                         SEQUENCE LISTING

<110>  UNIVERSITE D'AIX MARSEILLE et al.
 
<120>  Radiolabeled soluble CD146, preparation and uses thereof.

<130>  B2444PC00

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu 
545                 550         


<210>  2
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro 
545                 550             


<210>  3
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu 
545                 550                 


<210>  4
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro 
545                 550                 555 


<210>  5
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu 
545                 550                 555     


<210>  6
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser 
545                 550                 555         


<210>  7
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Ala Trp Asn Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Asp Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Lys Leu Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg 
545                 550                 555             


<210>  8
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  8
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctg                               1656


<210>  9
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  9
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccg                            1659


<210>  10
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  10
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg ag                        1662


<210>  11
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  11
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccg                     1665


<210>  12
<211>  1668
<212>  DNA
<213>  Homo sapiens

<400>  12
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggag                  1668


<210>  13
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  13
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag c              1671


<210>  14
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  14
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag ccgg           1674


<210>  15
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro Ala 
1               5                   10                  15      


Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile Leu 
            20                  25                  30          


Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr Glu 
        35                  40                  45              


Lys Val Ala Arg Leu Gln Lys Val Glu Thr Glu Ile Gln Arg Val Ser 
    50                  55                  60                  


Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Lys Ala Met Arg Asn Lys Leu Leu Glu Gly Glu Ile Arg Arg Met 
                85                  90                  95      


His Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Thr Ala Asn Lys 
            100                 105                 110         


Gln Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Thr Arg Lys Thr 
        115                 120                 125             


Ile Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Lys Leu Glu Ala Glu Leu Ala Thr Ala Arg Ser Thr Asn Glu Asp Gln 
145                 150                 155                 160 


Arg Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala 
                165                 170                 175     


Lys Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val 
            180                 185                 190         


Asp Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala 
        195                 200                 205             


Cys Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Thr Arg Leu Glu 
    210                 215                 220                 


Glu Arg Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys 
225                 230                 235                 240 


Gln Pro Thr Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu 
                245                 250                 255     


Leu Arg Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr 
            260                 265                 270         


Lys Trp Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala 
        275                 280                 285             


Leu Asp Ala Ala Ala Thr Val Ala Ala Gln Arg Asp Thr Thr Val Ile 
    290                 295                 300                 


Ser His Ser Pro Asn Thr Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile 
305                 310                 315                 320 


Gln Lys Glu Glu Glu Glu Ile Leu Asn Ala Asn Lys Arg Cys Leu Asp 
                325                 330                 335     


Met Glu Gly Arg Ile Lys Thr Leu His Ala Gln Ile Ile Glu Lys Asp 
            340                 345                 350         


Ala Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys 
        355                 360                 365             


Thr Glu Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile 
    370                 375                 380                 


Ser Asn Ala Gly Ser Gly Leu Leu Ser His Ser Ser Thr Leu Thr Gly 
385                 390                 395                 400 


Ser Pro Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser 
                405                 410                 415     


Leu Gly Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser 
            420                 425                 430         


Thr Pro Ser Pro Val Pro Pro Ser Thr Pro Leu Leu Ser Ala His Ser 
        435                 440                 445             


Lys Thr Gly Ser Arg Asp Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu 
    450                 455                 460                 


Ser Asn Lys Thr Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Ala Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile 
                485                 490                 495     


Thr Thr Thr Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala 
            500                 505                 510         


Ala Pro Ala Ala Ala Ala Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr 
        515                 520                 525             


Ala Ala Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala 
    530                 535                 540                 


Ser Val Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala 
545                 550                 555                 560 


Ala Val Gln Val Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu 
                565                 570                 575     


Val Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln 
            580                 585                 590         


Thr Gln Pro Thr Ser Ala Pro Ala Val Ala Pro Thr Pro Ala Pro Thr 
        595                 600                 605             


Pro Thr Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Thr 
    610                 615                 620                 


Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Thr Cys Asn Pro 
625                 630                 635                 640 


Asp Lys Thr Asp Gly Pro Val Phe His Ser Asn Thr Leu Glu Arg Lys 
                645                 650                 655     


Thr Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu 
            660                 665                 670         


Tyr Leu Ile 
        675 


<210>  16
<211>  1084
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Asn Ser Glu Glu Gln Pro Ser Gly Gly Thr Thr Val Leu Gln 
1               5                   10                  15      


Arg Leu Leu Gln Glu Gln Leu Arg Tyr Gly Asn Pro Ser Glu Asn Arg 
            20                  25                  30          


Ser Leu Leu Ala Ile His Gln Gln Ala Thr Gly Asn Gly Pro Pro Phe 
        35                  40                  45              


Pro Ser Gly Ser Gly Asn Pro Gly Pro Gln Ser Asp Val Leu Ser Pro 
    50                  55                  60                  


Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro 
65                  70                  75                  80  


Gln Gly Gln Glu Ile Gln Ser Glu Asn Leu Ile Met Glu Lys Gln Leu 
                85                  90                  95      


Ser Pro Arg Met Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu Glu Ala 
            100                 105                 110         


Lys Val Gln Ser Gln Tyr Phe Arg Gly Gln Gln His Ala Ser Val Gly 
        115                 120                 125             


Ala Ala Phe Tyr Val Thr Gly Val Thr Asn Gln Lys Met Arg Thr Glu 
    130                 135                 140                 


Gly Arg Pro Ser Val Gln Arg Leu Asn Pro Gly Lys Met His Gln Asp 
145                 150                 155                 160 


Glu Gly Leu Arg Asp Leu Lys Gln Gly His Val Arg Ser Leu Ser Glu 
                165                 170                 175     


Arg Leu Met Gln Met Ser Leu Ala Thr Ser Gly Val Lys Ala His Pro 
            180                 185                 190         


Pro Val Thr Ser Ala Pro Leu Ser Pro Pro Gln Pro Asn Asp Leu Tyr 
        195                 200                 205             


Ala Asn Pro Thr Ser Ser Ser Glu Phe Tyr Lys Ala Gln Gly Pro Leu 
    210                 215                 220                 


Pro Asn Gln His Ser Leu Lys Gly Met Glu His Arg Gly Pro Pro Pro 
225                 230                 235                 240 


Glu Tyr Pro Phe Lys Gly Met Pro Pro Gln Ser Val Val Cys Lys Pro 
                245                 250                 255     


Gln Glu Pro Gly His Phe Tyr Ser Glu His Arg Leu Asn Gln Pro Gly 
            260                 265                 270         


Arg Thr Glu Gly Gln Leu Met Arg Tyr Gln His Pro Pro Glu Tyr Gly 
        275                 280                 285             


Ala Ala Arg Pro Ala Gln Asp Ile Ser Leu Pro Leu Ser Ala Arg Asn 
    290                 295                 300                 


Ser Gln Pro His Ser Pro Thr Ser Ser Leu Thr Ser Gly Gly Ser Leu 
305                 310                 315                 320 


Pro Leu Leu Gln Ser Pro Pro Ser Thr Arg Leu Ser Pro Ala Arg His 
                325                 330                 335     


Pro Leu Val Pro Asn Gln Gly Asp His Ser Ala His Leu Pro Arg Pro 
            340                 345                 350         


Gln Gln His Phe Leu Pro Asn Gln Ala His Gln Gly Asp His Tyr Arg 
        355                 360                 365             


Leu Ser Gln Pro Gly Leu Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    370                 375                 380                 


His His His His His His His Gln Gln Gln Gln Gln Gln Gln Pro Gln 
385                 390                 395                 400 


Gln Gln Pro Gly Glu Ala Tyr Ser Ala Met Pro Arg Ala Gln Pro Ser 
                405                 410                 415     


Ser Ala Ser Tyr Gln Pro Val Pro Ala Asp Pro Phe Ala Ile Val Ser 
            420                 425                 430         


Arg Ala Gln Gln Met Val Glu Ile Leu Ser Asp Glu Asn Arg Asn Leu 
        435                 440                 445             


Arg Gln Glu Leu Glu Gly Cys Tyr Glu Lys Val Ala Arg Leu Gln Lys 
    450                 455                 460                 


Val Glu Thr Glu Ile Gln Arg Val Ser Glu Ala Tyr Glu Asn Leu Val 
465                 470                 475                 480 


Lys Ser Ser Ser Lys Arg Glu Ala Leu Glu Lys Ala Met Arg Asn Lys 
                485                 490                 495     


Leu Leu Glu Gly Glu Ile Arg Arg Met His Asp Phe Asn Arg Asp Leu 
            500                 505                 510         


Arg Glu Arg Leu Glu Thr Ala Asn Lys Gln Leu Ala Glu Lys Glu Tyr 
        515                 520                 525             


Glu Gly Ser Glu Asp Thr Arg Lys Thr Ile Ser Gln Leu Phe Ala Lys 
    530                 535                 540                 


Asn Lys Glu Ser Gln Arg Glu Lys Glu Lys Leu Glu Ala Glu Leu Ala 
545                 550                 555                 560 


Thr Ala Arg Ser Thr Asn Glu Asp Gln Arg Arg His Ile Glu Ile Arg 
                565                 570                 575     


Asp Gln Ala Leu Ser Asn Ala Gln Ala Lys Val Val Lys Leu Glu Glu 
            580                 585                 590         


Glu Leu Lys Lys Lys Gln Val Tyr Val Asp Lys Val Glu Lys Met Gln 
        595                 600                 605             


Gln Ala Leu Val Gln Leu Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu 
    610                 615                 620                 


Glu His Arg Leu Arg Thr Arg Leu Glu Glu Arg Glu Leu Glu Ser Leu 
625                 630                 635                 640 


Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro Thr Asn Val Ser Glu 
                645                 650                 655     


Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg Glu Lys Glu Glu Arg 
            660                 665                 670         


Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu 
        675                 680                 685             


Glu Glu Asn Val Met Arg His Phe Ala Leu Asp Ala Ala Ala Thr Val 
    690                 695                 700                 


Ala Ala Gln Arg Asp Thr Thr Val Ile Ser His Ser Pro Asn Thr Ser 
705                 710                 715                 720 


Tyr Asp Thr Ala Leu Glu Ala Arg Ile Gln Lys Glu Glu Glu Glu Ile 
                725                 730                 735     


Leu Asn Ala Asn Lys Arg Cys Leu Asp Met Glu Gly Arg Ile Lys Thr 
            740                 745                 750         


Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu Gln 
        755                 760                 765             


Gln Arg Ser Arg Lys Glu Pro Ser Lys Thr Glu Gln Leu Ser Cys Met 
    770                 775                 780                 


Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn Ala Gly Ser Gly Leu 
785                 790                 795                 800 


Leu Ser His Ser Ser Thr Leu Thr Gly Ser Pro Ile Met Glu Glu Lys 
                805                 810                 815     


Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly Ile Leu Leu Gly Gly 
            820                 825                 830         


Asp Tyr Arg Ala Glu Tyr Val Pro Ser Thr Pro Ser Pro Val Pro Pro 
        835                 840                 845             


Ser Thr Pro Leu Leu Ser Ala His Ser Lys Thr Gly Ser Arg Asp Cys 
    850                 855                 860                 


Ser Thr Gln Thr Glu Arg Gly Thr Glu Ser Asn Lys Thr Ala Ala Val 
865                 870                 875                 880 


Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala Ala Ala Thr Ala Ala 
                885                 890                 895     


Ala Ile Thr Ala Thr Ala Ala Thr Ile Thr Thr Thr Met Val Ala Ala 
            900                 905                 910         


Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala 
        915                 920                 925             


Pro Ser Pro Ala Thr Ala Ala Ala Thr Ala Ala Ala Val Ser Pro Ala 
    930                 935                 940                 


Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val Ala Ser Ala Ala Ala 
945                 950                 955                 960 


Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val Gln Val Pro Ala Ala 
                965                 970                 975     


Pro Ala Pro Val Pro Ala Pro Ala Leu Val Pro Val Pro Ala Pro Ala 
            980                 985                 990         


Ala Ala Gln Ala Ser Ala Pro Ala  Gln Thr Gln Pro Thr  Ser Ala Pro 
        995                 1000                 1005             


Ala Val  Ala Pro Thr Pro Ala  Pro Thr Pro Thr Pro  Ala Val Ala 
    1010                 1015                 1020             


Gln Ala  Glu Val Pro Ala Ser  Pro Ala Thr Gly Pro  Gly Pro His 
    1025                 1030                 1035             


Arg Leu  Ser Ile Pro Ser Leu  Thr Cys Asn Pro Asp  Lys Thr Asp 
    1040                 1045                 1050             


Gly Pro  Val Phe His Ser Asn  Thr Leu Glu Arg Lys  Thr Pro Ile 
    1055                 1060                 1065             


Gln Ile  Leu Gly Gln Glu Pro  Asp Ala Glu Met Val  Glu Tyr Leu 
    1070                 1075                 1080             


Ile 
    


