                         SEQUENCE LISTING

<110>  Philogen
 
<120>  Immunoconjugates with optimized linkers and orientation

<130>  PD 43137

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VL-CDR1

<400>  1

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VL-CDR2

<400>  2

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VL-CDR3

<400>  3

Gln Gln Ala Ile Gly Phe Pro Gln Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VH-CDR1

<400>  4

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VH-CDR2

<400>  5

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C11 VH-CDR3

<400>  6

Thr Leu Ala Ala Phe Asp Tyr 
1               5           


<210>  7
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  C11-VL

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Ile Gly Phe Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  8
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  C11-VH

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gln Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  70
<212>  PRT
<213>  Homo sapiens IGF-1

<400>  9

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  AKKAS linker

<400>  10

Gly Gly Gly Ala Lys Gly Gly Gly Gly Lys Ala Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  DDS linker

<400>  11

Gly Gly Gly Gly Asp Gly Gly Gly Gly Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  SAD linker

<400>  12

Gly Ser Ala Asp Gly Gly Ser Ser Ala Gly Gly Ser Asp Ala Gly 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  SES linker

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  (G4S)3 linker

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11-VH-AKKAS-variant

<400>  15

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Ala Lys Gly Gly Gly Gly Lys 
65                  70                  75                  80  


Ala Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        195                 200     


<210>  16
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11-VH-DDS-variant

<400>  16

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Gly Asp Gly Gly Gly Gly Asp 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        195                 200     


<210>  17
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11-VH-SAD-variant

<400>  17

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Ser Ala Asp Gly Gly Ser Ser Ala Gly 
65                  70                  75                  80  


Gly Ser Asp Ala Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        195                 200     


<210>  18
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11-VH-SES-variant

<400>  18

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        195                 200     


<210>  19
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  IGF-1-C11-VH-(G4S)3-variant

<400>  19

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        195                 200     


<210>  20
<211>  555
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11(scFV-Fc)-(G4S)3-variant

<400>  20

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    210                 215                 220                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
225                 230                 235                 240 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                245                 250                 255     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            260                 265                 270         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        275                 280                 285             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    290                 295                 300                 


Gln Gln Ala Ile Gly Phe Pro Gln Thr Phe Gly Gln Gly Thr Lys Val 
305                 310                 315                 320 


Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                325                 330                 335     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            340                 345                 350         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        355                 360                 365             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    370                 375                 380                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
385                 390                 395                 400 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                405                 410                 415     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            420                 425                 430         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        435                 440                 445             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    450                 455                 460                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
465                 470                 475                 480 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                485                 490                 495     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            500                 505                 510         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        515                 520                 525             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    530                 535                 540                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555 


<210>  21
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  IGF1-C11(SIP)-(G4S)3-variant

<400>  21

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Gln Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Lys Thr Leu Ala Ala Phe Asp Tyr Trp Gly 
            180                 185                 190         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    210                 215                 220                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
225                 230                 235                 240 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                245                 250                 255     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            260                 265                 270         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        275                 280                 285             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    290                 295                 300                 


Gln Gln Ala Ile Gly Phe Pro Gln Thr Phe Gly Gln Gly Thr Lys Val 
305                 310                 315                 320 


Glu Ile Lys Ser Gly Gly Ser Gly Gly Pro Arg Ala Ala Pro Glu Val 
                325                 330                 335     


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
            340                 345                 350         


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
        355                 360                 365             


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
    370                 375                 380                 


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
385                 390                 395                 400 


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
                405                 410                 415     


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
            420                 425                 430         


Ser Val Asn Pro Glu Ser Ser Arg Arg Gly Gly Cys 
        435                 440                 


