                         SEQUENCE LISTING

<110>  ALPHA-O PEPTIDES
 
<120>  Self-assembling protein nanoparticles encapsulating 
       immunostimulatory nucleid acids

<130>  P5288EP00

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEDDLI-RR

<400>  1

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Arg Arg Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
385                 390                 


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag

<400>  2

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser 
            20          


<210>  3
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pentameric coiled coil

<400>  3

Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu Trp Glu Asn Asp Trp Asn 
1               5                   10                  15      


Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg Asp Asp Trp Ala Arg Trp 
            20                  25                  30          


Arg Ala Thr Trp 
        35      


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  4

Arg Arg Gly Arg 
1               


<210>  5
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimeric coiled coil

<400>  5

Leu Leu Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg 
1               5                   10                  15      


Arg Leu Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe 
            20                  25                  30          


Val Arg Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu 
        35                  40                  45              


Glu Leu 
    50  


<210>  6
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D0D1 of flagellin

<400>  6

Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
1               5                   10                  15      


Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile 
            20                  25                  30          


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
        35                  40                  45              


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu 
    50                  55                  60                  


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
65                  70                  75                  80  


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg 
                85                  90                  95      


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
            100                 105                 110         


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
        115                 120                 125             


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp 
    130                 135                 140                 


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
145                 150                 155                 160 


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
                165                 170                 175     


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
            180                 185                 190         


Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
        195                 200                 205             


Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
    210                 215                 220                 


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
225                 230                 235                 240 


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
                245                 250                 255     


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
            260                 265                 270         


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
        275                 280         


<210>  7
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trp-zipper

<400>  7

Ser Ser Asn Ala Lys Trp Asp Gln Trp Ser Ser Asp Trp Gln Thr Trp 
1               5                   10                  15      


Asn Ala Lys Trp Asp Gln Trp Ser Asn Asp Trp Asn Ala Trp Arg Ser 
            20                  25                  30          


Asp Trp Gln Ala Trp Lys Asp Asp Trp Ala Arg Trp Asn Gln Arg Trp 
        35                  40                  45              


Asp Asn Trp Ala Thr 
    50              


<210>  8
<211>  9
<212>  PRT
<213>  Influenza virus

<400>  8

Ile Arg His Glu Asn Arg Met Val Leu 
1               5                   


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker replacing D2 and D3 of flagellin

<400>  9

Asp Gly Asp Lys Gly Asp Asp Lys 
1               5               


<210>  10
<211>  180
<212>  PRT
<213>  Salmonella typhimurium

<400>  10

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu Asn Val Gln 
                165                 170                 175     


Gln Lys Tyr Lys 
            180 


<210>  11
<211>  91
<212>  PRT
<213>  Salmonella typhimurium

<400>  11

Thr Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp 
1               5                   10                  15      


Ala Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala 
            20                  25                  30          


Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser 
        35                  40                  45              


Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg 
    50                  55                  60                  


Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn 
65                  70                  75                  80  


Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                85                  90      


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  12

Lys Lys Gly Lys 
1               


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG ODN 1826


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  all phosphorothioates bonds

<400>  13
tccatgacgt tcctgacgtt                                                   20


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Arg Arg Gly Arg Arg Gly Arg 
1               5           


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Arg Arg Gly Arg Arg Gly Arg Arg Gly Arg 
1               5                   10  


<210>  16
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2RR

<400>  16

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Glu Glu Trp Glu Glu Trp Asn Ala Arg Trp 
            20                  25                  30          


Asp Glu Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala 
        35                  40                  45              


Trp Arg Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Arg Arg Gly Arg 
    50                  55                  60                  


Arg Gly Arg Leu Leu Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu 
65                  70                  75                  80  


Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg His Glu Asn Arg Met Val 
                85                  90                  95      


Leu Gln Phe Val Arg Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg 
            100                 105                 110         


Arg Leu Glu Glu Leu Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn 
        115                 120                 125             


Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala 
    130                 135                 140                 


Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser 
145                 150                 155                 160 


Ala Arg Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala 
                165                 170                 175     


Asn Ile Arg Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile 
            180                 185                 190         


Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn 
        195                 200                 205             


Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn 
    210                 215                 220                 


Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu 
225                 230                 235                 240 


Asn Glu Ile Asp Arg Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg 
                245                 250                 255     


Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp 
            260                 265                 270         


Gly Glu Thr Ile Asp Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu 
        275                 280                 285             


Gly Leu Asp Gln Leu Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys 
    290                 295                 300                 


Gly Asp Asp Lys Thr Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu 
305                 310                 315                 320 


Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg 
                325                 330                 335     


Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser 
            340                 345                 350         


Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser 
        355                 360                 365             


Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    370                 375                 380                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
385                 390                 395                 


<210>  17
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3RR

<400>  17

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Glu Glu Trp Glu Glu Trp Asn Ala Arg Trp 
            20                  25                  30          


Asp Glu Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala 
        35                  40                  45              


Trp Arg Asp Asp Trp Ala Arg Trp Asp Ala Thr Trp Arg Arg Gly Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly Arg Leu Leu Ser Arg Leu Glu Arg Leu Glu Arg 
65                  70                  75                  80  


Arg Asn Glu Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg His Glu Asn 
                85                  90                  95      


Arg Met Val Leu Gln Phe Val Arg Ala Leu Ser Met Gln Asn Ala Glu 
            100                 105                 110         


Leu Glu Arg Arg Leu Glu Glu Leu Ala Arg Gly Met Ala Gln Val Ile 
        115                 120                 125             


Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Arg Ser 
    130                 135                 140                 


Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg 
145                 150                 155                 160 


Ile Asn Ser Ala Arg Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg 
                165                 170                 175     


Phe Thr Ala Asn Ile Arg Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn 
            180                 185                 190         


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
        195                 200                 205             


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn 
    210                 215                 220                 


Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr 
225                 230                 235                 240 


Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Gln Thr Gln Phe Asn 
                245                 250                 255     


Gly Val Arg Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly 
            260                 265                 270         


Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Arg Gln Ile Asn Ser 
        275                 280                 285             


Gln Thr Leu Gly Leu Asp Gln Leu Asn Val Gln Gln Lys Tyr Lys Asp 
    290                 295                 300                 


Gly Asp Lys Gly Asp Asp Lys Thr Glu Asn Pro Leu Gln Arg Ile Asp 
305                 310                 315                 320 


Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala Val 
                325                 330                 335     


Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn 
            340                 345                 350         


Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr 
        355                 360                 365             


Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr 
    370                 375                 380                 


Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu 
385                 390                 395                 400 


Leu Arg 
        


<210>  18
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIVELI1-RR

<400>  18

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Arg Arg Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Lys Val Lys 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Lys Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Ala Ala Ala Ala Arg 
385                 390                 


<210>  19
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIVELI2-RR

<400>  19

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Arg Arg Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Lys Val Lys 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Lys Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Ala Ala Ala Ala Arg 
385                 390                 


<210>  20
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIVELI1

<400>  20

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Met Gly Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Lys Val Lys 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Lys Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Ala Ala Ala Ala Arg 
385                 390                 


<210>  21
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIVELI2

<400>  21

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Met Gly Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Lys Val Lys 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Lys Tyr Lys Asp Gly Asp Lys Gly Asp Asp Lys Thr 
    290                 295                 300                 


Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu Ala Gln Val Asp Ala 
305                 310                 315                 320 


Leu Lys Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile 
                325                 330                 335     


Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg 
            340                 345                 350         


Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala 
        355                 360                 365             


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
    370                 375                 380                 


Val Pro Gln Asn Val Ala Ala Ala Ala Arg 
385                 390                 


<210>  22
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC-RR

<400>  22

Met Gly His His His His His His His His His His Thr Phe Arg Gly 
1               5                   10                  15      


Asn Asn Gly His Asn Ser Ser Ser Ser Leu Tyr Asn Gly Ser Gln Phe 
            20                  25                  30          


Ile Glu Gln Leu Asn Asn Ser Phe Thr Ser Ala Phe Leu Glu Ser Gln 
        35                  40                  45              


Ser Met Asn Lys Ile Gly Asp Asp Leu Ala Glu Thr Ile Ser Asn Glu 
    50                  55                  60                  


Leu Val Ser Val Leu Gln Lys Asn Ser Pro Thr Phe Leu Glu Ser Ser 
65                  70                  75                  80  


Phe Asp Ile Lys Ser Glu Val Lys Lys His Ala Lys Ser Met Leu Lys 
                85                  90                  95      


Glu Leu Ile Lys Val Gly Leu Pro Ser Phe Glu Asn Leu Val Ala Glu 
            100                 105                 110         


Asn Val Lys Pro Pro Lys Val Asp Pro Ala Thr Tyr Gly Ile Ile Val 
        115                 120                 125             


Pro Val Leu Thr Ser Leu Phe Asn Lys Val Glu Thr Ala Val Gly Ala 
    130                 135                 140                 


Lys Val Ser Asp Glu Ile Trp Asn Tyr Asn Ser Pro Asp Val Ser Glu 
145                 150                 155                 160 


Ser Glu Glu Ser Leu Ser Asp Asp Phe Phe Asp Ala Ser Gly Ser Ala 
                165                 170                 175     


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Ser Gly Ser Trp 
            180                 185                 190         


Glu Arg Trp Asn Ala Lys Trp Asp Glu Trp Arg Asn Asp Gln Asn Asp 
        195                 200                 205             


Trp Arg Glu Asp Trp Gln Ala Trp Arg Asp Asp Trp Ala Tyr Trp Thr 
    210                 215                 220                 


Leu Thr Trp Arg Arg Gly Arg Leu Tyr Ser Arg Leu Ala Arg Ile Glu 
225                 230                 235                 240 


Arg Arg Val Glu Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg His Glu 
                245                 250                 255     


Asn Arg Met Val Leu Gln Phe Val Arg Ala Leu Ser Met Gln Ala Arg 
            260                 265                 270         


Arg Leu Glu Ala Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe 
        275                 280                 285             


Lys Glu Asp Ala Arg Gly Thr Phe Arg Gly Asn Asn Gly His Asn Ser 
    290                 295                 300                 


Ser Ser Ser Leu Tyr Asn Gly Ser Gln Phe Ile Glu Gln Leu Asn Asn 
305                 310                 315                 320 


Ser Phe Thr Ser Ala Phe Leu Glu Ser Gln Ser Met Asn Lys Ile Gly 
                325                 330                 335     


Asp Asp Leu Ala Glu Thr Ile Ser Asn Glu Leu Val Ser Val Leu Gln 
            340                 345                 350         


Lys Asn Ser Pro Thr Phe Leu Glu Ser Ser Phe Asp Ile Lys Ser Glu 
        355                 360                 365             


Val Lys Lys His Ala Lys Ser Met Leu Lys Glu Leu Ile Lys Val Gly 
    370                 375                 380                 


Leu Pro Ser Phe Glu Asn Leu Val Ala Glu Asn Val Lys Pro Pro Lys 
385                 390                 395                 400 


Val Asp Pro Ala Thr Tyr Gly Ile Ile Val Pro Val Leu Thr Ser Leu 
                405                 410                 415     


Phe Asn Lys Val Glu Thr Ala Val Gly Ala Lys Val Ser Asp Glu Ile 
            420                 425                 430         


Trp Asn Tyr Asn Ser Pro Asp Val Ser Glu Ser Glu Glu Ser Leu Ser 
        435                 440                 445             


Asp Asp Phe Phe Asp 
    450             


<210>  23
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC-RR-D0D1

<400>  23

Met Gly His His His His His His His His His His Thr Phe Arg Gly 
1               5                   10                  15      


Asn Asn Gly His Asn Ser Ser Ser Ser Leu Tyr Asn Gly Ser Gln Phe 
            20                  25                  30          


Ile Glu Gln Leu Asn Asn Ser Phe Thr Ser Ala Phe Leu Glu Ser Gln 
        35                  40                  45              


Ser Met Asn Lys Ile Gly Asp Asp Leu Ala Glu Thr Ile Ser Asn Glu 
    50                  55                  60                  


Leu Val Ser Val Leu Gln Lys Asn Ser Pro Thr Phe Leu Glu Ser Ser 
65                  70                  75                  80  


Phe Asp Ile Lys Ser Glu Val Lys Lys His Ala Lys Ser Met Leu Lys 
                85                  90                  95      


Glu Leu Ile Lys Val Gly Leu Pro Ser Phe Glu Asn Leu Val Ala Glu 
            100                 105                 110         


Asn Val Lys Pro Pro Lys Val Asp Pro Ala Thr Tyr Gly Ile Ile Val 
        115                 120                 125             


Pro Val Leu Thr Ser Leu Phe Asn Lys Val Glu Thr Ala Val Gly Ala 
    130                 135                 140                 


Lys Val Ser Asp Glu Ile Trp Asn Tyr Asn Ser Pro Asp Val Ser Glu 
145                 150                 155                 160 


Ser Glu Glu Ser Leu Ser Asp Asp Phe Phe Asp Ala Ser Gly Ser Ala 
                165                 170                 175     


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Ser Gly Ser Trp 
            180                 185                 190         


Glu Arg Trp Asn Ala Lys Trp Asp Glu Trp Arg Asn Asp Gln Asn Asp 
        195                 200                 205             


Trp Arg Glu Asp Trp Gln Ala Trp Arg Asp Asp Trp Ala Tyr Trp Thr 
    210                 215                 220                 


Leu Thr Trp Arg Arg Gly Arg Leu Tyr Ser Arg Leu Ala Arg Ile Glu 
225                 230                 235                 240 


Arg Arg Val Glu Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg His Glu 
                245                 250                 255     


Asn Arg Met Val Leu Gln Phe Val Arg Ala Leu Ser Met Gln Ala Arg 
            260                 265                 270         


Arg Leu Glu Arg Arg Leu Glu Glu Leu Ala Arg Gly Met Ala Gln Val 
        275                 280                 285             


Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Arg 
    290                 295                 300                 


Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu 
305                 310                 315                 320 


Arg Ile Asn Ser Ala Arg Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn 
                325                 330                 335     


Arg Phe Thr Ala Asn Ile Arg Gly Leu Thr Gln Ala Ser Arg Asn Ala 
            340                 345                 350         


Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
        355                 360                 365             


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala 
    370                 375                 380                 


Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile 
385                 390                 395                 400 


Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Gln Thr Gln Phe 
                405                 410                 415     


Asn Gly Val Arg Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val 
            420                 425                 430         


Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Arg Gln Ile Asn 
        435                 440                 445             


Ser Gln Thr Leu Gly Leu Asp Gln Leu Asn Val Gln Gln Lys Tyr Lys 
    450                 455                 460                 


Asp Gly Asp Lys Gly Asp Asp Lys Thr Glu Asn Pro Leu Gln Arg Ile 
465                 470                 475                 480 


Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala 
                485                 490                 495     


Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val 
            500                 505                 510         


Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala 
        515                 520                 525             


Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly 
    530                 535                 540                 


Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser 
545                 550                 555                 560 


Leu Leu Arg 
            


<210>  24
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  substituent

<400>  24

Met Gly His His His His His His His His His His Thr Phe Arg Gly 
1               5                   10                  15      


Asn Asn Gly His Asn Ser Ser Ser Ser Leu Tyr Asn Gly Ser Gln Phe 
            20                  25                  30          


Ile Glu Gln Leu Asn Asn Ser Phe Thr Ser Ala Phe Leu Glu Ser Gln 
        35                  40                  45              


Ser Met Asn Lys Ile Gly Asp Asp Leu Ala Glu Thr Ile Ser Asn Glu 
    50                  55                  60                  


Leu Val Ser Val Leu Gln Lys Asn Ser Pro Thr Phe Leu Glu Ser Ser 
65                  70                  75                  80  


Phe Asp Ile Lys Ser Glu Val Lys Lys His Ala Lys Ser Met Leu Lys 
                85                  90                  95      


Glu Leu Ile Lys Val Gly Leu Pro Ser Phe Glu Asn Leu Val Ala Glu 
            100                 105                 110         


Asn Val Lys Pro Pro Lys Val Asp Pro Ala Thr Tyr Gly Ile Ile Val 
        115                 120                 125             


Pro Val Leu Thr Ser Leu Phe Asn Lys Val Glu Thr Ala Val Gly Ala 
    130                 135                 140                 


Lys Val Ser Asp Glu Ile Trp Asn Tyr Asn Ser Pro Asp Val Ser Glu 
145                 150                 155                 160 


Ser Glu Glu Ser Leu Ser Asp Asp Phe Phe Asp Ala Ser Gly Ser Ala 
                165                 170                 175     


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Ser Gly Ser 
            180                 185                 190     


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligomerization domain

<400>  25

Trp Glu Arg Trp Asn Ala Lys Trp Asp Glu Trp Arg Asn Asp Gln Asn 
1               5                   10                  15      


Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg Asp Asp Trp Ala Tyr Trp 
            20                  25                  30          


Thr Leu Thr Trp 
        35      


<210>  26
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  oligomerization domain

<400>  26

Leu Tyr Ser Arg Leu Ala Arg Ile Glu Arg Arg Val Glu Glu Leu Arg 
1               5                   10                  15      


Arg Leu Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe 
            20                  25                  30          


Val Arg Ala Leu Ser Met Gln Ala Arg Arg Leu 
        35                  40              


<210>  27
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  substituent

<400>  27

Glu Ala Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Glu 
1               5                   10                  15      


Asp Ala Arg Gly Thr Phe Arg Gly Asn Asn Gly His Asn Ser Ser Ser 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Gln Phe Ile Glu Gln Leu Asn Asn Ser Phe 
        35                  40                  45              


Thr Ser Ala Phe Leu Glu Ser Gln Ser Met Asn Lys Ile Gly Asp Asp 
    50                  55                  60                  


Leu Ala Glu Thr Ile Ser Asn Glu Leu Val Ser Val Leu Gln Lys Asn 
65                  70                  75                  80  


Ser Pro Thr Phe Leu Glu Ser Ser Phe Asp Ile Lys Ser Glu Val Lys 
                85                  90                  95      


Lys His Ala Lys Ser Met Leu Lys Glu Leu Ile Lys Val Gly Leu Pro 
            100                 105                 110         


Ser Phe Glu Asn Leu Val Ala Glu Asn Val Lys Pro Pro Lys Val Asp 
        115                 120                 125             


Pro Ala Thr Tyr Gly Ile Ile Val Pro Val Leu Thr Ser Leu Phe Asn 
    130                 135                 140                 


Lys Val Glu Thr Ala Val Gly Ala Lys Val Ser Asp Glu Ile Trp Asn 
145                 150                 155                 160 


Tyr Asn Ser Pro Asp Val Ser Glu Ser Glu Glu Ser Leu Ser Asp Asp 
                165                 170                 175     


Phe Phe Asp 
            


<210>  28
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  substituent

<400>  28

Glu Arg Arg Leu Glu Glu Leu Ala Arg Gly Met Ala Gln Val Ile Asn 
1               5                   10                  15      


Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn Asn Leu Asn Arg Ser Gln 
            20                  25                  30          


Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu Ser Ser Gly Leu Arg Ile 
        35                  40                  45              


Asn Ser Ala Arg Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe 
    50                  55                  60                  


Thr Ala Asn Ile Arg Gly Leu Thr Gln Ala Ser Arg Asn Ala Asn Asp 
65                  70                  75                  80  


Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn 
                85                  90                  95      


Asn Asn Leu Gln Arg Val Arg Glu Leu Ala Val Gln Ser Ala Asn Ser 
            100                 105                 110         


Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile Gln Ala Glu Ile Thr Gln 
        115                 120                 125             


Arg Leu Asn Glu Ile Asp Arg Val Ser Gly Gln Thr Gln Phe Asn Gly 
    130                 135                 140                 


Val Arg Val Leu Ala Gln Asp Asn Thr Leu Thr Ile Gln Val Gly Ala 
145                 150                 155                 160 


Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu Arg Gln Ile Asn Ser Gln 
                165                 170                 175     


Thr Leu Gly Leu Asp Gln Leu Asn Val Gln Gln Lys Tyr Lys Asp Gly 
            180                 185                 190         


Asp Lys Gly Asp Asp Lys Thr Glu Asn Pro Leu Gln Arg Ile Asp Ala 
        195                 200                 205             


Ala Leu Ala Gln Val Asp Ala Leu Arg Ser Asp Leu Gly Ala Val Gln 
    210                 215                 220                 


Asn Arg Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn 
225                 230                 235                 240 


Leu Ser Glu Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu 
                245                 250                 255     


Val Ser Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser 
            260                 265                 270         


Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu 
        275                 280                 285             


Arg 
    


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag

<400>  29

His His His His His His His His His His 
1               5                   10  


<210>  30
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CelTOS

<400>  30

Thr Phe Arg Gly Asn Asn Gly His Asn Ser Ser Ser Ser Leu Tyr Asn 
1               5                   10                  15      


Gly Ser Gln Phe Ile Glu Gln Leu Asn Asn Ser Phe Thr Ser Ala Phe 
            20                  25                  30          


Leu Glu Ser Gln Ser Met Asn Lys Ile Gly Asp Asp Leu Ala Glu Thr 
        35                  40                  45              


Ile Ser Asn Glu Leu Val Ser Val Leu Gln Lys Asn Ser Pro Thr Phe 
    50                  55                  60                  


Leu Glu Ser Ser Phe Asp Ile Lys Ser Glu Val Lys Lys His Ala Lys 
65                  70                  75                  80  


Ser Met Leu Lys Glu Leu Ile Lys Val Gly Leu Pro Ser Phe Glu Asn 
                85                  90                  95      


Leu Val Ala Glu Asn Val Lys Pro Pro Lys Val Asp Pro Ala Thr Tyr 
            100                 105                 110         


Gly Ile Ile Val Pro Val Leu Thr Ser Leu Phe Asn Lys Val Glu Thr 
        115                 120                 125             


Ala Val Gly Ala Lys Val Ser Asp Glu Ile Trp Asn Tyr Asn Ser Pro 
    130                 135                 140                 


Asp Val Ser Glu Ser Glu Glu Ser Leu Ser Asp Asp Phe Phe Asp 
145                 150                 155                 


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PADRE

<400>  31

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  32
<211>  15
<212>  PRT
<213>  Lymphocytic choriomeningitis virus

<400>  32

Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Glu Asp 
1               5                   10                  15  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical segment

<400>  33

Glu Arg Arg Leu Glu Glu Leu 
1               5           


<210>  34
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RR-SSIEF

<400>  34

Met Gly Asp Lys His His His His His His His His His His Lys Asp 
1               5                   10                  15      


Gly Ser Asp Lys Gly Ser Trp Glu Glu Trp Asn Ala Arg Trp Asp Glu 
            20                  25                  30          


Trp Glu Asn Asp Trp Asn Asp Trp Arg Glu Asp Trp Gln Ala Trp Arg 
        35                  40                  45              


Asp Asp Trp Ala Arg Trp Arg Ala Thr Trp Arg Arg Gly Arg Leu Leu 
    50                  55                  60                  


Ser Arg Leu Glu Arg Leu Glu Arg Arg Asn Glu Glu Leu Arg Arg Leu 
65                  70                  75                  80  


Leu Gln Leu Ile Arg His Glu Asn Arg Met Val Leu Gln Phe Val Arg 
                85                  90                  95      


Ala Leu Ser Met Gln Asn Ala Glu Leu Glu Arg Arg Leu Glu Glu Leu 
            100                 105                 110         


Ala Arg Gly Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu 
        115                 120                 125             


Thr Gln Asn Asn Leu Asn Arg Ser Gln Ser Ala Leu Gly Thr Ala Ile 
    130                 135                 140                 


Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Arg Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Arg Gly Leu 
                165                 170                 175     


Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr 
            180                 185                 190         


Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg 
        195                 200                 205             


Glu Leu Ala Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu 
    210                 215                 220                 


Asp Ser Ile Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg 
225                 230                 235                 240 


Val Ser Gly Gln Thr Gln Phe Asn Gly Val Arg Val Leu Ala Gln Asp 
                245                 250                 255     


Asn Thr Leu Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp 
            260                 265                 270         


Ile Asp Leu Arg Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Gln Leu 
        275                 280                 285             


Asn Val Gln Gln Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala 
    290                 295                 300                 


Ala Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Asp Asp Thr Glu Asn 
305                 310                 315                 320 


Pro Leu Gln Arg Ile Asp Ala Ala Leu Ala Gln Val Asp Ala Leu Arg 
                325                 330                 335     


Ser Asp Leu Gly Ala Val Gln Asn Arg Phe Asn Ser Ala Ile Thr Asn 
            340                 345                 350         


Leu Gly Asn Thr Val Asn Asn Leu Ser Glu Ala Arg Ser Arg Ile Glu 
        355                 360                 365             


Asp Ser Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Arg Ala Gln Ile 
    370                 375                 380                 


Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro 
385                 390                 395                 400 


Gln Asn Val Leu Ser Leu Leu Arg 
                405             


<210>  35
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker replacing D2 and D3 of flagellin

<400>  35

Gln Leu Asn Val Gln Gln Ala Lys Phe Val Ala Ala Trp Thr Leu Lys 
1               5                   10                  15      


Ala Ala Ala Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Asp Asp Thr 
            20                  25                  30          


Glu Asn Pro Leu Gln 
        35          


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modification of pentamer

<400>  36

Arg Ala Thr Trp 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified sequence in Trp-zipper

<400>  37

Asn Gln Arg Trp 
1               


<210>  38
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pan DR binding CD4 epitope string

<400>  38

Glu Leu Arg Arg Leu Leu Gln Leu Ile Arg His Glu Asn Arg Met Val 
1               5                   10                  15      


Leu Gln Phe Val Arg Ala Leu Ser Met Gln Asn Ala 
            20                  25              


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG ODN1585


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate bond between residues 1 and 2,  between residues
       15 and 16, between residues 16 and 17, between residues 17 and 
       18, between residues 18 and 19, and between residues 19 and 20

<400>  39
ggggtcaacg ttgagggggg                                                   20


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alanines

<400>  40

Ala Ala Ala Ala 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Met Gly Gly Arg 
1               


<210>  42
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG ODN 2006 (ODN 7909)


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  all phosphorothioates bonds

<400>  42
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2216


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate bond between residues 1 and 2,  between residues
       15 and 16, between residues 16 and 17, between residues 17 and  
       18, between residues 18 and 19, and between residues 19 and 20

<400>  43
gggggacgat cgtcgggggg                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2336


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  phosphorothioate bond between residues 1 and 2, etween residues 2
       and 3, between residues 16 and 17, between residues 17 and 18, 
       between residues 18 and  19, between residues 19 and 20, and 
       between residues 20 and 21

<400>  44
ggggacgacg tcgtgggggg g                                                 21


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN BW006


<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  all phosphorothioates bonds

<400>  45
tcgacgttcg tcgttcgtcg ttc                                               23


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2395


<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  all phosphorothioates bonds

<400>  46
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  47
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN M362


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  all phosphorothioates bonds

<400>  47
tcgtcgtcgt tcgaacgacg ttgat                                             25


<210>  48
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN D-SL03


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  all phosphorothioates bonds

<400>  48
tcgcgaacgt tcgccgcgtt cgaacgcgg                                         29


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN D-SL01


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  all phosphorothioates bonds

<400>  49
tcgcgacgtt cgcccgacgt tcggta                                            26


