                         SEQUENCE LISTING

<110>  Evox Therapeutics
 
<120>  Improved loading of EVs with therapeutic proteins

<130>  Evox9

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly Phe 
1               5                   10                  15      


Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly Leu 
            20                  25                  30          


Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu Thr 
        35                  40                  45              


Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly 
    50                  55                  60                  


Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala 
65                  70                  75                  80  


Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu 
                85                  90                  95      


Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser His 
            100                 105                 110         


Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr 
        115                 120                 125             


Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala 
    130                 135                 140                 


Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln 
145                 150                 155                 160 


Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr 
                165                 170                 175     


Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe 
            180                 185                 190         


His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe 
        195                 200                 205             


Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg 
    210                 215                 220                 


Glu Met Val 
225         


<210>  2
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 


<210>  3
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val Leu 
1               5                   10                  15      


Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly Val 
            20                  25                  30          


Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr Pro 
        35                  40                  45              


Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu Phe 
    50                  55                  60                  


Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys 
65                  70                  75                  80  


Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val Glu 
                85                  90                  95      


Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met Ser 
            100                 105                 110         


Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn 
        115                 120                 125             


Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys Cys 
    130                 135                 140                 


Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met Ser 
145                 150                 155                 160 


Lys Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
                165                 170                 175     


Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
            180                 185                 190         


Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
        195                 200                 205             


Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
    210                 215                 220                 


Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
225                 230                 235         


<210>  4
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  5
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  6
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  7
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe 
1               5                   10                  15      


Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu 
            20                  25                  30          


Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu 
        35                  40                  45              


Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser 
    50                  55                  60                  


Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met 
65                  70                  75                  80  


Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile 
                85                  90                  95      


Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met 
            100                 105                 110         


Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser 
        115                 120                 125             


Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile 
    130                 135                 140                 


Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr 
145                 150                 155                 160 


Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala 
                165                 170                 175     


Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala 
            180                 185                 190         


Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu 
        195                 200                 205             


Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu 
225                 230                 235                 240 


Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val 
                245                 250                 255     


Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile 
            260                 265                 270         


Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu 
        275                 280                 285             


Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln 
    290                 295                 300                 


Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly 
305                 310                 315                 320 


Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu 
                325                 330                 335     


Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala 
            340                 345                 350         


Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile 
        355                 360                 365             


Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly 
    370                 375                 380                 


Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile 
385                 390                 395                 400 


Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile 
                405                 410                 415     


Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala 
            420                 425         


<210>  8
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Asn Cys His Thr Val Gly Pro Asn Glu Ala Leu Val Val Ser Gly 
1               5                   10                  15      


Gly Cys Cys Gly Ser Asp Tyr Lys Gln Tyr Val Phe Gly Gly Trp Ala 
            20                  25                  30          


Trp Ala Trp Trp Cys Ile Ser Asp Thr Gln Arg Ile Ser Leu Glu Ile 
        35                  40                  45              


Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly Val 
    50                  55                  60                  


Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu Lys 
65                  70                  75                  80  


Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val Gln 
                85                  90                  95      


Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg Ser 
            100                 105                 110         


Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp Gln 
        115                 120                 125             


Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg Met 
    130                 135                 140                 


Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys Val 
145                 150                 155                 160 


Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln Arg 
                165                 170                 175     


Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile Arg 
            180                 185                 190         


Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala Asp 
        195                 200                 205             


Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser Ala 
    210                 215                 220                 


Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala Tyr 
225                 230                 235                 240 


Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu Ile 
                245                 250                 255     


Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala Gln 
            260                 265                 270         


Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg Pro 
        275                 280                 285             


Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu Lys 
    290                 295                 300                 


Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg Lys 
305                 310                 315                 320 


Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala Glu 
                325                 330                 335     


Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly Asp 
            340                 345                 350         


Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala Ala 
        355                 360                 365             


Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu Ser 
    370                 375                 380                 


Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys Ile 
                405                 410                 415     


Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
            420                 425         


<210>  9
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  10
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  11
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15      


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30          


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45              


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60                  


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80  


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95      


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110         


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125             


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140                 


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160 


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175     


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190         


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205             


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220                 


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240 


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255     


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270         


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285             


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300                 


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320 


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335     


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350         


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365             


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380                 


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400 


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415     


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430         


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445             


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460                 


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480 


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495     


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510         


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525             


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540                 


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560 


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575     


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590         


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605             


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620                 


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640 


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655     


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670         


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685             


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700                 


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720 


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735     


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750         


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765             


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780                 


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800 


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815     


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830         


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845             


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860                 


His 
865 


<210>  12
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Leu Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  13
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  14
<211>  867
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Thr Phe Ile Ser Val Gln Leu Lys Lys Thr Ser Glu Val Asp Leu 
1               5                   10                  15      


Ala Lys Pro Leu Val Lys Phe Ile Gln Gln Thr Tyr Pro Ser Gly Gly 
            20                  25                  30          


Glu Glu Gln Ala Gln Tyr Cys Arg Ala Ala Glu Glu Leu Ser Lys Leu 
        35                  40                  45              


Arg Arg Ala Ala Val Gly Arg Pro Leu Asp Lys His Glu Gly Ala Leu 
    50                  55                  60                  


Glu Thr Leu Leu Arg Tyr Tyr Asp Gln Ile Cys Ser Ile Glu Pro Lys 
65                  70                  75                  80  


Phe Pro Phe Ser Glu Asn Gln Ile Cys Leu Thr Phe Thr Trp Lys Asp 
                85                  90                  95      


Ala Phe Asp Lys Gly Ser Leu Phe Gly Gly Ser Val Lys Leu Ala Leu 
            100                 105                 110         


Ala Ser Leu Gly Tyr Glu Lys Ser Cys Val Leu Phe Asn Cys Ala Ala 
        115                 120                 125             


Leu Ala Ser Gln Ile Ala Ala Glu Gln Asn Leu Asp Asn Asp Glu Gly 
    130                 135                 140                 


Leu Lys Ile Ala Ala Lys His Tyr Gln Phe Ala Ser Gly Ala Phe Leu 
145                 150                 155                 160 


His Ile Lys Glu Thr Val Leu Ser Ala Leu Ser Arg Glu Pro Thr Val 
                165                 170                 175     


Asp Ile Ser Pro Asp Thr Val Gly Thr Leu Ser Leu Ile Met Leu Ala 
            180                 185                 190         


Gln Ala Gln Glu Val Phe Phe Leu Lys Ala Thr Arg Asp Lys Met Lys 
        195                 200                 205             


Asp Ala Ile Ile Ala Lys Leu Ala Asn Gln Ala Ala Asp Tyr Phe Gly 
    210                 215                 220                 


Asp Ala Phe Lys Gln Cys Gln Tyr Lys Asp Thr Leu Pro Lys Glu Val 
225                 230                 235                 240 


Phe Pro Val Leu Ala Ala Lys His Cys Ile Met Gln Ala Asn Ala Glu 
                245                 250                 255     


Tyr His Gln Ser Ile Leu Ala Lys Gln Gln Lys Lys Phe Gly Glu Glu 
            260                 265                 270         


Ile Ala Arg Leu Gln His Ala Ala Glu Leu Ile Lys Thr Val Ala Ser 
        275                 280                 285             


Arg Tyr Asp Glu Tyr Val Asn Val Lys Asp Phe Ser Asp Lys Ile Asn 
    290                 295                 300                 


Arg Ala Leu Ala Ala Ala Lys Lys Asp Asn Asp Phe Ile Tyr His Asp 
305                 310                 315                 320 


Arg Val Pro Asp Leu Lys Asp Leu Asp Pro Ile Gly Lys Ala Thr Leu 
                325                 330                 335     


Val Lys Ser Thr Pro Val Asn Val Pro Ile Ser Gln Lys Phe Thr Asp 
            340                 345                 350         


Leu Phe Glu Lys Met Val Pro Val Ser Val Gln Gln Ser Leu Ala Ala 
        355                 360                 365             


Tyr Asn Gln Arg Lys Ala Asp Leu Val Asn Arg Ser Ile Ala Gln Met 
    370                 375                 380                 


Arg Glu Ala Thr Thr Leu Ala Asn Gly Val Leu Ala Ser Leu Asn Leu 
385                 390                 395                 400 


Pro Ala Ala Ile Glu Asp Val Ser Gly Asp Thr Val Pro Gln Ser Ile 
                405                 410                 415     


Leu Thr Lys Ser Arg Ser Val Ile Glu Gln Gly Gly Ile Gln Thr Val 
            420                 425                 430         


Asp Gln Leu Ile Lys Glu Leu Pro Glu Leu Leu Gln Arg Asn Arg Glu 
        435                 440                 445             


Ile Leu Asp Glu Ser Leu Arg Leu Leu Asp Glu Glu Glu Ala Thr Asp 
    450                 455                 460                 


Asn Asp Leu Arg Ala Lys Phe Lys Glu Arg Trp Gln Arg Thr Pro Ser 
465                 470                 475                 480 


Asn Glu Leu Tyr Lys Pro Leu Arg Ala Glu Gly Thr Asn Phe Arg Thr 
                485                 490                 495     


Val Leu Asp Lys Ala Val Gln Ala Asp Gly Gln Val Lys Glu Cys Tyr 
            500                 505                 510         


Gln Ser His Arg Asp Thr Ile Val Leu Leu Cys Lys Pro Glu Pro Glu 
        515                 520                 525             


Leu Asn Ala Ala Ile Pro Ser Ala Asn Pro Ala Lys Thr Met Gln Gly 
    530                 535                 540                 


Ser Glu Val Val Asn Val Leu Lys Ser Leu Leu Ser Asn Leu Asp Glu 
545                 550                 555                 560 


Val Lys Lys Glu Arg Glu Gly Leu Glu Asn Asp Leu Lys Ser Val Asn 
                565                 570                 575     


Phe Asp Met Thr Ser Lys Phe Leu Thr Ala Leu Ala Gln Asp Gly Val 
            580                 585                 590         


Ile Asn Glu Glu Ala Leu Ser Val Thr Glu Leu Asp Arg Val Tyr Gly 
        595                 600                 605             


Gly Leu Thr Thr Lys Val Gln Glu Ser Leu Lys Lys Gln Glu Gly Leu 
    610                 615                 620                 


Leu Lys Asn Ile Gln Val Ser His Gln Glu Phe Ser Lys Met Lys Gln 
625                 630                 635                 640 


Ser Asn Asn Glu Ala Asn Leu Arg Glu Glu Val Leu Lys Asn Leu Ala 
                645                 650                 655     


Thr Ala Tyr Asp Asn Phe Val Glu Leu Val Ala Asn Leu Lys Glu Gly 
            660                 665                 670         


Thr Lys Phe Tyr Asn Glu Leu Thr Glu Ile Leu Val Arg Phe Gln Asn 
        675                 680                 685             


Lys Cys Ser Asp Ile Val Phe Ala Arg Lys Thr Glu Arg Asp Glu Leu 
    690                 695                 700                 


Leu Lys Asp Leu Gln Gln Ser Ile Ala Arg Glu Pro Ser Ala Pro Ser 
705                 710                 715                 720 


Ile Pro Thr Pro Ala Tyr Gln Ser Ser Pro Ala Gly Gly His Ala Pro 
                725                 730                 735     


Thr Pro Pro Thr Pro Ala Pro Arg Thr Met Pro Pro Thr Lys Pro Gln 
            740                 745                 750         


Pro Pro Ala Arg Pro Pro Pro Pro Val Leu Pro Ala Asn Arg Ala Pro 
        755                 760                 765             


Ser Ala Thr Ala Pro Ser Pro Val Gly Ala Gly Thr Ala Ala Pro Ala 
    770                 775                 780                 


Pro Ser Gln Thr Pro Gly Ser Ala Pro Pro Pro Gln Ala Gln Gly Pro 
785                 790                 795                 800 


Pro Tyr Pro Thr Tyr Pro Gly Tyr Pro Gly Tyr Cys Gln Met Pro Met 
                805                 810                 815     


Pro Met Gly Tyr Asn Pro Tyr Ala Tyr Gly Gln Tyr Asn Met Pro Tyr 
            820                 825                 830         


Pro Pro Val Tyr His Gln Ser Pro Gly Gln Ala Pro Tyr Pro Gly Pro 
        835                 840                 845             


Gln Gln Pro Ser Tyr Pro Phe Pro Gln Pro Pro Gln Gln Ser Tyr Tyr 
    850                 855                 860                 


Pro Gln Gln 
865         


<210>  15
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile Gln 
1               5                   10                  15      


Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu Ser 
            20                  25                  30          


Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg Leu 
        35                  40                  45              


Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu Glu 
    50                  55                  60                  


Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly Gln 
65                  70                  75                  80  


Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val Thr 
                85                  90                  95      


Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile Arg 
            100                 105                 110         


Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg Leu 
        115                 120                 125             


Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn Ser 
    130                 135                 140                 


Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln Ile 
145                 150                 155                 160 


Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys Val 
                165                 170                 175     


Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp Arg 
            180                 185                 190         


Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His Val 
        195                 200                 205             


Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp Ser 
    210                 215                 220                 


Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu Ile 
225                 230                 235                 240 


Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp Ile 
                245                 250                 255     


Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala Phe 
            260                 265                 270         


Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys Ser 
        275                 280                 285             


Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295         


<210>  16
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Gln Ala 
1               5                   10                  15      


Ile Gln Ala Gln Val Arg Ala Ser Pro Lys Met Pro Ala Leu Pro Val 
            20                  25                  30          


Gln Ala Thr Ala Ile Ser Pro Pro Pro Val Leu Tyr Pro Asn Leu Ala 
        35                  40                  45              


Glu Leu Glu Asn Tyr Met Gly Leu Ser Leu Ser Ser Gln Glu Val Gln 
    50                  55                  60                  


Glu Ser Leu Leu Gln Ile Pro Glu Gly Asp Ser Thr Ala Val Ser Gly 
65                  70                  75                  80  


Pro Gly Pro Gly Gln Met Val Ala Pro Val Thr Gly Tyr Ser Leu Gly 
                85                  90                  95      


Val Arg Arg Ala Glu Ile Lys Pro Gly Val Arg Glu Ile His Leu Cys 
            100                 105                 110         


Lys Asp Glu Arg Gly Lys Thr Gly Leu Arg Leu Arg Lys Val Asp Gln 
        115                 120                 125             


Gly Leu Phe Val Gln Leu Val Gln Ala Asn Thr Pro Ala Ser Leu Val 
    130                 135                 140                 


Gly Leu Arg Phe Gly Asp Gln Leu Leu Gln Ile Asp Gly Arg Asp Cys 
145                 150                 155                 160 


Ala Gly Trp Ser Ser His Lys Ala His Gln Val Val Lys Lys Ala Ser 
                165                 170                 175     


Gly Asp Lys Ile Val Val Val Val Arg Asp Arg Pro Phe Gln Arg Thr 
            180                 185                 190         


Val Thr Met His Lys Asp Ser Met Gly His Val Gly Phe Val Ile Lys 
        195                 200                 205             


Lys Gly Lys Ile Val Ser Leu Val Lys Gly Ser Ser Ala Ala Arg Asn 
    210                 215                 220                 


Gly Leu Leu Thr Asn His Tyr Val Cys Glu Val Asp Gly Gln Asn Val 
225                 230                 235                 240 


Ile Gly Leu Lys Asp Lys Lys Ile Met Glu Ile Leu Ala Thr Ala Gly 
                245                 250                 255     


Asn Val Val Thr Leu Thr Ile Ile Pro Ser Val Ile Tyr Glu His Met 
            260                 265                 270         


Val Lys Lys Leu Pro Pro Val Leu Leu His His Thr Met Asp His Ser 
        275                 280                 285             


Ile Pro Asp Ala 
    290         


<210>  17
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  18
<211>  33
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210>  19
<211>  38
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Cys Gly Gly Arg Glu Gly Val Leu Lys Lys Leu Arg Ala Val Glu Asn 
1               5                   10                  15      


Glu Leu His Tyr Asn Lys Ser Leu Leu Glu Glu Val Lys Asp Glu Leu 
            20                  25                  30          


Gln Lys Met Arg Gln Leu 
        35              


<210>  20
<211>  30
<212>  PRT
<213>  Bacteriophage T4

<400>  20

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Phe Leu Ser Thr Phe Leu Ser Pro Ala 
            20                  25                  30  


<210>  21
<211>  60
<212>  PRT
<213>  respiratory syncytial virus

<400>  21

Glu Thr Ile Glu Thr Phe Asp Asn Asn Glu Glu Glu Ser Ser Tyr Ser 
1               5                   10                  15      


Tyr Glu Glu Ile Asn Asp Gln Thr Asn Asp Asn Ile Thr Ala Arg Leu 
            20                  25                  30          


Asp Arg Ile Asp Glu Lys Leu Ser Glu Ile Leu Gly Met Leu His Thr 
        35                  40                  45              


Leu Val Val Ala Ser Ala Gly Pro Thr Ser Ala Arg 
    50                  55                  60  


<210>  22
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu Val 
1               5                   10                  15      


Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe Ile 
            20                  25                  30          


Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile Pro 
        35                  40                  45              


Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60              


<210>  23
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  23

Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala 
1               5                   10                  15      


Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu 
            20                  25                  


<210>  24
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  24

Phe Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile 
1               5                   10                  15      


Ile Val Met Leu Leu 
            20      


<210>  25
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  26
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
1               5                   10                  15      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            20                  25                  30          


Gly Ile Arg Arg Leu Ile Lys Lys 
        35                  40  


<210>  27
<211>  60
<212>  PRT
<213>  Human immunodeficiency virus

<400>  27

Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Arg Leu Leu Ser 
1               5                   10                  15      


Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
            20                  25                  30          


Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
        35                  40                  45              


Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
    50                  55                  60  


<210>  28
<211>  56
<212>  PRT
<213>  Human papillomavirus type 45

<400>  28

Gly Ser His Met Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
1               5                   10                  15      


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
            20                  25                  30          


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
        35                  40                  45              


Cys Pro Trp Cys Ala Thr Asn Gln 
    50                  55      


<210>  29
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Lys Val Ser Lys 
1               5                   10                  15      


Gln Glu Glu Ala Ser Gly Gly Pro Thr Ala Pro Lys Ala Glu Ser Gly 
            20                  25                  30          


Arg Ser Gly Gly Gly Gly Leu Met Glu Glu Met Asn Ala Met Leu Ala 
        35                  40                  45              


Arg Arg Arg Lys Ala Thr Gln Val Gly Glu Lys Thr Pro Lys Asp Glu 
    50                  55                  60                  


Ser Ala Asn Gln Glu Glu Pro Glu Ala Arg Val Pro Ala Gln Ser Glu 
65                  70                  75                  80  


Ser Val Arg Arg Pro Trp Glu Lys Asn Ser Thr Thr Leu Pro Arg Met 
                85                  90                  95      


Lys Ser Ser Ser Ser Val Thr Thr Ser Glu Thr Gln Pro Cys Thr Pro 
            100                 105                 110         


Ser Ser Ser Asp Tyr Ser Asp Leu Gln Arg Val Lys Gln Glu Leu Leu 
        115                 120                 125             


Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile Glu 
    130                 135                 140                 


Ala Phe Val Gln Glu Leu Arg Lys Arg 
145                 150             


<210>  30
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Val Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  31
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  32
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  33
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  34
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  35
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Pro Trp Leu Gln Leu Cys Ser Val Phe Phe Thr Val Asn Ala 
1               5                   10                  15      


Cys Leu Asn Gly Ser Gln Leu Ala Val Ala Ala Gly Gly Ser Gly Arg 
            20                  25                  30          


Ala Arg Gly Ala Asp Thr Cys Gly Trp Arg Gly Val Gly Pro Ala Ser 
        35                  40                  45              


Arg Asn Ser Gly Leu Tyr Asn Ile Thr Phe Lys Tyr Asp Asn Cys Thr 
    50                  55                  60                  


Thr Tyr Leu Asn Pro Val Gly Lys His Val Ile Ala Asp Ala Gln Asn 
65                  70                  75                  80  


Ile Thr Ile Ser Gln Tyr Ala Cys His Asp Gln Val Ala Val Thr Ile 
                85                  90                  95      


Leu Trp Ser Pro Gly Ala Leu Gly Ile Glu Phe Leu Lys Gly Phe Arg 
            100                 105                 110         


Val Ile Leu Glu Glu Leu Lys Ser Glu Gly Arg Gln Cys Gln Gln Leu 
        115                 120                 125             


Ile Leu Lys Asp Pro Lys Gln Leu Asn Ser Ser Phe Lys Arg Thr Gly 
    130                 135                 140                 


Met Glu Ser Gln Pro Phe Leu Asn Met Lys Phe Glu Thr Asp Tyr Phe 
145                 150                 155                 160 


Val Lys Val Val Pro Phe Pro Ser Ile Lys Asn Glu Ser Asn Tyr His 
                165                 170                 175     


Pro Phe Phe Phe Arg Thr Arg Ala Cys Asp Leu Leu Leu Gln Pro Asp 
            180                 185                 190         


Asn Leu Ala Cys Lys Pro Phe Trp Lys Pro Arg Asn Leu Asn Ile Ser 
        195                 200                 205             


Gln His Gly Ser Asp Met Gln Val Ser Phe Asp His Ala Pro His Asn 
    210                 215                 220                 


Phe Gly Phe Arg Phe Phe Tyr Leu His Tyr Lys Leu Lys His Glu Gly 
225                 230                 235                 240 


Pro Phe Lys Arg Lys Thr Cys Lys Gln Glu Gln Thr Thr Glu Thr Thr 
                245                 250                 255     


Ser Cys Leu Leu Gln Asn Val Ser Pro Gly Asp Tyr Ile Ile Glu Leu 
            260                 265                 270         


Val Asp Asp Thr Asn Thr Thr Arg Lys Val Met His Tyr Ala Leu Lys 
        275                 280                 285             


Pro Val His Ser Pro Trp Ala Gly Pro Ile Arg Ala Val Ala Ile Thr 
    290                 295                 300                 


Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr Leu Phe Thr Val Met 
305                 310                 315                 320 


Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
                325                 330                 335     


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
            340                 345                 350         


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
        355                 360                 365             


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
    370                 375                 380                 


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
385                 390                 395                 400 


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
                405                 410                 415     


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
            420                 425                 430         


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
        435                 440                 445             


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
    450                 455                 460                 


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
465                 470                 475                 480 


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
                485                 490                 495     


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
            500                 505                 510         


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
        515                 520                 525             


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
    530                 535                 540                 


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
545                 550                 555                 560 


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
                565                 570                 575     


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
            580                 585                 590         


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
        595                 600                 605             


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
    610                 615                 620                 


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
625                 630                 635                 640 


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
                645                 650                 655     


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
            660                 665                 670         


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
        675                 680                 685             


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
    690                 695                 700                 


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
705                 710                 715                 720 


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
                725                 730                 735     


Ala Pro Leu 
            


<210>  36
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     


Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             


Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 


Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 


Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     


Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         


<210>  37
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  38
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  39
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  40
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  41
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  42
<211>  11
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  42

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  43
<211>  511
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  43

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  44
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Asp Val Glu Trp Val Asp Val Ser Ser Leu Glu Trp Asp Leu Pro 
1               5                   10                  15      


Cys 
    


<210>  45
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Ile Thr Trp Asp Gln Leu Trp Asp Leu Met Lys 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Human immunodeficiency virus

<400>  46

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  47
<211>  222
<212>  PRT
<213>  Haemophilus influenzae

<400>  47

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser 
            20                  25                  30          


Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile 
        35                  40                  45              


Thr Asn Lys Val Asn Thr Val Ile Glu Lys Met Asn Ile Gln Phe Thr 
    50                  55                  60                  


Ala Val Gly Lys Glu Phe Asn Lys Leu Glu Lys Arg Met Glu Asn Leu 
65                  70                  75                  80  


Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala 
                85                  90                  95      


Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            100                 105                 110         


Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn 
        115                 120                 125             


Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    130                 135                 140                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro 
145                 150                 155                 160 


Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Val Asp Gly Val 
                165                 170                 175     


Lys Leu Glu Ser Met Gly Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr 
            180                 185                 190         


Val Ala Ser Ser Leu Val Leu Leu Val Ser Leu Gly Ala Ile Ser Phe 
        195                 200                 205             


Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
    210                 215                 220         


<210>  48
<211>  338
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  48

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Gly Thr Glu Asp Ser Gly Thr Thr Val Leu 
        195                 200                 205             


Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu Leu Phe 
    210                 215                 220                 


Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys Gly Thr Gly Tyr Ile 
225                 230                 235                 240 


Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu 
                245                 250                 255     


Trp Val Phe Leu Ser Thr Phe Leu Ser Pro Ala Asn Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Arg Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys 
        275                 280                 285             


Val Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala 
    290                 295                 300                 


Ile Leu Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr 
305                 310                 315                 320 


Pro Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Glu 
                325                 330                 335     


Gly Gly 
        


<210>  49
<211>  833
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  49

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Arg Met Lys Gln Leu Glu Asp 
        675                 680                 685             


Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val 
    690                 695                 700                 


Ala Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Ser Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp 
                725                 730                 735     


Lys Val Ile Gln Ala Gln Thr Ala Tyr Ser Ala Asn Pro Ala Ser Gln 
            740                 745                 750         


Ala Phe Val Leu Val Asp Ala Ser Ala Ala Leu Pro Pro Asp Gly Asn 
        755                 760                 765             


Leu Tyr Pro Lys Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser 
    770                 775                 780                 


Leu Asn Glu Ala Glu Ile Cys Glu Ser Met Pro Met Val Ser Gly Ala 
785                 790                 795                 800 


Pro Ala Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Val Asn Tyr Met 
                805                 810                 815     


Val Ala Pro Val Thr Gly Asn Asp Ala Gly Ile Arg Arg Ala Glu Ile 
            820                 825                 830         


Lys 
    


<210>  50
<211>  859
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  50

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Glu Thr Ile Glu Thr Phe Asp Asn 
        675                 680                 685             


Asn Glu Glu Glu Ser Ser Tyr Ser Tyr Glu Glu Ile Asn Asp Gln Thr 
    690                 695                 700                 


Asn Asp Asn Ile Thr Ala Arg Leu Asp Arg Ile Asp Glu Lys Leu Ser 
705                 710                 715                 720 


Glu Ile Leu Gly Met Leu His Thr Leu Val Val Ala Ser Ala Gly Pro 
                725                 730                 735     


Thr Ser Ala Arg Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu 
            740                 745                 750         


Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile Gln Ala Gln 
        755                 760                 765             


Thr Ala Tyr Ser Ala Asn Pro Ala Ser Gln Ala Phe Val Leu Val Asp 
    770                 775                 780                 


Ala Ser Ala Ala Leu Pro Pro Asp Gly Asn Leu Tyr Pro Lys Leu Tyr 
785                 790                 795                 800 


Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Ala Glu Ile 
                805                 810                 815     


Cys Glu Ser Met Pro Met Val Ser Gly Ala Pro Ala Gln Gly Gln Leu 
            820                 825                 830         


Val Ala Arg Pro Ser Ser Val Asn Tyr Met Val Ala Pro Val Thr Gly 
        835                 840                 845             


Asn Asp Ala Gly Ile Arg Arg Ala Glu Ile Lys 
    850                 855                 


<210>  51
<211>  782
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  51

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Arg Met Lys Gln Leu Glu Asp Lys 
        675                 680                 685             


Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
    690                 695                 700                 


Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Ser Gly Ser Gly Ser Gly 
705                 710                 715                 720 


Ser Gly Ser Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly 
                725                 730                 735     


Gly Glu Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp 
            740                 745                 750         


Gly Asp Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu 
        755                 760                 765             


Asn Ala Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys 
    770                 775                 780         


<210>  52
<211>  886
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  52

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Cys Asp Val Glu Trp Val Asp Val Ser Ser 
            20                  25                  30          


Leu Glu Trp Asp Leu Pro Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val 
    50                  55                  60                  


Val Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys 
65                  70                  75                  80  


Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr 
                85                  90                  95      


Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr 
            100                 105                 110         


Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu 
        115                 120                 125             


Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly 
    130                 135                 140                 


Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser 
145                 150                 155                 160 


Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly 
                165                 170                 175     


Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala 
            180                 185                 190         


Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser 
        195                 200                 205             


Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp 
    210                 215                 220                 


Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn 
225                 230                 235                 240 


Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser 
                245                 250                 255     


Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr 
            260                 265                 270         


Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr 
        275                 280                 285             


Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr 
    290                 295                 300                 


Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr 
305                 310                 315                 320 


Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr 
                325                 330                 335     


Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg 
            340                 345                 350         


Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr 
        355                 360                 365             


Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe 
    370                 375                 380                 


Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp 
385                 390                 395                 400 


Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val 
                405                 410                 415     


Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu 
            420                 425                 430         


Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe 
        435                 440                 445             


Gln Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn 
    450                 455                 460                 


Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr 
465                 470                 475                 480 


Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp 
                485                 490                 495     


Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn 
            500                 505                 510         


Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala 
        515                 520                 525             


Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala 
    530                 535                 540                 


Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn 
545                 550                 555                 560 


Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly 
                565                 570                 575     


Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu 
            580                 585                 590         


Thr Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser 
        595                 600                 605             


Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp 
    610                 615                 620                 


Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe 
625                 630                 635                 640 


Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe 
                645                 650                 655     


Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp 
            660                 665                 670         


Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro Ser Lys Ser 
        675                 680                 685             


His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His Asn Phe Asn 
    690                 695                 700                 


Ser Lys Asp Glu Thr Ile Glu Thr Phe Asp Asn Asn Glu Glu Glu Ser 
705                 710                 715                 720 


Ser Tyr Ser Tyr Glu Glu Ile Asn Asp Gln Thr Asn Asp Asn Ile Thr 
                725                 730                 735     


Ala Arg Leu Asp Arg Ile Asp Glu Lys Leu Ser Glu Ile Leu Gly Met 
            740                 745                 750         


Leu His Thr Leu Val Val Ala Ser Ala Gly Pro Thr Ser Ala Arg Gly 
        755                 760                 765             


Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu 
    770                 775                 780                 


Asp Leu Lys Val Asp Lys Val Ile Gln Ala Gln Thr Ala Tyr Ser Ala 
785                 790                 795                 800 


Asn Pro Ala Ser Gln Ala Phe Val Leu Val Asp Ala Ser Ala Ala Leu 
                805                 810                 815     


Pro Pro Asp Gly Asn Leu Tyr Pro Lys Leu Tyr Pro Glu Leu Ser Gln 
            820                 825                 830         


Tyr Met Gly Leu Ser Leu Asn Glu Ala Glu Ile Cys Glu Ser Met Pro 
        835                 840                 845             


Met Val Ser Gly Ala Pro Ala Gln Gly Gln Leu Val Ala Arg Pro Ser 
    850                 855                 860                 


Ser Val Asn Tyr Met Val Ala Pro Val Thr Gly Asn Asp Ala Gly Ile 
865                 870                 875                 880 


Arg Arg Ala Glu Ile Lys 
                885     


<210>  53
<211>  847
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  53

Met Glu Thr Ile Glu Thr Phe Asp Asn Asn Glu Glu Glu Ser Ser Tyr 
1               5                   10                  15      


Ser Tyr Glu Glu Ile Asn Asp Gln Thr Asn Asp Asn Ile Thr Ala Arg 
            20                  25                  30          


Leu Asp Arg Ile Asp Glu Lys Leu Ser Glu Ile Leu Gly Met Leu His 
        35                  40                  45              


Thr Leu Val Val Ala Ser Ala Gly Pro Thr Ser Ala Arg Met Asp Gln 
    50                  55                  60                  


Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu Pro Leu Ser Tyr 
65                  70                  75                  80  


Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp Asn Ser His Val 
                85                  90                  95      


Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala Asp Asn Asn Thr 
            100                 105                 110         


Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly Ser Ile Cys Tyr 
        115                 120                 125             


Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly Phe Met Ile Gly 
    130                 135                 140                 


Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr Glu Cys Glu Gly 
145                 150                 155                 160 


Leu Ala Gly Thr Glu Ser Pro Gly Gly Glu Glu Pro Gly Glu Asp Phe 
                165                 170                 175     


Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys Arg Lys Leu Ser 
            180                 185                 190         


Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile Lys Leu Leu Asn 
        195                 200                 205             


Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln Lys Asp Glu Asn 
    210                 215                 220                 


Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe Lys Leu Ser Lys 
225                 230                 235                 240 


Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val Lys Asp Ser Ala 
                245                 250                 255     


Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg Leu Val Tyr Leu 
            260                 265                 270         


Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys Ala Ala Thr Val 
        275                 280                 285             


Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys Lys Asp Phe Glu 
    290                 295                 300                 


Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile Val Arg Ala Gly 
305                 310                 315                 320 


Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu Ser Leu Asn Ala 
                325                 330                 335     


Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe Pro Ile Val Asn 
            340                 345                 350         


Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly Thr Gly Asp Pro 
        355                 360                 365             


Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln Phe Pro Pro Ser 
    370                 375                 380                 


Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr Ile Ser Arg Ala 
385                 390                 395                 400 


Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp Cys Pro Ser Asp 
                405                 410                 415     


Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser Glu Ser Lys Asn 
            420                 425                 430         


Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile Lys Ile Leu Asn 
        435                 440                 445             


Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp His Tyr Val Val 
    450                 455                 460                 


Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Gly 
465                 470                 475                 480 


Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met Phe Ser Asp Met 
                485                 490                 495     


Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile Ile Phe Ala Ser 
            500                 505                 510         


Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr Glu Trp Leu Glu 
        515                 520                 525             


Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr Tyr Ile Asn Leu 
    530                 535                 540                 


Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val Ser Ala Ser Pro 
545                 550                 555                 560 


Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn Val Lys His Pro 
                565                 570                 575     


Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp Ala Ser Lys Val 
            580                 585                 590         


Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe Leu Ala Tyr Ser 
        595                 600                 605             


Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp Thr Asp Tyr Pro 
    610                 615                 620                 


Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu Ile Glu Arg Ile 
625                 630                 635                 640 


Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu Val Ala Gly Gln 
                645                 650                 655     


Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn Leu Asp Tyr Glu 
            660                 665                 670         


Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp Leu Asn Gln Tyr 
        675                 680                 685             


Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln Trp Leu Tyr Ser 
    690                 695                 700                 


Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu Thr Thr Asp Phe 
705                 710                 715                 720 


Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys Lys Leu Asn Asp 
                725                 730                 735     


Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro Tyr Val Ser Pro 
            740                 745                 750         


Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser Gly Ser His Thr 
        755                 760                 765             


Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys Gln Asn Asn Gly 
    770                 775                 780                 


Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala Leu Ala Thr Trp 
785                 790                 795                 800 


Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asp Ile 
                805                 810                 815     


Asp Asn Glu Phe Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Cys Asp 
            820                 825                 830         


Val Glu Trp Val Asp Val Ser Ser Leu Glu Trp Asp Leu Pro Cys 
        835                 840                 845         


<210>  54
<211>  859
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  54

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Cys Asp Val Glu Trp Val Asp Val Ser Ser 
            20                  25                  30          


Leu Glu Trp Asp Leu Pro Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Ser Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser Pro Glu Ser Pro Val 
    50                  55                  60                  


Val Gln Leu His Ser Asn Phe Thr Ala Val Cys Val Leu Lys Glu Lys 
65                  70                  75                  80  


Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr Ile Val Trp Lys Thr 
                85                  90                  95      


Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr Ile Ile Asn Arg Thr 
            100                 105                 110         


Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser Leu Asn Ile Gln Leu 
        115                 120                 125             


Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu Gln Asn Val Tyr Gly 
    130                 135                 140                 


Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys Pro Lys Asn Leu Ser 
145                 150                 155                 160 


Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys Glu Trp Asp Gly Gly 
                165                 170                 175     


Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu Lys Ser Glu Trp Ala 
            180                 185                 190         


Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg Asp Thr Pro Thr Ser 
        195                 200                 205             


Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val Asn Ile Glu Val Trp 
    210                 215                 220                 


Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr Ser Asp His Ile Asn 
225                 230                 235                 240 


Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser 
                245                 250                 255     


Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr 
            260                 265                 270         


Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr 
        275                 280                 285             


Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr 
    290                 295                 300                 


Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr 
305                 310                 315                 320 


Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr 
                325                 330                 335     


Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr Tyr Glu Asp Arg 
            340                 345                 350         


Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile Asp Pro Ser His Thr 
        355                 360                 365             


Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys Thr Leu Pro Pro Phe 
    370                 375                 380                 


Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr Leu Thr Arg Trp 
385                 390                 395                 400 


Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr Lys Leu Thr Val 
                405                 410                 415     


Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr Val Arg Asn Leu 
            420                 425                 430         


Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro Ala Cys Asp Phe 
        435                 440                 445             


Gln Ala Thr His Pro Val Met Asp Leu Lys Ala Phe Pro Lys Asp Asn 
    450                 455                 460                 


Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser Val Lys Lys Tyr 
465                 470                 475                 480 


Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro Cys Ile Thr Asp 
                485                 490                 495     


Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr Leu Arg Gly Asn 
            500                 505                 510         


Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr Pro Val Tyr Ala 
        515                 520                 525             


Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr Leu Lys Gln Ala 
    530                 535                 540                 


Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys Val Gly Lys Asn 
545                 550                 555                 560 


Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp Val Gln Asn Gly 
                565                 570                 575     


Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile Ile Gly Asn Glu 
            580                 585                 590         


Thr Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr Thr Leu Ser Ser 
        595                 600                 605             


Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala Tyr Thr Asp 
    610                 615                 620                 


Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr Pro Lys Phe 
625                 630                 635                 640 


Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe 
                645                 650                 655     


Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp 
            660                 665                 670         


Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro Ser Lys Ser 
        675                 680                 685             


His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His Asn Phe Asn 
    690                 695                 700                 


Ser Lys Asp Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu 
705                 710                 715                 720 


Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
                725                 730                 735     


Val Gly Glu Arg Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu 
            740                 745                 750         


Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile Gln Ala Gln 
        755                 760                 765             


Thr Ala Tyr Ser Ala Asn Pro Ala Ser Gln Ala Phe Val Leu Val Asp 
    770                 775                 780                 


Ala Ser Ala Ala Leu Pro Pro Asp Gly Asn Leu Tyr Pro Lys Leu Tyr 
785                 790                 795                 800 


Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Ala Glu Ile 
                805                 810                 815     


Cys Glu Ser Met Pro Met Val Ser Gly Ala Pro Ala Gln Gly Gln Leu 
            820                 825                 830         


Val Ala Arg Pro Ser Ser Val Asn Tyr Met Val Ala Pro Val Thr Gly 
        835                 840                 845             


Asn Asp Ala Gly Ile Arg Arg Ala Glu Ile Lys 
    850                 855                 


<210>  55
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  55

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Asn Gly Gly Gly Gly Ser Gly Arg Gly Tyr Ile Pro 
        195                 200                 205             


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
    210                 215                 220                 


Val Phe Leu Ser Thr Phe Leu Ser Pro Ala Asn Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Arg Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
                245                 250                 255     


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
            260                 265                 270         


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
        275                 280                 285             


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Pro Gln Gly Thr Glu 
    290                 295                 300                 


Asp Ser Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu 
305                 310                 315                 320 


Cys Leu Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg 
                325                 330                 335     


Trp Lys Gly Thr Asn Gly Gly Gly Gly Ser Gly Arg Gly Tyr Ile Pro 
            340                 345                 350         


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
        355                 360                 365             


Val Phe Leu Ser Thr Phe Leu Ser Pro Ala Asn Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Arg Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val 
385                 390                 395                 400 


Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile 
                405                 410                 415     


Leu Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro 
            420                 425                 430         


Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Glu Gly 
        435                 440                 445             


Gly 
    


<210>  56
<211>  608
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  56

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Gly 
                405                 410                 415     


Ser Gly Ser Gly Ser Gly Ser Gly Ser Glu Glu Lys Arg Arg Ile Arg 
            420                 425                 430         


Arg Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg 
        435                 440                 445             


Glu Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu 
    450                 455                 460                 


Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu 
465                 470                 475                 480 


Lys Leu Glu Phe Ile Leu Ala Ala His Gly Ser Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys 
            500                 505                 510         


Val Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala 
        515                 520                 525             


Ile Leu Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr 
    530                 535                 540                 


Pro Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu 
                565                 570                 575     


Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala 
            580                 585                 590         


Pro Val Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln 
        595                 600                 605             


<210>  57
<211>  805
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  57

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Ile 
    610                 615                 620                 


Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys 
625                 630                 635                 640 


Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
                645                 650                 655     


Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
            660                 665                 670         


Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn His Gly Ser 
        675                 680                 685             


Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu Asp 
    690                 695                 700                 


Leu Lys Val Asp Lys Val Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn 
705                 710                 715                 720 


Pro Ala Asn Pro Ala Ile Leu Ser Glu Ala Ser Ala Pro Ile Pro His 
                725                 730                 735     


Asp Gly Asn Leu Tyr Pro Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met 
            740                 745                 750         


Gly Leu Ser Leu Asn Glu Glu Glu Ile Arg Ala Asn Val Ala Val Val 
        755                 760                 765             


Ser Gly Ala Pro Leu Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Ile 
    770                 775                 780                 


Asn Tyr Met Val Ala Pro Val Thr Gly Asn Asp Val Gly Ile Arg Arg 
785                 790                 795                 800 


Ala Glu Ile Lys Gln 
                805 


<210>  58
<211>  752
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  58

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Arg Met Lys Gln Leu Glu Asp Lys 
        595                 600                 605             


Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
    610                 615                 620                 


Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Ser Gly Ser Gly Ser Gly 
625                 630                 635                 640 


Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys 
                645                 650                 655     


Val Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala 
            660                 665                 670         


Ile Leu Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr 
        675                 680                 685             


Pro Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn 
    690                 695                 700                 


Glu Glu Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu 
705                 710                 715                 720 


Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala 
                725                 730                 735     


Pro Val Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln 
            740                 745                 750         


<210>  59
<211>  275
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  59

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Thr Gln Gly Ser Leu Asn Ser 
145                 150                 155                 160 


Leu Ser Gly Glu Ser Gly Glu Leu Glu Glu Pro Ile Glu Ser Asn Glu 
                165                 170                 175     


Ile Asp Leu Thr Ile Asp Ser Asp Leu Arg Pro Lys Ser Ser Trp Glu 
            180                 185                 190         


Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp Ser Cys Cys Ile 
        195                 200                 205             


Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu Lys Ala Ile His 
    210                 215                 220                 


Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu Arg Lys Asn Val 
225                 230                 235                 240 


Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe Val Glu Val Leu 
                245                 250                 255     


Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr 
            260                 265                 270         


Glu Val Met 
        275 


<210>  60
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  60

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Pro Glu Glu Asn Glu Pro Ala Gln Thr Leu Pro Ala Leu Lys 
            20                  25                  30          


Pro Arg Glu Asn Asp Leu Asp Ser Trp Glu Leu Glu Lys Glu Ser Pro 
        35                  40                  45              


Val Ala Ser Trp Ser Gly Pro Ala Leu Gln Glu Pro Asp Gly Asp Glu 
    50                  55                  60                  


Leu Ser Glu Ser Ser Leu Ser Thr Ser Glu Leu Gly Ala Met Lys Lys 
65                  70                  75                  80  


His Lys Gly Gly Leu Leu Arg Lys Gly Ala Lys Leu Phe Phe Arg Arg 
                85                  90                  95      


Arg His Gln Gln Lys Asp Pro Gly Leu Ser Gln Ser His Asn Asp Leu 
            100                 105                 110         


Val Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly 
        115                 120                 125             


Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr His Glu Leu His Ile 
    130                 135                 140                 


Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met Val Gly Gln Gly Thr 
145                 150                 155                 160 


Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn Leu Lys Ser Thr Lys 
                165                 170                 175     


Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val Pro His Ile Gly Tyr 
            180                 185                 190         


Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly Met Ser Pro Phe Gln 
        195                 200                 205             


Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val His Arg Thr Met Gln 
    210                 215                 220                 


Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr Arg Tyr Thr Tyr Glu 
225                 230                 235                 240 


Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys Gly Thr Gly Phe Pro 
                245                 250                 255     


Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr Ala Ala Asp Trp Cys 
            260                 265                 270         


Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr Ile Ile Ser Thr Phe 
        275                 280                 285             


Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr Ala 
    290                 295                 300                 


Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu Lys 
305                 310                 315                 320 


Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu Leu Lys His Ser Lys 
                325                 330                 335     


Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala Phe Thr Asp Val Met 
            340                 345                 350         


Gly Met Asp Glu Leu Tyr Lys 
        355                 


<210>  61
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  61

Met Ser Ala Pro Arg Ile Trp Leu Ala Gln Ala Leu Leu Phe Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Ile Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu 
            20                  25                  30          


Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys Gln Gly 
        35                  40                  45              


Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr Asp Glu 
    50                  55                  60                  


Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Ser 
65                  70                  75                  80  


Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Tyr Thr Leu Ser Gln Gly 
                85                  90                  95      


Trp Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly 
            100                 105                 110         


Met Val Trp Gln Asp Arg Asp Thr Pro Lys Phe Ala Gln Gly Glu Ile 
        115                 120                 125             


Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu 
    130                 135                 140                 


Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His 
145                 150                 155                 160 


Ile Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys 
                165                 170                 175     


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 
            180                 185                 190         


Glu Arg Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Tyr Pro 
        195                 200                 205             


Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile Gln Ala Gln Thr Ala 
    210                 215                 220                 


Tyr Ser Ala Asn Pro Ala Ser Gln Ala Phe Val Leu Val Asp Ala Ser 
225                 230                 235                 240 


Ala Ala Leu Pro Pro Asp Gly Asn Leu Tyr Pro Lys Leu Tyr Pro Glu 
                245                 250                 255     


Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Ala Glu Ile Cys Glu 
            260                 265                 270         


Ser Met Pro Met Val Ser Gly Ala Pro Ala Gln Gly Gln Leu Val Ala 
        275                 280                 285             


Arg Pro Ser Ser Val Asn Tyr Met Val Ala Pro Val Thr Gly Asn Asp 
    290                 295                 300                 


Ala Gly Ile Arg Arg Ala Glu Ile Lys 
305                 310             


<210>  62
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  62

Met Ser Ala Pro Arg Ile Trp Leu Ala Gln Ala Leu Leu Phe Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Ile Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu 
            20                  25                  30          


Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys Gln Gly 
        35                  40                  45              


Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr Asp Glu 
    50                  55                  60                  


Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Ser 
65                  70                  75                  80  


Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Thr Leu Ala Val Pro Phe 
                85                  90                  95      


Lys Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly 
            100                 105                 110         


Met Val Trp Gln Asp Arg Asp Thr Pro Lys Phe Ala Gln Gly Glu Ile 
        115                 120                 125             


Glu Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu 
    130                 135                 140                 


Leu Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His 
145                 150                 155                 160 


Ile Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys 
                165                 170                 175     


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 
            180                 185                 190         


Glu Arg Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Tyr Pro 
        195                 200                 205             


Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile Gln Ala Gln Thr Ala 
    210                 215                 220                 


Tyr Ser Ala Asn Pro Ala Ser Gln Ala Phe Val Leu Val Asp Ala Ser 
225                 230                 235                 240 


Ala Ala Leu Pro Pro Asp Gly Asn Leu Tyr Pro Lys Leu Tyr Pro Glu 
                245                 250                 255     


Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Ala Glu Ile Cys Glu 
            260                 265                 270         


Ser Met Pro Met Val Ser Gly Ala Pro Ala Gln Gly Gln Leu Val Ala 
        275                 280                 285             


Arg Pro Ser Ser Val Asn Tyr Met Val Ala Pro Val Thr Gly Asn Asp 
    290                 295                 300                 


Ala Gly Ile Arg Arg Ala Glu Ile Lys 
305                 310             


<210>  63
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  63

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Gln Arg Gly Asn Arg Thr Leu Ala Val Pro Phe Lys Gln Ala Ala Thr 
                165                 170                 175     


Ala Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
            180                 185                 190         


Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
        195                 200                 205             


Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
    210                 215                 220                 


Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
225                 230                 235                 240 


Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
                245                 250             


<210>  64
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  64

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Ala Cys Ala Val Gly Leu Ile Ala Val Gly 
            20                  25                  30          


Val Gly Ala Gln Leu Val Leu Ser Gln Thr Ile Ile Gln Gly Ala Thr 
        35                  40                  45              


Pro Gly Ser Leu Leu Pro Val Val Ile Ile Ala Val Gly Val Phe Leu 
    50                  55                  60                  


Phe Leu Val Ala Phe Val Gly Cys Cys Gly Ala Cys Lys Glu Asn Tyr 
65                  70                  75                  80  


Cys Leu Met Ile Thr Phe Ala Ile Phe Leu Ser Leu Ile Met Leu Val 
                85                  90                  95      


Glu Val Ala Ala Ala Ile Ala Gly Tyr Val Phe Arg Asp Lys Val Met 
            100                 105                 110         


Ser Glu Phe Asn Asn Asn Phe Arg Gln Gln Met Glu Asn Tyr Pro Lys 
        115                 120                 125             


Asn Asn His Thr Ala Ser Ile Leu Asp Arg Met Gln Ala Asp Phe Lys 
    130                 135                 140                 


Cys Cys Gly Ala Ala Asn Tyr Thr Asp Trp Glu Lys Ile Pro Ser Met 
145                 150                 155                 160 


Gln Arg Gly Asn Arg Tyr Thr Leu Ser Gln Gly Trp Gln Ala Ala Thr 
                165                 170                 175     


Ala Asn Arg Val Pro Asp Ser Cys Cys Ile Asn Val Thr Val Gly Cys 
            180                 185                 190         


Gly Ile Asn Phe Asn Glu Lys Ala Ile His Lys Glu Gly Cys Val Glu 
        195                 200                 205             


Lys Ile Gly Gly Trp Leu Arg Lys Asn Val Leu Val Val Ala Ala Ala 
    210                 215                 220                 


Ala Leu Gly Ile Ala Phe Val Glu Val Leu Gly Ile Val Phe Ala Cys 
225                 230                 235                 240 


Cys Leu Val Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
                245                 250             


<210>  65
<211>  267
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  65

Met Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys 
1               5                   10                  15      


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 
            20                  25                  30          


Glu Arg Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly 
        35                  40                  45              


Glu Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly 
    50                  55                  60                  


Asp Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn 
65                  70                  75                  80  


Ala Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser 
                85                  90                  95      


Gly Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile 
            100                 105                 110         


Gly Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys 
        115                 120                 125             


Thr Glu Cys Glu Gly Leu Ala Gly Thr Glu Ser Pro Gly Gly Glu Glu 
    130                 135                 140                 


Pro Gly Glu Asp Phe Pro Ala Ala Arg Arg His His His His His His 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Pro Ala Met Ala Ser His 
                165                 170                 175     


Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe 
            180                 185                 190         


Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met 
        195                 200                 205             


Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu 
    210                 215                 220                 


Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Thr Leu 
225                 230                 235                 240 


Ala Val Pro Phe Lys Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly 
                245                 250                 255     


Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
            260                 265         


<210>  66
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  67
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  68
<211>  514
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  68

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Arg Met Lys Gln Leu Glu 
        355                 360                 365             


Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu 
    370                 375                 380                 


Val Ala Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Ser Gly Ser Gly 
385                 390                 395                 400 


Ser Gly Ser Gly Ser Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val 
                405                 410                 415     


Asp Lys Val Ile Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn 
            420                 425                 430         


Pro Ala Ile Leu Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn 
        435                 440                 445             


Leu Tyr Pro Arg Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser 
    450                 455                 460                 


Leu Asn Glu Glu Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala 
465                 470                 475                 480 


Pro Leu Gln Gly Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met 
                485                 490                 495     


Val Ala Pro Val Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile 
            500                 505                 510         


Lys Gln 
        


<210>  69
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  69

Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln 
1               5                   10                  15      


Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu 
            20                  25                  


<210>  70
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  71
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  72
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Leu Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  73
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  74
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Lys Pro Gly Pro Pro His Arg Ala Gly Ala Ala His Gly Ala Gly 
1               5                   10                  15      


Ala Gly Ala Gly Ala Ala Ala Gly Pro Gly Ala Arg Gly Leu Leu Leu 
            20                  25                  30          


Pro Pro Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln 
        35                  40                  45              


Arg Trp Arg Ser Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser 
    50                  55                  60                  


Gly Asp Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Ile Glu Thr Ala 
                85                  90                  95      


Met Arg Phe Ser Pro Asp Val Ala Leu Ala Val Ser Thr Thr Pro Ala 
            100                 105                 110         


Val Leu Pro Thr Thr Asn Ile Gln Pro Val Gly Thr Pro Phe Glu Glu 
        115                 120                 125             


Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro Ala Thr Ser Pro Leu Val 
    130                 135                 140                 


Val Thr Glu Val Pro Glu Glu Pro Ser Gln Arg Ala Thr Thr Val Ser 
145                 150                 155                 160 


Thr Thr Met Ala Thr Thr Ala Ala Thr Ser Thr Gly Asp Pro Thr Val 
                165                 170                 175     


Ala Thr Val Pro Ala Thr Val Ala Thr Ala Thr Pro Ser Thr Pro Ala 
            180                 185                 190         


Ala Pro Pro Phe Thr Ala Thr Thr Ala Val Ile Arg Thr Thr Gly Val 
        195                 200                 205             


Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr Val Ala Thr Ala Arg Ala 
    210                 215                 220                 


Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr Thr Ala Ala Val Leu Asp 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Pro Arg Leu Val Ser Thr Ala Thr Ser Arg Pro 
                245                 250                 255     


Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln Glu Pro Asp Ile Pro Glu 
            260                 265                 270         


Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu Val 
        275                 280                 285             


Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu Thr Thr Ile Arg Asp Glu 
    290                 295                 300                 


Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu Pro 
305                 310                 315                 320 


Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val 
                325                 330                 335     


Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro Pro Gly Thr Leu Pro Lys 
            340                 345                 350         


Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp Asn Ala Ile Asp Ser Gly 
        355                 360                 365             


Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu 
    370                 375                 380                 


Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala 
385                 390                 395                 400 


Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu 
                405                 410                 415     


Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln 
            420                 425                 430         


Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala 
        435                 440         


<210>  75
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  76
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu Pro 
1               5                   10                  15      


Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp Asn 
            20                  25                  30          


Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala Asp 
        35                  40                  45              


Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys 
    50                  55                  


<210>  77
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210>  78
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210>  79
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  80
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  81
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Gln Val Ser Lys Arg Met Leu Ala Gly Gly Val Arg Ser Met Pro 
1               5                   10                  15      


Ser Pro Leu Leu Ala Cys Trp Gln Pro Ile Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Ser Val Leu Ser Gly Ser Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys 
        35                  40                  45              


Ser Ala Gln Asp Arg Ala Val Leu Cys His Arg Lys Arg Phe Val Ala 
    50                  55                  60                  


Val Pro Glu Gly Ile Pro Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys 
65                  70                  75                  80  


Asn Arg Ile Lys Thr Leu Asn Gln Asp Glu Phe Ala Ser Phe Pro His 
                85                  90                  95      


Leu Glu Glu Leu Glu Leu Asn Glu Asn Ile Val Ser Ala Val Glu Pro 
            100                 105                 110         


Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser 
        115                 120                 125             


Asn Arg Leu Lys Leu Ile Pro Leu Gly Val Phe Thr Gly Leu Ser Asn 
    130                 135                 140                 


Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu Leu Asp 
145                 150                 155                 160 


Tyr Met Phe Gln Asp Leu Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp 
                165                 170                 175     


Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu Asn Ser 
            180                 185                 190         


Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr 
        195                 200                 205             


Glu Ala Leu Ser His Leu His Gly Leu Ile Val Leu Arg Leu Arg His 
    210                 215                 220                 


Leu Asn Ile Asn Ala Ile Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg 
225                 230                 235                 240 


Leu Lys Val Leu Glu Ile Ser His Trp Pro Tyr Leu Asp Thr Met Thr 
                245                 250                 255     


Pro Asn Cys Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Ile Thr His 
            260                 265                 270         


Cys Asn Leu Thr Ala Val Pro Tyr Leu Ala Val Arg His Leu Val Tyr 
        275                 280                 285             


Leu Arg Phe Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly 
    290                 295                 300                 


Ser Met Leu His Glu Leu Leu Arg Leu Gln Glu Ile Gln Leu Val Gly 
305                 310                 315                 320 


Gly Gln Leu Ala Val Val Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr 
                325                 330                 335     


Leu Arg Val Leu Asn Val Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu 
            340                 345                 350         


Ser Val Phe His Ser Val Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser 
        355                 360                 365             


Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Val Phe Arg Arg Arg 
    370                 375                 380                 


Trp Arg Leu Asn Phe Asn Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu 
385                 390                 395                 400 


Phe Val Gln Gly Lys Glu Phe Lys Asp Phe Pro Asp Val Leu Leu Pro 
                405                 410                 415     


Asn Tyr Phe Thr Cys Arg Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln 
            420                 425                 430         


Gln Val Phe Val Asp Glu Gly His Thr Val Gln Phe Val Cys Arg Ala 
        435                 440                 445             


Asp Gly Asp Pro Pro Pro Ala Ile Leu Trp Leu Ser Pro Arg Lys His 
    450                 455                 460                 


Leu Val Ser Ala Lys Ser Asn Gly Arg Leu Thr Val Phe Pro Asp Gly 
465                 470                 475                 480 


Thr Leu Glu Val Arg Tyr Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu 
                485                 490                 495     


Cys Ile Ala Ala Asn Ala Gly Gly Asn Asp Ser Met Pro Ala His Leu 
            500                 505                 510         


His Val Arg Ser Tyr Ser Pro Asp Trp Pro His Gln Pro Asn Lys Thr 
        515                 520                 525             


Phe Ala Phe Ile Ser Asn Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr 
    530                 535                 540                 


Arg Ala Thr Val Pro Phe Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala 
545                 550                 555                 560 


Thr Thr Met Gly Phe Ile Ser Phe Leu Gly Val Val Leu Phe Cys Leu 
                565                 570                 575     


Val Leu Leu Phe Leu Trp Ser Arg Gly Lys Gly Asn Thr Lys His Asn 
            580                 585                 590         


Ile Glu Ile Glu Tyr Val Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser 
        595                 600                 605             


Ala Asp Ala Pro Arg Lys Phe Asn Met Lys Met Ile 
    610                 615                 620 


<210>  82
<211>  20
<212>  PRT
<213>  Haemophilus influenzae

<400>  82

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly 
            20  


<210>  83
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys Tyr 
1               5                   10                  15      


Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr Lys 
            20                  25                  30          


Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser Ser 
        35                  40                  45              


Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg Gly 
    50                  55                  60                  


Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr Pro 
65                  70                  75                  80  


Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr Ile 
                85                  90                  95      


Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro Tyr 
            100                 105                 110         


Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile Gln 
        115                 120                 125             


Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg Pro 
    130                 135                 140                 


Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn Thr 
145                 150                 155                 160 


Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser Gly 
                165                 170                 175     


Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro Gly 
            180                 185                 190         


Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro Pro 
        195                 200                 205             


Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp Thr 
    210                 215                 220                 


Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp Arg 
225                 230                 235                 240 


Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu Lys 
                245                 250                 255     


Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu Met 
            260                 265                 270         


Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile Glu 
        275                 280                 285             


Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys Met 
    290                 295                 300                 


Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro Thr 
305                 310                 315                 320 


Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn Ala 
                325                 330                 335     


Ile Glu Asp Thr Ile Phe Tyr Leu Gly Glu Ala Leu Arg Arg Gly Val 
            340                 345                 350         


Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg Lys 
        355                 360                 365             


Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala Gly 
    370                 375                 380                 


Leu Ser Asp Leu Tyr 
385                 


<210>  84
<211>  29
<212>  PRT
<213>  Rabies virus

<400>  84

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  


<210>  85
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser 
            100 


<210>  86
<211>  59
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  86

Leu Ile Ser Glu Glu Asp Leu Leu Gln Ser Arg Pro Glu Pro Thr Ala 
1               5                   10                  15      


Pro Pro Glu Glu Ser Phe Arg Ser Gly Val Glu Thr Thr Thr Pro Pro 
            20                  25                  30          


Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr Pro Leu Thr Ser Leu 
        35                  40                  45              


Arg Ser Leu Phe Gly Asn Asp Pro Ser Ser Gln 
    50                  55                  


<210>  87
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  87

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Asn Gly Gly Gly Gly Ser Gly Arg Gly Tyr Ile Pro 
        195                 200                 205             


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
    210                 215                 220                 


Val Phe Leu Ser Thr Phe Leu Ser Pro Ala Asn Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Arg Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
                245                 250                 255     


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
            260                 265                 270         


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
        275                 280                 285             


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Pro Gln Gly Thr Glu 
    290                 295                 300                 


Asp Ser Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu 
305                 310                 315                 320 


Cys Leu Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg 
                325                 330                 335     


Trp Lys Gly Thr Asn Gly Gly Gly Gly Ser Gly Arg Gly Tyr Ile Pro 
            340                 345                 350         


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
        355                 360                 365             


Val Phe Leu Ser Thr Phe Leu Ser Pro Ala Asn Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Leu Ile Ser Glu Glu Asp Leu Leu Gln Ser Arg Pro Glu Pro Thr 
385                 390                 395                 400 


Ala Pro Pro Glu Glu Ser Phe Arg Ser Gly Val Glu Thr Thr Thr Pro 
                405                 410                 415     


Pro Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr Pro Leu Thr Ser 
            420                 425                 430         


Leu Arg Ser Leu Phe Gly Asn Asp Pro Ser Ser Gln 
        435                 440                 


<210>  88
<211>  570
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion polypeptide comprising at least one human sequence fused 
       to at least one sequence deriving from any other species

<400>  88

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
            500                 505                 510         


Ile Ser Glu Glu Asp Leu Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro 
        515                 520                 525             


Pro Glu Glu Ser Phe Arg Ser Gly Val Glu Thr Thr Thr Pro Pro Gln 
    530                 535                 540                 


Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr Pro Leu Thr Ser Leu Arg 
545                 550                 555                 560 


Ser Leu Phe Gly Asn Asp Pro Ser Ser Gln 
                565                 570 


