                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
       Seattle Children's Research Institute
 
<120>  IN VIVO GENE THERAPY FOR IMMUNE DEFICIENCIES

<130>  F053-0059PCT/17-065-WO-PCT/SCRI.161

<150>  US 62/459,450
<151>  2017-02-15

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  1110
<212>  DNA
<213>  artificial

<220>
<223>  codon optimized human gammaC

<400>  1
atgctgaaac caagcctgcc ctttacaagc ctgctgttcc tgcagctgcc actgctgggg       60

gtcggactga atactacaat cctgacacca aacggaaatg aggacaccac agccgatttc      120

tttctgacta ccatgcccac tgacagtctg tcagtgagca ccctgccact gcccgaggtc      180

cagtgcttcg tgtttaacgt cgaatatatg aactgtacct ggaatagctc ctctgaacct      240

cagccaacaa atctgactct gcactactgg tataagaact ctgacaatga taaggtgcag      300

aaatgctcac attatctgtt cagcgaggaa atcacctccg gctgtcagct gcagaagaaa      360

gagattcacc tgtaccagac atttgtggtc cagctgcagg atccccggga acctcggaga      420

caggccactc agatgctgaa gctgcagaac ctggtcatcc catgggctcc cgagaatctg      480

accctgcata aactgtccga gtctcagctg gaactgaact ggaacaatag gttcctgaat      540

cactgcctgg agcatctggt gcagtaccgc acagactggg atcactcttg gactgaacag      600

agtgtggact atcgacataa gtttagtctg ccttcagtgg atgggcagaa aaggtacaca      660

ttcagggtcc gctctcggtt caacccactg tgcggaagcg cccagcactg gagcgagtgg      720

tcccacccca tccattgggg gtctaacacc agcaaggaga atcctttcct gtttgccctg      780

gaagctgtgg tcatttcagt gggaagcatg ggcctgatca ttagcctgct gtgcgtgtac      840

ttctggctgg agcggaccat gcctagaatc ccaacactga agaacctgga ggacctggtg      900

acagaatatc acggcaattt ttccgcttgg tctggggtca gtaaaggact ggcagagagc      960

ctgcagcccg attactccga gcggctgtgc ctggtgtccg aaattccccc taaaggcggg     1020

gcactgggag aaggccctgg ggcctccccc tgcaaccagc actcacccta ttgggcacca     1080

ccctgttaca ccctgaaacc cgaaacttaa                                      1110


<210>  2
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  2
atgttgaagc catcattacc attcacatcc ctcttattcc tgcagctgcc cctgctggga       60

gtggggctga acacgacaat tctgacgccc aatgggaatg aagacaccac agctgatttc      120

ttcctgacca ctatgcccac tgactccctc agcgtttcca ctctgcccct cccagaggtt      180

cagtgttttg tgttcaatgt cgagtacatg aattgcactt ggaacagcag ctctgagccc      240

cagcctacca acctcactct gcattattgg tacaagaact cggataatga taaagtccag      300

aagtgcagcc actatctatt ctctgaagaa atcacttctg gctgtcagtt gcaaaaaaag      360

gagatccacc tctaccaaac atttgttgtt cagctccagg acccacggga acccaggaga      420

caggccacac agatgctaaa actgcagaat ctggtgatcc cctgggctcc agagaaccta      480

acacttcaca aactgagtga atcccagcta gaactgaact ggaacaacag attcttgaac      540

cactgtttgg agcacttggt gcagtaccgg actgactggg accacagctg gactgaacaa      600

tcagtggatt atagacataa gttctccttg cctagtgtgg atgggcagaa acgctacacg      660

tttcgtgttc ggagccgctt taacccactc tgtggaagtg ctcagcattg gagtgaatgg      720

agccacccaa tccactgggg gagcaatact tcaaaagaga atcctttcct gtttgcattg      780

gaagccgtgg ttatctctgt tggctccatg ggattgatta tcagccttct ctgtgtgtat      840

ttctggctgg aacggacgat gccccgaatt cccaccctga agaacctaga ggatcttgtt      900

actgaatacc acgggaactt ttcggcctgg agtggtgtgt ctaagggact ggctgagagt      960

ctgcagccag actacagtga acgactctgc ctcgtcagtg agattccccc aaaaggaggg     1020

gcccttgggg aggggcctgg ggcctcccca tgcaaccagc atagccccta ctgggccccc     1080

ccatgttaca ccctaaagcc tgaaacctga                                      1110


<210>  3
<211>  1114
<212>  DNA
<213>  Canis lupus familiaris

<400>  3
atgttgaagc caccattgcc actcagatcc ctcttattcc tgcagctgtc tctgctgggg       60

gtggggctga actccacggt ccccatgccc aatgggaatg aagacatcac acctgatttc      120

ttcctgaccg ctacaccctc cgagaccctc agtgtttcct ccctgcccct cccagaggtc      180

cagtgttttg tgttcaatgt tgagtacatg aattgcactt ggaacagcag ctctgagccc      240

cggcccacca acctgaccct gcactactgg tataagaact ccaatgatga taaagtccag      300

gagtgtggcc actacctatt ctctagagag gtcactgctg gctgttggtt gcagaaggag      360

gagatccatc tctacgaaac atttgttgtc cagctccggg acccacggga acccaggagg      420

cagtccacac agaagctaaa actgcaaaat ctggtgatcc cctgggctcc ggagaaccta      480

acccttcaca acctgagcga atcccagcta gaactgagct ggagcaacag acacttggac      540

cactgtttgg agcatgttgt gcagtaccgg agtgactggg accgcagctg gactgaacag      600

tcagtggacc accgaaatag cttctctctg cctagcgtgg atgggcagaa gttctacacg      660

ttccgtgtcc gaagccgcta taacccactc tgtggaagcg ctcagcgttg gagtgaatgg      720

agccacccta tccactgggg gagcaatacc tccaaggaga atcctttgtt tgcatcggaa      780

gctgtgctta tcccccttgg ctccatggga ttgattatta gccttatctg tgtgtactac      840

tggctggaac ggtcgatccc ccgaattcct accctcaaga acctggagga tctggttact      900

gaatatcacg ggaatttttc ggcctggagt ggagtgtcta agggactggc ggagagtctg      960

cagccagact acagtgaatg gctctgccac gtcagtgaga ttcccccaaa aggaggggct     1020

ccaggggagg gtcctggggg ctccccctgc agccagcata gcccctactg ggctccccca     1080

tgttataccc tgaaacctga aactggagcc ctga                                 1114


<210>  4
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  5
<211>  373
<212>  PRT
<213>  Canis lupus familiaris

<400>  5

Met Leu Lys Pro Pro Leu Pro Leu Arg Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Ser Leu Leu Gly Val Gly Leu Asn Ser Thr Val Pro Met Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Ile Thr Pro Asp Phe Phe Leu Thr Ala Thr Pro Ser Glu 
        35                  40                  45              


Thr Leu Ser Val Ser Ser Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Arg Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asn Asp 
                85                  90                  95      


Asp Lys Val Gln Glu Cys Gly His Tyr Leu Phe Ser Arg Glu Val Thr 
            100                 105                 110         


Ala Gly Cys Trp Leu Gln Lys Glu Glu Ile His Leu Tyr Glu Thr Phe 
        115                 120                 125             


Val Val Gln Leu Arg Asp Pro Arg Glu Pro Arg Arg Gln Ser Thr Gln 
    130                 135                 140                 


Lys Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Asn Leu Ser Glu Ser Gln Leu Glu Leu Ser Trp Ser Asn 
                165                 170                 175     


Arg His Leu Asp His Cys Leu Glu His Val Val Gln Tyr Arg Ser Asp 
            180                 185                 190         


Trp Asp Arg Ser Trp Thr Glu Gln Ser Val Asp His Arg Asn Ser Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Phe Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Tyr Asn Pro Leu Cys Gly Ser Ala Gln Arg Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Leu 
                245                 250                 255     


Phe Ala Ser Glu Ala Val Leu Ile Pro Leu Gly Ser Met Gly Leu Ile 
            260                 265                 270         


Ile Ser Leu Ile Cys Val Tyr Tyr Trp Leu Glu Arg Ser Ile Pro Arg 
        275                 280                 285             


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
    290                 295                 300                 


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
305                 310                 315                 320 


Gln Pro Asp Tyr Ser Glu Trp Leu Cys His Val Ser Glu Ile Pro Pro 
                325                 330                 335     


Lys Gly Gly Ala Pro Gly Glu Gly Pro Gly Gly Ser Pro Cys Ser Gln 
            340                 345                 350         


His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
        355                 360                 365             


Gly Ala Leu Ile Pro 
    370             


<210>  6
<211>  3375
<212>  DNA
<213>  Homo sapiens

<400>  6
atggcacctc caagtgaaga gacgcccctg atccctcagc gttcatgcag cctcttgtcc       60

acggaggctg gtgccctgca tgtgctgctg cccgctcggg gccccgggcc cccccagcgc      120

ctatctttct cctttgggga ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc      180

agcggcatcc tgcctgtgta ccactccctc tttgctctgg ccacggagga cctgtcctgc      240

tggttccccc cgagccacat cttctccgtg gaggatgcca gcacccaagt cctgctgtac      300

aggattcgct tttacttccc caattggttt gggctggaga agtgccaccg cttcgggcta      360

cgcaaggatt tggccagtgc tatccttgac ctgccagtcc tggagcacct ctttgcccag      420

caccgcagtg acctggtgag tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt      480

gagtgtctca gcctggccgt gttggacctg gcccggatgg cgcgagagca ggcccagcgg      540

ccgggagagc tgctgaagac tgtcagctac aaggcctgcc tacccccaag cctgcgcgac      600

ctgatccagg gcctgagctt cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc      660

ctgcgccgcg tggccgcctg ccaggcagac cggcactcgc tcatggccaa gtacatcatg      720

gacctggagc ggctggatcc agccggggcc gccgagacct tccacgtggg cctccctggg      780

gcccttggtg gccacgacgg gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc      840

tggacccagg gagaacagga ggtcctccag cccttctgcg actttccaga aatcgtagac      900

attagcatca agcaggcccc gcgcgttggc ccggccggag agcaccgcct ggtcactgtt      960

accaggacag acaaccagat tttagaggcc gagttcccag ggctgcccga ggctctgtcg     1020

ttcgtggcgc tcgtggacgg ctacttccgg ctgaccacgg actcccagca cttcttctgc     1080

aaggaggtgg caccgccgag gctgctggag gaagtggccg agcagtgcca cggccccatc     1140

actctggact ttgccatcaa caagctcaag actgggggct cacgtcctgg ctcctatgtt     1200

ctccgccgca gcccccagga ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc     1260

cttggtcctg attataaggg ctgcctcatc cggcgcagcc ccacaggaac cttccttctg     1320

gttggcctca gccgacccca cagcagtctt cgagagctcc tggcaacctg ctgggatggg     1380

gggctgcacg tagatggggt ggcagtgacc ctcacttcct gctgtatccc cagacccaaa     1440

gaaaagtcca acctgatcgt ggtccagaga ggtcacagcc cacccacatc atccttggtt     1500

cagccccaat cccaatacca gctgagtcag atgacatttc acaagatccc tgctgacagc     1560

ctggagtggc atgagaacct gggccatggg tccttcacca agatttaccg gggctgtcgc     1620

catgaggtgg tggatgggga ggcccgaaag acagaggtgc tgctgaaggt catggatgcc     1680

aagcacaaga actgcatgga gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg     1740

taccggcatc tcgtgctgct ccacggcgtg tgcatggctg gagacagcac catggtgcag     1800

gaatttgtac acctgggggc catagacatg tatctgcgaa aacgtggcca cctggtgcca     1860

gccagctgga agctgcaggt ggtcaaacag ctggcctacg ccctcaacta tctggaggac     1920

aaaggcctgc cccatggcaa tgtctctgcc cggaaggtgc tcctggctcg ggagggggct     1980

gatgggagcc cgcccttcat caagctgagt gaccctgggg tcagccccgc tgtgttaagc     2040

ctggagatgc tcaccgacag gatcccctgg gtggcccccg agtgtctccg ggaggcgcag     2100

acacttagct tggaagctga caagtggggc ttcggcgcca cggtctggga agtgtttagt     2160

ggcgtcacca tgcccatcag tgccctggat cctgctaaga aactccaatt ttatgaggac     2220

cggcagcagc tgccggcccc caagtggaca gagctggccc tgctgattca acagtgcatg     2280

gcctatgagc cggtccagag gccctccttc cgagccgtca ttcgtgacct caatagcctc     2340

atctcttcag actatgagct cctctcagac cccacacctg gtgccctggc acctcgtgat     2400

gggctgtgga atggtgccca gctctatgcc tgccaagacc ccacgatctt cgaggagaga     2460

cacctcaagt acatctcaca gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc     2520

tatgacccgc taggcgacaa tacaggtgcc ctggtggccg tgaaacagct gcagcacagc     2580

gggccagacc agcagaggga ctttcagcgg gagattcaga tcctcaaagc actgcacagt     2640

gatttcattg tcaagtatcg tggtgtcagc tatggcccgg gccgccagag cctgcggctg     2700

gtcatggagt acctgcccag cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc     2760

ctcgatgcca gccgcctcct tctctattcc tcgcagatct gcaagggcat ggagtacctg     2820

ggctcccgcc gctgcgtgca ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag     2880

gcacacgtca agatcgctga cttcggccta gctaagctgc tgccgcttga caaagactac     2940

tacgtggtcc gcgagccagg ccagagcccc attttctggt atgcccccga atccctctcg     3000

gacaacatct tctctcgcca gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc     3060

ttcacctact gcgacaaaag ctgcagcccc tcggccgagt tcctgcggat gatgggatgt     3120

gagcgggatg tccccgccct ctgccgcctc ttggaactgc tggaggaggg ccagaggctg     3180

ccggcgcctc ctgcctgccc tgctgaggtt cacgagctca tgaagctgtg ctgggcccct     3240

agcccacagg accggccatc attcagcgcc ctgggccccc agctggacat gctgtggagc     3300

ggaagccggg ggtgtgagac tcatgccttc actgctcacc cagagggcaa acaccactcc     3360

ctgtcctttt catag                                                      3375


<210>  7
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  7
atggagaacg gatacaccta tgaagattat aagaacactg cagaatggct tctgtctcac       60

actaagcacc gacctcaagt tgcaataatc tgtggttctg gattaggagg tctgactgat      120

aaattaactc aggcccagat ctttgactac ggtgaaatcc ccaactttcc ccgaagtaca      180

gtgccaggtc atgctggccg actggtgttt gggttcctga atggcagggc ctgtgtgatg      240

atgcagggca ggttccacat gtatgaaggg tacccactct ggaaggtgac attcccagtg      300

agggttttcc accttctggg tgtggacacc ctggtagtca ccaatgcagc aggagggctg      360

aaccccaagt ttgaggttgg agatatcatg ctgatccgtg accatatcaa cctacctggt      420

ttcagtggtc agaaccctct cagagggccc aatgatgaaa ggtttggaga tcgtttccct      480

gccatgtctg atgcctacga ccggactatg aggcagaggg ctctcagtac ctggaaacaa      540

atgggggagc aacgtgagct acaggaaggc acctatgtga tggtggcagg ccccagcttt      600

gagactgtgg cagaatgtcg tgtgctgcag aagctgggag cagacgctgt tggcatgagt      660

acagtaccag aagttatcgt tgcacggcac tgtggacttc gagtctttgg cttctcactc      720

atcactaaca aggtcatcat ggattatgaa agcctggaga aggccaacca tgaagaagtc      780

ttagcagctg gcaaacaagc tgcacagaaa ttggaacagt ttgtctccat tcttatggcc      840

agcattccac tccctgacaa agccagttga                                       870


<210>  8
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcccaga cgcccgcctt cgacaagccc aaagtagaac tgcatgtcca cctagacgga       60

tccatcaagc ctgaaaccat cttatactat ggcaggagga gagggatcgc cctcccagct      120

aacacagcag aggggctgct gaacgtcatt ggcatggaca agccgctcac ccttccagac      180

ttcctggcca agtttgacta ctacatgcct gctatcgcgg gctgccggga ggctatcaaa      240

aggatcgcct atgagtttgt agagatgaag gccaaagagg gcgtggtgta tgtggaggtg      300

cggtacagtc cgcacctgct ggccaactcc aaagtggagc caatcccctg gaaccaggct      360

gaaggggacc tcaccccaga cgaggtggtg gccctagtgg gccagggcct gcaggagggg      420

gagcgagact tcggggtcaa ggcccggtcc atcctgtgct gcatgcgcca ccagcccaac      480

tggtccccca aggtggtgga gctgtgtaag aagtaccagc agcagaccgt ggtagccatt      540

gacctggctg gagatgagac catcccagga agcagcctct tgcctggaca tgtccaggcc      600

taccaggagg ctgtgaagag cggcattcac cgtactgtcc acgccgggga ggtgggctcg      660

gccgaagtag taaaagaggc tgtggacata ctcaagacag agcggctggg acacggctac      720

cacaccctgg aagaccaggc cctttataac aggctgcggc aggaaaacat gcacttcgag      780

atctgcccct ggtccagcta cctcactggt gcctggaagc cggacacgga gcatgcagtc      840

attcggctca aaaatgacca ggctaactac tcgctcaaca cagatgaccc gctcatcttc      900

aagtccaccc tggacactga ttaccagatg accaaacggg acatgggctt tactgaagag      960

gagtttaaaa ggctgaacat caatgcggcc aaatctagtt tcctcccaga agatgaaaag     1020

agggagcttc tcgacctgct ctataaagcc tatgggatgc caccttcagc ctctgcaggg     1080

cagaacctct ga                                                         1092


<210>  9
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcagcct ctttcccacc caccttggga ctcagttctg ccccagatga aattcagcac       60

ccacatatta aattttcaga atggaaattt aagctgttcc gggtgagatc ctttgaaaag      120

acacctgaag aagctcaaaa ggaaaagaag gattcctttg aggggaaacc ctctctggag      180

caatctccag cagtcctgga caaggctgat ggtcagaagc cagtcccaac tcagccattg      240

ttaaaagccc accctaagtt ttcaaagaaa tttcacgaca acgagaaagc aagaggcaaa      300

gcgatccatc aagccaacct tcgacatctc tgccgcatct gtgggaattc ttttagagct      360

gatgagcaca acaggagata tccagtccat ggtcctgtgg atggtaaaac cctaggcctt      420

ttacgaaaga aggaaaagag agctacttcc tggccggacc tcattgccaa ggttttccgg      480

atcgatgtga aggcagatgt tgactcgatc caccccactg agttctgcca taactgctgg      540

agcatcatgc acaggaagtt tagcagtgcc ccatgtgagg tttacttccc gaggaacgtg      600

accatggagt ggcaccccca cacaccatcc tgtgacatct gcaacactgc ccgtcgggga      660

ctcaagagga agagtcttca gccaaacttg cagctcagca aaaaactcaa aactgtgctt      720

gaccaagcaa gacaagcccg tcagcgcaag agaagagctc aggcaaggat cagcagcaag      780

gatgtcatga agaagatcgc caactgcagt aagatacatc ttagtaccaa gctccttgca      840

gtggacttcc cagagcactt tgtgaaatcc atctcctgcc agatctgtga acacattctg      900

gctgaccctg tggagaccaa ctgtaagcat gtcttttgcc gggtctgcat tctcagatgc      960

ctcaaagtca tgggcagcta ttgtccctct tgccgatatc catgcttccc tactgacctg     1020

gagagtccag tgaagtcctt tctgagcgtc ttgaattccc tgatggtgaa atgtccagca     1080

aaagagtgca atgaggaggt cagtttggaa aaatataatc accacatctc aagtcacaag     1140

gaatcaaaag agatttttgt gcacattaat aaagggggcc ggccccgcca acatcttctg     1200

tcgctgactc ggagagctca gaagcaccgg ctgagggagc tcaagctgca agtcaaagcc     1260

tttgctgaca aagaagaagg tggagatgtg aagtccgtgt gcatgacctt gttcctgctg     1320

gctctgaggg cgaggaatga gcacaggcaa gctgatgagc tggaggccat catgcaggga     1380

aagggctctg gcctgcagcc agctgtttgc ttggccatcc gtgtcaacac cttcctcagc     1440

tgcagtcagt accacaagat gtacaggact gtgaaagcca tcacagggag acagattttt     1500

cagcctttgc atgcccttcg gaatgctgag aaggtacttc tgccaggcta ccaccacttt     1560

gagtggcagc cacctctgaa gaatgtgtct tccagcactg atgttggcat tattgatggg     1620

ctgtctggac tatcatcctc tgtggatgat tacccagtgg acaccattgc aaagaggttc     1680

cgctatgatt cagctttggt gtctgctttg atggacatgg aagaagacat cttggaaggc     1740

atgagatccc aagaccttga tgattacctg aatggcccct tcactgtggt ggtgaaggag     1800

tcttgtgatg gaatgggaga cgtgagtgag aagcatggga gtgggcctgt agttccagaa     1860

aaggcagtcc gtttttcatt cacaatcatg aaaattacta ttgcccacag ctctcagaat     1920

gtgaaagtat ttgaagaagc caaacctaac tctgaactgt gttgcaagcc attgtgcctt     1980

atgctggcag atgagtctga ccacgagacg ctgactgcca tcctgagtcc tctcattgct     2040

gagagggagg ccatgaagag cagtgaatta atgcttgagc tgggaggcat tctccggact     2100

ttcaagttca tcttcagggg caccggctat gatgaaaaac ttgtgcggga agtggaaggc     2160

ctcgaggctt ctggctcagt ctacatttgt actctttgtg atgccacccg tctggaagcc     2220

tctcaaaatc ttgtcttcca ctctataacc agaagccatg ctgagaacct ggaacgttat     2280

gaggtctggc gttccaaccc ttaccatgag tctgtggaag aactgcggga tcgggtgaaa     2340

ggggtctcag ctaaaccttt cattgagaca gtcccttcca tagatgcact ccactgtgac     2400

attggcaatg cagctgagtt ctacaagatc ttccagctag agatagggga agtgtataag     2460

aatcccaatg cttccaaaga ggaaaggaaa aggtggcagg ccacactgga caagcatctc     2520

cggaagaaga tgaacctcaa accaatcatg aggatgaatg gcaactttgc caggaagctc     2580

atgaccaaag agactgtgga tgcagtttgt gagttaattc cttccgagga gaggcacgag     2640

gctctgaggg agctgatgga tctttacctg aagatgaaac cagtatggcg atcatcatgc     2700

cctgctaaag agtgcccaga atccctctgc cagtacagtt tcaattcaca gcgttttgct     2760

gagctccttt ctacgaagtt caagtatagg tatgagggaa aaatcaccaa ttattttcac     2820

aaaaccctgg cccatgttcc tgaaattatt gagagggatg gctccattgg ggcatgggca     2880

agtgagggaa atgagtctgg taacaaactg tttaggcgct tccggaaaat gaatgccagg     2940

cagtccaaat gctatgagat ggaagatgtc ctgaaacacc actggttgta cacctccaaa     3000

tacctccaga agtttatgaa tgctcataat gcattaaaaa cctctgggtt taccatgaac     3060

cctcaggcaa gcttagggga cccattaggc atagaggact ctctggaaag ccaagattca     3120

atggaatttt aa                                                         3132


<210>  10
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  10
atgtctctgc agatggtaac agtcagtaat aacatagcct taattcagcc aggcttctca       60

ctgatgaatt ttgatggaca agttttcttc tttggacaaa aaggctggcc caaaagatcc      120

tgccccactg gagttttcca tctggatgta aagcataacc atgtcaaact gaagcctaca      180

attttctcta aggattcctg ctacctccct cctcttcgct acccagccac ttgcacattc      240

aaaggcagct tggagtctga aaagcatcaa tacatcatcc atggagggaa aacaccaaac      300

aatgaggttt cagataagat ttatgtcatg tctattgttt gcaagaacaa caaaaaggtt      360

acttttcgct gcacagagaa agacttggta ggagatgttc ctgaagccag atatggtcat      420

tccattaatg tggtgtacag ccgagggaaa agtatgggtg ttctctttgg aggacgctca      480

tacatgcctt ctacccacag aaccacagaa aaatggaata gtgtagctga ctgcctgccc      540

tgtgttttcc tggtggattt tgaatttggg tgtgctacat catacattct tccagaactt      600

caggatgggc tatcttttca tgtctctatt gccaaaaatg acaccatcta tattttagga      660

ggacattcac ttgccaataa tatccggcct gccaacctgt acagaataag ggttgatctt      720

cccctgggta gcccagctgt gaattgcaca gtcttgccag gaggaatctc tgtctccagt      780

gcaatcctga ctcaaactaa caatgatgaa tttgttattg ttggtggcta tcagcttgaa      840

aatcaaaaaa gaatgatctg caacatcatc tctttagagg acaacaagat agaaattcgt      900

gagatggaga ccccagattg gaccccagac attaagcaca gcaagatatg gtttggaagc      960

aacatgggaa atggaactgt ttttcttggc ataccaggag acaataaaca agttgtttca     1020

gaaggattct atttctatat gttgaaatgt gctgaagatg atactaatga agagcagaca     1080

acattcacaa acagtcaaac atcaacagaa gatccagggg attccactcc ctttgaagac     1140

tctgaagaat tttgtttcag tgcagaagca aatagttttg atggtgatga tgaatttgac     1200

acctataatg aagatgatga agaagatgag tctgagacag gctactggat tacatgctgc     1260

cctacttgtg atgtggatat caacacttgg gtaccattct attcaactga gctcaacaaa     1320

cccgccatga tctactgctc tcatggggat gggcactggg tccatgctca gtgcatggat     1380

ctggcagaac gcacactcat ccatctgtca gcaggaagca acaagtatta ctgcaatgag     1440

catgtggaga tagcaagagc tctacacact ccccaaagag tcctaccctt aaaaaagcct     1500

ccaatgaaat ccctccgtaa aaaaggttct ggaaaaatct tgactcctgc caagaaatcc     1560

tttcttagaa ggttgtttga ttag                                            1584


<210>  11
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  12
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp 
1               5                   10                  15      


Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly 
            20                  25                  30          


Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe 
        35                  40                  45              


Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His 
    50                  55                  60                  


Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met 
65                  70                  75                  80  


Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val 
                85                  90                  95      


Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val 
            100                 105                 110         


Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp 
        115                 120                 125             


Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln 
    130                 135                 140                 


Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro 
145                 150                 155                 160 


Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser 
                165                 170                 175     


Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr 
            180                 185                 190         


Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val 
        195                 200                 205             


Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu 
    210                 215                 220                 


Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu 
225                 230                 235                 240 


Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn 
                245                 250                 255     


His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu 
            260                 265                 270         


Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala 
        275                 280                 285             


Ser 
    


<210>  13
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Gln Thr Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Thr Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Thr Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Thr Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Thr Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Thr 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Thr Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Thr Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Thr Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Thr Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ile Cys Pro Trp Ser Ser Tyr Leu Thr Gly Ala Trp 
            260                 265                 270         


Lys Pro Asp Thr Glu His Ala Val Ile Arg Leu Lys Asn Asp Gln Ala 
        275                 280                 285             


Asn Tyr Ser Leu Asn Thr Asp Asp Pro Leu Ile Phe Lys Ser Thr Leu 
    290                 295                 300                 


Asp Thr Asp Tyr Gln Met Thr Lys Arg Asp Met Gly Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Phe Lys Arg Leu Asn Ile Asn Ala Ala Lys Ser Ser Phe Leu Pro 
                325                 330                 335     


Glu Asp Glu Lys Arg Glu Leu Leu Asp Leu Leu Tyr Lys Ala Tyr Gly 
            340                 345                 350         


Met Pro Pro Ser Ala Ser Ala Gly Gln Asn Leu 
        355                 360             


<210>  14
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Ser Phe Pro Pro Thr Leu Gly Leu Ser Ser Ala Pro Asp 
1               5                   10                  15      


Glu Ile Gln His Pro His Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu 
            20                  25                  30          


Phe Arg Val Arg Ser Phe Glu Lys Thr Pro Glu Glu Ala Gln Lys Glu 
        35                  40                  45              


Lys Lys Asp Ser Phe Glu Gly Lys Pro Ser Leu Glu Gln Ser Pro Ala 
    50                  55                  60                  


Val Leu Asp Lys Ala Asp Gly Gln Lys Pro Val Pro Thr Gln Pro Leu 
65                  70                  75                  80  


Leu Lys Ala His Pro Lys Phe Ser Lys Lys Phe His Asp Asn Glu Lys 
                85                  90                  95      


Ala Arg Gly Lys Ala Ile His Gln Ala Asn Leu Arg His Leu Cys Arg 
            100                 105                 110         


Ile Cys Gly Asn Ser Phe Arg Ala Asp Glu His Asn Arg Arg Tyr Pro 
        115                 120                 125             


Val His Gly Pro Val Asp Gly Lys Thr Leu Gly Leu Leu Arg Lys Lys 
    130                 135                 140                 


Glu Lys Arg Ala Thr Ser Trp Pro Asp Leu Ile Ala Lys Val Phe Arg 
145                 150                 155                 160 


Ile Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys 
                165                 170                 175     


His Asn Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ala Pro Cys 
            180                 185                 190         


Glu Val Tyr Phe Pro Arg Asn Val Thr Met Glu Trp His Pro His Thr 
        195                 200                 205             


Pro Ser Cys Asp Ile Cys Asn Thr Ala Arg Arg Gly Leu Lys Arg Lys 
    210                 215                 220                 


Ser Leu Gln Pro Asn Leu Gln Leu Ser Lys Lys Leu Lys Thr Val Leu 
225                 230                 235                 240 


Asp Gln Ala Arg Gln Ala Arg Gln His Lys Arg Arg Ala Gln Ala Arg 
                245                 250                 255     


Ile Ser Ser Lys Asp Val Met Lys Lys Ile Ala Asn Cys Ser Lys Ile 
            260                 265                 270         


His Leu Ser Thr Lys Leu Leu Ala Val Asp Phe Pro Glu His Phe Val 
        275                 280                 285             


Lys Ser Ile Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val 
    290                 295                 300                 


Glu Thr Asn Cys Lys His Val Phe Cys Arg Val Cys Ile Leu Arg Cys 
305                 310                 315                 320 


Leu Lys Val Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe 
                325                 330                 335     


Pro Thr Asp Leu Glu Ser Pro Val Lys Ser Phe Leu Ser Val Leu Asn 
            340                 345                 350         


Ser Leu Met Val Lys Cys Pro Ala Lys Glu Cys Asn Glu Glu Val Ser 
        355                 360                 365             


Leu Glu Lys Tyr Asn His His Ile Ser Ser His Lys Glu Ser Lys Glu 
    370                 375                 380                 


Ile Phe Val His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu 
385                 390                 395                 400 


Ser Leu Thr Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Leu 
                405                 410                 415     


Gln Val Lys Ala Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ser 
            420                 425                 430         


Val Cys Met Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His 
        435                 440                 445             


Arg Gln Ala Asp Glu Leu Glu Ala Ile Met Gln Gly Lys Gly Ser Gly 
    450                 455                 460                 


Leu Gln Pro Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser 
465                 470                 475                 480 


Cys Ser Gln Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly 
                485                 490                 495     


Arg Gln Ile Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val 
            500                 505                 510         


Leu Leu Pro Gly Tyr His His Phe Glu Trp Gln Pro Pro Leu Lys Asn 
        515                 520                 525             


Val Ser Ser Ser Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu 
    530                 535                 540                 


Ser Ser Ser Val Asp Asp Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe 
545                 550                 555                 560 


Arg Tyr Asp Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp 
                565                 570                 575     


Ile Leu Glu Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly 
            580                 585                 590         


Pro Phe Thr Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val 
        595                 600                 605             


Ser Glu Lys His Gly Ser Gly Pro Val Val Pro Glu Lys Ala Val Arg 
    610                 615                 620                 


Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala His Ser Ser Gln Asn 
625                 630                 635                 640 


Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser Glu Leu Cys Cys Lys 
                645                 650                 655     


Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr 
            660                 665                 670         


Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser 
        675                 680                 685             


Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg Thr Phe Lys Phe Ile 
    690                 695                 700                 


Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly 
705                 710                 715                 720 


Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Ala Thr 
                725                 730                 735     


Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser 
            740                 745                 750         


His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr 
        755                 760                 765             


His Glu Ser Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala 
    770                 775                 780                 


Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp 
785                 790                 795                 800 


Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly 
                805                 810                 815     


Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp 
            820                 825                 830         


Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys Met Asn Leu Lys Pro 
        835                 840                 845             


Ile Met Arg Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Lys Glu 
    850                 855                 860                 


Thr Val Asp Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu 
865                 870                 875                 880 


Ala Leu Arg Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp 
                885                 890                 895     


Arg Ser Ser Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr 
            900                 905                 910         


Ser Phe Asn Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys 
        915                 920                 925             


Tyr Arg Tyr Glu Gly Lys Ile Thr Asn Tyr Phe His Lys Thr Leu Ala 
    930                 935                 940                 


His Val Pro Glu Ile Ile Glu Arg Asp Gly Ser Ile Gly Ala Trp Ala 
945                 950                 955                 960 


Ser Glu Gly Asn Glu Ser Gly Asn Lys Leu Phe Arg Arg Phe Arg Lys 
                965                 970                 975     


Met Asn Ala Arg Gln Ser Lys Cys Tyr Glu Met Glu Asp Val Leu Lys 
            980                 985                 990         


His His Trp Leu Tyr Thr Ser Lys  Tyr Leu Gln Lys Phe  Met Asn Ala 
        995                 1000                 1005             


His Asn  Ala Leu Lys Thr Ser  Gly Phe Thr Met Asn  Pro Gln Ala 
    1010                 1015                 1020             


Ser Leu  Gly Asp Pro Leu Gly  Ile Glu Asp Ser Leu  Glu Ser Gln 
    1025                 1030                 1035             


Asp Ser  Met Glu Phe 
    1040             


<210>  15
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu 
        35                  40                  45              


Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe 
65                  70                  75                  80  


Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile 
            100                 105                 110         


Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn 
        275                 280                 285             


Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu 
            340                 345                 350         


Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro 
                485                 490                 495     


Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  16
<211>  4368
<212>  DNA
<213>  Homo sapiens

<400>  16
atgtccgact cgtgggtccc gaactccgcc tcgggccagg acccaggggg ccgccggagg       60

gcctgggccg agctgctggc gggaagggtc aagagggaaa aatataatcc tgaaagggca      120

cagaaattaa aggaatcagc tgtgcgcctc ctgcgaagcc atcaggacct gaatgccctt      180

ttgcttgagg tagaaggtcc actgtgtaaa aaattgtctc tcagcaaagt gattgactgt      240

gacagttctg aggcctatgc taatcattct agttcattta taggctctgc tttgcaggat      300

caagcctcaa ggctgggggt tcccgtgggt attctctcag ccgggatggt tgcctctagc      360

gtgggacaga tctgcacggc tccagcggag accagtcacc ctgtgctgct gactgtggag      420

cagagaaaga agctgtcttc cctgttagag tttgctcagt atttattggc acacagtatg      480

ttctcccgtc tttccttctg tcaagaatta tggaaaatac agagttcttt gttgcttgaa      540

gcggtgtggc atcttcacgt acaaggcatt gtgagcctgc aagagctgct ggaaagccat      600

cccgacatgc atgctgtggg atcgtggctc ttcaggaatc tgtgctgcct ttgtgaacag      660

atggaagcat cctgccagca tgctgacgtc gccagggcca tgctttctga ttttgttcaa      720

atgtttgttt tgaggggatt tcagaaaaac tcagatctga gaagaactgt ggagcctgaa      780

aaaatgccgc aggtcacggt tgatgtactg cagagaatgc tgatttttgc acttgacgct      840

ttggctgctg gagtacagga ggagtcctcc actcacaaga tcgtgaggtg ctggttcgga      900

gtgttcagtg gacacacgct tggcagtgta atttccacag atcctctgaa gaggttcttc      960

agtcataccc tgactcagat actcactcac agccctgtgc tgaaagcatc tgatgctgtt     1020

cagatgcaga gagagtggag ctttgcgcgg acacaccctc tgctcacctc actgtaccgc     1080

aggctctttg tgatgctgag tgcagaggag ttggttggcc atttgcaaga agttctggaa     1140

acgcaggagg ttcactggca gagagtgctc tcctttgtgt ctgccctggt tgtctgcttt     1200

ccagaagcgc agcagctgct tgaagactgg gtggcgcgtt tgatggccca ggcattcgag     1260

agctgccagc tggacagcat ggtcactgcg ttcctggttg tgcgccaggc agcactggag     1320

ggcccctctg cgttcctgtc atatgcagac tggttcaagg cctcctttgg gagcacacga     1380

ggctaccatg gctgcagcaa gaaggccctg gtcttcctgt ttacgttctt gtcagaactc     1440

gtgccttttg agtctccccg gtacctgcag gtgcacattc tccacccacc cctggttccc     1500

agcaagtacc gctccctcct cacagactac atctcattgg ccaagacacg gctggccgac     1560

ctcaaggttt ctatagaaaa catgggactc tacgaggatt tgtcatcagc tggggacatt     1620

actgagcccc acagccaagc tcttcaggat gttgaaaagg ccatcatggt gtttgagcat     1680

acggggaaca tcccagtcac cgtcatggag gccagcatat tcaggaggcc ttactacgtg     1740

tcccacttcc tccccgccct gctcacacct cgagtgctcc ccaaagtccc tgactcccgt     1800

gtggcgttta tagagtctct gaagagagca gataaaatcc ccccatctct gtactccacc     1860

tactgccagg cctgctctgc tgctgaagag aagccagaag atgcagccct gggagtgagg     1920

gcagaaccca actctgctga ggagcccctg ggacagctca cagctgcact gggagagctg     1980

agagcctcca tgacagaccc cagccagcgt gatgttatat cggcacaggt ggcagtgatt     2040

tctgaaagac tgagggctgt cctgggccac aatgaggatg acagcagcgt tgagatatca     2100

aagattcagc tcagcatcaa cacgccgaga ctggagccac gggaacacat tgctgtggac     2160

ctcctgctga cgtctttctg tcagaacctg atggctgcct ccagtgtcgc tcccccggag     2220

aggcagggtc cctgggctgc cctcttcgtg aggaccatgt gtggacgtgt gctccctgca     2280

gtgctcaccc ggctctgcca gctgctccgt caccagggcc cgagcctgag tgccccacat     2340

gtgctggggt tggctgccct ggccgtgcac ctgggtgagt ccaggtctgc gctcccagag     2400

gtggatgtgg gtcctcctgc acctggtgct ggccttcctg tccctgcgct ctttgacagc     2460

ctcctgacct gtaggacgag ggattccttg ttcttctgcc tgaaattttg tacagcagca     2520

atttcttact ctctctgcaa gttttcttcc cagtcacgag atactttgtg cagctgctta     2580

tctccaggcc ttattaaaaa gtttcagttc ctcatgttca gattgttctc agaggcccga     2640

cagcctcttt ctgaggagga cgtagccagc ctttcctgga gacccttgca ccttccttct     2700

gcagactggc agagagctgc cctctctctc tggacacaca gaaccttccg agaggtgttg     2760

aaagaggaag atgttcactt aacttaccaa gactggttac acctggagct ggaaattcaa     2820

cctgaagctg atgctctttc agatactgaa cggcaggact tccaccagtg ggcgatccat     2880

gagcactttc tccctgagtc ctcggcttca gggggctgtg acggagacct gcaggctgcg     2940

tgtaccattc ttgtcaacgc actgatggat ttccaccaaa gctcaaggag ttatgaccac     3000

tcagaaaatt ctgatttggt ctttggtggc cgcacaggaa atgaggatat tatttccaga     3060

ttgcaggaga tggtagctga cctggagctg cagcaagacc tcatagtgcc tctcggccac     3120

accccttccc aggagcactt cctctttgag attttccgca gacggctcca ggctctgaca     3180

agcgggtgga gcgtggctgc cagccttcag agacagaggg agctgctaat gtacaaacgg     3240

atcctcctcc gcctgccttc gtctgtcctc tgcggcagca gcttccaggc agaacagccc     3300

atcactgcca gatgcgagca gttcttccac ttggtcaact ctgagatgag aaacttctgc     3360

tcccacggag gtgccctgac acaggacatc actgcccact tcttcagggg cctcctgaac     3420

gcctgtctgc ggagcagaga cccctccctg atggtcgact tcatactggc caagtgccag     3480

acgaaatgcc ccttaatttt gacctctgct ctggtgtggt ggccgagcct ggagcctgtg     3540

ctgctctgcc ggtggaggag acactgccag agcccgctgc cccgggaact gcagaagcta     3600

caagaaggcc ggcagtttgc cagcgatttc ctctcccctg aggctgcctc cccagcaccc     3660

aacccggact ggctctcagc tgctgcactg cactttgcga ttcaacaagt cagggaagaa     3720

aacatcagga agcagctaaa gaagctggac tgcgagagag aggagctatt ggttttcctt     3780

ttcttcttct ccttgatggg cctgctgtcg tcacatctga cctcaaatag caccacagac     3840

ctgccaaagg ctttccacgt ttgtgcagca atcctcgagt gtttagagaa gaggaagata     3900

tcctggctgg cactctttca gttgacagag agtgacctca ggctggggcg gctcctcctc     3960

cgtgtggccc cggatcagca caccaggctg ctgcctttcg ctttttacag tcttctctcc     4020

tacttccatg aagacgcggc catcagggaa gaggccttcc tgcatgttgc tgtggacatg     4080

tacttgaagc tggtccagct cttcgtggct ggggatacaa gcacagtttc acctccagct     4140

ggcaggagcc tggagctcaa gggtcagggc aaccccgtgg aactgataac aaaagctcgt     4200

ctttttctgc tgcagttaat acctcggtgc ccgaaaaaga gcttctcaca cgtggcagag     4260

ctgctggctg atcgtgggga ctgcgaccca gaggtgagcg ccgccctcca gagcagacag     4320

caggctgccc ctgacgctga cctgtcccag gagcctcatc tcttctga                  4368


<210>  17
<211>  1677
<212>  DNA
<213>  Homo sapiens

<400>  17
atggctcaag attcagtaga tctttcttgt gattatcagt tttggatgca gaagctttct       60

gtatgggatc aggcttccac tttggaaacc cagcaagaca cctgtcttca cgtggctcag      120

ttccaggagt tcctaaggaa gatgtatgaa gccttgaaag agatggattc taatacagtc      180

attgaaagat tccccacaat tggtcaactg ttggcaaaag cttgttggaa tccttttatt      240

ttagcatatg atgaaagcca aaaaattcta atatggtgct tatgttgtct aattaacaaa      300

gaaccacaga attctggaca atcaaaactt aactcctgga tacagggtgt attatctcat      360

atactttcag cactcagatt tgataaagaa gttgctcttt tcactcaagg tcttgggtat      420

gcacctatag attactatcc tggtttgctt aaaaatatgg ttttatcatt agcgtctgaa      480

ctcagagaga atcatcttaa tggatttaac actcaaaggc gaatggctcc cgagcgagtg      540

gcgtccctgt cacgagtttg tgtcccactt attaccctga cagatgttga ccccctggtg      600

gaggctctcc tcatctgtca tggacgtgaa cctcaggaaa tcctccagcc agagttcttt      660

gaggctgtaa acgaggccat tttgctgaag aagatttctc tccccatgtc agctgtagtc      720

tgcctctggc ttcggcacct tcccagcctt gaaaaagcaa tgctgcatct ttttgaaaag      780

ctaatctcca gtgagagaaa ttgtctgaga aggatcgaat gctttataaa agattcatcg      840

ctgcctcaag cagcctgcca ccctgccata ttccgggttg ttgatgagat gttcaggtgt      900

gcactcctgg aaaccgatgg ggccctggaa atcatagcca ctattcaggt gtttacgcag      960

tgctttgtag aagctctgga gaaagcaagc aagcagctgc ggtttgcact caagacctac     1020

tttccttaca cttctccatc tcttgccatg gtgctgctgc aagaccctca agatatccct     1080

cggggacact ggctccagac actgaagcat atttctgaac tgctcagaga agcagttgaa     1140

gaccagactc atgggtcctg cggaggtccc tttgagagct ggttcctgtt cattcacttc     1200

ggaggatggg ctgagatggt ggcagagcaa ttactgatgt cggcagccga accccccacg     1260

gccctgctgt ggctcttggc cttctactac ggcccccgtg atgggaggca gcagagagca     1320

cagactatgg tccaggtgaa ggccgtgctg ggccacctcc tggcaatgtc cagaagcagc     1380

agcctctcag cccaggacct gcagacggta gcaggacagg gcacagacac agacctcaga     1440

gctcctgcac aacagctgat caggcacctt ctcctcaact tcctgctctg ggctcctgga     1500

ggccacacga tcgcctggga tgtcatcacc ctgatggctc acactgctga gataactcac     1560

gagatcattg gctttcttga ccagaccttg tacagatgga atcgtcttgg cattgaaagc     1620

cctagatcag aaaaactggc ccgagagctc cttaaagagc tgcgaactca agtctag        1677


<210>  18
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  18
atggcgacac cggacgcggg gctccctggg gctgagggcg tggagccggc gccctgggcg       60

cagctggagg cccccgcccg cctcctgctg caggcgctgc aggcggggcc tgagggggcg      120

cggcgcggcc tgggggtgct ccgggcgctg ggcagccgcg gctgggagcc cttcgactgg      180

ggtcgcttgc tcgaggccct gtgccgggag gagccggtcg tgcaggggcc tgacggccgt      240

ctggagctga aaccactgtt gctgcgattg ccccggatat gccagaggaa cctgatgtcc      300

ctgctgatgg ccgttcggcc atcgctgccg gaaagtgggc tcctctctgt gctgcagatt      360

gcccagcagg acctagcccc tgacccagat gcctggctcc gtgccctggg ggaattgctg      420

cgaagggatt tgggggtggg gacctccatg gagggagctt ctccactgtc tgaaagatgc      480

cagagacagc tccaaagtct atgtaggggg ctgggcctgg ggggcaggag gttgaaatcc      540

ccccaggctc cagaccctga agaagaggag aacagggact cccagcagcc tgggaaacgc      600

agaaaggact cagaggaaga ggctgccagt cctgagggga agagggtccc caaaagatta      660

cggtgttggg aagaggaaga agatcatgag aaggagagac ccgaacataa gtcactggaa      720

tccctggcag atggaggaag tgcatctcct attaaggacc agcctgtcat ggcagttaag      780

actggcgagg acggttcgaa tctggatgat gctaaaggtc tggctgagag tttggagttg      840

cccaaagcta tccaggacca gcttcccagg ctgcagcagc tgctgaagac cttggaggag      900

gggttagagg gattggagga tgccccccca gttgagctac agcttcttca cgaatgtagt      960

cccagccaga tggacttgct gtgtgcccag ctgcagctcc ctcagctctc agacctcggt     1020

ctcctgcggc tctgcacctg gctgctggcc ctttcacctg atctcagcct cagcaatgct     1080

actgtgctga ccagaagcct ctttcttgga cggatcctct ccttgacttc ctcagcctcc     1140

cgcctgctta caactgccct gacctccttc tgtgccaaat atacataccc tgtctgcagc     1200

gccctccttg accctgtgct ccaggcccca ggcacaggtc ctgctcaaac agagttactg     1260

tgttgccttg tgaagatgga gtccctggag ccagatgcac aggttctaat gctgggacag     1320

atcttggagc tgccctggaa ggaggaaact ttcttggtgt tgcagtcact cctagagcgg     1380

caggtggaga tgacccctga gaagttcagt gtcttaatgg agaagctctg taaaaagggg     1440

ctggcagcca ccacctccat ggcctatgcc aagctcatgc tgacagtgat gaccaagtat     1500

caggctaaca tcactgagac ccagaggctg ggcctggcta tggccctaga acctaacacc     1560

accttcctga ggaagtccct gaaggccgcc ttgaaacatt tgggcccctg a              1611


<210>  19
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  19
atggaatccc ttctgcagca cctggatcgc ttttccgagc ttctggcggt ctcaagcact       60

acctacgtca gcacctggga ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac      120

ctgcgccaca tccatcggcg ctttggtcgg catggcccca ttcgcacggc tctggagcgg      180

cggctgcaca accagtggag gcaagagggc ggctttgggc ggggtccagt tccgggatta      240

gcgaacttcc aggccctcgg tcactgtgac gtcctgctct ctctgcgcct gctggagaac      300

cgggccctcg gggatgcagc tcgttaccac ctggtgcagc aactctttcc cggcccgggc      360

gtccgggacg ccgatgagga gacactccaa gagagcctgg cccgccttgc ccgccggcgg      420

tctgcggtgc acatgctgcg cttcaatggc tatagagaga acccaaatct ccaggaggac      480

tctctgatga agacccaggc ggagctgctg ctggagcgtc tgcaggaggt ggggaaggcc      540

gaagcggagc gtcccgccag gtttctcagc agcctgtggg agcgcttgcc tcagaacaac      600

ttcctgaagg tgatagcggt ggcgctgttg cagccgcctt tgtctcgtcg gccccaagaa      660

gagttggaac ccggcatcca caaatcacct ggagagggga gccaagtgct agtccactgg      720

cttctgggga attcggaagt ctttgctgcc ttttgtcgcg ccctcccagc cgggcttttg      780

actttagtga ctagccgcca cccagcgctg tctcctgtct atctgggtct gctaacagac      840

tggggtcaac gtttgcacta tgaccttcag aaaggcattt gggttggaac tgagtcccaa      900

gatgtgccct gggaggagtt gcacaatagg tttcaaagcc tctgtcaggc ccctccacct      960

ctgaaagata aagttctaac tgccctggag acctgtaaag cgcaggatgg agattttgaa     1020

gtacctggtc ttagcatctg gacagacctc ttattagctc ttcgtagtgg tgcatttagg     1080

aaaagacaag ttttgggtct cagcgcaggc ctcagttctg tatag                     1125


<210>  20
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  20
atgtcccgcc agaccacctc tgtgggctcc agctgcctgg acctgtggag ggaaaagaat       60

gaccggctcg ttcgacaggc caaggtggct cagaactccg gtctgactct gaggcgacag      120

cagttggctc aggatgcact ggaagggctc agagggctcc tccatagtct gcaagggctc      180

cctgcagctg ttcctgttct tcccttggag ctgactgtca cctgcaactt cattatcctg      240

agggcaagct tggcccaggg tttcacagag gatcaggccc aggatatcca gcggagccta      300

gagagagtgc tggagacaca ggagcagcag gggcccaggt tggaacaggg gctcagggag      360

ctgtgggact ctgtccttcg tgcttcctgc cttctgccgg agctgctgtc tgccctgcac      420

cgcctggttg gcctgcaggc tgccctctgg ttgagtgctg accgtcttgg ggacctggcc      480

ttgttactag agaccctgaa tggcagccag agtggagcct ctaaggatct gctgttactt      540

ctgaaaactt ggagtccccc agctgaggaa ttagatgctc cattgaccct gcaggatgcc      600

cagggattga aggatgtcct cctgacagca tttgcctacc gccaaggtct ccaggagctg      660

atcacaggga acccagacaa ggcactaagc agccttcatg aagcggcctc aggcctgtgt      720

ccacggcctg tgttggtcca ggtgtacaca gcactggggt cctgtcaccg taagatggga      780

aatccacaga gagcactgtt gtacttggtt gcagccctga aagagggatc agcctggggt      840

cctccacttc tggaggcctc taggctctat cagcaactgg gggacacaac agcagagctg      900

gagagtctgg agctgctagt tgaggccttg aatgtcccat gcagttccaa agccccgcag      960

tttctcattg aggtagaatt actactgcca ccacctgacc tagcctcacc ccttcattgt     1020

ggcactcaga gccagaccaa gcacatacta gcaagcaggt gcctacagac ggggagggca     1080

ggagacgctg cagagcatta cttggacctg ctggccctgt tgctggatag ctcggagcca     1140

aggttctccc cacccccctc ccctccaggg ccctgtatgc ctgaggtgtt tttggaggca     1200

gcggtagcac tgatccaggc aggcagagcc caagatgcct tgactctatg tgaggagttg     1260

ctcagccgca catcatctct gctacccaag atgtcccggc tgtgggaaga tgccagaaaa     1320

ggaaccaagg aactgccata ctgcccactc tgggtctctg ccacccacct gcttcagggc     1380

caggcctggg ttcaactggg tgcccaaaaa gtggcaatta gtgaatttag caggtgcctc     1440

gagctgctct tccgggccac acctgaggaa aaagaacaag gggcagcttt caactgtgag     1500

cagggatgta agtcagatgc ggcactgcag cagcttcggg cagccgccct aattagtcgt     1560

ggactggaat gggtagccag cggccaggat accaaagcct tacaggactt cctcctcagt     1620

gtgcagatgt gcccaggtaa tcgagacact tactttcacc tgcttcagac tctgaagagg     1680

ctagatcgga gggatgaggc cactgcactc tggtggaggc tggaggccca aactaagggg     1740

tcacatgaag atgctctgtg gtctctcccc ctgtacctag aaagctattt gagctggatc     1800

cgtccctctg atcgtgacgc cttccttgaa gaatttcgga catctctgcc aaagtcttgt     1860

gacctgtag                                                             1869


<210>  21
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly 
1               5                   10                  15      


Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg 
            20                  25                  30          


Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val 
        35                  40                  45              


Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val 
    50                  55                  60                  


Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys 
65                  70                  75                  80  


Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser 
                85                  90                  95      


Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu 
            100                 105                 110         


Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro 
        115                 120                 125             


Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys 
    130                 135                 140                 


Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met 
145                 150                 155                 160 


Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser 
            180                 185                 190         


Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser 
        195                 200                 205             


Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser 
    210                 215                 220                 


Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln 
225                 230                 235                 240 


Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr 
                245                 250                 255     


Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg 
            260                 265                 270         


Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu 
        275                 280                 285             


Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly 
    290                 295                 300                 


His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe 
305                 310                 315                 320 


Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala 
                325                 330                 335     


Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His 
            340                 345                 350         


Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala 
        355                 360                 365             


Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val 
    370                 375                 380                 


His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe 
385                 390                 395                 400 


Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala 
                405                 410                 415     


Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu 
            420                 425                 430         


Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr 
        435                 440                 445             


Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly 
    450                 455                 460                 


Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu 
465                 470                 475                 480 


Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro 
                485                 490                 495     


Pro Leu Val Pro Ser Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser 
            500                 505                 510         


Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met 
        515                 520                 525             


Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His 
    530                 535                 540                 


Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His 
545                 550                 555                 560 


Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg 
                565                 570                 575     


Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val 
            580                 585                 590         


Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys 
        595                 600                 605             


Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala 
    610                 615                 620                 


Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg 
625                 630                 635                 640 


Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala 
                645                 650                 655     


Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val 
            660                 665                 670         


Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu 
        675                 680                 685             


Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu 
    690                 695                 700                 


Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Ile Ala Val Asp 
705                 710                 715                 720 


Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val 
                725                 730                 735     


Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr 
            740                 745                 750         


Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu 
        755                 760                 765             


Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu 
    770                 775                 780                 


Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu 
785                 790                 795                 800 


Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala 
                805                 810                 815     


Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe 
            820                 825                 830         


Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe 
        835                 840                 845             


Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu 
    850                 855                 860                 


Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg 
865                 870                 875                 880 


Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu 
                885                 890                 895     


His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr 
            900                 905                 910         


His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr 
        915                 920                 925             


Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp 
    930                 935                 940                 


Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His 
945                 950                 955                 960 


Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp 
                965                 970                 975     


Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His 
            980                 985                 990         


Gln Ser Ser Arg Ser Tyr Asp His  Ser Glu Asn Ser Asp  Leu Val Phe 
        995                 1000                 1005             


Gly Gly  Arg Thr Gly Asn Glu  Asp Ile Ile Ser Arg  Leu Gln Glu 
    1010                 1015                 1020             


Met Val  Ala Asp Leu Glu Leu  Gln Gln Asp Leu Ile  Val Pro Leu 
    1025                 1030                 1035             


Gly His  Thr Pro Ser Gln Glu  His Phe Leu Phe Glu  Ile Phe Arg 
    1040                 1045                 1050             


Arg Arg  Leu Gln Ala Leu Thr  Ser Gly Trp Ser Val  Ala Ala Ser 
    1055                 1060                 1065             


Leu Gln  Arg Gln Arg Glu Leu  Leu Met Tyr Lys Arg  Ile Leu Leu 
    1070                 1075                 1080             


Arg Leu  Pro Ser Ser Val Leu  Cys Gly Ser Ser Phe  Gln Ala Glu 
    1085                 1090                 1095             


Gln Pro  Ile Thr Ala Arg Cys  Glu Gln Phe Phe His  Leu Val Asn 
    1100                 1105                 1110             


Ser Glu  Met Arg Asn Phe Cys  Ser His Gly Gly Ala  Leu Thr Gln 
    1115                 1120                 1125             


Asp Ile  Thr Ala His Phe Phe  Arg Gly Leu Leu Asn  Ala Cys Leu 
    1130                 1135                 1140             


Arg Ser  Arg Asp Pro Ser Leu  Met Val Asp Phe Ile  Leu Ala Lys 
    1145                 1150                 1155             


Cys Gln  Thr Lys Cys Pro Leu  Ile Leu Thr Ser Ala  Leu Val Trp 
    1160                 1165                 1170             


Trp Pro  Ser Leu Glu Pro Val  Leu Leu Cys Arg Trp  Arg Arg His 
    1175                 1180                 1185             


Cys Gln  Ser Pro Leu Pro Arg  Glu Leu Gln Lys Leu  Gln Glu Gly 
    1190                 1195                 1200             


Arg Gln  Phe Ala Ser Asp Phe  Leu Ser Pro Glu Ala  Ala Ser Pro 
    1205                 1210                 1215             


Ala Pro  Asn Pro Asp Trp Leu  Ser Ala Ala Ala Leu  His Phe Ala 
    1220                 1225                 1230             


Ile Gln  Gln Val Arg Glu Glu  Asn Ile Arg Lys Gln  Leu Lys Lys 
    1235                 1240                 1245             


Leu Asp  Cys Glu Arg Glu Glu  Leu Leu Val Phe Leu  Phe Phe Phe 
    1250                 1255                 1260             


Ser Leu  Met Gly Leu Leu Ser  Ser His Leu Thr Ser  Asn Ser Thr 
    1265                 1270                 1275             


Thr Asp  Leu Pro Lys Ala Phe  His Val Cys Ala Ala  Ile Leu Glu 
    1280                 1285                 1290             


Cys Leu  Glu Lys Arg Lys Ile  Ser Trp Leu Ala Leu  Phe Gln Leu 
    1295                 1300                 1305             


Thr Glu  Ser Asp Leu Arg Leu  Gly Arg Leu Leu Leu  Arg Val Ala 
    1310                 1315                 1320             


Pro Asp  Gln His Thr Arg Leu  Leu Pro Phe Ala Phe  Tyr Ser Leu 
    1325                 1330                 1335             


Leu Ser  Tyr Phe His Glu Asp  Ala Ala Ile Arg Glu  Glu Ala Phe 
    1340                 1345                 1350             


Leu His  Val Ala Val Asp Met  Tyr Leu Lys Leu Val  Gln Leu Phe 
    1355                 1360                 1365             


Val Ala  Gly Asp Thr Ser Thr  Val Ser Pro Pro Ala  Gly Arg Ser 
    1370                 1375                 1380             


Leu Glu  Leu Lys Gly Gln Gly  Asn Pro Val Glu Leu  Ile Thr Lys 
    1385                 1390                 1395             


Ala Arg  Leu Phe Leu Leu Gln  Leu Ile Pro Arg Cys  Pro Lys Lys 
    1400                 1405                 1410             


Ser Phe  Ser His Val Ala Glu  Leu Leu Ala Asp Arg  Gly Asp Cys 
    1415                 1420                 1425             


Asp Pro  Glu Val Ser Ala Ala  Leu Gln Ser Arg Gln  Gln Ala Ala 
    1430                 1435                 1440             


Pro Asp  Ala Asp Leu Ser Gln  Glu Pro His Leu Phe  
    1445                 1450                 1455 


<210>  22
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met 
1               5                   10                  15      


Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln 
            20                  25                  30          


Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met 
        35                  40                  45              


Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe 
    50                  55                  60                  


Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile 
65                  70                  75                  80  


Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys 
                85                  90                  95      


Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser 
            100                 105                 110         


Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp 
        115                 120                 125             


Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp 
    130                 135                 140                 


Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu 
145                 150                 155                 160 


Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala 
                165                 170                 175     


Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr 
            180                 185                 190         


Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly 
        195                 200                 205             


Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn 
    210                 215                 220                 


Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val 
225                 230                 235                 240 


Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His 
                245                 250                 255     


Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile 
            260                 265                 270         


Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro 
        275                 280                 285             


Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu 
    290                 295                 300                 


Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln 
305                 310                 315                 320 


Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala 
                325                 330                 335     


Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu 
            340                 345                 350         


Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu 
        355                 360                 365             


Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His 
    370                 375                 380                 


Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe 
385                 390                 395                 400 


Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala 
                405                 410                 415     


Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro 
            420                 425                 430         


Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala 
        435                 440                 445             


Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala 
    450                 455                 460                 


Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg 
465                 470                 475                 480 


Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu 
                485                 490                 495     


Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met 
            500                 505                 510         


Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln 
        515                 520                 525             


Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu 
    530                 535                 540                 


Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val 
545                 550                 555             


<210>  23
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro 
1               5                   10                  15      


Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala 
            20                  25                  30          


Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg 
        35                  40                  45              


Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu 
    50                  55                  60                  


Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg 
65                  70                  75                  80  


Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg 
                85                  90                  95      


Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser 
            100                 105                 110         


Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp 
        115                 120                 125             


Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu 
    130                 135                 140                 


Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys 
145                 150                 155                 160 


Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg 
                165                 170                 175     


Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg 
            180                 185                 190         


Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala 
        195                 200                 205             


Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu 
    210                 215                 220                 


Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val 
                245                 250                 255     


Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys 
            260                 265                 270         


Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu 
        275                 280                 285             


Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly 
    290                 295                 300                 


Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser 
305                 310                 315                 320 


Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu 
                325                 330                 335     


Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser 
            340                 345                 350         


Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe 
        355                 360                 365             


Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr 
    370                 375                 380                 


Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser 
385                 390                 395                 400 


Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln 
                405                 410                 415     


Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp 
            420                 425                 430         


Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu 
        435                 440                 445             


Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met 
    450                 455                 460                 


Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly 
465                 470                 475                 480 


Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val 
                485                 490                 495     


Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu 
            500                 505                 510         


Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys 
        515                 520                 525             


Ala Ala Leu Lys His Leu Gly Pro 
    530                 535     


<210>  24
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser Glu Leu Leu Ala 
1               5                   10                  15      


Val Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro Ala Thr Val Arg 
            20                  25                  30          


Arg Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile His Arg Arg Phe 
        35                  40                  45              


Gly Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg Arg Leu His Asn 
    50                  55                  60                  


Gln Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro Val Pro Gly Leu 
65                  70                  75                  80  


Ala Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu Leu Ser Leu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg Tyr His Leu Val 
            100                 105                 110         


Gln Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala Asp Glu Glu Thr 
        115                 120                 125             


Leu Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg Ser Ala Val His 
    130                 135                 140                 


Met Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn Leu Gln Glu Asp 
145                 150                 155                 160 


Ser Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu Arg Leu Gln Glu 
                165                 170                 175     


Val Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe Leu Ser Ser Leu 
            180                 185                 190         


Trp Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val Ile Ala Val Ala 
        195                 200                 205             


Leu Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu Glu Leu Glu Pro 
    210                 215                 220                 


Gly Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val Leu Val His Trp 
225                 230                 235                 240 


Leu Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys Arg Ala Leu Pro 
                245                 250                 255     


Ala Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro Ala Leu Ser Pro 
            260                 265                 270         


Val Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg Leu His Tyr Asp 
        275                 280                 285             


Leu Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln Asp Val Pro Trp 
    290                 295                 300                 


Glu Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln Ala Pro Pro Pro 
305                 310                 315                 320 


Leu Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys Lys Ala Gln Asp 
                325                 330                 335     


Gly Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr Asp Leu Leu Leu 
            340                 345                 350         


Ala Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val Leu Gly Leu Ser 
        355                 360                 365             


Ala Gly Leu Ser Ser Val 
    370                 


<210>  25
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp 
1               5                   10                  15      


Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn 
            20                  25                  30          


Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu 
        35                  40                  45              


Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val 
    50                  55                  60                  


Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu 
65                  70                  75                  80  


Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile 
                85                  90                  95      


Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro 
            100                 105                 110         


Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala 
        115                 120                 125             


Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly 
    130                 135                 140                 


Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala 
145                 150                 155                 160 


Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp 
                165                 170                 175     


Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp 
            180                 185                 190         


Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu 
        195                 200                 205             


Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn 
    210                 215                 220                 


Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys 
225                 230                 235                 240 


Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His 
                245                 250                 255     


Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala 
            260                 265                 270         


Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg 
        275                 280                 285             


Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu 
    290                 295                 300                 


Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln 
305                 310                 315                 320 


Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser 
                325                 330                 335     


Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser 
            340                 345                 350         


Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu 
        355                 360                 365             


Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro 
    370                 375                 380                 


Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala 
385                 390                 395                 400 


Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu 
                405                 410                 415     


Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser 
            420                 425                 430         


Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys 
        435                 440                 445             


Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val 
    450                 455                 460                 


Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu 
465                 470                 475                 480 


Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala 
                485                 490                 495     


Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu 
            500                 505                 510         


Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser Gly 
        515                 520                 525             


Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met Cys 
    530                 535                 540                 


Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln Thr Leu Lys Arg 
545                 550                 555                 560 


Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp Arg Leu Glu Ala 
                565                 570                 575     


Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser Leu Pro Leu Tyr 
            580                 585                 590         


Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp Arg Asp Ala Phe 
        595                 600                 605             


Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys Asp Leu 
    610                 615                 620         


<210>  26
<211>  3417
<212>  DNA
<213>  artificial

<220>
<223>  synthesized foamy virus Pol gene

<400>  26
atgaatcccc tccaactgtt gcagcctctg cccgcagaga tcaaagggac taaactgctg       60

gctcattggg actctggagc aaccataaca tgcataccag aaagcttcct tgaggacgag      120

cagcctatca aaaaaacatt gattaagacg atccacgggg aaaagcagca gaacgtgtat      180

tacgttacct ttaaggtgaa gggccggaaa gtcgaggccg aggtcattgc ctctccatac      240

gaatacattc tgctctcacc caccgacgtg ccatggttga cccagcagcc tcttcagctg      300

actatcctgg tccctttgca ggagtaccag gaaaagattc tgagcaagac ggcgcttccc      360

gaagatcaga aacagcagct gaagaccctc ttcgtgaaat acgataatct ctggcagcac      420

tgggaaaacc aggtgggcca tcggaagatt cgaccccaca atatcgccac gggcgactat      480

ccacctaggc ctcagaagca gtatcccatc aacccaaaag caaaaccaag catccagatc      540

gtcatcgatg atttgcttaa gcaaggagtg ctcaccccac aaaatagcac tatgaacacc      600

ccagtgtacc ccgtgcccaa accggacggc agatggagaa tggtattgga ctatcgcgaa      660

gttaacaaaa ccataccttt gaccgcagcc cagaatcaac acagcgccgg catcttggct      720

acgatcgtga gacagaagta caaaacaact ctcgatctgg ccaacggctt ttgggctcac      780

ccaatcactc cagagagcta ctggcttacc gcctttacat ggcaggggaa acaatactgt      840

tggacccggc tgcctcaggg gttcttgaat tcacccgcac tgtttacagc tgacgtcgtt      900

gatctgctga aagaaatccc caatgtgcag gtatacgtgg acgacatcta tctttcccac      960

gacgatccaa aagagcatgt tcagcagctc gaaaaagttt tccagatcct gctgcaggct     1020

ggttatgtcg tctcactcaa gaagtctgag ataggacaaa agactgtgga gtttctggga     1080

tttaacatca ccaaggaagg acggggattg actgatacgt tcaagactaa gctgctcaac     1140

attactcctc ccaaggatct taagcagctg cagagtattc ttggcttgct caattttgcc     1200

cggaatttta tccctaactt cgctgagctt gttcagcccc tgtataatct gatagcctcc     1260

gccaagggta agtacatcga atggagcgag gagaatacta aacagttgaa catggtgatt     1320

gaggcactta acactgcctc caacttggag gaacgactgc cagagcagcg acttgtgatt     1380

aaagtgaaca cctcaccaag tgcggggtac gtgcgctact acaacgagac aggcaaaaag     1440

cccataatgt acctgaacta tgtcttctca aaagctgagc tcaagtttag catgctcgag     1500

aagctgctta ctaccatgca caaggccctg ataaaggcca tggaccttgc catggggcaa     1560

gaaatcctcg tgtacagccc catcgtttcc atgacgaaga tccagaaaac accactgccc     1620

gaacgaaagg ccttgcctat cagatggatt acttggatga cctaccttga ggacccccgc     1680

atccagtttc attatgataa gaccctgcct gaactgaaac acatcccaga cgtgtacacc     1740

tccagtcagt ccccagtcaa gcacccttct caatatgaag gagtgtttta taccgatggg     1800

agtgccatca aatcccctga ccccacaaaa agtaacaacg ccggtatggg tatcgtccac     1860

gcgacctata agcccgagta tcaggtactg aaccagtggt ccatcccgct ggggaatcat     1920

accgcccaga tggcggaaat tgccgcagtc gagtttgcct gcaaaaaggc attgaaaatc     1980

ccagggcctg tcctggtcat caccgactct ttctacgtag ccgagtcagc caataaggaa     2040

ctgccctatt ggaaaagtaa tggcttcgtg aacaacaaga agaagccact gaaacatatt     2100

agcaaatgga aatctattgc cgagtgtctg tctatgaagc ccgacatcac tatccagcac     2160

gaaaagggcc atcagcccac caacactagt atccatacgg agggaaacgc tctggccgat     2220

aagctagcca ctcaagggag ttacgtcgtg aactgcaaca ccaagaaacc taaccttgac     2280

gccgaattgg accaattgct gcagggacat tacataaagg gctaccccaa gcagtatacc     2340

tattttctgg aagacggcaa ggtaaaagtg tcccggccag agggcgtcaa gatcatcccg     2400

ccacaaagcg acagacagaa aatcgttctg caggcccaca acctcgctca tactgggcgc     2460

gaagctactc tgctcaagat tgccaatctg tattggtggc cgaatatgag aaaagacgtc     2520

gtaaagcaac tggggcgctg tcagcagtgt ttgatcacta acgcaagtaa caaagcaagt     2580

gggccgattc ttcgaccaga ccgccctcag aaaccgttcg ataagttttt tatagattac     2640

attggacctc tgcctcccag tcaaggctac ctctacgtgc tggtagtggt cgatggcatg     2700

acgggattca catggctgta cccgaccaag gcgccgagta cttccgcgac ggtcaagagc     2760

cttaacgttc tcacctccat agctatcccc aaagttatcc actccgacca gggcgcagct     2820

ttcaccagct ctaccttcgc ggagtgggcc aaagagaggg ggattcactt ggaattctca     2880

acgccttacc acccccaatc tagcggaaag gtcgagagaa aaaattcaga tatcaaaaga     2940

ctgttgacca agctgcttgt tggccgccct acaaagtggt atgacctcct gcctgtcgtc     3000

cagctggcac tgaacaacac ctacagcccc gtgctcaagt atacacctca tcagttgctg     3060

tttggtattg atagtaacac tcctttcgca aatcaggata cgttggatct cactcgcgaa     3120

gaagagctca gtttgctgca ggagatacgc acgagtctgt accacccttc cactcctccc     3180

acttctagta ggtcttggtc tccagttgtg ggacagcttg ttcaggaaag agtcgcccgg     3240

cccgcatcac tgcggccccg gtggcacaaa ccgtctactg tactgaaggt gctcaaccca     3300

cggacggtgg taatccttga ccatctcgga aacaaccgga cagtgtcaat cgataacctc     3360

aagccaacct cccaccaaaa cggcacaacc aatgacacag ccacaatgga tcattag        3417


<210>  27
<211>  1138
<212>  PRT
<213>  artificial

<220>
<223>  synthesized foamy virus Pol protein

<400>  27

Met Asn Pro Leu Gln Leu Leu Gln Pro Leu Pro Ala Glu Ile Lys Gly 
1               5                   10                  15      


Thr Lys Leu Leu Ala His Trp Asp Ser Gly Ala Thr Ile Thr Cys Ile 
            20                  25                  30          


Pro Glu Ser Phe Leu Glu Asp Glu Gln Pro Ile Lys Lys Thr Leu Ile 
        35                  40                  45              


Lys Thr Ile His Gly Glu Lys Gln Gln Asn Val Tyr Tyr Val Thr Phe 
    50                  55                  60                  


Lys Val Lys Gly Arg Lys Val Glu Ala Glu Val Ile Ala Ser Pro Tyr 
65                  70                  75                  80  


Glu Tyr Ile Leu Leu Ser Pro Thr Asp Val Pro Trp Leu Thr Gln Gln 
                85                  90                  95      


Pro Leu Gln Leu Thr Ile Leu Val Pro Leu Gln Glu Tyr Gln Glu Lys 
            100                 105                 110         


Ile Leu Ser Lys Thr Ala Leu Pro Glu Asp Gln Lys Gln Gln Leu Lys 
        115                 120                 125             


Thr Leu Phe Val Lys Tyr Asp Asn Leu Trp Gln His Trp Glu Asn Gln 
    130                 135                 140                 


Val Gly His Arg Lys Ile Arg Pro His Asn Ile Ala Thr Gly Asp Tyr 
145                 150                 155                 160 


Pro Pro Arg Pro Gln Lys Gln Tyr Pro Ile Asn Pro Lys Ala Lys Pro 
                165                 170                 175     


Ser Ile Gln Ile Val Ile Asp Asp Leu Leu Lys Gln Gly Val Leu Thr 
            180                 185                 190         


Pro Gln Asn Ser Thr Met Asn Thr Pro Val Tyr Pro Val Pro Lys Pro 
        195                 200                 205             


Asp Gly Arg Trp Arg Met Val Leu Asp Tyr Arg Glu Val Asn Lys Thr 
    210                 215                 220                 


Ile Pro Leu Thr Ala Ala Gln Asn Gln His Ser Ala Gly Ile Leu Ala 
225                 230                 235                 240 


Thr Ile Val Arg Gln Lys Tyr Lys Thr Thr Leu Asp Leu Ala Asn Gly 
                245                 250                 255     


Phe Trp Ala His Pro Ile Thr Pro Glu Ser Tyr Trp Leu Thr Ala Phe 
            260                 265                 270         


Thr Trp Gln Gly Lys Gln Tyr Cys Trp Thr Arg Leu Pro Gln Gly Phe 
        275                 280                 285             


Leu Asn Ser Pro Ala Leu Phe Thr Ala Asp Val Val Asp Leu Leu Lys 
    290                 295                 300                 


Glu Ile Pro Asn Val Gln Val Tyr Val Asp Asp Ile Tyr Leu Ser His 
305                 310                 315                 320 


Asp Asp Pro Lys Glu His Val Gln Gln Leu Glu Lys Val Phe Gln Ile 
                325                 330                 335     


Leu Leu Gln Ala Gly Tyr Val Val Ser Leu Lys Lys Ser Glu Ile Gly 
            340                 345                 350         


Gln Lys Thr Val Glu Phe Leu Gly Phe Asn Ile Thr Lys Glu Gly Arg 
        355                 360                 365             


Gly Leu Thr Asp Thr Phe Lys Thr Lys Leu Leu Asn Ile Thr Pro Pro 
    370                 375                 380                 


Lys Asp Leu Lys Gln Leu Gln Ser Ile Leu Gly Leu Leu Asn Phe Ala 
385                 390                 395                 400 


Arg Asn Phe Ile Pro Asn Phe Ala Glu Leu Val Gln Pro Leu Tyr Asn 
                405                 410                 415     


Leu Ile Ala Ser Ala Lys Gly Lys Tyr Ile Glu Trp Ser Glu Glu Asn 
            420                 425                 430         


Thr Lys Gln Leu Asn Met Val Ile Glu Ala Leu Asn Thr Ala Ser Asn 
        435                 440                 445             


Leu Glu Glu Arg Leu Pro Glu Gln Arg Leu Val Ile Lys Val Asn Thr 
    450                 455                 460                 


Ser Pro Ser Ala Gly Tyr Val Arg Tyr Tyr Asn Glu Thr Gly Lys Lys 
465                 470                 475                 480 


Pro Ile Met Tyr Leu Asn Tyr Val Phe Ser Lys Ala Glu Leu Lys Phe 
                485                 490                 495     


Ser Met Leu Glu Lys Leu Leu Thr Thr Met His Lys Ala Leu Ile Lys 
            500                 505                 510         


Ala Met Asp Leu Ala Met Gly Gln Glu Ile Leu Val Tyr Ser Pro Ile 
        515                 520                 525             


Val Ser Met Thr Lys Ile Gln Lys Thr Pro Leu Pro Glu Arg Lys Ala 
    530                 535                 540                 


Leu Pro Ile Arg Trp Ile Thr Trp Met Thr Tyr Leu Glu Asp Pro Arg 
545                 550                 555                 560 


Ile Gln Phe His Tyr Asp Lys Thr Leu Pro Glu Leu Lys His Ile Pro 
                565                 570                 575     


Asp Val Tyr Thr Ser Ser Gln Ser Pro Val Lys His Pro Ser Gln Tyr 
            580                 585                 590         


Glu Gly Val Phe Tyr Thr Asp Gly Ser Ala Ile Lys Ser Pro Asp Pro 
        595                 600                 605             


Thr Lys Ser Asn Asn Ala Gly Met Gly Ile Val His Ala Thr Tyr Lys 
    610                 615                 620                 


Pro Glu Tyr Gln Val Leu Asn Gln Trp Ser Ile Pro Leu Gly Asn His 
625                 630                 635                 640 


Thr Ala Gln Met Ala Glu Ile Ala Ala Val Glu Phe Ala Cys Lys Lys 
                645                 650                 655     


Ala Leu Lys Ile Pro Gly Pro Val Leu Val Ile Thr Asp Ser Phe Tyr 
            660                 665                 670         


Val Ala Glu Ser Ala Asn Lys Glu Leu Pro Tyr Trp Lys Ser Asn Gly 
        675                 680                 685             


Phe Val Asn Asn Lys Lys Lys Pro Leu Lys His Ile Ser Lys Trp Lys 
    690                 695                 700                 


Ser Ile Ala Glu Cys Leu Ser Met Lys Pro Asp Ile Thr Ile Gln His 
705                 710                 715                 720 


Glu Lys Gly His Gln Pro Thr Asn Thr Ser Ile His Thr Glu Gly Asn 
                725                 730                 735     


Ala Leu Ala Asp Lys Leu Ala Thr Gln Gly Ser Tyr Val Val Asn Cys 
            740                 745                 750         


Asn Thr Lys Lys Pro Asn Leu Asp Ala Glu Leu Asp Gln Leu Leu Gln 
        755                 760                 765             


Gly His Tyr Ile Lys Gly Tyr Pro Lys Gln Tyr Thr Tyr Phe Leu Glu 
    770                 775                 780                 


Asp Gly Lys Val Lys Val Ser Arg Pro Glu Gly Val Lys Ile Ile Pro 
785                 790                 795                 800 


Pro Gln Ser Asp Arg Gln Lys Ile Val Leu Gln Ala His Asn Leu Ala 
                805                 810                 815     


His Thr Gly Arg Glu Ala Thr Leu Leu Lys Ile Ala Asn Leu Tyr Trp 
            820                 825                 830         


Trp Pro Asn Met Arg Lys Asp Val Val Lys Gln Leu Gly Arg Cys Gln 
        835                 840                 845             


Gln Cys Leu Ile Thr Asn Ala Ser Asn Lys Ala Ser Gly Pro Ile Leu 
    850                 855                 860                 


Arg Pro Asp Arg Pro Gln Lys Pro Phe Asp Lys Phe Phe Ile Asp Tyr 
865                 870                 875                 880 


Ile Gly Pro Leu Pro Pro Ser Gln Gly Tyr Leu Tyr Val Leu Val Val 
                885                 890                 895     


Val Asp Gly Met Thr Gly Phe Thr Trp Leu Tyr Pro Thr Lys Ala Pro 
            900                 905                 910         


Ser Thr Ser Ala Thr Val Lys Ser Leu Asn Val Leu Thr Ser Ile Ala 
        915                 920                 925             


Ile Pro Lys Val Ile His Ser Asp Gln Gly Ala Ala Phe Thr Ser Ser 
    930                 935                 940                 


Thr Phe Ala Glu Trp Ala Lys Glu Arg Gly Ile His Leu Glu Phe Ser 
945                 950                 955                 960 


Thr Pro Tyr His Pro Gln Ser Ser Gly Lys Val Glu Arg Lys Asn Ser 
                965                 970                 975     


Asp Ile Lys Arg Leu Leu Thr Lys Leu Leu Val Gly Arg Pro Thr Lys 
            980                 985                 990         


Trp Tyr Asp Leu Leu Pro Val Val  Gln Leu Ala Leu Asn  Asn Thr Tyr 
        995                 1000                 1005             


Ser Pro  Val Leu Lys Tyr Thr  Pro His Gln Leu Leu  Phe Gly Ile 
    1010                 1015                 1020             


Asp Ser  Asn Thr Pro Phe Ala  Asn Gln Asp Thr Leu  Asp Leu Thr 
    1025                 1030                 1035             


Arg Glu  Glu Glu Leu Ser Leu  Leu Gln Glu Ile Arg  Thr Ser Leu 
    1040                 1045                 1050             


Tyr His  Pro Ser Thr Pro Pro  Thr Ser Ser Arg Ser  Trp Ser Pro 
    1055                 1060                 1065             


Val Val  Gly Gln Leu Val Gln  Glu Arg Val Ala Arg  Pro Ala Ser 
    1070                 1075                 1080             


Leu Arg  Pro Arg Trp His Lys  Pro Ser Thr Val Leu  Lys Val Leu 
    1085                 1090                 1095             


Asn Pro  Arg Thr Val Val Ile  Leu Asp His Leu Gly  Asn Asn Arg 
    1100                 1105                 1110             


Thr Val  Ser Ile Asp Asn Leu  Lys Pro Thr Ser His  Gln Asn Gly 
    1115                 1120                 1125             


Thr Thr  Asn Asp Thr Ala Thr  Met Asp His 
    1130                 1135             


<210>  28
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  28
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcggggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca g                                     511


<210>  29
<211>  8509
<212>  DNA
<213>  artificial

<220>
<223>  synthetic foamy virus vector containing PGK promoter associated 
       with gammaC gene

<400>  29
tcgcgcgttc tcgaggagct tggcccattg catacgttgt atccatatca taatatgtac       60

atttatattg gctcatgtcc aacattaccg ccatgttgac attgattatt gactagttat      120

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca      180

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca      240

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg      300

gagtatttac gctaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg      360

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc      420

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg      480

atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca      540

agtctccacc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      600

cagagcttct agattgtacg ggagctctct cttcactact cgctgcgtcg agagtgtacg      660

agactctcca ggtttggtaa gaaatatttt atattgttat aatgttacta tgatccatta      720

acactctgct tatagattgt aagggtgatt gcaatgcttt ctgcataaaa ctttggtttt      780

cttgttaatc aataaaccga cttgattcga gaacctactc atatattatt gtctctttta      840

tactttatta agtaaaagga tttgtatatt agccttgcta agggagacat ctagtgatat      900

aagtgtgaac tacacttatc ttaaatgatg taactcctta ggataatcaa tatacaaaat      960

tccatgacaa ttggcgccca acgtggggct cgaatataag tcgggtttat ttgtaaatta     1020

tccctaggga cctccgagca tagcgggagg catataaaag ccaatagaca atggctagca     1080

ggaagtaatg ttgaagaata tgaacttgat gttgaagctc tggttgtaat tttaagagat     1140

agaaatatac caagaaatcc tttacatgga gaagttatag gtcttcgcct tactgaagga     1200

tggtggggac aaattgagag atttcagatg gtacgttgat tcgaattaag gctatggatt     1260

tggccatggg acaagaaata ttagtttata gtcccattgt atctatgact aaaatacaaa     1320

aaactccact accagaaaga aaagctttac ccattagatg gataacatgg atgacttatt     1380

tagaagatcc aagaatccaa tttcattatg ataaaacctt accagaactt aagcatattc     1440

cagatgtata tacatctagt cagtctcctg ttaaacatcc ttctcaatat gaaggagtgt     1500

tttatactga tggctcggcc atcaaaagtc ctgatcctac aaaaagcaat aatgctggca     1560

tgggaatagt acatgccaca tacaaacctg aatatcaagt tttgaatcaa tggtcaatac     1620

cactaggtaa tcatactgct cagatggctg aaatagctgc agttgaattt gcctgtaaaa     1680

aagctttaaa aatacctggt cctgtattag ttataactga tagtttctat gtagcagaaa     1740

gtgctaataa agaattacca tactggaaat ctaatgggtt tgttaataat aagaaaaagc     1800

ctcttaaaca tatctccaaa tggaaatcta ttgctgagtg tttatctatg aaaccagaca     1860

ttactattca acatgaaaaa ggcatcagcc tacaaatacc agtattcata ctgaaaggca     1920

atgccctagc agataagctt gccacccaag gaagttatgt ggttaattgt aataccaaaa     1980

aaccaaacct ggatgcagag ttggatcaat tattacaggg tcattatata aaaggatatc     2040

ccaaacaata tacatatttt ttagaagatg gcaaagtaaa agtttccaga cctgaagggg     2100

ttaaaattat tccccctcag tcagacagac aaaaaattgt gcttcaagcc cacaatttgg     2160

ctcacaccgg acgtgaagcc actcttttaa aaattgccaa cctttattgg tggccaaata     2220

tgagaaagga tgtggttaaa caactaggac gctgtcaaca gtgtttaatc acaaatgctt     2280

ccaacaaagc ctctggtcct attctaagac cagataggcc tcaaaaacct tttgataaat     2340

tctttattga ctatattgga cctttgccac cttcacaggg atacctatat gtattagtag     2400

ttgttgatgg aatgacagga ttcacttggt tataccccac taaggctcct tctactagcg     2460

caactgttaa atctctcaat gtactcacta gtattgcaat tccaaaggtg attcactctg     2520

atcaaggtgc agcattcact tcttcaacct ttgctgaatg ggcaaaggaa agaggtatac     2580

atttggaatt cagtactcct tatcaccccc aaagtggtag taaggtggaa aggaaaaata     2640

gtgatataaa acgactttta actaaactgc tagtaggaag acccacaaag tggtatgacc     2700

tattgcctgt tgtacaactt gctttaaaca acacctatag ccctgtatta aaatatactc     2760

cacatcaact cttatttggt atagattcaa atactccatt tgcaaatcaa gatacacttg     2820

acttgaccag agaagaagaa ctttctcttt tacaggaaat tcgtacttct ttataccatc     2880

catccacccc tccagcctcc tctcgttcct ggtctcctgt tgttggccaa ttggtccagg     2940

agagggtggc taggcctgct tctttgagac ctcgttggca taaaccgtct actgtactta     3000

aggtgttgaa tccaaggact gttgttattt tggaccatct tggcaacaac agaactgtaa     3060

gtatagataa tttaaaacct acttctcatc agaatggcac caccaatgac actgcaacaa     3120

tggatcattt ggaaaaaaat gaataaagcg catgaggcac ttcaaaatac aacaactgtg     3180

actgaacagc agaaggaaca aattatactg gacattcaaa atgaagaagt acaaccaact     3240

aggagagata aatttagata tctgctttat acttgttgtg ctactagctc aagagtattg     3300

gcctggatgt ttttagtttg tatattgtta atcattgttt tggtttcatg ctttgtgact     3360

atatccagaa tacaatggaa taaggatatt caggtattag gacctgtaat agactggaat     3420

gttactcaaa gagctgttta tcaaccctta cagactagaa ggattgcacg ttcccttaga     3480

atgcagcatc ctgttccaaa atatgtggag gtaaatatga ctagtattcc acaaggtgta     3540

tactatgaac cccatccggc gcgccagatc tgcatgccca cggggttggg gttgcgcctt     3600

ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg ttccgggaaa     3660

cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag cgtcacccgg     3720

atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc cctaagtcgg     3780

gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc acgtctcact     3840

agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc gcgatgggct     3900

gtggccaata gcggctgctc agcggggcgc gccgagagca gcggccggga aggggcggtg     3960

cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg gtgttccgca     4020

ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg aatcaccgac     4080

ctctctcccc agggggatcc accggtcgcc gccaccatgc tgaaaccaag cctgcccttt     4140

acaagcctgc tgttcctgca gctgccactg ctgggggtcg gactgaatac tacaatcctg     4200

acaccaaacg gaaatgagga caccacagcc gatttctttc tgactaccat gcccactgac     4260

agtctgtcag tgagcaccct gccactgccc gaggtccagt gcttcgtgtt taacgtcgaa     4320

tatatgaact gtacctggaa tagctcctct gaacctcagc caacaaatct gactctgcac     4380

tactggtata agaactctga caatgataag gtgcagaaat gctcacatta tctgttcagc     4440

gaggaaatca cctccggctg tcagctgcag aagaaagaga ttcacctgta ccagacattt     4500

gtggtccagc tgcaggatcc ccgggaacct cggagacagg ccactcagat gctgaagctg     4560

cagaacctgg tcatcccatg ggctcccgag aatctgaccc tgcataaact gtccgagtct     4620

cagctggaac tgaactggaa caataggttc ctgaatcact gcctggagca tctggtgcag     4680

taccgcacag actgggatca ctcttggact gaacagagtg tggactatcg acataagttt     4740

agtctgcctt cagtggatgg gcagaaaagg tacacattca gggtccgctc tcggttcaac     4800

ccactgtgcg gaagcgccca gcactggagc gagtggtccc accccatcca ttgggggtct     4860

aacaccagca aggagaatcc tttcctgttt gccctggaag ctgtggtcat ttcagtggga     4920

agcatgggcc tgatcattag cctgctgtgc gtgtacttct ggctggagcg gaccatgcct     4980

agaatcccaa cactgaagaa cctggaggac ctggtgacag aatatcacgg caatttttcc     5040

gcttggtctg gggtcagtaa aggactggca gagagcctgc agcccgatta ctccgagcgg     5100

ctgtgcctgg tgtccgaaat tccccctaaa ggcggggcac tgggagaagg ccctggggcc     5160

tccccctgca accagcactc accctattgg gcaccaccct gttacaccct gaaacccgaa     5220

acttaagcgg ccgtcgaggg ctgcaggaat tcgagcatct taccgccatt tattcccata     5280

tttgttctgt ttttcttgat ttgggtatac atttaaatgt taataaaaca aaatggtggg     5340

gcaatcattt acatttttag ggatatgtaa ttactagttc aggtgtattg ccacaagaca     5400

aacatgttaa gaaactttcc cgttatttac gctctgttcc tgttaatcaa cctctggatt     5460

acaaaatttg tgaaagattg actgatattc ttaactatgt tgctcctttt acgctgtgtg     5520

gatatgctgc tttatagcct ctgtatctag ctattgcttc ccgtacggct ttcgttttct     5580

cctccttgta taaatcctgg ttgctgtctc ttttagagga gttgtggccc gttgtccgtc     5640

aacgtggcgt ggtgtgctct gtgtttgctg acgcaacccc cactggctgg ggcattgcca     5700

ccacctgtca actcctttct gggactttcg ctttccccct cccgatcgcc acggcagaac     5760

tcatcgccgc ctgccttgcc cgctgctgga caggggctag gttgctgggc actgataatt     5820

ccgtggtgtt gtcggggaag ctgacgtcct ttcgaattcg atatcaagct tatcgatacc     5880

gtcgacggtt accaagcagc tatggaagct tatggacctc agagaggaag taacgaggag     5940

agggtgtggt ggaatgccac tagaaaccag ggaaaacaag gaggagagta ttacagggaa     6000

ggaggtgaag aacctcatta cccaaatact cctgctcctc atagacgtac ctgggatgag     6060

agacacaagg ttcttaaatt gtcctcattc gctactccct ctgacatcca acgctgggct     6120

actaactcta gattgtacgg gagctctctt cactactcgc tgcgtcgaga gtgtacgaga     6180

ctctccaggt ttggtaagaa atattttata ttgttataat gttactatga tccattaaca     6240

ctctgcttat agattgtaag ggtgattgca atgctttctg cataaaactt tggttttctt     6300

gttaatcaat aaaccgactt gattcgagaa cctactcata tattattgtc tcttttatac     6360

tttattaagt aaaaggattt gtatattagc cttgctaagg gagacatcta gtgatataag     6420

tgtgaactac acttatctta aatgatgtaa ctccttagga taatcaatat acaaaattcc     6480

atgacaattg gcgataccca gctgcgctct tccgcttcct cgctcactga ctcgctgcgc     6540

tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc     6600

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg     6660

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     6720

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     6780

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     6840

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     6900

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     6960

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     7020

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     7080

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     7140

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     7200

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     7260

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     7320

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     7380

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     7440

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     7500

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     7560

tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca     7620

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     7680

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     7740

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     7800

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     7860

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     7920

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     7980

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     8040

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     8100

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     8160

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     8220

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     8280

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     8340

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     8400

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt     8460

atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtc                 8509


<210>  30
<211>  9284
<212>  DNA
<213>  artificial

<220>
<223>  synthetic foamy virus vector containing PGK promoter associated 
       with GFP-2A-gammaC

<400>  30
tcgcgcgttc tcgaggagct tggcccattg catacgttgt atccatatca taatatgtac       60

atttatattg gctcatgtcc aacattaccg ccatgttgac attgattatt gactagttat      120

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca      180

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca      240

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg      300

gagtatttac gctaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg      360

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc      420

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg      480

atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca      540

agtctccacc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      600

cagagcttct agattgtacg ggagctctct cttcactact cgctgcgtcg agagtgtacg      660

agactctcca ggtttggtaa gaaatatttt atattgttat aatgttacta tgatccatta      720

acactctgct tatagattgt aagggtgatt gcaatgcttt ctgcataaaa ctttggtttt      780

cttgttaatc aataaaccga cttgattcga gaacctactc atatattatt gtctctttta      840

tactttatta agtaaaagga tttgtatatt agccttgcta agggagacat ctagtgatat      900

aagtgtgaac tacacttatc ttaaatgatg taactcctta ggataatcaa tatacaaaat      960

tccatgacaa ttggcgccca acgtggggct cgaatataag tcgggtttat ttgtaaatta     1020

tccctaggga cctccgagca tagcgggagg catataaaag ccaatagaca atggctagca     1080

ggaagtaatg ttgaagaata tgaacttgat gttgaagctc tggttgtaat tttaagagat     1140

agaaatatac caagaaatcc tttacatgga gaagttatag gtcttcgcct tactgaagga     1200

tggtggggac aaattgagag atttcagatg gtacgttgat tcgaattaag gctatggatt     1260

tggccatggg acaagaaata ttagtttata gtcccattgt atctatgact aaaatacaaa     1320

aaactccact accagaaaga aaagctttac ccattagatg gataacatgg atgacttatt     1380

tagaagatcc aagaatccaa tttcattatg ataaaacctt accagaactt aagcatattc     1440

cagatgtata tacatctagt cagtctcctg ttaaacatcc ttctcaatat gaaggagtgt     1500

tttatactga tggctcggcc atcaaaagtc ctgatcctac aaaaagcaat aatgctggca     1560

tgggaatagt acatgccaca tacaaacctg aatatcaagt tttgaatcaa tggtcaatac     1620

cactaggtaa tcatactgct cagatggctg aaatagctgc agttgaattt gcctgtaaaa     1680

aagctttaaa aatacctggt cctgtattag ttataactga tagtttctat gtagcagaaa     1740

gtgctaataa agaattacca tactggaaat ctaatgggtt tgttaataat aagaaaaagc     1800

ctcttaaaca tatctccaaa tggaaatcta ttgctgagtg tttatctatg aaaccagaca     1860

ttactattca acatgaaaaa ggcatcagcc tacaaatacc agtattcata ctgaaaggca     1920

atgccctagc agataagctt gccacccaag gaagttatgt ggttaattgt aataccaaaa     1980

aaccaaacct ggatgcagag ttggatcaat tattacaggg tcattatata aaaggatatc     2040

ccaaacaata tacatatttt ttagaagatg gcaaagtaaa agtttccaga cctgaagggg     2100

ttaaaattat tccccctcag tcagacagac aaaaaattgt gcttcaagcc cacaatttgg     2160

ctcacaccgg acgtgaagcc actcttttaa aaattgccaa cctttattgg tggccaaata     2220

tgagaaagga tgtggttaaa caactaggac gctgtcaaca gtgtttaatc acaaatgctt     2280

ccaacaaagc ctctggtcct attctaagac cagataggcc tcaaaaacct tttgataaat     2340

tctttattga ctatattgga cctttgccac cttcacaggg atacctatat gtattagtag     2400

ttgttgatgg aatgacagga ttcacttggt tataccccac taaggctcct tctactagcg     2460

caactgttaa atctctcaat gtactcacta gtattgcaat tccaaaggtg attcactctg     2520

atcaaggtgc agcattcact tcttcaacct ttgctgaatg ggcaaaggaa agaggtatac     2580

atttggaatt cagtactcct tatcaccccc aaagtggtag taaggtggaa aggaaaaata     2640

gtgatataaa acgactttta actaaactgc tagtaggaag acccacaaag tggtatgacc     2700

tattgcctgt tgtacaactt gctttaaaca acacctatag ccctgtatta aaatatactc     2760

cacatcaact cttatttggt atagattcaa atactccatt tgcaaatcaa gatacacttg     2820

acttgaccag agaagaagaa ctttctcttt tacaggaaat tcgtacttct ttataccatc     2880

catccacccc tccagcctcc tctcgttcct ggtctcctgt tgttggccaa ttggtccagg     2940

agagggtggc taggcctgct tctttgagac ctcgttggca taaaccgtct actgtactta     3000

aggtgttgaa tccaaggact gttgttattt tggaccatct tggcaacaac agaactgtaa     3060

gtatagataa tttaaaacct acttctcatc agaatggcac caccaatgac actgcaacaa     3120

tggatcattt ggaaaaaaat gaataaagcg catgaggcac ttcaaaatac aacaactgtg     3180

actgaacagc agaaggaaca aattatactg gacattcaaa atgaagaagt acaaccaact     3240

aggagagata aatttagata tctgctttat acttgttgtg ctactagctc aagagtattg     3300

gcctggatgt ttttagtttg tatattgtta atcattgttt tggtttcatg ctttgtgact     3360

atatccagaa tacaatggaa taaggatatt caggtattag gacctgtaat agactggaat     3420

gttactcaaa gagctgttta tcaaccctta cagactagaa ggattgcacg ttcccttaga     3480

atgcagcatc ctgttccaaa atatgtggag gtaaatatga ctagtattcc acaaggtgta     3540

tactatgaac cccatccggc gcgccagatc tgcatgccac ggggttgggg ttgcgccttt     3600

tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt tccgggaaac     3660

gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga     3720

tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg     3780

aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta     3840

gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg cgatgggctg     3900

tggccaatag cggctgctca gcggggcgcg ccgagagcag cggccgggaa ggggcggtgc     3960

gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat     4020

tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga atcaccgacc     4080

tctctcccca gggggatcca ccggtcgccg ccaccatggt gagcaagggc gaggagctgt     4140

tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca     4200

gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct     4260

gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg     4320

tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca     4380

tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga     4440

cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca     4500

tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac tacaacagcc     4560

acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac ttcaagatcc     4620

gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca     4680

tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag tccgccctga     4740

gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg     4800

ggatcactct cggcatggac gagctgtaca agggtgaggg cagaggaagt cttctaacat     4860

gcggtgacgt ggaggagaat ccgggcccta tgctgaaacc aagcctgccc tttacaagcc     4920

tgctgttcct gcagctgcca ctgctggggg tcggactgaa tactacaatc ctgacaccaa     4980

acggaaatga ggacaccaca gccgatttct ttctgactac catgcccact gacagtctgt     5040

cagtgagcac cctgccactg cccgaggtcc agtgcttcgt gtttaacgtc gaatatatga     5100

actgtacctg gaatagctcc tctgaacctc agccaacaaa tctgactctg cactactggt     5160

ataagaactc tgacaatgat aaggtgcaga aatgctcaca ttatctgttc agcgaggaaa     5220

tcacctccgg ctgtcagctg cagaagaaag agattcacct gtaccagaca tttgtggtcc     5280

agctgcagga tccccgggaa cctcggagac aggccactca gatgctgaag ctgcagaacc     5340

tggtcatccc atgggctccc gagaatctga ccctgcataa actgtccgag tctcagctgg     5400

aactgaactg gaacaatagg ttcctgaatc actgcctgga gcatctggtg cagtaccgca     5460

cagactggga tcactcttgg actgaacaga gtgtggacta tcgacataag tttagtctgc     5520

cttcagtgga tgggcagaaa aggtacacat tcagggtccg ctctcggttc aacccactgt     5580

gcggaagcgc ccagcactgg agcgagtggt cccaccccat ccattggggg tctaacacca     5640

gcaaggagaa tcctttcctg tttgccctgg aagctgtggt catttcagtg ggaagcatgg     5700

gcctgatcat tagcctgctg tgcgtgtact tctggctgga gcggaccatg cctagaatcc     5760

caacactgaa gaacctggag gacctggtga cagaatatca cggcaatttt tccgcttggt     5820

ctggggtcag taaaggactg gcagagagcc tgcagcccga ttactccgag cggctgtgcc     5880

tggtgtccga aattccccct aaaggcgggg cactgggaga aggccctggg gcctccccct     5940

gcaaccagca ctcaccctat tgggcaccac cctgttacac cctgaaaccc gaaacttaag     6000

cggccgcgtc gagggctgca ggaattcgag catcttaccg ccatttattc ccatatttgt     6060

tctgtttttc ttgatttggg tatacattta aatgttaata aaacaaaatg gtggggcaat     6120

catttacatt tttagggata tgtaattact agttcaggtg tattgccaca agacaaacat     6180

gttaagaaac tttcccgtta tttacgctct gttcctgtta atcaacctct ggattacaaa     6240

atttgtgaaa gattgactga tattcttaac tatgttgctc cttttacgct gtgtggatat     6300

gctgctttat agcctctgta tctagctatt gcttcccgta cggctttcgt tttctcctcc     6360

ttgtataaat cctggttgct gtctctttta gaggagttgt ggcccgttgt ccgtcaacgt     6420

ggcgtggtgt gctctgtgtt tgctgacgca acccccactg gctggggcat tgccaccacc     6480

tgtcaactcc tttctgggac tttcgctttc cccctcccga tcgccacggc agaactcatc     6540

gccgcctgcc ttgcccgctg ctggacaggg gctaggttgc tgggcactga taattccgtg     6600

gtgttgtcgg ggaagctgac gtcctttcga attcgatatc aagcttatcg ataccgtcga     6660

cggttaccaa gcagctatgg aagcttatgg acctcagaga ggaagtaacg aggagagggt     6720

gtggtggaat gccactagaa accagggaaa acaaggagga gagtattaca gggaaggagg     6780

tgaagaacct cattacccaa atactcctgc tcctcataga cgtacctggg atgagagaca     6840

caaggttctt aaattgtcct cattcgctac tccctctgac atccaacgct gggctactaa     6900

ctctagattg tacgggagct ctcttcacta ctcgctgcgt cgagagtgta cgagactctc     6960

caggtttggt aagaaatatt ttatattgtt ataatgttac tatgatccat taacactctg     7020

cttatagatt gtaagggtga ttgcaatgct ttctgcataa aactttggtt ttcttgttaa     7080

tcaataaacc gacttgattc gagaacctac tcatatatta ttgtctcttt tatactttat     7140

taagtaaaag gatttgtata ttagccttgc taagggagac atctagtgat ataagtgtga     7200

actacactta tcttaaatga tgtaactcct taggataatc aatatacaaa attccatgac     7260

aattggcgat acccagctgc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     7320

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     7380

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     7440

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     7500

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     7560

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     7620

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     7680

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     7740

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     7800

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     7860

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     7920

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     7980

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     8040

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     8100

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     8160

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     8220

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     8280

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     8340

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     8400

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     8460

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     8520

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     8580

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     8640

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     8700

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     8760

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     8820

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     8880

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     8940

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     9000

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     9060

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     9120

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     9180

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     9240

gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtc                      9284


<210>  31
<211>  11529
<212>  DNA
<213>  artificial

<220>
<223>  lentiviral vector containing PGK promoter associated with FancA 
       gene

<400>  31
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggtatc ggttaacttt     4020

taaaagaaaa ggggggattg gggggtacag tgcaggggaa agaatagtag acataatagc     4080

aacagacata caaactaaag aattacaaaa acaaattaca aaaattcaaa attttccgat     4140

cacgagacta gcctcgagaa gcttgatatc gaattcccac ggggttgggg ttgcgccttt     4200

tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt tccgggaaac     4260

gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga     4320

tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg     4380

aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta     4440

gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg cgatgggctg     4500

tggccaatag cggctgctca gcggggcgcg ccgagagcag cggccgggaa ggggcggtgc     4560

gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat     4620

tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga atcaccgacc     4680

tctctcccca gggggatcca ccggtccgcc aaggccatgt ccgactcgtg ggtcccgaac     4740

tccgcctcgg gccaggaccc agggggccgc cggagggcct gggccgagct gctggcggga     4800

agggtcaaga gggaaaaata taatcctgaa agggcacaga aattaaagga atcagctgtg     4860

cgcctcctgc gaagccatca ggacctgaat gcccttttgc ttgaggtaga aggtccactg     4920

tgtaaaaaat tgtctctcag caaagtgatt gactgtgaca gttctgaggc ctatgctaat     4980

cattctagtt catttatagg ctctgctttg caggatcaag cctcaaggct gggggttccc     5040

gtgggtattc tctcagccgg gatggttgcc tctagcgtgg gacagatctg cacggctcca     5100

gcggagacca gtcaccctgt gctgctgact gtggagcaga gaaagaagct gtcttccctg     5160

ttagagtttg ctcagtattt attggcacac agtatgttct cccgtctttc cttctgtcaa     5220

gaattatgga aaatacagag ttctttgttg cttgaagcgg tgtggcatct tcacgtacaa     5280

ggcattgtga gcctgcaaga gctgctggaa agccatcccg acatgcatgc tgtgggatcg     5340

tggctcttca ggaatctgtg ctgcctttgt gaacagatgg aagcatcctg ccagcatgct     5400

gacgtcgcca gggccatgct ttctgatttt gttcaaatgt ttgttttgag gggatttcag     5460

aaaaactcag atctgagaag aactgtggag cctgaaaaaa tgccgcaggt cacggttgat     5520

gtactgcaga gaatgctgat ttttgcactt gacgctttgg ctgctggagt acaggaggag     5580

tcctccactc acaagatcgt gaggtgctgg ttcggagtgt tcagtggaca cacgcttggc     5640

agtgtaattt ccacagatcc tctgaagagg ttcttcagtc ataccctgac tcagatactc     5700

actcacagcc ctgtgctgaa agcatctgat gctgttcaga tgcagagaga gtggagcttt     5760

gcgcggacac accctctgct cacctcactg taccgcaggc tctttgtgat gctgagtgca     5820

gaggagttgg ttggccattt gcaagaagtt ctggaaacgc aggaggttca ctggcagaga     5880

gtgctctcct ttgtgtctgc cctggttgtc tgctttccag aagcgcagca gctgcttgaa     5940

gactgggtgg cgcgtttgat ggcccaggca ttcgagagct gccagctgga cagcatggtc     6000

actgcgttcc tggttgtgcg ccaggcagca ctggagggcc cctctgcgtt cctgtcatat     6060

gcagactggt tcaaggcctc ctttgggagc acacgaggct accatggctg cagcaagaag     6120

gccctggtct tcctgtttac gttcttgtca gaactcgtgc cttttgagtc tccccggtac     6180

ctgcaggtgc acattctcca cccacccctg gttcccagca agtaccgctc cctcctcaca     6240

gactacatct cattggccaa gacacggctg gccgacctca aggtttctat agaaaacatg     6300

ggactctacg aggatttgtc atcagctggg gacattactg agccccacag ccaagctctt     6360

caggatgttg aaaaggccat catggtgttt gagcatacgg ggaacatccc agtcaccgtc     6420

atggaggcca gcatattcag gaggccttac tacgtgtccc acttcctccc cgccctgctc     6480

acacctcgag tgctccccaa agtccctgac tcccgtgtgg cgtttataga gtctctgaag     6540

agagcagata aaatcccccc atctctgtac tccacctact gccaggcctg ctctgctgct     6600

gaagagaagc cagaagatgc agccctggga gtgagggcag aacccaactc tgctgaggag     6660

cccctgggac agctcacagc tgcactggga gagctgagag cctccatgac agaccccagc     6720

cagcgtgatg ttatatcggc acaggtggca gtgatttctg aaagactgag ggctgtcctg     6780

ggccacaatg aggatgacag cagcgttgag atatcaaaga ttcagctcag catcaacacg     6840

ccgagactgg agccacggga acacattgct gtggacctcc tgctgacgtc tttctgtcag     6900

aacctgatgg ctgcctccag tgtcgctccc ccggagaggc agggtccctg ggctgccctc     6960

ttcgtgagga ccatgtgtgg acgtgtgctc cctgcagtgc tcacccggct ctgccagctg     7020

ctccgtcacc agggcccgag cctgagtgcc ccacatgtgc tggggttggc tgccctggcc     7080

gtgcacctgg gtgagtccag gtctgcgctc ccagaggtgg atgtgggtcc tcctgcacct     7140

ggtgctggcc ttcctgtccc tgcgctcttt gacagcctcc tgacctgtag gacgagggat     7200

tccttgttct tctgcctgaa attttgtaca gcagcaattt cttactctct ctgcaagttt     7260

tcttcccagt cacgagatac tttgtgcagc tgcttatctc caggccttat taaaaagttt     7320

cagttcctca tgttcagatt gttctcagag gcccgacagc ctctttctga ggaggacgta     7380

gccagccttt cctggagacc cttgcacctt ccttctgcag actggcagag agctgccctc     7440

tctctctgga cacacagaac cttccgagag gtgttgaaag aggaagatgt tcacttaact     7500

taccaagact ggttacacct ggagctggaa attcaacctg aagctgatgc tctttcagat     7560

actgaacggc aggacttcca ccagtgggcg atccatgagc actttctccc tgagtcctcg     7620

gcttcagggg gctgtgacgg agacctgcag gctgcgtgta ccattcttgt caacgcactg     7680

atggatttcc accaaagctc aaggagttat gaccactcag aaaattctga tttggtcttt     7740

ggtggccgca caggaaatga ggatattatt tccagattgc aggagatggt agctgacctg     7800

gagctgcagc aagacctcat agtgcctctc ggccacaccc cttcccagga gcacttcctc     7860

tttgagattt tccgcagacg gctccaggct ctgacaagcg ggtggagcgt ggctgccagc     7920

cttcagagac agagggagct gctaatgtac aaacggatcc tcctccgcct gccttcgtct     7980

gtcctctgcg gcagcagctt ccaggcagaa cagcccatca ctgccagatg cgagcagttc     8040

ttccacttgg tcaactctga gatgagaaac ttctgctccc acggaggtgc cctgacacag     8100

gacatcactg cccacttctt caggggcctc ctgaacgcct gtctgcggag cagagacccc     8160

tccctgatgg tcgacttcat actggccaag tgccagacga aatgcccctt aattttgacc     8220

tctgctctgg tgtggtggcc gagcctggag cctgtgctgc tctgccggtg gaggagacac     8280

tgccagagcc cgctgccccg ggaactgcag aagctacaag aaggccggca gtttgccagc     8340

gatttcctct cccctgaggc tgcctcccca gcacccaacc cggactggct ctcagctgct     8400

gcactgcact ttgcgattca acaagtcagg gaagaaaaca tcaggaagca gctaaagaag     8460

ctggactgcg agagagagga gctattggtt ttccttttct tcttctcctt gatgggcctg     8520

ctgtcgtcac atctgacctc aaatagcacc acagacctgc caaaggcttt ccacgtttgt     8580

gcagcaatcc tcgagtgttt agagaagagg aagatatcct ggctggcact ctttcagttg     8640

acagagagtg acctcaggct ggggcggctc ctcctccgtg tggccccgga tcagcacacc     8700

aggctgctgc ctttcgcttt ttacagtctt ctctcctact tccatgaaga cgcggccatc     8760

agggaagagg ccttcctgca tgttgctgtg gacatgtact tgaagctggt ccagctcttc     8820

gtggctgggg atacaagcac agtttcacct ccagctggca ggagcctgga gctcaagggt     8880

cagggcaacc ccgtggaact gataacaaaa gctcgtcttt ttctgctgca gttaatacct     8940

cggtgcccga aaaagagctt ctcacacgtg gcagagctgc tggctgatcg tggggactgc     9000

gacccagagg tgagcgccgc cctccagagc agacagcagg ctgcccctga cgctgacctg     9060

tcccaggagc ctcatctctt ctgacgggac ctgccactgc acaccagccc agctcccgtg     9120

taaataattt attacaagca taacatggag ctcttgttgc actaaaaagt ggattacaaa     9180

tctcctcgac tgctttagtg gggaaaggaa tcaattattt atgaactgtc cggccccgag     9240

tcactcagcg tttgcgggaa aataaaccac tggtcccaga gcagaggaag gctacttgag     9300

ccggacacca agcccgcctc cagcaccaag ggcgggcagc accctccgac cctcccatgc     9360

gggtgcacac gaagggtgag gctgacacag ccactgcgga gtccaggctg ctagaggtgc     9420

tcatcctcac tgccgtcctc aggtgggttc gggcttcacc gcctggccct ctgtggtcac     9480

agaggggctc ggtggcccag gtggtggttc cgcctccagg ggcagggcct tgtcctgggt     9540

ctgtgtcagc gggtgcacca tggacatgtg tacaagtaaa gcggccgcgt cgacaatcaa     9600

cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt     9660

acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct     9720

ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc     9780

gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg     9840

ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc     9900

acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc     9960

actgacaatt ccgtggtgtt gtcggggaag ctgacgtcct ttccatggct gctcgcctgt    10020

gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca    10080

gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt    10140

cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcctggaat tcgagctcgg    10200

tacctttaag accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa    10260

aggggggact ggaagggcta attcactccc aacgaagaca agatctgctt tttgcttgta    10320

ctgggtctct ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc    10380

cactgcttaa gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt    10440

tgtgtgactc tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta    10500

gcagtagtag ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat    10560

cagagagtga gaggaacttg tttattgcag cttataatgg ttacaaataa agcaatagca    10620

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac    10680

tcatcaatgt atcttatcat gtctggctct agctatcccg cccctaactc cgcccagttc    10740

cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc    10800

ctcggcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg    10860

cgtcgagacg tacccaattc gccctatagt gagtcgtatt acgcgcgctc actggccgtc    10920

gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca    10980

catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa    11040

cagttgcgca gcctgaatgg cgaatggcgc gacgcgccct gtagcggcgc attaagcgcg    11100

gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct    11160

cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta    11220

aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa    11280

cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct    11340

ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc    11400

aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg    11460

ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgttt    11520

acaatttcc                                                            11529


<210>  32
<211>  4904
<212>  DNA
<213>  artificial

<220>
<223>  PGK promoter associated with FANCA gene

<400>  32
ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc       60

tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc      120

cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc      180

tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac      240

ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc      300

gcgccgaccg cgatgggctg tggccaatag cggctgctca gcggggcgcg ccgagagcag      360

cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct      420

gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct      480

cgttgaccga atcaccgacc tctctcccca gggggatcca ccggtccgcc aaggccatgt      540

ccgactcgtg ggtcccgaac tccgcctcgg gccaggaccc agggggccgc cggagggcct      600

gggccgagct gctggcggga agggtcaaga gggaaaaata taatcctgaa agggcacaga      660

aattaaagga atcagctgtg cgcctcctgc gaagccatca ggacctgaat gcccttttgc      720

ttgaggtaga aggtccactg tgtaaaaaat tgtctctcag caaagtgatt gactgtgaca      780

gttctgaggc ctatgctaat cattctagtt catttatagg ctctgctttg caggatcaag      840

cctcaaggct gggggttccc gtgggtattc tctcagccgg gatggttgcc tctagcgtgg      900

gacagatctg cacggctcca gcggagacca gtcaccctgt gctgctgact gtggagcaga      960

gaaagaagct gtcttccctg ttagagtttg ctcagtattt attggcacac agtatgttct     1020

cccgtctttc cttctgtcaa gaattatgga aaatacagag ttctttgttg cttgaagcgg     1080

tgtggcatct tcacgtacaa ggcattgtga gcctgcaaga gctgctggaa agccatcccg     1140

acatgcatgc tgtgggatcg tggctcttca ggaatctgtg ctgcctttgt gaacagatgg     1200

aagcatcctg ccagcatgct gacgtcgcca gggccatgct ttctgatttt gttcaaatgt     1260

ttgttttgag gggatttcag aaaaactcag atctgagaag aactgtggag cctgaaaaaa     1320

tgccgcaggt cacggttgat gtactgcaga gaatgctgat ttttgcactt gacgctttgg     1380

ctgctggagt acaggaggag tcctccactc acaagatcgt gaggtgctgg ttcggagtgt     1440

tcagtggaca cacgcttggc agtgtaattt ccacagatcc tctgaagagg ttcttcagtc     1500

ataccctgac tcagatactc actcacagcc ctgtgctgaa agcatctgat gctgttcaga     1560

tgcagagaga gtggagcttt gcgcggacac accctctgct cacctcactg taccgcaggc     1620

tctttgtgat gctgagtgca gaggagttgg ttggccattt gcaagaagtt ctggaaacgc     1680

aggaggttca ctggcagaga gtgctctcct ttgtgtctgc cctggttgtc tgctttccag     1740

aagcgcagca gctgcttgaa gactgggtgg cgcgtttgat ggcccaggca ttcgagagct     1800

gccagctgga cagcatggtc actgcgttcc tggttgtgcg ccaggcagca ctggagggcc     1860

cctctgcgtt cctgtcatat gcagactggt tcaaggcctc ctttgggagc acacgaggct     1920

accatggctg cagcaagaag gccctggtct tcctgtttac gttcttgtca gaactcgtgc     1980

cttttgagtc tccccggtac ctgcaggtgc acattctcca cccacccctg gttcccagca     2040

agtaccgctc cctcctcaca gactacatct cattggccaa gacacggctg gccgacctca     2100

aggtttctat agaaaacatg ggactctacg aggatttgtc atcagctggg gacattactg     2160

agccccacag ccaagctctt caggatgttg aaaaggccat catggtgttt gagcatacgg     2220

ggaacatccc agtcaccgtc atggaggcca gcatattcag gaggccttac tacgtgtccc     2280

acttcctccc cgccctgctc acacctcgag tgctccccaa agtccctgac tcccgtgtgg     2340

cgtttataga gtctctgaag agagcagata aaatcccccc atctctgtac tccacctact     2400

gccaggcctg ctctgctgct gaagagaagc cagaagatgc agccctggga gtgagggcag     2460

aacccaactc tgctgaggag cccctgggac agctcacagc tgcactggga gagctgagag     2520

cctccatgac agaccccagc cagcgtgatg ttatatcggc acaggtggca gtgatttctg     2580

aaagactgag ggctgtcctg ggccacaatg aggatgacag cagcgttgag atatcaaaga     2640

ttcagctcag catcaacacg ccgagactgg agccacggga acacattgct gtggacctcc     2700

tgctgacgtc tttctgtcag aacctgatgg ctgcctccag tgtcgctccc ccggagaggc     2760

agggtccctg ggctgccctc ttcgtgagga ccatgtgtgg acgtgtgctc cctgcagtgc     2820

tcacccggct ctgccagctg ctccgtcacc agggcccgag cctgagtgcc ccacatgtgc     2880

tggggttggc tgccctggcc gtgcacctgg gtgagtccag gtctgcgctc ccagaggtgg     2940

atgtgggtcc tcctgcacct ggtgctggcc ttcctgtccc tgcgctcttt gacagcctcc     3000

tgacctgtag gacgagggat tccttgttct tctgcctgaa attttgtaca gcagcaattt     3060

cttactctct ctgcaagttt tcttcccagt cacgagatac tttgtgcagc tgcttatctc     3120

caggccttat taaaaagttt cagttcctca tgttcagatt gttctcagag gcccgacagc     3180

ctctttctga ggaggacgta gccagccttt cctggagacc cttgcacctt ccttctgcag     3240

actggcagag agctgccctc tctctctgga cacacagaac cttccgagag gtgttgaaag     3300

aggaagatgt tcacttaact taccaagact ggttacacct ggagctggaa attcaacctg     3360

aagctgatgc tctttcagat actgaacggc aggacttcca ccagtgggcg atccatgagc     3420

actttctccc tgagtcctcg gcttcagggg gctgtgacgg agacctgcag gctgcgtgta     3480

ccattcttgt caacgcactg atggatttcc accaaagctc aaggagttat gaccactcag     3540

aaaattctga tttggtcttt ggtggccgca caggaaatga ggatattatt tccagattgc     3600

aggagatggt agctgacctg gagctgcagc aagacctcat agtgcctctc ggccacaccc     3660

cttcccagga gcacttcctc tttgagattt tccgcagacg gctccaggct ctgacaagcg     3720

ggtggagcgt ggctgccagc cttcagagac agagggagct gctaatgtac aaacggatcc     3780

tcctccgcct gccttcgtct gtcctctgcg gcagcagctt ccaggcagaa cagcccatca     3840

ctgccagatg cgagcagttc ttccacttgg tcaactctga gatgagaaac ttctgctccc     3900

acggaggtgc cctgacacag gacatcactg cccacttctt caggggcctc ctgaacgcct     3960

gtctgcggag cagagacccc tccctgatgg tcgacttcat actggccaag tgccagacga     4020

aatgcccctt aattttgacc tctgctctgg tgtggtggcc gagcctggag cctgtgctgc     4080

tctgccggtg gaggagacac tgccagagcc cgctgccccg ggaactgcag aagctacaag     4140

aaggccggca gtttgccagc gatttcctct cccctgaggc tgcctcccca gcacccaacc     4200

cggactggct ctcagctgct gcactgcact ttgcgattca acaagtcagg gaagaaaaca     4260

tcaggaagca gctaaagaag ctggactgcg agagagagga gctattggtt ttccttttct     4320

tcttctcctt gatgggcctg ctgtcgtcac atctgacctc aaatagcacc acagacctgc     4380

caaaggcttt ccacgtttgt gcagcaatcc tcgagtgttt agagaagagg aagatatcct     4440

ggctggcact ctttcagttg acagagagtg acctcaggct ggggcggctc ctcctccgtg     4500

tggccccgga tcagcacacc aggctgctgc ctttcgcttt ttacagtctt ctctcctact     4560

tccatgaaga cgcggccatc agggaagagg ccttcctgca tgttgctgtg gacatgtact     4620

tgaagctggt ccagctcttc gtggctgggg atacaagcac agtttcacct ccagctggca     4680

ggagcctgga gctcaagggt cagggcaacc ccgtggaact gataacaaaa gctcgtcttt     4740

ttctgctgca gttaatacct cggtgcccga aaaagagctt ctcacacgtg gcagagctgc     4800

tggctgatcg tggggactgc gacccagagg tgagcgccgc cctccagagc agacagcagg     4860

ctgcccctga cgctgacctg tcccaggagc ctcatctctt ctga                      4904


<210>  33
<211>  12265
<212>  DNA
<213>  artificial

<220>
<223>  synthetic foamy virus vector containing PGK promoter associated 
       with FancA gene

<400>  33
tcgcgcgttc tcgaggagct tggcccattg catacgttgt atccatatca taatatgtac       60

atttatattg gctcatgtcc aacattaccg ccatgttgac attgattatt gactagttat      120

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca      180

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca      240

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg      300

gagtatttac gctaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg      360

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc      420

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg      480

atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca      540

agtctccacc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      600

cagagcttct agattgtacg ggagctctct cttcactact cgctgcgtcg agagtgtacg      660

agactctcca ggtttggtaa gaaatatttt atattgttat aatgttacta tgatccatta      720

acactctgct tatagattgt aagggtgatt gcaatgcttt ctgcataaaa ctttggtttt      780

cttgttaatc aataaaccga cttgattcga gaacctactc atatattatt gtctctttta      840

tactttatta agtaaaagga tttgtatatt agccttgcta agggagacat ctagtgatat      900

aagtgtgaac tacacttatc ttaaatgatg taactcctta ggataatcaa tatacaaaat      960

tccatgacaa ttggcgccca acgtggggct cgaatataag tcgggtttat ttgtaaatta     1020

tccctaggga cctccgagca tagcgggagg catataaaag ccaatagaca atggctagca     1080

ggaagtaatg ttgaagaata tgaacttgat gttgaagctc tggttgtaat tttaagagat     1140

agaaatatac caagaaatcc tttacatgga gaagttatag gtcttcgcct tactgaagga     1200

tggtggggac aaattgagag atttcagatg gtacgttgat tcgaattaag gctatggatt     1260

tggccatggg acaagaaata ttagtttata gtcccattgt atctatgact aaaatacaaa     1320

aaactccact accagaaaga aaagctttac ccattagatg gataacatgg atgacttatt     1380

tagaagatcc aagaatccaa tttcattatg ataaaacctt accagaactt aagcatattc     1440

cagatgtata tacatctagt cagtctcctg ttaaacatcc ttctcaatat gaaggagtgt     1500

tttatactga tggctcggcc atcaaaagtc ctgatcctac aaaaagcaat aatgctggca     1560

tgggaatagt acatgccaca tacaaacctg aatatcaagt tttgaatcaa tggtcaatac     1620

cactaggtaa tcatactgct cagatggctg aaatagctgc agttgaattt gcctgtaaaa     1680

aagctttaaa aatacctggt cctgtattag ttataactga tagtttctat gtagcagaaa     1740

gtgctaataa agaattacca tactggaaat ctaatgggtt tgttaataat aagaaaaagc     1800

ctcttaaaca tatctccaaa tggaaatcta ttgctgagtg tttatctatg aaaccagaca     1860

ttactattca acatgaaaaa ggcatcagcc tacaaatacc agtattcata ctgaaaggca     1920

atgccctagc agataagctt gccacccaag gaagttatgt ggttaattgt aataccaaaa     1980

aaccaaacct ggatgcagag ttggatcaat tattacaggg tcattatata aaaggatatc     2040

ccaaacaata tacatatttt ttagaagatg gcaaagtaaa agtttccaga cctgaagggg     2100

ttaaaattat tccccctcag tcagacagac aaaaaattgt gcttcaagcc cacaatttgg     2160

ctcacaccgg acgtgaagcc actcttttaa aaattgccaa cctttattgg tggccaaata     2220

tgagaaagga tgtggttaaa caactaggac gctgtcaaca gtgtttaatc acaaatgctt     2280

ccaacaaagc ctctggtcct attctaagac cagataggcc tcaaaaacct tttgataaat     2340

tctttattga ctatattgga cctttgccac cttcacaggg atacctatat gtattagtag     2400

ttgttgatgg aatgacagga ttcacttggt tataccccac taaggctcct tctactagcg     2460

caactgttaa atctctcaat gtactcacta gtattgcaat tccaaaggtg attcactctg     2520

atcaaggtgc agcattcact tcttcaacct ttgctgaatg ggcaaaggaa agaggtatac     2580

atttggaatt cagtactcct tatcaccccc aaagtggtag taaggtggaa aggaaaaata     2640

gtgatataaa acgactttta actaaactgc tagtaggaag acccacaaag tggtatgacc     2700

tattgcctgt tgtacaactt gctttaaaca acacctatag ccctgtatta aaatatactc     2760

cacatcaact cttatttggt atagattcaa atactccatt tgcaaatcaa gatacacttg     2820

acttgaccag agaagaagaa ctttctcttt tacaggaaat tcgtacttct ttataccatc     2880

catccacccc tccagcctcc tctcgttcct ggtctcctgt tgttggccaa ttggtccagg     2940

agagggtggc taggcctgct tctttgagac ctcgttggca taaaccgtct actgtactta     3000

aggtgttgaa tccaaggact gttgttattt tggaccatct tggcaacaac agaactgtaa     3060

gtatagataa tttaaaacct acttctcatc agaatggcac caccaatgac actgcaacaa     3120

tggatcattt ggaaaaaaat gaataaagcg catgaggcac ttcaaaatac aacaactgtg     3180

actgaacagc agaaggaaca aattatactg gacattcaaa atgaagaagt acaaccaact     3240

aggagagata aatttagata tctgctttat acttgttgtg ctactagctc aagagtattg     3300

gcctggatgt ttttagtttg tatattgtta atcattgttt tggtttcatg ctttgtgact     3360

atatccagaa tacaatggaa taaggatatt caggtattag gacctgtaat agactggaat     3420

gttactcaaa gagctgttta tcaaccctta cagactagaa ggattgcacg ttcccttaga     3480

atgcagcatc ctgttccaaa atatgtggag gtaaatatga ctagtattcc acaaggtgta     3540

tactatgaac cccatccggc gcgccagatc tgcatgccac ggggttgggg ttgcgccttt     3600

tccaaggcag ccctgggttt gcgcagggac gcggctgctc tgggcgtggt tccgggaaac     3660

gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc cgttcgcagc gtcacccgga     3720

tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc tgctccgccc ctaagtcggg     3780

aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac ggaagccgca cgtctcacta     3840

gtaccctcgc agacggacag cgccagggag caatggcagc gcgccgaccg cgatgggctg     3900

tggccaatag cggctgctca gcggggcgcg ccgagagcag cggccgggaa ggggcggtgc     3960

gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct gcccgcgcgg tgttccgcat     4020

tctgcaagcc tccggagcgc acgtcggcag tcggctccct cgttgaccga atcaccgacc     4080

tctctcccca gggggatcca ccggtccgcc aaggccatgt ccgactcgtg ggtcccgaac     4140

tccgcctcgg gccaggaccc agggggccgc cggagggcct gggccgagct gctggcggga     4200

agggtcaaga gggaaaaata taatcctgaa agggcacaga aattaaagga atcagctgtg     4260

cgcctcctgc gaagccatca ggacctgaat gcccttttgc ttgaggtaga aggtccactg     4320

tgtaaaaaat tgtctctcag caaagtgatt gactgtgaca gttctgaggc ctatgctaat     4380

cattctagtt catttatagg ctctgctttg caggatcaag cctcaaggct gggggttccc     4440

gtgggtattc tctcagccgg gatggttgcc tctagcgtgg gacagatctg cacggctcca     4500

gcggagacca gtcaccctgt gctgctgact gtggagcaga gaaagaagct gtcttccctg     4560

ttagagtttg ctcagtattt attggcacac agtatgttct cccgtctttc cttctgtcaa     4620

gaattatgga aaatacagag ttctttgttg cttgaagcgg tgtggcatct tcacgtacaa     4680

ggcattgtga gcctgcaaga gctgctggaa agccatcccg acatgcatgc tgtgggatcg     4740

tggctcttca ggaatctgtg ctgcctttgt gaacagatgg aagcatcctg ccagcatgct     4800

gacgtcgcca gggccatgct ttctgatttt gttcaaatgt ttgttttgag gggatttcag     4860

aaaaactcag atctgagaag aactgtggag cctgaaaaaa tgccgcaggt cacggttgat     4920

gtactgcaga gaatgctgat ttttgcactt gacgctttgg ctgctggagt acaggaggag     4980

tcctccactc acaagatcgt gaggtgctgg ttcggagtgt tcagtggaca cacgcttggc     5040

agtgtaattt ccacagatcc tctgaagagg ttcttcagtc ataccctgac tcagatactc     5100

actcacagcc ctgtgctgaa agcatctgat gctgttcaga tgcagagaga gtggagcttt     5160

gcgcggacac accctctgct cacctcactg taccgcaggc tctttgtgat gctgagtgca     5220

gaggagttgg ttggccattt gcaagaagtt ctggaaacgc aggaggttca ctggcagaga     5280

gtgctctcct ttgtgtctgc cctggttgtc tgctttccag aagcgcagca gctgcttgaa     5340

gactgggtgg cgcgtttgat ggcccaggca ttcgagagct gccagctgga cagcatggtc     5400

actgcgttcc tggttgtgcg ccaggcagca ctggagggcc cctctgcgtt cctgtcatat     5460

gcagactggt tcaaggcctc ctttgggagc acacgaggct accatggctg cagcaagaag     5520

gccctggtct tcctgtttac gttcttgtca gaactcgtgc cttttgagtc tccccggtac     5580

ctgcaggtgc acattctcca cccacccctg gttcccagca agtaccgctc cctcctcaca     5640

gactacatct cattggccaa gacacggctg gccgacctca aggtttctat agaaaacatg     5700

ggactctacg aggatttgtc atcagctggg gacattactg agccccacag ccaagctctt     5760

caggatgttg aaaaggccat catggtgttt gagcatacgg ggaacatccc agtcaccgtc     5820

atggaggcca gcatattcag gaggccttac tacgtgtccc acttcctccc cgccctgctc     5880

acacctcgag tgctccccaa agtccctgac tcccgtgtgg cgtttataga gtctctgaag     5940

agagcagata aaatcccccc atctctgtac tccacctact gccaggcctg ctctgctgct     6000

gaagagaagc cagaagatgc agccctggga gtgagggcag aacccaactc tgctgaggag     6060

cccctgggac agctcacagc tgcactggga gagctgagag cctccatgac agaccccagc     6120

cagcgtgatg ttatatcggc acaggtggca gtgatttctg aaagactgag ggctgtcctg     6180

ggccacaatg aggatgacag cagcgttgag atatcaaaga ttcagctcag catcaacacg     6240

ccgagactgg agccacggga acacattgct gtggacctcc tgctgacgtc tttctgtcag     6300

aacctgatgg ctgcctccag tgtcgctccc ccggagaggc agggtccctg ggctgccctc     6360

ttcgtgagga ccatgtgtgg acgtgtgctc cctgcagtgc tcacccggct ctgccagctg     6420

ctccgtcacc agggcccgag cctgagtgcc ccacatgtgc tggggttggc tgccctggcc     6480

gtgcacctgg gtgagtccag gtctgcgctc ccagaggtgg atgtgggtcc tcctgcacct     6540

ggtgctggcc ttcctgtccc tgcgctcttt gacagcctcc tgacctgtag gacgagggat     6600

tccttgttct tctgcctgaa attttgtaca gcagcaattt cttactctct ctgcaagttt     6660

tcttcccagt cacgagatac tttgtgcagc tgcttatctc caggccttat taaaaagttt     6720

cagttcctca tgttcagatt gttctcagag gcccgacagc ctctttctga ggaggacgta     6780

gccagccttt cctggagacc cttgcacctt ccttctgcag actggcagag agctgccctc     6840

tctctctgga cacacagaac cttccgagag gtgttgaaag aggaagatgt tcacttaact     6900

taccaagact ggttacacct ggagctggaa attcaacctg aagctgatgc tctttcagat     6960

actgaacggc aggacttcca ccagtgggcg atccatgagc actttctccc tgagtcctcg     7020

gcttcagggg gctgtgacgg agacctgcag gctgcgtgta ccattcttgt caacgcactg     7080

atggatttcc accaaagctc aaggagttat gaccactcag aaaattctga tttggtcttt     7140

ggtggccgca caggaaatga ggatattatt tccagattgc aggagatggt agctgacctg     7200

gagctgcagc aagacctcat agtgcctctc ggccacaccc cttcccagga gcacttcctc     7260

tttgagattt tccgcagacg gctccaggct ctgacaagcg ggtggagcgt ggctgccagc     7320

cttcagagac agagggagct gctaatgtac aaacggatcc tcctccgcct gccttcgtct     7380

gtcctctgcg gcagcagctt ccaggcagaa cagcccatca ctgccagatg cgagcagttc     7440

ttccacttgg tcaactctga gatgagaaac ttctgctccc acggaggtgc cctgacacag     7500

gacatcactg cccacttctt caggggcctc ctgaacgcct gtctgcggag cagagacccc     7560

tccctgatgg tcgacttcat actggccaag tgccagacga aatgcccctt aattttgacc     7620

tctgctctgg tgtggtggcc gagcctggag cctgtgctgc tctgccggtg gaggagacac     7680

tgccagagcc cgctgccccg ggaactgcag aagctacaag aaggccggca gtttgccagc     7740

gatttcctct cccctgaggc tgcctcccca gcacccaacc cggactggct ctcagctgct     7800

gcactgcact ttgcgattca acaagtcagg gaagaaaaca tcaggaagca gctaaagaag     7860

ctggactgcg agagagagga gctattggtt ttccttttct tcttctcctt gatgggcctg     7920

ctgtcgtcac atctgacctc aaatagcacc acagacctgc caaaggcttt ccacgtttgt     7980

gcagcaatcc tcgagtgttt agagaagagg aagatatcct ggctggcact ctttcagttg     8040

acagagagtg acctcaggct ggggcggctc ctcctccgtg tggccccgga tcagcacacc     8100

aggctgctgc ctttcgcttt ttacagtctt ctctcctact tccatgaaga cgcggccatc     8160

agggaagagg ccttcctgca tgttgctgtg gacatgtact tgaagctggt ccagctcttc     8220

gtggctgggg atacaagcac agtttcacct ccagctggca ggagcctgga gctcaagggt     8280

cagggcaacc ccgtggaact gataacaaaa gctcgtcttt ttctgctgca gttaatacct     8340

cggtgcccga aaaagagctt ctcacacgtg gcagagctgc tggctgatcg tggggactgc     8400

gacccagagg tgagcgccgc cctccagagc agacagcagg ctgcccctga cgctgacctg     8460

tcccaggagc ctcatctctt ctgacgggac ctgccactgc acaccagccc agctcccgtg     8520

taaataattt attacaagca taacatggag ctcttgttgc actaaaaagt ggattacaaa     8580

tctcctcgac tgctttagtg gggaaaggaa tcaattattt atgaactgtc cggccccgag     8640

tcactcagcg tttgcgggaa aataaaccac tggtcccaga gcagaggaag gctacttgag     8700

ccggacacca agcccgcctc cagcaccaag ggcgggcagc accctccgac cctcccatgc     8760

gggtgcacac gaagggtgag gctgacacag ccactgcgga gtccaggctg ctagaggtgc     8820

tcatcctcac tgccgtcctc aggtgggttc gggcttcacc gcctggccct ctgtggtcac     8880

agaggggctc ggtggcccag gtggtggttc cgcctccagg ggcagggcct tgtcctgggt     8940

ctgtgtcagc gggtgcacca tggacatgtg tacaagtaaa gcggccgcgt cgagggctgc     9000

aggaattcga gcatcttacc gccatttatt cccatatttg ttctgttttt cttgatttgg     9060

gtatacattt aaatgttaat aaaacaaaat ggtggggcaa tcatttacat ttttagggat     9120

atgtaattac tagttcaggt gtattgccac aagacaaaca tgttaagaaa ctttcccgtt     9180

atttacgctc tgttcctgtt aatcaacctc tggattacaa aatttgtgaa agattgactg     9240

atattcttaa ctatgttgct ccttttacgc tgtgtggata tgctgcttta tagcctctgt     9300

atctagctat tgcttcccgt acggctttcg ttttctcctc cttgtataaa tcctggttgc     9360

tgtctctttt agaggagttg tggcccgttg tccgtcaacg tggcgtggtg tgctctgtgt     9420

ttgctgacgc aacccccact ggctggggca ttgccaccac ctgtcaactc ctttctggga     9480

ctttcgcttt ccccctcccg atcgccacgg cagaactcat cgccgcctgc cttgcccgct     9540

gctggacagg ggctaggttg ctgggcactg ataattccgt ggtgttgtcg gggaagctga     9600

cgtcctttcg aattcgatat caagcttatc gataccgtcg acggttacca agcagctatg     9660

gaagcttatg gacctcagag aggaagtaac gaggagaggg tgtggtggaa tgccactaga     9720

aaccagggaa aacaaggagg agagtattac agggaaggag gtgaagaacc tcattaccca     9780

aatactcctg ctcctcatag acgtacctgg gatgagagac acaaggttct taaattgtcc     9840

tcattcgcta ctccctctga catccaacgc tgggctacta actctagatt gtacgggagc     9900

tctcttcact actcgctgcg tcgagagtgt acgagactct ccaggtttgg taagaaatat     9960

tttatattgt tataatgtta ctatgatcca ttaacactct gcttatagat tgtaagggtg    10020

attgcaatgc tttctgcata aaactttggt tttcttgtta atcaataaac cgacttgatt    10080

cgagaaccta ctcatatatt attgtctctt ttatacttta ttaagtaaaa ggatttgtat    10140

attagccttg ctaagggaga catctagtga tataagtgtg aactacactt atcttaaatg    10200

atgtaactcc ttaggataat caatatacaa aattccatga caattggcga tacccagctg    10260

cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg    10320

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga    10380

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg    10440

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag    10500

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc    10560

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg    10620

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt    10680

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc    10740

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc    10800

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg    10860

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca    10920

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc    10980

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat    11040

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt    11100

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt    11160

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc    11220

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc    11280

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata    11340

ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg    11400

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc    11460

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct    11520

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa    11580

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt    11640

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca    11700

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac    11760

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca    11820

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt    11880

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc    11940

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca    12000

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata    12060

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc    12120

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc    12180

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat    12240

aggcgtatca cgaggccctt tcgtc                                          12265


<210>  34
<211>  175
<212>  PRT
<213>  artificial

<220>
<223>  synthetic granulocyte colony stimulating factor (G-CSF) 
       filgrastim

<400>  34

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  35
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  36
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  37
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 
65                  70                  75                  80  


Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 
                85                  90                  95      


Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 
            100                 105                 110         


Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 
        115                 120                 125             


Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 
    130                 135                 140                 


Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 
145                 150                 155                 160 


Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170     


<210>  38
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  39
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  40
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  forward primer for mCherry

<400>  40
gatccaccgg tcgccaccat g                                                 21


<210>  41
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer for mCherry

<400>  41
gtcgacgcgg ccgctttact tg                                                22


<210>  42
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  forward primer for EF1a-mCherry

<400>  42
actgcatgcc gatggctccg gtgcccgtc                                         29


<210>  43
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  EF1a-F-NotI forward primer for EF1a-GFP

<400>  43
attagcggcc gcaggctccg gtgcccgtca gt                                     32


<210>  44
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  GFP-R-NotI reverse primer for EF1a-GFP

<400>  44
attagcggcc gcttacttgt acagctcgtc catg                                   34


