc aacacaggta aatacctggt gatggtctga agaggagtta     3840

aaatgttgaa gggaaccaga attttagtac acagcagaca ggaggcaagg ttatataggc     3900

gctgtgtgag gggcagggag cctgaaaagt tgttaatacc ttggctgcca ctgaggacaa     3960

gaattggttt tcagcagtgg gtggaaacaa tcagctaata tgcaggagca tagggtctga     4020

agttaacatc atcttggtac agaaaccccc aaacctaaga cggaatgtga atattggttt     4080

agaacctgga agcctgtgaa gccttgatgg aggcaaccat aaaattggcc ccacagggtt     4140

gccactccca tccagggcac atatgcgaca actgcagcag atggctgtca ctaaagggaa     4200

actcacgggc aaaaataaat tatgaaacaa aacaaaaaca gactttaaaa aaaatacaaa     4260

gtacacagga atatcaaact gaaaaatagc catagataat atttcagcca gaaggaaaat     4320

gtaccagtaa ggcagaaata gcatgtgaga agcagtggaa agcaaagaaa tccataaaat     4380

acattggcaa acctaagcaa gttttgatga tgattgttca caagatataa acaaataacc     4440

aaagattttt gcaagggttc agaaacatag tagaactaaa atgttagtac taacaactaa     4500

gaaggggcag ctaggctgat taagaaagta agtattcaag accatatctt atttaggaag     4560

ctaaagatac tcatcttaaa aatataactg tgtcagtcac taattcatta cctctcagct     4620

tcaaattgac gtctgtctcc tttgctgctt tcccggcagg ctgatgtttg gctttgccaa     4680

tagggggcga tggaaggaca ctctatagca ggaagaaggg gcttttcttc tgatgttttc     4740

catggctgct agctaattgg catacagagc tgttctcaat caatcaccta agtaccccca     4800

cagtttaccc ttggctcatg gccttcatgt tttatcagca ggcaacacct tttggcaagt     4860

ttcttagcca caagtgggtt gcatggtcct atggctgcca gcggaaatct aaatctcagc     4920

ctggtaggga ggcacttagt ttctaacttc ctttcttgtt cactctccct tacccctggg     4980

ggtaaggatc tgcatcctga agttgatatt ctgtatcccc tagagtccac ttctaccccg     5040

tttagtagta aatacaagaa ttgctaacta gtaaaaggtg gttaagtttt tcaaaaaaaa     5100

aaaaaaaaaa                                                            5110


<210>  61
<211>  5036
<212>  DNA
<213>  Homo sapiens

<400>  61
actcactgga gccgagaact ggggcggcgc ggcgcggcgc ggtgcatttc caggcgctgc       60

tctccgtcgc agagaaccct gagctcggcg cgccgagagt cccagcaggg caagggggcg      120

cggcgtcctg gtcctcgagc ttgggagaca gatgcgcatg ggcgtggggg catgcggacc      180

taagctcggg tgaagctctc gggaagggca agactgcggc gacgagatgc gagcagagga      240

gccctgcgcc cccggggccc ccagcgccct gggagcccag cgcacgccgg gccccgagct      300

gcgcctgtcc agccagctgc tgcccgagct ctgtaccttc gtggtgcgcg tgctgttcta      360

cctggggcct gtctacctag ctggctacct ggggctcagc ataacctggt tgctgctcgg      420

cgccctgctg tggatgtggt ggcgcaggaa ccgccgcggg aagcttgggc gcctggccgc      480

cgccttcgaa ttccttgaca atgaacgcga gttcatcagc cgcgagctgc ggggccagca      540

cctgccagcc tggatccact tcccggacgt ggagcgggtc gagtgggcca acaagatcat      600

ctctcagacc tggccctacc taagcatgat catggaaagc aagttccggg agaaacttga      660

gcccaagatc cgagagaaga gcatccacct gaggaccttt acctttacca agctctactt      720

tggacagaag tgtcccaggg tcaacggtgt caaggcacac actaatacgt gcaaccgaag      780

acgtgtgact gtggacctgc agatctgcta catcggggac tgtgagatca gtgtggagct      840

gcagaagatt caggctggtg tgaacgggat ccagttgcag ggcaccctgc gggtcatcct      900

ggagcccctc ctagtggaca agccctttgt gggagccgtg actgtgttct tccttcagaa      960

gccgcaccta cagatcaact ggactggcct gaccaacctg ctggatgcgc cgggaatcaa     1020

tgatgtgtca gacagcttac tggaggacct cattgccacc cacctggtgc tgcccaaccg     1080

tgtgactgtg cctgtgaaga aggggctgga tctgaccaac ctgcgcttcc ctctgccctg     1140

tggggtgatc agagtgcact tgctggaggc agagcagctg gcccagaagg acaactttct     1200

ggggctccga ggcaagtcag atccctacgc caaggtgagc atcggcctac agcatttccg     1260

gagtaggacc atctacagga acctgaaccc cacctggaac gaagtgtttg agttcatggt     1320

gtacgaagtc cctggacagg acctggaggt agacctgtat gatgaggata ccgacaggga     1380

tgacttcctg ggcagcctgc agatctgcct tggagatgtc atgaccaaca gagtggtgga     1440

tgagtggttt gtcctgaatg acacaaccag cgggcggctg cacctgcggc tggagtggct     1500

ttcattgctt actgaccaag aagttctgac tgaggaccat ggtggccttt ccactgccat     1560

tctcgtggtc ttcttggaga gtgcctgcaa cttgccgaga aacccttttg actacctgaa     1620

tggtgaatat cgagccaaaa aactctccag gtttgccaga aacaaggtca gcaaagaccc     1680

ttcttcctat gtcaaactat ctgtaggcaa gaagacacat acaagtaaga cctgtcccca     1740

caacaaggac cctgtgtgga gccaggtgtt ctccttcttt gtgcacaatg tggccactga     1800

gcggctccat ctgaaggtgc ttgatgatga ccaggagtgt gctctgggaa tgctggaggt     1860

ccccctgtgc cagatcctcc cctatgctga cctcactctt gagcagcgct ttcagctgga     1920

ccactcaggc ctggacagcc tcatctccat gaggctggtg cttcggttcc tgcaagtgga     1980

ggaacgagag ctggggagcc catacacagg acctgaagcc ctaaagaaag gccctctgct     2040

catcaagaaa gtggctacca accagggtcc caaagcccaa cctcaggaag aaggccctac     2100

agatttgcca tgtcccccag accctgcttc tgatactaag gacgtatcca ggagtaccac     2160

aaccaccacc agtgctacca ccgttgccac tgagcccaca tcccaagaga caggcccaga     2220

gcctaaaggc aaggacagtg ccaaaaggtt ctgtgagccc atcggggaga agaagagtcc     2280

agccaccatc ttcctgactg tcccaggtcc ccactctcca gggcccatca agtcacccag     2340

acccatgaaa tgccctgcct ccccattcgc atggccgccc aagaggctgg ctcccagcat     2400

gtcctcgctc aactccttgg cctcttcttg ctttgacctg gcagatatca gcctcaacat     2460

tgaaggtggg gacctcaggc gacggcagct gggtgagatt cagctcacag tgcgctatgt     2520

gtgtctgcgg cgctgcctca gcgtgctaat caatggctgc agaaacctaa caccatgtac     2580

cagcagtgga gctgatccct acgtccgtgt ctacttgttg ccagaaagga agtgggcatg     2640

tcgtaagaag acttcagtga agcggaagac cttggaaccc ctgtttgatg agacatttga     2700

attttttgtt cccatggaag aagtaaagaa gaggtcacta gatgttgcag tgaaaaatag     2760

taggccactt ggctcacaca gaagaaagga gttaggaaaa gtactgattg acttatcaaa     2820

agaagatctg attaagggct tttcacaatg actttacaag accaaatata cttctcatcc     2880

cctccaacat tcctggacct cctcttctct cttaccaaca ccaacactac ctgccgtcag     2940

ttttctgtct ctgcctctgc cttcactgcc acttttctga agcagggcaa cattcgagaa     3000

caaagttttg tcatgttact cttattccag tttcctgcca tctgattcac atgcagatgt     3060

tctattccag agtagtccaa atactatgct ctgctgactc aagtcatgtc tcaaacctat     3120

ttcctctatt aagtaagtca gtcaatccat agtgaaatgg actcttccta ccgcctgtag     3180

catttactgt tgatactgag tattttccat tttaatagtt cccagccttt ataacactaa     3240

gttttaagaa atgttgatta ggcatctgct aaggttacat gctaagcagc tacttatatt     3300

gtatttggta tttaattttg tttattctcc agttgaacag tagggaacaa ttcaagctac     3360

ttgaattgtt tttcaccctc accatccaag accgtgttaa gtacatagaa gatgcatggt     3420

gaaattcgtt tctgctgagg tttctatttt aaatggcaaa ttctcataat aaaatggagc     3480

attgatgcct accctgtcta ccttatgatg gcattctaat tgccccctaa atagacaagt     3540

gccttgaaaa tggagaagca ccagagaaat aagggaatgt atcatatgta catcgaaaca     3600

ttagcaaccc taaaacagct aatcaaaatg gcagataagt gaaaacctac ccctcttctt     3660

ccaaacttaa accacaaaca tttattttaa acgtggtcaa ttgaaccgtt tttacctgtg     3720

tcaggcaaca caggtaaata cctggtgatg gtctgaagag gagttaaaat gttgaaggga     3780

accagaattt tagtacacag cagacaggag gcaaggttat ataggcgctg tgtgaggggc     3840

agggagcctg aaaagttgtt aataccttgg ctgccactga ggacaagaat tggttttcag     3900

cagtgggtgg aaacaatcag ctaatatgca ggagcatagg gtctgaagtt aacatcatct     3960

tggtacagaa acccccaaac ctaagacgga atgtgaatat tggtttagaa cctggaagcc     4020

tgtgaagcct tgatggaggc aaccataaaa ttggccccac agggttgcca ctcccatcca     4080

gggcacatat gcgacaactg cagcagatgg ctgtcactaa agggaaactc acgggcaaaa     4140

ataaattatg aaacaaaaca aaaacagact ttaaaaaaaa tacaaagtac acaggaatat     4200

caaactgaaa aatagccata gataatattt cagccagaag gaaaatgtac cagtaaggca     4260

gaaatagcat gtgagaagca gtggaaagca aagaaatcca taaaatacat tggcaaacct     4320

aagcaagttt tgatgatgat tgttcacaag atataaacaa ataaccaaag atttttgcaa     4380

gggttcagaa acatagtaga actaaaatgt tagtactaac aactaagaag gggcagctag     4440

gctgattaag aaagtaagta ttcaagacca tatcttattt aggaagctaa agatactcat     4500

cttaaaaata taactgtgtc agtcactaat tcattacctc tcagcttcaa attgacgtct     4560

gtctcctttg ctgctttccc ggcaggctga tgtttggctt tgccaatagg gggcgatgga     4620

aggacactct atagcaggaa gaaggggctt ttcttctgat gttttccatg gctgctagct     4680

aattggcata cagagctgtt ctcaatcaat cacctaagta cccccacagt ttacccttgg     4740

ctcatggcct tcatgtttta tcagcaggca acaccttttg gcaagtttct tagccacaag     4800

tgggttgcat ggtcctatgg ctgccagcgg aaatctaaat ctcagcctgg tagggaggca     4860

cttagtttct aacttccttt cttgttcact ctcccttacc cctgggggta aggatctgca     4920

tcctgaagtt gatattctgt atcccctaga gtccacttct accccgttta gtagtaaata     4980

caagaattgc taactagtaa aaggtggtta agtttttcaa aaaaaaaaaa aaaaaa         5036


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for MMP13

<400>  62
atgaagaccc caaccctaaa ca                                                22


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-sense primer for MMP13

<400>  63
cggagactgg taatggcatc a                                                 21


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for STMN2

<400>  64
aagccccacg aactttag                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-sense primer for STMN2

<400>  65
cgtgttccct cttctctg                                                     18


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for THBS4

<400>  66
agagaggcag ggggatgtg                                                    19


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-sense primer for THBS4

<400>  67
ttcttcgtcg gggtaactgt c                                                 21


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense primer for OMD positive tissue control

<400>  68
cagtaacaga ttagaatcaa tgcc                                              24


<210>  69
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-sense primer for OMD positive tissue control

<400>  69
gacattctta gagtatgaag ttttgga                                           27


