                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  GENE THERAPY FOR TREATING FAMILIAL HYPERCHOLESTEROLEMIA

<130>  UPN-16-7717C1PCT

<150>  US 62/461,015
<151>  2017-02-20

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  5292
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (1)..(254)

<220>
<221>  misc_feature
<222>  (188)..(2770)
<223>  LDLR isoform 1 encoded by full-length CDS, 188-2770;  other 
       variants encoded by alternative splice variants missing an exon; 
       most common variant missing fourth exon or twelfth exon

<220>
<221>  misc_signal
<222>  (188)..(250)

<220>
<221>  misc_feature
<222>  (251)..(2767)
<223>  Mature protein of isoform 1

<220>
<221>  exon
<222>  (255)..(377)

<220>
<221>  exon
<222>  (378)..(500)

<220>
<221>  exon
<222>  (501)..(881)

<220>
<221>  exon
<222>  (882)..(1004)

<220>
<221>  exon
<222>  (1005)..(1127)

<220>
<221>  exon
<222>  (1128)..(1247)

<220>
<221>  exon
<222>  (1248)..(1373)

<220>
<221>  exon
<222>  (1374)..(1545)

<220>
<221>  exon
<222>  (1546)..(1773)

<220>
<221>  exon
<222>  (1774)..(1892)

<220>
<221>  exon
<222>  (1893)..(2032)

<220>
<221>  exon
<222>  (2033)..(2174)

<220>
<221>  exon
<222>  (2175)..(2327)

<220>
<221>  exon
<222>  (2328)..(2498)

<220>
<221>  polyA_signal
<222>  (5252)..(5257)

<220>
<221>  polyA_site
<222>  (5284)..(5284)

<400>  1
ctc ttg cag tga ggt gaa gac att tga aaa tca ccc cac tgc aaa ctc         48
Leu Leu Gln     Gly Glu Asp Ile     Lys Ser Pro His Cys Lys Leu           
1                   5                       10                            

ctc ccc ctg cta gaa acc tca cat tga aat gct gta aat gac gtg ggc         96
Leu Pro Leu Leu Glu Thr Ser His     Asn Ala Val Asn Asp Val Gly           
15                  20                      25                            

ccc gag tgc aat cgc ggg aag cca ggg ttt cca gct agg aca cag cag        144
Pro Glu Cys Asn Arg Gly Lys Pro Gly Phe Pro Ala Arg Thr Gln Gln           
30                  35                  40                  45            

gtc gtg atc cgg gtc ggg aca ctg cct ggc aga ggc tgc gag cat ggg        192
Val Val Ile Arg Val Gly Thr Leu Pro Gly Arg Gly Cys Glu His Gly           
                50                  55                  60                

gcc ctg ggg ctg gaa att gcg ctg gac cgt cgc ctt gct cct cgc cgc        240
Ala Leu Gly Leu Glu Ile Ala Leu Asp Arg Arg Leu Ala Pro Arg Arg           
            65                  70                  75                    

ggc ggg gac tgc ag  t ggg cga cag atg cga aag aaa cga gtt cca gtg      288
Gly Gly Asp Cys Ser   Gly Arg Gln Met Arg Lys Lys Arg Val Pro Val         
        80                    85                  90                      

cca aga cgg gaa atg cat ctc cta caa gtg ggt ctg cga tgg cag cgc        336
Pro Arg Arg Glu Met His Leu Leu Gln Val Gly Leu Arg Trp Gln Arg           
    95                  100                 105                           

tga gtg cca gga tgg ctc tga tga gtc cca gga gac gtg ct  t gtc tgt      384
    Val Pro Gly Trp Leu         Val Pro Gly Asp Val Leu   Val Cys         
    110                         115                 120                   

cac ctg caa atc cgg gga ctt cag ctg tgg ggg ccg tgt caa ccg ctg        432
His Leu Gln Ile Arg Gly Leu Gln Leu Trp Gly Pro Cys Gln Pro Leu           
        125                 130                 135                       

cat tcc tca gtt ctg gag gtg cga tgg cca agt gga ctg cga caa cgg        480
His Ser Ser Val Leu Glu Val Arg Trp Pro Ser Gly Leu Arg Gln Arg           
    140                 145                 150                           

ctc aga cga gca agg ctg tc  c ccc caa gac gtg ctc cca gga cga gtt      528
Leu Arg Arg Ala Arg Leu Ser   Pro Gln Asp Val Leu Pro Gly Arg Val         
155                 160                   165                 170         

tcg ctg cca cga tgg gaa gtg cat ctc tcg gca gtt cgt ctg tga ctc        576
Ser Leu Pro Arg Trp Glu Val His Leu Ser Ala Val Arg Leu     Leu           
                175                 180                     185           

aga ccg gga ctg ctt gga cgg ctc aga cga ggc ctc ctg ccc ggt gct        624
Arg Pro Gly Leu Leu Gly Arg Leu Arg Arg Gly Leu Leu Pro Gly Ala           
                190                 195                 200               

cac ctg tgg tcc cgc cag ctt cca gtg caa cag ctc cac ctg cat ccc        672
His Leu Trp Ser Arg Gln Leu Pro Val Gln Gln Leu His Leu His Pro           
            205                 210                 215                   

cca gct gtg ggc ctg cga caa cga ccc cga ctg cga aga tgg ctc gga        720
Pro Ala Val Gly Leu Arg Gln Arg Pro Arg Leu Arg Arg Trp Leu Gly           
        220                 225                 230                       

tga gtg gcc gca gcg ctg tag ggg tct tta cgt gtt cca agg gga cag        768
    Val Ala Ala Ala Leu     Gly Ser Leu Arg Val Pro Arg Gly Gln           
        235                     240                 245                   

tag ccc ctg ctc ggc ctt cga gtt cca ctg cct aag tgg cga gtg cat        816
    Pro Leu Leu Gly Leu Arg Val Pro Leu Pro Lys Trp Arg Val His           
            250                 255                 260                   

cca ctc cag ctg gcg ctg tga tgg tgg ccc cga ctg caa gga caa atc        864
Pro Leu Gln Leu Ala Leu     Trp Trp Pro Arg Leu Gln Gly Gln Ile           
        265                     270                 275                   

tga cga gga aaa ctg cg  c tgt ggc cac ctg tcg ccc tga cga att cca      912
    Arg Gly Lys Leu Arg   Cys Gly His Leu Ser Pro     Arg Ile Pro         
            280                   285                     290             

gtg ctc tga tgg aaa ctg cat cca tgg cag ccg gca gtg tga ccg gga        960
Val Leu     Trp Lys Leu His Pro Trp Gln Pro Ala Val     Pro Gly           
                295                 300                     305           

ata tga ctg caa gga cat gag cga tga agt tgg ctg cgt taa tg  t gac     1008
Ile     Leu Gln Gly His Glu Arg     Ser Trp Leu Arg     Cys   Asp         
                    310                     315                           

act ctg cga ggg acc caa caa gtt caa gtg tca cag cgg cga atg cat       1056
Thr Leu Arg Gly Thr Gln Gln Val Gln Val Ser Gln Arg Arg Met His           
    320                 325                 330                           

cac cct gga caa agt ctg caa cat ggc tag aga ctg ccg gga ctg gtc       1104
His Pro Gly Gln Ser Leu Gln His Gly     Arg Leu Pro Gly Leu Val           
335                 340                     345                           

aga tga acc cat caa aga gtg cg  g gac caa cga atg ctt gga caa caa     1152
Arg     Thr His Gln Arg Val Arg   Asp Gln Arg Met Leu Gly Gln Gln         
350                     355                   360                         

cgg cgg ctg ttc cca cgt ctg caa tga cct taa gat cgg cta cga gtg       1200
Arg Arg Leu Phe Pro Arg Leu Gln     Pro     Asp Arg Leu Arg Val           
365                 370                         375                       

cct gtg ccc cga cgg ctt cca gct ggt ggc cca gcg aag atg cga ag  a     1248
Pro Val Pro Arg Arg Leu Pro Ala Gly Gly Pro Ala Lys Met Arg Arg           
    380                 385                 390                           

tat cga tga gtg tca gga tcc cga cac ctg cag cca gct ctg cgt gaa       1296
Tyr Arg     Val Ser Gly Ser Arg His Leu Gln Pro Ala Leu Arg Glu           
395                     400                 405                           

cct gga ggg tgg cta caa gtg cca gtg tga gga agg ctt cca gct gga       1344
Pro Gly Gly Trp Leu Gln Val Pro Val     Gly Arg Leu Pro Ala Gly           
410                 415                     420                           

ccc cca cac gaa ggc ctg caa ggc tgt gg  g ctc cat cgc cta cct ctt     1392
Pro Pro His Glu Gly Leu Gln Gly Cys Gly   Leu His Arg Leu Pro Leu         
425                 430                   435                 440         

ctt cac caa ccg gca cga ggt cag gaa gat gac gct gga ccg gag cga       1440
Leu His Gln Pro Ala Arg Gly Gln Glu Asp Asp Ala Gly Pro Glu Arg           
                445                 450                 455               

gta cac cag cct cat ccc caa cct gag gaa cgt ggt cgc tct gga cac       1488
Val His Gln Pro His Pro Gln Pro Glu Glu Arg Gly Arg Ser Gly His           
            460                 465                 470                   

gga ggt ggc cag caa tag aat cta ctg gtc tga cct gtc cca gag aat       1536
Gly Gly Gly Gln Gln     Asn Leu Leu Val     Pro Val Pro Glu Asn           
        475                     480                     485               

gat ctg cag cac cca gct tga cag agc cca cgg cgt ctc ttc cta tga       1584
Asp Leu Gln His Pro Ala     Gln Ser Pro Arg Arg Leu Phe Leu               
            490                     495                 500               

cac cgt cat cag cag aga cat cca ggc ccc cga cgg gct ggc tgt gga       1632
His Arg His Gln Gln Arg His Pro Gly Pro Arg Arg Ala Gly Cys Gly           
                505                 510                 515               

ctg gat cca cag caa cat cta ctg gac cga ctc tgt cct ggg cac tgt       1680
Leu Asp Pro Gln Gln His Leu Leu Asp Arg Leu Cys Pro Gly His Cys           
            520                 525                 530                   

ctc tgt tgc gga tac caa ggg cgt gaa gag gaa aac gtt att cag gga       1728
Leu Cys Cys Gly Tyr Gln Gly Arg Glu Glu Glu Asn Val Ile Gln Gly           
        535                 540                 545                       

gaa cgg ctc caa gcc aag ggc cat cgt ggt gga tcc tgt tca tgg ctt       1776
Glu Arg Leu Gln Ala Lys Gly His Arg Gly Gly Ser Cys Ser Trp Leu           
    550                 555                 560                           

cat gta ctg gac tga ctg ggg aac tcc cgc caa gat caa gaa agg ggg       1824
His Val Leu Asp     Leu Gly Asn Ser Arg Gln Asp Gln Glu Arg Gly           
565                     570                 575                           

cct gaa tgg tgt gga cat cta ctc gct ggt gac tga aaa cat tca gtg       1872
Pro Glu Trp Cys Gly His Leu Leu Ala Gly Asp     Lys His Ser Val           
580                 585                 590                               

gcc caa tgg cat cac cct ag  a tct cct cag tgg ccg cct cta ctg ggt     1920
Ala Gln Trp His His Pro Arg   Ser Pro Gln Trp Pro Pro Leu Leu Gly         
595                 600                   605                 610         

tga ctc caa act tca ctc cat ctc aag cat cga tgt caa cgg ggg caa       1968
    Leu Gln Thr Ser Leu His Leu Lys His Arg Cys Gln Arg Gly Gln           
                    615                 620                 625           

ccg gaa gac cat ctt gga gga tga aaa gag gct ggc cca ccc ctt ctc       2016
Pro Glu Asp His Leu Gly Gly     Lys Glu Ala Gly Pro Pro Leu Leu           
                630                     635                 640           

ctt ggc cgt ctt tga g ga  caa agt att ttg gac aga tat cat caa cga     2064
Leu Gly Arg Leu       Gly Gln Ser Ile Leu Asp Arg Tyr His Gln Arg         
                      645                 650                 655         

agc cat ttt cag tgc caa ccg cct cac agg ttc cga tgt caa ctt gtt       2112
Ser His Phe Gln Cys Gln Pro Pro His Arg Phe Arg Cys Gln Leu Val           
                660                 665                 670               

ggc tga aaa cct act gtc ccc aga gga tat ggt tct ctt cca caa cct       2160
Gly     Lys Pro Thr Val Pro Arg Gly Tyr Gly Ser Leu Pro Gln Pro           
                675                 680                 685               

cac cca gcc aag ag  g agt gaa ctg gtg tga gag gac cac cct gag caa     2208
His Pro Ala Lys Arg   Ser Glu Leu Val     Glu Asp His Pro Glu Gln         
            690                   695                     700             

tgg cgg ctg cca gta tct gtg cct ccc tgc ccc gca gat caa ccc cca       2256
Trp Arg Leu Pro Val Ser Val Pro Pro Cys Pro Ala Asp Gln Pro Pro           
            705                 710                 715                   

ctc gcc caa gtt tac ctg cgc ctg ccc gga cgg cat gct gct ggc cag       2304
Leu Ala Gln Val Tyr Leu Arg Leu Pro Gly Arg His Ala Ala Gly Gln           
        720                 725                 730                       

gga cat gag gag ctg cct cac ag  a ggc tga ggc tgc agt ggc cac cca     2352
Gly His Glu Glu Leu Pro His Arg   Gly     Gly Cys Ser Gly His Pro         
    735                 740                       745                     

gga gac atc cac cgt cag gct aaa ggt cag ctc cac agc cgt aag gac       2400
Gly Asp Ile His Arg Gln Ala Lys Gly Gln Leu His Ser Arg Lys Asp           
    750                 755                 760                           

aca gca cac aac cac ccg acc tgt tcc cga cac ctc ccg gct gcc tgg       2448
Thr Ala His Asn His Pro Thr Cys Ser Arg His Leu Pro Ala Ala Trp           
765                 770                 775                 780           

ggc cac ccc tgg gct cac cac ggt gga gat agt gac aat gtc tca cca       2496
Gly His Pro Trp Ala His His Gly Gly Asp Ser Asp Asn Val Ser Pro           
                785                 790                 795               

ag ctctgggcga cgttgctggc agaggaaatg agaagaagcc cagtagcgtg             2548

agggctctgt ccattgtcct ccccatcgtg ctcctcgtct tcctttgcct gggggtcttc     2608

cttctatgga agaactggcg gcttaagaac atcaacagca tcaactttga caaccccgtc     2668

tatcagaaga ccacagagga tgaggtccac atttgccaca accaggacgg ctacagctac     2728

ccctcgagac agatggtcag tctggaggat gacgtggcgt gaacatctgc ctggagtccc     2788

gtccctgccc agaacccttc ctgagacctc gccggccttg ttttattcaa agacagagaa     2848

gaccaaagca ttgcctgcca gagctttgtt ttatatattt attcatctgg gaggcagaac     2908

aggcttcgga cagtgcccat gcaatggctt gggttgggat tttggtttct tcctttcctc     2968

gtgaaggata agagaaacag gcccgggggg accaggatga cacctccatt tctctccagg     3028

aagttttgag tttctctcca ccgtgacaca atcctcaaac atggaagatg aaaggggagg     3088

ggatgtcagg cccagagaag caagtggctt tcaacacaca acagcagatg gcaccaacgg     3148

gaccccctgg ccctgcctca tccaccaatc tctaagccaa acccctaaac tcaggagtca     3208

acgtgtttac ctcttctatg caagccttgc tagacagcca ggttagcctt tgccctgtca     3268

cccccgaatc atgacccacc cagtgtcttt cgaggtgggt ttgtaccttc cttaagccag     3328

gaaagggatt catggcgtcg gaaatgatct ggctgaatcc gtggtggcac cgagaccaaa     3388

ctcattcacc aaatgatgcc acttcccaga ggcagagcct gagtcactgg tcacccttaa     3448

tatttattaa gtgcctgaga cacccggtta ccttggccgt gaggacacgt ggcctgcacc     3508

caggtgtggc tgtcaggaca ccagcctggt gcccatcctc ccgaccccta cccacttcca     3568

ttcccgtggt ctccttgcac tttctcagtt cagagttgta cactgtgtac atttggcatt     3628

tgtgttatta ttttgcactg ttttctgtcg tgtgtgttgg gatgggatcc caggccaggg     3688

aaagcccgtg tcaatgaatg ccggggacag agaggggcag gttgaccggg acttcaaagc     3748

cgtgatcgtg aatatcgaga actgccattg tcgtctttat gtccgcccac ctagtgcttc     3808

cacttctatg caaatgcctc caagccattc acttccccaa tcttgtcgtt gatgggtatg     3868

tgtttaaaac atgcacggtg aggccgggcg cagtggctca cgcctgtaat cccagcactt     3928

tgggaggccg aggcgggtgg atcatgaggt caggagatcg agaccatcct ggctaacacg     3988

tgaaaccccg tctctactaa aaatacaaaa aattagccgg gcgtggtggc gggcacctgt     4048

agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccggga agcggagctt     4108

gcagtgagcc gagattgcgc cactgcagtc cgcagtctgg cctgggcgac agagcgagac     4168

tccgtctcaa aaaaaaaaaa caaaaaaaaa ccatgcatgg tgcatcagca gcccatggcc     4228

tctggccagg catggcgagg ctgaggtggg aggatggttt gagctcaggc atttgaggct     4288

gtcgtgagct atgattatgc cactgctttc cagcctgggc aacatagtaa gaccccatct     4348

cttaaaaaat gaatttggcc agacacaggt gcctcacgcc tgtaatccca gcactttggg     4408

aggctgagct ggatcacttg agttcaggag ttggagacca ggcctgagca acaaagcgag     4468

atcccatctc tacaaaaacc aaaaagttaa aaatcagctg ggtacggtgg cacgtgcctg     4528

tgatcccagc tacttgggag gctgaggcag gaggatcgcc tgagcccagg aggtggaggt     4588

tgcagtgagc catgatcgag ccactgcact ccagcctggg caacagatga agaccctatt     4648

tcagaaatac aactataaaa aaataaataa atcctccagt ctggatcgtt tgacgggact     4708

tcaggttctt tctgaaatcg ccgtgttact gttgcactga tgtccggaga gacagtgaca     4768

gcctccgtca gactcccgcg tgaagatgtc acaagggatt ggcaattgtc cccagggaca     4828

aaacactgtg tcccccccag tgcagggaac cgtgataagc ctttctggtt tcggagcacg     4888

taaatgcgtc cctgtacaga tagtggggat tttttgttat gtttgcactt tgtatattgg     4948

ttgaaactgt tatcacttat atatatatat atacacacat atatataaaa tctatttatt     5008

tttgcaaacc ctggttgctg tatttgttca gtgactattc tcggggccct gtgtaggggg     5068

ttattgcctc tgaaatgcct cttctttatg tacaaagatt atttgcacga actggactgt     5128

gtgcaacgct ttttgggaga atgatgtccc cgttgtatgt atgagtggct tctgggagat     5188

gggtgtcact ttttaaacca ctgtatagaa ggtttttgta gcctgaatgt cttactgtga     5248

tcaattaaat ttcttaaatg aaccaatttg tctaaaaaaa aaaa                      5292


<210>  2
<211>  2583
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2583)

<400>  2
atg ggg ccc tgg ggc tgg aaa ttg cgc tgg acc gtc gcc ttg ctc ctc         48
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu           
1               5                   10                  15                

gcc gcg gcg ggg act gca gtg ggc gac aga tgt gaa aga aac gag ttc         96
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe           
            20                  25                  30                    

cag tgc caa gac ggg aaa tgc atc tcc tac aag tgg gtc tgc gat ggc        144
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly           
        35                  40                  45                        

agc gct gag tgc cag gat ggc tct gat gag tcc cag gag acg tgc ttg        192
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu           
    50                  55                  60                            

tct gtc acc tgc aaa tcc ggg gac ttc agc tgt ggg ggc cgt gtc aac        240
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn           
65                  70                  75                  80            

cgc tgc att cct cag ttc tgg agg tgc gat ggc caa gtg gac tgc gac        288
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp           
                85                  90                  95                

aac ggc tca gac gag caa ggc tgt ccc ccc aag acg tgc tcc cag gac        336
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp           
            100                 105                 110                   

gag ttt cgc tgc cac gat ggg aag tgc atc tct cgg cag ttc gtc tgt        384
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys           
        115                 120                 125                       

gac tca gac cgg gac tgc ttg gac ggc tca gac gag gcc tcc tgc ccg        432
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro           
    130                 135                 140                           

gtg ctc acc tgt ggt ccc gcc agc ttc cag tgc aac agc tcc acc tgc        480
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys           
145                 150                 155                 160           

atc ccc cag ctg tgg gcc tgc gac aac gac ccc gac tgc gaa gat ggc        528
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly           
                165                 170                 175               

tcg gat gag tgg ccg cag cgc tgt agg ggt ctt tac gtg ttc caa ggg        576
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly           
            180                 185                 190                   

gac agt agc ccc tgc tcg gcc ttc gag ttc cac tgc cta agt ggc gag        624
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu           
        195                 200                 205                       

tgc atc cac tcc agc tgg cgc tgt gat ggt ggc ccc gac tgc aag gac        672
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp           
    210                 215                 220                           

aaa tct gac gag gaa aac tgc gct gtg gcc acc tgt cgc cct gac gaa        720
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu           
225                 230                 235                 240           

ttc cag tgc tct gat gga aac tgc atc cat ggc agc cgg cag tgt gac        768
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp           
                245                 250                 255               

cgg gaa tat gac tgc aag gac atg agc gat gaa gtt ggc tgc gtt aat        816
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn           
            260                 265                 270                   

gtg aca ctc tgc gag gga ccc aac aag ttc aag tgt cac agc ggc gaa        864
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu           
        275                 280                 285                       

tgc atc acc ctg gac aaa gtc tgc aac atg gct aga gac tgc cgg gac        912
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp           
    290                 295                 300                           

tgg tca gat gaa ccc atc aaa gag tgc ggg acc aac gaa tgc ttg gac        960
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp           
305                 310                 315                 320           

aac aac ggc ggc tgt tcc cac gtc tgc aat gac ctt aag atc ggc tac       1008
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr           
                325                 330                 335               

gag tgc ctg tgc ccc gac ggc ttc cag ctg gtg gcc cag cga aga tgc       1056
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys           
            340                 345                 350                   

gaa gat atc gat gag tgt cag gat ccc gac acc tgc agc cag ctc tgc       1104
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys           
        355                 360                 365                       

gtg aac ctg gag ggt ggc tac aag tgc cag tgt gag gaa ggc ttc cag       1152
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln           
    370                 375                 380                           

ctg gac ccc cac acg aag gcc tgc aag gct gtg ggc tcc atc gcc tac       1200
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr           
385                 390                 395                 400           

ctc ttc ttc acc aac cgg cac gag gtc agg aag atg acg ctg gac cgg       1248
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg           
                405                 410                 415               

agc gag tac acc agc ctc atc ccc aac ctg agg aac gtg gtc gct ctg       1296
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu           
            420                 425                 430                   

gac acg gag gtg gcc agc aat aga atc tac tgg tct gac ctg tcc cag       1344
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln           
        435                 440                 445                       

aga atg atc tgc agc acc cag ctt gac aga gcc cac ggc gtc tct tcc       1392
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser           
    450                 455                 460                           

tat gac acc gtc atc agc agg gac atc cag gcc ccc gac ggg ctg gct       1440
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala           
465                 470                 475                 480           

gtg gac tgg atc cac agc aac atc tac tgg acc gac tct gtc ctg ggc       1488
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly           
                485                 490                 495               

act gtc tct gtt gcg gat acc aag ggc gtg aag agg aaa acg tta ttc       1536
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe           
            500                 505                 510                   

agg gag aac ggc tcc aag cca agg gcc atc gtg gtg gat cct gtt cat       1584
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His           
        515                 520                 525                       

ggc ttc atg tac tgg act gac tgg gga act ccc gcc aag atc aag aaa       1632
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys           
    530                 535                 540                           

ggg ggc ctg aat ggt gtg gac atc tac tcg ctg gtg act gaa aac att       1680
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile           
545                 550                 555                 560           

cag tgg ccc aat ggc atc acc cta gat ctc ctc agt ggc cgc ctc tac       1728
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr           
                565                 570                 575               

tgg gtt gac tcc aaa ctt cac tcc atc tca agc atc gat gtc aat ggg       1776
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly           
            580                 585                 590                   

ggc aac cgg aag acc atc ttg gag gat gaa aag agg ctg gcc cac ccc       1824
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro           
        595                 600                 605                       

ttc tcc ttg gcc gtc ttt gag gac aaa gta ttt tgg aca gat atc atc       1872
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile           
    610                 615                 620                           

aac gaa gcc att ttc agt gcc aac cgc ctc aca ggt tcc gat gtc aac       1920
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn           
625                 630                 635                 640           

ttg ttg gct gaa aac cta ctg tcc cca gag gat atg gtc ctc ttc cac       1968
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His           
                645                 650                 655               

aac ctc acc cag cca aga gga gtg aac tgg tgt gag agg acc acc ctg       2016
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu           
            660                 665                 670                   

agc aat ggc ggc tgc cag tat ctg tgc ctc cct gcc ccg cag atc aac       2064
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn           
        675                 680                 685                       

ccc cac tcg ccc aag ttt acc tgc gcc tgc ccg gac ggc atg ctg ctg       2112
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu           
    690                 695                 700                           

gcc agg gac atg agg agc tgc ctc aca gag gct gag gct gca gtg gcc       2160
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala           
705                 710                 715                 720           

acc cag gag aca tcc acc gtc agg cta aag gtc agc tcc aca gcc gta       2208
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val           
                725                 730                 735               

agg aca cag cac aca acc acc cgg cct gtt ccc gac acc tcc cgg ctg       2256
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu           
            740                 745                 750                   

cct ggg gcc acc cct ggg ctc acc acg gtg gag ata gtg aca atg tct       2304
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser           
        755                 760                 765                       

cac caa gct ctg ggc gac gtt gct ggc aga gga aat gag aag aag ccc       2352
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro           
    770                 775                 780                           

agt agc gtg agg gct ctg tcc att gtc ctc ccc atc gtg ctc ctc gtc       2400
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val           
785                 790                 795                 800           

ttc ctt tgc ctg ggg gtc ttc ctt cta tgg aag aac tgg cgg ctt aag       2448
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys           
                805                 810                 815               

aac atc aac agc atc aac ttt gac aac ccc gtc tat cag aag acc aca       2496
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr           
            820                 825                 830                   

gag gat gag gtc cac att tgc cac aac cag gac ggc tac agc tac ccc       2544
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro           
        835                 840                 845                       

tcg aga cag atg gtc agt ctg gag gat gac gtg gcg tag                   2583
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala                           
    850                 855                 860                           


<210>  3
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  4
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial hLDLR


<220>
<221>  misc_feature
<222>  (1)..(2583)
<223>  Artificial hLDLR coding sequence

<400>  4
atgggacctt ggggttggaa actccgctgg acagtggctc tgctcctggc agcagcagga       60

acagccgtgg gagatcgctg cgaaaggaac gagttccagt gccaggacgg caagtgcatc      120

agctacaagt gggtctgcga cggtagcgca gagtgtcagg acggaagcga cgaaagccag      180

gagacttgcc tgagcgtgac ttgcaagtcc ggcgacttct cttgcggagg cagagtgaac      240

cgctgcatcc ctcagttttg gcggtgcgac ggccaggtgg attgcgataa cggaagcgac      300

gagcagggtt gccctcctaa gacttgcagc caggacgaat tccgctgtca cgacggcaag      360

tgcatcagca ggcagttcgt ctgcgacagc gacagggatt gtctggacgg aagcgacgag      420

gcctcttgtc ctgtgctgac ttgtggccca gccagcttcc agtgcaactc cagcacttgc      480

atcccacagc tctgggcttg cgacaacgac ccagattgcg aggacggatc agacgagtgg      540

ccacagcgct gcagaggcct gtacgtgttt cagggcgatt ccagcccttg cagcgctttt      600

gagttccact gcctgagcgg cgagtgcatt cactcttctt ggaggtgcga cggtggccca      660

gattgcaagg acaagagcga cgaggagaat tgcgccgtgg ctacttgcag accagacgaa      720

ttccagtgca gcgacggcaa ttgcatccac ggctctaggc agtgcgacag ggagtacgat      780

tgcaaggaca tgagcgacga agtcggttgc gtgaacgtca ccctctgcga gggtcccaat      840

aagttcaagt gccacagcgg cgagtgcatt accctggaca aggtctgcaa catggccagg      900

gattgccggg attggagcga cgagcctatc aaggagtgcg gcaccaacga gtgcctggat      960

aacaacggcg gctgcagcca cgtgtgcaat gacctgaaga tcggctacga gtgcctctgc     1020

ccagacggat tccagctggt ggctcagaga cgctgcgaag acatcgacga gtgccaggat     1080

cccgacactt gcagccagct gtgcgtgaat ctggagggag gctacaagtg ccagtgcgaa     1140

gagggattcc agctggaccc tcacaccaag gcttgtaaag ccgtgggcag catcgcctac     1200

ctgttcttca ccaacagaca cgaagtgcgg aagatgaccc tggatcggag cgagtacacc     1260

agcctgatcc ctaacctgcg gaacgtggtg gccctggata cagaagtggc cagcaacagg     1320

atctattgga gcgacctgag ccagcggatg atttgcagca cccagctgga cagagcccac     1380

ggagtgtcca gctacgacac cgtgatcagc agagacatcc aggctccaga cggactggca     1440

gtggattgga tccacagcaa catctactgg accgactcag tgctgggaac agtgtccgtg     1500

gccgatacaa agggcgtgaa gcggaagacc ctgttcagag agaacggcag caagcccagg     1560

gctattgtgg tggatcccgt gcacggcttc atgtattgga ccgattgggg cacccccgct     1620

aagatcaaga agggcggcct gaacggcgtg gacatctaca gcctggtgac cgagaacatc     1680

cagtggccca acggaattac cctggacctg ctgagcggca gactgtattg ggtggacagc     1740

aagctgcaca gcatcagcag catcgacgtg aacggcggaa accggaagac catcctggag     1800

gacgagaaga gactggccca ccctttcagc ctggccgtgt tcgaggacaa ggtcttctgg     1860

accgacatca tcaacgaggc catcttcagc gccaacaggc tgacaggaag cgacgtgaac     1920

ctgctggcag agaatctgct gtctcccgag gacatggtgc tgttccacaa cctgacccag     1980

cccagaggcg tcaattggtg cgagagaacc accctgagca acggaggttg ccagtacctg     2040

tgcctgccag cccctcagat taaccctcac agccccaagt tcacttgcgc ttgcccagac     2100

ggcatgctgc tggccagaga tatgcggtct tgtctgacag aagccgaagc cgctgtggct     2160

acacaggaga caagcaccgt gcggctgaag gtgtctagca cagccgtgag aacccagcac     2220

acaaccacca gacccgtgcc agataccagc agactgccag gagctacacc aggactgacc     2280

accgtggaga tcgtgaccat gagccaccag gctctgggag acgtggcagg aagaggaaac     2340

gagaagaagc ctagcagcgt gagagccctg tctatcgtgc tgcccatcgt gctgctggtg     2400

ttcctctgtc tgggcgtgtt cctcctctgg aagaattggc ggctgaagaa catcaacagc     2460

atcaacttcg acaaccccgt gtaccagaag accaccgagg acgaggtgca catttgccac     2520

aaccaggacg gctacagcta ccctagcagg cagatggtgt ccctggaaga cgacgtggct     2580

tga                                                                   2583


<210>  5
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adeno-associated virus 8 vp1 capsid protein

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  6
<211>  6768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV.TBG.PI.hLDLRco.RGB


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  enhancer
<222>  (221)..(320)
<223>  Alpha mic/bik

<220>
<221>  enhancer
<222>  (327)..(426)
<223>  Alpha mic/bik

<220>
<221>  promoter
<222>  (442)..(901)
<223>  TBG

<220>
<221>  TATA_signal
<222>  (885)..(888)
<223>  TATA

<220>
<221>  CDS
<222>  (969)..(3551)
<223>  codon optimized hLDLR

<220>
<221>  polyA_signal
<222>  (3603)..(3729)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (3818)..(3947)
<223>  3' ITR

<220>
<221>  rep_origin
<222>  (4124)..(4579)
<223>  f1 ori

<220>
<221>  misc_feature
<222>  (4710)..(5567)
<223>  AP(R)

<220>
<221>  rep_origin
<222>  (5741)..(6329)
<223>  Origin of replication

<400>  6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttaagctagc aggttaattt ttaaaaagca      240

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      300

ctcaggagca caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag      360

tggcccttgg cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa      420

cattccagat ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat      480

gcatgtataa tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa      540

ctttccctta aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc      600

tgctgcctct tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc      660

agcatggact taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag      720

ggtctggcag ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct      780

cttggccttg gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt      840

aatttataac taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga      900

tgttgctttc tgagagacag ctttattgcg gtagtttatc acagttaaat tgctaacgca      960

gacgttgc atg gga cct tgg ggt tgg aaa ctc cgc tgg aca gtg gct ctg      1010
         Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu          
         1               5                   10                           

ctc ctg gca gca gca gga aca gcc gtg gga gat cgc tgc gaa agg aac       1058
Leu Leu Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn           
15                  20                  25                  30            

gag ttc cag tgc cag gac ggc aag tgc atc agc tac aag tgg gtc tgc       1106
Glu Phe Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys           
                35                  40                  45                

gac ggt agc gca gag tgt cag gac gga agc gac gaa agc cag gag act       1154
Asp Gly Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr           
            50                  55                  60                    

tgc ctg agc gtg act tgc aag tcc ggc gac ttc tct tgc gga ggc aga       1202
Cys Leu Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg           
        65                  70                  75                        

gtg aac cgc tgc atc cct cag ttt tgg cgg tgc gac ggc cag gtg gat       1250
Val Asn Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp           
    80                  85                  90                            

tgc gat aac gga agc gac gag cag ggt tgc cct cct aag act tgc agc       1298
Cys Asp Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser           
95                  100                 105                 110           

cag gac gaa ttc cgc tgt cac gac ggc aag tgc atc agc agg cag ttc       1346
Gln Asp Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe           
                115                 120                 125               

gtc tgc gac agc gac agg gat tgt ctg gac gga agc gac gag gcc tct       1394
Val Cys Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser           
            130                 135                 140                   

tgt cct gtg ctg act tgt ggc cca gcc agc ttc cag tgc aac tcc agc       1442
Cys Pro Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser           
        145                 150                 155                       

act tgc atc cca cag ctc tgg gct tgc gac aac gac cca gat tgc gag       1490
Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu           
    160                 165                 170                           

gac gga tca gac gag tgg cca cag cgc tgc aga ggc ctg tac gtg ttt       1538
Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe           
175                 180                 185                 190           

cag ggc gat tcc agc cct tgc agc gct ttt gag ttc cac tgc ctg agc       1586
Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser           
                195                 200                 205               

ggc gag tgc att cac tct tct tgg agg tgc gac ggt ggc cca gat tgc       1634
Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys           
            210                 215                 220                   

aag gac aag agc gac gag gag aat tgc gcc gtg gct act tgc aga cca       1682
Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro           
        225                 230                 235                       

gac gaa ttc cag tgc agc gac ggc aat tgc atc cac ggc tct agg cag       1730
Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln           
    240                 245                 250                           

tgc gac agg gag tac gat tgc aag gac atg agc gac gaa gtc ggt tgc       1778
Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys           
255                 260                 265                 270           

gtg aac gtc acc ctc tgc gag ggt ccc aat aag ttc aag tgc cac agc       1826
Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser           
                275                 280                 285               

ggc gag tgc att acc ctg gac aag gtc tgc aac atg gcc agg gat tgc       1874
Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys           
            290                 295                 300                   

cgg gat tgg agc gac gag cct atc aag gag tgc ggc acc aac gag tgc       1922
Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys           
        305                 310                 315                       

ctg gat aac aac ggc ggc tgc agc cac gtg tgc aat gac ctg aag atc       1970
Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile           
    320                 325                 330                           

ggc tac gag tgc ctc tgc cca gac gga ttc cag ctg gtg gct cag aga       2018
Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg           
335                 340                 345                 350           

cgc tgc gaa gac atc gac gag tgc cag gat ccc gac act tgc agc cag       2066
Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln           
                355                 360                 365               

ctg tgc gtg aat ctg gag gga ggc tac aag tgc cag tgc gaa gag gga       2114
Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly           
            370                 375                 380                   

ttc cag ctg gac cct cac acc aag gct tgt aaa gcc gtg ggc agc atc       2162
Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile           
        385                 390                 395                       

gcc tac ctg ttc ttc acc aac aga cac gaa gtg cgg aag atg acc ctg       2210
Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu           
    400                 405                 410                           

gat cgg agc gag tac acc agc ctg atc cct aac ctg cgg aac gtg gtg       2258
Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val           
415                 420                 425                 430           

gcc ctg gat aca gaa gtg gcc agc aac agg atc tat tgg agc gac ctg       2306
Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu           
                435                 440                 445               

agc cag cgg atg att tgc agc acc cag ctg gac aga gcc cac gga gtg       2354
Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val           
            450                 455                 460                   

tcc agc tac gac acc gtg atc agc aga gac atc cag gct cca gac gga       2402
Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly           
        465                 470                 475                       

ctg gca gtg gat tgg atc cac agc aac atc tac tgg acc gac tca gtg       2450
Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val           
    480                 485                 490                           

ctg gga aca gtg tcc gtg gcc gat aca aag ggc gtg aag cgg aag acc       2498
Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr           
495                 500                 505                 510           

ctg ttc aga gag aac ggc agc aag ccc agg gct att gtg gtg gat ccc       2546
Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro           
                515                 520                 525               

gtg cac ggc ttc atg tat tgg acc gat tgg ggc acc ccc gct aag atc       2594
Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile           
            530                 535                 540                   

aag aag ggc ggc ctg aac ggc gtg gac atc tac agc ctg gtg acc gag       2642
Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu           
        545                 550                 555                       

aac atc cag tgg ccc aac gga att acc ctg gac ctg ctg agc ggc aga       2690
Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg           
    560                 565                 570                           

ctg tat tgg gtg gac agc aag ctg cac agc atc agc agc atc gac gtg       2738
Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val           
575                 580                 585                 590           

aac ggc gga aac cgg aag acc atc ctg gag gac gag aag aga ctg gcc       2786
Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala           
                595                 600                 605               

cac cct ttc agc ctg gcc gtg ttc gag gac aag gtc ttc tgg acc gac       2834
His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp           
            610                 615                 620                   

atc atc aac gag gcc atc ttc agc gcc aac agg ctg aca gga agc gac       2882
Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp           
        625                 630                 635                       

gtg aac ctg ctg gca gag aat ctg ctg tct ccc gag gac atg gtg ctg       2930
Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu           
    640                 645                 650                           

ttc cac aac ctg acc cag ccc aga ggc gtc aat tgg tgc gag aga acc       2978
Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr           
655                 660                 665                 670           

acc ctg agc aac gga ggt tgc cag tac ctg tgc ctg cca gcc cct cag       3026
Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln           
                675                 680                 685               

att aac cct cac agc ccc aag ttc act tgc gct tgc cca gac ggc atg       3074
Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met           
            690                 695                 700                   

ctg ctg gcc aga gat atg cgg tct tgt ctg aca gaa gcc gaa gcc gct       3122
Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala           
        705                 710                 715                       

gtg gct aca cag gag aca agc acc gtg cgg ctg aag gtg tct agc aca       3170
Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr           
    720                 725                 730                           

gcc gtg aga acc cag cac aca acc acc aga ccc gtg cca gat acc agc       3218
Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser           
735                 740                 745                 750           

aga ctg cca gga gct aca cca gga ctg acc acc gtg gag atc gtg acc       3266
Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr           
                755                 760                 765               

atg agc cac cag gct ctg gga gac gtg gca gga aga gga aac gag aag       3314
Met Ser His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys           
            770                 775                 780                   

aag cct agc agc gtg aga gcc ctg tct atc gtg ctg ccc atc gtg ctg       3362
Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu           
        785                 790                 795                       

ctg gtg ttc ctc tgt ctg ggc gtg ttc ctc ctc tgg aag aat tgg cgg       3410
Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg           
    800                 805                 810                           

ctg aag aac atc aac agc atc aac ttc gac aac ccc gtg tac cag aag       3458
Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys           
815                 820                 825                 830           

acc acc gag gac gag gtg cac att tgc cac aac cag gac ggc tac agc       3506
Thr Thr Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser           
                835                 840                 845               

tac cct agc agg cag atg gtg tcc ctg gaa gac gac gtg gct tga           3551
Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala                   
            850                 855                 860                   

taagtcgacc cgggcggcct cgaggacggg gtgaactacg cctgaggatc cgatcttttt     3611

ccctctgcca aaaattatgg ggacatcatg aagccccttg agcatctgac ttctggctaa     3671

taaaggaaat ttattttcat tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga     3731

agcaattcgt tgatctgaat ttcgaccacc cataataccc attaccctgg tagataagta     3791

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     3851

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     3911

tgcccgggcg gcctcagtga gcgagcgagc gcgcagcctt aattaaccta attcactggc     3971

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc     4031

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     4091

ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc     4151

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     4211

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     4271

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     4331

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     4391

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     4451

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     4511

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct     4571

tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     4631

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     4691

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     4751

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     4811

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc     4871

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta     4931

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac     4991

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc     5051

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac     5111

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg     5171

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac     5231

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc     5291

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt     5351

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga     5411

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc     5471

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag     5531

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca     5591

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc     5651

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     5711

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     5771

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     5831

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt     5891

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     5951

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     6011

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     6071

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     6131

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     6191

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     6251

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     6311

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     6371

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt     6431

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca     6491

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg     6551

attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac     6611

gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg     6671

gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac     6731

catgattacg ccagatttaa ttaaggcctt aattagg                              6768


<210>  7
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


