                         SEQUENCE LISTING

<110>  SERVICIO ANDALUZ DE SALUD
       UNIVERSIDAD DE CRDOBA
 
<120>  xx

<130>  FIBICO-16023

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  2
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser Pro Leu Gly Lys Pro 
625                 630                 635                 640 


Ser Leu Ser Pro 
                


<210>  3
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu 
            100                 105                 110         


Thr Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu 
            260                 265                 270         


Phe Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg 
        275                 280                 285             


Pro Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp 
    290                 295                 300                 


Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys 
305                 310                 315                 320 


Thr Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser 
                325                 330                 335     


Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser 
            340                 345                 350         


Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr 
        355                 360                 365             


Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn 
    370                 375                 380                 


Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val 
385                 390                 395                 400 


Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His 
                405                 410                 415     


Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly 
            420                 425                 430         


Asn Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe 
        435                 440                 445             


Pro Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile 
    450                 455                 460                 


Ser Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln 
465                 470                 475                 480 


Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser 
                485                 490                 495     


Asn Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys 
            500                 505                 510         


Ile His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile 
        515                 520                 525             


Gln Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp 
    530                 535                 540                 


Thr Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val 
545                 550                 555                 560 


Leu Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg 
                565                 570                 575     


Cys Glu 
        


<210>  4
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly 
            20                  25                  30          


Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly 
        35                  40                  45              


Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn 
                85                  90                  95      


Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr 
            100                 105                 110         


Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser 
        115                 120                 125             


Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys 
    130                 135                 140                 


Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser 
145                 150                 155                 160 


Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr 
                165                 170                 175     


Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys 
            180                 185                 190         


Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu 
        195                 200                 205             


Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe 
            260                 265                 270         


Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro 
        275                 280                 285             


Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln 
    290                 295                 300                 


Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser Lys 
                325                 330                 335     


Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile 
            340                 345                 350         


Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala 
        355                 360                 365             


Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly 
    370                 375                 380                 


Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe 
385                 390                 395                 400 


Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp 
                405                 410                 415     


Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn 
            420                 425                 430         


Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro 
        435                 440                 445             


Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser 
    450                 455                 460                 


Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser 
465                 470                 475                 480 


Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn 
                485                 490                 495     


Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile 
            500                 505                 510         


His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln 
        515                 520                 525             


Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr 
    530                 535                 540                 


Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu 
545                 550                 555                 560 


Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys 
                565                 570                 575     


Glu 
    


<210>  5
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  6
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Asn Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210>  7
<211>  2386
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    2075                 2080                 2085             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2090                 2095                 2100             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2105                 2110                 2115             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2120                 2125                 2130             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2135                 2140                 2145             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2150                 2155                 2160             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2165                 2170                 2175             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2180                 2185                 2190             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2195                 2200                 2205             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2210                 2215                 2220             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2225                 2230                 2235             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2240                 2245                 2250             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2255                 2260                 2265             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2270                 2275                 2280             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2285                 2290                 2295             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2300                 2305                 2310             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2315                 2320                 2325             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2330                 2335                 2340             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2345                 2350                 2355             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2360                 2365                 2370             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2375                 2380                 2385     


<210>  8
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Leu Arg Leu Asp Thr Thr Pro Ser Cys Asn Ser Ala Arg Pro 
1               5                   10                  15      


Leu His Ala Leu Gln Val Leu Leu Leu Leu Ser Leu Leu Leu Thr Ala 
            20                  25                  30          


Leu Ala Ser Ser Thr Lys Gly Gln Thr Lys Arg Asn Leu Ala Lys Gly 
        35                  40                  45              


Lys Glu Glu Ser Leu Asp Ser Asp Leu Tyr Ala Glu Leu Arg Cys Met 
    50                  55                  60                  


Cys Ile Lys Thr Thr Ser Gly Ile His Pro Lys Asn Ile Gln Ser Leu 
65                  70                  75                  80  


Glu Val Ile Gly Lys Gly Thr His Cys Asn Gln Val Glu Val Ile Ala 
                85                  90                  95      


Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu Asp Pro Asp Ala Pro Arg 
            100                 105                 110         


Ile Lys Lys Ile Val Gln Lys Lys Leu Ala Gly Asp Glu Ser Ala Asp 
        115                 120                 125             


<210>  9
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Glu Thr Ser Arg Thr Ala Phe Gly Gly Arg Arg Ala Val Pro 
1               5                   10                  15      


Pro Asn Asn Ser Asn Ala Ala Glu Asp Asp Leu Pro Thr Val Glu Leu 
            20                  25                  30          


Gln Gly Val Val Pro Arg Gly Val Asn Leu Gln Glu Phe Leu Asn Val 
        35                  40                  45              


Thr Ser Val His Leu Phe Lys Glu Arg Trp Asp Thr Asn Lys Val Asp 
    50                  55                  60                  


His His Thr Asp Lys Tyr Glu Asn Asn Lys Leu Ile Val Arg Arg Gly 
65                  70                  75                  80  


Gln Ser Phe Tyr Val Gln Ile Asp Phe Ser Arg Pro Tyr Asp Pro Arg 
                85                  90                  95      


Arg Asp Leu Phe Arg Val Glu Tyr Val Ile Gly Arg Tyr Pro Gln Glu 
            100                 105                 110         


Asn Lys Gly Thr Tyr Ile Pro Val Pro Ile Val Ser Glu Leu Gln Ser 
        115                 120                 125             


Gly Lys Trp Gly Ala Lys Ile Val Met Arg Glu Asp Arg Ser Val Arg 
    130                 135                 140                 


Leu Ser Ile Gln Ser Ser Pro Lys Cys Ile Val Gly Lys Phe Arg Met 
145                 150                 155                 160 


Tyr Val Ala Val Trp Thr Pro Tyr Gly Val Leu Arg Thr Ser Arg Asn 
                165                 170                 175     


Pro Glu Thr Asp Thr Tyr Ile Leu Phe Asn Pro Trp Cys Glu Asp Asp 
            180                 185                 190         


Ala Val Tyr Leu Asp Asn Glu Lys Glu Arg Glu Glu Tyr Val Leu Asn 
        195                 200                 205             


Asp Ile Gly Val Ile Phe Tyr Gly Glu Val Asn Asp Ile Lys Thr Arg 
    210                 215                 220                 


Ser Trp Ser Tyr Gly Gln Phe Glu Asp Gly Ile Leu Asp Thr Cys Leu 
225                 230                 235                 240 


Tyr Val Met Asp Arg Ala Gln Met Asp Leu Ser Gly Arg Gly Asn Pro 
                245                 250                 255     


Ile Lys Val Ser Arg Val Gly Ser Ala Met Val Asn Ala Lys Asp Asp 
            260                 265                 270         


Glu Gly Val Leu Val Gly Ser Trp Asp Asn Ile Tyr Ala Tyr Gly Val 
        275                 280                 285             


Pro Pro Ser Ala Trp Thr Gly Ser Val Asp Ile Leu Leu Glu Tyr Arg 
    290                 295                 300                 


Ser Ser Glu Asn Pro Val Arg Tyr Gly Gln Cys Trp Val Phe Ala Gly 
305                 310                 315                 320 


Val Phe Asn Thr Phe Leu Arg Cys Leu Gly Ile Pro Ala Arg Ile Val 
                325                 330                 335     


Thr Asn Tyr Phe Ser Ala His Asp Asn Asp Ala Asn Leu Gln Met Asp 
            340                 345                 350         


Ile Phe Leu Glu Glu Asp Gly Asn Val Asn Ser Lys Leu Thr Lys Asp 
        355                 360                 365             


Ser Val Trp Asn Tyr His Cys Trp Asn Glu Ala Trp Met Thr Arg Pro 
    370                 375                 380                 


Asp Leu Pro Val Gly Phe Gly Gly Trp Gln Ala Val Asp Ser Thr Pro 
385                 390                 395                 400 


Gln Glu Asn Ser Asp Gly Met Tyr Arg Cys Gly Pro Ala Ser Val Gln 
                405                 410                 415     


Ala Ile Lys His Gly His Val Cys Phe Gln Phe Asp Ala Pro Phe Val 
            420                 425                 430         


Phe Ala Glu Val Asn Ser Asp Leu Ile Tyr Ile Thr Ala Lys Lys Asp 
        435                 440                 445             


Gly Thr His Val Val Glu Asn Val Asp Ala Thr His Ile Gly Lys Leu 
    450                 455                 460                 


Ile Val Thr Lys Gln Ile Gly Gly Asp Gly Met Met Asp Ile Thr Asp 
465                 470                 475                 480 


Thr Tyr Lys Phe Gln Glu Gly Gln Glu Glu Glu Arg Leu Ala Leu Glu 
                485                 490                 495     


Thr Ala Leu Met Tyr Gly Ala Lys Lys Pro Leu Asn Thr Glu Gly Val 
            500                 505                 510         


Met Lys Ser Arg Ser Asn Val Asp Met Asp Phe Glu Val Glu Asn Ala 
        515                 520                 525             


Val Leu Gly Lys Asp Phe Lys Leu Ser Ile Thr Phe Arg Asn Asn Ser 
    530                 535                 540                 


His Asn Arg Tyr Thr Ile Thr Ala Tyr Leu Ser Ala Asn Ile Thr Phe 
545                 550                 555                 560 


Tyr Thr Gly Val Pro Lys Ala Glu Phe Lys Lys Glu Thr Phe Asp Val 
                565                 570                 575     


Thr Leu Glu Pro Leu Ser Phe Lys Lys Glu Ala Val Leu Ile Gln Ala 
            580                 585                 590         


Gly Glu Tyr Met Gly Gln Leu Leu Glu Gln Ala Ser Leu His Phe Phe 
        595                 600                 605             


Val Thr Ala Arg Ile Asn Glu Thr Arg Asp Val Leu Ala Lys Gln Lys 
    610                 615                 620                 


Ser Thr Val Leu Thr Ile Pro Glu Ile Ile Ile Lys Val Arg Gly Thr 
625                 630                 635                 640 


Gln Val Val Gly Ser Asp Met Thr Val Thr Val Gln Phe Thr Asn Pro 
                645                 650                 655     


Leu Lys Glu Thr Leu Arg Asn Val Trp Val His Leu Asp Gly Pro Gly 
            660                 665                 670         


Val Thr Arg Pro Met Lys Lys Met Phe Arg Glu Ile Arg Pro Asn Ser 
        675                 680                 685             


Thr Val Gln Trp Glu Glu Val Cys Arg Pro Trp Val Ser Gly His Arg 
    690                 695                 700                 


Lys Leu Ile Ala Ser Met Ser Ser Asp Ser Leu Arg His Val Tyr Gly 
705                 710                 715                 720 


Glu Leu Asp Val Gln Ile Gln Arg Arg Pro Ser Met 
                725                 730         


<210>  10
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly Arg Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  11
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Leu Phe Ser 
65                  70                  75                  80  


Ala Glu Leu 
            


<210>  12
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210>  13
<211>  3692
<212>  DNA
<213>  Homo sapiens

<400>  13
aggatgggaa ctaggagtgg cagcaatcct ttctttcagc tggagtgctc ctcaggagcc       60

agccccaccc ttagaaaaga tgttttccat gaggatcgtc tgcctggtcc taagtgtggt      120

gggcacagca tggactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt      180

gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt      240

ctgctctgat gaagactgga actacaaatg cccttctggc tgcaggatga aagggttgat      300

tgatgaagtc aatcaagatt ttacaaacag aataaataag ctcaaaaatt cactatttga      360

atatcagaag aacaataagg attctcattc gttgaccact aatataatgg aaattttgag      420

aggcgatttt tcctcagcca ataaccgtga taatacctac aaccgagtgt cagaggatct      480

gagaagcaga attgaagtcc tgaagcgcaa agtcatagaa aaagtacagc atatccagct      540

tctgcagaaa aatgttagag ctcagttggt tgatatgaaa cgactggagg tggacattga      600

tattaagatc cgatcttgtc gagggtcatg cagtagggct ttagctcgtg aagtagatct      660

gaaggactat gaagatcagc agaagcaact tgaacaggtc attgccaaag acttacttcc      720

ctctagagat aggcaacact taccactgat aaaaatgaaa ccagttccag acttggttcc      780

cggaaatttt aagagccagc ttcagaaggt acccccagag tggaaggcat taacagacat      840

gccgcagatg agaatggagt tagagagacc tggtggaaat gagattactc gaggaggctc      900

cacctcttat ggaaccggat cagagacgga aagccccagg aaccctagca gtgctggaag      960

ctggaactct gggagctctg gacctggaag tactggaaac cgaaaccctg ggagctctgg     1020

gactggaggg actgcaacct ggaaacctgg gagctctgga cctggaagta ctggaagctg     1080

gaactctggg agctctggaa ctggaagtac tggaaaccaa aaccctggga gccctagacc     1140

tggtagtacc ggaacctgga atcctggcag ctctgaacgc ggaagtgctg ggcactggac     1200

ctctgagagc tctgtatctg gtagtactgg acaatggcac tctgaatctg gaagttttag     1260

gccagatagc ccaggctctg ggaacgcgag gcctaacaac ccagactggg gcacatttga     1320

agaggtgtca ggaaatgtaa gtccagggac aaggagagag taccacacag aaaaactggt     1380

cacttctaaa ggagataaag agctcaggac tggtaaagag aaggtcacct ctggtagcac     1440

aaccaccacg cgtcgttcat gctctaaaac cgttactaag actgttattg gtcctgatgg     1500

tcacaaagaa gttaccaaag aagtggtgac ctccgaagat ggttctgact gtcccgaggc     1560

aatggattta ggcacattgt ctggcatagg tactctggat gggttccgcc ataggcaccc     1620

tgatgaagct gccttcttcg acactgcctc aactggaaaa acattcccag gtttcttctc     1680

acctatgtta ggagagtttg tcagtgagac tgagtctagg ggctcagaat ctggcatctt     1740

cacaaataca aaggaatcca gttctcatca ccctgggata gctgaattcc cttcccgtgg     1800

taaatcttca agttacagca aacaatttac tagtagcacg agttacaaca gaggagactc     1860

cacatttgaa agcaagagct ataaaatggc agatgaggcc ggaagtgaag ccgatcatga     1920

aggaacacat agcaccaaga gaggccatgc taaatctcgc cctgtcagag actgtgatga     1980

tgtcctccaa acacatcctt caggtaccca aagtggcatt ttcaatatca agctaccggg     2040

atccagtaag attttttctg tttattgcga tcaagagacc agtttgggag gatggctttt     2100

gatccagcaa agaatggatg gatcactgaa ttttaaccgg acctggcaag actacaagag     2160

aggtttcggc agcctgaatg acgaggggga aggagaattc tggctaggca atgactacct     2220

ccacttacta acccaaaggg gctctgttct tagggttgaa ttagaggact gggctgggaa     2280

tgaagcttat gcagaatatc acttccgggt aggctctgag gctgaaggct atgccctcca     2340

agtctcctcc tatgaaggca ctgcgggtga tgctctgatt gagggttccg tagaggaagg     2400

ggcagagtac acctctcaca acaacatgca gttcagcacc tttgacaggg atgcagacca     2460

gtgggaagag aactgtgcag aagtctatgg gggaggctgg tggtataata actgccaagc     2520

agccaatctc aatggaatct actaccctgg gggctcctat gacccaagga ataacagtcc     2580

ttatgagatt gagaatggag tggtctgggt ttcctttaga ggggcagatt attccctcag     2640

ggctgttcgc atgaaaatta ggccccttgt gacccaatag gctgaagaag tgggaatggg     2700

agcactctgt cttctttgct agagaagtgg agagaaaata caaaaggtaa agcagttgag     2760

attctctaca acctaaaaaa ttcctaggtg ctattttctt atcctttgta ctgtagctaa     2820

atgtacctga gacatattag tctttgaaaa ataaagttat gtaaggtttt ttttatcttt     2880

aaatagctct gtgggtttta acatttttat aaagatatac caagggccat tcagtacatc     2940

aggaaagtgg cagacagaag cttctctctg caaccttgaa gactattggt ttgagaactt     3000

ctcttcccat accacccaaa atcataatgc cattggaaag caaaaagttg ttttatccat     3060

ttgatttgaa ttgttttaag ccaatatttt aaggtaaaac tcactgaatc taaccatagc     3120

tgacctttgt agtagaattt acaacttata attacaatgc acaatttata attacaatat     3180

gtatttatgt cttttgctat ggagcaaatc caggaaggca agagaaacat tctttcctaa     3240

atataaatga aaatctatcc tttaaactct tccactagac gttgtaatgc acacttattt     3300

ttttcccaag gagtaaccaa tttctttcta aaacacattt aaaattttaa aactatttat     3360

gaatattaaa aaaagacata attcacacat taataaacaa tctcccaagt attgatttaa     3420

cttcattttt ctaataatca taaactatat tctgtgacat gctaattatt attaaatgta     3480

agtcgttagt tcgaaagcct ctcactaagt atgatctatg ctatattcaa aattcaaccc     3540

atttactttg gtcaatattt gatctaagtt gcatctttaa tcctggtggt cttgccttct     3600

gatttttaat ttgtatcctt ttctattaag atatatttgt cattttctct tgaatatgta     3660

ttaaaatatc ccaagcaaaa aaaaaaaaaa aa                                   3692


<210>  14
<211>  2181
<212>  DNA
<213>  Homo sapiens

<400>  14
aagtgacctt aaagccctag ctttgtggta gtgcacttaa attcagaatc acacttggta       60

actaataatg aaagatttca aaccccaaac agtgcaactg aaacttttgc attactatac      120

tactgagaat atctaacatg ttgttactaa tcaatgtcat tctgaccttg tgggtttcct      180

gtgctaatgg acaagaagtg aaaccttgtg attttccaga aattcaacat ggaggtctat      240

attataagag tttgcgtaga ctatactttc cagcagctgc aggacaatct tattcctatt      300

actgtgatca aaattttgtg actccttcag gaagttactg ggattacatt cattgcacac      360

aagatggttg gtcaccaacg gtcccatgcc tcagaacatg ctcaaaatca gatgtagaaa      420

ttgaaaatgg attcatttct gaatcttcct ctatttatat tttaaatgaa gaaacacaat      480

ataattgtaa accaggatat gcaacagcag agggaaattc ttcaggatca attacatgtt      540

tgcaaaatgg atggtcaaca caaccaattt gcattaaatt ttgtgatatg cctgtttttg      600

agaattccag agccaagagt aatggcatgt ggtttaagct ccatgacaca ttggactatg      660

aatgctatga tggatatgaa agcagttatg gaaacaccac agattccata gtgtgtggtg      720

aagatggctg gtcccatttg ccaacatgct ataattcttc agaaaactgt gggcctcctc      780

cacctattag caatggagat accacgtcct tcccgcaaaa agtgtatctg ccatggtcaa      840

gagtcgagta ccagtgccag tcctactatg aacttcaggg ttctaaatat gtaacatgta      900

gtaatggaga ctggtcagaa ccaccaagat gcatatcaat gaaaccttgt gagtttccag      960

aaattcaaca tggacatcta tattatgaga atacgcgtag accatacttt ccagtagcta     1020

caggacaatc ttactcctat tactgtgacc aaaattttgt gactccttca ggaagttact     1080

gggattacat tcactgcaca caagatgggt ggttgccaac agtcccatgc ctcagaacat     1140

gctcaaaatc agatatagaa attgaaaatg gattcatttc tgaatcttcc tctatttata     1200

ttttaaataa agaaatacaa tataaatgta aaccaggata tgcaacagca gatggaaatt     1260

cttcaggttc aattacatgt ttgcaaaatg gatggtcagc acaaccaatt tgcattaaat     1320

tttgtgatat gcctgttttt gagaattcca gagccaagag taatggcatg cggtttaagc     1380

tccatgacac attggactac gaatgctacg atggatatga aatcagttat ggaaacacca     1440

caggttccat agtgtgtggt gaagatgggt ggtcccattt cccaacatgt tataattctt     1500

cagaaaagtg tgggcctcct ccacctatta gcaatggtga taccacctcc tttctactaa     1560

aagtgtatgt gccacagtca agagtcgagt accaatgcca gtcctactat gaacttcagg     1620

gttctaatta tgtaacatgt agtaatggag agtggtcgga accaccaaga tgcatacatc     1680

catgtataat aactgaagaa aacatgaata aaaataacat acagttaaaa ggaaaaagtg     1740

acataaaata ttatgcaaaa acaggggata ccattgaatt tatgtgtaaa ttgggatata     1800

atgcgaatac atcagttcta tcatttcaag cagtgtgtag ggaaggcata gtggaatacc     1860

ccagatgcga ataaggcagc attgttaccc taaatgtatg tccaacttcc acttctcact     1920

cttatggtct caaagcttgc aaagatagct tctgatattg ttgtaatttc tactttattt     1980

caaagaaaat taatataata gtttcaattt gcaacttaat atgttctcaa aaatatgtta     2040

aaacaaacta aattattgct tatgcttgta ctaaaataat aaaaactacc cttatattgg     2100

acttcctatc aatgaattag taagtataga aacagataac tgaatggctt tctgcatatt     2160

gtacagtata cctagacata g                                               2181


<210>  15
<211>  1460
<212>  DNA
<213>  Homo sapiens

<400>  15
tgcagcgcag gtgagctctc ctgaggacct ctctgtcagc tcccctgatt gtagggagga       60

tccagtgtgg caagaaactc ctccagccca gcaagcagct caggatgttc ctgaaggccg      120

tggtcctgac cctggccctg gtggctgtcg ccggagccag ggctgaggtc agtgctgacc      180

aggtggccac ggtgatgtgg gactacttca gccagctgag caacaatgcc aaggaggccg      240

tggaacatct ccagaaatct gaactcaccc agcaactcaa tgccctcttc caggacaaac      300

ttggagaagt gaacacttac gcaggtgacc tgcagaagaa gctggtgccc tttgccaccg      360

agctgcatga acgcctggcc aaggactcgg agaaactgaa ggaggagatt gggaaggagc      420

tggaggagct gagggcccgg ctgctgcccc atgccaatga ggtgagccag aagatcgggg      480

acaacctgcg agagcttcag cagcgcctgg agccctacgc ggaccagctg cgcacccagg      540

tcagcacgca ggccgagcag ctgcggcgcc agctgacccc ctacgcacag cgcatggaga      600

gagtgctgcg ggagaacgcc gacagcctgc aggcctcgct gaggccccac gccgacgagc      660

tcaaggccaa gatcgaccag aacgtggagg agctcaaggg acgccttacg ccctacgctg      720

acgaattcaa agtcaagatt gaccagaccg tggaggagct gcgccgcagc ctggctccct      780

atgctcagga cacgcaggag aagctcaacc accagcttga gggcctgacc ttccagatga      840

agaagaacgc cgaggagctc aaggccagga tctcggccag tgccgaggag ctgcggcaga      900

ggctggcgcc cttggccgag gacgtgcgtg gcaacctgag gggcaacacc gaggggctgc      960

agaagtcact ggcagagctg ggtgggcacc tggaccagca ggtggaggag ttccgacgcc     1020

gggtggagcc ctacggggaa aacttcaaca aagccctggt gcagcagatg gaacagctca     1080

ggcagaaact gggcccccat gcgggggacg tggaaggcca cttgagcttc ctggagaagg     1140

acctgaggga caaggtcaac tccttcttca gcaccttcaa ggagaaagag agccaggaca     1200

agactctctc cctccctgag ctggagcaac agcaggaaca gcagcaggag cagcagcagg     1260

agcaggtgca gatgctggcc cctttggaga gctgagctgc ccctggtgca ctggccccac     1320

cctcgtggac acctgccctg ccctgccacc tgtctgtctg tctgtcccaa agaagttctg     1380

gtatgaactt gaggacacat gtccagtggg aggtgagacc acctctcaat attcaataaa     1440

gctgctgaga atctagcctc                                                 1460


<210>  16
<211>  8124
<212>  DNA
<213>  Homo sapiens

<400>  16
acgcccgcgc cggctgtgct gcacaggggg aggagaggga accccaggcg cgagcgggaa       60

gaggggacct gcagccacaa cttctctggt cctctgcatc ccttctgtcc ctccacccgt      120

ccccttcccc accctctggc ccccaccttc ttggaggcga caacccccgg gaggcattag      180

aagggatttt tcccgcaggt tgcgaaggga agcaaacttg gtggcaactt gcctcccggt      240

gcgggcgtct ctcccccacc gtctcaacat gcttaggggt ccggggcccg ggctgctgct      300

gctggccgtc cagtgcctgg ggacagcggt gccctccacg ggagcctcga agagcaagag      360

gcaggctcag caaatggttc agccccagtc cccggtggct gtcagtcaaa gcaagcccgg      420

ttgttatgac aatggaaaac actatcagat aaatcaacag tgggagcgga cctacctagg      480

caatgcgttg gtttgtactt gttatggagg aagccgaggt tttaactgcg agagtaaacc      540

tgaagctgaa gagacttgct ttgacaagta cactgggaac acttaccgag tgggtgacac      600

ttatgagcgt cctaaagact ccatgatctg ggactgtacc tgcatcgggg ctgggcgagg      660

gagaataagc tgtaccatcg caaaccgctg ccatgaaggg ggtcagtcct acaagattgg      720

tgacacctgg aggagaccac atgagactgg tggttacatg ttagagtgtg tgtgtcttgg      780

taatggaaaa ggagaatgga cctgcaagcc catagctgag aagtgttttg atcatgctgc      840

tgggacttcc tatgtggtcg gagaaacgtg ggagaagccc taccaaggct ggatgatggt      900

agattgtact tgcctgggag aaggcagcgg acgcatcact tgcacttcta gaaatagatg      960

caacgatcag gacacaagga catcctatag aattggagac acctggagca agaaggataa     1020

tcgaggaaac ctgctccagt gcatctgcac aggcaacggc cgaggagagt ggaagtgtga     1080

gaggcacacc tctgtgcaga ccacatcgag cggatctggc cccttcaccg atgttcgtgc     1140

agctgtttac caaccgcagc ctcaccccca gcctcctccc tatggccact gtgtcacaga     1200

cagtggtgtg gtctactctg tggggatgca gtggctgaag acacaaggaa ataagcaaat     1260

gctttgcacg tgcctgggca acggagtcag ctgccaagag acagctgtaa cccagactta     1320

cggtggcaac tcaaatggag agccatgtgt cttaccattc acctacaatg gcaggacgtt     1380

ctactcctgc accacagaag ggcgacagga cggacatctt tggtgcagca caacttcgaa     1440

ttatgagcag gaccagaaat actctttctg cacagaccac actgttttgg ttcagactcg     1500

aggaggaaat tccaatggtg ccttgtgcca cttccccttc ctatacaaca accacaatta     1560

cactgattgc acttctgagg gcagaagaga caacatgaag tggtgtggga ccacacagaa     1620

ctatgatgcc gaccagaagt ttgggttctg ccccatggct gcccacgagg aaatctgcac     1680

aaccaatgaa ggggtcatgt accgcattgg agatcagtgg gataagcagc atgacatggg     1740

tcacatgatg aggtgcacgt gtgttgggaa tggtcgtggg gaatggacat gcattgccta     1800

ctcgcagctt cgagatcagt gcattgttga tgacatcact tacaatgtga acgacacatt     1860

ccacaagcgt catgaagagg ggcacatgct gaactgtaca tgcttcggtc agggtcgggg     1920

caggtggaag tgtgatcccg tcgaccaatg ccaggattca gagactggga cgttttatca     1980

aattggagat tcatgggaga agtatgtgca tggtgtcaga taccagtgct actgctatgg     2040

ccgtggcatt ggggagtggc attgccaacc tttacagacc tatccaagct caagtggtcc     2100

tgtcgaagta tttatcactg agactccgag tcagcccaac tcccacccca tccagtggaa     2160

tgcaccacag ccatctcaca tttccaagta cattctcagg tggagaccta aaaattctgt     2220

aggccgttgg aaggaagcta ccataccagg ccacttaaac tcctacacca tcaaaggcct     2280

gaagcctggt gtggtatacg agggccagct catcagcatc cagcagtacg gccaccaaga     2340

agtgactcgc tttgacttca ccaccaccag caccagcaca cctgtgacca gcaacaccgt     2400

gacaggagag acgactccct tttctcctct tgtggccact tctgaatctg tgaccgaaat     2460

cacagccagt agctttgtgg tctcctgggt ctcagcttcc gacaccgtgt cgggattccg     2520

ggtggaatat gagctgagtg aggagggaga tgagccacag tacctggatc ttccaagcac     2580

agccacttct gtgaacatcc ctgacctgct tcctggccga aaatacattg taaatgtcta     2640

tcagatatct gaggatgggg agcagagttt gatcctgtct acttcacaaa caacagcgcc     2700

tgatgcccct cctgacccga ctgtggacca agttgatgac acctcaattg ttgttcgctg     2760

gagcagaccc caggctccca tcacagggta cagaatagtc tattcgccat cagtagaagg     2820

tagcagcaca gaactcaacc ttcctgaaac tgcaaactcc gtcaccctca gtgacttgca     2880

acctggtgtt cagtataaca tcactatcta tgctgtggaa gaaaatcaag aaagtacacc     2940

tgttgtcatt caacaagaaa ccactggcac cccacgctca gatacagtgc cctctcccag     3000

ggacctgcag tttgtggaag tgacagacgt gaaggtcacc atcatgtgga caccgcctga     3060

gagtgcagtg accggctacc gtgtggatgt gatccccgtc aacctgcctg gcgagcacgg     3120

gcagaggctg cccatcagca ggaacacctt tgcagaagtc accgggctgt cccctggggt     3180

cacctattac ttcaaagtct ttgcagtgag ccatgggagg gagagcaagc ctctgactgc     3240

tcaacagaca accaaactgg atgctcccac taacctccag tttgtcaatg aaactgattc     3300

tactgtcctg gtgagatgga ctccacctcg ggcccagata acaggatacc gactgaccgt     3360

gggccttacc cgaagaggac agcccaggca gtacaatgtg ggtccctctg tctccaagta     3420

cccactgagg aatctgcagc ctgcatctga gtacaccgta tccctcgtgg ccataaaggg     3480

caaccaagag agccccaaag ccactggagt ctttaccaca ctgcagcctg ggagctctat     3540

tccaccttac aacaccgagg tgactgagac caccattgtg atcacatgga cgcctgctcc     3600

aagaattggt tttaagctgg gtgtacgacc aagccaggga ggagaggcac cacgagaagt     3660

gacttcagac tcaggaagca tcgttgtgtc cggcttgact ccaggagtag aatacgtcta     3720

caccatccaa gtcctgagag atggacagga aagagatgcg ccaattgtaa acaaagtggt     3780

gacaccattg tctccaccaa caaacttgca tctggaggca aaccctgaca ctggagtgct     3840

cacagtctcc tgggagagga gcaccacccc agacattact ggttatagaa ttaccacaac     3900

ccctacaaac ggccagcagg gaaattcttt ggaagaagtg gtccatgctg atcagagctc     3960

ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa     4020

ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccagctgttc ctcctcccac     4080

tgacctgcga ttcaccaaca ttggtccaga caccatgcgt gtcacctggg ctccaccccc     4140

atccattgat ttaaccaact tcctggtgcg ttactcacct gtgaaaaatg aggaagatgt     4200

tgcagagttg tcaatttctc cttcagacaa tgcagtggtc ttaacaaatc tcctgcctgg     4260

tacagaatat gtagtgagtg tctccagtgt ctacgaacaa catgagagca cacctcttag     4320

aggaagacag aaaacaggtc ttgattcccc aactggcatt gacttttctg atattactgc     4380

caactctttt actgtgcact ggattgctcc tcgagccacc atcactggct acaggatccg     4440

ccatcatccc gagcacttca gtgggagacc tcgagaagat cgggtgcccc actctcggaa     4500

ttccatcacc ctcaccaacc tcactccagg cacagagtat gtggtcagca tcgttgctct     4560

taatggcaga gaggaaagtc ccttattgat tggccaacaa tcaacagttt ctgatgttcc     4620

gagggacctg gaagttgttg ctgcgacccc caccagccta ctgatcagct gggatgctcc     4680

tgctgtcaca gtgagatatt acaggatcac ttacggagag acaggaggaa atagccctgt     4740

ccaggagttc actgtgcctg ggagcaagtc tacagctacc atcagcggcc ttaaacctgg     4800

agttgattat accatcactg tgtatgctgt cactggccgt ggagacagcc ccgcaagcag     4860

caagccaatt tccattaatt accgaacaga aattgacaaa ccatcccaga tgcaagtgac     4920

cgatgttcag gacaacagca ttagtgtcaa gtggctgcct tcaagttccc ctgttactgg     4980

ttacagagta accaccactc ccaaaaatgg accaggacca acaaaaacta aaactgcagg     5040

tccagatcaa acagaaatga ctattgaagg cttgcagccc acagtggagt atgtggttag     5100

tgtctatgct cagaatccaa gcggagagag tcagcctctg gttcagactg cagtaaccac     5160

tattcctgca ccaactgacc tgaagttcac tcaggtcaca cccacaagcc tgagcgccca     5220

gtggacacca cccaatgttc agctcactgg atatcgagtg cgggtgaccc ccaaggagaa     5280

gaccggacca atgaaagaaa tcaaccttgc tcctgacagc tcatccgtgg ttgtatcagg     5340

acttatggtg gccaccaaat atgaagtgag tgtctatgct cttaaggaca ctttgacaag     5400

cagaccagct cagggagttg tcaccactct ggagaatgtc agcccaccaa gaagggctcg     5460

tgtgacagat gctactgaga ccaccatcac cattagctgg agaaccaaga ctgagacgat     5520

cactggcttc caagttgatg ccgttccagc caatggccag actccaatcc agagaaccat     5580

caagccagat gtcagaagct acaccatcac aggtttacaa ccaggcactg actacaagat     5640

ctacctgtac accttgaatg acaatgctcg gagctcccct gtggtcatcg acgcctccac     5700

tgccattgat gcaccatcca acctgcgttt cctggccacc acacccaatt ccttgctggt     5760

atcatggcag ccgccacgtg ccaggattac cggctacatc atcaagtatg agaagcctgg     5820

gtctcctccc agagaagtgg tccctcggcc ccgccctggt gtcacagagg ctactattac     5880

tggcctggaa ccgggaaccg aatatacaat ttatgtcatt gccctgaaga ataatcagaa     5940

gagcgagccc ctgattggaa ggaaaaagac agttcaaaag acccctttcg tcacccaccc     6000

tgggtatgac actggaaatg gtattcagct tcctggcact tctggtcagc aacccagtgt     6060

tgggcaacaa atgatctttg aggaacatgg ttttaggcgg accacaccgc ccacaacggc     6120

cacccccata aggcataggc caagaccata cccgccgaat gtaggacaag aagctctctc     6180

tcagacaacc atctcatggg ccccattcca ggacacttct gagtacatca tttcatgtca     6240

tcctgttggc actgatgaag aacccttaca gttcagggtt cctggaactt ctaccagtgc     6300

cactctgaca ggcctcacca gaggtgccac ctacaacatc atagtggagg cactgaaaga     6360

ccagcagagg cataaggttc gggaagaggt tgttaccgtg ggcaactctg tcaacgaagg     6420

cttgaaccaa cctacggatg actcgtgctt tgacccctac acagtttccc attatgccgt     6480

tggagatgag tgggaacgaa tgtctgaatc aggctttaaa ctgttgtgcc agtgcttagg     6540

ctttggaagt ggtcatttca gatgtgattc atctagatgg tgccatgaca atggtgtgaa     6600

ctacaagatt ggagagaagt gggaccgtca gggagaaaat ggccagatga tgagctgcac     6660

atgtcttggg aacggaaaag gagaattcaa gtgtgaccct catgaggcaa cgtgttatga     6720

tgatgggaag acataccacg taggagaaca gtggcagaag gaatatctcg gtgccatttg     6780

ctcctgcaca tgctttggag gccagcgggg ctggcgctgt gacaactgcc gcagacctgg     6840

gggtgaaccc agtcccgaag gcactactgg ccagtcctac aaccagtatt ctcagagata     6900

ccatcagaga acaaacacta atgttaattg cccaattgag tgcttcatgc ctttagatgt     6960

acaggctgac agagaagatt cccgagagta aatcatcttt ccaatccaga ggaacaagca     7020

tgtctctctg ccaagatcca tctaaactgg agtgatgtta gcagacccag cttagagttc     7080

ttctttcttt cttaagccct ttgctctgga ggaagttctc cagcttcagc tcaactcaca     7140

gcttctccaa gcatcaccct gggagtttcc tgagggtttt ctcataaatg agggctgcac     7200

attgcctgtt ctgcttcgaa gtattcaata ccgctcagta ttttaaatga agtgattcta     7260

agatttggtt tgggatcaat aggaaagcat atgcagccaa ccaagatgca aatgttttga     7320

aatgatatga ccaaaatttt aagtaggaaa gtcacccaaa cacttctgct ttcacttaag     7380

tgtctggccc gcaatactgt aggaacaagc atgatcttgt tactgtgata ttttaaatat     7440

ccacagtact cactttttcc aaatgatcct agtaattgcc tagaaatatc tttctcttac     7500

ctgttattta tcaatttttc ccagtatttt tatacggaaa aaattgtatt gaaaacactt     7560

agtatgcagt tgataagagg aatttggtat aattatggtg ggtgattatt ttttatactg     7620

tatgtgccaa agctttacta ctgtggaaag acaactgttt taataaaaga tttacattcc     7680

acaacttgaa gttcatctat ttgatataag acaccttcgg gggaaataat tcctgtgaat     7740

attctttttc aattcagcaa acatttgaaa atctatgatg tgcaagtcta attgttgatt     7800

tcagtacaag attttctaaa tcagttgcta caaaaactga ttggtttttg tcacttcatc     7860

tcttcactaa tggagatagc tttacacttt ctgctttaat agatttaagt ggaccccaat     7920

atttattaaa attgctagtt taccgttcag aagtataata gaaataatct ttagttgctc     7980

ttttctaacc attgtaattc ttcccttctt ccctccacct ttccttcatt gaataaacct     8040

ctgttcaaag agattgcctg caagggaaat aaaaatgact aagatattaa aagtatttga     8100

atagtaaaaa aaaaaaaaaa aaaa                                            8124


<210>  17
<211>  1307
<212>  DNA
<213>  Homo sapiens

<400>  17
acttatctgc agacttgtag gcagcaactc accctcactc agaggtcttc tggttctgga       60

aacaactcta gctcagcctt ctccaccatg agcctcagac ttgataccac cccttcctgt      120

aacagtgcga gaccacttca tgccttgcag gtgctgctgc ttctgtcatt gctgctgact      180

gctctggctt cctccaccaa aggacaaact aagagaaact tggcgaaagg caaagaggaa      240

agtctagaca gtgacttgta tgctgaactc cgctgcatgt gtataaagac aacctctgga      300

attcatccca aaaacatcca aagtttggaa gtgatcggga aaggaaccca ttgcaaccaa      360

gtcgaagtga tagccacact gaaggatggg aggaaaatct gcctggaccc agatgctccc      420

agaatcaaga aaattgtaca gaaaaaattg gcaggtgatg aatctgctga ttaatttgtt      480

ctgtttctgc caaacttctt taactcccag gaagggtaga attttgaaac cttgattttc      540

tagagttctc atttattcag gatacctatt cttactgtat taaaatttgg atatgtgttt      600

cattctgtct caaaaatcac attttattct gagaaggttg gttaaaagat ggcagaaaga      660

agatgaaaat aaataagcct ggtttcaacc ctctaattct tgcctaaaca ttggactgta      720

ctttgcattt ttttctttaa aaatttctat tctaacacaa cttggttgat ttttcctggt      780

ctactttatg gttattagac atactcatgg gtattattag atttcataat ggtcaatgat      840

aataggaatt acatggagcc caacagagaa tatttgctca atacattttt gttaatatat      900

ttaggaactt aatggagtct ctcagtgtct tagtcctagg atgtcttatt taaaatactc      960

cctgaaagtt tattctgatg tttattttag ccatcaaaca ctaaaataat aaattggtga     1020

atatgaatct tataaactgt ggttagctgg tttaaagtga atatatttgc cactagtaga     1080

acaaaaatag atgatgaaaa tgaattaaca tatctacata gttataattc tatcattaga     1140

atgagcctta taaataagta caatatagga cttcaacctt actagactcc taattctaaa     1200

ttctactttt ttcatcaaca gaactttcat tcatttttta aaccctaaaa cttataccca     1260

cactattctt acaaaaatat tcacatgaaa taaaaatttg ctattga                   1307


<210>  18
<211>  3863
<212>  DNA
<213>  Homo sapiens

<400>  18
atttaagagc caactgtctt gtctttcccg agtccgtttg aggaagtccc cgaggcgcac       60

agagcaagcc cacgcgaggg cacctctgga ggggagcgcc tgcaggacct tgtaaagtca      120

aaaatgtcag aaacttccag gaccgccttt ggaggcagaa gagcagttcc acccaataac      180

tctaatgcag cggaagatga cctgcccaca gtggagcttc agggcgtggt gccccggggc      240

gtcaacctgc aagagtttct taatgtcacg agcgttcacc tgttcaagga gagatgggac      300

actaacaagg tggaccacca cactgacaag tatgaaaaca acaagctgat tgtccgcaga      360

gggcagtctt tctatgtgca gattgacttc agtcgtccat atgaccccag aagggatctc      420

ttcagggtgg aatacgtcat tggtcgctac ccacaggaga acaagggaac ctacatccca      480

gtgcctatag tctcagagtt acaaagtgga aagtgggggg ccaagattgt catgagagag      540

gacaggtctg tgcggctgtc catccagtct tcccccaaat gtattgtggg gaaattccgc      600

atgtatgttg ctgtctggac tccctatggc gtacttcgaa ccagtcgaaa cccagaaaca      660

gacacgtaca ttctcttcaa tccttggtgt gaagatgatg ctgtgtatct ggacaatgag      720

aaagaaagag aagagtatgt cctgaatgac atcggggtaa ttttttatgg agaggtcaat      780

gacatcaaga ccagaagctg gagctatggt cagtttgaag atggcatcct ggacacttgc      840

ctgtatgtga tggacagagc acaaatggac ctctctggaa gagggaatcc catcaaagtc      900

agccgtgtgg ggtctgcaat ggtgaatgcc aaagatgacg aaggtgtcct cgttggatcc      960

tgggacaata tctatgccta tggcgtcccc ccatcggcct ggactggaag cgttgacatt     1020

ctattggaat accggagctc tgagaatcca gtccggtatg gccaatgctg ggtttttgct     1080

ggtgtcttta acacattttt acgatgcctt ggaataccag caagaattgt taccaattat     1140

ttctctgccc atgataatga tgccaatttg caaatggaca tcttcctgga agaagatggg     1200

aacgtgaatt ccaaactcac caaggattca gtgtggaact accactgctg gaatgaagca     1260

tggatgacaa ggcctgacct tcctgttgga tttggaggct ggcaagctgt ggacagcacc     1320

ccccaggaaa atagcgatgg catgtatcgg tgtggccccg cctcggttca agccatcaag     1380

cacggccatg tctgcttcca atttgatgca ccttttgttt ttgcagaggt caacagcgac     1440

ctcatttaca ttacagctaa gaaagatggc actcatgtgg tggaaaatgt ggatgccacc     1500

cacattggga aattaattgt gaccaaacaa attggaggag atggcatgat ggatattact     1560

gatacttaca aattccaaga aggtcaagaa gaagagagat tggccctaga aactgccctg     1620

atgtacggag ctaaaaagcc cctcaacaca gaaggtgtca tgaaatcaag gtccaacgtt     1680

gacatggact ttgaagtgga aaatgctgtg ctgggaaaag acttcaagct ctccatcacc     1740

ttccggaaca acagccacaa ccgttacacc atcacagctt atctctcagc caacatcacc     1800

ttctacaccg gggtcccgaa ggcagaattc aagaaggaga cgttcgacgt gacgctggag     1860

cccttgtcct tcaagaaaga ggcggtgctg atccaagccg gcgagtacat gggtcagctg     1920

ctggaacaag cgtccctgca cttctttgtc acagctcgca tcaatgagac cagggatgtt     1980

ctggccaagc aaaagtccac cgtgctaacc atccctgaga tcatcatcaa ggtccgtggc     2040

actcaggtag ttggttctga catgactgtg acagttgagt ttaccaatcc tttaaaagaa     2100

accctgcgaa atgtctgggt acacctggat ggtcctggag taacaagacc aatgaagaag     2160

atgttccgtg aaatccggcc caactccacc gtgcagtggg aagaagtgtg ccggccctgg     2220

gtctctgggc atcggaagct gatagccagc atgagcagtg actccctgag acatgtgtat     2280

ggcgagctgg acgtgcagat tcaaagacga ccttccatgt gaatgcacag gaagctgaga     2340

tgaaccctgg catttggcct cttgtagtct tggctaagga aattctaacg caaaaatagc     2400

tcttgctttg acttaggtgt gaagacccag acaggactgc agagggctcc agagtggaga     2460

tcccacatat ttcaaaaaca tgcttttcca aacccaggct attcggcaag gaagttagtt     2520

tttaatctct ccaccttcca aagagtgcta agcattagct ttaattaagc tctcatagct     2580

cataagagta acagtcatca tttatcatca caaatggcta catctccaaa tatcagtggg     2640

ctctcttacc agggagattt gctcaatacc tggcctcatt taaaacaaga cttcagattc     2700

cccactcagc cttttgggaa taatagcaca tgatttgggc tctagaattc cagtcccctt     2760

tctcggggtc aggttctacc ctccatgtga gaatattttt cccaggacta gagcacaaca     2820

taatttttat ttttggcaaa gccagaaaaa gatctttcat tttgcacctg cagccaagca     2880

aatgcctgcc aaattttaga tttaccttgt tagaagaggt ggccccatat taacaaattg     2940

catttgtggg aaacttaacc acctacaagg agataagaaa gcaggtgcaa cactcaagtc     3000

tattgaataa tgtagttttg tgatgcattt tatagaatgt gtcacactgt ggcctgatca     3060

gcaggagcca atatccctta ctttaaccct ttctgggatg caatactagg aagtaaagtg     3120

aagaatttat ctctttagtt agtgattata tttcacccat ctctcaggaa tcatctcctt     3180

tgcagaatga tgcaggttca ggtccccttt cagagatata ataagcccaa caagttgaag     3240

aagctggcgg atctagtgac cagatatata gaaggactgc agccactgat tctctcttgt     3300

ccttcacatc acccatgttg agacctcagc ttggcactca ggtgctgaag ggtaatatgg     3360

actcagcctt gcaaatagcc agtgctagtt ctgacccaac cacagaggat gctgacatca     3420

tttgtattat gttccaaggc tactacagag aaggctgcct gctatgtatt tgcaaggctg     3480

atttatggtc agaatttccc tctgatatgt ctagggtgtg atttaggtca gtagactgtg     3540

attcttagca aaaaatgaac agtgataagt atactggggg caaaatcaga atggaatgct     3600

ctggtctata taaccacatt tctaagcctt tgagactgtt cctgagcctt cagcactaac     3660

ctatgagggt gagctggtcc cctctatata tacatcatac ttaactttac taagtaatct     3720

cacagcattt gccaagtctc ccaatatcca attttaaaat gaaatgcatt ttgctagaca     3780

gttaaactgg cttaacttag tatattatta ttaattacaa tgtaatagaa gcttaaaata     3840

aagttaaact gattatattt gca                                             3863


<210>  19
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  19
aggctcacta taaatagcag ccacctctcc ctggcagaca gggacccgca gctcagctac       60

agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctgag      120

tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat      180

gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca      240

tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt      300

gatcagcaca atgaggcttt tcacaggcat tgttttctgc tccttggtca tgggagtcac      360

cagtgaaagc tggcgttcgt ttttcaagga ggctctccaa ggggttgggg acatgggcag      420

agcctattgg gacataatga tatccaatca ccaaaattca aacagatatc tctatgctcg      480

gggaaactat gatgctgccc aaagaggacc tgggggtgtc tgggctgcta aactcatcag      540

ccgttccagg gtctatcttc agggattaat agactgctat ttatttggaa acagcagcac      600

tgtattggag gactcgaagt ccaacgagaa agctgaggaa tggggccgga gtggcaaaga      660

ccccgaccgc ttcagacctg acggcctgcc taagaaatac tgagcttcct gctcctctgc      720

tctcagggaa actgggctgt gagccacaca cttctccccc cagacaggga cacagggtca      780

ctgagctttg tgtccccagg aactggtata gggcacctag aggtgttcaa taaatgtttg      840

tcaaattgaa                                                             850


<210>  20
<211>  622
<212>  DNA
<213>  Homo sapiens

<400>  20
gagttgagca cagagggaca gaggcacgga acccccagaa atgtccctcc tcagaaacag       60

gctccaggcc ctgcctgccc tgtgcctctg cgtgctggtc ctggcctgca ttggggcatg      120

ccagccagag gcccaggaag gaaccctgag ccccccacca aagctaaaga tgagtcgctg      180

gagcctggtg aggggcagga tgaaggagct gctggagaca gtggtgaaca ggaccagaga      240

cgggtggcaa tggttctgga gcccgagcac cttccggggc ttcatgcaga cctactatga      300

cgaccacctg agggacctgg gtccgctcac caaggcctgg ttcctcgaat ccaaagacag      360

cctcttgaag aagacccaca gcctgtgccc caggcttgtc tgtggggaca aggaccaggg      420

ttaaaatgtt cataaaagcc aggtgtggtt gtggcgggtg cctgtagtcc cagctactca      480

ggaggctgag gtaggatgat ggcttgagcc caggagttcg agaccagcct gggcaacaca      540

gcgagatctc ttgggggtaa aacaaaaaga aaaaaaaaag ttcatacttc tccaataaat      600

aaagtctcac ctgtgaaaaa aa                                               622


