                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  POLYPEPTIDE WITH TUMOUR BINDING ACTIVITY

<130>  789-20 PCT

<150>  EP17 158 242.2
<151>  2017-02-27

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is 0, 1, 2 or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(16)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is 0, 1, or 2 amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid, preferably selected from F, M, A, V, I, L, Y, 
       and W

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid, preferably an amino acid selected from T, Q, 
       S, and N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from F, W, T, G, A, I, L, 
       M, and V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  is any amino acid, preferably selected from M, A, I, L, V, and G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  is any amino acid, preferably selected from Q, D, R, and L

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  is 0, 1, 2, or 3 amino acids

<400>  1

Xaa Cys Xaa Xaa Xaa Xaa Arg Gly Asp Leu Xaa Xaa Leu Xaa Xaa Cys 
1               5                   10                  15      


Xaa 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(16)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from Q, D, R, and L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  is any amino acid, preferably selected from M, A, I, L, V, and G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  is any amino acid, preferably selected from F, W, T, G, A, I, L, 
       M, and V

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is any amino acid, preferably selected from T, Q, S, and N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid, preferably selected from F, M, A, V, I, L, Y, 
       and W

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is 0, 1, or 2 amino acids

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  is 0, 1, 2, or 3 amino acids

<400>  2

Xaa Cys Xaa Xaa Leu Xaa Xaa Leu Asp Gly Arg Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa 
    


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  3

Gly Arg Cys Thr Phe Arg Gly Asp Leu Met Gln Leu Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(14)

<400>  4

Asp Pro Tyr Cys Leu Gln Met Leu Asp Gly Arg Phe Thr Cys Gly Arg 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  5

Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg Leu Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(14)

<400>  6

Asp Pro Tyr Cys Leu Arg Gly Leu Asp Gly Arg Gly Thr Cys Gly Arg 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  7

Gly Arg Cys Thr Phe Arg Gly Asp Leu Met Gln Leu Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(14)

<400>  8

Asp Pro Tyr Cys Leu Gln Met Leu Asp Gly Arg Phe Thr Cys Gly Arg 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  9

Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg Leu Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(14)

<400>  10

Asp Pro Tyr Cys Leu Arg Gly Leu Asp Gly Arg Gly Thr Cys Gly Arg 
1               5                   10                  15      


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Phe Arg Gly Asp Leu Met Gln Leu 
1               5               


<210>  12
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (30)..(53)
<223>  n is a, c, g, or t

<400>  12
ttactcgctc catgggcggc aggtgtactn nnnnnnnnnn nnnnnnnnnn nnntgttatc       60

ccgat                                                                   65


<210>  13
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  13
ataatcttgc ggccgcaccg ccacctgctg catcgggata aca                         43


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  14

Trp Trp Lys Phe Met Trp Phe Gln 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  15

Phe Arg Gly Asp Lys Met Gln Leu 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  16

Arg Ala Trp Trp Ser His Trp His 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  17

His Trp Phe Trp Ser Lys Trp Trp 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  18

Trp Arg Trp Ala Ser Trp Phe Trp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  19

Trp His Gln Asn Ile His Ser Pro 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  20

Phe Asp Arg Gly Lys Met Gln Leu 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  21

Phe Arg Gly Asp Ala Met Gln Ala 
1               5               


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is o, 1, 2, or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(16)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is 0, 1, or 2 amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid, preferably selected from T, Q, S, and N, or 
       not present

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid, preferably selected from F, M, A, V, I, L, H, 
       Y, and W, or not present

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from F, W, T, G, A, I, L, 
       M, V, or not present

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  is any amino acid, preferably selected from M, A, I, L, V, and G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  is any amino acid, preferably selected from Q, D, R, and L

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  is 0, 1, 2, or 3 amino acids

<400>  22

Xaa Cys Xaa Xaa Xaa Xaa Arg Gly Asp Leu Xaa Xaa Leu Xaa Xaa Cys 
1               5                   10                  15      


Xaa 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(16)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from Q, D, R, and L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  is any amino acid, preferably selected from M, A, I, L, V, and G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  is any amino acid, preferably selected from F, W, T, G, A, I, L, 
       M, and V, or not present

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is any amino acid, preferably selected from F, M, A, V, I, L, H, 
       Y, and W, or not present

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid, preferably selected from T, Q, S, and N, or 
       not present

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is 0, 1, or 2 amino acids

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  0, 1, 2, or 3 amino acids

<400>  23

Xaa Cys Xaa Xaa Leu Xaa Xaa Leu Asp Gly Arg Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Xaa 
    


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(15)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is any amino acid, preferably selected from T and S, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid, preferably selected from F, H, Y, and W, or 
       not present

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid, preferably selected from F and G, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is any amino acid, preferably selected from M and G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  is any amino acid, preferably selected from Q and R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is  0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  is  0, 1, 2, or 3 amino acids

<400>  24

Xaa Cys Xaa Xaa Xaa Arg Gly Asp Leu Xaa Xaa Leu Xaa Xaa Cys Xaa 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  DISULFID
<222>  (2)..(15)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is any amino acid or not present

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from Q and R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  is any amino acid, preferably selected from  M and G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  is any amino acid, preferably selected from  F and G, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is any amino acid, preferably selected from  F, H, Y, and W, or 
       not present

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid, preferably selected from  T and S, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  is 0, 1, 2, or 3 amino acids

<400>  25

Xaa Cys Xaa Xaa Leu Xaa Xaa Leu Asp Gly Arg Xaa Xaa Xaa Cys Xaa 
1               5                   10                  15      


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(15)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid, preferably selected from F, H, Y, and W, or 
       not present

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid, preferably selected from F and G, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is 0, 1, 2, or 3 amino acids

<400>  26

Gly Arg Cys Thr Xaa Xaa Arg Gly Asp Leu Gly Arg Leu Xaa Cys Tyr 
1               5                   10                  15      


Pro Asp 
        


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(16)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is 0, 1, 2, or 3 amino acids

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is any amino acid, preferably selected from F and G, or not 
       present

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  is any amino acid, preferably selected from F, H, Y, and W, or 
       not present

<400>  27

Asp Pro Tyr Cys Xaa Leu Arg Gly Leu Asp Gly Arg Xaa Xaa Thr Cys 
1               5                   10                  15      


Arg Gly 
        


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  28

Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg Leu Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(14)

<400>  29

Asp Pro Tyr Cys Leu Arg Gly Leu Asp Gly Arg Gly Thr Cys Arg Gly 
1               5                   10                  15      


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(15)

<400>  30

Gly Arg Cys Thr His Gly Arg Gly Asp Leu Gly Arg Leu Lys Cys Tyr 
1               5                   10                  15      


Pro Asp 
        


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(16)

<400>  31

Asp Pro Tyr Cys Lys Leu Arg Gly Leu Asp Gly Arg Gly His Thr Cys 
1               5                   10                  15      


Arg Gly 
        


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(14)

<400>  32

Gly Arg Cys Thr His Gly Arg Gly Asp Leu Gly Arg Leu Cys Tyr Pro 
1               5                   10                  15      


Asp 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(15)

<400>  33

Asp Pro Tyr Cys Leu Arg Gly Leu Asp Gly Arg Gly His Thr Cys Arg 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(14)

<400>  34

Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg Leu Lys Cys Tyr Pro 
1               5                   10                  15      


Asp 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(15)

<400>  35

Asp Pro Tyr Cys Lys Leu Arg Gly Leu Asp Gly Arg Gly Thr Cys Arg 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(14)

<400>  36

Gly Arg Cys Thr Arg Gly Asp Leu Gly Arg Leu Lys Lys Cys Tyr Pro 
1               5                   10                  15      


Asp 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (4)..(15)

<400>  37

Asp Pro Tyr Cys Lys Lys Leu Arg Gly Leu Asp Gly Arg Thr Cys Arg 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DISULFID
<222>  (3)..(13)

<400>  38

Gly Arg Cys Thr Arg Gly Asp Leu Gly Arg Leu Lys Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  DNA_BIND
<222>  (4)..(14)

<400>  39

Asp Pro Tyr Cys Lys Leu Arg Gly Leu Asp Gly Arg Thr Cys Arg Gly 
1               5                   10                  15      


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  40

Gly Ser Gly Ser Lys 
1               5   


<210>  41
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  41

Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg Leu Cys Tyr Pro Asp 
1               5                   10                  15      


Gly Ser Gly Ser Lys Gly Arg Cys Thr Gly Arg Gly Asp Leu Gly Arg 
            20                  25                  30          


Leu Cys Tyr Pro Asp Gly Ser Gly Ser Lys Gly Arg Cys Thr Gly Arg 
        35                  40                  45              


Gly Asp Leu Gly Arg Leu Cys Tyr Pro Asp 
    50                  55              


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generalization of an integrin binding motive


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Arg Gly Asp Lys Xaa Xaa Leu 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generalization of an integrin binding motive


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Arg Gly Asp Leu Xaa Xaa Leu 
1               5           


