﻿               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

<120> ALTERNATIVE ACTIVATION OF MACROPHAGES (M2 CELLS) THROUGH THE POLYAMINE-eIF5a-HYPUSINE AXIS

<130> Z2400 PCT  

<150> US62/459,833
<151> 2017-02-16

<160> 10

<170> BiSSAP 1.3

<210> 1
<211> 9373
<212> DNA
<213> Homo sapiens

<220> 
<223> Human Ornithine Decarboxylase full nucleotide sequence

<400> 1
tccattcatt catttatgca tgcattcatt aaacaggtat tcactgactg tgcctcagac       60

ctggttttgg gtaccaagga agtttttcaa aacctcacag ggctttgtag ctataaagat      120

atgtaaggat ccttgggtta tctgaagccc agagaaggga gataacttgt ccaagagcac      180

acagcaagtt gggggcagcg ctgggccagt gctctgagct cctccaaccc cgcccccacc      240

cacccaaggc tagatctaga tctacccact cctctcctta actcttcatc ggctgtactc      300

ccaccctaag gagtcgaaat ccccacccta gggagagaca tatcctgtct ggattgtcca      360

aaagggaatg aaaggtaaaa atgaaaaaaa aaaaaaaagt gtccccaatt caagtgcagt      420

gcctccctgg tgcgggcatt ccagcgtggc ctggagtgag tggcagtcca cctccagagg      480

cgtcccctgg gcgctcctag ggactcgaat ttcccacgcg gctttttgct ttatgtattc      540

actgtttaga cgttttcggt caaagcattt tgggacttcc gtaactctca gagcgcgcca      600

gggagccgcc cttaaagata cctagttact gatgagttcc atccggtaaa gcagagggta      660

gtgggcggct tggagactca ggatccgggt cccctcacgc tcctggctga gtccctggct      720

tcacagggga aactacctcc gcaggccagg acccatctag ttacaggata cctcgatgtt      780

acaaagacga ggcttccagc gcgggggcgt ggaggcggct gccagccctg cccgcagcgt      840

gctggcgacc cccgggacgc cccttccctc ccgcgcctct gctccctagc tggtgggagc      900

agagcgcacc gggatcactt ccaggtccct tgcaccggag gaatgggcgg cagcagggtc      960

cggagtcggc ccggcggggc ccacgtggcc agcacatcgg tcctccgctc gcgatttccc     1020

ttttccgctc tcgggcacga ggtactgaac gccaggtgga agcacagctg tgcagctaca     1080

ggctctgccg ttcagctgcc gcgggccggg gccggggcct gcggcgtcgt gcgcgtgcgc     1140

ggaccagttc caggcgggcg agaccgccgc agggcggggc ggggcgaggc ggccgcaggg     1200

cggggagggc ggggagaggc ggccgcaggg cggggagggc ggggcgcgaa gccgggggcg     1260

ggggccacgc gtggggcagg cggtgctcgg ctcggctgac gtcggcccgc cggcgcccca     1320

ccagctccgc gcgggcccgg gttggccacc gccgggcccc cgcccctccc ccggccgtgt     1380

cccggccgga accgatcgtg gctggtttga gctggtgcgt ctccatggcg acccgccggt     1440

gctataagta gggagcggcg tgccgtgggg ctttgtcagt ccctcctgta gccgccgccg     1500

ccgccgcccg ccgcccctct gccagcagct ccggcgccac ctcgggccgg cgtctccggc     1560

gggcgggagc caggcgctga cgggcgcggc gggggcggcc gagcgctcct gcggctgcga     1620

ctcaggctcc ggcgtctgcg cttccccatg gggctggcct gcggcgcctg ggcgctctga     1680

ggtgagggac tccccggccg cggaggaagg gagggagcga gggcgggagc ggggcgggct     1740

gcgggccccg ggccccgggc acgtgtgcgg cgcgcctcgc cggcctgcag agacacgtgg     1800

tcgccgagcg ggccacgacc ttgaggcgcc gcttcctccc ggcccggggt tctcccgcgg     1860

ctggataagg gtgatccggg cgcctcgttc tgcccccgtc ttcacagctc ggggctggag     1920

gggcctaggg gagacccacc cggagaccct gcggccccgc gccggcctct ttcccaaccc     1980

ttcggcggcc gcgcgctggc cggggagccg ttggggaggc cctggcggcc gcgcagcagg     2040

tgcaggggcg cagagcctgg gctcgccttg gtacagacga gcgggccccg gccttggcgc     2100

cttcagtttc cttccagttt ttattttcgc tgtgtctaca gagcagatga caccaatttg     2160

gaaacccgcg agagtgggta gagctaagat agtcttgctg tagtagctgt gatattagat     2220

gctcggccat gacttagagg tgtttattta aggactgtga atgactcggt gatttcggaa     2280

aagcttggct tagatgaacg gacatacaca ggggagacag ccctaaggtt tgcagaaaag     2340

gctgattgtg ctgtttgcga agtcgaaata attggtgaaa gtgtagaagg cagaacctct     2400

caggaatgtc tggggaggac aaagaatgtg ttggctgact ttgtttaaac ataaaattgg     2460

gcagacttta attgatttgt gaaatttttt tcaaagtttg tttgaattag cccctatctc     2520

ttctaacatt atcctcttgt gctaattgat tgaccatttt aaataactta gctgttacag     2580

aaagaccgaa aggtgttctt cagtaaaata tattcaagta agttacttaa gtaacgcctt     2640

aaaagataca gaaaagcaaa aaagtattgg cgtattaaaa agaaatcaaa actttccaag     2700

tttaggcctg aacattgcct taaaaatatt taataaggcc tcaaatgacc cagtccgaga     2760

ctgcatgagc ctatttatta ttaaattgta aatattcttc atataaacaa aaatatataa     2820

ccatgtctgt aacaaaaatg gttttgctag cgttgttact ctcttccctt ctccgagggg     2880

tgatttaggc aacttcggag gttgacaatg ccaagcagtc acaatagata gagctttaaa     2940

gcaaattcta tgcatgggtt tggatttatg acaggcccgt caccctgggc ctgtcatagt     3000

accccatgcc agagcaaact gtgtccccga accattgcct ggcctctgtg cccgtaggct     3060

gctggcactg aagtgggttg cacagtggaa aagaagaaag ctctacctgg cagaaatttt     3120

taaaggttaa aataaataat tttaagaaag ctggttcaca aggtgccaca tttgatgaaa     3180

gcaaaataca gtggctttta ttgttactag agtgatgttc ttgcttgttt ttcttttttg     3240

gtgaagttag ccccaaatta ttctcatagc taagcaaata cgagagtgac tgtaaggaca     3300

gttggcattc ccggaattgc taaacttggt aggcaacgct ggtttaagaa tactgagttc     3360

tagccgggcg tggtggctca cgcctgtaat cccaacactt tgggaggctg aggcaggcgg     3420

atcacctgag gtcgggagtt ggagaccagc ctgactaaca tggagaaacg ccatctccac     3480

taaaaatata aaattagcca ggccccgggt gtggtggcac atgccggtaa tcccagctac     3540

tcgggagact gaggcaggag aatcgcttga acccaggagg cggaggttga ggtgagccga     3600

gatcatgcca ttgcactcca gcctgggcaa caagagtaaa actctgtctc aaaaaaaaaa     3660

aaaaaaaaat actgaattct gatcaggtaa cagcaactgt aatacaatgt gataagttga     3720

cttgaagatt acagttttta agaagtatat acccagctaa tacatgaaaa ttaactcgta     3780

aaatctcaaa tgctccagac atttccatga tgcctgttgg tcagtaaaaa tcattctaag     3840

acttagtgga agtaggaaat gtttgtatgg ctgtgtataa aggctataat gtaatcccag     3900

cactttggaa gaccgaggcg ggtggatcac ctggggtcag gagtttgaga cccacctgga     3960

caacgtggtg aaatcctgtc tctactaaaa acacaaaaat tagccgggca tggtggcagg     4020

cgcctgtaat cccagctgct ggggaggctg aggcaggaga atcgcttgaa cccgggaggc     4080

agaggttgca gtgagccaag attgcaccgc tgcactccag cctgggtgac agcgtgagac     4140

tctgtctcaa aaaaaataaa aaagtctata atgctatttt aagtttctaa ggaactgaaa     4200

ctgctctgaa ataaatcaga ccattataag acttttttcc atatcagtga gctaagtgca     4260

gataagcttc tgaaacttgc atgctagatt tttttggtac aaatatttga aatgcttagt     4320

gtgctgcctt ggaaaaacct ggtatttttt gttgtgtcct tatactgcca aggtttatgg     4380

aatcatgtac cttatgccta gtaataatta ggatgaccag gccagtgagt ggttcatatc     4440

cggggcatga ttagctctgc gtgtgctcag ccagtgcccc atcttcaact cgatgtgttc     4500

ctaaggtaga cagcaaattc cctattttat ttctcagatt gtcactgctg ttccaagggc     4560

acacgcagag ggatttggaa ttcctggaga gttgcctttg tgagaagctg gaaatatttc     4620

tttcaattcc atctcttagt tttccatgta agtattcagt ttacatttat gttgcaggtt     4680

aatcttaaga attgtattgc taaggcttct aagtgaattt ctccactcta tttgcatttt     4740

gttgcatttc agaggaacat caagaaatca tgaacaactt tggtaatgaa gagtttgact     4800

gccacttcct cgatgaaggt tttactgcca aggacattct ggaccagaaa attaatgaag     4860

tttcttcttc tgtaagtata tgaggcccat gctggcagtg cagctgagag tgccaggcaa     4920

gtggaaaact ttggcaaggt ctaaggaaga gcaatgaggc ttacatgtct tgttatggaa     4980

tgtagaaatt aattcactgg tggtaaatta atagtgataa tggtgatact catatcagtg     5040

gctagactca aaagagcagg attcattgtg actgatggga atgaaggtcg ctggctattg     5100

gtgtggtgtg tggtgaggct gctagtgagt cacctgtgac cactcttgtt tcaggatgat     5160

aaggatgcct tctatgtggc agacctggga gacattctaa agaaacatct gaggtggtta     5220

aaagctctcc ctcgtgtcac ccccttttat gcagtcaaat gtaatgatag caaagccatc     5280

gtgaagaccc ttgctgctac cgggacagga tttgactgtg ctagcaaggt aagcgatagc     5340

agcaggcctc aaaagcgttg tataaaatgg gcctggtatt ccccacgagg cagatacaag     5400

ttgtgttttt tgggcaataa atgctcacta aaggcaaatg gggcgggggg gtacatgaca     5460

acttcccatg cttttctgtt tattccacgt gttaagccac atatggatag catgacacca     5520

ctcttctttt tcagactgaa atacagttgg tgcagagtct gggggtgcct ccagagagga     5580

ttatctatgc aaatccttgt aaacaagtat ctcaaattaa gtatgctgct aataatggag     5640

tccagatgat gacttttgat agtgaagttg agttgatgaa agttgccaga gcacatccca     5700

aagcaaagtg agttattccc ccatctgagg gcaagatcgg gagcataaga tatgtggatt     5760

cttatcaaac aaacttaaat ttctgattat tatatttcta tactttagta gaaagtagtt     5820

gaaaccccca ttgagtcatg aagcctggga ctcaaactac agaatatatc agcgacagta     5880

tttagaacag gattgttttt attttaattg tggctataag tgaacatcta tcatgagaca     5940

tttgctgcac tttccttgct tgtaggttgg ttttgcggat tgccactgat gattccaaag     6000

cagtctgtcg tctcagtgtg aaattcggtg ccacgctcag aaccagcagg ctccttttgg     6060

aacgggcgaa agagctaaat atcgatgttg ttggtgtcag gtgagatttt ggtgggatag     6120

ctagaggtca agacattgaa cagtttgagt tttacaggct ttctcctagt gtttgctatt     6180

attttaagaa atactaagac acagtgtctc gtctctttat tttaccccag cttccatgta     6240

ggaagcggct gtaccgatcc tgagaccttc gtgcaggcaa tctctgatgc ccgctgtgtt     6300

tttgacatgg gggtgagtat acgtgaccct gttagggaag ggcgggacac aactgacaat     6360

aactagtctt aattctagag ttaacttttt atggcagttg gttctgtatt acatgggttt     6420

cagcctatct gctgcataca tttttgttat tagctgtgga tctggctgac ttattttctt     6480

gattctaggc tgaggttggt ttcagcatgt atctgcttga tattggcggt ggctttcctg     6540

gatctgagga tgtgaaactt aaatttgaag aggtaattta gaacaaaact gtaatactca     6600

gtagccgttc taataaattc ctttttggaa tatttcaaaa tttaagtgtc ttaactaata     6660

ccacaatggg ctgaagtgtc ttggtgtgat attttgagtg atttctttgt gctgtctgac     6720

attacacttg ataccatttg gttttctaaa gtgtgaatca gctttcccag aagtcttgga     6780

taattggtta cattggaaat catggctcac acctgtaatc cagcacttgg ggaggccaag     6840

gtggtaggat cacttgagcc caggagtttg agaccagcct gggcaacaca gtgagacccc     6900

atctctacaa aaaaaatttt aaaattagcc tggtgtggtg gcgggcacct gtaatcccag     6960

ctacttggaa ggctgaggtg ggaggatcac ttgagcccag gaggttgagg ctgcagtgag     7020

ccatgatcat gccactgcac tcagcctggg ctacagagtg agaccctgtc tcaaaaaaaa     7080

aaaagaaaaa gcatgttgct gtgggcttcc tagagaatat gctgactgta gcacatcatc     7140

accccaaatg tgctttgcta gacctatgct tcctctcctt aaaatacttg aaatgtttag     7200

tcacttagga agttaagcca ttatattggt gcttgaattt ataaaataca tccacatggt     7260

ttgttaaaat catgacgtag gcagaatagg atttttatcc tgttggcatg tatttgttaa     7320

aatgttttga catcttgatg ccttcctagg tagtagttag ttgcgtactg ttctttgata     7380

aaaatcatac ccataacatc ctaaaggaga tagggtgcct ggaggggaat gaaaacgagc     7440

cacctgggat atgtagcctg gttttcaggg agatgttgat gtttttttgc ttttgttact     7500

ttaatgataa acctgtctgt tgatgcctgg tctcatgatg tcatgtcaca aggccctgtg     7560

atgttactcc cccatgtgaa tttcccacaa tgaaggctgc tctttctttt ctgtttcact     7620

ctcttagatc accggcgtaa tcaacccagc gttggacaaa tactttccgt cagactctgg     7680

agtgagaatc atagctgagc ccggcagata ctatgttgca tcagctttca cgcttgcagt     7740

taatatcatt gccaagaaaa ttgtattaaa ggaacagacg ggctctgatg gtatgtataa     7800

aggacgaatc acttcatgta taactgaaag ctgatgcaaa aagtcattaa gattgttgat     7860

ctgcctttct agacgaagat gagtcgagtg agcagacctt tatgtattat gtgaatgatg     7920

gcgtctatgg atcatttaat tgcatactct atgaccacgc acatgtaaag ccccttctgc     7980

aaaaggtaat ttctgagcat actgtataaa acaattaaga ggactggtca caacacgtgt     8040

aattaagtag tacttcctct ctccgtctct ttatatagag acctaaacca gatgagaagt     8100

attattcatc cagcatatgg ggaccaacat gtgatggcct cgatcggatt gttgagcgct     8160

gtgacctgcc tgaaatgcat gtgggtgatt ggatgctctt tgaaaacatg ggcgcttaca     8220

ctgttgctgc tgcctctacg ttcaatggct tccagaggcc gacgatctac tatgtgatgt     8280

cagggcctgc gtggtaagta agccatgcat gttgatggtg ctgccaagaa taggcacctt     8340

cttggatgtg tgcttcttgt ctagacgaat aagaaattgt cttgcctaag attaaatata     8400

tatggatatt tttcctaaga aaagttttag aaaagactga tgagtgtatt tctatgtaat     8460

tggaatatat ttaagttcat gccatgtgtc ttgtggtttc cttattacca aaacggtgac     8520

tgaagaaacg cttgctttag aaatacattg aattggccag gtgtgctggc tcacacctga     8580

aatcacaaca cattgggagg ccaaggcaga aggatcactt gagcccagga gttcgagcct     8640

gggcaacata gtgagaccct gtctctacaa aaaattaaaa aattagttgg ccatggtagt     8700

gggcgcctgt agtcccagct gcttggctaa ggtgagaggt ttgcttgagc ctgggaggtt     8760

gaggctgcgg tgagctatga tagcaccatt gtattccagc ctgagtaaca gagaaagacc     8820

ctgtctcaga aaaaaaaaaa atacattgaa ttgtttcctg atgggaagta aatactctca     8880

tgcccagtta ggagtgagtc agggttttta atatgccact ttttctttct caggcaactc     8940

atgcagcaat tccagaaccc cgacttccca cccgaagtag aggaacagga tgccagcacc     9000

ctgcctgtgt cttgtgcctg ggagagtggg atgaaacgcc acagagcagc ctgtgcttcg     9060

gctagtatta atgtgtagat agcactctgg tagctgttaa ctgcaagttt agcttgaatt     9120

aagggatttg gggggaccat gtaacttaat tactgctagt tttgaaatgt ctttgtaaga     9180

gtagggtcgc catgatgcag ccatatggaa gactaggata tgggtcacac ttatctgtgt     9240

tcctatggaa actatttgaa tatttgtttt atatggattt ttattcactc ttcagacacg     9300

ctactcaaga gtgcccctca gctgctgaac aagcatttgt agcttgtaca atggcagaat     9360

gggccaaaag ctt                                                        9373


<210> 2
<211> 461
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Ornithine decarboxylase amino acid sequence

<400> 2
Met Asn Asn Phe Gly Asn Glu Glu Phe Asp Cys His Phe Leu Asp Glu 
1               5                   10                  15      
Gly Phe Thr Ala Lys Asp Ile Leu Asp Gln Lys Ile Asn Glu Val Ser 
            20                  25                  30          
Ser Ser Asp Asp Lys Asp Ala Phe Tyr Val Ala Asp Leu Gly Asp Ile 
        35                  40                  45              
Leu Lys Lys His Leu Arg Trp Leu Lys Ala Leu Pro Arg Val Thr Pro 
    50                  55                  60                  
Phe Tyr Ala Val Lys Cys Asn Asp Ser Lys Ala Ile Val Lys Thr Leu 
65                  70                  75                  80  
Ala Ala Thr Gly Thr Gly Phe Asp Cys Ala Ser Lys Thr Glu Ile Gln 
                85                  90                  95      
Leu Val Gln Ser Leu Gly Val Pro Pro Glu Arg Ile Ile Tyr Ala Asn 
            100                 105                 110         
Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Asn Asn Gly Val 
        115                 120                 125             
Gln Met Met Thr Phe Asp Ser Glu Val Glu Leu Met Lys Val Ala Arg 
    130                 135                 140                 
Ala His Pro Lys Ala Lys Leu Val Leu Arg Ile Ala Thr Asp Asp Ser 
145                 150                 155                 160 
Lys Ala Val Cys Arg Leu Ser Val Lys Phe Gly Ala Thr Leu Arg Thr 
                165                 170                 175     
Ser Arg Leu Leu Leu Glu Arg Ala Lys Glu Leu Asn Ile Asp Val Val 
            180                 185                 190         
Gly Val Ser Phe His Val Gly Ser Gly Cys Thr Asp Pro Glu Thr Phe 
        195                 200                 205             
Val Gln Ala Ile Ser Asp Ala Arg Cys Val Phe Asp Met Gly Ala Glu 
    210                 215                 220                 
Val Gly Phe Ser Met Tyr Leu Leu Asp Ile Gly Gly Gly Phe Pro Gly 
225                 230                 235                 240 
Ser Glu Asp Val Lys Leu Lys Phe Glu Glu Ile Thr Gly Val Ile Asn 
                245                 250                 255     
Pro Ala Leu Asp Lys Tyr Phe Pro Ser Asp Ser Gly Val Arg Ile Ile 
            260                 265                 270         
Ala Glu Pro Gly Arg Tyr Tyr Val Ala Ser Ala Phe Thr Leu Ala Val 
        275                 280                 285             
Asn Ile Ile Ala Lys Lys Ile Val Leu Lys Glu Gln Thr Gly Ser Asp 
    290                 295                 300                 
Asp Glu Asp Glu Ser Ser Glu Gln Thr Phe Met Tyr Tyr Val Asn Asp 
305                 310                 315                 320 
Gly Val Tyr Gly Ser Phe Asn Cys Ile Leu Tyr Asp His Ala His Val 
                325                 330                 335     
Lys Pro Leu Leu Gln Lys Arg Pro Lys Pro Asp Glu Lys Tyr Tyr Ser 
            340                 345                 350         
Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg Ile Val Glu 
        355                 360                 365             
Arg Cys Asp Leu Pro Glu Met His Val Gly Asp Trp Met Leu Phe Glu 
    370                 375                 380                 
Asn Met Gly Ala Tyr Thr Val Ala Ala Ala Ser Thr Phe Asn Gly Phe 
385                 390                 395                 400 
Gln Arg Pro Thr Ile Tyr Tyr Val Met Ser Gly Pro Ala Trp Gln Leu 
                405                 410                 415     
Met Gln Gln Phe Gln Asn Pro Asp Phe Pro Pro Glu Val Glu Glu Gln 
            420                 425                 430         
Asp Ala Ser Thr Leu Pro Val Ser Cys Ala Trp Glu Ser Gly Met Lys 
        435                 440                 445             
Arg His Arg Ala Ala Cys Ala Ser Ala Ser Ile Asn Val 
    450                 455                 460     

<210> 3
<211> 7623
<212> DNA
<213> Homo sapiens

<220> 
<223> Human spermidine synthase full nucleotide sequence

<400> 3
ctgcaggcgc gcactaccat gcccagctaa tttttgtatt tttagtacag acggggtttc       60

accatgttgg ccaggatcgt cttgatctct tgacctcgtg atccgcccgc ctccgcctcc      120

gcctcccaca gtgctgggat taccggggtg aaccatcacg cccaggcacc tagcaattct      180

ttagcggtct tggtttacct cccctttaga aggagcttaa aagcaagcaa ggcacattgt      240

tgcctaggct tgaggcttgc tctcacccat aaacaacgct gttactctgc tctggggacg      300

acacaggaaa cgttccccac ctccaggtgg aggctgcaaa acgtgtcaaa accatccctg      360

acataatgtc aagagtagct tatactagtt tcatcttcct tccttggcat tcgaactgcg      420

tgtggaacaa ttagcattta atatttggta attagcatgc ttaatgtgat tctgagaagt      480

tctttgacat tctcataaaa acagcacatt cccacccacc cttcaaagag caagacccag      540

tttgtcaaga aaaattgcgt gccagtcttt tctggtgctg aatatgtatg ttctgggcct      600

cttcctggac actgctggta aatttagaaa ctcgtttaga aaagcacttc tctcgtattc      660

aacagcctat aggctcatgg cgcagaatct aagggaaaat ggctaaatcc agcttgttaa      720

ttcgcgggct gtgatgattc tttccaagta aataaaaacc ctcggttcgc cccgacgagc      780

cacataatct gttcaaatcc aacaaggaac cagattttgg acgcaaagaa ggatacgttc      840

tactcgcccc gtgcaacaac gtaaaccact gtagccgccc gctcccgtgt ctccagccca      900

aaggctgact ctccagtccg cacgtcgcag cgctcttgcc ctccacacca agcccgagtc      960

ccgcagcccc tcgaggccct cggtgcctcc caaccccgag aaggaagcgg gggccggtgg     1020

tgcaccgccc cggctgcttg gggcggagga aggacccgga ccccttccgc cggcccagcc     1080

cgccccggaa cccgacccgg ccgcccggcc ccggccgggc cccacgtggc ccctggagcg     1140

ggccgcacta ccctgctgcc gccgacggac ggcgcgccac agccactctg cgccgctctg     1200

cgagccggtg gccaatgagc gccaggcgag gccgctttgc cattggcgag cgcgggctcc     1260

gcccccgccg gcaggccccg ccccgcgccc gggttaggtt gcggcgcggg cggcgggcgg     1320

agctggtccc gttgtgctgc ggcgccgcgc ggcctgcagt cccgggcccg cgccccgcgc     1380

cgcccgcccg cccgccatgg agcccggccc cgacggcccc gccgcctccg gccccgccgc     1440

catccgcgag ggctggttcc gcgagacctg cagcctgtgg cccggccagg ccctgtcgct     1500

gcaggtggag cagctgctcc accaccggcg ctcgcgctac caggacatcc tcgtcttccg     1560

caggtaccgc cgctgcccgc aggcgcctgc cccctaggct cagcccgggc cgcctgctgc     1620

ccgcctcacg ggcctctcca cgccgggacc caagcgggct ggacctcgtc ctgccctggc     1680

cccctcgcca cccctcacac cgcctccctg ggctggggct gggactgcgg gctggcctct     1740

tgggtggggg agtcggagtc tgcgccccgc tccacgtgtc agccctcagg acacgtcaga     1800

gcccgaggag accccgggtc ccaccccggc ctccacccgg cggcccgcct gccgttcctc     1860

gccacgtgtc accatcgctc ctcatccctg ggacccctag gcgggatggg gagaccctcc     1920

tcacccaggg cggcttgggg tacgttttcc ccaccccaga gaacccaggt ccccgactgt     1980

cactccgccc gcagtaagac ctatggcaac gtgctggtgt tggacggtgt catccagtgc     2040

acggagagag acgagttctc ctaccaggag atgatcgcca acctgcctct ctgcagccac     2100

cccaacccgc gaaaggtacc ccagtgtccc ctggaacagt gccggacgag gggcggcccc     2160

aggtgtgctc cgggctcttc ccagatgctg cctgcatggt tgtcagagaa agtgctagca     2220

aggccagggg cgtcccgcgg aggggtgggg gccgacactg acgcggcctc ggaatcctag     2280

ggcagccctg gaaggaactt ccaggaaagg ggacaccggc acgaaagcgt ttccgagggt     2340

agaaaaagat gaggcccgtg ggtccgaggg gtcagggggt ctgcttcagg ggcctggggg     2400

ctcccagtcc tgccagggcc cctgccttga ctgccccctc ctcccaggtg ctgatcatcg     2460

ggggcggaga tggaggtgtc ctgcgggagg tggtgaagca cccctccgtg gagtccgtgg     2520

tccagtgtga gatcgacgag gtgagtgccg gcgtagagcc aggtttgagt cctggttctc     2580

ccagcggcca gctgtgccct gaaatggctg cacacccccg agcaaggcag gtagggcctg     2640

tttctccatc tggaaaacac ctggtcgggg agggttcagt aggaaaacca gatggcagag     2700

ggcctggcag gtggtgaggg cacctgcgtg gcgagctctt actaaaactg agctgatttt     2760

tttttttttt tttttttgag acagagtttc gctcttgttg cccaggctgg agtgtgatgg     2820

tgcgatctcg gctcactgca acctccacct cctgggctca agtagttctt ctgcctcagc     2880

ctccggagta gctgggatta cagacatgcg ctaccatgcc cggctaattt tgtattttta     2940

gtagagacag ggtttctcca tgttggtcag gctggtctcg gacctggcga ccacaggtga     3000

tccgccagcc tcgtcctccc aaagtactgg gattacaggc gtgagccacc acgcccagcc     3060

gactaagctg atttttaatc tgagccccag gcagggcccc aagacagctc aactatttgt     3120

acgttacccc ttacactcag tagctgctca ctaaaatcat gctacgtgcc aggtgttgcc     3180

cgggtatggg gacagtggta gacgacagat cagtccctgc cctctaggag ctgatgtcgt     3240

agttaaagga gacatcagat ggccagacgt ggtggctcac acctgtaatc ccagcacttt     3300

gggacgccaa ggcgggcaga tcacctgagg tcaggagttc aagagcagcc tggccaacct     3360

ggtgaaaccc catttctact aaaaatacaa aaattagccg ggcatggtag tgcatgtctg     3420

taaacccagc tactagggag gctgaggtgg aagaattact tgagcccggg aggcggaagt     3480

tgcaatgaac cgagatctcg ccactgcact ccagcctggg tgacagagga agaatctgtc     3540

tcaaaaaaaa caaacaacaa aaatagagac atcaaaggat ggtctgatga aggcaagaca     3600

ggggctgggg gacaggagaa ggcagggttc ctgtgaatgc atggggggtg gtcagggcag     3660

gcctccagga ggtggcgttt gagctgagac ctcagtgaaa agcaggtggc cgtgtgcagg     3720

gagggggagg ttctcctggc cagaggttgg aattgcatcc ttctaaaata ggaaacaggc     3780

caagcgctgg tggctcacac ctgtaatctc agcactctgg gaggctgagg cgggcagatc     3840

acaaggtctc tactaaaaat acaaaaaaaa aaaaaaatgg cccagcttgg tggcgtgtgc     3900

ctgtaatccc aactactcgg gaggctgagg caggagggtg cagtgagctg agatcgtgcc     3960

actgcactcc agcctgggca gcagagcaag actgtctcga aaaataaata aataaaatag     4020

gaagcgacaa gaaagccact cagatggggc gatttggtct ggaaggaggg ggtagggatg     4080

ggagagagga gcccaagccg ccggcaggag ccagctctca aggagaaatg gaggtaccag     4140

agttctcccc gctttacaca ttataaactg aggttcccaa aaggggccag gtgtggtggc     4200

tcacagctgt aatcctagca cttttggagg ccgaggtggg aggatcgagg agttcgaggc     4260

aacataggga gactctatct ctaccaaaaa tttaaaaagt agccaagtat gattgaacac     4320

acttgtccca gctactcagg aggctgatgg gggaggatca cctgagcccc ggaggccgag     4380

ggtgtagtga gccatgatcg atgccactgc actccagcct gggccacaaa gtgagaccct     4440

gtctcaaaaa aaaataataa aaaaaaggga aggggttggc caaggcggct tgcctgtgag     4500

gcacttggag agtcccacgt ggctgtgctg gctccaggtc ccccagcccc ttggcccaga     4560

ctggtccctc ccatcccctc caggatgtca tccaagtctc caagaagttc ctgccaggca     4620

tggccattgg ctactctagc tcgaagctga ccctacatgt gggtgacggt tttgagttca     4680

tgaaacagaa tcaggatgcc ttcgacgtga tcatcactga ctcctcagac cccatgggta     4740

agcagtggat gggccccagg gttttctggc agctgcaggt ctggaggtca gcctccccca     4800

ggccttcaga gtaaaggata gagcggcctc ccaccccccg aactagagct gtacttttcc     4860

cttctcattt gttacctgcc ctctgaaaca tggctcagga cagtaggcag gagccaggcg     4920

actgcccaga ttcacaagct ggtgaccaag gagagtgggg atctggcatt gggacactga     4980

ggaccctgtg tcctcttcag cctcccctct gctctgaagt ggtcagcact ggagtggggg     5040

caggttctag tcttgaacga aggcctaggt tagaggttcc tctgctgtgg tgccaatgag     5100

actcccccaa gaatgggatt caggtgtgga tcccccacag acctgggttc agatcctggc     5160

tctggccacc tggtagctgt gtgggtgaca gtggccctgg aggtcacagc cagactgttc     5220

agtgtgtctc cctctgtctt ccccaggccc cgccgaaagt ctcttcaagg agtcctatta     5280

ccagctcatg aagacagccc tcaaggaaga tggtgtcctc tgctgccagg gtgagccaca     5340

ggcctggagc actggggcgg ggcggggtgg ggcagggcag gccctgccgg atgctgatgc     5400

ttaggggccc ccaggcgagt gccagtggct gcacctggac ctcatcaagg agatgcggca     5460

gttctgccag tccctgttcc ccgtggtggc ctatgcctac tgcaccatcc ccacctaccc     5520

cagcggccag atcggcttca tgctgtgcag caagaacccg gtgagatggg ggtgtctggg     5580

ggtgggggtt ggggggaagg tgggcataaa tagagatccc tgcccctgcc gggcgcggtg     5640

gctcacacct gtaacccagc actttgggag gctgaggcgg gcagatcaca aggtcaggag     5700

atcgagacca tcttggctaa cacggtgaaa ccccgtctct actaaaaata caaaaaaatt     5760

agccaggcat ggcagcgcgc gcctgtagtc ccagctgctg gggaggctga ggcaggagaa     5820

tggcgtgaac ccgggaggcg gagcttgcag tgagccgaga ttgcgccact acattccagc     5880

ctgggtaaca gaggaagatt ccgactcaaa aaaaaaaaaa aaaccctccc caggccaggt     5940

gcggtgtctc atgcctgtaa ttccagcatt ttgggagacc aaggtgggcg gatcacttga     6000

ggtcaggagt acaagaccag cctgaccaac atggagaaac cccatcacta ctcaaaatac     6060

aaaaaaaaaa aaaattagcc gggcgtggtg gcgcgtacct gaggctgagg caggagaatc     6120

acttgaacct gggagacaga ggttgcagtg agctgagatg acgccactgc actccagcgt     6180

ggcaacagtg agactccgtc tcaaaaaaaa aaaaaaaagt gccccccctg atgtgcccct     6240

ggcccggtcc ccagagcacg aacttccagg agccggtgca gccgctgaca cagcagcagg     6300

tggcgcagat gcagctgaag tactacaact ccgacgtgca ccgcgccgcc tttgtgctgc     6360

ccgagtttgc ccgcaaggtg ggtggcctgc ggggctgggt ggtgggaccc agggacccag     6420

agcgccctcc tgactggcct catgtccctc caggcactga atgatgtgag ctgagcccag     6480

gcgccaccac tgatgccacc caggacctcg gaccttggag cctgcggggt gcctcggccc     6540

ctccagcccc gggccggacc tcctgctggc tctcgcccac caaccaagtg ttacaagccc     6600

cagaatgctg cccggcctgc cctgctgggc ggactgtctg tgtgtctgtc tctctggcgt     6660

tccacctcca agcctatacc agctgtgtac agcgccatct ctctgccttc tgttgcccct     6720

cactcaccaa acacgtgtat ttatagcaaa gattggagtc ctgtgtctcc tgaccttggc     6780

tgggcccagg cagggccaca ttcaccattg ggtgcctctg gggtgagggt ctgcagaggc     6840

cttgctggct gacccccaag tgtctgctgc agggctgagg ctgcaggcgg gccatcgtgg     6900

atagcctggg gcacagaggg tcaccgcagt cgtcacgtgg gacccagagc tgtcctggga     6960

agctgactta gctgtccttt taccaagccc ttcacaaggc cactggtgac agccccccag     7020

ggcagtgggg tgggtgagat cagggtgggg ctgcccggga gcattctcag aaaaattggg     7080

gacactcaca ggtgtaagtc aggtcccatc caggtactcc agggcaaata caggaagggg     7140

tggcggggct ggttaccttc ggccttttta agcacatcag gagcttaaca ctggcccagt     7200

gactgtgccc tgactccacc cggcattcag acttgggttc aaattcccac catgccccgc     7260

cccctatgtg gacaaattga gaaagcaagt gtgggcaccc caccagggac tgcgaggacc     7320

agggctgtcc cctctccaag gtgctgaact cccgccttcc aggacccaac ggtggtggga     7380

ggacaggaaa ggaaccctct ttgcatgggc ctgagttgcc aacccctttc cccaccctgg     7440

gcaggggctg ggctagcgga cgcatcaggg agggaggccc cactcccagc cgaggcagcc     7500

accttggagc cctaactcac ccgggtatgt tttctgggac accagtgtaa gggggattca     7560

gtttcgccat caactctggc ttcaggccag tcatagccct ccagtctcca cctgcccccc     7620

act                                                                   7623


<210> 4
<211> 302
<212> PRT
<213> Homo sapiens

<220> 
<223> Human spermidine synthase amino acid sequence

<400> 4
Met Glu Pro Gly Pro Asp Gly Pro Ala Ala Ser Gly Pro Ala Ala Ile 
1               5                   10                  15      
Arg Glu Gly Trp Phe Arg Glu Thr Cys Ser Leu Trp Pro Gly Gln Ala 
            20                  25                  30          
Leu Ser Leu Gln Val Glu Gln Leu Leu His His Arg Arg Ser Arg Tyr 
        35                  40                  45              
Gln Asp Ile Leu Val Phe Arg Ser Lys Thr Tyr Gly Asn Val Leu Val 
    50                  55                  60                  
Leu Asp Gly Val Ile Gln Cys Thr Glu Arg Asp Glu Phe Ser Tyr Gln 
65                  70                  75                  80  
Glu Met Ile Ala Asn Leu Pro Leu Cys Ser His Pro Asn Pro Arg Lys 
                85                  90                  95      
Val Leu Ile Ile Gly Gly Gly Asp Gly Gly Val Leu Arg Glu Val Val 
            100                 105                 110         
Lys His Pro Ser Val Glu Ser Val Val Gln Cys Glu Ile Asp Glu Asp 
        115                 120                 125             
Val Ile Gln Val Ser Lys Lys Phe Leu Pro Gly Met Ala Ile Gly Tyr 
    130                 135                 140                 
Ser Ser Ser Lys Leu Thr Leu His Val Gly Asp Gly Phe Glu Phe Met 
145                 150                 155                 160 
Lys Gln Asn Gln Asp Ala Phe Asp Val Ile Ile Thr Asp Ser Ser Asp 
                165                 170                 175     
Pro Met Gly Pro Ala Glu Ser Leu Phe Lys Glu Ser Tyr Tyr Gln Leu 
            180                 185                 190         
Met Lys Thr Ala Leu Lys Glu Asp Gly Val Leu Cys Cys Gln Gly Glu 
        195                 200                 205             
Cys Gln Trp Leu His Leu Asp Leu Ile Lys Glu Met Arg Gln Phe Cys 
    210                 215                 220                 
Gln Ser Leu Phe Pro Val Val Ala Tyr Ala Tyr Cys Thr Ile Pro Thr 
225                 230                 235                 240 
Tyr Pro Ser Gly Gln Ile Gly Phe Met Leu Cys Ser Lys Asn Pro Ser 
                245                 250                 255     
Thr Asn Phe Gln Glu Pro Val Gln Pro Leu Thr Gln Gln Gln Val Ala 
            260                 265                 270         
Gln Met Gln Leu Lys Tyr Tyr Asn Ser Asp Val His Arg Ala Ala Phe 
        275                 280                 285             
Val Leu Pro Glu Phe Ala Arg Lys Ala Leu Asn Asp Val Ser 
    290                 295                 300         

<210> 5
<211> 1612
<212> DNA
<213> Homo sapiens

<220> 
<223> Human Spermine synthase nucleotide mRNA nucleotide sequence

<400> 5
tagtgaggcg aggccctgtg ccatgcctgg ggcagcagca cggcacagca cgctcgactt      60

catgctcggc gccaaagctg atggtgagac cattctaaaa ggcctccagt ccattttcca     120

ggagcagggg atggcggagt cggtgcacac ctggcaggac catggctatt tagcaaccta     180

cacaaacaag aacggcagct ttgccaattt gagaatttac ccacatggat tggtgttgct     240

ggaccttcag agttatgatg gtgatgcgca aggcaaagaa gagatcgaca gtattttgaa     300

caaagtagag gaaagaatga aagaattgag tcaggacagt actgggcggg tgaaacgatt     360

accacccata gtgcgaggag gagccatcga cagatactgg cccaccgccg acgggcgcct     420

ggttgaatat gacatagatg aagtggtata tgacgaagat tcaccttatc aaaatataaa     480

aattctacac tcgaagcagt ttggaaatat tctcatcctt agtggggatg ttaatttggc     540

agagagtgat ttggcatata cccgggccat catgggcagt ggcaaagaag attacactgg     600

caaagatgta ctcattctgg gaggtggaga cggaggcata ttgtgtgaaa tagtcaaact     660

aaaaccaaag atggtcacta tggtagagat tgaccaaatg gtgattgatg ggtgtaagaa     720

atacatgcga aaaacgtgtg gcgatgtctt agacaatctt aaaggagact gctatcaggt     780

tctaatagaa gactgtatcc cggtactgaa gaggtacgcc aaagaaggga gagaatttga     840

ttatgtgatt aatgatttga cagctgttcc aatctccacg tctccagaag aagattccac     900

atgggagttt ctcagactga ttcttgacct ctcaatgaaa gtgttgaaac aggatgggaa     960

atattttaca caggggaact gtgtcaatct gacagaagca ctgtcgctct atgaagaaca    1020

gctggggcgc ctgtattgtc ctgtggaatt ttcaaaggag atcgtctgtg tcccttcata    1080

cttggaattg tgggtatttt acactgtttg gaagaaagct aaaccctgaa gatcagtagc    1140

ccctaatcac atgtgctgca aatagccttc ctgacctcca tatgctgtac atgacatcaa    1200

aatgagtcag gcaattgatt gtgaattcct taaagttttc ctttttttaa taattatttt    1260

taatttaaaa aagcaaatgg aaaatgtata ttttgatgag cttagggtgt tttttttttg    1320

aaagtcagct gaaggatggt tagacagcac agcgaagact gctaaatgca ctgacccccc    1380

ccattagaat gtgatttttg ttccttttta tttctctgtg ggcttttgtt tttgtttttg    1440

ttttggtaga tcttcaattt ggatatttgg aggagtgaac atcgttgttt tgctggaggg    1500

aagatcttga tggtgtttct ttccccaaaa attgacttag atattaaaat ttggtgctta    1560

taagagagag ttaaaaaaaa ataggattgc ttcaattaaa attacaaaag ag            1612


<210> 6
<211> 366
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Spermine synthase amino acid sequence

<400> 6
Met Ala Ala Ala Arg His Ser Thr Leu Asp Phe Met Leu Gly Ala Lys 
1               5                   10                  15      
Ala Asp Gly Glu Thr Ile Leu Lys Gly Leu Gln Ser Ile Phe Gln Glu 
            20                  25                  30          
Gln Gly Met Ala Glu Ser Val His Thr Trp Gln Asp His Gly Tyr Leu 
        35                  40                  45              
Ala Thr Tyr Thr Asn Lys Asn Gly Ser Phe Ala Asn Leu Arg Ile Tyr 
    50                  55                  60                  
Pro His Gly Leu Val Leu Leu Asp Leu Gln Ser Tyr Asp Gly Asp Ala 
65                  70                  75                  80  
Gln Gly Lys Glu Glu Ile Asp Ser Ile Leu Asn Lys Val Glu Glu Arg 
                85                  90                  95      
Met Lys Glu Leu Ser Gln Asp Ser Thr Gly Arg Val Lys Arg Leu Pro 
            100                 105                 110         
Pro Ile Val Arg Gly Gly Ala Ile Asp Arg Tyr Trp Pro Thr Ala Asp 
        115                 120                 125             
Gly Arg Leu Val Glu Tyr Asp Ile Asp Glu Val Val Tyr Asp Glu Asp 
    130                 135                 140                 
Ser Pro Tyr Gln Asn Ile Lys Ile Leu His Ser Lys Gln Phe Gly Asn 
145                 150                 155                 160 
Ile Leu Ile Leu Ser Gly Asp Val Asn Leu Ala Glu Ser Asp Leu Ala 
                165                 170                 175     
Tyr Thr Arg Ala Ile Met Gly Ser Gly Lys Glu Asp Tyr Thr Gly Lys 
            180                 185                 190         
Asp Val Leu Ile Leu Gly Gly Gly Asp Gly Gly Ile Leu Cys Glu Ile 
        195                 200                 205             
Val Lys Leu Lys Pro Lys Met Val Thr Met Val Glu Ile Asp Gln Met 
    210                 215                 220                 
Val Ile Asp Gly Cys Lys Lys Tyr Met Arg Lys Thr Cys Gly Asp Val 
225                 230                 235                 240 
Leu Asp Asn Leu Lys Gly Asp Cys Tyr Gln Val Leu Ile Glu Asp Cys 
                245                 250                 255     
Ile Pro Val Leu Lys Arg Tyr Ala Lys Glu Gly Arg Glu Phe Asp Tyr 
            260                 265                 270         
Val Ile Asn Asp Leu Thr Ala Val Pro Ile Ser Thr Ser Pro Glu Glu 
        275                 280                 285             
Asp Ser Thr Trp Glu Phe Leu Arg Leu Ile Leu Asp Leu Ser Met Lys 
    290                 295                 300                 
Val Leu Lys Gln Asp Gly Lys Tyr Phe Thr Gln Gly Asn Cys Val Asn 
305                 310                 315                 320 
Leu Thr Glu Ala Leu Ser Leu Tyr Glu Glu Gln Leu Gly Arg Leu Tyr 
                325                 330                 335     
Cys Pro Val Glu Phe Ser Lys Glu Ile Val Cys Val Pro Ser Tyr Leu 
            340                 345                 350         
Glu Leu Trp Val Phe Tyr Thr Val Trp Lys Lys Ala Lys Pro 
        355                 360                 365     

<210> 7
<211> 5160
<212> DNA
<213> Homo sapiens

<220> 
<223> Human deoxyhypusine hydroxylase full nucleotide sequence

<400> 7
gcttagcagg ggagagagac actggcaggg tgactaaccc atcattccag gcaggaagta       60

agccagcagg ggtggctgac ttgtgagtga ccgggggact ggagggctgg ggagggcctc      120

agggaggagg tgatgtggag gcagagacct aagccagctt agggagggaa tcaggtggag      180

acccggggat ggggaagcag cggtggaaag gccctgaggc aggaccctgc gggaggggtg      240

agggccaaag gaacatgtgc ggccccacct gaccaggtaa ggcctgcggg ccactgtaag      300

ggcttgggat tttgtcctaa aggtgatgag atatcgtgag agctttaagc atggaacaga      360

acagcagaat tgagtgtcac acgtaccccc ggctgccccg gaggaggaga gactgagggt      420

cggggtggga tgtggacaag aagtggcagg ggagaaagga acatgcatgt ccgtggcggc      480

ataactcata acagctaaaa agcagagaca attcaagcat ccagccacag tgagtggaca      540

cagcatgggc cgtccacacc acggaacgtg actcagccac aaaaaggaat gacgggccgg      600

ccgaagcggc tcatgcccct aatcccagca gttagggaga ccaaggcagg aggatcgctt      660

gagcccagga gttcaacacc agcctgggcg acagagcggg acttcatctc tataaagaaa      720

aaactaataa aataaaaatt tgtttcattt ttgggccagg cgcggtggct cacgcctgta      780

atcccagcac tttggaggcc aaggcgggtg gatcacgagg tcaggagatc gagaccatcc      840

tggctaacat ggtgaaaccc cgtctctact aaaaatacga aaagatttgc tgagcgtggt      900

ggcaggcgcc tgtagtccca gctactctgg aggctgaggc aggagaatag catgaacctg      960

ggaagcagag cttgcagtga gccgagatcg cgcccactgc actccagcct gggcgacaga     1020

gcgagacacc gtctcaaaaa aaaaaaagaa gaaatgttgg aaggtagcag gagatctctg     1080

aagaggtctg gtgggccagg acaaggtatc agaggtagag ggcactgggt gggttcagag     1140

gggtcttggc agagggactg gacgtggggg ttcagagaaa gggggtcagg ccggctcagg     1200

ggctcaaggc ccgggatgga agcgggtgag caaagctggt tgtcgccgtt ttgccaaatg     1260

gggcgcagca agtgtctgtc cagattgtcg ccctcgcctt cctcatccct ggggcatcct     1320

tggccaagtg gtcgccctgg caaccagaga tggggagggt ctgaggctgc tccaggtcag     1380

ggctggggca gggctgggca gggcttccca gggacccgag actggcaggg agacaagcag     1440

gggcctggtt acctcgatga cggggtccga ggaatactgc ttcaggatct ccagaacttc     1500

cgggtccccg atggccccca gggcctcccc tgggaagaag cagccggaga gctcatgttg     1560

gtggggtgga tgtgtggaaa atgcccggct acctctggga ccggaggaca cccctcccag     1620

ggctctgcca ctgtggggaa gccccgcctc tgtccacggc tgattggagc agcagtcggt     1680

acaggctccc cgctggacca atcagcatcc cctccccaga gcaaggcact gcctggaacc     1740

gcacctggct gccgctcaga gcaaaatgga ccccatcccg gcccgtacca tgagacaggg     1800

agacaagtat atccctacaa ctcgggatca cagctgacaa gcagctccaa gaacccagga     1860

ggtcgggggt gcagtgagct atgatcacac cactgtactc cagcatgggc gacagagtga     1920

gaccctgtct caaaaaaaca aacaaaaaaa attcccaaaa caggccgggc ctgccggctg     1980

gagactccag aatttggggc cactggggct acacttaggt gggttcgggt acaggcgcaa     2040

gtgcaggcgt cgcaagccca ggtcggagca aggctggcgg cggctccccg tagagccctg     2100

ggtgcagatg ttccttgaat tttctcagaa tcgagctcaa gggccctgcc tgtgaggcag     2160

ctgagctggt ggcttttgcc tttcctgaag gttgcggttt gcgtttgtgc acctgcctgg     2220

caggctccct ctgccgggaa aagtcccgta tgcgccaaca caggctctgt gtcaggcacc     2280

tcccacgcgc taattgcaaa tgagctcact ggttacagaa acacagtccc agtggcacag     2340

acgcaccaac tacctgcctc actggtctcc ttcgctgtct aggtccctcg ctacaacagt     2400

ccattttttt ttttttttta gagcttcgct cttgtgaccc aggctagagt acaatggcgc     2460

gatctccact cactgaaaac tccgcctcct gggttcaagt gattctcctg cctcagcctc     2520

ccaaagtagc tgggattaca ggcgccggcc accacgccca gctacttttt tttgtatttt     2580

tagttgagac ggggtttcac catgttggcc aggctagtct tgaactcctg acctcaggtg     2640

atccacccgc ctcagcctcc caaagtgctg ggattacagg cgtgagccaa tgcacccgac     2700

ctgaacagtc catttttttg agacagggtc tcactctgtt gcccaagctg gagtgcagtg     2760

gcatgatcat ggctaactgc agcctcaacc tccctggctc aagtaatcct cctgcctcag     2820

cctcctgagt agttgggacc acacgcgtga gccacgatgc ccggcttgta tctgtattgt     2880

cactgttttg tctcttacta catgacagag cctggcatac agtaggtgct cactaaatgt     2940

gtgtccaatg agtggagtaa atctaatata cattagggat tggggatcta tggcttgtcg     3000

cttgttttta tacgagcaaa gaatggtttt taaaacactt ttaagggttt aaggcggggt     3060

gcgatggctc atgcctgtaa tcccagcact ttgggaggcc gaggcaggtg gatcacttga     3120

ggccaggagt tcaaggccag cctggccaac atggcaaaac ccatctctac taaaaataca     3180

aaaattaccc aggcgtggtg gcacacacct gtaacgctat ctacttggga ggctaaggca     3240

ggagaatcac ttgaacccgg gaggcagagg ttgcagtgag ccaagacggc accacagtac     3300

cccagcctgg gcgacagagt gagactctga ctcaaaacaa acaaataaat ggtttaaaac     3360

aaaaaatcaa agggatagta cttcctgatg ggtggaattt atatgaaatt caaatctcag     3420

catttacaaa tgaagtttgt tttttgtttt ttcacagaca ggatctcact ctgttgccca     3480

ggctggagtg cggtggcacg atcatggctc actgcaacct tgacttcccg ggctccagcg     3540

attctcccgc ctcagcctcc caagtggctg cgactacagg tgcatgccac catgcctggc     3600

taatttttgt attttttcta gagacagggt tttgccatgt tgcccaggat ggtcttgaac     3660

tcctgagttc aaacgatcca ccttcctggg cctcccaaag tgctaagatt acaggcctga     3720

gccaccgccc cctgcccagt tgaggttgtc tgggcacaca gccttagcca tttggtgaca     3780

gatgacctgc gctggcttta ttgagtcgct gtctggctgc agagctgcag gtatttacta     3840

tctggtgctc tatggggcag ttgaccactc tgatatttat cacctgagtg aggaagggga     3900

cacgtggggt catgaagaag tgaggcagga gggagcaggt gcccgggaca cagacaggtg     3960

ctcacctgcc tcatggcgca ccatgggctc ctgacgggtg tcttgcagca cgtccaccag     4020

catggggatg gcgcgggcat cctgcatctg gcccaggcag taggccagct cgtgcttgag     4080

cagggcggaa tcgtcatcga aggcctggct gatccatgca atggcgcctg ggccgccgag     4140

cccacgcagc gtgaacagcg cccggaagcg ggcctgcagg ggctgcttgg ggtccaccag     4200

cgtctgcccg atggcatcca cctcctgctc cgtcaccatc gtgctgtcaa tgggtcccgg     4260

ccttccacaa ccctgctcag gctaaacctg gggacgcggg gatgtaagaa cctgtggcag     4320

aaaaatgaga gcccaggtta gaagccccct tcaccagtgc gttgtctgtt cctaggacct     4380

gggtggggca aattcctacc cactgaccaa cctgagcatc tacgctgaaa gctcagctcc     4440

aacctcccta ctagctgtgc agccttccgt aagttgcttt ccctctctgg gcctcagtct     4500

ctgcactgcc tctcgcctat aggcctatca gaaatgacct ccactgtctg ctctccacac     4560

agcagccaga gggacagctg acccccaaaa tggccctagc gatccccacc caatattcaa     4620

ggctttatat agcgatcccc acccaatatt caaggcttta tatagtcctc tcccactctg     4680

aacagggctg acccatgtga atgccaagaa gatggaacag agcaagactt ccaaggttag     4740

ggcataaaaa gcacaacagt ctcatccttg ttctctctct aggggaagcc agtgaccatg     4800

ttgtgaggat gctcaagcag tcttttgtag gggcccacgt ggcaaaaaac tgagccctcc     4860

caccaacagc catgtgagag aagtgggctg gcagcagctc gtccagcccc aagcgaacct     4920

tcagatgatg cagccccaga gcgtctccac tgaggcctta ccagaggcca gacccagagc     4980

cagccagcta agccaggccc agagcaactg tgtgcgacac tgtttactgt tgttgaaggt     5040

aaccaagtat gtttttttgt ttgtttttga gacaggatct tgttctgtcg ccaggctgga     5100

gtacggcagc atgatcacgg ctcactgtag cctcgaactc ccagtctcaa gtgatcctcc     5160


<210> 8
<211> 302
<212> PRT
<213> Homo sapiens

<220> 
<223> Human deoxyhypusine hydroxylase amino acid sequence

<400> 8
Met Val Thr Glu Gln Glu Val Asp Ala Ile Gly Gln Thr Leu Val Asp 
1               5                   10                  15      
Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          
Gly Leu Gly Gly Pro Gly Ala Ile Ala Trp Ile Ser Gln Ala Phe Asp 
        35                  40                  45              
Asp Asp Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  
Met Gln Asp Ala Arg Ala Ile Pro Met Leu Val Asp Val Leu Gln Asp 
65                  70                  75                  80  
Thr Arg Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      
Ala Ile Gly Asp Pro Glu Val Leu Glu Ile Leu Lys Gln Tyr Ser Ser 
            100                 105                 110         
Asp Pro Val Ile Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             
Leu Glu Trp Leu Gln Gln His Gly Gly Glu Pro Ala Ala Gly Pro Tyr 
    130                 135                 140                 
Leu Ser Val Asp Pro Ala Pro Pro Ala Glu Glu Arg Asp Val Gly Arg 
145                 150                 155                 160 
Leu Arg Glu Ala Leu Leu Asp Glu Ser Arg Pro Leu Phe Glu Arg Tyr 
                165                 170                 175     
Arg Ala Met Phe Ala Leu Arg Asn Ala Gly Gly Glu Glu Ala Ala Leu 
            180                 185                 190         
Ala Leu Ala Glu Gly Leu His Cys Gly Ser Ala Leu Phe Arg His Glu 
        195                 200                 205             
Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro Gln 
    210                 215                 220                 
Leu Ala Ala Ala Leu Ala Arg Cys Thr Glu Asn Pro Met Val Arg His 
225                 230                 235                 240 
Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu Ala 
                245                 250                 255     
Ala Leu Gln Ala His Ala Asp Asp Pro Glu Arg Val Val Arg Glu Ser 
            260                 265                 270         
Cys Glu Val Ala Leu Asp Met Tyr Glu His Glu Thr Gly Arg Ala Phe 
        275                 280                 285             
Gln Tyr Ala Asp Gly Leu Glu Gln Leu Arg Gly Ala Pro Ser 
    290                 295                 300         

<210> 9
<211> 1267
<212> DNA
<213> Homo sapiens

<220> 
<223> Human dexyhypusine synthase mRNA nucleotide sequence

<400> 9
taggggcagc tttgactcga gagccggcta taggcgcatg gaaggttccc tggaacggga      60

ggcgccagcg ggggcgctgg ccgccgtgct aaagcacagc tcgacgttgc cgcccgaaag     120

cacccaggtc cggggctacg acttcaaccg cggtgtgaat taccgcgcac tgctggaggc     180

cttcggcacc accggcttcc aagcaaccaa cttcgggcgc gctgtacagc aagtcaatgc     240

catgatcgag aagaagctgg aaccactgtc acaggatgaa gaccagcacg cggacctgac     300

ccagagccgc cgcccactta ccagctgcac cattttcctg ggatatacat ccaacctcat     360

cagttcaggc atccgtgaga ccattcgcta ccttgtgcag cacaacatgg tggacgtatt     420

ggtgaccaca gctggcggcg tggaggaaga cctcatcaag tgcctggcgc ccacatactt     480

gggcgagttt agcctcaggg ggaaggagct ccgggagaac gggatcaata ggatcggaaa     540

cctgctggtg cccaatgaga attactgcaa gtttgaggac tggctgatgc ccattctgga     600

ccagatggtg atggagcaga acacagaggg tgtaaagtgg acgccttcta agatgatcgc     660

ccggctgggc aaggagatca acaacccaga gtccgtgtat tactgggccc agaagaacca     720

catccctgtg tttagtcccg cacttacaga cggctcgctg ggcgacatga tcttcttcca     780

ttcctacaag aacccgggcc tggtcctgga catcgttgag gacctgaggc tcatcaacac     840

acaggccatc tttgccaagt gcactgggat gatcattctg ggcgggggcg tggtcaagca     900

ccacattgcc aatgccaacc tcatgcggaa cggggccgac tacgctgttt acatcaacac     960

agcccaggag tttgatggct ctgactcagg tgcccgacca gacgaggctg tctcctgggg    1020

caagatccgg gtggatgcac agcccgtcaa ggtctatgct gacgcctccc tggtcttccc    1080

cctgcttgtg gctgaaacct ttgcccagaa gatggatgcc ttcatgcatg agaagaacga    1140

ggactgagcg gctgcggtcc caggaaggtc ttaccccctc ttctatttat taatttgcag    1200

acccagcccc tcccctactt tttggtcagc tacgtctcta gaataagatg gtatctgaag    1260

tccttcc                                                              1267


<210> 10
<211> 369
<212> PRT
<213> Homo sapiens

<220> 
<223> Human dexyhypusine synthase amino acid sequence

<400> 10
Met Glu Gly Ser Leu Glu Arg Glu Ala Pro Ala Gly Ala Leu Ala Ala 
1               5                   10                  15      
Val Leu Lys His Ser Ser Thr Leu Pro Pro Glu Ser Thr Gln Val Arg 
            20                  25                  30          
Gly Tyr Asp Phe Asn Arg Gly Val Asn Tyr Arg Ala Leu Leu Glu Ala 
        35                  40                  45              
Phe Gly Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  
Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ser Gln Asp 
65                  70                  75                  80  
Glu Asp Gln His Ala Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Ser 
                85                  90                  95      
Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         
Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             
Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 
Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 
Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Glu Asn Tyr 
                165                 170                 175     
Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Met 
            180                 185                 190         
Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ala 
        195                 200                 205             
Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 
Gln Lys Asn His Ile Pro Val Phe Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 
Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     
Leu Asp Ile Val Glu Asp Leu Arg Leu Ile Asn Thr Gln Ala Ile Phe 
            260                 265                 270         
Ala Lys Cys Thr Gly Met Ile Ile Leu Gly Gly Gly Val Val Lys His 
        275                 280                 285             
His Ile Ala Asn Ala Asn Leu Met Arg Asn Gly Ala Asp Tyr Ala Val 
    290                 295                 300                 
Tyr Ile Asn Thr Ala Gln Glu Phe Asp Gly Ser Asp Ser Gly Ala Arg 
305                 310                 315                 320 
Pro Asp Glu Ala Val Ser Trp Gly Lys Ile Arg Val Asp Ala Gln Pro 
                325                 330                 335     
Val Lys Val Tyr Ala Asp Ala Ser Leu Val Phe Pro Leu Leu Val Ala 
            340                 345                 350         
Glu Thr Phe Ala Gln Lys Met Asp Ala Phe Met His Glu Lys Asn Glu 
        355                 360                 365             
Asp 
    

