                         SEQUENCE LISTING

<110>  Purdue Research Foundation
 
<120>  FUSION PROTEIN AND LIGAND-PAYLOAD BASED DRUG DELIVERY FOR CELL 
       THERAPY

<130>  67762-02

<150>  62/460,118
<151>  2017-02-17

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence for mouse FKBP-FRa with linker peptide

<400>  1

Met Ala His Leu Met Thr Val Gln Leu Leu Leu Leu Val Met Trp Met 
1               5                   10                  15      


Ala Glu Cys Ala Gln Ser Arg Ala Gly Val Gln Val Glu Thr Ile Ser 
            20                  25                  30          


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
        35                  40                  45              


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
    50                  55                  60                  


Asp Arg Asn Lys Pro Phe Lys Phe Thr Leu Gly Lys Gln Glu Val Ile 
65                  70                  75                  80  


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
                85                  90                  95      


Lys Leu Ile Ile Ser Ser Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
            100                 105                 110         


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
        115                 120                 125             


Lys Leu Glu Ser Gly Gly Gly Ser Thr Arg Ala Arg Thr Glu Leu Leu 
    130                 135                 140                 


Asn Val Cys Met Asp Ala Lys His His Lys Glu Lys Pro Gly Pro Glu 
145                 150                 155                 160 


Asp Asn Leu His Asp Gln Cys Ser Pro Trp Lys Thr Asn Ser Cys Cys 
                165                 170                 175     


Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Ile Ser Tyr Leu Tyr 
            180                 185                 190         


Arg Phe Asn Trp Asn His Cys Gly Thr Met Thr Ser Glu Cys Lys Arg 
        195                 200                 205             


His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly 
    210                 215                 220                 


Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Ile Leu 
225                 230                 235                 240 


Asp Val Pro Leu Cys Lys Glu Asp Cys Gln Gln Trp Trp Glu Asp Cys 
                245                 250                 255     


Gln Ser Ser Phe Thr Cys Lys Ser Asn Trp His Lys Gly Trp Asn Trp 
            260                 265                 270         


Ser Ser Gly His Asn Glu Cys Pro Val Gly Ala Ser Cys His Pro Phe 
        275                 280                 285             


Thr Phe Tyr Phe Pro Thr Ser Ala Ala Leu Cys Glu Glu Ile Trp Ser 
    290                 295                 300                 


His Ser Tyr Lys Leu Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile 
305                 310                 315                 320 


Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu Val Ala 
                325                 330                 335     


Arg Phe Tyr Ala Glu Ala Met Ser Gly Ala Gly Phe His Gly Thr Trp 
            340                 345                 350         


Pro Leu Leu Cys Ser Leu Ser Leu Val Leu Leu Trp Val Ile Ser 
        355                 360                 365         


<210>  2
<211>  369
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence for human FKBP-FRa with linker peptide

<400>  2

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Gly Val Gln Val Glu Thr Ile Ser 
            20                  25                  30          


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
        35                  40                  45              


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
    50                  55                  60                  


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
65                  70                  75                  80  


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
                85                  90                  95      


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
            100                 105                 110         


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
        115                 120                 125             


Lys Leu Glu Ser Gly Gly Gly Ser Arg Ile Ala Trp Ala Arg Thr Glu 
    130                 135                 140                 


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
145                 150                 155                 160 


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
                165                 170                 175     


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
            180                 185                 190         


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
        195                 200                 205             


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
    210                 215                 220                 


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
225                 230                 235                 240 


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
                245                 250                 255     


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
            260                 265                 270         


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
        275                 280                 285             


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
    290                 295                 300                 


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
305                 310                 315                 320 


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
                325                 330                 335     


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
            340                 345                 350         


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
        355                 360                 365             


Ser 
    


<210>  3
<211>  485
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence for mouse antiCD19 CAR T construct

<400>  3

Met Gly Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Ala Ile Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Ile 
            20                  25                  30          


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly Glu Thr 
        35                  40                  45              


Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
    50                  55                  60                  


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly 
65                  70                  75                  80  


Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr Glu Asp 
            100                 105                 110         


Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Val 
                165                 170                 175     


Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys Gln Arg 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu Asp Glu 
        195                 200                 205             


Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala 
    210                 215                 220                 


Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu Thr Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr Phe Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Ile Glu Phe Met 
            260                 265                 270         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile 
        275                 280                 285             


His Ile Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro Lys Leu 
    290                 295                 300                 


Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
305                 310                 315                 320 


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn 
                325                 330                 335     


Arg Gly Gly Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
            340                 345                 350         


Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala 
        355                 360                 365             


Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala 
    370                 375                 380                 


Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr 
            420                 425                 430         


Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Thr Leu Ala Pro Arg 
                485 


<210>  4
<211>  496
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence for human antiCD19 CAR T construct

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
        275                 280                 285             


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
    290                 295                 300                 


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  5
<211>  12182
<212>  DNA
<213>  artificial

<220>
<223>  Vector sequence for pWPI for human T cell transduction

<400>  5
ttggaagggc taattcactc ccaaagaaga caagatatcc ttgatctgtg gatctaccac       60

acacaaggct acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca      120

ctgacctttg gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc      180

aataaaggag agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg      240

gagagagaag tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga      300

gagctgcatc cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc      360

gctggggact ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga      420

tcctgcatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      480

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc      540

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct      600

cagacccttt tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa      660

gcgaaaggga aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg      720

gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag      780

aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg      840

gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg      900

gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc      960

tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga     1020

tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac     1080

accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag     1140

caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     1200

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     1260

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     1320

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     1380

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     1440

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     1500

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     1560

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     1620

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat     1680

acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga     1740

attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat     1800

aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact     1860

ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc     1920

aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag     1980

agacagatcc attcgattag tgaacggatc tcgacggtat cgatgtcgac gataagcttt     2040

gcaaagatgg ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt     2100

cttgaaagga gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     2160

agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg     2220

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     2280

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     2340

cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg     2400

cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt     2460

cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt     2520

gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt     2580

cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct     2640

gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt     2700

atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg     2760

gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc     2820

cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg     2880

ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca     2940

gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa     3000

aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg     3060

ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg     3120

gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca     3180

gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc     3240

attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt gtcgtgagga     3300

atttcgacat ttaaatttaa ttaatctcga cggtatcggt taacttttaa aagaaaaggg     3360

gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa     3420

actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatca cgagactagc     3480

ctcgaggttt atggctcacc tgatgactgt gcagttgttg ctcctggtga tgtggatggc     3540

cgaatgtgct cagtccagag ctggagtgca ggtggagacc atctctcctg gagacgggcg     3600

caccttccca aagcgcggcc agacctgcgt ggtgcactac acggggatgc ttgaagatgg     3660

aaagaaattt gattcctctc gggacagaaa caagcctttt aagtttacac taggcaagca     3720

ggaggtgatc cgaggctggg aggaaggggt agcccagatg agtgtgggtc agagagccaa     3780

actgataatc tcctcagact atgcctatgg agccaccggg cacccaggca tcatcccacc     3840

acatgccact cttgtttttg atgtggagct tctaaaactg gaaagcggcg gcggcagcac     3900

tcgggccagg actgaacttc tcaatgtctg catggatgcc aaacaccaca aagaaaaacc     3960

gggccctgag gacaatttac acgaccagtg cagcccctgg aagacgaatt cctgctgttc     4020

cacgaacaca agccaggaag cacataagga catttcctac ctgtaccggt tcaactggaa     4080

ccactgcgga actatgacat cggaatgcaa acggcacttt atccaagaca cctgcctcta     4140

tgagtgttcc ccgaacttgg gaccctggat ccagcaggtg gaccagagct ggcgcaaaga     4200

gcggatcctt gatgttcccc tgtgcaaaga ggactgtcag cagtggtggg aggactgcca     4260

gagctctttt acctgcaaga gcaattggca caagggatgg aactggtcct cggggcataa     4320

cgagtgtcct gtgggagcct cctgccatcc cttcaccttc tacttcccca catctgctgc     4380

tctgtgtgag gaaatctgga gtcactccta caagctcagc aactacagtc gagggagcgg     4440

ccgctgcatt cagatgtggt tcgacccagc ccagggcaac cccaacgagg aagtggcgag     4500

gttctatgcc gaggccatga gtggagctgg gtttcatggg acctggccac tcttgtgcag     4560

cctgtcctta gtgctgctct gggtgatcag ctgaaaacta cgggctgcag gaattccgcc     4620

cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct     4680

atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc     4740

ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc     4800

tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg     4860

tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa     4920

agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt     4980

ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg     5040

atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta     5100

catgtgttta gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt     5160

cctttgaaaa acacgatgat aataccatgg tgagcaaggg cgaggagctg ttcaccgggg     5220

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     5280

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     5340

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     5400

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     5460

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     5520

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     5580

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     5640

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     5700

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     5760

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     5820

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     5880

tcggcatgga cgagctgtac aagtccggac tcagatctcg actagctagt agctagctag     5940

ctagtcgagc tcaagcttcg aattcgatat caagcttatc gcgataccgt cgacctcgag     6000

ggaattccga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     6060

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     6120

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     6180

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     6240

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     6300

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     6360

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc     6420

catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     6480

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     6540

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     6600

atcgggaatt cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt     6660

agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa     6720

gatgggatca attcaccatg ggaataactt cgtatagcat acattatacg aagttatgct     6780

gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     6840

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     6900

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     6960

gtggaaaatc tctagcagca tctagaatta attccgtgta ttctatagtg tcacctaaat     7020

cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa cgacaatatg     7080

tacaagccta attgtgtagc atctggctta ctgaagcaga ccctatcatc tctctcgtaa     7140

actgccgtca gagtcggttt ggttggacga accttctgag tttctggtaa cgccgtcccg     7200

cacccggaaa tggtcagcga accaatcagc agggtcatcg ctagccagat cctctacgcc     7260

ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc     7320

gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc     7380

gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc cttgcatgca     7440

ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg cttcctaatg     7500

caggagtcgc ataagggaga gcgtcgaatg gtgcactctc agtacaatct gctctgatgc     7560

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     7620

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     7680

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt     7740

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     7800

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     7860

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     7920

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     7980

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     8040

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     8100

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     8160

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     8220

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     8280

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     8340

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     8400

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     8460

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     8520

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     8580

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     8640

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     8700

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     8760

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     8820

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     8880

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     8940

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     9000

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     9060

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     9120

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     9180

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     9240

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     9300

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     9360

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     9420

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     9480

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     9540

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     9600

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     9660

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     9720

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct gtggaatgtg     9780

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     9840

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     9900

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     9960

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt    10020

atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc    10080

ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt gcgagatatg    10140

tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag acgcggactc    10200

atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac ctattttccc    10260

ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga gcgaaaaata    10320

catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc gactgatgcc    10380

ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc gggtgcgtta    10440

ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag ctacgatcac    10500

gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga aggcttcatc    10560

gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga aatgtatcca    10620

aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt tgatgactat    10680

gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg cgtcgtattc    10740

gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg cgttgttctt    10800

tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg catccatgac    10860

acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg aaacctcgac    10920

gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc ttgatggtaa    10980

aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc gcggcattga    11040

cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg aacgtaccga    11100

cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt atgagtgggc    11160

cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac aaactaccta    11220

cagagattta aagctctaag gtaaatataa aatttttaag tgtataatgt gttaaactac    11280

tgattctaat tgtttgtgta ttttagattc caacctatgg aactgatgaa tgggagcagt    11340

ggtggaatgc ctttaatgag gaaaacctgt tttgctcaga agaaatgcca tctagtgatg    11400

atgaggctac tgctgactct caacattcta ctcctccaaa aaagaagaga aaggtagaag    11460

accccaagga ctttccttca gaattgctaa gttttttgag tcatgctgtg tttagtaata    11520

gaactcttgc ttgctttgct atttacacca caaaggaaaa agctgcactg ctatacaaga    11580

aaattatgga aaaatattct gtaaccttta taagtaggca taacagttat aatcataaca    11640

tactgttttt tcttactcca cacaggcata gagtgtctgc tattaataac tatgctcaaa    11700

aattgtgtac ctttagcttt ttaatttgta aaggggttaa taaggaatat ttgatgtata    11760

gtgccttgac tagagatcat aatcagccat accacatttg tagaggtttt acttgcttta    11820

aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt    11880

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca    11940

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    12000

tatcatgtct ggatcaactg gataactcaa gctaaccaaa atcatcccaa acttcccacc    12060

ccatacccta ttaccactgc caattaccta gtggtttcat ttactctaaa cctgtgattc    12120

ctctgaatta ttttcatttt aaagaaattg tatttgttaa atatgtacta caaacttagt    12180

ag                                                                   12182


<210>  6
<211>  6939
<212>  DNA
<213>  artificial

<220>
<223>  pMP71 gb NotIEcoRI mouse antiCD19 for mouse T cell transduction

<400>  6
tcaaggttag gaacagagag acaggagaat atgggccaaa caggatatct gtggtaagca       60

gttcctgccc cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga      120

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc      180

ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc      240

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc      300

gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg cgcgccagtc      360

ctccgattga ctgcgtcgcc cgggtacccg tattcccaat aaagcctctt gctgtttgca      420

tccgaatcgt ggactcgctg atccttggga gggtctcctc agattgattg actgcccacc      480

tcgggggtct ttcatttgga ggttccaccg agatttggag acccctgccc agggaccacc      540

gacccccccg ccgggaggta agctggccag cggtcgtttc gtgtctgtct ctgtctttgg      600

gcgtgtttgt gccggcatct aatgtttgcg cctgcgtctg tactagttgg ctaactagat      660

ctgtatctgg cggtcccgcg gaagaactga cgagttcgta ttcccggccg cagcccctgg      720

gagacgtccc agcggcctcg ggggcccgtt ttgtggccca ttctgtatca gttaacctac      780

ccgagtcgga ctttttggag ctccgccact gtccgagggg tacgtggctt tgttggggga      840

cgagagacag agacacttcc cgcccccgtc tgaatttttg ctttcggttt tacgccgaaa      900

ccgcgccgcg cgtcttgtct gctgcagcat cgttctgtgt tgtctctgtc tgactgtgtt      960

tctgtatttg tctgaaaatt agctcgacaa agttaagtaa tagtccctct ctccaagctc     1020

acttacaggc atgggggttc ccacccagct gttggggttg ctgctcctct ggatcactga     1080

tgccatctgc gaacagaagc tcatttctga agaagatctg gacatacaga tgacccagag     1140

tcctgccagc ttgtccacat ccctcggaga gaccgtgaca attcaatgcc aggcctctga     1200

ggacatatat tctggattgg cttggtacca gcaaaagcca ggtaaaagtc ctcagttgtt     1260

gatatacggc gcttctgatt tgcaagacgg ggtgccctca cgatttagcg ggtctggaag     1320

tggcactcag tacagtctga agattacttc aatgcaaaca gaagacgagg gtgtgtattt     1380

ttgccaacag gggctgacct acccaaggac attcgggggc ggtacaaagc ttgaacttaa     1440

gggcggcggt gggtctggag gtggtggatc tggcggaggg ggaagtgagg tacagctgca     1500

acagtccggc gccgaactcg ttcgccctgg aacctcagtc aaattgtcat gcaaggtgag     1560

tggcgacaca ataacctttt actatatgca cttcgttaaa cagaggccag gtcaaggtct     1620

ggaatggata ggcagaattg atccagaaga tgagtccacc aaatactcag aaaagttcaa     1680

aaacaaagcc actcttactg ccgacacctc aagcaacaca gcatatctta agctcagttc     1740

acttaccagc gaagacaccg ccacctattt ttgtatttat ggtggctatt actttgacta     1800

ctgggggcaa ggtgttatgg taacagtttc ttccattgaa ttcatgtatc caccccccta     1860

tttggataat gaacgatcta atgggactat aatacatatc aaggaaaagc atctgtgtca     1920

tacccaaagt tcccctaagc ttttctgggc cctcgtcgtt gtggcaggag tgcttttttg     1980

ctatggattg ttggttactg tggctctctg cgtcatttgg acaaatagta ggaggaatcg     2040

ggggggacaa tctgattaca tgaacatgac accacggagg ccaggcctta ccagaaagcc     2100

ctaccaacct tatgcaccag cacgagactt cgccgcatac aggccaaggg ctaagttttc     2160

ccgcagcgcc gaaaccgcag ccaacctcca agatcctaat cagctctata acgaattgaa     2220

tcttggccgc agagaggagt acgacgtact tgagaaaaag agagctaggg accctgaaat     2280

gggtgggaag caacagcgaa gaaggaaccc acaggaaggg gtgtataatg cccttcaaaa     2340

ggataaaatg gcagaggcat acagtgaaat cggaaccaag ggggagagac gcagagggaa     2400

aggccatgac ggcctttatc agggtttgtc aactgctact aaagacactt atgatgcctt     2460

gcatatgcaa actctcgcac ccagatgacg agcatcttac cgccatttat tcccatattt     2520

gttctgtttt tcttgatttg ggtatacatt taaatgttaa taaaacaaaa tggtggggca     2580

atcatttaca ttttatggga tatgtaatta ctagttcagg tgtattgcca caagacaaac     2640

atgttaagaa actttcccgt tatttacgct ctgttcctgt taatcaacct ctggattaca     2700

aaatttgtga aagattgact gatattctta actatgttgc tccttttacg ctgtgtggat     2760

atgctgcttt aatgcctctg tatcatgcta ttgcttcccg tacggctttc gttttctcct     2820

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtccgtcaac     2880

gtggcgtggt gtgctctgtg tttgctgacg caacccccac tggctggggc attgccacca     2940

cctgtcaact cctttctggg actttcgctt tccccctccc gatcgccacg gcagaactca     3000

tcgccgcctg ccttgcccgc tgctggacag gggctaggtt gctgggcact gataattccg     3060

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccaactgga     3120

tcctgcgcgg gacgtccttc tgctacgtcc cttcggctct caatccagcg gacctccctt     3180

cccgaggcct tctgccggtt ctgcggcctc tcccgcgtct tcgctttcgg cctccgacga     3240

gtcggatctc cctttgggcc gcctccccgc ctgtttcgcc tcggcgtccg gtccgtgttg     3300

cttggtcgtc acctgtgcag aattgcgaac catggattcc accgtgaact ttgtctcctg     3360

gcatgcaaat cgtcaacttg gcatgccaag aattaattcg gatccaagct taggcctgct     3420

cgctttcttg ctgtcccatt tctattaaag gttcctttgt tccctaagtc caactactaa     3480

actgggggat attatgaagg gccttgagca tctggattct gcctagcgct aagcttccta     3540

acacgagcca tagatagaat aaaagatttt atttagtctc cagaaaaagg ggggaatgaa     3600

agaccccacc tgtaggtttg gcaagctagc ttaagtaagc cattttgcaa ggcatggaaa     3660

aatacataac tgagaataga gaagttcaga tcaaggttag gaacagagag acaggagaat     3720

atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag     3780

ttggaacagc agaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct     3840

cagggccaag aacagatggt ccccagatgc ggtcccgccc tcagcagttt ctagagaacc     3900

atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa     3960

ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga     4020

gcccacaacc cctcactcgg cgcgccagtc ctccgataga ctgcgtcgcc cggggtaccc     4080

gtattcccaa taaagcctct tgctgtttgc atccgaatcg tggactcgct gatccttggg     4140

agggtctcct cagattgatt gactgcccac ctcgggggtc tttcattctc gagagctttg     4200

gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac     4260

aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc     4320

acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg     4380

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     4440

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     4500

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     4560

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     4620

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     4680

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     4740

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     4800

ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     4860

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     4920

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     4980

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     5040

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     5100

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     5160

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     5220

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     5280

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5340

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5400

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5460

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5520

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5580

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     5640

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctgc tggcatcgtg     5700

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     5760

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     5820

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     5880

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     5940

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     6000

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     6060

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     6120

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     6180

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     6240

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6300

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6360

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     6420

aggccctttc gtcttcaagc tgcctcgcgc gtttcggtga tgacggtgaa aacctctgac     6480

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     6540

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg cgcagccatg acccagtcac     6600

gtagcgatag ttactatgcg gcatcagagc agattgtact gagagtgcac catatgcggt     6660

gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggcgccat tcgccattca     6720

ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccagctgg     6780

cgaaaggggg atgtgctgca aggcgattaa gttgggtaac gccagggttt tcccagtcac     6840

gacgttgtaa aacgacggcc agtgaattag tactctagct taagtaagcc attttgcaag     6900

gcatggaaaa atacataact gagaatagag aagttcaga                            6939


<210>  7
<211>  12188
<212>  DNA
<213>  artificial

<220>
<223>  pWPI-FRa 1-24 FKBP FRa

<400>  7
ttggaagggc taattcactc ccaaagaaga caagatatcc ttgatctgtg gatctaccac       60

acacaaggct acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca      120

ctgacctttg gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc      180

aataaaggag agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg      240

gagagagaag tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga      300

gagctgcatc cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc      360

gctggggact ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga      420

tcctgcatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      480

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc      540

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct      600

cagacccttt tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa      660

gcgaaaggga aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg      720

gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag      780

aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg      840

gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg      900

gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc      960

tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga     1020

tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac     1080

accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag     1140

caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     1200

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     1260

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     1320

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     1380

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     1440

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     1500

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     1560

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     1620

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat     1680

acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga     1740

attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat     1800

aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact     1860

ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc     1920

aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag     1980

agacagatcc attcgattag tgaacggatc tcgacggtat cgatgtcgac gataagcttt     2040

gcaaagatgg ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt     2100

cttgaaagga gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     2160

agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg     2220

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     2280

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     2340

cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg     2400

cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt     2460

cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt     2520

gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt     2580

cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct     2640

gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt     2700

atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg     2760

gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc     2820

cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg     2880

ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca     2940

gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa     3000

aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg     3060

ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg     3120

gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca     3180

gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc     3240

attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt gtcgtgagga     3300

atttcgacat ttaaatttaa ttaatctcga cggtatcggt taacttttaa aagaaaaggg     3360

gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa     3420

actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatca cgagactagc     3480

ctcgaggttt atggctcagc ggatgacaac acagctgctg ctccttctag tgtgggtggc     3540

tgtagtaggg gaggctcaga caggagtgca ggtggagact atctccccag gagacgggcg     3600

caccttcccc aagcgcggcc agacctgcgt ggtgcactac accgggatgc ttgaagatgg     3660

aaagaaattt gattcctccc gggacagaaa caagcccttt aagtttatgc taggcaagca     3720

ggaggtgatc cgaggctggg aagaaggggt tgcccagatg agtgtgggtc agagagccaa     3780

actgactata tctccagatt atgcctatgg tgccactggg cacccaggca tcatcccacc     3840

acatgccact ctcgtcttcg atgtggagct tctaaaactg gaatctggcg gtggatccag     3900

gattgcatgg gccaggactg agcttctcaa tgtctgcatg aacgccaagc accacaagga     3960

aaagccaggc cccgaggaca agttgcatga gcagtgtcga ccctggagga agaatgcctg     4020

ctgttctacc aacaccagcc aggaagccca taaggatgtt tcctacctat atagattcaa     4080

ctggaaccac tgtggagaga tggcacctgc ctgcaaacgg catttcatcc aggacacctg     4140

cctctacgag tgctccccca acttggggcc ctggatccag caggtggatc agagctggcg     4200

caaagagcgg gtactgaacg tgcccctgtg caaagaggac tgtgagcaat ggtgggaaga     4260

ttgtcgcacc tcctacacct gcaagagcaa ctggcacaag ggctggaact ggacttcagg     4320

gtttaacaag tgcgcagtgg gagctgcctg ccaacctttc catttctact tccccacacc     4380

cactgttctg tgcaatgaaa tctggactca ctcctacaag gtcagcaact acagccgagg     4440

gagtggccgc tgcatccaga tgtggttcga cccagcccag ggcaacccca atgaggaggt     4500

ggcgaggttc tatgctgcag ccatgagtgg ggctgggccc tgggcagcct ggcctttcct     4560

gcttagcctg gccctaatgc tgctgtggct gctcagctga aaactacggg ctgcaggaat     4620

tccgcccccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt     4680

ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac     4740

ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc     4800

aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa     4860

cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg     4920

gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg     4980

tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc     5040

tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat     5100

gctttacatg tgtttagtcg aggttaaaaa acgtctaggc cccccgaacc acggggacgt     5160

ggttttcctt tgaaaaacac gatgataata ccatggtgag caagggcgag gagctgttca     5220

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     5280

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     5340

ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc     5400

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     5460

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     5520

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     5580

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     5640

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     5700

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     5760

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca     5820

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     5880

tcactctcgg catggacgag ctgtacaagt ccggactcag atctcgacta gctagtagct     5940

agctagctag tcgagctcaa gcttcgaatt cgatatcaag cttatcgcga taccgtcgac     6000

ctcgagggaa ttccgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     6060

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     6120

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     6180

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     6240

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     6300

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     6360

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt     6420

cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     6480

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     6540

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     6600

ccccgcatcg ggaattcgag ctcggtacct ttaagaccaa tgacttacaa ggcagctgta     6660

gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca ctcccaacga     6720

agacaagatg ggatcaattc accatgggaa taacttcgta tagcatacat tatacgaagt     6780

tatgctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct     6840

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca     6900

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta     6960

gtcagtgtgg aaaatctcta gcagcatcta gaattaattc cgtgtattct atagtgtcac     7020

ctaaatcgta tgtgtatgat acataaggtt atgtattaat tgtagccgcg ttctaacgac     7080

aatatgtaca agcctaattg tgtagcatct ggcttactga agcagaccct atcatctctc     7140

tcgtaaactg ccgtcagagt cggtttggtt ggacgaacct tctgagtttc tggtaacgcc     7200

gtcccgcacc cggaaatggt cagcgaacca atcagcaggg tcatcgctag ccagatcctc     7260

tacgccggac gcatcgtggc cggcatcacc ggcgccacag gtgcggttgc tggcgcctat     7320

atcgccgaca tcaccgatgg ggaagatcgg gctcgccact tcgggctcat gagcgcttgt     7380

ttcggcgtgg gtatggtggc aggccccgtg gccgggggac tgttgggcgc catctccttg     7440

catgcaccat tccttgcggc ggcggtgctc aacggcctca acctactact gggctgcttc     7500

ctaatgcagg agtcgcataa gggagagcgt cgaatggtgc actctcagta caatctgctc     7560

tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg     7620

ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat     7680

gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg     7740

cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt     7800

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta     7860

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat     7920

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt     7980

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg     8040

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga     8100

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg     8160

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt     8220

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     8280

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     8340

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     8400

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     8460

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     8520

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     8580

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     8640

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     8700

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     8760

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     8820

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     8880

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     8940

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     9000

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     9060

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     9120

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     9180

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     9240

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     9300

gcgaacgacc tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct     9360

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     9420

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     9480

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     9540

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     9600

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     9660

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     9720

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctgtgg     9780

aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     9840

agcatgcatc tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc     9900

agaagtatgc aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg     9960

cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt    10020

ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga    10080

ggaggctttt ttggaggcct aggcttttgc aaaaagcttg gacacaagac aggcttgcga    10140

gatatgtttg agaataccac tttatcccgc gtcagggaga ggcagtgcgt aaaaagacgc    10200

ggactcatgt gaaatactgg tttttagtgc gccagatctc tataatctcg cgcaacctat    10260

tttcccctcg aacacttttt aagccgtaga taaacaggct gggacacttc acatgagcga    10320

aaaatacatc gtcacctggg acatgttgca gatccatgca cgtaaactcg caagccgact    10380

gatgccttct gaacaatgga aaggcattat tgccgtaagc cgtggcggtc tgtaccgggt    10440

gcgttactgg cgcgtgaact gggtattcgt catgtcgata ccgtttgtat ttccagctac    10500

gatcacgaca accagcgcga gcttaaagtg ctgaaacgcg cagaaggcga tggcgaaggc    10560

ttcatcgtta ttgatgacct ggtggatacc ggtggtactg cggttgcgat tcgtgaaatg    10620

tatccaaaag cgcactttgt caccatcttc gcaaaaccgg ctggtcgtcc gctggttgat    10680

gactatgttg ttgatatccc gcaagatacc tggattgaac agccgtggga tatgggcgtc    10740

gtattcgtcc cgccaatctc cggtcgctaa tcttttcaac gcctggcact gccgggcgtt    10800

gttcttttta acttcaggcg ggttacaata gtttccagta agtattctgg aggctgcatc    10860

catgacacag gcaaacctga gcgaaaccct gttcaaaccc cgctttaaac atcctgaaac    10920

ctcgacgcta gtccgccgct ttaatcacgg cgcacaaccg cctgtgcagt cggcccttga    10980

tggtaaaacc atccctcact ggtatcgcat gattaaccgt ctgatgtgga tctggcgcgg    11040

cattgaccca cgcgaaatcc tcgacgtcca ggcacgtatt gtgatgagcg atgccgaacg    11100

taccgacgat gatttatacg atacggtgat tggctaccgt ggcggcaact ggatttatga    11160

gtgggccccg gatctttgtg aaggaacctt acttctgtgg tgtgacataa ttggacaaac    11220

tacctacaga gatttaaagc tctaaggtaa atataaaatt tttaagtgta taatgtgtta    11280

aactactgat tctaattgtt tgtgtatttt agattccaac ctatggaact gatgaatggg    11340

agcagtggtg gaatgccttt aatgaggaaa acctgttttg ctcagaagaa atgccatcta    11400

gtgatgatga ggctactgct gactctcaac attctactcc tccaaaaaag aagagaaagg    11460

tagaagaccc caaggacttt ccttcagaat tgctaagttt tttgagtcat gctgtgttta    11520

gtaatagaac tcttgcttgc tttgctattt acaccacaaa ggaaaaagct gcactgctat    11580

acaagaaaat tatggaaaaa tattctgtaa cctttataag taggcataac agttataatc    11640

ataacatact gttttttctt actccacaca ggcatagagt gtctgctatt aataactatg    11700

ctcaaaaatt gtgtaccttt agctttttaa tttgtaaagg ggttaataag gaatatttga    11760

tgtatagtgc cttgactaga gatcataatc agccatacca catttgtaga ggttttactt    11820

gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt    11880

gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat    11940

ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat    12000

gtatcttatc atgtctggat caactggata actcaagcta accaaaatca tcccaaactt    12060

cccaccccat accctattac cactgccaat tacctagtgg tttcatttac tctaaacctg    12120

tgattcctct gaattatttt cattttaaag aaattgtatt tgttaaatat gtactacaaa    12180

cttagtag                                                             12188


<210>  8
<211>  12182
<212>  DNA
<213>  artificial

<220>
<223>  pWPI mFKBP-mFRa SGGGS

<400>  8
ttggaagggc taattcactc ccaaagaaga caagatatcc ttgatctgtg gatctaccac       60

acacaaggct acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca      120

ctgacctttg gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc      180

aataaaggag agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg      240

gagagagaag tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga      300

gagctgcatc cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc      360

gctggggact ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga      420

tcctgcatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      480

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc      540

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct      600

cagacccttt tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa      660

gcgaaaggga aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg      720

gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag      780

aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg      840

gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg      900

gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc      960

tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga     1020

tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac     1080

accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag     1140

caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     1200

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     1260

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     1320

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     1380

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     1440

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     1500

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     1560

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     1620

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat     1680

acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga     1740

attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat     1800

aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact     1860

ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc     1920

aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag     1980

agacagatcc attcgattag tgaacggatc tcgacggtat cgatgtcgac gataagcttt     2040

gcaaagatgg ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt     2100

cttgaaagga gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     2160

agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg     2220

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     2280

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     2340

cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg     2400

cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt     2460

cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt     2520

gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt     2580

cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct     2640

gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt     2700

atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg     2760

gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc     2820

cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg     2880

ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca     2940

gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa     3000

aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg     3060

ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg     3120

gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca     3180

gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc     3240

attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt gtcgtgagga     3300

atttcgacat ttaaatttaa ttaatctcga cggtatcggt taacttttaa aagaaaaggg     3360

gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa     3420

actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatca cgagactagc     3480

ctcgaggttt atggctcacc tgatgactgt gcagttgttg ctcctggtga tgtggatggc     3540

cgaatgtgct cagtccagag ctggagtgca ggtggagacc atctctcctg gagacgggcg     3600

caccttccca aagcgcggcc agacctgcgt ggtgcactac acggggatgc ttgaagatgg     3660

aaagaaattt gattcctctc gggacagaaa caagcctttt aagtttacac taggcaagca     3720

ggaggtgatc cgaggctggg aggaaggggt agcccagatg agtgtgggtc agagagccaa     3780

actgataatc tcctcagact atgcctatgg agccaccggg cacccaggca tcatcccacc     3840

acatgccact cttgtttttg atgtggagct tctaaaactg gaaagcggcg gcggcagcac     3900

tcgggccagg actgaacttc tcaatgtctg catggatgcc aaacaccaca aagaaaaacc     3960

gggccctgag gacaatttac acgaccagtg cagcccctgg aagacgaatt cctgctgttc     4020

cacgaacaca agccaggaag cacataagga catttcctac ctgtaccggt tcaactggaa     4080

ccactgcgga actatgacat cggaatgcaa acggcacttt atccaagaca cctgcctcta     4140

tgagtgttcc ccgaacttgg gaccctggat ccagcaggtg gaccagagct ggcgcaaaga     4200

gcggatcctt gatgttcccc tgtgcaaaga ggactgtcag cagtggtggg aggactgcca     4260

gagctctttt acctgcaaga gcaattggca caagggatgg aactggtcct cggggcataa     4320

cgagtgtcct gtgggagcct cctgccatcc cttcaccttc tacttcccca catctgctgc     4380

tctgtgtgag gaaatctgga gtcactccta caagctcagc aactacagtc gagggagcgg     4440

ccgctgcatt cagatgtggt tcgacccagc ccagggcaac cccaacgagg aagtggcgag     4500

gttctatgcc gaggccatga gtggagctgg gtttcatggg acctggccac tcttgtgcag     4560

cctgtcctta gtgctgctct gggtgatcag ctgaaaacta cgggctgcag gaattccgcc     4620

cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct     4680

atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc     4740

ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc     4800

tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg     4860

tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa     4920

agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt     4980

ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg     5040

atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta     5100

catgtgttta gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt     5160

cctttgaaaa acacgatgat aataccatgg tgagcaaggg cgaggagctg ttcaccgggg     5220

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     5280

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     5340

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     5400

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     5460

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     5520

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     5580

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     5640

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     5700

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     5760

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     5820

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     5880

tcggcatgga cgagctgtac aagtccggac tcagatctcg actagctagt agctagctag     5940

ctagtcgagc tcaagcttcg aattcgatat caagcttatc gcgataccgt cgacctcgag     6000

ggaattccga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     6060

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     6120

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     6180

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     6240

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     6300

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     6360

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc     6420

catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     6480

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     6540

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     6600

atcgggaatt cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt     6660

agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa     6720

gatgggatca attcaccatg ggaataactt cgtatagcat acattatacg aagttatgct     6780

gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg     6840

ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt     6900

gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt     6960

gtggaaaatc tctagcagca tctagaatta attccgtgta ttctatagtg tcacctaaat     7020

cgtatgtgta tgatacataa ggttatgtat taattgtagc cgcgttctaa cgacaatatg     7080

tacaagccta attgtgtagc atctggctta ctgaagcaga ccctatcatc tctctcgtaa     7140

actgccgtca gagtcggttt ggttggacga accttctgag tttctggtaa cgccgtcccg     7200

cacccggaaa tggtcagcga accaatcagc agggtcatcg ctagccagat cctctacgcc     7260

ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc     7320

gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc     7380

gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc cttgcatgca     7440

ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg cttcctaatg     7500

caggagtcgc ataagggaga gcgtcgaatg gtgcactctc agtacaatct gctctgatgc     7560

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     7620

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     7680

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt     7740

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     7800

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     7860

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     7920

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     7980

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     8040

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     8100

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     8160

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     8220

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     8280

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     8340

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     8400

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     8460

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     8520

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     8580

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     8640

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     8700

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     8760

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     8820

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     8880

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     8940

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     9000

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     9060

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     9120

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     9180

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     9240

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     9300

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     9360

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     9420

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     9480

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     9540

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     9600

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     9660

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     9720

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct gtggaatgtg     9780

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     9840

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     9900

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     9960

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt    10020

atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc    10080

ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt gcgagatatg    10140

tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag acgcggactc    10200

atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac ctattttccc    10260

ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga gcgaaaaata    10320

catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc gactgatgcc    10380

ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc gggtgcgtta    10440

ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag ctacgatcac    10500

gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga aggcttcatc    10560

gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga aatgtatcca    10620

aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt tgatgactat    10680

gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg cgtcgtattc    10740

gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg cgttgttctt    10800

tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg catccatgac    10860

acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg aaacctcgac    10920

gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc ttgatggtaa    10980

aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc gcggcattga    11040

cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg aacgtaccga    11100

cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt atgagtgggc    11160

cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac aaactaccta    11220

cagagattta aagctctaag gtaaatataa aatttttaag tgtataatgt gttaaactac    11280

tgattctaat tgtttgtgta ttttagattc caacctatgg aactgatgaa tgggagcagt    11340

ggtggaatgc ctttaatgag gaaaacctgt tttgctcaga agaaatgcca tctagtgatg    11400

atgaggctac tgctgactct caacattcta ctcctccaaa aaagaagaga aaggtagaag    11460

accccaagga ctttccttca gaattgctaa gttttttgag tcatgctgtg tttagtaata    11520

gaactcttgc ttgctttgct atttacacca caaaggaaaa agctgcactg ctatacaaga    11580

aaattatgga aaaatattct gtaaccttta taagtaggca taacagttat aatcataaca    11640

tactgttttt tcttactcca cacaggcata gagtgtctgc tattaataac tatgctcaaa    11700

aattgtgtac ctttagcttt ttaatttgta aaggggttaa taaggaatat ttgatgtata    11760

gtgccttgac tagagatcat aatcagccat accacatttg tagaggtttt acttgcttta    11820

aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt    11880

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca    11940

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    12000

tatcatgtct ggatcaactg gataactcaa gctaaccaaa atcatcccaa acttcccacc    12060

ccatacccta ttaccactgc caattaccta gtggtttcat ttactctaaa cctgtgattc    12120

ctctgaatta ttttcatttt aaagaaattg tatttgttaa atatgtacta caaacttagt    12180

ag                                                                   12182


<210>  9
<211>  10447
<212>  DNA
<213>  artificial

<220>
<223>  pHR EcorI hAnti cd19 1D3 myc hinge cd28 cd3zeta

<400>  9
cgataccgtc gaccaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac       60

tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc      120

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      180

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      240

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagcatct      300

agaattaatt ccgtgtattc tatagtgtca cctaaatcgt atgtgtatga tacataaggt      360

tatgtattaa ttgtagccgc gttctaacga caatatgtac aagcctaatt gtgtagcatc      420

tggcttactg aagcagaccc tatcatctct ctcgtaaact gccgtcagag tcggtttggt      480

tggacgaacc ttctgagttt ctggtaacgc cgtcccgcac ccggaaatgg tcagcgaacc      540

aatcagcagg gtcatcgcta gccagatcct ctacgccgga cgcatcgtgg ccggcatcac      600

cggcgccaca ggtgcggttg ctggcgccta tatcgccgac atcaccgatg gggaagatcg      660

ggctcgccac ttcgggctca tgagcgcttg tttcggcgtg ggtatggtgg caggccccgt      720

ggccggggga ctgttgggcg ccatctcctt gcatgcacca ttccttgcgg cggcggtgct      780

caacggcctc aacctactac tgggctgctt cctaatgcag gagtcgcata agggagagcg      840

tcgaatggtg cactctcagt acaatctagc tctgatgccg catagttaag ccagccccga      900

cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac      960

agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg     1020

aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata     1080

ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt     1140

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     1200

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     1260

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     1320

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     1380

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     1440

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     1500

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     1560

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     1620

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     1680

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     1740

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     1800

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     1860

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     1920

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     1980

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     2040

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     2100

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     2160

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     2220

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     2280

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     2340

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     2400

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     2460

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     2520

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     2580

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     2640

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     2700

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     2760

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     2820

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     2880

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     2940

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     3000

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc     3060

gcgcgttggc cgattcatta atgcagctgt ggaatgtgtg tcagttaggg tgtggaaagt     3120

ccccaggctc cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     3180

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     3240

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     3300

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     3360

cctcggcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     3420

gcaaaaagct tggacacaag acaggcttgc gagatatgtt tgagaatacc actttatccc     3480

gcgtcaggga gaggcagtgc gtaaaaagac gcggactcat gtgaaatact ggtttttagt     3540

gcgccagatc tctataatct cgcgcaacct attttcccct cgaacacttt ttaagccgta     3600

gataaacagg ctgggacact tcacatgagc gaaaaataca tcgtcacctg ggacatgttg     3660

cagatccatg cacgtaaact cgcaagccga ctgatgcctt ctgaacaatg gaaaggcatt     3720

attgccgtaa gccgtggcgg tctgtaccgg gtgcgttact ggcgcgtgaa ctgggtattc     3780

gtcatgtcga taccgtttgt atttccagct acgatcacga caaccagcgc gagcttaaag     3840

tgctgaaacg cgcagaaggc gatggcgaag gcttcatcgt tattgatgac ctggtggata     3900

ccggtggtac tgcggttgcg attcgtgaaa tgtatccaaa agcgcacttt gtcaccatct     3960

tcgcaaaacc ggctggtcgt ccgctggttg atgactatgt tgttgatatc ccgcaagata     4020

cctggattga acagccgtgg gatatgggcg tcgtattcgt cccgccaatc tccggtcgct     4080

aatcttttca acgcctggca ctgccgggcg ttgttctttt taacttcagg cgggttacaa     4140

tagtttccag taagtattct ggaggctgca tccatgacac aggcaaacct gagcgaaacc     4200

ctgttcaaac cccgctttaa acatcctgaa acctcgacgc tagtccgccg ctttaatcac     4260

ggcgcacaac cgcctgtgca gtcggccctt gatggtaaaa ccatccctca ctggtatcgc     4320

atgattaacc gtctgatgtg gatctggcgc ggcattgacc cacgcgaaat cctcgacgtc     4380

caggcacgta ttgtgatgag cgatgccgaa cgtaccgacg atgatttata cgatacggtg     4440

attggctacc gtggcggcaa ctggatttat gagtgggccc cggatctttg tgaaggaacc     4500

ttacttctgt ggtgtgacat aattggacaa actacctaca gagatttaaa gctctaaggt     4560

aaatataaaa tttttaagtg tataatgtgt taaactactg attctaattg tttgtgtatt     4620

ttagattcca acctatggaa ctgatgaatg ggagcagtgg tggaatgcct ttaatgagga     4680

aaacctgttt tgctcagaag aaatgccatc tagtgatgat gaggctactg ctgactctca     4740

acattctact cctccaaaaa agaagagaaa ggtagaagac cccaaggact ttccttcaga     4800

attgctaagt tttttgagtc atgctgtgtt tagtaataga actcttgctt gctttgctat     4860

ttacaccaca aaggaaaaag ctgcactgct atacaagaaa attatggaaa aatattctgt     4920

aacctttata agtaggcata acagttataa tcataacata ctgttttttc ttactccaca     4980

caggcataga gtgtctgcta ttaataacta tgctcaaaaa ttgtgtacct ttagcttttt     5040

aatttgtaaa ggggttaata aggaatattt gatgtatagt gccttgacta gagatcataa     5100

tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc     5160

tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata     5220

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     5280

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atcaactgga     5340

taactcaagc taaccaaaat catcccaaac ttcccacccc ataccctatt accactgcca     5400

attacctagt ggtttcattt actctaaacc tgtgattcct ctgaattatt ttcattttaa     5460

agaaattgta tttgttaaat atgtactaca aacttagtag ttggaagggc taattcactc     5520

ccaaagaaga caagatatcc ttgatctgtg gatctaccac acacaaggct acttccctga     5580

ttagcagaac tacacaccag ggccaggggt cagatatcca ctgacctttg gatggtgcta     5640

caagctagta ccagttgagc cagataaggt agaagaggcc aataaaggag agaacaccag     5700

cttgttacac cctgtgagcc tgcatgggat ggatgacccg gagagagaag tgttagagtg     5760

gaggtttgac agccgcctag catttcatca cgtggcccga gagctgcatc cggagtactt     5820

caagaactgc tgatatcgag cttgctacaa gggactttcc gctggggact ttccagggag     5880

gcgtggcctg ggcgggactg gggagtggcg agccctcaga tcctgcatat aagcagctgc     5940

tttttgcctg tactgggtct ctctggttag accagatctg agcctgggag ctctctggct     6000

aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt     6060

gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt     6120

ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa gcgaaaggga aaccagagga     6180

gctctctcga cgcaggactc ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg     6240

actggtgagt acgccaaaaa ttttgactag cggaggctag aaggagagag atgggtgcga     6300

gagcgtcagt attaagcggg ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc     6360

agggggaaag aaaaaatata aattaaaaca tatagtatgg gcaagcaggg agctagaacg     6420

attcgcagtt aatcctggcc tgttagaaac atcagaaggc tgtagacaaa tactgggaca     6480

gctacaacca tcccttcaga caggatcaga agaacttaga tcattatata atacagtagc     6540

aaccctctat tgtgtgcatc aaaggataga gataaaagac accaaggaag ctttagacaa     6600

gatagaggaa gagcaaaaca aaagtaagac caccgcacag caagcggccg gtgatcttca     6660

gacctggacg atatatatga gggacaattg gagaagtgaa ttatataaat ataaagtagt     6720

aaaaattgaa ccattaggag tagcacccac caaggcaaag agaagagtgg tgcagagaga     6780

aaaaagagca gtgggaatag gagctttgtt ccttgggttc ttgggagcag caggaagcac     6840

tatgggcgca gcgtcaatga cgctgacggt acaggccaga caattattgt ctggtatagt     6900

gcagcagcag aacaatttgc tgagggctat tgaggcgcaa cagcatctgt tgcaactcac     6960

agtctggggc atcaagcagc tccaggcaag aatcctggct gtggaaagat acctaaagga     7020

tcaacagctc ctggggattt ggggttgctc tggaaaactc atttgcacca ctgctgtgcc     7080

ttggaatgct agttggagta ataaatctct ggaacagatt tggaatcaca cgacctggat     7140

ggagtgggac agagaaatta acaattacac aagcttaata cactccttaa ttgaagaatc     7200

gcaaaaccag caagaaaaga atgaacaaga attattggaa ttagataaat gggcaagttt     7260

gtggaattgg tttaacataa caaattggct gtggtatata aaattattca taatgatagt     7320

aggaggcttg gtaggtttaa gaatagtttt tgctgtactt tctatagtga atagagttag     7380

gcagggatat tcaccattat cgtttcagac ccacctccca accccgaggg gacccgacag     7440

gcccgaagga atagaagaag aaggtggaga gagagacaga gacagatcca ttcgattagt     7500

gaacggatct cgacggtcgc caaatggcag tattcatcca caattttaaa agaaaagggg     7560

ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa     7620

ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca     7680

gcagagatcc agtttggatc gataagcttg atatcgaatt gggtagggga ggcgcttttc     7740

ccaaggcagt ctggagcatg cgctttagca gccccgctgg gcacttggcg ctacacaagt     7800

ggcctctggc ctcgcacaca ttccacatcc accggtaggc gccaaccggc tccgttcttt     7860

ggtggcccct tcgcgccacc ttctactcct cccctagtca ggaagttccc ccccgccccg     7920

cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac gtctcactag tctcgtgcag     7980

atggacagca ccgctgagca atggaagcgg gtaggccttt ggggcagcgg ccaatagcag     8040

ctttgctcct tcgctttctg ggctcagagg ctgggaaggg gtgggtccgg gggcgggctc     8100

aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct ccggaggccc ggcattctgc     8160

acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt cctcatctcc gggcctttcg     8220

atggctcttc cagtgactgc tcttctcctc ccgcttgcgc tgctgttgca tgcggctcgg     8280

ccggagcaaa agctgatttc agaagaggac ttggatatcc agatgacaca gaccacttca     8340

tctctttctg ctagcctggg ggatcgggtc acaataagct gtcgcgcatc ccaagacata     8400

agcaaatatc tgaattggta tcaacagaaa cccgatggaa ctgtgaaact tctcatctac     8460

catacgagca gactgcattc tggggttcct agccgctttt cagggtctgg atctggaacg     8520

gactattcac ttaccatatc taatttggaa caagaagaca tcgcgaccta tttctgtcag     8580

caaggcaata cgctccctta tacttttgga gggggaacga agttggagat cacaggtgga     8640

ggcggcagtg gcgggggagg atctggtgga ggtggttctg aggtcaagct gcaggagagt     8700

ggtcccgggc tggtagcccc gagccagagt ctgtctgtta cttgcactgt gtcaggcgtg     8760

agtctcccag actatggtgt atcatggatt cgacagccgc cccggaaagg acttgagtgg     8820

ctcggagtga tctggggatc cgaaacgacg tactacaata gcgcgctcaa aagccggctg     8880

accatcatta aggataactc taaaagccag gtgttcttga aaatgaattc cttgcagaca     8940

gatgatacgg cgatctatta ctgtgccaag cactactact atggaggcag ctatgccatg     9000

gattattggg gtcaaggcac ttctgtgaca gtgagcagtg ccgcagctat tgaagtgatg     9060

tacccgcctc cgtatcttga taatgagaaa tctaacggaa ccataataca cgtgaaaggc     9120

aaacatttgt gtccgtctcc tctgttcccc gggcctagta aaccgttttg ggtactggtg     9180

gtggtaggcg gagtacttgc atgttactca ctcctcgtta ccgtcgcatt cattatcttc     9240

tgggtacgga gcaagagatc tcggctgctt catagcgatt atatgaatat gacacccaga     9300

cgcccaggtc ctactaggaa acattaccag ccgtatgcgc cgccgaggga cttcgccgca     9360

tacagatctc gcgtgaagtt ctcaagatct gccgatgcac cggcttatca gcagggacaa     9420

aaccaactgt ataatgagct gaacctgggg cggagggagg agtatgatgt cctggacaag     9480

cgaagagggc gagaccccga aatgggaggc aagcctcaac ggcggaagaa cccacaagag     9540

ggcctgtata acgagcttca aaaggacaaa atggcggaag cgtatagcga gatcggaatg     9600

aagggcgaac gaaggagagg gaaaggtcac gatgggctct accaggggct cagcacggca     9660

acaaaagaca catatgacgc attgcatatg caggcgctgc caccgagatg actcacgcgt     9720

caagtggagc aaggcaggtg gacagtggat ccttgacttg cggccgcaac tcccacctgc     9780

aacatgcgtg actgactgag gccgcgactc tagagtcgac ctgcaggcat gcaagcttga     9840

tatcaagctt atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     9900

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     9960

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc    10020

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc    10080

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt    10140

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg    10200

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc    10260

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta    10320

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg    10380

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc    10440

cccgcat                                                              10447


<210>  10
<211>  12536
<212>  DNA
<213>  artificial

<220>
<223>  pWPI pmei mAnti cd19 1D3 myc hinge cd28 cd3zeta

<400>  10
ttggaagggc taattcactc ccaaagaaga caagatatcc ttgatctgtg gatctaccac       60

acacaaggct acttccctga ttagcagaac tacacaccag ggccaggggt cagatatcca      120

ctgacctttg gatggtgcta caagctagta ccagttgagc cagataaggt agaagaggcc      180

aataaaggag agaacaccag cttgttacac cctgtgagcc tgcatgggat ggatgacccg      240

gagagagaag tgttagagtg gaggtttgac agccgcctag catttcatca cgtggcccga      300

gagctgcatc cggagtactt caagaactgc tgatatcgag cttgctacaa gggactttcc      360

gctggggact ttccagggag gcgtggcctg ggcgggactg gggagtggcg agccctcaga      420

tcctgcatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      480

agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc      540

ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct      600

cagacccttt tagtcagtgt ggaaaatctc tagcagtggc gcccgaacag ggacttgaaa      660

gcgaaaggga aaccagagga gctctctcga cgcaggactc ggcttgctga agcgcgcacg      720

gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag cggaggctag      780

aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgcgatgg      840

gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca tatagtatgg      900

gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac atcagaaggc      960

tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga agaacttaga     1020

tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga gataaaagac     1080

accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac caccgcacag     1140

caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt ggagaagtga     1200

attatataaa tataaagtag taaaaattga accattagga gtagcaccca ccaaggcaaa     1260

gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt tccttgggtt     1320

cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg tacaggccag     1380

acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta ttgaggcgca     1440

acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa gaatcctggc     1500

tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct ctggaaaact     1560

catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc tggaacagat     1620

ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca caagcttaat     1680

acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag aattattgga     1740

attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc tgtggtatat     1800

aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt ttgctgtact     1860

ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga cccacctccc     1920

aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag agagagacag     1980

agacagatcc attcgattag tgaacggatc tcgacggtat cgatgtcgac gataagcttt     2040

gcaaagatgg ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt     2100

cttgaaagga gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     2160

agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg     2220

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     2280

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     2340

cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg     2400

cccttgcgtg ccttgaatta cttccactgg ctgcagtacg tgattcttga tcccgagctt     2460

cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc ttcgcctcgt     2520

gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg gtggcacctt     2580

cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg atgacctgct     2640

gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct gcacactggt     2700

atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg cacatgttcg     2760

gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc tcaagctggc     2820

cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg ggcggcaagg     2880

ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg ccctgctgca     2940

gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc acccacacaa     3000

aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga gtaccgggcg     3060

ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt aggttggggg     3120

gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga agttaggcca     3180

gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg atcttggttc     3240

attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt gtcgtgagga     3300

atttcgacat ttaaatttaa ttaatctcga cggtatcggt taacttttaa aagaaaaggg     3360

gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac agacatacaa     3420

actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatca cgagactagc     3480

ctcgaggttt atgggggttc ccacccagct gttggggttg ctgctcctct ggatcactga     3540

tgccatctgc gaacagaagc tcatttctga agaagatctg gacatacaga tgacccagag     3600

tcctgccagc ttgtccacat ccctcggaga gaccgtgaca attcaatgcc aggcctctga     3660

ggacatatat tctggattgg cttggtacca gcaaaagcca ggtaaaagtc ctcagttgtt     3720

gatatacggc gcttctgatt tgcaagacgg ggtgccctca cgatttagcg ggtctggaag     3780

tggcactcag tacagtctga agattacttc aatgcaaaca gaagacgagg gtgtgtattt     3840

ttgccaacag gggctgacct acccaaggac attcgggggc ggtacaaagc ttgaacttaa     3900

gggcggcggt gggtctggag gtggtggatc tggcggaggg ggaagtgagg tacagctgca     3960

acagtccggc gccgaactcg ttcgccctgg aacctcagtc aaattgtcat gcaaggtgag     4020

tggcgacaca ataacctttt actatatgca cttcgttaaa cagaggccag gtcaaggtct     4080

ggaatggata ggcagaattg atccagaaga tgagtccacc aaatactcag aaaagttcaa     4140

aaacaaagcc actcttactg ccgacacctc aagcaacaca gcatatctta agctcagttc     4200

acttaccagc gaagacaccg ccacctattt ttgtatttat ggtggctatt actttgacta     4260

ctgggggcaa ggtgttatgg taacagtttc ttccattgaa ttcatgtatc caccccccta     4320

tttggataat gaacgatcta atgggactat aatacatatc aaggaaaagc atctgtgtca     4380

tacccaaagt tcccctaagc ttttctgggc cctcgtcgtt gtggcaggag tgcttttttg     4440

ctatggattg ttggttactg tggctctctg cgtcatttgg acaaatagta ggaggaatcg     4500

ggggggacaa tctgattaca tgaacatgac accacggagg ccaggcctta ccagaaagcc     4560

ctaccaacct tatgcaccag cacgagactt cgccgcatac aggccaaggg ctaagttttc     4620

ccgcagcgcc gaaaccgcag ccaacctcca agatcctaat cagctctata acgaattgaa     4680

tcttggccgc agagaggagt acgacgtact tgagaaaaag agagctaggg accctgaaat     4740

gggtgggaag caacagcgaa gaaggaaccc acaggaaggg gtgtataatg cccttcaaaa     4800

ggataaaatg gcagaggcat acagtgaaat cggaaccaag ggggagagac gcagagggaa     4860

aggccatgac ggcctttatc agggtttgtc aactgctact aaagacactt atgatgcctt     4920

gcatatgcaa actctcgcac ccagatgaaa actacgggct gcaggaattc cgcccccccc     4980

cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt     5040

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct     5100

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga     5160

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga     5220

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac     5280

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag     5340

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc     5400

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg     5460

tttagtcgag gttaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg     5520

aaaaacacga tgataatacc atggtgagca agggcgagga gctgttcacc ggggtggtgc     5580

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     5640

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     5700

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     5760

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     5820

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     5880

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     5940

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     6000

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     6060

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     6120

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     6180

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     6240

tggacgagct gtacaagtcc ggactcagat ctcgactagc tagtagctag ctagctagtc     6300

gagctcaagc ttcgaattcg atatcaagct tatcgcgata ccgtcgacct cgagggaatt     6360

ccgataatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg     6420

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt     6480

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg     6540

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc     6600

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc     6660

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     6720

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc tttccatggc     6780

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg     6840

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc     6900

gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcatcggg     6960

aattcgagct cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac     7020

tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatggg     7080

atcaattcac catgggaata acttcgtata gcatacatta tacgaagtta tgctgctttt     7140

tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact     7200

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc     7260

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa     7320

aatctctagc agcatctaga attaattccg tgtattctat agtgtcacct aaatcgtatg     7380

tgtatgatac ataaggttat gtattaattg tagccgcgtt ctaacgacaa tatgtacaag     7440

cctaattgtg tagcatctgg cttactgaag cagaccctat catctctctc gtaaactgcc     7500

gtcagagtcg gtttggttgg acgaaccttc tgagtttctg gtaacgccgt cccgcacccg     7560

gaaatggtca gcgaaccaat cagcagggtc atcgctagcc agatcctcta cgccggacgc     7620

atcgtggccg gcatcaccgg cgccacaggt gcggttgctg gcgcctatat cgccgacatc     7680

accgatgggg aagatcgggc tcgccacttc gggctcatga gcgcttgttt cggcgtgggt     7740

atggtggcag gccccgtggc cgggggactg ttgggcgcca tctccttgca tgcaccattc     7800

cttgcggcgg cggtgctcaa cggcctcaac ctactactgg gctgcttcct aatgcaggag     7860

tcgcataagg gagagcgtcg aatggtgcac tctcagtaca atctgctctg atgccgcata     7920

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     7980

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     8040

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     8100

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     8160

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     8220

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     8280

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     8340

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     8400

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     8460

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     8520

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     8580

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     8640

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     8700

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     8760

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     8820

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     8880

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     8940

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     9000

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     9060

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     9120

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     9180

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     9240

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     9300

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     9360

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     9420

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     9480

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     9540

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     9600

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     9660

caccgaactg agatacctac agcgtgagca ttgagaaagc gccacgcttc ccgaagggag     9720

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     9780

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     9840

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     9900

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt     9960

atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg    10020

cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg    10080

caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctgtggaa tgtgtgtcag    10140

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc    10200

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa    10260

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc    10320

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat    10380

gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt    10440

ggaggcctag gcttttgcaa aaagcttgga cacaagacag gcttgcgaga tatgtttgag    10500

aataccactt tatcccgcgt cagggagagg cagtgcgtaa aaagacgcgg actcatgtga    10560

aatactggtt tttagtgcgc cagatctcta taatctcgcg caacctattt tcccctcgaa    10620

cactttttaa gccgtagata aacaggctgg gacacttcac atgagcgaaa aatacatcgt    10680

cacctgggac atgttgcaga tccatgcacg taaactcgca agccgactga tgccttctga    10740

acaatggaaa ggcattattg ccgtaagccg tggcggtctg taccgggtgc gttactggcg    10800

cgtgaactgg gtattcgtca tgtcgatacc gtttgtattt ccagctacga tcacgacaac    10860

cagcgcgagc ttaaagtgct gaaacgcgca gaaggcgatg gcgaaggctt catcgttatt    10920

gatgacctgg tggataccgg tggtactgcg gttgcgattc gtgaaatgta tccaaaagcg    10980

cactttgtca ccatcttcgc aaaaccggct ggtcgtccgc tggttgatga ctatgttgtt    11040

gatatcccgc aagatacctg gattgaacag ccgtgggata tgggcgtcgt attcgtcccg    11100

ccaatctccg gtcgctaatc ttttcaacgc ctggcactgc cgggcgttgt tctttttaac    11160

ttcaggcggg ttacaatagt ttccagtaag tattctggag gctgcatcca tgacacaggc    11220

aaacctgagc gaaaccctgt tcaaaccccg ctttaaacat cctgaaacct cgacgctagt    11280

ccgccgcttt aatcacggcg cacaaccgcc tgtgcagtcg gcccttgatg gtaaaaccat    11340

ccctcactgg tatcgcatga ttaaccgtct gatgtggatc tggcgcggca ttgacccacg    11400

cgaaatcctc gacgtccagg cacgtattgt gatgagcgat gccgaacgta ccgacgatga    11460

tttatacgat acggtgattg gctaccgtgg cggcaactgg atttatgagt gggccccgga    11520

tctttgtgaa ggaaccttac ttctgtggtg tgacataatt ggacaaacta cctacagaga    11580

tttaaagctc taaggtaaat ataaaatttt taagtgtata atgtgttaaa ctactgattc    11640

taattgtttg tgtattttag attccaacct atggaactga tgaatgggag cagtggtgga    11700

atgcctttaa tgaggaaaac ctgttttgct cagaagaaat gccatctagt gatgatgagg    11760

ctactgctga ctctcaacat tctactcctc caaaaaagaa gagaaaggta gaagacccca    11820

aggactttcc ttcagaattg ctaagttttt tgagtcatgc tgtgtttagt aatagaactc    11880

ttgcttgctt tgctatttac accacaaagg aaaaagctgc actgctatac aagaaaatta    11940

tggaaaaata ttctgtaacc tttataagta ggcataacag ttataatcat aacatactgt    12000

tttttcttac tccacacagg catagagtgt ctgctattaa taactatgct caaaaattgt    12060

gtacctttag ctttttaatt tgtaaagggg ttaataagga atatttgatg tatagtgcct    12120

tgactagaga tcataatcag ccataccaca tttgtagagg ttttacttgc tttaaaaaac    12180

ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt tgttaacttg    12240

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa    12300

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat    12360

gtctggatca actggataac tcaagctaac caaaatcatc ccaaacttcc caccccatac    12420

cctattacca ctgccaatta cctagtggtt tcatttactc taaacctgtg attcctctga    12480

attattttca ttttaaagaa attgtatttg ttaaatatgt actacaaact tagtag        12536


<210>  11
<211>  365
<212>  PRT
<213>  artificial

<220>
<223>  FKBP-1SG-FR with GPI anchor amino acid sequence

<400>  11

Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val Ala Val Val Gly 
1               5                   10                  15      


Glu Ala Gln Thr Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser 
        115                 120                 125             


Gly Gly Gly Ser Arg Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val 
    130                 135                 140                 


Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly Pro Glu Asp Lys 
145                 150                 155                 160 


Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr 
                165                 170                 175     


Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe 
            180                 185                 190         


Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys Lys Arg His Phe 
        195                 200                 205             


Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp 
    210                 215                 220                 


Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val 
225                 230                 235                 240 


Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr 
                245                 250                 255     


Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp Asn Trp Thr Ser 
            260                 265                 270         


Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln Pro Phe His Phe 
        275                 280                 285             


Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile Trp Thr His Ser 
    290                 295                 300                 


Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met 
305                 310                 315                 320 


Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe 
                325                 330                 335     


Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe 
            340                 345                 350         


Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser 
        355                 360                 365 


<210>  12
<211>  375
<212>  PRT
<213>  artificial

<220>
<223>  FKBP-3SG-FR with GPI anchor amino acid sequence:

<400>  12

Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val Ala Val Val Gly 
1               5                   10                  15      


Glu Ala Gln Thr Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
            20                  25                  30          


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
        35                  40                  45              


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
    50                  55                  60                  


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
65                  70                  75                  80  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
                85                  90                  95      


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
            100                 105                 110         


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ile 
    130                 135                 140                 


Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His 
145                 150                 155                 160 


His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys Arg 
                165                 170                 175     


Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala 
            180                 185                 190         


His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly 
        195                 200                 205             


Glu Met Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys Leu 
    210                 215                 220                 


Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln 
225                 230                 235                 240 


Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu Asp 
                245                 250                 255     


Cys Glu Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser 
            260                 265                 270         


Asn Trp His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala 
        275                 280                 285             


Val Gly Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro Thr 
    290                 295                 300                 


Val Leu Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn Tyr 
305                 310                 315                 320 


Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala Gln 
                325                 330                 335     


Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala Ala Ala Met Ser 
            340                 345                 350         


Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu 
        355                 360                 365             


Met Leu Leu Trp Leu Leu Ser 
    370                 375 


<210>  13
<211>  513
<212>  PRT
<213>  artificial

<220>
<223>  4M5.3-FR with GPI anchor amino acid sequence

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala 
    130                 135                 140                 


Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val 
145                 150                 155                 160 


Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met 
                165                 170                 175     


Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met 
            180                 185                 190         


Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln 
        195                 200                 205             


Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val 
            260                 265                 270         


Thr Val Ser Ser Gly Gly Gly Ser Arg Ile Ala Trp Ala Arg Thr Glu 
        275                 280                 285             


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
    290                 295                 300                 


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
305                 310                 315                 320 


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
                325                 330                 335     


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
            340                 345                 350         


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
        355                 360                 365             


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
    370                 375                 380                 


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
385                 390                 395                 400 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
                405                 410                 415     


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
            420                 425                 430         


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
        435                 440                 445             


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
    450                 455                 460                 


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
465                 470                 475                 480 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
                485                 490                 495     


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
            500                 505                 510         


Ser 
    


<210>  14
<211>  895
<212>  PRT
<213>  artificial

<220>
<223>  FMC63-T2A-FKBP3SGFR

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
        275                 280                 285             


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
    290                 295                 300                 


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
                485                 490                 495     


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu 
        515                 520                 525             


Leu Val Trp Val Ala Val Val Gly Glu Ala Gln Thr Gly Val Gln Val 
    530                 535                 540                 


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
545                 550                 555                 560 


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
                565                 570                 575     


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
            580                 585                 590         


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
        595                 600                 605             


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
    610                 615                 620                 


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
625                 630                 635                 640 


Val Glu Leu Leu Lys Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Arg Ile Ala Trp Ala Arg Thr Glu Leu Leu 
            660                 665                 670         


Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly Pro Glu 
        675                 680                 685             


Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys 
    690                 695                 700                 


Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr Leu Tyr 
705                 710                 715                 720 


Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys Lys Arg 
                725                 730                 735     


His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly 
            740                 745                 750         


Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu 
        755                 760                 765             


Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu Asp Cys 
    770                 775                 780                 


Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp Asn Trp 
785                 790                 795                 800 


Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln Pro Phe 
                805                 810                 815     


His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile Trp Thr 
            820                 825                 830         


His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile 
        835                 840                 845             


Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu Val Ala 
    850                 855                 860                 


Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala Ala Trp 
865                 870                 875                 880 


Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser 
                885                 890                 895 


<210>  15
<211>  1029
<212>  PRT
<213>  artificial

<220>
<223>  FMC63-T2A-4M5.3SGFR

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn 
        275                 280                 285             


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
    290                 295                 300                 


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
                485                 490                 495     


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr 
    530                 535                 540                 


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
545                 550                 555                 560 


Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg 
                565                 570                 575     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys 
            580                 585                 590         


Val Ser Asn Arg Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        595                 600                 605             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp 
    610                 615                 620                 


Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe 
625                 630                 635                 640 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Ser Ala Asp Asp Ala Lys 
                645                 650                 655     


Lys Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys 
            660                 665                 670         


Asp Gly Gly Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro 
        675                 680                 685             


Gly Gly Ala Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly 
    690                 695                 700                 


His Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu 
705                 710                 715                 720 


Trp Val Ala Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr 
                725                 730                 735     


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
            740                 745                 750         


Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly 
        755                 760                 765             


Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln 
    770                 775                 780                 


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Ser Arg Ile Ala Trp 
785                 790                 795                 800 


Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys 
                805                 810                 815     


Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp 
            820                 825                 830         


Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys 
        835                 840                 845             


Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met 
    850                 855                 860                 


Ala Pro Ala Cys Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu 
865                 870                 875                 880 


Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp 
                885                 890                 895     


Arg Lys Glu Arg Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu 
            900                 905                 910         


Gln Trp Trp Glu Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp 
        915                 920                 925             


His Lys Gly Trp Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly 
    930                 935                 940                 


Ala Ala Cys Gln Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu 
945                 950                 955                 960 


Cys Asn Glu Ile Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg 
                965                 970                 975     


Gly Ser Gly Arg Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn 
            980                 985                 990         


Pro Asn Glu Glu Val Ala Arg Phe  Tyr Ala Ala Ala Met  Ser Gly Ala 
        995                 1000                 1005             


Gly Pro  Trp Ala Ala Trp Pro  Phe Leu Leu Ser Leu  Ala Leu Met 
    1010                 1015                 1020             


Leu Leu  Trp Leu Leu Ser 
    1025                 


<210>  16
<211>  255
<212>  PRT
<213>  artificial

<220>
<223>  FRb with signal peptide

<400>  16

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  17
<211>  335
<212>  PRT
<213>  artificial

<220>
<223>  uPAR with signal peptide

<400>  17

Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys 
1               5                   10                  15      


Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly 
            20                  25                  30          


Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr 
        35                  40                  45              


Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu 
    50                  55                  60                  


Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg 
65                  70                  75                  80  


Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp 
                85                  90                  95      


Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser 
            100                 105                 110         


Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu 
        115                 120                 125             


Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys 
    130                 135                 140                 


Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro 
145                 150                 155                 160 


Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro 
                165                 170                 175     


Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys 
            180                 185                 190         


Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn 
        195                 200                 205             


Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr 
    210                 215                 220                 


His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro 
225                 230                 235                 240 


Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln 
                245                 250                 255     


Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala 
            260                 265                 270         


His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys 
        275                 280                 285             


Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser 
    290                 295                 300                 


Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr 
305                 310                 315                 320 


Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr 
                325                 330                 335 


<210>  18
<211>  187
<212>  PRT
<213>  artificial

<220>
<223>  DHFR

<400>  18

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  19
<211>  255
<212>  PRT
<213>  artificial

<220>
<223>  scFv against FITC: 4M5.3(Kd = 200pM)

<400>  19

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
        115                 120                 125             


Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val Lys Leu Asp Glu Thr 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser Cys Val 
145                 150                 155                 160 


Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val Arg Gln 
                165                 170                 175     


Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn Lys Pro 
            180                 185                 190         


Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn 
    210                 215                 220                 


Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr 
225                 230                 235                 240 


Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 250                 255 


<210>  20
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  scFv against FITC 4D5Flu (Kd=10nM)

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
                165                 170                 175     


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
    210                 215                 220                 


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  21
<211>  244
<212>  PRT
<213>  artificial

<220>
<223>  scFv against DNP SPE7

<400>  21

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp 
145                 150                 155                 160 


Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile Gly Arg Ile Asp 
                165                 170                 175     


Pro Asn Gly Gly Gly Thr Lys Tyr Asn Glu Lys Phe Lys Ser Lys Ala 
            180                 185                 190         


Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr Met Gln Leu Ser 
        195                 200                 205             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Met Trp 
    210                 215                 220                 


Tyr Tyr Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


