                         LISTADO DE SECUENCIAS

<110>  Instituto de Salud Carlos III
 
<120>  Uso de moduladores de la funcin de CD69 para la movilizacin y 
       proliferacin de precursores hematopoyticos

<130>  PCT1613.8

<150> ES P201730207
<151> 2017-02-20

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210>  2
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  2
caagagctcc agcaaagact ttcactgtag cttgacttga cctgagatta actagggaat       60

cttgagaata aagatgagct ctgaaaattg tttcgtagca gagaacagct ctttgcatcc      120

ggagagtgga caagaaaatg atgccaccag tccccatttc tcaacacgtc atgaagggtc      180

cttccaagtt cctgtcctgt gtgctgtaat gaatgtggtc ttcatcacca ttttaatcat      240

agctctcatt gccttatcag tgggccaata caattgtcca ggccaataca cattctcaat      300

gccatcagac agccatgttt cttcatgctc tgaggactgg gttggctacc agaggaaatg      360

ctactttatt tctactgtga agaggagctg gacttcagcc caaaatgctt gttctgaaca      420

tggtgctact cttgctgtca ttgattctga aaaggacatg aactttctaa aacgatacgc      480

aggtagagag gaacactggg ttggactgaa aaaggaacct ggtcacccat ggaagtggtc      540

aaatggcaaa gaatttaaca actggttcaa cgttacaggg tctgacaagt gtgtttttct      600

gaaaaacaca gaggtcagca gcatggaatg tgagaagaat ttatactgga tatgtaacaa      660

accttacaaa taataaggaa acgtgttcac ttattgacta ttatagaatg gaactcaagg      720

aaatctgtgt cagtggatgc tgctctgtgg tccgaagtct tccatagaga ctttgtgaaa      780

aaaaatttta tagtgtcttg ggaattttct tccaaacaga actatggaaa aaaaggaaga      840

aattccagga aaatctgcac ttgtggcttt tattgccatg agctagaagc atcacaggtt      900

gaccaataac catgcccaag aatgagaaga atgactatgc aacctttgga tgcactttat      960

attattttga atccagaaat aatgaaataa ctaggcgtgg acttactatt aattgctgaa     1020

tgactaccaa cagtgagagc ccttcatgca tttgcactat tggaaggagt tagatgttgg     1080

tactagatac tgaatgtaaa caaaggaatt atggctggta acatagtttt tagtctaatt     1140

gaatccctta aactcaggga gcatttataa atggcaaatg cttatgaaac taagatttgt     1200

aatatttctc tctttttaga gaaatttgcc aatttacttt gttatttttc cccaaaaaga     1260

atgggatgat cgtgtattta tttttttact tcctcagctg tagacaggtc cttttcgatg     1320

gtacatattt ctttgccttt ataatctttt atacagtgtc ttacagagaa aagacataag     1380

caaagactat gaggaatatt tgcaagacat agaatagtgt tggaaaatgt gcaatatgtg     1440

atgtggcaaa tctctattag gaaatattct gtaatcttca gacctagaat aatactagtc     1500

ttataatagg tttgtgactt tcctaaatca attctattac gtgcaatact tcaatacttc     1560

atttaaaata tttttatgtg caataaaatg tatttgtttg tattttgtgt tcagtacaat     1620

tataagctgt ttttatatat gtgaaataaa agtagaataa ac                        1662


<210>  3
<211>  10
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-H1 de la cadena pesada del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  3

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-H2 de la cadena pesada del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  4

Asn Ile Tyr Pro Gly Ser Gly Thr Ala Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  5
<211>  10
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-H3 de la cadena pesada del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  5

Ser Asn Trp Asp Glu Thr Trp Phe Ala Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-L1 de la cadena ligera del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  6

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-L2 de la cadena ligera del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  7

Asn Ala Lys Ile Leu Val Glu 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Regin variable CDR-L3 de la cadena ligera del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  8

Gln His His Tyr Gly Ser Pro Tyr Thr 
1               5                   


<210>  9
<211>  121
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Secuencia comprendida en la cadena pesada del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  9

Gly Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
            20                  25                  30          


Met His Trp Val Lys Gln Arg His Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Tyr Pro Gly Ser Gly Thr Ala Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Asn Lys Gly Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ile 
                85                  90                  95      


Arg Ser Asn Trp Asp Glu Thr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Ser Gly 
        115                 120     


<210>  10
<211>  114
<212>  PRT
<213>  Secuencia Artificial

<220>
<223>  Secuencia comprendida en la cadena ligera del anticuerpo 
       monoclonal 2.9 frente a CD69

<400>  10

Ala Met Ala Asp Tyr Lys Asp Ile Gln Ile Asn Gln Ser Pro Ala Ser 
1               5                   10                  15      


Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25                  30          


Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Glu 
        35                  40                  45              


Ser Pro Gln Leu Leu Val Tyr Asn Ala Lys Ile Leu Val Glu Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Gln Phe Ser Leu Lys 
65                  70                  75                  80  


Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His 
                85                  90                  95      


His Tyr Gly Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


