                         SEQUENCE LISTING

<110>  University of Colorado Technology Transfer Office
 
<120>  COMPOSITIONS, METHODS AND USES FOR MULTIPLEXED TRACKABLE 
       GENOMICALLY-ENGINEERED POLYPEPTIDES

<130>  466888.000061

<150>  62/458,483
<151>  2017-02-13

<160>  143   

<170>  PatentIn version 3.5

<210>  1
<211>  12273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICC

<400>  1
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc ggagagccgt tcccactcgc tcctatgcaa     3540

cacgccatgt gggtagggcg gcacgaccac caacagctcg ggggagtagc aggccatctt     3600

tacgtcgagt ttgacggcgc gagagtcgac cccgatcggt tgcgcgctgc cgccacccga     3660

ctcgccctac gtcaccctat gttgagggta cagttcctgc ctgacggtac acaaaggatc     3720

cctccagccg caggctcgcg ggactttccc atcagcgttg cggatcttcg tcacgtagct     3780

cctgacgttg tcgatcaacg gctcgcgggt attagagacg caaagtctca tcaacagctt     3840

gatggagctg tcttcgagtt ggctctcact ctcctgccag gtgaaaggac gaggctgcac     3900

gtcgacctgg atatgcaagc tgctgacgcc atgagctaca ggatcctgct ggcggacttg     3960

gccgcactat acgacgggag agagccccca gcactcggtt acacgtatag agagtaccgc     4020

caggctattg aggccgagga aacattaccg caacctgttc gcgacgccga tagggactgg     4080

tgggcacaaa gaataccaca gcttccagac ccgcccgcac taccgacgcg tgccggtggt     4140

gagagagatc gccggcgctc gaccagaaga tggcactggt tagacccaca aacaagggac     4200

gccctcttcg cacgagcacg agctcgtggc atcacacctg caatgacact tgcggccgcg     4260

tttgcaaatg tcctcgcgag atggtccgcc tcttcccggt tcttactcaa tttgcccctt     4320

ttctcgcgcc aagcgttgca tccggacgta gacctcttgg taggtgactt cacatcgtcg     4380

ctgctgttag atgttgacct aggagataca gtgtctaatc ttgctcggaa gaaccaactg     4440

acttttacgg aggactggga acaccggcat tggagcggag tagagttgct gcgagaactc     4500

aaaaggcaac agcgttaccc acacggagcg cccgtggtgt tcacttctaa tcttgggcgc     4560

agtttatatt cttctcgggc ggagtccccc ttgggagagc ctgaatgggg aatttcgcaa     4620

acaccacagg tttggatcga ccatttagca tttgagcacc atggggaagt atggctccaa     4680

tgggactcga acgacgccct cttcccacct gctttagtcg agactctgtt tgacgcgtac     4740

tgtcaattga taaaccagct gtgcgacgat gaatccgcat ggcaaaagcc cttcgcggac     4800

atgatgccgg cgagtcagcg tgctattcgt gagcgggtga acgctaccgg cgcaccgatc     4860

ccggagggcc tcttacacga agggattttt cggatcgctc ttcaacagcc tcaggcgctc     4920

gcggtaacgg acatgcggta ccaatggaat agttatcgag agatgcggga acaggtcgtc     4980

gctttggcaa atctactccg agagcgcggg gtcaagccag gggactcagt cgctgtagcg     5040

cttcctcggt cagtcttcct aaccttggct ctccacgcga tcgtagaggc gggtgcggcg     5100

tggcttcccc tcgacacggg ctatccggac gatcggttga agatgatgct agaggatgca     5160

cgaccctctc tgttaatcac aaccgacgat caactcccca ggttctcaga cgtccctaat     5220

cttaccagtc tatgttacaa cgcgcccctc actccacaag gcagcgctcc tttacaactt     5280

agtcagccgc accataccgc ttatatcatt tttacgtccg gttccacggg caggccgaag     5340

ggtgtaatgg tgggccaaac tgcaatagtg aatagactat tgtggatgca aaaccactac     5400

ccgcttaccg gggaggacgt agtggctcaa aagactccct gctctttcga tgtcagcgtg     5460

tgggagttct tttggccttt tatagccggc gctaaattgg ttatggcgga gccggaagct     5520

caccgagacc ctttggccat gcaacagttc tttgcagagt atggagtcac aacgacgcat     5580

ttcgtcccat cgatgttagc cgcgttcgta gcatcattga cgccacaaac tgcgagacag     5640

tcatgtgcca cacttaagca agtcttctgc tctggtgagg cccttcctgc ggacctatgt     5700

cgggaatggc aacagcttac tggagccccc ttgcacaatc tttacgggcc gactgaggcc     5760

gcagttgacg tatcgtggta tccagcgttc ggggaggagc tagcccaagt gcgagggtct     5820

agtgttccaa ttggataccc ggtgtggaac acagggttaa ggatcctcga cgccatgatg     5880

catccggtac caccaggtgt cgctggggat ttgtacctga ctggcattca actggcacag     5940

ggttatctag ggcggcctga cttaacagct agccgattca tagcagatcc attcgctccc     6000

ggagagcgga tgtaccgaac aggcgacgtg gcacgctggt tagataatgg cgctgtcgag     6060

tatcttgggc ggtcagacga tcagttaaag atacgtggac aacggattga gcttggtgaa     6120

atagaccgag ttatgcaggc actaccagat gtcgagcaag ccgtagcctc ttgtgccatt     6180

gcgcgagaag acattcccgg gaacaagcac ttggttgcgt acatagtgcc gcaagaggag     6240

cagacctgca cagagcggtc acgttcaact ctcacagttt ccttcgtccg ttctttctta     6300

aaggagaaac taccagaata tatggtaccg tccgcgatcg tgatattaga cgctctgcca     6360

ctcacgccaa atggaaagtt ggatagaaga gctctgcctg ctcctgactt gcactcgcaa     6420

ctcctggata aatacgttgc tcccagaaac ccaatagaga ctattatcgc ggcagcattc     6480

tcttcattgc ttggatgcga cgtccaagat gcggacgcag atttctttgc gctcgggggc     6540

catagtctat tggccatgaa gctcgcagcg caattgtcga gacaggtagc acggcaagta     6600

acgcccgggc aagtcatggt cgcctcgaca gtcgcgaaac tcgcgaccat tatcgacgct     6660

gagctgccag tagaacagcc ttttgtgcac tcaccggaag agcggtatcg accattcgcg     6720

ttaacggatg ttcagcaagc ctacctggtc gggcgccagc cgggatttgc cctgggcggt     6780

gtaggctcgc atttcttcgt ggaattcgag atcgcagatc tcgacataca ccgcctggaa     6840

aaagtgtgga accgtttaat tgcacgtcat gatatgttgc gcgctgtggt tcgtgacggt     6900

cagcaacgtg tactggaaca gaccccgcca tgggtcatac cagcacatat tcttcacagt     6960

cctgaagagg cattacaggt tcgtgatcgt ttagctcacc aagtgttgaa ccccgaagtc     7020

tggccggtat ttgatctgca ggtgggcttc gttgacggta tgccggcccg tttatggttg     7080

tgccttgata acctgttatt ggacgggctg agcatgcaga ttcttctctc tgaactggag     7140

catggatatc gctacccaca gcaactccct cccccgttgc cgatcacttt tcgcgattat     7200

cttcagcaac cggcactccg taccccaaat cctgactcat tggcttggtg gcagacgcaa     7260

ctggatgaca tcccacctgc gcccgccctc ccgctacgtt gtctgcctca agatgttgaa     7320

accccgcgtt tcgcgcgtct gtacggcgca atggattctg ctcgttggcg tcgcctgaaa     7380

cagcgtgcgg ccgacgcaca tctgactccg tcagctgtcc tactgagcgt atggtctaca     7440

gtgctggcag cttggtcggc gcagccggat tttactctca acctgacatt attcgaccgg     7500

cgaccactgc accctcagat taatcaaatc cttggcgatt ttacctcact gatgttattg     7560

tcgtggcatc cgggtgagag ttggctgcag tccgcgcgtc ttctccagca acgcctttca     7620

gaatcgctca accaccgtga tgttagcgcc attcgcgtca tgcggcagct ggcgagaagg     7680

caaaatgtcc cggccgtacc catgccggtc gtatttacct ctgcgctggg gtttgaacag     7740

gataacttcc tggcccgtcg caatctactg aaaccggtgt ggggtatcag tcagacgccg     7800

caagtttggc tggaccatca ggtctatgaa tccgagggcg aactgcgttt taactgggat     7860

ttcgttgcgg ccctgtttcc ggacggtcaa gtggaacgtc agttcgcgca atactgcgcc     7920

ttattgaatc gcatggcaga agatgacagc tcttggcagt tgccgcttgc tgatctggtg     7980

cccccgttaa aagtgaccga gcggcgagcg agaaggctgc gtccagaacg cgcccagcct     8040

cgtattgcag ctgataagag ttccgttagt ctgatctgtg acacttttcg tgaggtggtt     8100

ggggaacccg tggcaccggc tgagaacttt ttcgaagcgg gagccacatc cctcaatctg     8160

gttcagctgc atgtccttct ccaacgtcac gaatttgcga ccttaacgct actggatttg     8220

ttcacccatc caagccctgt tgcattggct aactatcttg cgggtgtggc cctggaagag     8280

aaaacgaagc gcgtgcggcc ggttcggcga agacagcgtc gcattggaga gccgttccca     8340

ctcgctccta tgcaacacgc catgtgggta gggcggcacg accaccaaca gctcggggga     8400

gtagcaggcc atctttacgt cgagtttgac ggcgcgagag tcgaccccga tcggttgcgc     8460

gctgccgcca cccgactcgc cctacgtcac cctatgttga gggtacagtt cctgcctgac     8520

ggtacacaaa ggatccctcc agccgcaggc tcgcgggact ttcccatcag cgttgcggat     8580

cttcgtcacg tagctcctga cgttgtcgat caacggctcg cgggtattag agacgcaaag     8640

tctcatcaac agcttgatgg agctgtcttc gagttggctc tcactctcct gccaggtgaa     8700

aggacgaggc tgcacgtcga cctggatatg caagctgctg acgccatgag ctacaggatc     8760

ctgctggcgg acttggccgc actatacgac gggagagagc ccccagcact cggttacacg     8820

tatagagagt accgccaggc tattgaggcc gaggaaacat taccgcaacc tgttcgcgac     8880

gccgataggg actggtgggc acaaagaata ccacagcttc cagacccgcc cgcactaccg     8940

acgcgtgccg gtggtgagag agatcgccgg cgctcgacca gaagatggca ctggttagac     9000

ccacaaacaa gggacgccct cttcgcacga gcacgagctc gtggcatcac acctgcaatg     9060

acacttgcgg ccgcgtttgc aaatgtcctc gcgagatggt ccgcctcttc ccggttctta     9120

ctcaatttgc cccttttctc gcgccaagcg ttgcatccgg acgtagacct cttggtaggt     9180

gacttcacat cgtcgctgct gttagatgtt gacctaggag atacagtgtc taatcttgct     9240

cggaagaacc aactgacttt tacggaggac tgggaacacc ggcattggag cggagtagag     9300

ttgctgcgag aactcaaaag gcaacagcgt tacccacacg gagcgcccgt ggtgttcact     9360

tctaatcttg ggcgcagttt atattcttct cgggcggagt cccccttggg agagcctgaa     9420

tggggaattt cgcaaacacc acaggtttgg atcgaccatt tagcatttga gcaccatggg     9480

gaagtatggc tccaatggga ctcgaacgac gccctcttcc cacctgcttt agtcgagact     9540

ctgtttgacg cgtactgtca attgataaac cagctgtgcg acgatgaatc cgcatggcaa     9600

aagcccttcg cggacatgat gccggcgagt cagcgtgcta ttcgtgagcg ggtgaacgct     9660

accggcgcac cgatcccgga gggcctctta cacgaaggga tttttcggat cgctcttcaa     9720

cagcctcagg cgctcgcggt aacggacatg cggtaccaat ggaatagtta tcgagagatg     9780

cgggaacagg tcgtcgcttt ggcaaatcta ctccgagagc gcggggtcaa gccaggggac     9840

tcagtcgctg tagcgcttcc tcggtcagtc ttcctaacct tggctctcca cgcgatcgta     9900

gaggcgggtg cggcgtggct tcccctcgac acgggctatc cggacgatcg gttgaagatg     9960

atgctagagg atgcacgacc ctctctgtta atcacaaccg acgatcaact ccccaggttc    10020

tcagacgtcc ctaatcttac cagtctatgt tacaacgcgc ccctcactcc acaaggcagc    10080

gctcctttac aacttagtca gccgcaccat accgcttata tcatttttac gtccggttcc    10140

acgggcaggc cgaagggtgt aatggtgggc caaactgcaa tagtgaatag actattgtgg    10200

atgcaaaacc actacccgct taccggggag gacgtagtgg ctcaaaagac tccctgctct    10260

ttcgatgtca gcgtgtggga gttcttttgg ccttttatag ccggcgctaa attggttatg    10320

gcggagccgg aagctcaccg agaccctttg gccatgcaac agttctttgc agagtatgga    10380

gtcacaacga cgcatttcgt cccatcgatg ttagccgcgt tcgtagcatc attgacgcca    10440

caaactgcga gacagtcatg tgccacactt aagcaagtct tctgctctgg tgaggccctt    10500

cctgcggacc tatgtcggga atggcaacag cttactggag cccccttgca caatctttac    10560

gggccgactg aggccgcagt tgacgtatcg tggtatccag cgttcgggga ggagctagcc    10620

caagtgcgag ggtctagtgt tccaattgga tacccggtgt ggaacacagg gttaaggatc    10680

ctcgacgcca tgatgcatcc ggtaccacca ggtgtcgctg gggatttgta cctgactggc    10740

attcaactgg cacagggtta tctagggcgg cctgacttaa cagctagccg attcatagca    10800

gatccattcg ctcccggaga gcggatgtac cgaacaggcg acgtggcacg ctggttagat    10860

aatggcgctg tcgagtatct tgggcggtca gacgatcagt taaagatacg tggacaacgg    10920

attgagcttg gtgaaataga ccgagttatg caggcactac cagatgtcga gcaagccgta    10980

gcctcttgtg ccattgcgcg agaagacatt cccgggaaca agcacttggt tgcgtacata    11040

gtgccgcaag aggagcagac ctgcacagag cggtcacgtt caactctcac agtttccttc    11100

gtccgttctt tcttaaagga gaaactacca gaatatatgg taccgtccgc gatcgtgata    11160

ttagacgctc tgccactcac gccaaatgga aagttggata gaagagctct gcctgctcct    11220

gacttgcact cgcaactcct ggataaatac gttgctccca gaaacccaat agagactatt    11280

atcgcggcag cattctcttc attgcttgga tgcgacgtcc aagatgcgga cgcagatttc    11340

tttgcgctcg ggggccatag tctattggcc atgaagctcg cagcgcaatt gtcgagacag    11400

gtagcacggc aagtaacgcc cgggcaagtc atggtcgcct cgacagtcgc gaaactcgcg    11460

accattatcg acgctgagac atccggggaa gataacccta tccccctatg tcaaggcgat    11520

ggggaggaga tgagcacatg gctacgtcgt tttggacccc cagtcgaaca tcgggccagg    11580

ctagtgtgtt tcccccacgc aggcgcagcg gcggattcat acttagacct agcaagagcg    11640

ttagcaccag agatcgatgt tcatgctgtt caataccccg gcaggcaaga cagaagggac    11700

gaggagccat taggaaccgc aggtgaaatt gcagatgaag tggcagcggt gctacgtgcg    11760

tcgggagggg atgggccttt tgcacttttc ggccacagta tgggcgccct catcgcgtac    11820

gagacagcaa ggcgattaga gagggaaccg ggagggggac ccttacgttt attcgtgagc    11880

ggacaaacag cgccacgtgt ccatgaacga agaactgatc tgcccggtga cgatggactc    11940

gtggacgagc ttaggcgact tggcacctcc gaggcagcgc tcgcagacga agccctgctg    12000

gctatgtctc tcccggtgct cagggcggat tatagggtgt taagatccta cgcttgggcg    12060

gatggtcccc cactacgcgc cggtataact gccctctgcg gtgatgcaga cccactaact    12120

gcaacagggg atgcggaacg ctggttacaa cattccgtga ttccgggtcg gacacggaca    12180

tttcccggtg ggcattttta tttaggggaa caagtgaccg aggtggcagg ggctgtccgt    12240

agagatttac tgagagcagg gttagcgggt tga                                 12273


<210>  2
<211>  13596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICH

<400>  2
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc ggagagccgt tcccactcgc tcctatgcaa     3540

cacgccatgt gggtagggcg gcacgaccac caacagctcg ggggagtagc aggccatctt     3600

tacgtcgagt ttgacggcgc gagagtcgac cccgatcggt tgcgcgctgc cgccacccga     3660

ctcgccctac gtcaccctat gttgagggta cagttcctgc ctgacggtac acaaaggatc     3720

cctccagccg caggctcgcg ggactttccc atcagcgttg cggatcttcg tcacgtagct     3780

cctgacgttg tcgatcaacg gctcgcgggt attagagacg caaagtctca tcaacagctt     3840

gatggagctg tcttcgagtt ggctctcact ctcctgccag gtgaaaggac gaggctgcac     3900

gtcgacctgg atatgcaagc tgctgacgcc atgagctaca ggatcctgct ggcggacttg     3960

gccgcactat acgacgggag agagccccca gcactcggtt acacgtatag agagtaccgc     4020

caggctattg aggccgagga aacattaccg caacctgttc gcgacgccga tagggactgg     4080

tgggcacaaa gaataccaca gcttccagac ccgcccgcac taccgacgcg tgccggtggt     4140

gagagagatc gccggcgctc gaccagaaga tggcactggt tagacccaca aacaagggac     4200

gccctcttcg cacgagcacg agctcgtggc atcacacctg caatgacact tgcggccgcg     4260

tttgcaaatg tcctcgcgag atggtccgcc tcttcccggt tcttactcaa tttgcccctt     4320

ttctcgcgcc aagcgttgca tccggacgta gacctcttgg taggtgactt cacatcgtcg     4380

ctgctgttag atgttgacct aggagataca gtgtctaatc ttgctcggaa gaaccaactg     4440

acttttacgg aggactggga acaccggcat tggagcggag tagagttgct gcgagaactc     4500

aaaaggcaac agcgttaccc acacggagcg cccgtggtgt tcacttctaa tcttgggcgc     4560

agtttatatt cttctcgggc ggagtccccc ttgggagagc ctgaatgggg aatttcgcaa     4620

acaccacagg tttggatcga ccatttagca tttgagcacc atggggaagt atggctccaa     4680

tgggactcga acgacgccct cttcccacct gctttagtcg agactctgtt tgacgcgtac     4740

tgtcaattga taaaccagct gtgcgacgat gaatccgcat ggcaaaagcc cttcgcggac     4800

atgatgccgg cgagtcagcg tgctattcgt gagcgggtga acgctaccgg cgcaccgatc     4860

ccggagggcc tcttacacga agggattttt cggatcgctc ttcaacagcc tcaggcgctc     4920

gcggtaacgg acatgcggta ccaatggaat agttatcgag agatgcggga acaggtcgtc     4980

gctttggcaa atctactccg agagcgcggg gtcaagccag gggactcagt cgctgtagcg     5040

cttcctcggt cagtcttcct aaccttggct ctccacgcga tcgtagaggc gggtgcggcg     5100

tggcttcccc tcgacacggg ctatccggac gatcggttga agatgatgct agaggatgca     5160

cgaccctctc tgttaatcac aaccgacgat caactcccca ggttctcaga cgtccctaat     5220

cttaccagtc tatgttacaa cgcgcccctc actccacaag gcagcgctcc tttacaactt     5280

agtcagccgc accataccgc ttatatcatt tttacgtccg gttccacggg caggccgaag     5340

ggtgtaatgg tgggccaaac tgcaatagtg aatagactat tgtggatgca aaaccactac     5400

ccgcttaccg gggaggacgt agtggctcaa aagactccct gctctttcga tgtcagcgtg     5460

tgggagttct tttggccttt tatagccggc gctaaattgg ttatggcgga gccggaagct     5520

caccgagacc ctttggccat gcaacagttc tttgcagagt atggagtcac aacgacgcat     5580

ttcgtcccat cgatgttagc cgcgttcgta gcatcattga cgccacaaac tgcgagacag     5640

tcatgtgcca cacttaagca agtcttctgc tctggtgagg cccttcctgc ggacctatgt     5700

cgggaatggc aacagcttac tggagccccc ttgcacaatc tttacgggcc gactgaggcc     5760

gcagttgacg tatcgtggta tccagcgttc ggggaggagc tagcccaagt gcgagggtct     5820

agtgttccaa ttggataccc ggtgtggaac acagggttaa ggatcctcga cgccatgatg     5880

catccggtac caccaggtgt cgctggggat ttgtacctga ctggcattca actggcacag     5940

ggttatctag ggcggcctga cttaacagct agccgattca tagcagatcc attcgctccc     6000

ggagagcgga tgtaccgaac aggcgacgtg gcacgctggt tagataatgg cgctgtcgag     6060

tatcttgggc ggtcagacga tcagttaaag atacgtggac aacggattga gcttggtgaa     6120

atagaccgag ttatgcaggc actaccagat gtcgagcaag ccgtagcctc ttgtgccatt     6180

gcgcgagaag acattcccgg gaacaagcac ttggttgcgt acatagtgcc gcaagaggag     6240

cagacctgca cagagcggtc acgttcaact ctcacagttt ccttcgtccg ttctttctta     6300

aaggagaaac taccagaata tatggtaccg tccgcgatcg tgatattaga cgctctgcca     6360

ctcacgccaa atggaaagtt ggatagaaga gctctgcctg ctcctgactt gcactcgcaa     6420

ctcctggata aatacgttgc tcccagaaac ccaatagaga ctattatcgc ggcagcattc     6480

tcttcattgc ttggatgcga cgtccaagat gcggacgcag atttctttgc gctcgggggc     6540

catagtctat tggccatgaa gctcgcagcg caattgtcga gacaggtagc acggcaagta     6600

acgcccgggc aagtcatggt cgcctcgaca gtcgcgaaac tcgcgaccat tatcgacgct     6660

gagcctggaa ttggggcgct agttcccgct cccgtggtaa tcgcagcagg ccgtacggag     6720

gaaccaattg ccatagtatc catggcttgc cggttacccg gtggtgtgaa taccccacag     6780

agactatggg aattattacg tgaaggggga gaaaccctca gtggcttccc taccgaccga     6840

gggtgggacc tcgcgaggtt gcatcaccca gacccagaca accccggtac gtcatacgtt     6900

gataaagggg gattcctgga cgatgcggca gggtttgacg cagaattttt cggtgtgagc     6960

cccagagaag cagcggctat ggacccgcag cagagattac tcctcgaaac cagctgggag     7020

ttagtcgaga atgcagggat tgatccacat agcctaaggg ggaccgccac tggtgtcttc     7080

ctcggcgttg ccaagtttgg gtatggcgag gatacggcag ctgccgaaga cgtcgagggg     7140

tactctgtca ctggtgtagc cccggcagtg gcgtcgggca gaattagtta cacgatgggg     7200

ttggaagggc cgtctatttc ggttgatacc gcctgttcct ccagtctggt tgcactccac     7260

cttgcagtcg agtcgctccg gaaaggagaa agcagtatgg ccgtggtcgg gggagcggcg     7320

gtgatggcca caccgggtgt gtttgtggat ttttcccgac agagagcctt ggccgcggat     7380

gggcgttcaa aggcgttcgg agcaggtgca gacgggtttg gatttagcga aggtgtgaca     7440

ctggttctcc tagaaagatt aagtgaagcc cggcgtaacg gccatgaggt gctggcagtt     7500

gttagaggtt ccgcattaaa ccaggacggg gcttcgaacg ggctgagcgc cccctcgggc     7560

ccggcacaga gaagagtgat acgccaagca ctcgaatcgt gtggcctaga accaggtgac     7620

gttgacgcgg tggaagcgca cgggacagga actgcgttag gggacccgat agaagcaaac     7680

gccttgctgg acacttatgg tagagatcgt gatgcggatc gacccctctg gttaggaagt     7740

gttaagtcaa atataggaca cactcaggca gcggcgggag taactgggct gctcaaagta     7800

gtcctagcct tacgcaatgg ggaactaccc gccaccctac atgtcgagga accgacaccg     7860

catgtggatt ggtcgagcgg gggagttgct ctcttggcgg gtaatcagcc gtggcgaaga     7920

ggtgaacgaa cccgtagagc cgccgtgtcc gcattcggga tcagtggtac gaacgcgcac     7980

gtgattgtgg aagaagctcc acaagaggtg agaccagcgc ccggtcaagg actctcgccc     8040

gcggtgtcaa ccttggtagt ggcgggtaaa actatgcagc gtgtttcggc aaccgccggt     8100

atgctcgcag attggatgga aggcccaggt gcagatgtgg cgctggcgga cgtggcgcac     8160

acgttaaatc atcaccgttc acggcaacca aagttcggta cggtggtggc cagggaccgg     8220

acacaggcaa tcgccggact aagagcgctg gcggcgggtc agcacgcccc aggggttgtt     8280

aaccctgctg aaggaagtcc aggtccaggg acggtgttcg tgtttcctgg ccaggggtcc     8340

cagcgtgcag gcatggggga ggagttggct gcggctttcc ccgtgtttgc cagaatccac     8400

cagcaagtgt gggatttact cgatgttcct gatctcgacg ttaacgaaac ggggtacgca     8460

caaccagcac tcttcgcact ccaagtggcg ctgtttgggc tcctcgaatc atggggagta     8520

cggccggatg ccgtggtcgg gcatagtgta ggggaattag cggcagggta cgtttccggg     8580

ctttggagtc ttgaggatgc ttgcacgctc gtgtcggcga gagcccgtct aatgcaagcc     8640

ttaccggcag gtggtgttat ggcggcagtt ccagtgtccg aagacgaagc acgggctgtg     8700

ttgggggaag gagtcgaaat agctgcggtc aacggtccgt cgagcgtggt tctaagcggt     8760

gatgaagcag cagtgctcca ggccgcggaa gggttaggca agtggacgcg attaccgacc     8820

tcgcatgcat tccattctgc tcgtatggaa ccaatgctgg aagagtttag agcagtggcg     8880

gaaggtctaa catacaggac tccccaggtg gcaatggccg ccggagacca ggttatgacc     8940

gctgaatact gggtgcgtca ggttagggat acagttcgtt ttggcgagca agttgcctcg     9000

ttcgaggatg ctgtattcgt ggaattggga gcagatcgct ctcttgcacg gctagtcgat     9060

ggtatcgcga tgttgcacgg ggatcatgag gcacaggctg gtatgcggag agaacaaccc     9120

ttgcccttag gtttacgaag attgctaacc gacctgcata acgctggtgc tgccgtcgat     9180

tttagtgttt tgtgcccaca aggtcgtctg gttgacgcac cgttaccagc ctggtcacac     9240

cggtttctct tctatgaccg ggaaggagtg gacaatagat caccaggggg aagcacagtg     9300

gcggtccacc cgcttttact agccgcggtg gatgtgccgg gccacggtgg agcggttttc     9360

acgggtagac tctcgactga cgagcaaccg tggttagcgg agcacgttgt cgggggaaga     9420

accctagttc ctggttctgt tttagtcgat ctagccttag cggcaggcga agacgtaggg     9480

ctaccggtgt tagaagaatt agtattgcag aggccgctgg tgcttgccgg cgcgggagca     9540

ctcctacgga tgtcggtcgg ggcaccagac gagagcggta gaagaactat cgatgttcac     9600

gcagctgaag acgtcgccga tttagcagat gcccaatggt cccagcacgc caccgggact     9660

ttagcccaag gggtagcggc ggggcccagg gacacagagc aatggccccc agaggatgcc     9720

gtccggattc cattagacga ccattatgat ggtctcgcgg aacagggtta tgagtacggt     9780

ccgtcgtttc aggcgctagt ggcctacgtg gcggaggatg cgactgcgac aatgttagcg     9840

gaagtcgcgc ttccgggcag cattagatcg caacaaggtc tatacgccat ccatcccgca     9900

ctgctggacg cttgttttca atctgtcgga gcccacccag acagtcaatc cgtcgggtca     9960

ggtctactcg tacccctcgg tgttcggaga gttcgtgcgt acgcacccgt aaggaccgcc    10020

cgttattgtt acacccgcgt cacgaaagtt gaactagctg gggttgaggc cgacatcgac    10080

gttctggatg ctcacggcac agtgcttcta gccgtgtgcg gtcttcgtat cgggaccgga    10140

gtgagcgaga gggacaaaca caacagagtt ctcaatgagc gcctactcac catcgaatgg    10200

catcagcgtg aactaccaga aatggacccc tcgggtgccg ggaagtggct cctaatctcg    10260

gactgtgcag catccgatgt caccgctaca cgactggctg atgccttccg ggagcacagc    10320

gctgcgtgca ctaccatgcg gtggccactt cacgatgatc aactagcagc cgccgaccaa    10380

ctccgggacc aggtgggttc agatgagttt tctggcgtgg tagtactaac agggccaaac    10440

acagggaccc ctcatcaggg ttccgcagac cgtggcgccg agtacgttag gcggttagtt    10500

ggaatcgctc gtgaacttag cgatcttccc ggagcggttc cccgtatgta tgtcgtcaca    10560

aggggagcgc agagagtcct tgccgatgat tgtgttaatt tagaacaggg agggctcaga    10620

ggtctgctga ggaccatcgg tgctgagcac ccacatctcc gcgccaccca aattgatgtt    10680

gatgagcaga caggagtaga gcagctggcg cgacaactcc tagctacatc ggaggaagac    10740

gagacagcct ggagggacaa cgaatggtac gttgcgaggt tatgccccac acccctgagg    10800

ccacaggaac gtaggacaat agtggcggac catcaacagt ctggtatgcg gttacaaata    10860

cgtacgcccg gtgcaatcga tagtgtggcc tttgaacccg cacccgatgt agagcaaccc    10920

ttacgggcgg gtgaagttcg ggttgacgtt agagcaaccg gtgttaattt ccgtgacgtt    10980

ctactcgctc tcgggatgta tccccagaaa gctgacatgg ggacagaagc agctggtgtt    11040

gtaacagcag tgggacctga tgtcgatgcg tttgcgcctg gtgatagagt tctagggcta    11100

ttccaagggg catttgctcc aattgcggtg actgaccatc gtttactggc acgggtgcca    11160

gacgggtggt cagatgccga tgcggcggcg gtgccaatag cttacacgac agcacattat    11220

gcgctgcacg acctggcggg gttgcgggcg gggcaatctg tcctgataca cgcggcagcg    11280

ggtggtgttg gtatggccgc tgttgcactg gcacggaggg ccggcgcaga agttctggct    11340

accgcaggac ctgcaaaaca cggtacgcta cgggcattag ggctagatga tgaacacatc    11400

gcttcgagtc gggagaccgg gttcgcgcgt aagttccgag agcggactgg gggacgagga    11460

gtggacgtcg ttctaaacag cttgaccggc gaactattag acgagtccgc ggatctcctc    11520

gcggaggacg gagtcttcgt ggaaatggga aagactgatc tgcgcgatgc aggggacttt    11580

cgtgggcgct acgccccgtt tgatctaggg gaagcaggcg atgacaggct cggggaaatt    11640

ctacgtgagg tggtgggact gctcggtgca ggggaactcg accgactccc tgttagcgcg    11700

tgggaattgg ggatacccca gacggggaag tcgttagtga cgctgccacc cgaacaagcg    11760

caagttttca gaccagacgg cactgtattg atcaccgggg gaacgggaac gttaggtcgg    11820

ctgctggccc gtcatctggt tacagagcac ggggtgcgtc acctgctgct agtgtcgagg    11880

agaggagcag atgcccctgg atcggacgag ctgagggccg aaatcgagga tctcggagca    11940

tcagcggaaa ttgcagcatg tgatacagcc gatcgagacg ctctcagcgc gttgctagat    12000

ggactgccga ggccactgac cggagtagtt cacgccgcgg gagtcctcgc tgacggtctg    12060

gttacatcca tcgacgagcc cgcagtcgaa caagttctcc gtgcaaaagt tgatgcggcc    12120

tggaacctgc acgagctaac tgcgaacacc ggtctcagct ttttcgtgct gttctcgtca    12180

gccgcaagtg tgttagcggg gccggggcag ggagtatatg cggcagcgaa cgaatcttta    12240

aacgctctgg ccgctctgcg taggactagg ggtttacccg caaaagcatt gggatgggga    12300

ttatgggcga tagggcgtgc aatagcattt gccgagcaga ccggtgacgc aatcgccccg    12360

gaggaaggcg cgtacgcctt cgagacacta ctcagacata acagggcgta ctcgggttac    12420

gctcccgtga tagggtcacc atggctgact gcgttcgccc aacattcgcc ctttgcggag    12480

aagttccagt ccctggggca aaatagatcc gggacgtcta agtttctggc agaattagtc    12540

gatctgccaa gagaagaatg gccagatcgg ttacgtcgtc tattagaact ggtgaggtct    12600

catgctgccg cagtttcggg gtatggatcg gcagaccaat taccagaaag aaaagcattc    12660

aaagacctcg gattcgattc actggcagca gtcgaactaa gaaatcgtct agggaccgcg    12720

acaggcgtcc ggctgcccag tactctggtg ttcgaccacc caaccccact tgcggttgcg    12780

gaacatctac gtgatcgtct aacatccggg gaagataacc ctatccccct atgtcaaggc    12840

gatggggagg agatgagcac atggctacgt cgttttggac ccccagtcga acatcgggcc    12900

aggctagtgt gtttccccca cgcaggcgca gcggcggatt catacttaga cctagcaaga    12960

gcgttagcac cagagatcga tgttcatgct gttcaatacc ccggcaggca agacagaagg    13020

gacgaggagc cattaggaac cgcaggtgaa attgcagatg aagtggcagc ggtgctacgt    13080

gcgtcgggag gggatgggcc ttttgcactt ttcggccaca gtatgggcgc cctcatcgcg    13140

tacgagacag caaggcgatt agagagggaa ccgggagggg gacccttacg tttattcgtg    13200

agcggacaaa cagcgccacg tgtccatgaa cgaagaactg atctgcccgg tgacgatgga    13260

ctcgtggacg agcttaggcg acttggcacc tccgaggcag cgctcgcaga cgaagccctg    13320

ctggctatgt ctctcccggt gctcagggcg gattataggg tgttaagatc ctacgcttgg    13380

gcggatggtc ccccactacg cgccggtata actgccctct gcggtgatgc agacccacta    13440

actgcaacag gggatgcgga acgctggtta caacattccg tgattccggg tcggacacgg    13500

acatttcccg gtgggcattt ttatttaggg gaacaagtga ccgaggtggc aggggctgtc    13560

cgtagagatt tactgagagc agggttagcg ggttga                              13596


<210>  3
<211>  11943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICO

<400>  3
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc ggagagccgt tcccactcgc tcctatgcaa     3540

cacgccatgt gggtagggcg gcacgaccac caacagctcg ggggagtagc aggccatctt     3600

tacgtcgagt ttgacggcgc gagagtcgac cccgatcggt tgcgcgctgc cgccacccga     3660

ctcgccctac gtcaccctat gttgagggta cagttcctgc ctgacggtac acaaaggatc     3720

cctccagccg caggctcgcg ggactttccc atcagcgttg cggatcttcg tcacgtagct     3780

cctgacgttg tcgatcaacg gctcgcgggt attagagacg caaagtctca tcaacagctt     3840

gatggagctg tcttcgagtt ggctctcact ctcctgccag gtgaaaggac gaggctgcac     3900

gtcgacctgg atatgcaagc tgctgacgcc atgagctaca ggatcctgct ggcggacttg     3960

gccgcactat acgacgggag agagccccca gcactcggtt acacgtatag agagtaccgc     4020

caggctattg aggccgagga aacattaccg caacctgttc gcgacgccga tagggactgg     4080

tgggcacaaa gaataccaca gcttccagac ccgcccgcac taccgacgcg tgccggtggt     4140

gagagagatc gccggcgctc gaccagaaga tggcactggt tagacccaca aacaagggac     4200

gccctcttcg cacgagcacg agctcgtggc atcacacctg caatgacact tgcggccgcg     4260

tttgcaaatg tcctcgcgag atggtccgcc tcttcccggt tcttactcaa tttgcccctt     4320

ttctcgcgcc aagcgttgca tccggacgta gacctcttgg taggtgactt cacatcgtcg     4380

ctgctgttag atgttgacct aggagataca gtgtctaatc ttgctcggaa gaaccaactg     4440

acttttacgg aggactggga acaccggcat tggagcggag tagagttgct gcgagaactc     4500

aaaaggcaac agcgttaccc acacggagcg cccgtggtgt tcacttctaa tcttgggcgc     4560

agtttatatt cttctcgggc ggagtccccc ttgggagagc ctgaatgggg aatttcgcaa     4620

acaccacagg tttggatcga ccatttagca tttgagcacc atggggaagt atggctccaa     4680

tgggactcga acgacgccct cttcccacct gctttagtcg agactctgtt tgacgcgtac     4740

tgtcaattga taaaccagct gtgcgacgat gaatccgcat ggcaaaagcc cttcgcggac     4800

atgatgccgg cgagtcagcg tgctattcgt gagcgggtga acgctaccgg cgcaccgatc     4860

ccggagggcc tcttacacga agggattttt cggatcgctc ttcaacagcc tcaggcgctc     4920

gcggtaacgg acatgcggta ccaatggaat agttatcgag agatgcggga acaggtcgtc     4980

gctttggcaa atctactccg agagcgcggg gtcaagccag gggactcagt cgctgtagcg     5040

cttcctcggt cagtcttcct aaccttggct ctccacgcga tcgtagaggc gggtgcggcg     5100

tggcttcccc tcgacacggg ctatccggac gatcggttga agatgatgct agaggatgca     5160

cgaccctctc tgttaatcac aaccgacgat caactcccca ggttctcaga cgtccctaat     5220

cttaccagtc tatgttacaa cgcgcccctc actccacaag gcagcgctcc tttacaactt     5280

agtcagccgc accataccgc ttatatcatt tttacgtccg gttccacggg caggccgaag     5340

ggtgtaatgg tgggccaaac tgcaatagtg aatagactat tgtggatgca aaaccactac     5400

ccgcttaccg gggaggacgt agtggctcaa aagactccct gctctttcga tgtcagcgtg     5460

tgggagttct tttggccttt tatagccggc gctaaattgg ttatggcgga gccggaagct     5520

caccgagacc ctttggccat gcaacagttc tttgcagagt atggagtcac aacgacgcat     5580

ttcgtcccat cgatgttagc cgcgttcgta gcatcattga cgccacaaac tgcgagacag     5640

tcatgtgcca cacttaagca agtcttctgc tctggtgagg cccttcctgc ggacctatgt     5700

cgggaatggc aacagcttac tggagccccc ttgcacaatc tttacgggcc gactgaggcc     5760

gcagttgacg tatcgtggta tccagcgttc ggggaggagc tagcccaagt gcgagggtct     5820

agtgttccaa ttggataccc ggtgtggaac acagggttaa ggatcctcga cgccatgatg     5880

catccggtac caccaggtgt cgctggggat ttgtacctga ctggcattca actggcacag     5940

ggttatctag ggcggcctga cttaacagct agccgattca tagcagatcc attcgctccc     6000

ggagagcgga tgtaccgaac aggcgacgtg gcacgctggt tagataatgg cgctgtcgag     6060

tatcttgggc ggtcagacga tcagttaaag atacgtggac aacggattga gcttggtgaa     6120

atagaccgag ttatgcaggc actaccagat gtcgagcaag ccgtagcctc ttgtgccatt     6180

gcgcgagaag acattcccgg gaacaagcac ttggttgcgt acatagtgcc gcaagaggag     6240

cagacctgca cagagcggtc acgttcaact ctcacagttt ccttcgtccg ttctttctta     6300

aaggagaaac taccagaata tatggtaccg tccgcgatcg tgatattaga cgctctgcca     6360

ctcacgccaa atggaaagtt ggatagaaga gctctgcctg ctcctgactt gcactcgcaa     6420

ctcctggata aatacgttgc tcccagaaac ccaatagaga ctattatcgc ggcagcattc     6480

tcttcattgc ttggatgcga cgtccaagat gcggacgcag atttctttgc gctcgggggc     6540

catagtctat tggccatgaa gctcgcagcg caattgtcga gacaggtagc acggcaagta     6600

acgcccgggc aagtcatggt cgcctcgaca gtcgcgaaac tcgcgaccat tatcgacgct     6660

gagcctggaa ttggggcgct agttcccgct cccgtggtaa tcgcagcagg ccgtacggag     6720

gaaccaattg ccatcgtttc gatggcatgt cgtttaccgg gaggagtcaa tacgccccaa     6780

cggctctggg aattactacg ggagggtggt gaaaccttgt ccgggttccc aacggaccgt     6840

ggctgggacc tagcacggct tcaccaccct gatccggaca accccggaac gagctacgtt     6900

gataagggtg gatttctcga cgacgcggcg ggtttcgacg cagagttttt cggggtttca     6960

ccaagggaag ctgccgctat ggaccctcag caacgattac ttttagagac ctcgtgggag     7020

ctagttgaaa atgcgggcat agatccacat agcctgcgag ggacagcgac aggggtgttc     7080

ctaggagttg cgaagtttgg ttatggtgag gacacagcag cagcggaaga tgttgaaggt     7140

tattcagtta ccggtgttgc tcccgctgtg gcatctggcc gcatatccta cactatgggt     7200

ttagaaggtc cttccatctc ggtcgatacc gcatgctcaa gctcgctagt cgcgcttcat     7260

ctagccgtag agtccctccg aaagggtgag tcatctatgg cggtggtggg tggtgcagcc     7320

gttatggcga ctcctggggt atttgttgat ttttcacgcc aacgggcgct tgccgcagac     7380

ggccgttcca aagcgttcgg ggcaggtgca gatggttttg gtttcagcga gggagtcacg     7440

ctggttctac tagagcgttt aagtgaggcg cgtcgtaacg gtcatgaagt tctagctgta     7500

gtgcgcgggt ccgcgttaaa ccaggacgga gcgagcaacg gactttcagc accctccggc     7560

cctgcgcaac gtagagtaat aaggcaagcg ctcgaatcgt gtgggcttga accgggggat     7620

gttgacgcgg ttgaggcgca tggtactggt acagcactag gtgacccaat agaggccaat     7680

gcgctgttgg acacttacgg gcgagaccgt gatgcggatc gtccactttg gttggggtcc     7740

gttaagagca atattgggca cactcaagct gcggccgggg ttacaggact gctgaaggtt     7800

gtgttagcac tgcgcaatgg tgagctacct gcaacgttac atgtcgagga accaactcca     7860

cacgtcgatt ggtcctcagg tggtgtcgca ttactggcgg gtaatcaacc atggcgaagg     7920

ggagaaagga ccagaagggc ggcagtgagc gcctttggta tctccggtac aaatgctcac     7980

gtgatagtgg aagaggcgcc tcaggaagtt cgacccgccc ctggccaagg gctgtcgcca     8040

gccgtgtcca cgttagttgt tgcaggtaaa accatgcagc gtgtaagtgc gacagctgga     8100

atgcttgcag actggatgga gggtcctggg gccgatgttg cattggcgga tgtggcccat     8160

accctgaacc atcaccgatc aagacagccc aagttcggga cggttgtagc gcgtgacagg     8220

actcaggcga tagctgggct ccgtgcattg gcggctggtc aacatgctcc tggggtcgtc     8280

aacccagctg aaggttcccc aggaccaggc accgtgttcg tttttcccgg tcaaggttcg     8340

cagagggcag ggatggggga ggaactcgcg gcagcctttc ctgtcttcgc tcgaatacat     8400

cagcaagttt gggacctcct agatgttccc gacctcgacg ttaatgaaac cgggtacgcc     8460

caaccagcgc tgttcgcgct tcaggtcgcg ctctttggcc ttctggagtc gtggggtgtt     8520

aggccagatg cagtggtagg gcactcagtt ggtgagctgg ccgcggggta cgtgtccggt     8580

ctttggtcac tagaggacgc ctgcacacta gtctcagcaa gagcgcgcct aatgcaggca     8640

ctgcctgctg gaggggtgat ggcggcagtc cccgtctccg aggatgaggc gcgggccgtc     8700

ctgggcgagg gagttgaaat tgcggctgtg aatggaccct cgtccgttgt gctctcaggg     8760

gacgaggcgg cagtcttaca ggccgccgaa ggtctaggta agtggacgcg actgccgacc     8820

agccatgctt ttcactcagc gagaatggaa cccatgctag aagagtttcg ggccgtagca     8880

gagggtctga cctatcgtac ccctcaagta gctatggctg ctggggatca ggtgatgaca     8940

gcagaatatt gggtgcggca ggttcgggac acagttcgct tcggggagca agtagcgtca     9000

ttcgaggatg cggtgtttgt tgagttaggc gctgacagaa gtctagcgcg tttggtggac     9060

ggcatcgcca tgctgcacgg tgaccacgaa gcgcaggccg cggaccatag gcaaatcacc     9120

gaagcggttg cggatgctta cgtcttaggc caccttccgg attttgcggc gctgcggcgg     9180

cctcacgcac gaaagttgga cttaccaact tatcccttcg agcgtagaca gtactggttc     9240

agagatgcgc gtgagaggcc ggaacaaccc agagataccg gcggacctcg cacagaagca     9300

gtccgtctgt tagaggatgg taggattgaa gaattagctg cacttttggg aggggccagt     9360

gatgaccaac acacattaca ggtgctgact aagttggcgg cgcaacataa ccaacaacga     9420

acaacccggt caatcgctga cgacaggtac gaaataaggt gggaccgatc gacttcccca     9480

ctatccggag cagatgttga ccaagcgggg agctggatcg tggtgtcaga tgacgcagat     9540

gccgttcccc cgctagtgga cttgctggct gcacgtaacg agccccatca ggttgttggt     9600

ctacccgctt cggacgcaga cgaggagagg ctcgcagaga ctctgcgtgc ggctgcgact     9660

gaagatgcta cccttcggat agtccacgtt gcggcgctcg aagcaggcgc tacccccagc     9720

atgcgttcac tgctccgcat gcagcaccga atactaggtg gcacgcggcg ggtgttcagg     9780

gcagcggtcg cagcggagtt aagaggtccc atttggatag tgacgcgggg agcacaaaga     9840

gtggctgaca ccgatacagt tgccccgcat cagtcatgcc tctggggatt tgggagggca     9900

gcatcgctgg agctgccgca cgtttggggt ggcctagcag atttatcaga gggcggtgac     9960

aatgcggccg atgagtggag tgcgctagtg gaccgcattg ccgcacccca cggttcagca    10020

gttagggagg accaactggc gctgagagac agggccgtat atacgccaag actggccaga    10080

cgttctgcgc ccccgagcgg gactccccta catctacgag gggatggcac agtgttaata    10140

acaggtggga ctggtacact aggtaggcta ttagcgcgtc acctagtaac agagcatggg    10200

gtgcggcatc tcttactagt ttcaaggaga ggcgccgatg cccctggctc ggatgaactg    10260

cgcgcagaaa tagaggactt aggtgccagc gcggagatcg cagcgtgtga tacagcggat    10320

cgcgatgccc tatctgccct actagatggt ctcccccggc cccttacggg tgtcgttcac    10380

gccgctggcg tgttagccga tggacttgtc actagcattg acgagcctgc ggtggaacag    10440

gttctccgag caaaggtgga cgcggcatgg aacctacacg aactcacagc taataccggg    10500

ctatcctttt tcgttctttt ctcatcagca gcatcggtcc tggcaggtcc agggcaagga    10560

gtttatgcgg ctgcaaatga atcgctcaac gcactagctg cgttaaggcg aactaggggt    10620

ctgccggcca aggctctggg atggggcctg tgggccatcg ggcgggcaat cgcttttgcg    10680

gagcagaccg gggacgccat cgctccagag gaaggagcat acgcttttga aactctgtta    10740

aggcataacc gtgcctactc gggatatgcg cccgtcattg gatctccctg gttgaccgcg    10800

ttcgcacagc attccccctt tgcagaaaaa ttccaatcac tcggacagaa tcggtcaggg    10860

acatcgaaat tcttagcgga gctagttgac ctgcctcgtg aggaatggcc ggataggctc    10920

aggagactac tagagttagt taggtcccat gccgccgcgg tctccggtta cggtagtgca    10980

gatcaactgc cggaaagaaa agcgttcaag gatttggggt ttgattcgct ggccgccgtt    11040

gaactgcgta accggctggg aacggctaca ggggtacgac tgccgtcaac cctagtattt    11100

gatcacccaa ctccgctggc cgtcgctgag cacttaagag ataggctaac atccggggaa    11160

gataacccta tccccctatg tcaaggcgat ggggaggaga tgagcacatg gctacgtcgt    11220

tttggacccc cagtcgaaca tcgggccagg ctagtgtgtt tcccccacgc aggcgcagcg    11280

gcggattcat acttagacct agcaagagcg ttagcaccag agatcgatgt tcatgctgtt    11340

caataccccg gcaggcaaga cagaagggac gaggagccat taggaaccgc aggtgaaatt    11400

gcagatgaag tggcagcggt gctacgtgcg tcgggagggg atgggccttt tgcacttttc    11460

ggccacagta tgggcgccct catcgcgtac gagacagcaa ggcgattaga gagggaaccg    11520

ggagggggac ccttacgttt attcgtgagc ggacaaacag cgccacgtgt ccatgaacga    11580

agaactgatc tgcccggtga cgatggactc gtggacgagc ttaggcgact tggcacctcc    11640

gaggcagcgc tcgcagacga agccctgctg gctatgtctc tcccggtgct cagggcggat    11700

tatagggtgt taagatccta cgcttgggcg gatggtcccc cactacgcgc cggtataact    11760

gccctctgcg gtgatgcaga cccactaact gcaacagggg atgcggaacg ctggttacaa    11820

cattccgtga ttccgggtcg gacacggaca tttcccggtg ggcattttta tttaggggaa    11880

caagtgaccg aggtggcagg ggctgtccgt agagatttac tgagagcagg gttagcgggt    11940

tga                                                                  11943


<210>  4
<211>  12282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICS

<400>  4
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc ggagagccgt tcccactcgc tcctatgcaa     3540

cacgccatgt gggtagggcg gcacgaccac caacagctcg ggggagtagc aggccatctt     3600

tacgtcgagt ttgacggcgc gagagtcgac cccgatcggt tgcgcgctgc cgccacccga     3660

ctcgccctac gtcaccctat gttgagggta cagttcctgc ctgacggtac acaaaggatc     3720

cctccagccg caggctcgcg ggactttccc atcagcgttg cggatcttcg tcacgtagct     3780

cctgacgttg tcgatcaacg gctcgcgggt attagagacg caaagtctca tcaacagctt     3840

gatggagctg tcttcgagtt ggctctcact ctcctgccag gtgaaaggac gaggctgcac     3900

gtcgacctgg atatgcaagc tgctgacgcc atgagctaca ggatcctgct ggcggacttg     3960

gccgcactat acgacgggag agagccccca gcactcggtt acacgtatag agagtaccgc     4020

caggctattg aggccgagga aacattaccg caacctgttc gcgacgccga tagggactgg     4080

tgggcacaaa gaataccaca gcttccagac ccgcccgcac taccgacgcg tgccggtggt     4140

gagagagatc gccggcgctc gaccagaaga tggcactggt tagacccaca aacaagggac     4200

gccctcttcg cacgagcacg agctcgtggc atcacacctg caatgacact tgcggccgcg     4260

tttgcaaatg tcctcgcgag atggtccgcc tcttcccggt tcttactcaa tttgcccctt     4320

ttctcgcgcc aagcgttgca tccggacgta gacctcttgg taggtgactt cacatcgtcg     4380

ctgctgttag atgttgacct aggagataca gtgtctaatc ttgctcggaa gaaccaactg     4440

acttttacgg aggactggga acaccggcat tggagcggag tagagttgct gcgagaactc     4500

aaaaggcaac agcgttaccc acacggagcg cccgtggtgt tcacttctaa tcttgggcgc     4560

agtttatatt cttctcgggc ggagtccccc ttgggagagc ctgaatgggg aatttcgcaa     4620

acaccacagg tttggatcga ccatttagca tttgagcacc atggggaagt atggctccaa     4680

tgggactcga acgacgccct cttcccacct gctttagtcg agactctgtt tgacgcgtac     4740

tgtcaattga taaaccagct gtgcgacgat gaatccgcat ggcaaaagcc cttcgcggac     4800

atgatgccgg cgagtcagcg tgctattcgt gagcgggtga acgctaccgg cgcaccgatc     4860

ccggagggcc tcttacacga agggattttt cggatcgctc ttcaacagcc tcaggcgctc     4920

gcggtaacgg acatgcggta ccaatggaat agttatcgag agatgcggga acaggtcgtc     4980

gctttggcaa atctactccg agagcgcggg gtcaagccag gggactcagt cgctgtagcg     5040

cttcctcggt cagtcttcct aaccttggct ctccacgcga tcgtagaggc gggtgcggcg     5100

tggcttcccc tcgacacggg ctatccggac gatcggttga agatgatgct agaggatgca     5160

cgaccctctc tgttaatcac aaccgacgat caactcccca ggttctcaga cgtccctaat     5220

cttaccagtc tatgttacaa cgcgcccctc actccacaag gcagcgctcc tttacaactt     5280

agtcagccgc accataccgc ttatatcatt tttacgtccg gttccacggg caggccgaag     5340

ggtgtaatgg tgggccaaac tgcaatagtg aatagactat tgtggatgca aaaccactac     5400

ccgcttaccg gggaggacgt agtggctcaa aagactccct gctctttcga tgtcagcgtg     5460

tgggagttct tttggccttt tatagccggc gctaaattgg ttatggcgga gccggaagct     5520

caccgagacc ctttggccat gcaacagttc tttgcagagt atggagtcac aacgacgcat     5580

ttcgtcccat cgatgttagc cgcgttcgta gcatcattga cgccacaaac tgcgagacag     5640

tcatgtgcca cacttaagca agtcttctgc tctggtgagg cccttcctgc ggacctatgt     5700

cgggaatggc aacagcttac tggagccccc ttgcacaatc tttacgggcc gactgaggcc     5760

gcagttgacg tatcgtggta tccagcgttc ggggaggagc tagcccaagt gcgagggtct     5820

agtgttccaa ttggataccc ggtgtggaac acagggttaa ggatcctcga cgccatgatg     5880

catccggtac caccaggtgt cgctggggat ttgtacctga ctggcattca actggcacag     5940

ggttatctag ggcggcctga cttaacagct agccgattca tagcagatcc attcgctccc     6000

ggagagcgga tgtaccgaac aggcgacgtg gcacgctggt tagataatgg cgctgtcgag     6060

tatcttgggc ggtcagacga tcagttaaag atacgtggac aacggattga gcttggtgaa     6120

atagaccgag ttatgcaggc actaccagat gtcgagcaag ccgtagcctc ttgtgccatt     6180

gcgcgagaag acattcccgg gaacaagcac ttggttgcgt acatagtgcc gcaagaggag     6240

cagacctgca cagagcggtc acgttcaact ctcacagttt ccttcgtccg ttctttctta     6300

aaggagaaac taccagaata tatggtaccg tccgcgatcg tgatattaga cgctctgcca     6360

ctcacgccaa atggaaagtt ggatagaaga gctctgcctg ctcctgactt gcactcgcaa     6420

ctcctggata aatacgttgc tcccagaaac ccaatagaga ctattatcgc ggcagcattc     6480

tcttcattgc ttggatgcga cgtccaagat gcggacgcag atttctttgc gctcgggggc     6540

catagtctat tggccatgaa gctcgcagcg caattgtcga gacaggtagc acggcaagta     6600

acgcccgggc aagtcatggt cgcctcgaca gtcgcgaaac tcgcgaccat tatcgacgct     6660

gagctgccag tagaacagcc ttttgtgcac tcaccggaag agcggtatcg accattcgcg     6720

ttaacggatg ttcagcaagc ctacctggtc gggcgccagc cgggatttgc cctgggcggt     6780

gtaggctcgc atttcttcgt ggaattcgag atcgcagatc tcgacataca ccgcctggaa     6840

aaagtgtgga accgtttaat tgcacgtcat gatatgttgc gcgctgtggt tcgtgacggt     6900

cagcaacgtg tactggaaca gaccccgcca tgggtcatac cagcacatat tcttcacagt     6960

cctgaagagg cattacaggt tcgtgatcgt ttagctcacc aagtgttgaa ccccgaagtc     7020

tggccggtat ttgatctgca ggtgggcttc gttgacggta tgccggcccg tttatggttg     7080

tgccttgata acctgttatt ggacgggctg agcatgcaga ttcttctctc tgaactggag     7140

catggatatc gctacccaca gcaactccct cccccgttgc cgatcacttt tcgcgattat     7200

cttcagcaac cggcactccg taccccaaat cctgactcat tggcttggtg gcagacgcaa     7260

ctggatgaca tcccacctgc gcccgccctc ccgctacgtt gtctgcctca agatgttgaa     7320

accccgcgtt tcgcgcgtct gtacggcgca atggattctg ctcgttggcg tcgcctgaaa     7380

cagcgtgcgg ccgacgcaca tctgactccg tcagctgtcc tactgagcgt atggtctaca     7440

gtgctggcag cttggtcggc gcagccggat tttactctca acctgacatt attcgaccgg     7500

cgaccactgc accctcagat taatcaaatc cttggcgatt ttacctcact gatgttattg     7560

tcgtggcatc cgggtgagag ttggctgcag tccgcgcgtc ttctccagca acgcctttca     7620

gaatcgctca accaccgtga tgttagcgcc attcgcgtca tgcggcagct ggcgagaagg     7680

caaaatgtcc cggccgtacc catgccggtc gtatttacct ctgcgctggg gtttgaacag     7740

gataacttcc tggcccgtcg caatctactg aaaccggtgt ggggtatcag tcagacgccg     7800

caagtttggc tggaccatca ggtctatgaa tccgagggcg aactgcgttt taactgggat     7860

ttcgttgcgg ccctgtttcc ggacggtcaa gtggaacgtc agttcgcgca atactgcgcc     7920

ttattgaatc gcatggcaga agatgacagc tcttggcagt tgccgcttgc tgatctggtg     7980

cccccgttaa aagtgaccga gcggcgagcg agaaggctgc gtccagaacg cgcccagcct     8040

cgtattgcag ctgataagag ttccgttagt ctgatctgtg acacttttcg tgaggtggtt     8100

ggggaacccg tggcaccggc tgagaacttt ttcgaagcgg gagccacatc cctcaatctg     8160

gttcagctgc atgtccttct ccaacgtcac gaatttgcga ccttaacgct actggatttg     8220

ttcacccatc caagccctgt tgcattggct aactatcttg cgggtgtggc cctggaagag     8280

aaaacgaagc gcgtgcggcc ggttcggcga agacagcgtc gcattcagca cttgccctta     8340

gtagctgcgc aacctggaat atggatggcc gagaagttat ctgaactacc atcagcgtgg     8400

agcgtagcgc attacgtgga gctcactggt gaggttgact cgcctctttt ggccagggcg     8460

gtagtggctg gccttgcaca agctgacacc ttaagaatgc gtttcacaga ggataatggg     8520

gaagtttggc aatgggtaga cgatgcgtta acatttgagt taccggaaat catagacctg     8580

cgcactaaca tagaccctca cgggacagct caggccttga tgcaagcgga cctgcaacag     8640

gacctacgtg tggattcggg gaagcctctg gtcttccatc agctaattca agtagcggac     8700

aatcgctggt actggtatca aaggtaccac cacttgcttg tggacgggtt cagttttcca     8760

gcgataacca ggcaaatagc caacatttat tgcacttggt tgcgaggaga gcctacgccc     8820

gcatccccct tcacgccatt cgcagacgtt gttgaggaat accaacagta tcgcgagagc     8880

gaagcgtggc aacgcgatgc ggcattctgg gcggagcaac gacggcaact accgcctccc     8940

gcatccctat cacctgcccc gctccccggc cggtccgcgt cagccgacat tctacggcta     9000

aagctggagt tcacagatgg tgaatttcga cagcttgcta cacaactcag cggggtacaa     9060

aggacagacc tagcgctcgc tctggctgca ttatggctag gacgactttg caatcgaatg     9120

gactacgcgg cgggtttcat atttatgcgc cggctcggca gcgcagcgtt gaccgcaacg     9180

ggtccagttt taaatgttct tcctttggga atccacatag gcaacccaag cttctctgag     9240

cttctcacca gggttcgcga ggtcgcctta ggcgcgtatg cacaccaaca tattcctttt     9300

gagatgttag tagaggcact gcaaccagag cgaaacctta gccatactcc tctcttccaa     9360

gtgatgtttg tccttcagaa tgcgcccgcg tcccaattag agttaaccgg gatcaccgca     9420

aacccaatta aggttaaatc aactaccacg aagttcgacc taactttaat catgcaaaac     9480

acagctagcg gattagtagg tgtttgggag tacaacacgg atttattcga cgcgtcaacg     9540

attgagcgaa tgacagggca ctttgtaacc ctcctcgagg gcgttatcgc caatccacaa     9600

cagccgatct ctcaacttcc tattttaact acagtggagc aacagcaact tttagtcgag     9660

tggaataaca cgcaaaccga ctaccccgct gataagtgta tacatcaatt attcgaggaa     9720

caggtcgagc gcacaccaga cgccgttgct gtcgtctttg ggaatcagca actcagctat     9780

cgagagatgc gcgaacaagt ggttgcactc gccaatttat tacgtgagcg gggagtcaag     9840

ccaggagact ccgttgccgt ggccttacca cgctctgttt tcttaaccct tgcactacac     9900

gcgattgtcg aggcaggtgc cgcctggcta cctcttgaca caggatatcc tgacgataga     9960

ttaaaaatga tgctcgagga tgcacggcct tcccttctga tcacaacaga cgatcaatta    10020

ccccgcttca gtgacgtacc taatctgacc tcactctgtt acaacgctcc cttgacgcct    10080

caagggagcg cccctttaca gctgtctcaa cctcaccata ctgcatatat catctttaca    10140

agtggttcta cgggacgccc caagggagta atggttggtc agactgcgat tgtaaatcgt    10200

ctgttgtgga tgcaaaacca ctaccctttg acgggggagg acgttgtagc ccaaaagact    10260

ccttgctcgt tcgatgtctc agtctgggag ttcttttggc catttatagc aggggccaaa    10320

ttagttatgg cggagccgga agcccaccga gacccacttg cgatgcagca attctttgct    10380

gagtatggtg tcaccactac acatttcgtc ccatcgatgt tagcggcctt cgtggcttct    10440

cttactccac aaacggctag gcaatcttgt gccacactaa agcaagtctt ctgctccggc    10500

gaggcattac ctgcagactt gtgccgggaa tggcagcaac tcacaggagc tccattgcac    10560

aatctatacg gaccgaccga ggccgcagta gacgtatctt ggtatcctgc gtttggcgag    10620

gagttagcgc aagtaagagg ttcgtcagta ccaataggat accccgtatg gaacacgggg    10680

cttcggatac tggacgcgat gatgcatccg gtcccaccag gagtcgcggg cgatttatac    10740

ctgactggga tacagctggc ccaaggttac ctagggagac ctgaccttac ggcgtcgagg    10800

ttcatagcgg atccgtttgc tccgggtgag cgcatgtacc gtacgggcga cgtcgcgcga    10860

tggctagata atggcgccgt agagtatctt ggtagatcag acgatcagtt aaagatacgg    10920

ggacaacgaa tagagcttgg ggaaatagac cgggtaatgc aggctttgcc agatgtcgag    10980

caagcggtgg cttcgtgtgc tattgcgcgg gaggacatac ctgggaacaa acaccttgta    11040

gcgtacatag ttcctcaaga ggagcaaaca tgcactgagc gatcgaggtc cacacttaca    11100

gtttcgttcg tccggagttt ccttaaggag aaactccccg aatatatggt accgagcgca    11160

atagtgattc tagacgctct ccccctgact cctaatggaa agctagaccg gcgggcgtta    11220

cccgcccctg acctgcactc acaacttgag acaattattg ctgcggcttt ctcgagcctg    11280

ctcgggtgcg acgtacaaga cgcggatgct gactttttcg cgctaggtgg ccattcgctg    11340

cttgccatga agctagccgc tcagctttcc cgacaagtag cgcggcaggt gacaccaggc    11400

caagttatgg tagcttcgac tgtcgcaaag ctcgcaacga tcatagacgc ggagttagat    11460

aaatacgtcg ctccaaggaa cccgataaca tccggggaag ataaccctat ccccctatgt    11520

caaggcgatg gggaggagat gagcacatgg ctacgtcgtt ttggaccccc agtcgaacat    11580

cgggccaggc tagtgtgttt cccccacgca ggcgcagcgg cggattcata cttagaccta    11640

gcaagagcgt tagcaccaga gatcgatgtt catgctgttc aataccccgg caggcaagac    11700

agaagggacg aggagccatt aggaaccgca ggtgaaattg cagatgaagt ggcagcggtg    11760

ctacgtgcgt cgggagggga tgggcctttt gcacttttcg gccacagtat gggcgccctc    11820

atcgcgtacg agacagcaag gcgattagag agggaaccgg gagggggacc cttacgttta    11880

ttcgtgagcg gacaaacagc gccacgtgtc catgaacgaa gaactgatct gcccggtgac    11940

gatggactcg tggacgagct taggcgactt ggcacctccg aggcagcgct cgcagacgaa    12000

gccctgctgg ctatgtctct cccggtgctc agggcggatt atagggtgtt aagatcctac    12060

gcttgggcgg atggtccccc actacgcgcc ggtataactg ccctctgcgg tgatgcagac    12120

ccactaactg caacagggga tgcggaacgc tggttacaac attccgtgat tccgggtcgg    12180

acacggacat ttcccggtgg gcatttttat ttaggggaac aagtgaccga ggtggcaggg    12240

gctgtccgta gagatttact gagagcaggg ttagcgggtt ga                       12282


<210>  5
<211>  13581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IHC

<400>  5
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct actgccagta     7980

gaacagcctt ttgtgcactc accggaagag cggtatcgac cattcgcgtt aacggatgtt     8040

cagcaagcct acctggtcgg gcgccagccg ggatttgccc tgggcggtgt aggctcgcat     8100

ttcttcgtgg aattcgagat cgcagatctc gacatacacc gcctggaaaa agtgtggaac     8160

cgtttaattg cacgtcatga tatgttgcgc gctgtggttc gtgacggtca gcaacgtgta     8220

ctggaacaga ccccgccatg ggtcatacca gcacatattc ttcacagtcc tgaagaggca     8280

ttacaggttc gtgatcgttt agctcaccaa gtgttgaacc ccgaagtctg gccggtattt     8340

gatctgcagg tgggcttcgt tgacggtatg ccggcccgtt tatggttgtg ccttgataac     8400

ctgttattgg acgggctgag catgcagatt cttctctctg aactggagca tggatatcgc     8460

tacccacagc aactccctcc cccgttgccg atcacttttc gcgattatct tcagcaaccg     8520

gcactccgta ccccaaatcc tgactcattg gcttggtggc agacgcaact ggatgacatc     8580

ccacctgcgc ccgccctccc gctacgttgt ctgcctcaag atgttgaaac cccgcgtttc     8640

gcgcgtctgt acggcgcaat ggattctgct cgttggcgtc gcctgaaaca gcgtgcggcc     8700

gacgcacatc tgactccgtc agctgtccta ctgagcgtat ggtctacagt gctggcagct     8760

tggtcggcgc agccggattt tactctcaac ctgacattat tcgaccggcg accactgcac     8820

cctcagatta atcaaatcct tggcgatttt acctcactga tgttattgtc gtggcatccg     8880

ggtgagagtt ggctgcagtc cgcgcgtctt ctccagcaac gcctttcaga atcgctcaac     8940

caccgtgatg ttagcgccat tcgcgtcatg cggcagctgg cgagaaggca aaatgtcccg     9000

gccgtaccca tgccggtcgt atttacctct gcgctggggt ttgaacagga taacttcctg     9060

gcccgtcgca atctactgaa accggtgtgg ggtatcagtc agacgccgca agtttggctg     9120

gaccatcagg tctatgaatc cgagggcgaa ctgcgtttta actgggattt cgttgcggcc     9180

ctgtttccgg acggtcaagt ggaacgtcag ttcgcgcaat actgcgcctt attgaatcgc     9240

atggcagaag atgacagctc ttggcagttg ccgcttgctg atctggtgcc cccgttaaaa     9300

gtgaccgagc ggcgagcgag aaggctgcgt ccagaacgcg cccagcctcg tattgcagct     9360

gataagagtt ccgttagtct gatctgtgac acttttcgtg aggtggttgg ggaacccgtg     9420

gcaccggctg agaacttttt cgaagcggga gccacatccc tcaatctggt tcagctgcat     9480

gtccttctcc aacgtcacga atttgcgacc ttaacgctac tggatttgtt cacccatcca     9540

agccctgttg cattggctaa ctatcttgcg ggtgtggccc tggaagagaa aacgaagcgc     9600

gtgcggccgg ttcggcgaag acagcgtcgc attggagagc cgttcccact cgctcctatg     9660

caacacgcca tgtgggtagg gcggcacgac caccaacagc tcgggggagt agcaggccat     9720

ctttacgtcg agtttgacgg cgcgagagtc gaccccgatc ggttgcgcgc tgccgccacc     9780

cgactcgccc tacgtcaccc tatgttgagg gtacagttcc tgcctgacgg tacacaaagg     9840

atccctccag ccgcaggctc gcgggacttt cccatcagcg ttgcggatct tcgtcacgta     9900

gctcctgacg ttgtcgatca acggctcgcg ggtattagag acgcaaagtc tcatcaacag     9960

cttgatggag ctgtcttcga gttggctctc actctcctgc caggtgaaag gacgaggctg    10020

cacgtcgacc tggatatgca agctgctgac gccatgagct acaggatcct gctggcggac    10080

ttggccgcac tatacgacgg gagagagccc ccagcactcg gttacacgta tagagagtac    10140

cgccaggcta ttgaggccga ggaaacatta ccgcaacctg ttcgcgacgc cgatagggac    10200

tggtgggcac aaagaatacc acagcttcca gacccgcccg cactaccgac gcgtgccggt    10260

ggtgagagag atcgccggcg ctcgaccaga agatggcact ggttagaccc acaaacaagg    10320

gacgccctct tcgcacgagc acgagctcgt ggcatcacac ctgcaatgac acttgcggcc    10380

gcgtttgcaa atgtcctcgc gagatggtcc gcctcttccc ggttcttact caatttgccc    10440

cttttctcgc gccaagcgtt gcatccggac gtagacctct tggtaggtga cttcacatcg    10500

tcgctgctgt tagatgttga cctaggagat acagtgtcta atcttgctcg gaagaaccaa    10560

ctgactttta cggaggactg ggaacaccgg cattggagcg gagtagagtt gctgcgagaa    10620

ctcaaaaggc aacagcgtta cccacacgga gcgcccgtgg tgttcacttc taatcttggg    10680

cgcagtttat attcttctcg ggcggagtcc cccttgggag agcctgaatg gggaatttcg    10740

caaacaccac aggtttggat cgaccattta gcatttgagc accatgggga agtatggctc    10800

caatgggact cgaacgacgc cctcttccca cctgctttag tcgagactct gtttgacgcg    10860

tactgtcaat tgataaacca gctgtgcgac gatgaatccg catggcaaaa gcccttcgcg    10920

gacatgatgc cggcgagtca gcgtgctatt cgtgagcggg tgaacgctac cggcgcaccg    10980

atcccggagg gcctcttaca cgaagggatt tttcggatcg ctcttcaaca gcctcaggcg    11040

ctcgcggtaa cggacatgcg gtaccaatgg aatagttatc gagagatgcg ggaacaggtc    11100

gtcgctttgg caaatctact ccgagagcgc ggggtcaagc caggggactc agtcgctgta    11160

gcgcttcctc ggtcagtctt cctaaccttg gctctccacg cgatcgtaga ggcgggtgcg    11220

gcgtggcttc ccctcgacac gggctatccg gacgatcggt tgaagatgat gctagaggat    11280

gcacgaccct ctctgttaat cacaaccgac gatcaactcc ccaggttctc agacgtccct    11340

aatcttacca gtctatgtta caacgcgccc ctcactccac aaggcagcgc tcctttacaa    11400

cttagtcagc cgcaccatac cgcttatatc atttttacgt ccggttccac gggcaggccg    11460

aagggtgtaa tggtgggcca aactgcaata gtgaatagac tattgtggat gcaaaaccac    11520

tacccgctta ccggggagga cgtagtggct caaaagactc cctgctcttt cgatgtcagc    11580

gtgtgggagt tcttttggcc ttttatagcc ggcgctaaat tggttatggc ggagccggaa    11640

gctcaccgag accctttggc catgcaacag ttctttgcag agtatggagt cacaacgacg    11700

catttcgtcc catcgatgtt agccgcgttc gtagcatcat tgacgccaca aactgcgaga    11760

cagtcatgtg ccacacttaa gcaagtcttc tgctctggtg aggcccttcc tgcggaccta    11820

tgtcgggaat ggcaacagct tactggagcc cccttgcaca atctttacgg gccgactgag    11880

gccgcagttg acgtatcgtg gtatccagcg ttcggggagg agctagccca agtgcgaggg    11940

tctagtgttc caattggata cccggtgtgg aacacagggt taaggatcct cgacgccatg    12000

atgcatccgg taccaccagg tgtcgctggg gatttgtacc tgactggcat tcaactggca    12060

cagggttatc tagggcggcc tgacttaaca gctagccgat tcatagcaga tccattcgct    12120

cccggagagc ggatgtaccg aacaggcgac gtggcacgct ggttagataa tggcgctgtc    12180

gagtatcttg ggcggtcaga cgatcagtta aagatacgtg gacaacggat tgagcttggt    12240

gaaatagacc gagttatgca ggcactacca gatgtcgagc aagccgtagc ctcttgtgcc    12300

attgcgcgag aagacattcc cgggaacaag cacttggttg cgtacatagt gccgcaagag    12360

gagcagacct gcacagagcg gtcacgttca actctcacag tttccttcgt ccgttctttc    12420

ttaaaggaga aactaccaga atatatggta ccgtccgcga tcgtgatatt agacgctctg    12480

ccactcacgc caaatggaaa gttggataga agagctctgc ctgctcctga cttgcactcg    12540

caactcctgg ataaatacgt tgctcccaga aacccaatag agactattat cgcggcagca    12600

ttctcttcat tgcttggatg cgacgtccaa gatgcggacg cagatttctt tgcgctcggg    12660

ggccatagtc tattggccat gaagctcgca gcgcaattgt cgagacaggt agcacggcaa    12720

gtaacgcccg ggcaagtcat ggtcgcctcg acagtcgcga aactcgcgac cattatcgac    12780

gctgagacat ccggggaaga taaccctatc cccctatgtc aaggcgatgg ggaggagatg    12840

agcacatggc tacgtcgttt tggaccccca gtcgaacatc gggccaggct agtgtgtttc    12900

ccccacgcag gcgcagcggc ggattcatac ttagacctag caagagcgtt agcaccagag    12960

atcgatgttc atgctgttca ataccccggc aggcaagaca gaagggacga ggagccatta    13020

ggaaccgcag gtgaaattgc agatgaagtg gcagcggtgc tacgtgcgtc gggaggggat    13080

gggccttttg cacttttcgg ccacagtatg ggcgccctca tcgcgtacga gacagcaagg    13140

cgattagaga gggaaccggg agggggaccc ttacgtttat tcgtgagcgg acaaacagcg    13200

ccacgtgtcc atgaacgaag aactgatctg cccggtgacg atggactcgt ggacgagctt    13260

aggcgacttg gcacctccga ggcagcgctc gcagacgaag ccctgctggc tatgtctctc    13320

ccggtgctca gggcggatta tagggtgtta agatcctacg cttgggcgga tggtccccca    13380

ctacgcgccg gtataactgc cctctgcggt gatgcagacc cactaactgc aacaggggat    13440

gcggaacgct ggttacaaca ttccgtgatt ccgggtcgga cacggacatt tcccggtggg    13500

catttttatt taggggaaca agtgaccgag gtggcagggg ctgtccgtag agatttactg    13560

agagcagggt tagcgggttg a                                              13581


<210>  6
<211>  14904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IHH

<400>  6
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct acctggaatt     7980

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     8040

atagtatcca tggcttgccg gttacccggt ggtgtgaata ccccacagag actatgggaa     8100

ttattacgtg aagggggaga aaccctcagt ggcttcccta ccgaccgagg gtgggacctc     8160

gcgaggttgc atcacccaga cccagacaac cccggtacgt catacgttga taaaggggga     8220

ttcctggacg atgcggcagg gtttgacgca gaatttttcg gtgtgagccc cagagaagca     8280

gcggctatgg acccgcagca gagattactc ctcgaaacca gctgggagtt agtcgagaat     8340

gcagggattg atccacatag cctaaggggg accgccactg gtgtcttcct cggcgttgcc     8400

aagtttgggt atggcgagga tacggcagct gccgaagacg tcgaggggta ctctgtcact     8460

ggtgtagccc cggcagtggc gtcgggcaga attagttaca cgatggggtt ggaagggccg     8520

tctatttcgg ttgataccgc ctgttcctcc agtctggttg cactccacct tgcagtcgag     8580

tcgctccgga aaggagaaag cagtatggcc gtggtcgggg gagcggcggt gatggccaca     8640

ccgggtgtgt ttgtggattt ttcccgacag agagccttgg ccgcggatgg gcgttcaaag     8700

gcgttcggag caggtgcaga cgggtttgga tttagcgaag gtgtgacact ggttctccta     8760

gaaagattaa gtgaagcccg gcgtaacggc catgaggtgc tggcagttgt tagaggttcc     8820

gcattaaacc aggacggggc ttcgaacggg ctgagcgccc cctcgggccc ggcacagaga     8880

agagtgatac gccaagcact cgaatcgtgt ggcctagaac caggtgacgt tgacgcggtg     8940

gaagcgcacg ggacaggaac tgcgttaggg gacccgatag aagcaaacgc cttgctggac     9000

acttatggta gagatcgtga tgcggatcga cccctctggt taggaagtgt taagtcaaat     9060

ataggacaca ctcaggcagc ggcgggagta actgggctgc tcaaagtagt cctagcctta     9120

cgcaatgggg aactacccgc caccctacat gtcgaggaac cgacaccgca tgtggattgg     9180

tcgagcgggg gagttgctct cttggcgggt aatcagccgt ggcgaagagg tgaacgaacc     9240

cgtagagccg ccgtgtccgc attcgggatc agtggtacga acgcgcacgt gattgtggaa     9300

gaagctccac aagaggtgag accagcgccc ggtcaaggac tctcgcccgc ggtgtcaacc     9360

ttggtagtgg cgggtaaaac tatgcagcgt gtttcggcaa ccgccggtat gctcgcagat     9420

tggatggaag gcccaggtgc agatgtggcg ctggcggacg tggcgcacac gttaaatcat     9480

caccgttcac ggcaaccaaa gttcggtacg gtggtggcca gggaccggac acaggcaatc     9540

gccggactaa gagcgctggc ggcgggtcag cacgccccag gggttgttaa ccctgctgaa     9600

ggaagtccag gtccagggac ggtgttcgtg tttcctggcc aggggtccca gcgtgcaggc     9660

atgggggagg agttggctgc ggctttcccc gtgtttgcca gaatccacca gcaagtgtgg     9720

gatttactcg atgttcctga tctcgacgtt aacgaaacgg ggtacgcaca accagcactc     9780

ttcgcactcc aagtggcgct gtttgggctc ctcgaatcat ggggagtacg gccggatgcc     9840

gtggtcgggc atagtgtagg ggaattagcg gcagggtacg tttccgggct ttggagtctt     9900

gaggatgctt gcacgctcgt gtcggcgaga gcccgtctaa tgcaagcctt accggcaggt     9960

ggtgttatgg cggcagttcc agtgtccgaa gacgaagcac gggctgtgtt gggggaagga    10020

gtcgaaatag ctgcggtcaa cggtccgtcg agcgtggttc taagcggtga tgaagcagca    10080

gtgctccagg ccgcggaagg gttaggcaag tggacgcgat taccgacctc gcatgcattc    10140

cattctgctc gtatggaacc aatgctggaa gagtttagag cagtggcgga aggtctaaca    10200

tacaggactc cccaggtggc aatggccgcc ggagaccagg ttatgaccgc tgaatactgg    10260

gtgcgtcagg ttagggatac agttcgtttt ggcgagcaag ttgcctcgtt cgaggatgct    10320

gtattcgtgg aattgggagc agatcgctct cttgcacggc tagtcgatgg tatcgcgatg    10380

ttgcacgggg atcatgaggc acaggctggt atgcggagag aacaaccctt gcccttaggt    10440

ttacgaagat tgctaaccga cctgcataac gctggtgctg ccgtcgattt tagtgttttg    10500

tgcccacaag gtcgtctggt tgacgcaccg ttaccagcct ggtcacaccg gtttctcttc    10560

tatgaccggg aaggagtgga caatagatca ccagggggaa gcacagtggc ggtccacccg    10620

cttttactag ccgcggtgga tgtgccgggc cacggtggag cggttttcac gggtagactc    10680

tcgactgacg agcaaccgtg gttagcggag cacgttgtcg ggggaagaac cctagttcct    10740

ggttctgttt tagtcgatct agccttagcg gcaggcgaag acgtagggct accggtgtta    10800

gaagaattag tattgcagag gccgctggtg cttgccggcg cgggagcact cctacggatg    10860

tcggtcgggg caccagacga gagcggtaga agaactatcg atgttcacgc agctgaagac    10920

gtcgccgatt tagcagatgc ccaatggtcc cagcacgcca ccgggacttt agcccaaggg    10980

gtagcggcgg ggcccaggga cacagagcaa tggcccccag aggatgccgt ccggattcca    11040

ttagacgacc attatgatgg tctcgcggaa cagggttatg agtacggtcc gtcgtttcag    11100

gcgctagtgg cctacgtggc ggaggatgcg actgcgacaa tgttagcgga agtcgcgctt    11160

ccgggcagca ttagatcgca acaaggtcta tacgccatcc atcccgcact gctggacgct    11220

tgttttcaat ctgtcggagc ccacccagac agtcaatccg tcgggtcagg tctactcgta    11280

cccctcggtg ttcggagagt tcgtgcgtac gcacccgtaa ggaccgcccg ttattgttac    11340

acccgcgtca cgaaagttga actagctggg gttgaggccg acatcgacgt tctggatgct    11400

cacggcacag tgcttctagc cgtgtgcggt cttcgtatcg ggaccggagt gagcgagagg    11460

gacaaacaca acagagttct caatgagcgc ctactcacca tcgaatggca tcagcgtgaa    11520

ctaccagaaa tggacccctc gggtgccggg aagtggctcc taatctcgga ctgtgcagca    11580

tccgatgtca ccgctacacg actggctgat gccttccggg agcacagcgc tgcgtgcact    11640

accatgcggt ggccacttca cgatgatcaa ctagcagccg ccgaccaact ccgggaccag    11700

gtgggttcag atgagttttc tggcgtggta gtactaacag ggccaaacac agggacccct    11760

catcagggtt ccgcagaccg tggcgccgag tacgttaggc ggttagttgg aatcgctcgt    11820

gaacttagcg atcttcccgg agcggttccc cgtatgtatg tcgtcacaag gggagcgcag    11880

agagtccttg ccgatgattg tgttaattta gaacagggag ggctcagagg tctgctgagg    11940

accatcggtg ctgagcaccc acatctccgc gccacccaaa ttgatgttga tgagcagaca    12000

ggagtagagc agctggcgcg acaactccta gctacatcgg aggaagacga gacagcctgg    12060

agggacaacg aatggtacgt tgcgaggtta tgccccacac ccctgaggcc acaggaacgt    12120

aggacaatag tggcggacca tcaacagtct ggtatgcggt tacaaatacg tacgcccggt    12180

gcaatcgata gtgtggcctt tgaacccgca cccgatgtag agcaaccctt acgggcgggt    12240

gaagttcggg ttgacgttag agcaaccggt gttaatttcc gtgacgttct actcgctctc    12300

gggatgtatc cccagaaagc tgacatgggg acagaagcag ctggtgttgt aacagcagtg    12360

ggacctgatg tcgatgcgtt tgcgcctggt gatagagttc tagggctatt ccaaggggca    12420

tttgctccaa ttgcggtgac tgaccatcgt ttactggcac gggtgccaga cgggtggtca    12480

gatgccgatg cggcggcggt gccaatagct tacacgacag cacattatgc gctgcacgac    12540

ctggcggggt tgcgggcggg gcaatctgtc ctgatacacg cggcagcggg tggtgttggt    12600

atggccgctg ttgcactggc acggagggcc ggcgcagaag ttctggctac cgcaggacct    12660

gcaaaacacg gtacgctacg ggcattaggg ctagatgatg aacacatcgc ttcgagtcgg    12720

gagaccgggt tcgcgcgtaa gttccgagag cggactgggg gacgaggagt ggacgtcgtt    12780

ctaaacagct tgaccggcga actattagac gagtccgcgg atctcctcgc ggaggacgga    12840

gtcttcgtgg aaatgggaaa gactgatctg cgcgatgcag gggactttcg tgggcgctac    12900

gccccgtttg atctagggga agcaggcgat gacaggctcg gggaaattct acgtgaggtg    12960

gtgggactgc tcggtgcagg ggaactcgac cgactccctg ttagcgcgtg ggaattgggg    13020

ataccccaga cggggaagtc gttagtgacg ctgccacccg aacaagcgca agttttcaga    13080

ccagacggca ctgtattgat caccggggga acgggaacgt taggtcggct gctggcccgt    13140

catctggtta cagagcacgg ggtgcgtcac ctgctgctag tgtcgaggag aggagcagat    13200

gcccctggat cggacgagct gagggccgaa atcgaggatc tcggagcatc agcggaaatt    13260

gcagcatgtg atacagccga tcgagacgct ctcagcgcgt tgctagatgg actgccgagg    13320

ccactgaccg gagtagttca cgccgcggga gtcctcgctg acggtctggt tacatccatc    13380

gacgagcccg cagtcgaaca agttctccgt gcaaaagttg atgcggcctg gaacctgcac    13440

gagctaactg cgaacaccgg tctcagcttt ttcgtgctgt tctcgtcagc cgcaagtgtg    13500

ttagcggggc cggggcaggg agtatatgcg gcagcgaacg aatctttaaa cgctctggcc    13560

gctctgcgta ggactagggg tttacccgca aaagcattgg gatggggatt atgggcgata    13620

gggcgtgcaa tagcatttgc cgagcagacc ggtgacgcaa tcgccccgga ggaaggcgcg    13680

tacgccttcg agacactact cagacataac agggcgtact cgggttacgc tcccgtgata    13740

gggtcaccat ggctgactgc gttcgcccaa cattcgccct ttgcggagaa gttccagtcc    13800

ctggggcaaa atagatccgg gacgtctaag tttctggcag aattagtcga tctgccaaga    13860

gaagaatggc cagatcggtt acgtcgtcta ttagaactgg tgaggtctca tgctgccgca    13920

gtttcggggt atggatcggc agaccaatta ccagaaagaa aagcattcaa agacctcgga    13980

ttcgattcac tggcagcagt cgaactaaga aatcgtctag ggaccgcgac aggcgtccgg    14040

ctgcccagta ctctggtgtt cgaccaccca accccacttg cggttgcgga acatctacgt    14100

gatcgtctaa catccgggga agataaccct atccccctat gtcaaggcga tggggaggag    14160

atgagcacat ggctacgtcg ttttggaccc ccagtcgaac atcgggccag gctagtgtgt    14220

ttcccccacg caggcgcagc ggcggattca tacttagacc tagcaagagc gttagcacca    14280

gagatcgatg ttcatgctgt tcaatacccc ggcaggcaag acagaaggga cgaggagcca    14340

ttaggaaccg caggtgaaat tgcagatgaa gtggcagcgg tgctacgtgc gtcgggaggg    14400

gatgggcctt ttgcactttt cggccacagt atgggcgccc tcatcgcgta cgagacagca    14460

aggcgattag agagggaacc gggaggggga cccttacgtt tattcgtgag cggacaaaca    14520

gcgccacgtg tccatgaacg aagaactgat ctgcccggtg acgatggact cgtggacgag    14580

cttaggcgac ttggcacctc cgaggcagcg ctcgcagacg aagccctgct ggctatgtct    14640

ctcccggtgc tcagggcgga ttatagggtg ttaagatcct acgcttgggc ggatggtccc    14700

ccactacgcg ccggtataac tgccctctgc ggtgatgcag acccactaac tgcaacaggg    14760

gatgcggaac gctggttaca acattccgtg attccgggtc ggacacggac atttcccggt    14820

gggcattttt atttagggga acaagtgacc gaggtggcag gggctgtccg tagagattta    14880

ctgagagcag ggttagcggg ttga                                           14904


<210>  7
<211>  13251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IHO

<400>  7
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct acctggaatt     7980

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     8040

atcgtttcga tggcatgtcg tttaccggga ggagtcaata cgccccaacg gctctgggaa     8100

ttactacggg agggtggtga aaccttgtcc gggttcccaa cggaccgtgg ctgggaccta     8160

gcacggcttc accaccctga tccggacaac cccggaacga gctacgttga taagggtgga     8220

tttctcgacg acgcggcggg tttcgacgca gagtttttcg gggtttcacc aagggaagct     8280

gccgctatgg accctcagca acgattactt ttagagacct cgtgggagct agttgaaaat     8340

gcgggcatag atccacatag cctgcgaggg acagcgacag gggtgttcct aggagttgcg     8400

aagtttggtt atggtgagga cacagcagca gcggaagatg ttgaaggtta ttcagttacc     8460

ggtgttgctc ccgctgtggc atctggccgc atatcctaca ctatgggttt agaaggtcct     8520

tccatctcgg tcgataccgc atgctcaagc tcgctagtcg cgcttcatct agccgtagag     8580

tccctccgaa agggtgagtc atctatggcg gtggtgggtg gtgcagccgt tatggcgact     8640

cctggggtat ttgttgattt ttcacgccaa cgggcgcttg ccgcagacgg ccgttccaaa     8700

gcgttcgggg caggtgcaga tggttttggt ttcagcgagg gagtcacgct ggttctacta     8760

gagcgtttaa gtgaggcgcg tcgtaacggt catgaagttc tagctgtagt gcgcgggtcc     8820

gcgttaaacc aggacggagc gagcaacgga ctttcagcac cctccggccc tgcgcaacgt     8880

agagtaataa ggcaagcgct cgaatcgtgt gggcttgaac cgggggatgt tgacgcggtt     8940

gaggcgcatg gtactggtac agcactaggt gacccaatag aggccaatgc gctgttggac     9000

acttacgggc gagaccgtga tgcggatcgt ccactttggt tggggtccgt taagagcaat     9060

attgggcaca ctcaagctgc ggccggggtt acaggactgc tgaaggttgt gttagcactg     9120

cgcaatggtg agctacctgc aacgttacat gtcgaggaac caactccaca cgtcgattgg     9180

tcctcaggtg gtgtcgcatt actggcgggt aatcaaccat ggcgaagggg agaaaggacc     9240

agaagggcgg cagtgagcgc ctttggtatc tccggtacaa atgctcacgt gatagtggaa     9300

gaggcgcctc aggaagttcg acccgcccct ggccaagggc tgtcgccagc cgtgtccacg     9360

ttagttgttg caggtaaaac catgcagcgt gtaagtgcga cagctggaat gcttgcagac     9420

tggatggagg gtcctggggc cgatgttgca ttggcggatg tggcccatac cctgaaccat     9480

caccgatcaa gacagcccaa gttcgggacg gttgtagcgc gtgacaggac tcaggcgata     9540

gctgggctcc gtgcattggc ggctggtcaa catgctcctg gggtcgtcaa cccagctgaa     9600

ggttccccag gaccaggcac cgtgttcgtt tttcccggtc aaggttcgca gagggcaggg     9660

atgggggagg aactcgcggc agcctttcct gtcttcgctc gaatacatca gcaagtttgg     9720

gacctcctag atgttcccga cctcgacgtt aatgaaaccg ggtacgccca accagcgctg     9780

ttcgcgcttc aggtcgcgct ctttggcctt ctggagtcgt ggggtgttag gccagatgca     9840

gtggtagggc actcagttgg tgagctggcc gcggggtacg tgtccggtct ttggtcacta     9900

gaggacgcct gcacactagt ctcagcaaga gcgcgcctaa tgcaggcact gcctgctgga     9960

ggggtgatgg cggcagtccc cgtctccgag gatgaggcgc gggccgtcct gggcgaggga    10020

gttgaaattg cggctgtgaa tggaccctcg tccgttgtgc tctcagggga cgaggcggca    10080

gtcttacagg ccgccgaagg tctaggtaag tggacgcgac tgccgaccag ccatgctttt    10140

cactcagcga gaatggaacc catgctagaa gagtttcggg ccgtagcaga gggtctgacc    10200

tatcgtaccc ctcaagtagc tatggctgct ggggatcagg tgatgacagc agaatattgg    10260

gtgcggcagg ttcgggacac agttcgcttc ggggagcaag tagcgtcatt cgaggatgcg    10320

gtgtttgttg agttaggcgc tgacagaagt ctagcgcgtt tggtggacgg catcgccatg    10380

ctgcacggtg accacgaagc gcaggccgcg gaccataggc aaatcaccga agcggttgcg    10440

gatgcttacg tcttaggcca ccttccggat tttgcggcgc tgcggcggcc tcacgcacga    10500

aagttggact taccaactta tcccttcgag cgtagacagt actggttcag agatgcgcgt    10560

gagaggccgg aacaacccag agataccggc ggacctcgca cagaagcagt ccgtctgtta    10620

gaggatggta ggattgaaga attagctgca cttttgggag gggccagtga tgaccaacac    10680

acattacagg tgctgactaa gttggcggcg caacataacc aacaacgaac aacccggtca    10740

atcgctgacg acaggtacga aataaggtgg gaccgatcga cttccccact atccggagca    10800

gatgttgacc aagcggggag ctggatcgtg gtgtcagatg acgcagatgc cgttcccccg    10860

ctagtggact tgctggctgc acgtaacgag ccccatcagg ttgttggtct acccgcttcg    10920

gacgcagacg aggagaggct cgcagagact ctgcgtgcgg ctgcgactga agatgctacc    10980

cttcggatag tccacgttgc ggcgctcgaa gcaggcgcta cccccagcat gcgttcactg    11040

ctccgcatgc agcaccgaat actaggtggc acgcggcggg tgttcagggc agcggtcgca    11100

gcggagttaa gaggtcccat ttggatagtg acgcggggag cacaaagagt ggctgacacc    11160

gatacagttg ccccgcatca gtcatgcctc tggggatttg ggagggcagc atcgctggag    11220

ctgccgcacg tttggggtgg cctagcagat ttatcagagg gcggtgacaa tgcggccgat    11280

gagtggagtg cgctagtgga ccgcattgcc gcaccccacg gttcagcagt tagggaggac    11340

caactggcgc tgagagacag ggccgtatat acgccaagac tggccagacg ttctgcgccc    11400

ccgagcggga ctcccctaca tctacgaggg gatggcacag tgttaataac aggtgggact    11460

ggtacactag gtaggctatt agcgcgtcac ctagtaacag agcatggggt gcggcatctc    11520

ttactagttt caaggagagg cgccgatgcc cctggctcgg atgaactgcg cgcagaaata    11580

gaggacttag gtgccagcgc ggagatcgca gcgtgtgata cagcggatcg cgatgcccta    11640

tctgccctac tagatggtct cccccggccc cttacgggtg tcgttcacgc cgctggcgtg    11700

ttagccgatg gacttgtcac tagcattgac gagcctgcgg tggaacaggt tctccgagca    11760

aaggtggacg cggcatggaa cctacacgaa ctcacagcta ataccgggct atcctttttc    11820

gttcttttct catcagcagc atcggtcctg gcaggtccag ggcaaggagt ttatgcggct    11880

gcaaatgaat cgctcaacgc actagctgcg ttaaggcgaa ctaggggtct gccggccaag    11940

gctctgggat ggggcctgtg ggccatcggg cgggcaatcg cttttgcgga gcagaccggg    12000

gacgccatcg ctccagagga aggagcatac gcttttgaaa ctctgttaag gcataaccgt    12060

gcctactcgg gatatgcgcc cgtcattgga tctccctggt tgaccgcgtt cgcacagcat    12120

tccccctttg cagaaaaatt ccaatcactc ggacagaatc ggtcagggac atcgaaattc    12180

ttagcggagc tagttgacct gcctcgtgag gaatggccgg ataggctcag gagactacta    12240

gagttagtta ggtcccatgc cgccgcggtc tccggttacg gtagtgcaga tcaactgccg    12300

gaaagaaaag cgttcaagga tttggggttt gattcgctgg ccgccgttga actgcgtaac    12360

cggctgggaa cggctacagg ggtacgactg ccgtcaaccc tagtatttga tcacccaact    12420

ccgctggccg tcgctgagca cttaagagat aggctaacat ccggggaaga taaccctatc    12480

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    12540

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    12600

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    12660

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    12720

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    12780

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    12840

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    12900

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    12960

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    13020

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    13080

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    13140

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    13200

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             13251


<210>  8
<211>  13590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IHS

<400>  8
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct actgccagta     7980

gaacagcctt ttgtgcactc accggaagag cggtatcgac cattcgcgtt aacggatgtt     8040

cagcaagcct acctggtcgg gcgccagccg ggatttgccc tgggcggtgt aggctcgcat     8100

ttcttcgtgg aattcgagat cgcagatctc gacatacacc gcctggaaaa agtgtggaac     8160

cgtttaattg cacgtcatga tatgttgcgc gctgtggttc gtgacggtca gcaacgtgta     8220

ctggaacaga ccccgccatg ggtcatacca gcacatattc ttcacagtcc tgaagaggca     8280

ttacaggttc gtgatcgttt agctcaccaa gtgttgaacc ccgaagtctg gccggtattt     8340

gatctgcagg tgggcttcgt tgacggtatg ccggcccgtt tatggttgtg ccttgataac     8400

ctgttattgg acgggctgag catgcagatt cttctctctg aactggagca tggatatcgc     8460

tacccacagc aactccctcc cccgttgccg atcacttttc gcgattatct tcagcaaccg     8520

gcactccgta ccccaaatcc tgactcattg gcttggtggc agacgcaact ggatgacatc     8580

ccacctgcgc ccgccctccc gctacgttgt ctgcctcaag atgttgaaac cccgcgtttc     8640

gcgcgtctgt acggcgcaat ggattctgct cgttggcgtc gcctgaaaca gcgtgcggcc     8700

gacgcacatc tgactccgtc agctgtccta ctgagcgtat ggtctacagt gctggcagct     8760

tggtcggcgc agccggattt tactctcaac ctgacattat tcgaccggcg accactgcac     8820

cctcagatta atcaaatcct tggcgatttt acctcactga tgttattgtc gtggcatccg     8880

ggtgagagtt ggctgcagtc cgcgcgtctt ctccagcaac gcctttcaga atcgctcaac     8940

caccgtgatg ttagcgccat tcgcgtcatg cggcagctgg cgagaaggca aaatgtcccg     9000

gccgtaccca tgccggtcgt atttacctct gcgctggggt ttgaacagga taacttcctg     9060

gcccgtcgca atctactgaa accggtgtgg ggtatcagtc agacgccgca agtttggctg     9120

gaccatcagg tctatgaatc cgagggcgaa ctgcgtttta actgggattt cgttgcggcc     9180

ctgtttccgg acggtcaagt ggaacgtcag ttcgcgcaat actgcgcctt attgaatcgc     9240

atggcagaag atgacagctc ttggcagttg ccgcttgctg atctggtgcc cccgttaaaa     9300

gtgaccgagc ggcgagcgag aaggctgcgt ccagaacgcg cccagcctcg tattgcagct     9360

gataagagtt ccgttagtct gatctgtgac acttttcgtg aggtggttgg ggaacccgtg     9420

gcaccggctg agaacttttt cgaagcggga gccacatccc tcaatctggt tcagctgcat     9480

gtccttctcc aacgtcacga atttgcgacc ttaacgctac tggatttgtt cacccatcca     9540

agccctgttg cattggctaa ctatcttgcg ggtgtggccc tggaagagaa aacgaagcgc     9600

gtgcggccgg ttcggcgaag acagcgtcgc attcagcact tgcccttagt agctgcgcaa     9660

cctggaatat ggatggccga gaagttatct gaactaccat cagcgtggag cgtagcgcat     9720

tacgtggagc tcactggtga ggttgactcg cctcttttgg ccagggcggt agtggctggc     9780

cttgcacaag ctgacacctt aagaatgcgt ttcacagagg ataatgggga agtttggcaa     9840

tgggtagacg atgcgttaac atttgagtta ccggaaatca tagacctgcg cactaacata     9900

gaccctcacg ggacagctca ggccttgatg caagcggacc tgcaacagga cctacgtgtg     9960

gattcgggga agcctctggt cttccatcag ctaattcaag tagcggacaa tcgctggtac    10020

tggtatcaaa ggtaccacca cttgcttgtg gacgggttca gttttccagc gataaccagg    10080

caaatagcca acatttattg cacttggttg cgaggagagc ctacgcccgc atcccccttc    10140

acgccattcg cagacgttgt tgaggaatac caacagtatc gcgagagcga agcgtggcaa    10200

cgcgatgcgg cattctgggc ggagcaacga cggcaactac cgcctcccgc atccctatca    10260

cctgccccgc tccccggccg gtccgcgtca gccgacattc tacggctaaa gctggagttc    10320

acagatggtg aatttcgaca gcttgctaca caactcagcg gggtacaaag gacagaccta    10380

gcgctcgctc tggctgcatt atggctagga cgactttgca atcgaatgga ctacgcggcg    10440

ggtttcatat ttatgcgccg gctcggcagc gcagcgttga ccgcaacggg tccagtttta    10500

aatgttcttc ctttgggaat ccacataggc aacccaagct tctctgagct tctcaccagg    10560

gttcgcgagg tcgccttagg cgcgtatgca caccaacata ttccttttga gatgttagta    10620

gaggcactgc aaccagagcg aaaccttagc catactcctc tcttccaagt gatgtttgtc    10680

cttcagaatg cgcccgcgtc ccaattagag ttaaccggga tcaccgcaaa cccaattaag    10740

gttaaatcaa ctaccacgaa gttcgaccta actttaatca tgcaaaacac agctagcgga    10800

ttagtaggtg tttgggagta caacacggat ttattcgacg cgtcaacgat tgagcgaatg    10860

acagggcact ttgtaaccct cctcgagggc gttatcgcca atccacaaca gccgatctct    10920

caacttccta ttttaactac agtggagcaa cagcaacttt tagtcgagtg gaataacacg    10980

caaaccgact accccgctga taagtgtata catcaattat tcgaggaaca ggtcgagcgc    11040

acaccagacg ccgttgctgt cgtctttggg aatcagcaac tcagctatcg agagatgcgc    11100

gaacaagtgg ttgcactcgc caatttatta cgtgagcggg gagtcaagcc aggagactcc    11160

gttgccgtgg ccttaccacg ctctgttttc ttaacccttg cactacacgc gattgtcgag    11220

gcaggtgccg cctggctacc tcttgacaca ggatatcctg acgatagatt aaaaatgatg    11280

ctcgaggatg cacggccttc ccttctgatc acaacagacg atcaattacc ccgcttcagt    11340

gacgtaccta atctgacctc actctgttac aacgctccct tgacgcctca agggagcgcc    11400

cctttacagc tgtctcaacc tcaccatact gcatatatca tctttacaag tggttctacg    11460

ggacgcccca agggagtaat ggttggtcag actgcgattg taaatcgtct gttgtggatg    11520

caaaaccact accctttgac gggggaggac gttgtagccc aaaagactcc ttgctcgttc    11580

gatgtctcag tctgggagtt cttttggcca tttatagcag gggccaaatt agttatggcg    11640

gagccggaag cccaccgaga cccacttgcg atgcagcaat tctttgctga gtatggtgtc    11700

accactacac atttcgtccc atcgatgtta gcggccttcg tggcttctct tactccacaa    11760

acggctaggc aatcttgtgc cacactaaag caagtcttct gctccggcga ggcattacct    11820

gcagacttgt gccgggaatg gcagcaactc acaggagctc cattgcacaa tctatacgga    11880

ccgaccgagg ccgcagtaga cgtatcttgg tatcctgcgt ttggcgagga gttagcgcaa    11940

gtaagaggtt cgtcagtacc aataggatac cccgtatgga acacggggct tcggatactg    12000

gacgcgatga tgcatccggt cccaccagga gtcgcgggcg atttatacct gactgggata    12060

cagctggccc aaggttacct agggagacct gaccttacgg cgtcgaggtt catagcggat    12120

ccgtttgctc cgggtgagcg catgtaccgt acgggcgacg tcgcgcgatg gctagataat    12180

ggcgccgtag agtatcttgg tagatcagac gatcagttaa agatacgggg acaacgaata    12240

gagcttgggg aaatagaccg ggtaatgcag gctttgccag atgtcgagca agcggtggct    12300

tcgtgtgcta ttgcgcggga ggacatacct gggaacaaac accttgtagc gtacatagtt    12360

cctcaagagg agcaaacatg cactgagcga tcgaggtcca cacttacagt ttcgttcgtc    12420

cggagtttcc ttaaggagaa actccccgaa tatatggtac cgagcgcaat agtgattcta    12480

gacgctctcc ccctgactcc taatggaaag ctagaccggc gggcgttacc cgcccctgac    12540

ctgcactcac aacttgagac aattattgct gcggctttct cgagcctgct cgggtgcgac    12600

gtacaagacg cggatgctga ctttttcgcg ctaggtggcc attcgctgct tgccatgaag    12660

ctagccgctc agctttcccg acaagtagcg cggcaggtga caccaggcca agttatggta    12720

gcttcgactg tcgcaaagct cgcaacgatc atagacgcgg agttagataa atacgtcgct    12780

ccaaggaacc cgataacatc cggggaagat aaccctatcc ccctatgtca aggcgatggg    12840

gaggagatga gcacatggct acgtcgtttt ggacccccag tcgaacatcg ggccaggcta    12900

gtgtgtttcc cccacgcagg cgcagcggcg gattcatact tagacctagc aagagcgtta    12960

gcaccagaga tcgatgttca tgctgttcaa taccccggca ggcaagacag aagggacgag    13020

gagccattag gaaccgcagg tgaaattgca gatgaagtgg cagcggtgct acgtgcgtcg    13080

ggaggggatg ggccttttgc acttttcggc cacagtatgg gcgccctcat cgcgtacgag    13140

acagcaaggc gattagagag ggaaccggga gggggaccct tacgtttatt cgtgagcgga    13200

caaacagcgc cacgtgtcca tgaacgaaga actgatctgc ccggtgacga tggactcgtg    13260

gacgagctta ggcgacttgg cacctccgag gcagcgctcg cagacgaagc cctgctggct    13320

atgtctctcc cggtgctcag ggcggattat agggtgttaa gatcctacgc ttgggcggat    13380

ggtcccccac tacgcgccgg tataactgcc ctctgcggtg atgcagaccc actaactgca    13440

acaggggatg cggaacgctg gttacaacat tccgtgattc cgggtcggac acggacattt    13500

cccggtgggc atttttattt aggggaacaa gtgaccgagg tggcaggggc tgtccgtaga    13560

gatttactga gagcagggtt agcgggttga                                     13590


<210>  9
<211>  11928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOC

<400>  9
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctact gccagtagaa cagccttttg tgcactcacc ggaagagcgg     6360

tatcgaccat tcgcgttaac ggatgttcag caagcctacc tggtcgggcg ccagccggga     6420

tttgccctgg gcggtgtagg ctcgcatttc ttcgtggaat tcgagatcgc agatctcgac     6480

atacaccgcc tggaaaaagt gtggaaccgt ttaattgcac gtcatgatat gttgcgcgct     6540

gtggttcgtg acggtcagca acgtgtactg gaacagaccc cgccatgggt cataccagca     6600

catattcttc acagtcctga agaggcatta caggttcgtg atcgtttagc tcaccaagtg     6660

ttgaaccccg aagtctggcc ggtatttgat ctgcaggtgg gcttcgttga cggtatgccg     6720

gcccgtttat ggttgtgcct tgataacctg ttattggacg ggctgagcat gcagattctt     6780

ctctctgaac tggagcatgg atatcgctac ccacagcaac tccctccccc gttgccgatc     6840

acttttcgcg attatcttca gcaaccggca ctccgtaccc caaatcctga ctcattggct     6900

tggtggcaga cgcaactgga tgacatccca cctgcgcccg ccctcccgct acgttgtctg     6960

cctcaagatg ttgaaacccc gcgtttcgcg cgtctgtacg gcgcaatgga ttctgctcgt     7020

tggcgtcgcc tgaaacagcg tgcggccgac gcacatctga ctccgtcagc tgtcctactg     7080

agcgtatggt ctacagtgct ggcagcttgg tcggcgcagc cggattttac tctcaacctg     7140

acattattcg accggcgacc actgcaccct cagattaatc aaatccttgg cgattttacc     7200

tcactgatgt tattgtcgtg gcatccgggt gagagttggc tgcagtccgc gcgtcttctc     7260

cagcaacgcc tttcagaatc gctcaaccac cgtgatgtta gcgccattcg cgtcatgcgg     7320

cagctggcga gaaggcaaaa tgtcccggcc gtacccatgc cggtcgtatt tacctctgcg     7380

ctggggtttg aacaggataa cttcctggcc cgtcgcaatc tactgaaacc ggtgtggggt     7440

atcagtcaga cgccgcaagt ttggctggac catcaggtct atgaatccga gggcgaactg     7500

cgttttaact gggatttcgt tgcggccctg tttccggacg gtcaagtgga acgtcagttc     7560

gcgcaatact gcgccttatt gaatcgcatg gcagaagatg acagctcttg gcagttgccg     7620

cttgctgatc tggtgccccc gttaaaagtg accgagcggc gagcgagaag gctgcgtcca     7680

gaacgcgccc agcctcgtat tgcagctgat aagagttccg ttagtctgat ctgtgacact     7740

tttcgtgagg tggttgggga acccgtggca ccggctgaga actttttcga agcgggagcc     7800

acatccctca atctggttca gctgcatgtc cttctccaac gtcacgaatt tgcgacctta     7860

acgctactgg atttgttcac ccatccaagc cctgttgcat tggctaacta tcttgcgggt     7920

gtggccctgg aagagaaaac gaagcgcgtg cggccggttc ggcgaagaca gcgtcgcatt     7980

ggagagccgt tcccactcgc tcctatgcaa cacgccatgt gggtagggcg gcacgaccac     8040

caacagctcg ggggagtagc aggccatctt tacgtcgagt ttgacggcgc gagagtcgac     8100

cccgatcggt tgcgcgctgc cgccacccga ctcgccctac gtcaccctat gttgagggta     8160

cagttcctgc ctgacggtac acaaaggatc cctccagccg caggctcgcg ggactttccc     8220

atcagcgttg cggatcttcg tcacgtagct cctgacgttg tcgatcaacg gctcgcgggt     8280

attagagacg caaagtctca tcaacagctt gatggagctg tcttcgagtt ggctctcact     8340

ctcctgccag gtgaaaggac gaggctgcac gtcgacctgg atatgcaagc tgctgacgcc     8400

atgagctaca ggatcctgct ggcggacttg gccgcactat acgacgggag agagccccca     8460

gcactcggtt acacgtatag agagtaccgc caggctattg aggccgagga aacattaccg     8520

caacctgttc gcgacgccga tagggactgg tgggcacaaa gaataccaca gcttccagac     8580

ccgcccgcac taccgacgcg tgccggtggt gagagagatc gccggcgctc gaccagaaga     8640

tggcactggt tagacccaca aacaagggac gccctcttcg cacgagcacg agctcgtggc     8700

atcacacctg caatgacact tgcggccgcg tttgcaaatg tcctcgcgag atggtccgcc     8760

tcttcccggt tcttactcaa tttgcccctt ttctcgcgcc aagcgttgca tccggacgta     8820

gacctcttgg taggtgactt cacatcgtcg ctgctgttag atgttgacct aggagataca     8880

gtgtctaatc ttgctcggaa gaaccaactg acttttacgg aggactggga acaccggcat     8940

tggagcggag tagagttgct gcgagaactc aaaaggcaac agcgttaccc acacggagcg     9000

cccgtggtgt tcacttctaa tcttgggcgc agtttatatt cttctcgggc ggagtccccc     9060

ttgggagagc ctgaatgggg aatttcgcaa acaccacagg tttggatcga ccatttagca     9120

tttgagcacc atggggaagt atggctccaa tgggactcga acgacgccct cttcccacct     9180

gctttagtcg agactctgtt tgacgcgtac tgtcaattga taaaccagct gtgcgacgat     9240

gaatccgcat ggcaaaagcc cttcgcggac atgatgccgg cgagtcagcg tgctattcgt     9300

gagcgggtga acgctaccgg cgcaccgatc ccggagggcc tcttacacga agggattttt     9360

cggatcgctc ttcaacagcc tcaggcgctc gcggtaacgg acatgcggta ccaatggaat     9420

agttatcgag agatgcggga acaggtcgtc gctttggcaa atctactccg agagcgcggg     9480

gtcaagccag gggactcagt cgctgtagcg cttcctcggt cagtcttcct aaccttggct     9540

ctccacgcga tcgtagaggc gggtgcggcg tggcttcccc tcgacacggg ctatccggac     9600

gatcggttga agatgatgct agaggatgca cgaccctctc tgttaatcac aaccgacgat     9660

caactcccca ggttctcaga cgtccctaat cttaccagtc tatgttacaa cgcgcccctc     9720

actccacaag gcagcgctcc tttacaactt agtcagccgc accataccgc ttatatcatt     9780

tttacgtccg gttccacggg caggccgaag ggtgtaatgg tgggccaaac tgcaatagtg     9840

aatagactat tgtggatgca aaaccactac ccgcttaccg gggaggacgt agtggctcaa     9900

aagactccct gctctttcga tgtcagcgtg tgggagttct tttggccttt tatagccggc     9960

gctaaattgg ttatggcgga gccggaagct caccgagacc ctttggccat gcaacagttc    10020

tttgcagagt atggagtcac aacgacgcat ttcgtcccat cgatgttagc cgcgttcgta    10080

gcatcattga cgccacaaac tgcgagacag tcatgtgcca cacttaagca agtcttctgc    10140

tctggtgagg cccttcctgc ggacctatgt cgggaatggc aacagcttac tggagccccc    10200

ttgcacaatc tttacgggcc gactgaggcc gcagttgacg tatcgtggta tccagcgttc    10260

ggggaggagc tagcccaagt gcgagggtct agtgttccaa ttggataccc ggtgtggaac    10320

acagggttaa ggatcctcga cgccatgatg catccggtac caccaggtgt cgctggggat    10380

ttgtacctga ctggcattca actggcacag ggttatctag ggcggcctga cttaacagct    10440

agccgattca tagcagatcc attcgctccc ggagagcgga tgtaccgaac aggcgacgtg    10500

gcacgctggt tagataatgg cgctgtcgag tatcttgggc ggtcagacga tcagttaaag    10560

atacgtggac aacggattga gcttggtgaa atagaccgag ttatgcaggc actaccagat    10620

gtcgagcaag ccgtagcctc ttgtgccatt gcgcgagaag acattcccgg gaacaagcac    10680

ttggttgcgt acatagtgcc gcaagaggag cagacctgca cagagcggtc acgttcaact    10740

ctcacagttt ccttcgtccg ttctttctta aaggagaaac taccagaata tatggtaccg    10800

tccgcgatcg tgatattaga cgctctgcca ctcacgccaa atggaaagtt ggatagaaga    10860

gctctgcctg ctcctgactt gcactcgcaa ctcctggata aatacgttgc tcccagaaac    10920

ccaatagaga ctattatcgc ggcagcattc tcttcattgc ttggatgcga cgtccaagat    10980

gcggacgcag atttctttgc gctcgggggc catagtctat tggccatgaa gctcgcagcg    11040

caattgtcga gacaggtagc acggcaagta acgcccgggc aagtcatggt cgcctcgaca    11100

gtcgcgaaac tcgcgaccat tatcgacgct gagacatccg gggaagataa ccctatcccc    11160

ctatgtcaag gcgatgggga ggagatgagc acatggctac gtcgttttgg acccccagtc    11220

gaacatcggg ccaggctagt gtgtttcccc cacgcaggcg cagcggcgga ttcatactta    11280

gacctagcaa gagcgttagc accagagatc gatgttcatg ctgttcaata ccccggcagg    11340

caagacagaa gggacgagga gccattagga accgcaggtg aaattgcaga tgaagtggca    11400

gcggtgctac gtgcgtcggg aggggatggg ccttttgcac ttttcggcca cagtatgggc    11460

gccctcatcg cgtacgagac agcaaggcga ttagagaggg aaccgggagg gggaccctta    11520

cgtttattcg tgagcggaca aacagcgcca cgtgtccatg aacgaagaac tgatctgccc    11580

ggtgacgatg gactcgtgga cgagcttagg cgacttggca cctccgaggc agcgctcgca    11640

gacgaagccc tgctggctat gtctctcccg gtgctcaggg cggattatag ggtgttaaga    11700

tcctacgctt gggcggatgg tcccccacta cgcgccggta taactgccct ctgcggtgat    11760

gcagacccac taactgcaac aggggatgcg gaacgctggt tacaacattc cgtgattccg    11820

ggtcggacac ggacatttcc cggtgggcat ttttatttag gggaacaagt gaccgaggtg    11880

gcaggggctg tccgtagaga tttactgaga gcagggttag cgggttga                 11928


<210>  10
<211>  13251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOH

<400>  10
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctacc tggaattggg gcgctagttc ccgctcccgt ggtaatcgca     6360

gcaggccgta cggaggaacc aattgccata gtatccatgg cttgccggtt acccggtggt     6420

gtgaataccc cacagagact atgggaatta ttacgtgaag ggggagaaac cctcagtggc     6480

ttccctaccg accgagggtg ggacctcgcg aggttgcatc acccagaccc agacaacccc     6540

ggtacgtcat acgttgataa agggggattc ctggacgatg cggcagggtt tgacgcagaa     6600

tttttcggtg tgagccccag agaagcagcg gctatggacc cgcagcagag attactcctc     6660

gaaaccagct gggagttagt cgagaatgca gggattgatc cacatagcct aagggggacc     6720

gccactggtg tcttcctcgg cgttgccaag tttgggtatg gcgaggatac ggcagctgcc     6780

gaagacgtcg aggggtactc tgtcactggt gtagccccgg cagtggcgtc gggcagaatt     6840

agttacacga tggggttgga agggccgtct atttcggttg ataccgcctg ttcctccagt     6900

ctggttgcac tccaccttgc agtcgagtcg ctccggaaag gagaaagcag tatggccgtg     6960

gtcgggggag cggcggtgat ggccacaccg ggtgtgtttg tggatttttc ccgacagaga     7020

gccttggccg cggatgggcg ttcaaaggcg ttcggagcag gtgcagacgg gtttggattt     7080

agcgaaggtg tgacactggt tctcctagaa agattaagtg aagcccggcg taacggccat     7140

gaggtgctgg cagttgttag aggttccgca ttaaaccagg acggggcttc gaacgggctg     7200

agcgccccct cgggcccggc acagagaaga gtgatacgcc aagcactcga atcgtgtggc     7260

ctagaaccag gtgacgttga cgcggtggaa gcgcacggga caggaactgc gttaggggac     7320

ccgatagaag caaacgcctt gctggacact tatggtagag atcgtgatgc ggatcgaccc     7380

ctctggttag gaagtgttaa gtcaaatata ggacacactc aggcagcggc gggagtaact     7440

gggctgctca aagtagtcct agccttacgc aatggggaac tacccgccac cctacatgtc     7500

gaggaaccga caccgcatgt ggattggtcg agcgggggag ttgctctctt ggcgggtaat     7560

cagccgtggc gaagaggtga acgaacccgt agagccgccg tgtccgcatt cgggatcagt     7620

ggtacgaacg cgcacgtgat tgtggaagaa gctccacaag aggtgagacc agcgcccggt     7680

caaggactct cgcccgcggt gtcaaccttg gtagtggcgg gtaaaactat gcagcgtgtt     7740

tcggcaaccg ccggtatgct cgcagattgg atggaaggcc caggtgcaga tgtggcgctg     7800

gcggacgtgg cgcacacgtt aaatcatcac cgttcacggc aaccaaagtt cggtacggtg     7860

gtggccaggg accggacaca ggcaatcgcc ggactaagag cgctggcggc gggtcagcac     7920

gccccagggg ttgttaaccc tgctgaagga agtccaggtc cagggacggt gttcgtgttt     7980

cctggccagg ggtcccagcg tgcaggcatg ggggaggagt tggctgcggc tttccccgtg     8040

tttgccagaa tccaccagca agtgtgggat ttactcgatg ttcctgatct cgacgttaac     8100

gaaacggggt acgcacaacc agcactcttc gcactccaag tggcgctgtt tgggctcctc     8160

gaatcatggg gagtacggcc ggatgccgtg gtcgggcata gtgtagggga attagcggca     8220

gggtacgttt ccgggctttg gagtcttgag gatgcttgca cgctcgtgtc ggcgagagcc     8280

cgtctaatgc aagccttacc ggcaggtggt gttatggcgg cagttccagt gtccgaagac     8340

gaagcacggg ctgtgttggg ggaaggagtc gaaatagctg cggtcaacgg tccgtcgagc     8400

gtggttctaa gcggtgatga agcagcagtg ctccaggccg cggaagggtt aggcaagtgg     8460

acgcgattac cgacctcgca tgcattccat tctgctcgta tggaaccaat gctggaagag     8520

tttagagcag tggcggaagg tctaacatac aggactcccc aggtggcaat ggccgccgga     8580

gaccaggtta tgaccgctga atactgggtg cgtcaggtta gggatacagt tcgttttggc     8640

gagcaagttg cctcgttcga ggatgctgta ttcgtggaat tgggagcaga tcgctctctt     8700

gcacggctag tcgatggtat cgcgatgttg cacggggatc atgaggcaca ggctggtatg     8760

cggagagaac aacccttgcc cttaggttta cgaagattgc taaccgacct gcataacgct     8820

ggtgctgccg tcgattttag tgttttgtgc ccacaaggtc gtctggttga cgcaccgtta     8880

ccagcctggt cacaccggtt tctcttctat gaccgggaag gagtggacaa tagatcacca     8940

gggggaagca cagtggcggt ccacccgctt ttactagccg cggtggatgt gccgggccac     9000

ggtggagcgg ttttcacggg tagactctcg actgacgagc aaccgtggtt agcggagcac     9060

gttgtcgggg gaagaaccct agttcctggt tctgttttag tcgatctagc cttagcggca     9120

ggcgaagacg tagggctacc ggtgttagaa gaattagtat tgcagaggcc gctggtgctt     9180

gccggcgcgg gagcactcct acggatgtcg gtcggggcac cagacgagag cggtagaaga     9240

actatcgatg ttcacgcagc tgaagacgtc gccgatttag cagatgccca atggtcccag     9300

cacgccaccg ggactttagc ccaaggggta gcggcggggc ccagggacac agagcaatgg     9360

cccccagagg atgccgtccg gattccatta gacgaccatt atgatggtct cgcggaacag     9420

ggttatgagt acggtccgtc gtttcaggcg ctagtggcct acgtggcgga ggatgcgact     9480

gcgacaatgt tagcggaagt cgcgcttccg ggcagcatta gatcgcaaca aggtctatac     9540

gccatccatc ccgcactgct ggacgcttgt tttcaatctg tcggagccca cccagacagt     9600

caatccgtcg ggtcaggtct actcgtaccc ctcggtgttc ggagagttcg tgcgtacgca     9660

cccgtaagga ccgcccgtta ttgttacacc cgcgtcacga aagttgaact agctggggtt     9720

gaggccgaca tcgacgttct ggatgctcac ggcacagtgc ttctagccgt gtgcggtctt     9780

cgtatcggga ccggagtgag cgagagggac aaacacaaca gagttctcaa tgagcgccta     9840

ctcaccatcg aatggcatca gcgtgaacta ccagaaatgg acccctcggg tgccgggaag     9900

tggctcctaa tctcggactg tgcagcatcc gatgtcaccg ctacacgact ggctgatgcc     9960

ttccgggagc acagcgctgc gtgcactacc atgcggtggc cacttcacga tgatcaacta    10020

gcagccgccg accaactccg ggaccaggtg ggttcagatg agttttctgg cgtggtagta    10080

ctaacagggc caaacacagg gacccctcat cagggttccg cagaccgtgg cgccgagtac    10140

gttaggcggt tagttggaat cgctcgtgaa cttagcgatc ttcccggagc ggttccccgt    10200

atgtatgtcg tcacaagggg agcgcagaga gtccttgccg atgattgtgt taatttagaa    10260

cagggagggc tcagaggtct gctgaggacc atcggtgctg agcacccaca tctccgcgcc    10320

acccaaattg atgttgatga gcagacagga gtagagcagc tggcgcgaca actcctagct    10380

acatcggagg aagacgagac agcctggagg gacaacgaat ggtacgttgc gaggttatgc    10440

cccacacccc tgaggccaca ggaacgtagg acaatagtgg cggaccatca acagtctggt    10500

atgcggttac aaatacgtac gcccggtgca atcgatagtg tggcctttga acccgcaccc    10560

gatgtagagc aacccttacg ggcgggtgaa gttcgggttg acgttagagc aaccggtgtt    10620

aatttccgtg acgttctact cgctctcggg atgtatcccc agaaagctga catggggaca    10680

gaagcagctg gtgttgtaac agcagtggga cctgatgtcg atgcgtttgc gcctggtgat    10740

agagttctag ggctattcca aggggcattt gctccaattg cggtgactga ccatcgttta    10800

ctggcacggg tgccagacgg gtggtcagat gccgatgcgg cggcggtgcc aatagcttac    10860

acgacagcac attatgcgct gcacgacctg gcggggttgc gggcggggca atctgtcctg    10920

atacacgcgg cagcgggtgg tgttggtatg gccgctgttg cactggcacg gagggccggc    10980

gcagaagttc tggctaccgc aggacctgca aaacacggta cgctacgggc attagggcta    11040

gatgatgaac acatcgcttc gagtcgggag accgggttcg cgcgtaagtt ccgagagcgg    11100

actgggggac gaggagtgga cgtcgttcta aacagcttga ccggcgaact attagacgag    11160

tccgcggatc tcctcgcgga ggacggagtc ttcgtggaaa tgggaaagac tgatctgcgc    11220

gatgcagggg actttcgtgg gcgctacgcc ccgtttgatc taggggaagc aggcgatgac    11280

aggctcgggg aaattctacg tgaggtggtg ggactgctcg gtgcagggga actcgaccga    11340

ctccctgtta gcgcgtggga attggggata ccccagacgg ggaagtcgtt agtgacgctg    11400

ccacccgaac aagcgcaagt tttcagacca gacggcactg tattgatcac cgggggaacg    11460

ggaacgttag gtcggctgct ggcccgtcat ctggttacag agcacggggt gcgtcacctg    11520

ctgctagtgt cgaggagagg agcagatgcc cctggatcgg acgagctgag ggccgaaatc    11580

gaggatctcg gagcatcagc ggaaattgca gcatgtgata cagccgatcg agacgctctc    11640

agcgcgttgc tagatggact gccgaggcca ctgaccggag tagttcacgc cgcgggagtc    11700

ctcgctgacg gtctggttac atccatcgac gagcccgcag tcgaacaagt tctccgtgca    11760

aaagttgatg cggcctggaa cctgcacgag ctaactgcga acaccggtct cagctttttc    11820

gtgctgttct cgtcagccgc aagtgtgtta gcggggccgg ggcagggagt atatgcggca    11880

gcgaacgaat ctttaaacgc tctggccgct ctgcgtagga ctaggggttt acccgcaaaa    11940

gcattgggat ggggattatg ggcgataggg cgtgcaatag catttgccga gcagaccggt    12000

gacgcaatcg ccccggagga aggcgcgtac gccttcgaga cactactcag acataacagg    12060

gcgtactcgg gttacgctcc cgtgataggg tcaccatggc tgactgcgtt cgcccaacat    12120

tcgccctttg cggagaagtt ccagtccctg gggcaaaata gatccgggac gtctaagttt    12180

ctggcagaat tagtcgatct gccaagagaa gaatggccag atcggttacg tcgtctatta    12240

gaactggtga ggtctcatgc tgccgcagtt tcggggtatg gatcggcaga ccaattacca    12300

gaaagaaaag cattcaaaga cctcggattc gattcactgg cagcagtcga actaagaaat    12360

cgtctaggga ccgcgacagg cgtccggctg cccagtactc tggtgttcga ccacccaacc    12420

ccacttgcgg ttgcggaaca tctacgtgat cgtctaacat ccggggaaga taaccctatc    12480

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    12540

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    12600

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    12660

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    12720

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    12780

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    12840

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    12900

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    12960

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    13020

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    13080

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    13140

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    13200

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             13251


<210>  11
<211>  11598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOO

<400>  11
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctacc tggaattggg gcgctagttc ccgctcccgt ggtaatcgca     6360

gcaggccgta cggaggaacc aattgccatc gtttcgatgg catgtcgttt accgggagga     6420

gtcaatacgc cccaacggct ctgggaatta ctacgggagg gtggtgaaac cttgtccggg     6480

ttcccaacgg accgtggctg ggacctagca cggcttcacc accctgatcc ggacaacccc     6540

ggaacgagct acgttgataa gggtggattt ctcgacgacg cggcgggttt cgacgcagag     6600

tttttcgggg tttcaccaag ggaagctgcc gctatggacc ctcagcaacg attactttta     6660

gagacctcgt gggagctagt tgaaaatgcg ggcatagatc cacatagcct gcgagggaca     6720

gcgacagggg tgttcctagg agttgcgaag tttggttatg gtgaggacac agcagcagcg     6780

gaagatgttg aaggttattc agttaccggt gttgctcccg ctgtggcatc tggccgcata     6840

tcctacacta tgggtttaga aggtccttcc atctcggtcg ataccgcatg ctcaagctcg     6900

ctagtcgcgc ttcatctagc cgtagagtcc ctccgaaagg gtgagtcatc tatggcggtg     6960

gtgggtggtg cagccgttat ggcgactcct ggggtatttg ttgatttttc acgccaacgg     7020

gcgcttgccg cagacggccg ttccaaagcg ttcggggcag gtgcagatgg ttttggtttc     7080

agcgagggag tcacgctggt tctactagag cgtttaagtg aggcgcgtcg taacggtcat     7140

gaagttctag ctgtagtgcg cgggtccgcg ttaaaccagg acggagcgag caacggactt     7200

tcagcaccct ccggccctgc gcaacgtaga gtaataaggc aagcgctcga atcgtgtggg     7260

cttgaaccgg gggatgttga cgcggttgag gcgcatggta ctggtacagc actaggtgac     7320

ccaatagagg ccaatgcgct gttggacact tacgggcgag accgtgatgc ggatcgtcca     7380

ctttggttgg ggtccgttaa gagcaatatt gggcacactc aagctgcggc cggggttaca     7440

ggactgctga aggttgtgtt agcactgcgc aatggtgagc tacctgcaac gttacatgtc     7500

gaggaaccaa ctccacacgt cgattggtcc tcaggtggtg tcgcattact ggcgggtaat     7560

caaccatggc gaaggggaga aaggaccaga agggcggcag tgagcgcctt tggtatctcc     7620

ggtacaaatg ctcacgtgat agtggaagag gcgcctcagg aagttcgacc cgcccctggc     7680

caagggctgt cgccagccgt gtccacgtta gttgttgcag gtaaaaccat gcagcgtgta     7740

agtgcgacag ctggaatgct tgcagactgg atggagggtc ctggggccga tgttgcattg     7800

gcggatgtgg cccataccct gaaccatcac cgatcaagac agcccaagtt cgggacggtt     7860

gtagcgcgtg acaggactca ggcgatagct gggctccgtg cattggcggc tggtcaacat     7920

gctcctgggg tcgtcaaccc agctgaaggt tccccaggac caggcaccgt gttcgttttt     7980

cccggtcaag gttcgcagag ggcagggatg ggggaggaac tcgcggcagc ctttcctgtc     8040

ttcgctcgaa tacatcagca agtttgggac ctcctagatg ttcccgacct cgacgttaat     8100

gaaaccgggt acgcccaacc agcgctgttc gcgcttcagg tcgcgctctt tggccttctg     8160

gagtcgtggg gtgttaggcc agatgcagtg gtagggcact cagttggtga gctggccgcg     8220

gggtacgtgt ccggtctttg gtcactagag gacgcctgca cactagtctc agcaagagcg     8280

cgcctaatgc aggcactgcc tgctggaggg gtgatggcgg cagtccccgt ctccgaggat     8340

gaggcgcggg ccgtcctggg cgagggagtt gaaattgcgg ctgtgaatgg accctcgtcc     8400

gttgtgctct caggggacga ggcggcagtc ttacaggccg ccgaaggtct aggtaagtgg     8460

acgcgactgc cgaccagcca tgcttttcac tcagcgagaa tggaacccat gctagaagag     8520

tttcgggccg tagcagaggg tctgacctat cgtacccctc aagtagctat ggctgctggg     8580

gatcaggtga tgacagcaga atattgggtg cggcaggttc gggacacagt tcgcttcggg     8640

gagcaagtag cgtcattcga ggatgcggtg tttgttgagt taggcgctga cagaagtcta     8700

gcgcgtttgg tggacggcat cgccatgctg cacggtgacc acgaagcgca ggccgcggac     8760

cataggcaaa tcaccgaagc ggttgcggat gcttacgtct taggccacct tccggatttt     8820

gcggcgctgc ggcggcctca cgcacgaaag ttggacttac caacttatcc cttcgagcgt     8880

agacagtact ggttcagaga tgcgcgtgag aggccggaac aacccagaga taccggcgga     8940

cctcgcacag aagcagtccg tctgttagag gatggtagga ttgaagaatt agctgcactt     9000

ttgggagggg ccagtgatga ccaacacaca ttacaggtgc tgactaagtt ggcggcgcaa     9060

cataaccaac aacgaacaac ccggtcaatc gctgacgaca ggtacgaaat aaggtgggac     9120

cgatcgactt ccccactatc cggagcagat gttgaccaag cggggagctg gatcgtggtg     9180

tcagatgacg cagatgccgt tcccccgcta gtggacttgc tggctgcacg taacgagccc     9240

catcaggttg ttggtctacc cgcttcggac gcagacgagg agaggctcgc agagactctg     9300

cgtgcggctg cgactgaaga tgctaccctt cggatagtcc acgttgcggc gctcgaagca     9360

ggcgctaccc ccagcatgcg ttcactgctc cgcatgcagc accgaatact aggtggcacg     9420

cggcgggtgt tcagggcagc ggtcgcagcg gagttaagag gtcccatttg gatagtgacg     9480

cggggagcac aaagagtggc tgacaccgat acagttgccc cgcatcagtc atgcctctgg     9540

ggatttggga gggcagcatc gctggagctg ccgcacgttt ggggtggcct agcagattta     9600

tcagagggcg gtgacaatgc ggccgatgag tggagtgcgc tagtggaccg cattgccgca     9660

ccccacggtt cagcagttag ggaggaccaa ctggcgctga gagacagggc cgtatatacg     9720

ccaagactgg ccagacgttc tgcgcccccg agcgggactc ccctacatct acgaggggat     9780

ggcacagtgt taataacagg tgggactggt acactaggta ggctattagc gcgtcaccta     9840

gtaacagagc atggggtgcg gcatctctta ctagtttcaa ggagaggcgc cgatgcccct     9900

ggctcggatg aactgcgcgc agaaatagag gacttaggtg ccagcgcgga gatcgcagcg     9960

tgtgatacag cggatcgcga tgccctatct gccctactag atggtctccc ccggcccctt    10020

acgggtgtcg ttcacgccgc tggcgtgtta gccgatggac ttgtcactag cattgacgag    10080

cctgcggtgg aacaggttct ccgagcaaag gtggacgcgg catggaacct acacgaactc    10140

acagctaata ccgggctatc ctttttcgtt cttttctcat cagcagcatc ggtcctggca    10200

ggtccagggc aaggagttta tgcggctgca aatgaatcgc tcaacgcact agctgcgtta    10260

aggcgaacta ggggtctgcc ggccaaggct ctgggatggg gcctgtgggc catcgggcgg    10320

gcaatcgctt ttgcggagca gaccggggac gccatcgctc cagaggaagg agcatacgct    10380

tttgaaactc tgttaaggca taaccgtgcc tactcgggat atgcgcccgt cattggatct    10440

ccctggttga ccgcgttcgc acagcattcc ccctttgcag aaaaattcca atcactcgga    10500

cagaatcggt cagggacatc gaaattctta gcggagctag ttgacctgcc tcgtgaggaa    10560

tggccggata ggctcaggag actactagag ttagttaggt cccatgccgc cgcggtctcc    10620

ggttacggta gtgcagatca actgccggaa agaaaagcgt tcaaggattt ggggtttgat    10680

tcgctggccg ccgttgaact gcgtaaccgg ctgggaacgg ctacaggggt acgactgccg    10740

tcaaccctag tatttgatca cccaactccg ctggccgtcg ctgagcactt aagagatagg    10800

ctaacatccg gggaagataa ccctatcccc ctatgtcaag gcgatgggga ggagatgagc    10860

acatggctac gtcgttttgg acccccagtc gaacatcggg ccaggctagt gtgtttcccc    10920

cacgcaggcg cagcggcgga ttcatactta gacctagcaa gagcgttagc accagagatc    10980

gatgttcatg ctgttcaata ccccggcagg caagacagaa gggacgagga gccattagga    11040

accgcaggtg aaattgcaga tgaagtggca gcggtgctac gtgcgtcggg aggggatggg    11100

ccttttgcac ttttcggcca cagtatgggc gccctcatcg cgtacgagac agcaaggcga    11160

ttagagaggg aaccgggagg gggaccctta cgtttattcg tgagcggaca aacagcgcca    11220

cgtgtccatg aacgaagaac tgatctgccc ggtgacgatg gactcgtgga cgagcttagg    11280

cgacttggca cctccgaggc agcgctcgca gacgaagccc tgctggctat gtctctcccg    11340

gtgctcaggg cggattatag ggtgttaaga tcctacgctt gggcggatgg tcccccacta    11400

cgcgccggta taactgccct ctgcggtgat gcagacccac taactgcaac aggggatgcg    11460

gaacgctggt tacaacattc cgtgattccg ggtcggacac ggacatttcc cggtgggcat    11520

ttttatttag gggaacaagt gaccgaggtg gcaggggctg tccgtagaga tttactgaga    11580

gcagggttag cgggttga                                                  11598


<210>  12
<211>  11937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IOS

<400>  12
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctact gccagtagaa cagccttttg tgcactcacc ggaagagcgg     6360

tatcgaccat tcgcgttaac ggatgttcag caagcctacc tggtcgggcg ccagccggga     6420

tttgccctgg gcggtgtagg ctcgcatttc ttcgtggaat tcgagatcgc agatctcgac     6480

atacaccgcc tggaaaaagt gtggaaccgt ttaattgcac gtcatgatat gttgcgcgct     6540

gtggttcgtg acggtcagca acgtgtactg gaacagaccc cgccatgggt cataccagca     6600

catattcttc acagtcctga agaggcatta caggttcgtg atcgtttagc tcaccaagtg     6660

ttgaaccccg aagtctggcc ggtatttgat ctgcaggtgg gcttcgttga cggtatgccg     6720

gcccgtttat ggttgtgcct tgataacctg ttattggacg ggctgagcat gcagattctt     6780

ctctctgaac tggagcatgg atatcgctac ccacagcaac tccctccccc gttgccgatc     6840

acttttcgcg attatcttca gcaaccggca ctccgtaccc caaatcctga ctcattggct     6900

tggtggcaga cgcaactgga tgacatccca cctgcgcccg ccctcccgct acgttgtctg     6960

cctcaagatg ttgaaacccc gcgtttcgcg cgtctgtacg gcgcaatgga ttctgctcgt     7020

tggcgtcgcc tgaaacagcg tgcggccgac gcacatctga ctccgtcagc tgtcctactg     7080

agcgtatggt ctacagtgct ggcagcttgg tcggcgcagc cggattttac tctcaacctg     7140

acattattcg accggcgacc actgcaccct cagattaatc aaatccttgg cgattttacc     7200

tcactgatgt tattgtcgtg gcatccgggt gagagttggc tgcagtccgc gcgtcttctc     7260

cagcaacgcc tttcagaatc gctcaaccac cgtgatgtta gcgccattcg cgtcatgcgg     7320

cagctggcga gaaggcaaaa tgtcccggcc gtacccatgc cggtcgtatt tacctctgcg     7380

ctggggtttg aacaggataa cttcctggcc cgtcgcaatc tactgaaacc ggtgtggggt     7440

atcagtcaga cgccgcaagt ttggctggac catcaggtct atgaatccga gggcgaactg     7500

cgttttaact gggatttcgt tgcggccctg tttccggacg gtcaagtgga acgtcagttc     7560

gcgcaatact gcgccttatt gaatcgcatg gcagaagatg acagctcttg gcagttgccg     7620

cttgctgatc tggtgccccc gttaaaagtg accgagcggc gagcgagaag gctgcgtcca     7680

gaacgcgccc agcctcgtat tgcagctgat aagagttccg ttagtctgat ctgtgacact     7740

tttcgtgagg tggttgggga acccgtggca ccggctgaga actttttcga agcgggagcc     7800

acatccctca atctggttca gctgcatgtc cttctccaac gtcacgaatt tgcgacctta     7860

acgctactgg atttgttcac ccatccaagc cctgttgcat tggctaacta tcttgcgggt     7920

gtggccctgg aagagaaaac gaagcgcgtg cggccggttc ggcgaagaca gcgtcgcatt     7980

cagcacttgc ccttagtagc tgcgcaacct ggaatatgga tggccgagaa gttatctgaa     8040

ctaccatcag cgtggagcgt agcgcattac gtggagctca ctggtgaggt tgactcgcct     8100

cttttggcca gggcggtagt ggctggcctt gcacaagctg acaccttaag aatgcgtttc     8160

acagaggata atggggaagt ttggcaatgg gtagacgatg cgttaacatt tgagttaccg     8220

gaaatcatag acctgcgcac taacatagac cctcacggga cagctcaggc cttgatgcaa     8280

gcggacctgc aacaggacct acgtgtggat tcggggaagc ctctggtctt ccatcagcta     8340

attcaagtag cggacaatcg ctggtactgg tatcaaaggt accaccactt gcttgtggac     8400

gggttcagtt ttccagcgat aaccaggcaa atagccaaca tttattgcac ttggttgcga     8460

ggagagccta cgcccgcatc ccccttcacg ccattcgcag acgttgttga ggaataccaa     8520

cagtatcgcg agagcgaagc gtggcaacgc gatgcggcat tctgggcgga gcaacgacgg     8580

caactaccgc ctcccgcatc cctatcacct gccccgctcc ccggccggtc cgcgtcagcc     8640

gacattctac ggctaaagct ggagttcaca gatggtgaat ttcgacagct tgctacacaa     8700

ctcagcgggg tacaaaggac agacctagcg ctcgctctgg ctgcattatg gctaggacga     8760

ctttgcaatc gaatggacta cgcggcgggt ttcatattta tgcgccggct cggcagcgca     8820

gcgttgaccg caacgggtcc agttttaaat gttcttcctt tgggaatcca cataggcaac     8880

ccaagcttct ctgagcttct caccagggtt cgcgaggtcg ccttaggcgc gtatgcacac     8940

caacatattc cttttgagat gttagtagag gcactgcaac cagagcgaaa ccttagccat     9000

actcctctct tccaagtgat gtttgtcctt cagaatgcgc ccgcgtccca attagagtta     9060

accgggatca ccgcaaaccc aattaaggtt aaatcaacta ccacgaagtt cgacctaact     9120

ttaatcatgc aaaacacagc tagcggatta gtaggtgttt gggagtacaa cacggattta     9180

ttcgacgcgt caacgattga gcgaatgaca gggcactttg taaccctcct cgagggcgtt     9240

atcgccaatc cacaacagcc gatctctcaa cttcctattt taactacagt ggagcaacag     9300

caacttttag tcgagtggaa taacacgcaa accgactacc ccgctgataa gtgtatacat     9360

caattattcg aggaacaggt cgagcgcaca ccagacgccg ttgctgtcgt ctttgggaat     9420

cagcaactca gctatcgaga gatgcgcgaa caagtggttg cactcgccaa tttattacgt     9480

gagcggggag tcaagccagg agactccgtt gccgtggcct taccacgctc tgttttctta     9540

acccttgcac tacacgcgat tgtcgaggca ggtgccgcct ggctacctct tgacacagga     9600

tatcctgacg atagattaaa aatgatgctc gaggatgcac ggccttccct tctgatcaca     9660

acagacgatc aattaccccg cttcagtgac gtacctaatc tgacctcact ctgttacaac     9720

gctcccttga cgcctcaagg gagcgcccct ttacagctgt ctcaacctca ccatactgca     9780

tatatcatct ttacaagtgg ttctacggga cgccccaagg gagtaatggt tggtcagact     9840

gcgattgtaa atcgtctgtt gtggatgcaa aaccactacc ctttgacggg ggaggacgtt     9900

gtagcccaaa agactccttg ctcgttcgat gtctcagtct gggagttctt ttggccattt     9960

atagcagggg ccaaattagt tatggcggag ccggaagccc accgagaccc acttgcgatg    10020

cagcaattct ttgctgagta tggtgtcacc actacacatt tcgtcccatc gatgttagcg    10080

gccttcgtgg cttctcttac tccacaaacg gctaggcaat cttgtgccac actaaagcaa    10140

gtcttctgct ccggcgaggc attacctgca gacttgtgcc gggaatggca gcaactcaca    10200

ggagctccat tgcacaatct atacggaccg accgaggccg cagtagacgt atcttggtat    10260

cctgcgtttg gcgaggagtt agcgcaagta agaggttcgt cagtaccaat aggatacccc    10320

gtatggaaca cggggcttcg gatactggac gcgatgatgc atccggtccc accaggagtc    10380

gcgggcgatt tatacctgac tgggatacag ctggcccaag gttacctagg gagacctgac    10440

cttacggcgt cgaggttcat agcggatccg tttgctccgg gtgagcgcat gtaccgtacg    10500

ggcgacgtcg cgcgatggct agataatggc gccgtagagt atcttggtag atcagacgat    10560

cagttaaaga tacggggaca acgaatagag cttggggaaa tagaccgggt aatgcaggct    10620

ttgccagatg tcgagcaagc ggtggcttcg tgtgctattg cgcgggagga catacctggg    10680

aacaaacacc ttgtagcgta catagttcct caagaggagc aaacatgcac tgagcgatcg    10740

aggtccacac ttacagtttc gttcgtccgg agtttcctta aggagaaact ccccgaatat    10800

atggtaccga gcgcaatagt gattctagac gctctccccc tgactcctaa tggaaagcta    10860

gaccggcggg cgttacccgc ccctgacctg cactcacaac ttgagacaat tattgctgcg    10920

gctttctcga gcctgctcgg gtgcgacgta caagacgcgg atgctgactt tttcgcgcta    10980

ggtggccatt cgctgcttgc catgaagcta gccgctcagc tttcccgaca agtagcgcgg    11040

caggtgacac caggccaagt tatggtagct tcgactgtcg caaagctcgc aacgatcata    11100

gacgcggagt tagataaata cgtcgctcca aggaacccga taacatccgg ggaagataac    11160

cctatccccc tatgtcaagg cgatggggag gagatgagca catggctacg tcgttttgga    11220

cccccagtcg aacatcgggc caggctagtg tgtttccccc acgcaggcgc agcggcggat    11280

tcatacttag acctagcaag agcgttagca ccagagatcg atgttcatgc tgttcaatac    11340

cccggcaggc aagacagaag ggacgaggag ccattaggaa ccgcaggtga aattgcagat    11400

gaagtggcag cggtgctacg tgcgtcggga ggggatgggc cttttgcact tttcggccac    11460

agtatgggcg ccctcatcgc gtacgagaca gcaaggcgat tagagaggga accgggaggg    11520

ggacccttac gtttattcgt gagcggacaa acagcgccac gtgtccatga acgaagaact    11580

gatctgcccg gtgacgatgg actcgtggac gagcttaggc gacttggcac ctccgaggca    11640

gcgctcgcag acgaagccct gctggctatg tctctcccgg tgctcagggc ggattatagg    11700

gtgttaagat cctacgcttg ggcggatggt cccccactac gcgccggtat aactgccctc    11760

tgcggtgatg cagacccact aactgcaaca ggggatgcgg aacgctggtt acaacattcc    11820

gtgattccgg gtcggacacg gacatttccc ggtgggcatt tttatttagg ggaacaagtg    11880

accgaggtgg caggggctgt ccgtagagat ttactgagag cagggttagc gggttga       11937


<210>  13
<211>  12282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ISC

<400>  13
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc cagcacttgc ccttagtagc tgcgcaacct     3540

ggaatatgga tggccgagaa gttatctgaa ctaccatcag cgtggagcgt agcgcattac     3600

gtggagctca ctggtgaggt tgactcgcct cttttggcca gggcggtagt ggctggcctt     3660

gcacaagctg acaccttaag aatgcgtttc acagaggata atggggaagt ttggcaatgg     3720

gtagacgatg cgttaacatt tgagttaccg gaaatcatag acctgcgcac taacatagac     3780

cctcacggga cagctcaggc cttgatgcaa gcggacctgc aacaggacct acgtgtggat     3840

tcggggaagc ctctggtctt ccatcagcta attcaagtag cggacaatcg ctggtactgg     3900

tatcaaaggt accaccactt gcttgtggac gggttcagtt ttccagcgat aaccaggcaa     3960

atagccaaca tttattgcac ttggttgcga ggagagccta cgcccgcatc ccccttcacg     4020

ccattcgcag acgttgttga ggaataccaa cagtatcgcg agagcgaagc gtggcaacgc     4080

gatgcggcat tctgggcgga gcaacgacgg caactaccgc ctcccgcatc cctatcacct     4140

gccccgctcc ccggccggtc cgcgtcagcc gacattctac ggctaaagct ggagttcaca     4200

gatggtgaat ttcgacagct tgctacacaa ctcagcgggg tacaaaggac agacctagcg     4260

ctcgctctgg ctgcattatg gctaggacga ctttgcaatc gaatggacta cgcggcgggt     4320

ttcatattta tgcgccggct cggcagcgca gcgttgaccg caacgggtcc agttttaaat     4380

gttcttcctt tgggaatcca cataggcaac ccaagcttct ctgagcttct caccagggtt     4440

cgcgaggtcg ccttaggcgc gtatgcacac caacatattc cttttgagat gttagtagag     4500

gcactgcaac cagagcgaaa ccttagccat actcctctct tccaagtgat gtttgtcctt     4560

cagaatgcgc ccgcgtccca attagagtta accgggatca ccgcaaaccc aattaaggtt     4620

aaatcaacta ccacgaagtt cgacctaact ttaatcatgc aaaacacagc tagcggatta     4680

gtaggtgttt gggagtacaa cacggattta ttcgacgcgt caacgattga gcgaatgaca     4740

gggcactttg taaccctcct cgagggcgtt atcgccaatc cacaacagcc gatctctcaa     4800

cttcctattt taactacagt ggagcaacag caacttttag tcgagtggaa taacacgcaa     4860

accgactacc ccgctgataa gtgtatacat caattattcg aggaacaggt cgagcgcaca     4920

ccagacgccg ttgctgtcgt ctttgggaat cagcaactca gctatcgaga gatgcgcgaa     4980

caagtggttg cactcgccaa tttattacgt gagcggggag tcaagccagg agactccgtt     5040

gccgtggcct taccacgctc tgttttctta acccttgcac tacacgcgat tgtcgaggca     5100

ggtgccgcct ggctacctct tgacacagga tatcctgacg atagattaaa aatgatgctc     5160

gaggatgcac ggccttccct tctgatcaca acagacgatc aattaccccg cttcagtgac     5220

gtacctaatc tgacctcact ctgttacaac gctcccttga cgcctcaagg gagcgcccct     5280

ttacagctgt ctcaacctca ccatactgca tatatcatct ttacaagtgg ttctacggga     5340

cgccccaagg gagtaatggt tggtcagact gcgattgtaa atcgtctgtt gtggatgcaa     5400

aaccactacc ctttgacggg ggaggacgtt gtagcccaaa agactccttg ctcgttcgat     5460

gtctcagtct gggagttctt ttggccattt atagcagggg ccaaattagt tatggcggag     5520

ccggaagccc accgagaccc acttgcgatg cagcaattct ttgctgagta tggtgtcacc     5580

actacacatt tcgtcccatc gatgttagcg gccttcgtgg cttctcttac tccacaaacg     5640

gctaggcaat cttgtgccac actaaagcaa gtcttctgct ccggcgaggc attacctgca     5700

gacttgtgcc gggaatggca gcaactcaca ggagctccat tgcacaatct atacggaccg     5760

accgaggccg cagtagacgt atcttggtat cctgcgtttg gcgaggagtt agcgcaagta     5820

agaggttcgt cagtaccaat aggatacccc gtatggaaca cggggcttcg gatactggac     5880

gcgatgatgc atccggtccc accaggagtc gcgggcgatt tatacctgac tgggatacag     5940

ctggcccaag gttacctagg gagacctgac cttacggcgt cgaggttcat agcggatccg     6000

tttgctccgg gtgagcgcat gtaccgtacg ggcgacgtcg cgcgatggct agataatggc     6060

gccgtagagt atcttggtag atcagacgat cagttaaaga tacggggaca acgaatagag     6120

cttggggaaa tagaccgggt aatgcaggct ttgccagatg tcgagcaagc ggtggcttcg     6180

tgtgctattg cgcgggagga catacctggg aacaaacacc ttgtagcgta catagttcct     6240

caagaggagc aaacatgcac tgagcgatcg aggtccacac ttacagtttc gttcgtccgg     6300

agtttcctta aggagaaact ccccgaatat atggtaccga gcgcaatagt gattctagac     6360

gctctccccc tgactcctaa tggaaagcta gaccggcggg cgttacccgc ccctgacctg     6420

cactcacaac ttgagacaat tattgctgcg gctttctcga gcctgctcgg gtgcgacgta     6480

caagacgcgg atgctgactt tttcgcgcta ggtggccatt cgctgcttgc catgaagcta     6540

gccgctcagc tttcccgaca agtagcgcgg caggtgacac caggccaagt tatggtagct     6600

tcgactgtcg caaagctcgc aacgatcata gacgcggagt tagataaata cgtcgctcca     6660

aggaacccga tactgccagt agaacagcct tttgtgcact caccggaaga gcggtatcga     6720

ccattcgcgt taacggatgt tcagcaagcc tacctggtcg ggcgccagcc gggatttgcc     6780

ctgggcggtg taggctcgca tttcttcgtg gaattcgaga tcgcagatct cgacatacac     6840

cgcctggaaa aagtgtggaa ccgtttaatt gcacgtcatg atatgttgcg cgctgtggtt     6900

cgtgacggtc agcaacgtgt actggaacag accccgccat gggtcatacc agcacatatt     6960

cttcacagtc ctgaagaggc attacaggtt cgtgatcgtt tagctcacca agtgttgaac     7020

cccgaagtct ggccggtatt tgatctgcag gtgggcttcg ttgacggtat gccggcccgt     7080

ttatggttgt gccttgataa cctgttattg gacgggctga gcatgcagat tcttctctct     7140

gaactggagc atggatatcg ctacccacag caactccctc ccccgttgcc gatcactttt     7200

cgcgattatc ttcagcaacc ggcactccgt accccaaatc ctgactcatt ggcttggtgg     7260

cagacgcaac tggatgacat cccacctgcg cccgccctcc cgctacgttg tctgcctcaa     7320

gatgttgaaa ccccgcgttt cgcgcgtctg tacggcgcaa tggattctgc tcgttggcgt     7380

cgcctgaaac agcgtgcggc cgacgcacat ctgactccgt cagctgtcct actgagcgta     7440

tggtctacag tgctggcagc ttggtcggcg cagccggatt ttactctcaa cctgacatta     7500

ttcgaccggc gaccactgca ccctcagatt aatcaaatcc ttggcgattt tacctcactg     7560

atgttattgt cgtggcatcc gggtgagagt tggctgcagt ccgcgcgtct tctccagcaa     7620

cgcctttcag aatcgctcaa ccaccgtgat gttagcgcca ttcgcgtcat gcggcagctg     7680

gcgagaaggc aaaatgtccc ggccgtaccc atgccggtcg tatttacctc tgcgctgggg     7740

tttgaacagg ataacttcct ggcccgtcgc aatctactga aaccggtgtg gggtatcagt     7800

cagacgccgc aagtttggct ggaccatcag gtctatgaat ccgagggcga actgcgtttt     7860

aactgggatt tcgttgcggc cctgtttccg gacggtcaag tggaacgtca gttcgcgcaa     7920

tactgcgcct tattgaatcg catggcagaa gatgacagct cttggcagtt gccgcttgct     7980

gatctggtgc ccccgttaaa agtgaccgag cggcgagcga gaaggctgcg tccagaacgc     8040

gcccagcctc gtattgcagc tgataagagt tccgttagtc tgatctgtga cacttttcgt     8100

gaggtggttg gggaacccgt ggcaccggct gagaactttt tcgaagcggg agccacatcc     8160

ctcaatctgg ttcagctgca tgtccttctc caacgtcacg aatttgcgac cttaacgcta     8220

ctggatttgt tcacccatcc aagccctgtt gcattggcta actatcttgc gggtgtggcc     8280

ctggaagaga aaacgaagcg cgtgcggccg gttcggcgaa gacagcgtcg cattggagag     8340

ccgttcccac tcgctcctat gcaacacgcc atgtgggtag ggcggcacga ccaccaacag     8400

ctcgggggag tagcaggcca tctttacgtc gagtttgacg gcgcgagagt cgaccccgat     8460

cggttgcgcg ctgccgccac ccgactcgcc ctacgtcacc ctatgttgag ggtacagttc     8520

ctgcctgacg gtacacaaag gatccctcca gccgcaggct cgcgggactt tcccatcagc     8580

gttgcggatc ttcgtcacgt agctcctgac gttgtcgatc aacggctcgc gggtattaga     8640

gacgcaaagt ctcatcaaca gcttgatgga gctgtcttcg agttggctct cactctcctg     8700

ccaggtgaaa ggacgaggct gcacgtcgac ctggatatgc aagctgctga cgccatgagc     8760

tacaggatcc tgctggcgga cttggccgca ctatacgacg ggagagagcc cccagcactc     8820

ggttacacgt atagagagta ccgccaggct attgaggccg aggaaacatt accgcaacct     8880

gttcgcgacg ccgataggga ctggtgggca caaagaatac cacagcttcc agacccgccc     8940

gcactaccga cgcgtgccgg tggtgagaga gatcgccggc gctcgaccag aagatggcac     9000

tggttagacc cacaaacaag ggacgccctc ttcgcacgag cacgagctcg tggcatcaca     9060

cctgcaatga cacttgcggc cgcgtttgca aatgtcctcg cgagatggtc cgcctcttcc     9120

cggttcttac tcaatttgcc ccttttctcg cgccaagcgt tgcatccgga cgtagacctc     9180

ttggtaggtg acttcacatc gtcgctgctg ttagatgttg acctaggaga tacagtgtct     9240

aatcttgctc ggaagaacca actgactttt acggaggact gggaacaccg gcattggagc     9300

ggagtagagt tgctgcgaga actcaaaagg caacagcgtt acccacacgg agcgcccgtg     9360

gtgttcactt ctaatcttgg gcgcagttta tattcttctc gggcggagtc ccccttggga     9420

gagcctgaat ggggaatttc gcaaacacca caggtttgga tcgaccattt agcatttgag     9480

caccatgggg aagtatggct ccaatgggac tcgaacgacg ccctcttccc acctgcttta     9540

gtcgagactc tgtttgacgc gtactgtcaa ttgataaacc agctgtgcga cgatgaatcc     9600

gcatggcaaa agcccttcgc ggacatgatg ccggcgagtc agcgtgctat tcgtgagcgg     9660

gtgaacgcta ccggcgcacc gatcccggag ggcctcttac acgaagggat ttttcggatc     9720

gctcttcaac agcctcaggc gctcgcggta acggacatgc ggtaccaatg gaatagttat     9780

cgagagatgc gggaacaggt cgtcgctttg gcaaatctac tccgagagcg cggggtcaag     9840

ccaggggact cagtcgctgt agcgcttcct cggtcagtct tcctaacctt ggctctccac     9900

gcgatcgtag aggcgggtgc ggcgtggctt cccctcgaca cgggctatcc ggacgatcgg     9960

ttgaagatga tgctagagga tgcacgaccc tctctgttaa tcacaaccga cgatcaactc    10020

cccaggttct cagacgtccc taatcttacc agtctatgtt acaacgcgcc cctcactcca    10080

caaggcagcg ctcctttaca acttagtcag ccgcaccata ccgcttatat catttttacg    10140

tccggttcca cgggcaggcc gaagggtgta atggtgggcc aaactgcaat agtgaataga    10200

ctattgtgga tgcaaaacca ctacccgctt accggggagg acgtagtggc tcaaaagact    10260

ccctgctctt tcgatgtcag cgtgtgggag ttcttttggc cttttatagc cggcgctaaa    10320

ttggttatgg cggagccgga agctcaccga gaccctttgg ccatgcaaca gttctttgca    10380

gagtatggag tcacaacgac gcatttcgtc ccatcgatgt tagccgcgtt cgtagcatca    10440

ttgacgccac aaactgcgag acagtcatgt gccacactta agcaagtctt ctgctctggt    10500

gaggcccttc ctgcggacct atgtcgggaa tggcaacagc ttactggagc ccccttgcac    10560

aatctttacg ggccgactga ggccgcagtt gacgtatcgt ggtatccagc gttcggggag    10620

gagctagccc aagtgcgagg gtctagtgtt ccaattggat acccggtgtg gaacacaggg    10680

ttaaggatcc tcgacgccat gatgcatccg gtaccaccag gtgtcgctgg ggatttgtac    10740

ctgactggca ttcaactggc acagggttat ctagggcggc ctgacttaac agctagccga    10800

ttcatagcag atccattcgc tcccggagag cggatgtacc gaacaggcga cgtggcacgc    10860

tggttagata atggcgctgt cgagtatctt gggcggtcag acgatcagtt aaagatacgt    10920

ggacaacgga ttgagcttgg tgaaatagac cgagttatgc aggcactacc agatgtcgag    10980

caagccgtag cctcttgtgc cattgcgcga gaagacattc ccgggaacaa gcacttggtt    11040

gcgtacatag tgccgcaaga ggagcagacc tgcacagagc ggtcacgttc aactctcaca    11100

gtttccttcg tccgttcttt cttaaaggag aaactaccag aatatatggt accgtccgcg    11160

atcgtgatat tagacgctct gccactcacg ccaaatggaa agttggatag aagagctctg    11220

cctgctcctg acttgcactc gcaactcctg gataaatacg ttgctcccag aaacccaata    11280

gagactatta tcgcggcagc attctcttca ttgcttggat gcgacgtcca agatgcggac    11340

gcagatttct ttgcgctcgg gggccatagt ctattggcca tgaagctcgc agcgcaattg    11400

tcgagacagg tagcacggca agtaacgccc gggcaagtca tggtcgcctc gacagtcgcg    11460

aaactcgcga ccattatcga cgctgagaca tccggggaag ataaccctat ccccctatgt    11520

caaggcgatg gggaggagat gagcacatgg ctacgtcgtt ttggaccccc agtcgaacat    11580

cgggccaggc tagtgtgttt cccccacgca ggcgcagcgg cggattcata cttagaccta    11640

gcaagagcgt tagcaccaga gatcgatgtt catgctgttc aataccccgg caggcaagac    11700

agaagggacg aggagccatt aggaaccgca ggtgaaattg cagatgaagt ggcagcggtg    11760

ctacgtgcgt cgggagggga tgggcctttt gcacttttcg gccacagtat gggcgccctc    11820

atcgcgtacg agacagcaag gcgattagag agggaaccgg gagggggacc cttacgttta    11880

ttcgtgagcg gacaaacagc gccacgtgtc catgaacgaa gaactgatct gcccggtgac    11940

gatggactcg tggacgagct taggcgactt ggcacctccg aggcagcgct cgcagacgaa    12000

gccctgctgg ctatgtctct cccggtgctc agggcggatt atagggtgtt aagatcctac    12060

gcttgggcgg atggtccccc actacgcgcc ggtataactg ccctctgcgg tgatgcagac    12120

ccactaactg caacagggga tgcggaacgc tggttacaac attccgtgat tccgggtcgg    12180

acacggacat ttcccggtgg gcatttttat ttaggggaac aagtgaccga ggtggcaggg    12240

gctgtccgta gagatttact gagagcaggg ttagcgggtt ga                       12282


<210>  14
<211>  13605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ISH

<400>  14
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc cagcacttgc ccttagtagc tgcgcaacct     3540

ggaatatgga tggccgagaa gttatctgaa ctaccatcag cgtggagcgt agcgcattac     3600

gtggagctca ctggtgaggt tgactcgcct cttttggcca gggcggtagt ggctggcctt     3660

gcacaagctg acaccttaag aatgcgtttc acagaggata atggggaagt ttggcaatgg     3720

gtagacgatg cgttaacatt tgagttaccg gaaatcatag acctgcgcac taacatagac     3780

cctcacggga cagctcaggc cttgatgcaa gcggacctgc aacaggacct acgtgtggat     3840

tcggggaagc ctctggtctt ccatcagcta attcaagtag cggacaatcg ctggtactgg     3900

tatcaaaggt accaccactt gcttgtggac gggttcagtt ttccagcgat aaccaggcaa     3960

atagccaaca tttattgcac ttggttgcga ggagagccta cgcccgcatc ccccttcacg     4020

ccattcgcag acgttgttga ggaataccaa cagtatcgcg agagcgaagc gtggcaacgc     4080

gatgcggcat tctgggcgga gcaacgacgg caactaccgc ctcccgcatc cctatcacct     4140

gccccgctcc ccggccggtc cgcgtcagcc gacattctac ggctaaagct ggagttcaca     4200

gatggtgaat ttcgacagct tgctacacaa ctcagcgggg tacaaaggac agacctagcg     4260

ctcgctctgg ctgcattatg gctaggacga ctttgcaatc gaatggacta cgcggcgggt     4320

ttcatattta tgcgccggct cggcagcgca gcgttgaccg caacgggtcc agttttaaat     4380

gttcttcctt tgggaatcca cataggcaac ccaagcttct ctgagcttct caccagggtt     4440

cgcgaggtcg ccttaggcgc gtatgcacac caacatattc cttttgagat gttagtagag     4500

gcactgcaac cagagcgaaa ccttagccat actcctctct tccaagtgat gtttgtcctt     4560

cagaatgcgc ccgcgtccca attagagtta accgggatca ccgcaaaccc aattaaggtt     4620

aaatcaacta ccacgaagtt cgacctaact ttaatcatgc aaaacacagc tagcggatta     4680

gtaggtgttt gggagtacaa cacggattta ttcgacgcgt caacgattga gcgaatgaca     4740

gggcactttg taaccctcct cgagggcgtt atcgccaatc cacaacagcc gatctctcaa     4800

cttcctattt taactacagt ggagcaacag caacttttag tcgagtggaa taacacgcaa     4860

accgactacc ccgctgataa gtgtatacat caattattcg aggaacaggt cgagcgcaca     4920

ccagacgccg ttgctgtcgt ctttgggaat cagcaactca gctatcgaga gatgcgcgaa     4980

caagtggttg cactcgccaa tttattacgt gagcggggag tcaagccagg agactccgtt     5040

gccgtggcct taccacgctc tgttttctta acccttgcac tacacgcgat tgtcgaggca     5100

ggtgccgcct ggctacctct tgacacagga tatcctgacg atagattaaa aatgatgctc     5160

gaggatgcac ggccttccct tctgatcaca acagacgatc aattaccccg cttcagtgac     5220

gtacctaatc tgacctcact ctgttacaac gctcccttga cgcctcaagg gagcgcccct     5280

ttacagctgt ctcaacctca ccatactgca tatatcatct ttacaagtgg ttctacggga     5340

cgccccaagg gagtaatggt tggtcagact gcgattgtaa atcgtctgtt gtggatgcaa     5400

aaccactacc ctttgacggg ggaggacgtt gtagcccaaa agactccttg ctcgttcgat     5460

gtctcagtct gggagttctt ttggccattt atagcagggg ccaaattagt tatggcggag     5520

ccggaagccc accgagaccc acttgcgatg cagcaattct ttgctgagta tggtgtcacc     5580

actacacatt tcgtcccatc gatgttagcg gccttcgtgg cttctcttac tccacaaacg     5640

gctaggcaat cttgtgccac actaaagcaa gtcttctgct ccggcgaggc attacctgca     5700

gacttgtgcc gggaatggca gcaactcaca ggagctccat tgcacaatct atacggaccg     5760

accgaggccg cagtagacgt atcttggtat cctgcgtttg gcgaggagtt agcgcaagta     5820

agaggttcgt cagtaccaat aggatacccc gtatggaaca cggggcttcg gatactggac     5880

gcgatgatgc atccggtccc accaggagtc gcgggcgatt tatacctgac tgggatacag     5940

ctggcccaag gttacctagg gagacctgac cttacggcgt cgaggttcat agcggatccg     6000

tttgctccgg gtgagcgcat gtaccgtacg ggcgacgtcg cgcgatggct agataatggc     6060

gccgtagagt atcttggtag atcagacgat cagttaaaga tacggggaca acgaatagag     6120

cttggggaaa tagaccgggt aatgcaggct ttgccagatg tcgagcaagc ggtggcttcg     6180

tgtgctattg cgcgggagga catacctggg aacaaacacc ttgtagcgta catagttcct     6240

caagaggagc aaacatgcac tgagcgatcg aggtccacac ttacagtttc gttcgtccgg     6300

agtttcctta aggagaaact ccccgaatat atggtaccga gcgcaatagt gattctagac     6360

gctctccccc tgactcctaa tggaaagcta gaccggcggg cgttacccgc ccctgacctg     6420

cactcacaac ttgagacaat tattgctgcg gctttctcga gcctgctcgg gtgcgacgta     6480

caagacgcgg atgctgactt tttcgcgcta ggtggccatt cgctgcttgc catgaagcta     6540

gccgctcagc tttcccgaca agtagcgcgg caggtgacac caggccaagt tatggtagct     6600

tcgactgtcg caaagctcgc aacgatcata gacgcggagt tagataaata cgtcgctcca     6660

aggaacccga tacctggaat tggggcgcta gttcccgctc ccgtggtaat cgcagcaggc     6720

cgtacggagg aaccaattgc catagtatcc atggcttgcc ggttacccgg tggtgtgaat     6780

accccacaga gactatggga attattacgt gaagggggag aaaccctcag tggcttccct     6840

accgaccgag ggtgggacct cgcgaggttg catcacccag acccagacaa ccccggtacg     6900

tcatacgttg ataaaggggg attcctggac gatgcggcag ggtttgacgc agaatttttc     6960

ggtgtgagcc ccagagaagc agcggctatg gacccgcagc agagattact cctcgaaacc     7020

agctgggagt tagtcgagaa tgcagggatt gatccacata gcctaagggg gaccgccact     7080

ggtgtcttcc tcggcgttgc caagtttggg tatggcgagg atacggcagc tgccgaagac     7140

gtcgaggggt actctgtcac tggtgtagcc ccggcagtgg cgtcgggcag aattagttac     7200

acgatggggt tggaagggcc gtctatttcg gttgataccg cctgttcctc cagtctggtt     7260

gcactccacc ttgcagtcga gtcgctccgg aaaggagaaa gcagtatggc cgtggtcggg     7320

ggagcggcgg tgatggccac accgggtgtg tttgtggatt tttcccgaca gagagccttg     7380

gccgcggatg ggcgttcaaa ggcgttcgga gcaggtgcag acgggtttgg atttagcgaa     7440

ggtgtgacac tggttctcct agaaagatta agtgaagccc ggcgtaacgg ccatgaggtg     7500

ctggcagttg ttagaggttc cgcattaaac caggacgggg cttcgaacgg gctgagcgcc     7560

ccctcgggcc cggcacagag aagagtgata cgccaagcac tcgaatcgtg tggcctagaa     7620

ccaggtgacg ttgacgcggt ggaagcgcac gggacaggaa ctgcgttagg ggacccgata     7680

gaagcaaacg ccttgctgga cacttatggt agagatcgtg atgcggatcg acccctctgg     7740

ttaggaagtg ttaagtcaaa tataggacac actcaggcag cggcgggagt aactgggctg     7800

ctcaaagtag tcctagcctt acgcaatggg gaactacccg ccaccctaca tgtcgaggaa     7860

ccgacaccgc atgtggattg gtcgagcggg ggagttgctc tcttggcggg taatcagccg     7920

tggcgaagag gtgaacgaac ccgtagagcc gccgtgtccg cattcgggat cagtggtacg     7980

aacgcgcacg tgattgtgga agaagctcca caagaggtga gaccagcgcc cggtcaagga     8040

ctctcgcccg cggtgtcaac cttggtagtg gcgggtaaaa ctatgcagcg tgtttcggca     8100

accgccggta tgctcgcaga ttggatggaa ggcccaggtg cagatgtggc gctggcggac     8160

gtggcgcaca cgttaaatca tcaccgttca cggcaaccaa agttcggtac ggtggtggcc     8220

agggaccgga cacaggcaat cgccggacta agagcgctgg cggcgggtca gcacgcccca     8280

ggggttgtta accctgctga aggaagtcca ggtccaggga cggtgttcgt gtttcctggc     8340

caggggtccc agcgtgcagg catgggggag gagttggctg cggctttccc cgtgtttgcc     8400

agaatccacc agcaagtgtg ggatttactc gatgttcctg atctcgacgt taacgaaacg     8460

gggtacgcac aaccagcact cttcgcactc caagtggcgc tgtttgggct cctcgaatca     8520

tggggagtac ggccggatgc cgtggtcggg catagtgtag gggaattagc ggcagggtac     8580

gtttccgggc tttggagtct tgaggatgct tgcacgctcg tgtcggcgag agcccgtcta     8640

atgcaagcct taccggcagg tggtgttatg gcggcagttc cagtgtccga agacgaagca     8700

cgggctgtgt tgggggaagg agtcgaaata gctgcggtca acggtccgtc gagcgtggtt     8760

ctaagcggtg atgaagcagc agtgctccag gccgcggaag ggttaggcaa gtggacgcga     8820

ttaccgacct cgcatgcatt ccattctgct cgtatggaac caatgctgga agagtttaga     8880

gcagtggcgg aaggtctaac atacaggact ccccaggtgg caatggccgc cggagaccag     8940

gttatgaccg ctgaatactg ggtgcgtcag gttagggata cagttcgttt tggcgagcaa     9000

gttgcctcgt tcgaggatgc tgtattcgtg gaattgggag cagatcgctc tcttgcacgg     9060

ctagtcgatg gtatcgcgat gttgcacggg gatcatgagg cacaggctgg tatgcggaga     9120

gaacaaccct tgcccttagg tttacgaaga ttgctaaccg acctgcataa cgctggtgct     9180

gccgtcgatt ttagtgtttt gtgcccacaa ggtcgtctgg ttgacgcacc gttaccagcc     9240

tggtcacacc ggtttctctt ctatgaccgg gaaggagtgg acaatagatc accaggggga     9300

agcacagtgg cggtccaccc gcttttacta gccgcggtgg atgtgccggg ccacggtgga     9360

gcggttttca cgggtagact ctcgactgac gagcaaccgt ggttagcgga gcacgttgtc     9420

gggggaagaa ccctagttcc tggttctgtt ttagtcgatc tagccttagc ggcaggcgaa     9480

gacgtagggc taccggtgtt agaagaatta gtattgcaga ggccgctggt gcttgccggc     9540

gcgggagcac tcctacggat gtcggtcggg gcaccagacg agagcggtag aagaactatc     9600

gatgttcacg cagctgaaga cgtcgccgat ttagcagatg cccaatggtc ccagcacgcc     9660

accgggactt tagcccaagg ggtagcggcg gggcccaggg acacagagca atggccccca     9720

gaggatgccg tccggattcc attagacgac cattatgatg gtctcgcgga acagggttat     9780

gagtacggtc cgtcgtttca ggcgctagtg gcctacgtgg cggaggatgc gactgcgaca     9840

atgttagcgg aagtcgcgct tccgggcagc attagatcgc aacaaggtct atacgccatc     9900

catcccgcac tgctggacgc ttgttttcaa tctgtcggag cccacccaga cagtcaatcc     9960

gtcgggtcag gtctactcgt acccctcggt gttcggagag ttcgtgcgta cgcacccgta    10020

aggaccgccc gttattgtta cacccgcgtc acgaaagttg aactagctgg ggttgaggcc    10080

gacatcgacg ttctggatgc tcacggcaca gtgcttctag ccgtgtgcgg tcttcgtatc    10140

gggaccggag tgagcgagag ggacaaacac aacagagttc tcaatgagcg cctactcacc    10200

atcgaatggc atcagcgtga actaccagaa atggacccct cgggtgccgg gaagtggctc    10260

ctaatctcgg actgtgcagc atccgatgtc accgctacac gactggctga tgccttccgg    10320

gagcacagcg ctgcgtgcac taccatgcgg tggccacttc acgatgatca actagcagcc    10380

gccgaccaac tccgggacca ggtgggttca gatgagtttt ctggcgtggt agtactaaca    10440

gggccaaaca cagggacccc tcatcagggt tccgcagacc gtggcgccga gtacgttagg    10500

cggttagttg gaatcgctcg tgaacttagc gatcttcccg gagcggttcc ccgtatgtat    10560

gtcgtcacaa ggggagcgca gagagtcctt gccgatgatt gtgttaattt agaacaggga    10620

gggctcagag gtctgctgag gaccatcggt gctgagcacc cacatctccg cgccacccaa    10680

attgatgttg atgagcagac aggagtagag cagctggcgc gacaactcct agctacatcg    10740

gaggaagacg agacagcctg gagggacaac gaatggtacg ttgcgaggtt atgccccaca    10800

cccctgaggc cacaggaacg taggacaata gtggcggacc atcaacagtc tggtatgcgg    10860

ttacaaatac gtacgcccgg tgcaatcgat agtgtggcct ttgaacccgc acccgatgta    10920

gagcaaccct tacgggcggg tgaagttcgg gttgacgtta gagcaaccgg tgttaatttc    10980

cgtgacgttc tactcgctct cgggatgtat ccccagaaag ctgacatggg gacagaagca    11040

gctggtgttg taacagcagt gggacctgat gtcgatgcgt ttgcgcctgg tgatagagtt    11100

ctagggctat tccaaggggc atttgctcca attgcggtga ctgaccatcg tttactggca    11160

cgggtgccag acgggtggtc agatgccgat gcggcggcgg tgccaatagc ttacacgaca    11220

gcacattatg cgctgcacga cctggcgggg ttgcgggcgg ggcaatctgt cctgatacac    11280

gcggcagcgg gtggtgttgg tatggccgct gttgcactgg cacggagggc cggcgcagaa    11340

gttctggcta ccgcaggacc tgcaaaacac ggtacgctac gggcattagg gctagatgat    11400

gaacacatcg cttcgagtcg ggagaccggg ttcgcgcgta agttccgaga gcggactggg    11460

ggacgaggag tggacgtcgt tctaaacagc ttgaccggcg aactattaga cgagtccgcg    11520

gatctcctcg cggaggacgg agtcttcgtg gaaatgggaa agactgatct gcgcgatgca    11580

ggggactttc gtgggcgcta cgccccgttt gatctagggg aagcaggcga tgacaggctc    11640

ggggaaattc tacgtgaggt ggtgggactg ctcggtgcag gggaactcga ccgactccct    11700

gttagcgcgt gggaattggg gataccccag acggggaagt cgttagtgac gctgccaccc    11760

gaacaagcgc aagttttcag accagacggc actgtattga tcaccggggg aacgggaacg    11820

ttaggtcggc tgctggcccg tcatctggtt acagagcacg gggtgcgtca cctgctgcta    11880

gtgtcgagga gaggagcaga tgcccctgga tcggacgagc tgagggccga aatcgaggat    11940

ctcggagcat cagcggaaat tgcagcatgt gatacagccg atcgagacgc tctcagcgcg    12000

ttgctagatg gactgccgag gccactgacc ggagtagttc acgccgcggg agtcctcgct    12060

gacggtctgg ttacatccat cgacgagccc gcagtcgaac aagttctccg tgcaaaagtt    12120

gatgcggcct ggaacctgca cgagctaact gcgaacaccg gtctcagctt tttcgtgctg    12180

ttctcgtcag ccgcaagtgt gttagcgggg ccggggcagg gagtatatgc ggcagcgaac    12240

gaatctttaa acgctctggc cgctctgcgt aggactaggg gtttacccgc aaaagcattg    12300

ggatggggat tatgggcgat agggcgtgca atagcatttg ccgagcagac cggtgacgca    12360

atcgccccgg aggaaggcgc gtacgccttc gagacactac tcagacataa cagggcgtac    12420

tcgggttacg ctcccgtgat agggtcacca tggctgactg cgttcgccca acattcgccc    12480

tttgcggaga agttccagtc cctggggcaa aatagatccg ggacgtctaa gtttctggca    12540

gaattagtcg atctgccaag agaagaatgg ccagatcggt tacgtcgtct attagaactg    12600

gtgaggtctc atgctgccgc agtttcgggg tatggatcgg cagaccaatt accagaaaga    12660

aaagcattca aagacctcgg attcgattca ctggcagcag tcgaactaag aaatcgtcta    12720

gggaccgcga caggcgtccg gctgcccagt actctggtgt tcgaccaccc aaccccactt    12780

gcggttgcgg aacatctacg tgatcgtcta acatccgggg aagataaccc tatcccccta    12840

tgtcaaggcg atggggagga gatgagcaca tggctacgtc gttttggacc cccagtcgaa    12900

catcgggcca ggctagtgtg tttcccccac gcaggcgcag cggcggattc atacttagac    12960

ctagcaagag cgttagcacc agagatcgat gttcatgctg ttcaataccc cggcaggcaa    13020

gacagaaggg acgaggagcc attaggaacc gcaggtgaaa ttgcagatga agtggcagcg    13080

gtgctacgtg cgtcgggagg ggatgggcct tttgcacttt tcggccacag tatgggcgcc    13140

ctcatcgcgt acgagacagc aaggcgatta gagagggaac cgggaggggg acccttacgt    13200

ttattcgtga gcggacaaac agcgccacgt gtccatgaac gaagaactga tctgcccggt    13260

gacgatggac tcgtggacga gcttaggcga cttggcacct ccgaggcagc gctcgcagac    13320

gaagccctgc tggctatgtc tctcccggtg ctcagggcgg attatagggt gttaagatcc    13380

tacgcttggg cggatggtcc cccactacgc gccggtataa ctgccctctg cggtgatgca    13440

gacccactaa ctgcaacagg ggatgcggaa cgctggttac aacattccgt gattccgggt    13500

cggacacgga catttcccgg tgggcatttt tatttagggg aacaagtgac cgaggtggca    13560

ggggctgtcc gtagagattt actgagagca gggttagcgg gttga                    13605


<210>  15
<211>  11952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ISO

<400>  15
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc cagcacttgc ccttagtagc tgcgcaacct     3540

ggaatatgga tggccgagaa gttatctgaa ctaccatcag cgtggagcgt agcgcattac     3600

gtggagctca ctggtgaggt tgactcgcct cttttggcca gggcggtagt ggctggcctt     3660

gcacaagctg acaccttaag aatgcgtttc acagaggata atggggaagt ttggcaatgg     3720

gtagacgatg cgttaacatt tgagttaccg gaaatcatag acctgcgcac taacatagac     3780

cctcacggga cagctcaggc cttgatgcaa gcggacctgc aacaggacct acgtgtggat     3840

tcggggaagc ctctggtctt ccatcagcta attcaagtag cggacaatcg ctggtactgg     3900

tatcaaaggt accaccactt gcttgtggac gggttcagtt ttccagcgat aaccaggcaa     3960

atagccaaca tttattgcac ttggttgcga ggagagccta cgcccgcatc ccccttcacg     4020

ccattcgcag acgttgttga ggaataccaa cagtatcgcg agagcgaagc gtggcaacgc     4080

gatgcggcat tctgggcgga gcaacgacgg caactaccgc ctcccgcatc cctatcacct     4140

gccccgctcc ccggccggtc cgcgtcagcc gacattctac ggctaaagct ggagttcaca     4200

gatggtgaat ttcgacagct tgctacacaa ctcagcgggg tacaaaggac agacctagcg     4260

ctcgctctgg ctgcattatg gctaggacga ctttgcaatc gaatggacta cgcggcgggt     4320

ttcatattta tgcgccggct cggcagcgca gcgttgaccg caacgggtcc agttttaaat     4380

gttcttcctt tgggaatcca cataggcaac ccaagcttct ctgagcttct caccagggtt     4440

cgcgaggtcg ccttaggcgc gtatgcacac caacatattc cttttgagat gttagtagag     4500

gcactgcaac cagagcgaaa ccttagccat actcctctct tccaagtgat gtttgtcctt     4560

cagaatgcgc ccgcgtccca attagagtta accgggatca ccgcaaaccc aattaaggtt     4620

aaatcaacta ccacgaagtt cgacctaact ttaatcatgc aaaacacagc tagcggatta     4680

gtaggtgttt gggagtacaa cacggattta ttcgacgcgt caacgattga gcgaatgaca     4740

gggcactttg taaccctcct cgagggcgtt atcgccaatc cacaacagcc gatctctcaa     4800

cttcctattt taactacagt ggagcaacag caacttttag tcgagtggaa taacacgcaa     4860

accgactacc ccgctgataa gtgtatacat caattattcg aggaacaggt cgagcgcaca     4920

ccagacgccg ttgctgtcgt ctttgggaat cagcaactca gctatcgaga gatgcgcgaa     4980

caagtggttg cactcgccaa tttattacgt gagcggggag tcaagccagg agactccgtt     5040

gccgtggcct taccacgctc tgttttctta acccttgcac tacacgcgat tgtcgaggca     5100

ggtgccgcct ggctacctct tgacacagga tatcctgacg atagattaaa aatgatgctc     5160

gaggatgcac ggccttccct tctgatcaca acagacgatc aattaccccg cttcagtgac     5220

gtacctaatc tgacctcact ctgttacaac gctcccttga cgcctcaagg gagcgcccct     5280

ttacagctgt ctcaacctca ccatactgca tatatcatct ttacaagtgg ttctacggga     5340

cgccccaagg gagtaatggt tggtcagact gcgattgtaa atcgtctgtt gtggatgcaa     5400

aaccactacc ctttgacggg ggaggacgtt gtagcccaaa agactccttg ctcgttcgat     5460

gtctcagtct gggagttctt ttggccattt atagcagggg ccaaattagt tatggcggag     5520

ccggaagccc accgagaccc acttgcgatg cagcaattct ttgctgagta tggtgtcacc     5580

actacacatt tcgtcccatc gatgttagcg gccttcgtgg cttctcttac tccacaaacg     5640

gctaggcaat cttgtgccac actaaagcaa gtcttctgct ccggcgaggc attacctgca     5700

gacttgtgcc gggaatggca gcaactcaca ggagctccat tgcacaatct atacggaccg     5760

accgaggccg cagtagacgt atcttggtat cctgcgtttg gcgaggagtt agcgcaagta     5820

agaggttcgt cagtaccaat aggatacccc gtatggaaca cggggcttcg gatactggac     5880

gcgatgatgc atccggtccc accaggagtc gcgggcgatt tatacctgac tgggatacag     5940

ctggcccaag gttacctagg gagacctgac cttacggcgt cgaggttcat agcggatccg     6000

tttgctccgg gtgagcgcat gtaccgtacg ggcgacgtcg cgcgatggct agataatggc     6060

gccgtagagt atcttggtag atcagacgat cagttaaaga tacggggaca acgaatagag     6120

cttggggaaa tagaccgggt aatgcaggct ttgccagatg tcgagcaagc ggtggcttcg     6180

tgtgctattg cgcgggagga catacctggg aacaaacacc ttgtagcgta catagttcct     6240

caagaggagc aaacatgcac tgagcgatcg aggtccacac ttacagtttc gttcgtccgg     6300

agtttcctta aggagaaact ccccgaatat atggtaccga gcgcaatagt gattctagac     6360

gctctccccc tgactcctaa tggaaagcta gaccggcggg cgttacccgc ccctgacctg     6420

cactcacaac ttgagacaat tattgctgcg gctttctcga gcctgctcgg gtgcgacgta     6480

caagacgcgg atgctgactt tttcgcgcta ggtggccatt cgctgcttgc catgaagcta     6540

gccgctcagc tttcccgaca agtagcgcgg caggtgacac caggccaagt tatggtagct     6600

tcgactgtcg caaagctcgc aacgatcata gacgcggagt tagataaata cgtcgctcca     6660

aggaacccga tacctggaat tggggcgcta gttcccgctc ccgtggtaat cgcagcaggc     6720

cgtacggagg aaccaattgc catcgtttcg atggcatgtc gtttaccggg aggagtcaat     6780

acgccccaac ggctctggga attactacgg gagggtggtg aaaccttgtc cgggttccca     6840

acggaccgtg gctgggacct agcacggctt caccaccctg atccggacaa ccccggaacg     6900

agctacgttg ataagggtgg atttctcgac gacgcggcgg gtttcgacgc agagtttttc     6960

ggggtttcac caagggaagc tgccgctatg gaccctcagc aacgattact tttagagacc     7020

tcgtgggagc tagttgaaaa tgcgggcata gatccacata gcctgcgagg gacagcgaca     7080

ggggtgttcc taggagttgc gaagtttggt tatggtgagg acacagcagc agcggaagat     7140

gttgaaggtt attcagttac cggtgttgct cccgctgtgg catctggccg catatcctac     7200

actatgggtt tagaaggtcc ttccatctcg gtcgataccg catgctcaag ctcgctagtc     7260

gcgcttcatc tagccgtaga gtccctccga aagggtgagt catctatggc ggtggtgggt     7320

ggtgcagccg ttatggcgac tcctggggta tttgttgatt tttcacgcca acgggcgctt     7380

gccgcagacg gccgttccaa agcgttcggg gcaggtgcag atggttttgg tttcagcgag     7440

ggagtcacgc tggttctact agagcgttta agtgaggcgc gtcgtaacgg tcatgaagtt     7500

ctagctgtag tgcgcgggtc cgcgttaaac caggacggag cgagcaacgg actttcagca     7560

ccctccggcc ctgcgcaacg tagagtaata aggcaagcgc tcgaatcgtg tgggcttgaa     7620

ccgggggatg ttgacgcggt tgaggcgcat ggtactggta cagcactagg tgacccaata     7680

gaggccaatg cgctgttgga cacttacggg cgagaccgtg atgcggatcg tccactttgg     7740

ttggggtccg ttaagagcaa tattgggcac actcaagctg cggccggggt tacaggactg     7800

ctgaaggttg tgttagcact gcgcaatggt gagctacctg caacgttaca tgtcgaggaa     7860

ccaactccac acgtcgattg gtcctcaggt ggtgtcgcat tactggcggg taatcaacca     7920

tggcgaaggg gagaaaggac cagaagggcg gcagtgagcg cctttggtat ctccggtaca     7980

aatgctcacg tgatagtgga agaggcgcct caggaagttc gacccgcccc tggccaaggg     8040

ctgtcgccag ccgtgtccac gttagttgtt gcaggtaaaa ccatgcagcg tgtaagtgcg     8100

acagctggaa tgcttgcaga ctggatggag ggtcctgggg ccgatgttgc attggcggat     8160

gtggcccata ccctgaacca tcaccgatca agacagccca agttcgggac ggttgtagcg     8220

cgtgacagga ctcaggcgat agctgggctc cgtgcattgg cggctggtca acatgctcct     8280

ggggtcgtca acccagctga aggttcccca ggaccaggca ccgtgttcgt ttttcccggt     8340

caaggttcgc agagggcagg gatgggggag gaactcgcgg cagcctttcc tgtcttcgct     8400

cgaatacatc agcaagtttg ggacctccta gatgttcccg acctcgacgt taatgaaacc     8460

gggtacgccc aaccagcgct gttcgcgctt caggtcgcgc tctttggcct tctggagtcg     8520

tggggtgtta ggccagatgc agtggtaggg cactcagttg gtgagctggc cgcggggtac     8580

gtgtccggtc tttggtcact agaggacgcc tgcacactag tctcagcaag agcgcgccta     8640

atgcaggcac tgcctgctgg aggggtgatg gcggcagtcc ccgtctccga ggatgaggcg     8700

cgggccgtcc tgggcgaggg agttgaaatt gcggctgtga atggaccctc gtccgttgtg     8760

ctctcagggg acgaggcggc agtcttacag gccgccgaag gtctaggtaa gtggacgcga     8820

ctgccgacca gccatgcttt tcactcagcg agaatggaac ccatgctaga agagtttcgg     8880

gccgtagcag agggtctgac ctatcgtacc cctcaagtag ctatggctgc tggggatcag     8940

gtgatgacag cagaatattg ggtgcggcag gttcgggaca cagttcgctt cggggagcaa     9000

gtagcgtcat tcgaggatgc ggtgtttgtt gagttaggcg ctgacagaag tctagcgcgt     9060

ttggtggacg gcatcgccat gctgcacggt gaccacgaag cgcaggccgc ggaccatagg     9120

caaatcaccg aagcggttgc ggatgcttac gtcttaggcc accttccgga ttttgcggcg     9180

ctgcggcggc ctcacgcacg aaagttggac ttaccaactt atcccttcga gcgtagacag     9240

tactggttca gagatgcgcg tgagaggccg gaacaaccca gagataccgg cggacctcgc     9300

acagaagcag tccgtctgtt agaggatggt aggattgaag aattagctgc acttttggga     9360

ggggccagtg atgaccaaca cacattacag gtgctgacta agttggcggc gcaacataac     9420

caacaacgaa caacccggtc aatcgctgac gacaggtacg aaataaggtg ggaccgatcg     9480

acttccccac tatccggagc agatgttgac caagcgggga gctggatcgt ggtgtcagat     9540

gacgcagatg ccgttccccc gctagtggac ttgctggctg cacgtaacga gccccatcag     9600

gttgttggtc tacccgcttc ggacgcagac gaggagaggc tcgcagagac tctgcgtgcg     9660

gctgcgactg aagatgctac ccttcggata gtccacgttg cggcgctcga agcaggcgct     9720

acccccagca tgcgttcact gctccgcatg cagcaccgaa tactaggtgg cacgcggcgg     9780

gtgttcaggg cagcggtcgc agcggagtta agaggtccca tttggatagt gacgcgggga     9840

gcacaaagag tggctgacac cgatacagtt gccccgcatc agtcatgcct ctggggattt     9900

gggagggcag catcgctgga gctgccgcac gtttggggtg gcctagcaga tttatcagag     9960

ggcggtgaca atgcggccga tgagtggagt gcgctagtgg accgcattgc cgcaccccac    10020

ggttcagcag ttagggagga ccaactggcg ctgagagaca gggccgtata tacgccaaga    10080

ctggccagac gttctgcgcc cccgagcggg actcccctac atctacgagg ggatggcaca    10140

gtgttaataa caggtgggac tggtacacta ggtaggctat tagcgcgtca cctagtaaca    10200

gagcatgggg tgcggcatct cttactagtt tcaaggagag gcgccgatgc ccctggctcg    10260

gatgaactgc gcgcagaaat agaggactta ggtgccagcg cggagatcgc agcgtgtgat    10320

acagcggatc gcgatgccct atctgcccta ctagatggtc tcccccggcc ccttacgggt    10380

gtcgttcacg ccgctggcgt gttagccgat ggacttgtca ctagcattga cgagcctgcg    10440

gtggaacagg ttctccgagc aaaggtggac gcggcatgga acctacacga actcacagct    10500

aataccgggc tatccttttt cgttcttttc tcatcagcag catcggtcct ggcaggtcca    10560

gggcaaggag tttatgcggc tgcaaatgaa tcgctcaacg cactagctgc gttaaggcga    10620

actaggggtc tgccggccaa ggctctggga tggggcctgt gggccatcgg gcgggcaatc    10680

gcttttgcgg agcagaccgg ggacgccatc gctccagagg aaggagcata cgcttttgaa    10740

actctgttaa ggcataaccg tgcctactcg ggatatgcgc ccgtcattgg atctccctgg    10800

ttgaccgcgt tcgcacagca ttcccccttt gcagaaaaat tccaatcact cggacagaat    10860

cggtcaggga catcgaaatt cttagcggag ctagttgacc tgcctcgtga ggaatggccg    10920

gataggctca ggagactact agagttagtt aggtcccatg ccgccgcggt ctccggttac    10980

ggtagtgcag atcaactgcc ggaaagaaaa gcgttcaagg atttggggtt tgattcgctg    11040

gccgccgttg aactgcgtaa ccggctggga acggctacag gggtacgact gccgtcaacc    11100

ctagtatttg atcacccaac tccgctggcc gtcgctgagc acttaagaga taggctaaca    11160

tccggggaag ataaccctat ccccctatgt caaggcgatg gggaggagat gagcacatgg    11220

ctacgtcgtt ttggaccccc agtcgaacat cgggccaggc tagtgtgttt cccccacgca    11280

ggcgcagcgg cggattcata cttagaccta gcaagagcgt tagcaccaga gatcgatgtt    11340

catgctgttc aataccccgg caggcaagac agaagggacg aggagccatt aggaaccgca    11400

ggtgaaattg cagatgaagt ggcagcggtg ctacgtgcgt cgggagggga tgggcctttt    11460

gcacttttcg gccacagtat gggcgccctc atcgcgtacg agacagcaag gcgattagag    11520

agggaaccgg gagggggacc cttacgttta ttcgtgagcg gacaaacagc gccacgtgtc    11580

catgaacgaa gaactgatct gcccggtgac gatggactcg tggacgagct taggcgactt    11640

ggcacctccg aggcagcgct cgcagacgaa gccctgctgg ctatgtctct cccggtgctc    11700

agggcggatt atagggtgtt aagatcctac gcttgggcgg atggtccccc actacgcgcc    11760

ggtataactg ccctctgcgg tgatgcagac ccactaactg caacagggga tgcggaacgc    11820

tggttacaac attccgtgat tccgggtcgg acacggacat ttcccggtgg gcatttttat    11880

ttaggggaac aagtgaccga ggtggcaggg gctgtccgta gagatttact gagagcaggg    11940

ttagcgggtt ga                                                        11952


<210>  16
<211>  12291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ISS

<400>  16
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg tgccggttga gcagccattt     1860

gtgcatagcc ctgaagatcg ctatcaaccg ttcgcgctga ccgacgtaca gcaagcctac     1920

ctggtggggc gtcagccggg atttgccctg ggcggtgttg gctctcattt cttcgtcgaa     1980

ttcgagattg cagatttaga cttgacccgc ctggaaacgg tttggaaccg tttaatagca     2040

cgccacgata tgttgcgtgc tattgtacgt gacggtcagc aacaggtgct ggaacagacc     2100

ccgccatggg tgatcccggc gcatactctg cacacaccag aagaggcatt acgagttaga     2160

gaaaaactgg ctcatcaggt cttaaaccct gaagtctggc ccgtatttga tctgcaagtg     2220

ggctatgttg acggtatgcc ggcacgtctt tggctctgcc tagataatct attattggac     2280

gggctgagta tgcagattct tctcgccgaa ctggagcacg gatatcgtta ccctcaacag     2340

ctactgcctc ccctgccagt tacctttcgt gattacttgc aacagccgag ccttcagtct     2400

ccgaacccag acagcctggc atggtggcag gctcaactgg atgacatccc gccagcaccg     2460

gctctcccac tgcgttgtct gccacaggaa gtggagactc ctcgattcgc acggcttaat     2520

ggcgctctcg attcaacacg ttggcatcgt ctgaaaaagc gcgcggccga cgcgcacctg     2580

actccgtcgg ccgtgttatt gagtgtttgg tccacagtcc tgtcagcatg gtcggctcag     2640

ccggaattta ctttaaactt gacacttttc gatcgtcgcc ctctgcatcc ccagattaat     2700

caaatcttgg gcgattttac ctcacttatg cttctctcgt ggcatccggg tgaatcctgg     2760

ctgcacagcg cgcagtctct gcaacagcgc ttaagtcaaa acttgaatca ccgtgatgtt     2820

tccgccattc gcgtcatgcg gcagctggcg caacagcaaa atgtcccggc cgtacctatg     2880

cccgtggttt tcacctctgc gctgggcttt gaacaggata acttcctggc ccggcgaaat     2940

ctactgaaac cggtatgggg tattagccag acgccgcaag tctggctgga tcatcagatc     3000

tatgaatctg agggcgaact gcgttttaac tgggatttcg ttgcagctct gtttccggcg     3060

ggtcaggtgg agcgtcagtt cgaacaatac tgcgcattat tgaatcgcat ggctgaggat     3120

gaaagcgggt ggcagctccc gctggcggcc ctggtgcctc ccgttaaaca tgcgggtcag     3180

tgcgccgagc gcagcccgcg tgtttgtcca gaacagtctc aaccgcacat cgcagctgat     3240

gaaagtactg tttccctgat atgtgacgca tttcgtgagg tcgtagggga aagtgtgacc     3300

ccggctgaga actttttcga agcgggagcc acgtccttaa atttggtaca gctgcatgtg     3360

cttctccaac gtcacgaatt ttcaaccctg acgctactgg atttattcac gcacccgtcg     3420

ccagcggccc ttgcggacta tctcgcgggt gtcgccaccg tagaaaaaac gaagaggcct     3480

cggcccgtga gaaggcgtca gcgccggatc cagcacttgc ccttagtagc tgcgcaacct     3540

ggaatatgga tggccgagaa gttatctgaa ctaccatcag cgtggagcgt agcgcattac     3600

gtggagctca ctggtgaggt tgactcgcct cttttggcca gggcggtagt ggctggcctt     3660

gcacaagctg acaccttaag aatgcgtttc acagaggata atggggaagt ttggcaatgg     3720

gtagacgatg cgttaacatt tgagttaccg gaaatcatag acctgcgcac taacatagac     3780

cctcacggga cagctcaggc cttgatgcaa gcggacctgc aacaggacct acgtgtggat     3840

tcggggaagc ctctggtctt ccatcagcta attcaagtag cggacaatcg ctggtactgg     3900

tatcaaaggt accaccactt gcttgtggac gggttcagtt ttccagcgat aaccaggcaa     3960

atagccaaca tttattgcac ttggttgcga ggagagccta cgcccgcatc ccccttcacg     4020

ccattcgcag acgttgttga ggaataccaa cagtatcgcg agagcgaagc gtggcaacgc     4080

gatgcggcat tctgggcgga gcaacgacgg caactaccgc ctcccgcatc cctatcacct     4140

gccccgctcc ccggccggtc cgcgtcagcc gacattctac ggctaaagct ggagttcaca     4200

gatggtgaat ttcgacagct tgctacacaa ctcagcgggg tacaaaggac agacctagcg     4260

ctcgctctgg ctgcattatg gctaggacga ctttgcaatc gaatggacta cgcggcgggt     4320

ttcatattta tgcgccggct cggcagcgca gcgttgaccg caacgggtcc agttttaaat     4380

gttcttcctt tgggaatcca cataggcaac ccaagcttct ctgagcttct caccagggtt     4440

cgcgaggtcg ccttaggcgc gtatgcacac caacatattc cttttgagat gttagtagag     4500

gcactgcaac cagagcgaaa ccttagccat actcctctct tccaagtgat gtttgtcctt     4560

cagaatgcgc ccgcgtccca attagagtta accgggatca ccgcaaaccc aattaaggtt     4620

aaatcaacta ccacgaagtt cgacctaact ttaatcatgc aaaacacagc tagcggatta     4680

gtaggtgttt gggagtacaa cacggattta ttcgacgcgt caacgattga gcgaatgaca     4740

gggcactttg taaccctcct cgagggcgtt atcgccaatc cacaacagcc gatctctcaa     4800

cttcctattt taactacagt ggagcaacag caacttttag tcgagtggaa taacacgcaa     4860

accgactacc ccgctgataa gtgtatacat caattattcg aggaacaggt cgagcgcaca     4920

ccagacgccg ttgctgtcgt ctttgggaat cagcaactca gctatcgaga gatgcgcgaa     4980

caagtggttg cactcgccaa tttattacgt gagcggggag tcaagccagg agactccgtt     5040

gccgtggcct taccacgctc tgttttctta acccttgcac tacacgcgat tgtcgaggca     5100

ggtgccgcct ggctacctct tgacacagga tatcctgacg atagattaaa aatgatgctc     5160

gaggatgcac ggccttccct tctgatcaca acagacgatc aattaccccg cttcagtgac     5220

gtacctaatc tgacctcact ctgttacaac gctcccttga cgcctcaagg gagcgcccct     5280

ttacagctgt ctcaacctca ccatactgca tatatcatct ttacaagtgg ttctacggga     5340

cgccccaagg gagtaatggt tggtcagact gcgattgtaa atcgtctgtt gtggatgcaa     5400

aaccactacc ctttgacggg ggaggacgtt gtagcccaaa agactccttg ctcgttcgat     5460

gtctcagtct gggagttctt ttggccattt atagcagggg ccaaattagt tatggcggag     5520

ccggaagccc accgagaccc acttgcgatg cagcaattct ttgctgagta tggtgtcacc     5580

actacacatt tcgtcccatc gatgttagcg gccttcgtgg cttctcttac tccacaaacg     5640

gctaggcaat cttgtgccac actaaagcaa gtcttctgct ccggcgaggc attacctgca     5700

gacttgtgcc gggaatggca gcaactcaca ggagctccat tgcacaatct atacggaccg     5760

accgaggccg cagtagacgt atcttggtat cctgcgtttg gcgaggagtt agcgcaagta     5820

agaggttcgt cagtaccaat aggatacccc gtatggaaca cggggcttcg gatactggac     5880

gcgatgatgc atccggtccc accaggagtc gcgggcgatt tatacctgac tgggatacag     5940

ctggcccaag gttacctagg gagacctgac cttacggcgt cgaggttcat agcggatccg     6000

tttgctccgg gtgagcgcat gtaccgtacg ggcgacgtcg cgcgatggct agataatggc     6060

gccgtagagt atcttggtag atcagacgat cagttaaaga tacggggaca acgaatagag     6120

cttggggaaa tagaccgggt aatgcaggct ttgccagatg tcgagcaagc ggtggcttcg     6180

tgtgctattg cgcgggagga catacctggg aacaaacacc ttgtagcgta catagttcct     6240

caagaggagc aaacatgcac tgagcgatcg aggtccacac ttacagtttc gttcgtccgg     6300

agtttcctta aggagaaact ccccgaatat atggtaccga gcgcaatagt gattctagac     6360

gctctccccc tgactcctaa tggaaagcta gaccggcggg cgttacccgc ccctgacctg     6420

cactcacaac ttgagacaat tattgctgcg gctttctcga gcctgctcgg gtgcgacgta     6480

caagacgcgg atgctgactt tttcgcgcta ggtggccatt cgctgcttgc catgaagcta     6540

gccgctcagc tttcccgaca agtagcgcgg caggtgacac caggccaagt tatggtagct     6600

tcgactgtcg caaagctcgc aacgatcata gacgcggagt tagataaata cgtcgctcca     6660

aggaacccga tactgccagt agaacagcct tttgtgcact caccggaaga gcggtatcga     6720

ccattcgcgt taacggatgt tcagcaagcc tacctggtcg ggcgccagcc gggatttgcc     6780

ctgggcggtg taggctcgca tttcttcgtg gaattcgaga tcgcagatct cgacatacac     6840

cgcctggaaa aagtgtggaa ccgtttaatt gcacgtcatg atatgttgcg cgctgtggtt     6900

cgtgacggtc agcaacgtgt actggaacag accccgccat gggtcatacc agcacatatt     6960

cttcacagtc ctgaagaggc attacaggtt cgtgatcgtt tagctcacca agtgttgaac     7020

cccgaagtct ggccggtatt tgatctgcag gtgggcttcg ttgacggtat gccggcccgt     7080

ttatggttgt gccttgataa cctgttattg gacgggctga gcatgcagat tcttctctct     7140

gaactggagc atggatatcg ctacccacag caactccctc ccccgttgcc gatcactttt     7200

cgcgattatc ttcagcaacc ggcactccgt accccaaatc ctgactcatt ggcttggtgg     7260

cagacgcaac tggatgacat cccacctgcg cccgccctcc cgctacgttg tctgcctcaa     7320

gatgttgaaa ccccgcgttt cgcgcgtctg tacggcgcaa tggattctgc tcgttggcgt     7380

cgcctgaaac agcgtgcggc cgacgcacat ctgactccgt cagctgtcct actgagcgta     7440

tggtctacag tgctggcagc ttggtcggcg cagccggatt ttactctcaa cctgacatta     7500

ttcgaccggc gaccactgca ccctcagatt aatcaaatcc ttggcgattt tacctcactg     7560

atgttattgt cgtggcatcc gggtgagagt tggctgcagt ccgcgcgtct tctccagcaa     7620

cgcctttcag aatcgctcaa ccaccgtgat gttagcgcca ttcgcgtcat gcggcagctg     7680

gcgagaaggc aaaatgtccc ggccgtaccc atgccggtcg tatttacctc tgcgctgggg     7740

tttgaacagg ataacttcct ggcccgtcgc aatctactga aaccggtgtg gggtatcagt     7800

cagacgccgc aagtttggct ggaccatcag gtctatgaat ccgagggcga actgcgtttt     7860

aactgggatt tcgttgcggc cctgtttccg gacggtcaag tggaacgtca gttcgcgcaa     7920

tactgcgcct tattgaatcg catggcagaa gatgacagct cttggcagtt gccgcttgct     7980

gatctggtgc ccccgttaaa agtgaccgag cggcgagcga gaaggctgcg tccagaacgc     8040

gcccagcctc gtattgcagc tgataagagt tccgttagtc tgatctgtga cacttttcgt     8100

gaggtggttg gggaacccgt ggcaccggct gagaactttt tcgaagcggg agccacatcc     8160

ctcaatctgg ttcagctgca tgtccttctc caacgtcacg aatttgcgac cttaacgcta     8220

ctggatttgt tcacccatcc aagccctgtt gcattggcta actatcttgc gggtgtggcc     8280

ctggaagaga aaacgaagcg cgtgcggccg gttcggcgaa gacagcgtcg cattcagcac     8340

ttgcccttag tagctgcgca acctggaata tggatggccg agaagttatc tgaactacca     8400

tcagcgtgga gcgtagcgca ttacgtggag ctcactggtg aggttgactc gcctcttttg     8460

gccagggcgg tagtggctgg ccttgcacaa gctgacacct taagaatgcg tttcacagag     8520

gataatgggg aagtttggca atgggtagac gatgcgttaa catttgagtt accggaaatc     8580

atagacctgc gcactaacat agaccctcac gggacagctc aggccttgat gcaagcggac     8640

ctgcaacagg acctacgtgt ggattcgggg aagcctctgg tcttccatca gctaattcaa     8700

gtagcggaca atcgctggta ctggtatcaa aggtaccacc acttgcttgt ggacgggttc     8760

agttttccag cgataaccag gcaaatagcc aacatttatt gcacttggtt gcgaggagag     8820

cctacgcccg catccccctt cacgccattc gcagacgttg ttgaggaata ccaacagtat     8880

cgcgagagcg aagcgtggca acgcgatgcg gcattctggg cggagcaacg acggcaacta     8940

ccgcctcccg catccctatc acctgccccg ctccccggcc ggtccgcgtc agccgacatt     9000

ctacggctaa agctggagtt cacagatggt gaatttcgac agcttgctac acaactcagc     9060

ggggtacaaa ggacagacct agcgctcgct ctggctgcat tatggctagg acgactttgc     9120

aatcgaatgg actacgcggc gggtttcata tttatgcgcc ggctcggcag cgcagcgttg     9180

accgcaacgg gtccagtttt aaatgttctt cctttgggaa tccacatagg caacccaagc     9240

ttctctgagc ttctcaccag ggttcgcgag gtcgccttag gcgcgtatgc acaccaacat     9300

attccttttg agatgttagt agaggcactg caaccagagc gaaaccttag ccatactcct     9360

ctcttccaag tgatgtttgt ccttcagaat gcgcccgcgt cccaattaga gttaaccggg     9420

atcaccgcaa acccaattaa ggttaaatca actaccacga agttcgacct aactttaatc     9480

atgcaaaaca cagctagcgg attagtaggt gtttgggagt acaacacgga tttattcgac     9540

gcgtcaacga ttgagcgaat gacagggcac tttgtaaccc tcctcgaggg cgttatcgcc     9600

aatccacaac agccgatctc tcaacttcct attttaacta cagtggagca acagcaactt     9660

ttagtcgagt ggaataacac gcaaaccgac taccccgctg ataagtgtat acatcaatta     9720

ttcgaggaac aggtcgagcg cacaccagac gccgttgctg tcgtctttgg gaatcagcaa     9780

ctcagctatc gagagatgcg cgaacaagtg gttgcactcg ccaatttatt acgtgagcgg     9840

ggagtcaagc caggagactc cgttgccgtg gccttaccac gctctgtttt cttaaccctt     9900

gcactacacg cgattgtcga ggcaggtgcc gcctggctac ctcttgacac aggatatcct     9960

gacgatagat taaaaatgat gctcgaggat gcacggcctt cccttctgat cacaacagac    10020

gatcaattac cccgcttcag tgacgtacct aatctgacct cactctgtta caacgctccc    10080

ttgacgcctc aagggagcgc ccctttacag ctgtctcaac ctcaccatac tgcatatatc    10140

atctttacaa gtggttctac gggacgcccc aagggagtaa tggttggtca gactgcgatt    10200

gtaaatcgtc tgttgtggat gcaaaaccac taccctttga cgggggagga cgttgtagcc    10260

caaaagactc cttgctcgtt cgatgtctca gtctgggagt tcttttggcc atttatagca    10320

ggggccaaat tagttatggc ggagccggaa gcccaccgag acccacttgc gatgcagcaa    10380

ttctttgctg agtatggtgt caccactaca catttcgtcc catcgatgtt agcggccttc    10440

gtggcttctc ttactccaca aacggctagg caatcttgtg ccacactaaa gcaagtcttc    10500

tgctccggcg aggcattacc tgcagacttg tgccgggaat ggcagcaact cacaggagct    10560

ccattgcaca atctatacgg accgaccgag gccgcagtag acgtatcttg gtatcctgcg    10620

tttggcgagg agttagcgca agtaagaggt tcgtcagtac caataggata ccccgtatgg    10680

aacacggggc ttcggatact ggacgcgatg atgcatccgg tcccaccagg agtcgcgggc    10740

gatttatacc tgactgggat acagctggcc caaggttacc tagggagacc tgaccttacg    10800

gcgtcgaggt tcatagcgga tccgtttgct ccgggtgagc gcatgtaccg tacgggcgac    10860

gtcgcgcgat ggctagataa tggcgccgta gagtatcttg gtagatcaga cgatcagtta    10920

aagatacggg gacaacgaat agagcttggg gaaatagacc gggtaatgca ggctttgcca    10980

gatgtcgagc aagcggtggc ttcgtgtgct attgcgcggg aggacatacc tgggaacaaa    11040

caccttgtag cgtacatagt tcctcaagag gagcaaacat gcactgagcg atcgaggtcc    11100

acacttacag tttcgttcgt ccggagtttc cttaaggaga aactccccga atatatggta    11160

ccgagcgcaa tagtgattct agacgctctc cccctgactc ctaatggaaa gctagaccgg    11220

cgggcgttac ccgcccctga cctgcactca caacttgaga caattattgc tgcggctttc    11280

tcgagcctgc tcgggtgcga cgtacaagac gcggatgctg actttttcgc gctaggtggc    11340

cattcgctgc ttgccatgaa gctagccgct cagctttccc gacaagtagc gcggcaggtg    11400

acaccaggcc aagttatggt agcttcgact gtcgcaaagc tcgcaacgat catagacgcg    11460

gagttagata aatacgtcgc tccaaggaac ccgataacat ccggggaaga taaccctatc    11520

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    11580

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    11640

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    11700

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    11760

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    11820

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    11880

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    11940

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    12000

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    12060

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    12120

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    12180

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    12240

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             12291


<210>  17
<211>  11961
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCC

<400>  17
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcgg agagccgttc ccactcgctc ctatgcaaca cgccatgtgg     3240

gtagggcggc acgaccacca acagctcggg ggagtagcag gccatcttta cgtcgagttt     3300

gacggcgcga gagtcgaccc cgatcggttg cgcgctgccg ccacccgact cgccctacgt     3360

caccctatgt tgagggtaca gttcctgcct gacggtacac aaaggatccc tccagccgca     3420

ggctcgcggg actttcccat cagcgttgcg gatcttcgtc acgtagctcc tgacgttgtc     3480

gatcaacggc tcgcgggtat tagagacgca aagtctcatc aacagcttga tggagctgtc     3540

ttcgagttgg ctctcactct cctgccaggt gaaaggacga ggctgcacgt cgacctggat     3600

atgcaagctg ctgacgccat gagctacagg atcctgctgg cggacttggc cgcactatac     3660

gacgggagag agcccccagc actcggttac acgtatagag agtaccgcca ggctattgag     3720

gccgaggaaa cattaccgca acctgttcgc gacgccgata gggactggtg ggcacaaaga     3780

ataccacagc ttccagaccc gcccgcacta ccgacgcgtg ccggtggtga gagagatcgc     3840

cggcgctcga ccagaagatg gcactggtta gacccacaaa caagggacgc cctcttcgca     3900

cgagcacgag ctcgtggcat cacacctgca atgacacttg cggccgcgtt tgcaaatgtc     3960

ctcgcgagat ggtccgcctc ttcccggttc ttactcaatt tgcccctttt ctcgcgccaa     4020

gcgttgcatc cggacgtaga cctcttggta ggtgacttca catcgtcgct gctgttagat     4080

gttgacctag gagatacagt gtctaatctt gctcggaaga accaactgac ttttacggag     4140

gactgggaac accggcattg gagcggagta gagttgctgc gagaactcaa aaggcaacag     4200

cgttacccac acggagcgcc cgtggtgttc acttctaatc ttgggcgcag tttatattct     4260

tctcgggcgg agtccccctt gggagagcct gaatggggaa tttcgcaaac accacaggtt     4320

tggatcgacc atttagcatt tgagcaccat ggggaagtat ggctccaatg ggactcgaac     4380

gacgccctct tcccacctgc tttagtcgag actctgtttg acgcgtactg tcaattgata     4440

aaccagctgt gcgacgatga atccgcatgg caaaagccct tcgcggacat gatgccggcg     4500

agtcagcgtg ctattcgtga gcgggtgaac gctaccggcg caccgatccc ggagggcctc     4560

ttacacgaag ggatttttcg gatcgctctt caacagcctc aggcgctcgc ggtaacggac     4620

atgcggtacc aatggaatag ttatcgagag atgcgggaac aggtcgtcgc tttggcaaat     4680

ctactccgag agcgcggggt caagccaggg gactcagtcg ctgtagcgct tcctcggtca     4740

gtcttcctaa ccttggctct ccacgcgatc gtagaggcgg gtgcggcgtg gcttcccctc     4800

gacacgggct atccggacga tcggttgaag atgatgctag aggatgcacg accctctctg     4860

ttaatcacaa ccgacgatca actccccagg ttctcagacg tccctaatct taccagtcta     4920

tgttacaacg cgcccctcac tccacaaggc agcgctcctt tacaacttag tcagccgcac     4980

cataccgctt atatcatttt tacgtccggt tccacgggca ggccgaaggg tgtaatggtg     5040

ggccaaactg caatagtgaa tagactattg tggatgcaaa accactaccc gcttaccggg     5100

gaggacgtag tggctcaaaa gactccctgc tctttcgatg tcagcgtgtg ggagttcttt     5160

tggcctttta tagccggcgc taaattggtt atggcggagc cggaagctca ccgagaccct     5220

ttggccatgc aacagttctt tgcagagtat ggagtcacaa cgacgcattt cgtcccatcg     5280

atgttagccg cgttcgtagc atcattgacg ccacaaactg cgagacagtc atgtgccaca     5340

cttaagcaag tcttctgctc tggtgaggcc cttcctgcgg acctatgtcg ggaatggcaa     5400

cagcttactg gagccccctt gcacaatctt tacgggccga ctgaggccgc agttgacgta     5460

tcgtggtatc cagcgttcgg ggaggagcta gcccaagtgc gagggtctag tgttccaatt     5520

ggatacccgg tgtggaacac agggttaagg atcctcgacg ccatgatgca tccggtacca     5580

ccaggtgtcg ctggggattt gtacctgact ggcattcaac tggcacaggg ttatctaggg     5640

cggcctgact taacagctag ccgattcata gcagatccat tcgctcccgg agagcggatg     5700

taccgaacag gcgacgtggc acgctggtta gataatggcg ctgtcgagta tcttgggcgg     5760

tcagacgatc agttaaagat acgtggacaa cggattgagc ttggtgaaat agaccgagtt     5820

atgcaggcac taccagatgt cgagcaagcc gtagcctctt gtgccattgc gcgagaagac     5880

attcccggga acaagcactt ggttgcgtac atagtgccgc aagaggagca gacctgcaca     5940

gagcggtcac gttcaactct cacagtttcc ttcgtccgtt ctttcttaaa ggagaaacta     6000

ccagaatata tggtaccgtc cgcgatcgtg atattagacg ctctgccact cacgccaaat     6060

ggaaagttgg atagaagagc tctgcctgct cctgacttgc actcgcaact cctggataaa     6120

tacgttgctc ccagaaaccc aatagagact attatcgcgg cagcattctc ttcattgctt     6180

ggatgcgacg tccaagatgc ggacgcagat ttctttgcgc tcgggggcca tagtctattg     6240

gccatgaagc tcgcagcgca attgtcgaga caggtagcac ggcaagtaac gcccgggcaa     6300

gtcatggtcg cctcgacagt cgcgaaactc gcgaccatta tcgacgctga gctgccagta     6360

gaacagcctt ttgtgcactc accggaagag cggtatcgac cattcgcgtt aacggatgtt     6420

cagcaagcct acctggtcgg gcgccagccg ggatttgccc tgggcggtgt aggctcgcat     6480

ttcttcgtgg aattcgagat cgcagatctc gacatacacc gcctggaaaa agtgtggaac     6540

cgtttaattg cacgtcatga tatgttgcgc gctgtggttc gtgacggtca gcaacgtgta     6600

ctggaacaga ccccgccatg ggtcatacca gcacatattc ttcacagtcc tgaagaggca     6660

ttacaggttc gtgatcgttt agctcaccaa gtgttgaacc ccgaagtctg gccggtattt     6720

gatctgcagg tgggcttcgt tgacggtatg ccggcccgtt tatggttgtg ccttgataac     6780

ctgttattgg acgggctgag catgcagatt cttctctctg aactggagca tggatatcgc     6840

tacccacagc aactccctcc cccgttgccg atcacttttc gcgattatct tcagcaaccg     6900

gcactccgta ccccaaatcc tgactcattg gcttggtggc agacgcaact ggatgacatc     6960

ccacctgcgc ccgccctccc gctacgttgt ctgcctcaag atgttgaaac cccgcgtttc     7020

gcgcgtctgt acggcgcaat ggattctgct cgttggcgtc gcctgaaaca gcgtgcggcc     7080

gacgcacatc tgactccgtc agctgtccta ctgagcgtat ggtctacagt gctggcagct     7140

tggtcggcgc agccggattt tactctcaac ctgacattat tcgaccggcg accactgcac     7200

cctcagatta atcaaatcct tggcgatttt acctcactga tgttattgtc gtggcatccg     7260

ggtgagagtt ggctgcagtc cgcgcgtctt ctccagcaac gcctttcaga atcgctcaac     7320

caccgtgatg ttagcgccat tcgcgtcatg cggcagctgg cgagaaggca aaatgtcccg     7380

gccgtaccca tgccggtcgt atttacctct gcgctggggt ttgaacagga taacttcctg     7440

gcccgtcgca atctactgaa accggtgtgg ggtatcagtc agacgccgca agtttggctg     7500

gaccatcagg tctatgaatc cgagggcgaa ctgcgtttta actgggattt cgttgcggcc     7560

ctgtttccgg acggtcaagt ggaacgtcag ttcgcgcaat actgcgcctt attgaatcgc     7620

atggcagaag atgacagctc ttggcagttg ccgcttgctg atctggtgcc cccgttaaaa     7680

gtgaccgagc ggcgagcgag aaggctgcgt ccagaacgcg cccagcctcg tattgcagct     7740

gataagagtt ccgttagtct gatctgtgac acttttcgtg aggtggttgg ggaacccgtg     7800

gcaccggctg agaacttttt cgaagcggga gccacatccc tcaatctggt tcagctgcat     7860

gtccttctcc aacgtcacga atttgcgacc ttaacgctac tggatttgtt cacccatcca     7920

agccctgttg cattggctaa ctatcttgcg ggtgtggccc tggaagagaa aacgaagcgc     7980

gtgcggccgg ttcggcgaag acagcgtcgc attggagagc cgttcccact cgctcctatg     8040

caacacgcca tgtgggtagg gcggcacgac caccaacagc tcgggggagt agcaggccat     8100

ctttacgtcg agtttgacgg cgcgagagtc gaccccgatc ggttgcgcgc tgccgccacc     8160

cgactcgccc tacgtcaccc tatgttgagg gtacagttcc tgcctgacgg tacacaaagg     8220

atccctccag ccgcaggctc gcgggacttt cccatcagcg ttgcggatct tcgtcacgta     8280

gctcctgacg ttgtcgatca acggctcgcg ggtattagag acgcaaagtc tcatcaacag     8340

cttgatggag ctgtcttcga gttggctctc actctcctgc caggtgaaag gacgaggctg     8400

cacgtcgacc tggatatgca agctgctgac gccatgagct acaggatcct gctggcggac     8460

ttggccgcac tatacgacgg gagagagccc ccagcactcg gttacacgta tagagagtac     8520

cgccaggcta ttgaggccga ggaaacatta ccgcaacctg ttcgcgacgc cgatagggac     8580

tggtgggcac aaagaatacc acagcttcca gacccgcccg cactaccgac gcgtgccggt     8640

ggtgagagag atcgccggcg ctcgaccaga agatggcact ggttagaccc acaaacaagg     8700

gacgccctct tcgcacgagc acgagctcgt ggcatcacac ctgcaatgac acttgcggcc     8760

gcgtttgcaa atgtcctcgc gagatggtcc gcctcttccc ggttcttact caatttgccc     8820

cttttctcgc gccaagcgtt gcatccggac gtagacctct tggtaggtga cttcacatcg     8880

tcgctgctgt tagatgttga cctaggagat acagtgtcta atcttgctcg gaagaaccaa     8940

ctgactttta cggaggactg ggaacaccgg cattggagcg gagtagagtt gctgcgagaa     9000

ctcaaaaggc aacagcgtta cccacacgga gcgcccgtgg tgttcacttc taatcttggg     9060

cgcagtttat attcttctcg ggcggagtcc cccttgggag agcctgaatg gggaatttcg     9120

caaacaccac aggtttggat cgaccattta gcatttgagc accatgggga agtatggctc     9180

caatgggact cgaacgacgc cctcttccca cctgctttag tcgagactct gtttgacgcg     9240

tactgtcaat tgataaacca gctgtgcgac gatgaatccg catggcaaaa gcccttcgcg     9300

gacatgatgc cggcgagtca gcgtgctatt cgtgagcggg tgaacgctac cggcgcaccg     9360

atcccggagg gcctcttaca cgaagggatt tttcggatcg ctcttcaaca gcctcaggcg     9420

ctcgcggtaa cggacatgcg gtaccaatgg aatagttatc gagagatgcg ggaacaggtc     9480

gtcgctttgg caaatctact ccgagagcgc ggggtcaagc caggggactc agtcgctgta     9540

gcgcttcctc ggtcagtctt cctaaccttg gctctccacg cgatcgtaga ggcgggtgcg     9600

gcgtggcttc ccctcgacac gggctatccg gacgatcggt tgaagatgat gctagaggat     9660

gcacgaccct ctctgttaat cacaaccgac gatcaactcc ccaggttctc agacgtccct     9720

aatcttacca gtctatgtta caacgcgccc ctcactccac aaggcagcgc tcctttacaa     9780

cttagtcagc cgcaccatac cgcttatatc atttttacgt ccggttccac gggcaggccg     9840

aagggtgtaa tggtgggcca aactgcaata gtgaatagac tattgtggat gcaaaaccac     9900

tacccgctta ccggggagga cgtagtggct caaaagactc cctgctcttt cgatgtcagc     9960

gtgtgggagt tcttttggcc ttttatagcc ggcgctaaat tggttatggc ggagccggaa    10020

gctcaccgag accctttggc catgcaacag ttctttgcag agtatggagt cacaacgacg    10080

catttcgtcc catcgatgtt agccgcgttc gtagcatcat tgacgccaca aactgcgaga    10140

cagtcatgtg ccacacttaa gcaagtcttc tgctctggtg aggcccttcc tgcggaccta    10200

tgtcgggaat ggcaacagct tactggagcc cccttgcaca atctttacgg gccgactgag    10260

gccgcagttg acgtatcgtg gtatccagcg ttcggggagg agctagccca agtgcgaggg    10320

tctagtgttc caattggata cccggtgtgg aacacagggt taaggatcct cgacgccatg    10380

atgcatccgg taccaccagg tgtcgctggg gatttgtacc tgactggcat tcaactggca    10440

cagggttatc tagggcggcc tgacttaaca gctagccgat tcatagcaga tccattcgct    10500

cccggagagc ggatgtaccg aacaggcgac gtggcacgct ggttagataa tggcgctgtc    10560

gagtatcttg ggcggtcaga cgatcagtta aagatacgtg gacaacggat tgagcttggt    10620

gaaatagacc gagttatgca ggcactacca gatgtcgagc aagccgtagc ctcttgtgcc    10680

attgcgcgag aagacattcc cgggaacaag cacttggttg cgtacatagt gccgcaagag    10740

gagcagacct gcacagagcg gtcacgttca actctcacag tttccttcgt ccgttctttc    10800

ttaaaggaga aactaccaga atatatggta ccgtccgcga tcgtgatatt agacgctctg    10860

ccactcacgc caaatggaaa gttggataga agagctctgc ctgctcctga cttgcactcg    10920

caactcctgg ataaatacgt tgctcccaga aacccaatag agactattat cgcggcagca    10980

ttctcttcat tgcttggatg cgacgtccaa gatgcggacg cagatttctt tgcgctcggg    11040

ggccatagtc tattggccat gaagctcgca gcgcaattgt cgagacaggt agcacggcaa    11100

gtaacgcccg ggcaagtcat ggtcgcctcg acagtcgcga aactcgcgac cattatcgac    11160

gctgagacat ccggggaaga taaccctatc cccctatgtc aaggcgatgg ggaggagatg    11220

agcacatggc tacgtcgttt tggaccccca gtcgaacatc gggccaggct agtgtgtttc    11280

ccccacgcag gcgcagcggc ggattcatac ttagacctag caagagcgtt agcaccagag    11340

atcgatgttc atgctgttca ataccccggc aggcaagaca gaagggacga ggagccatta    11400

ggaaccgcag gtgaaattgc agatgaagtg gcagcggtgc tacgtgcgtc gggaggggat    11460

gggccttttg cacttttcgg ccacagtatg ggcgccctca tcgcgtacga gacagcaagg    11520

cgattagaga gggaaccggg agggggaccc ttacgtttat tcgtgagcgg acaaacagcg    11580

ccacgtgtcc atgaacgaag aactgatctg cccggtgacg atggactcgt ggacgagctt    11640

aggcgacttg gcacctccga ggcagcgctc gcagacgaag ccctgctggc tatgtctctc    11700

ccggtgctca gggcggatta tagggtgtta agatcctacg cttgggcgga tggtccccca    11760

ctacgcgccg gtataactgc cctctgcggt gatgcagacc cactaactgc aacaggggat    11820

gcggaacgct ggttacaaca ttccgtgatt ccgggtcgga cacggacatt tcccggtggg    11880

catttttatt taggggaaca agtgaccgag gtggcagggg ctgtccgtag agatttactg    11940

agagcagggt tagcgggttg a                                              11961


<210>  18
<211>  13284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCH

<400>  18
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcgg agagccgttc ccactcgctc ctatgcaaca cgccatgtgg     3240

gtagggcggc acgaccacca acagctcggg ggagtagcag gccatcttta cgtcgagttt     3300

gacggcgcga gagtcgaccc cgatcggttg cgcgctgccg ccacccgact cgccctacgt     3360

caccctatgt tgagggtaca gttcctgcct gacggtacac aaaggatccc tccagccgca     3420

ggctcgcggg actttcccat cagcgttgcg gatcttcgtc acgtagctcc tgacgttgtc     3480

gatcaacggc tcgcgggtat tagagacgca aagtctcatc aacagcttga tggagctgtc     3540

ttcgagttgg ctctcactct cctgccaggt gaaaggacga ggctgcacgt cgacctggat     3600

atgcaagctg ctgacgccat gagctacagg atcctgctgg cggacttggc cgcactatac     3660

gacgggagag agcccccagc actcggttac acgtatagag agtaccgcca ggctattgag     3720

gccgaggaaa cattaccgca acctgttcgc gacgccgata gggactggtg ggcacaaaga     3780

ataccacagc ttccagaccc gcccgcacta ccgacgcgtg ccggtggtga gagagatcgc     3840

cggcgctcga ccagaagatg gcactggtta gacccacaaa caagggacgc cctcttcgca     3900

cgagcacgag ctcgtggcat cacacctgca atgacacttg cggccgcgtt tgcaaatgtc     3960

ctcgcgagat ggtccgcctc ttcccggttc ttactcaatt tgcccctttt ctcgcgccaa     4020

gcgttgcatc cggacgtaga cctcttggta ggtgacttca catcgtcgct gctgttagat     4080

gttgacctag gagatacagt gtctaatctt gctcggaaga accaactgac ttttacggag     4140

gactgggaac accggcattg gagcggagta gagttgctgc gagaactcaa aaggcaacag     4200

cgttacccac acggagcgcc cgtggtgttc acttctaatc ttgggcgcag tttatattct     4260

tctcgggcgg agtccccctt gggagagcct gaatggggaa tttcgcaaac accacaggtt     4320

tggatcgacc atttagcatt tgagcaccat ggggaagtat ggctccaatg ggactcgaac     4380

gacgccctct tcccacctgc tttagtcgag actctgtttg acgcgtactg tcaattgata     4440

aaccagctgt gcgacgatga atccgcatgg caaaagccct tcgcggacat gatgccggcg     4500

agtcagcgtg ctattcgtga gcgggtgaac gctaccggcg caccgatccc ggagggcctc     4560

ttacacgaag ggatttttcg gatcgctctt caacagcctc aggcgctcgc ggtaacggac     4620

atgcggtacc aatggaatag ttatcgagag atgcgggaac aggtcgtcgc tttggcaaat     4680

ctactccgag agcgcggggt caagccaggg gactcagtcg ctgtagcgct tcctcggtca     4740

gtcttcctaa ccttggctct ccacgcgatc gtagaggcgg gtgcggcgtg gcttcccctc     4800

gacacgggct atccggacga tcggttgaag atgatgctag aggatgcacg accctctctg     4860

ttaatcacaa ccgacgatca actccccagg ttctcagacg tccctaatct taccagtcta     4920

tgttacaacg cgcccctcac tccacaaggc agcgctcctt tacaacttag tcagccgcac     4980

cataccgctt atatcatttt tacgtccggt tccacgggca ggccgaaggg tgtaatggtg     5040

ggccaaactg caatagtgaa tagactattg tggatgcaaa accactaccc gcttaccggg     5100

gaggacgtag tggctcaaaa gactccctgc tctttcgatg tcagcgtgtg ggagttcttt     5160

tggcctttta tagccggcgc taaattggtt atggcggagc cggaagctca ccgagaccct     5220

ttggccatgc aacagttctt tgcagagtat ggagtcacaa cgacgcattt cgtcccatcg     5280

atgttagccg cgttcgtagc atcattgacg ccacaaactg cgagacagtc atgtgccaca     5340

cttaagcaag tcttctgctc tggtgaggcc cttcctgcgg acctatgtcg ggaatggcaa     5400

cagcttactg gagccccctt gcacaatctt tacgggccga ctgaggccgc agttgacgta     5460

tcgtggtatc cagcgttcgg ggaggagcta gcccaagtgc gagggtctag tgttccaatt     5520

ggatacccgg tgtggaacac agggttaagg atcctcgacg ccatgatgca tccggtacca     5580

ccaggtgtcg ctggggattt gtacctgact ggcattcaac tggcacaggg ttatctaggg     5640

cggcctgact taacagctag ccgattcata gcagatccat tcgctcccgg agagcggatg     5700

taccgaacag gcgacgtggc acgctggtta gataatggcg ctgtcgagta tcttgggcgg     5760

tcagacgatc agttaaagat acgtggacaa cggattgagc ttggtgaaat agaccgagtt     5820

atgcaggcac taccagatgt cgagcaagcc gtagcctctt gtgccattgc gcgagaagac     5880

attcccggga acaagcactt ggttgcgtac atagtgccgc aagaggagca gacctgcaca     5940

gagcggtcac gttcaactct cacagtttcc ttcgtccgtt ctttcttaaa ggagaaacta     6000

ccagaatata tggtaccgtc cgcgatcgtg atattagacg ctctgccact cacgccaaat     6060

ggaaagttgg atagaagagc tctgcctgct cctgacttgc actcgcaact cctggataaa     6120

tacgttgctc ccagaaaccc aatagagact attatcgcgg cagcattctc ttcattgctt     6180

ggatgcgacg tccaagatgc ggacgcagat ttctttgcgc tcgggggcca tagtctattg     6240

gccatgaagc tcgcagcgca attgtcgaga caggtagcac ggcaagtaac gcccgggcaa     6300

gtcatggtcg cctcgacagt cgcgaaactc gcgaccatta tcgacgctga gcctggaatt     6360

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     6420

atagtatcca tggcttgccg gttacccggt ggtgtgaata ccccacagag actatgggaa     6480

ttattacgtg aagggggaga aaccctcagt ggcttcccta ccgaccgagg gtgggacctc     6540

gcgaggttgc atcacccaga cccagacaac cccggtacgt catacgttga taaaggggga     6600

ttcctggacg atgcggcagg gtttgacgca gaatttttcg gtgtgagccc cagagaagca     6660

gcggctatgg acccgcagca gagattactc ctcgaaacca gctgggagtt agtcgagaat     6720

gcagggattg atccacatag cctaaggggg accgccactg gtgtcttcct cggcgttgcc     6780

aagtttgggt atggcgagga tacggcagct gccgaagacg tcgaggggta ctctgtcact     6840

ggtgtagccc cggcagtggc gtcgggcaga attagttaca cgatggggtt ggaagggccg     6900

tctatttcgg ttgataccgc ctgttcctcc agtctggttg cactccacct tgcagtcgag     6960

tcgctccgga aaggagaaag cagtatggcc gtggtcgggg gagcggcggt gatggccaca     7020

ccgggtgtgt ttgtggattt ttcccgacag agagccttgg ccgcggatgg gcgttcaaag     7080

gcgttcggag caggtgcaga cgggtttgga tttagcgaag gtgtgacact ggttctccta     7140

gaaagattaa gtgaagcccg gcgtaacggc catgaggtgc tggcagttgt tagaggttcc     7200

gcattaaacc aggacggggc ttcgaacggg ctgagcgccc cctcgggccc ggcacagaga     7260

agagtgatac gccaagcact cgaatcgtgt ggcctagaac caggtgacgt tgacgcggtg     7320

gaagcgcacg ggacaggaac tgcgttaggg gacccgatag aagcaaacgc cttgctggac     7380

acttatggta gagatcgtga tgcggatcga cccctctggt taggaagtgt taagtcaaat     7440

ataggacaca ctcaggcagc ggcgggagta actgggctgc tcaaagtagt cctagcctta     7500

cgcaatgggg aactacccgc caccctacat gtcgaggaac cgacaccgca tgtggattgg     7560

tcgagcgggg gagttgctct cttggcgggt aatcagccgt ggcgaagagg tgaacgaacc     7620

cgtagagccg ccgtgtccgc attcgggatc agtggtacga acgcgcacgt gattgtggaa     7680

gaagctccac aagaggtgag accagcgccc ggtcaaggac tctcgcccgc ggtgtcaacc     7740

ttggtagtgg cgggtaaaac tatgcagcgt gtttcggcaa ccgccggtat gctcgcagat     7800

tggatggaag gcccaggtgc agatgtggcg ctggcggacg tggcgcacac gttaaatcat     7860

caccgttcac ggcaaccaaa gttcggtacg gtggtggcca gggaccggac acaggcaatc     7920

gccggactaa gagcgctggc ggcgggtcag cacgccccag gggttgttaa ccctgctgaa     7980

ggaagtccag gtccagggac ggtgttcgtg tttcctggcc aggggtccca gcgtgcaggc     8040

atgggggagg agttggctgc ggctttcccc gtgtttgcca gaatccacca gcaagtgtgg     8100

gatttactcg atgttcctga tctcgacgtt aacgaaacgg ggtacgcaca accagcactc     8160

ttcgcactcc aagtggcgct gtttgggctc ctcgaatcat ggggagtacg gccggatgcc     8220

gtggtcgggc atagtgtagg ggaattagcg gcagggtacg tttccgggct ttggagtctt     8280

gaggatgctt gcacgctcgt gtcggcgaga gcccgtctaa tgcaagcctt accggcaggt     8340

ggtgttatgg cggcagttcc agtgtccgaa gacgaagcac gggctgtgtt gggggaagga     8400

gtcgaaatag ctgcggtcaa cggtccgtcg agcgtggttc taagcggtga tgaagcagca     8460

gtgctccagg ccgcggaagg gttaggcaag tggacgcgat taccgacctc gcatgcattc     8520

cattctgctc gtatggaacc aatgctggaa gagtttagag cagtggcgga aggtctaaca     8580

tacaggactc cccaggtggc aatggccgcc ggagaccagg ttatgaccgc tgaatactgg     8640

gtgcgtcagg ttagggatac agttcgtttt ggcgagcaag ttgcctcgtt cgaggatgct     8700

gtattcgtgg aattgggagc agatcgctct cttgcacggc tagtcgatgg tatcgcgatg     8760

ttgcacgggg atcatgaggc acaggctggt atgcggagag aacaaccctt gcccttaggt     8820

ttacgaagat tgctaaccga cctgcataac gctggtgctg ccgtcgattt tagtgttttg     8880

tgcccacaag gtcgtctggt tgacgcaccg ttaccagcct ggtcacaccg gtttctcttc     8940

tatgaccggg aaggagtgga caatagatca ccagggggaa gcacagtggc ggtccacccg     9000

cttttactag ccgcggtgga tgtgccgggc cacggtggag cggttttcac gggtagactc     9060

tcgactgacg agcaaccgtg gttagcggag cacgttgtcg ggggaagaac cctagttcct     9120

ggttctgttt tagtcgatct agccttagcg gcaggcgaag acgtagggct accggtgtta     9180

gaagaattag tattgcagag gccgctggtg cttgccggcg cgggagcact cctacggatg     9240

tcggtcgggg caccagacga gagcggtaga agaactatcg atgttcacgc agctgaagac     9300

gtcgccgatt tagcagatgc ccaatggtcc cagcacgcca ccgggacttt agcccaaggg     9360

gtagcggcgg ggcccaggga cacagagcaa tggcccccag aggatgccgt ccggattcca     9420

ttagacgacc attatgatgg tctcgcggaa cagggttatg agtacggtcc gtcgtttcag     9480

gcgctagtgg cctacgtggc ggaggatgcg actgcgacaa tgttagcgga agtcgcgctt     9540

ccgggcagca ttagatcgca acaaggtcta tacgccatcc atcccgcact gctggacgct     9600

tgttttcaat ctgtcggagc ccacccagac agtcaatccg tcgggtcagg tctactcgta     9660

cccctcggtg ttcggagagt tcgtgcgtac gcacccgtaa ggaccgcccg ttattgttac     9720

acccgcgtca cgaaagttga actagctggg gttgaggccg acatcgacgt tctggatgct     9780

cacggcacag tgcttctagc cgtgtgcggt cttcgtatcg ggaccggagt gagcgagagg     9840

gacaaacaca acagagttct caatgagcgc ctactcacca tcgaatggca tcagcgtgaa     9900

ctaccagaaa tggacccctc gggtgccggg aagtggctcc taatctcgga ctgtgcagca     9960

tccgatgtca ccgctacacg actggctgat gccttccggg agcacagcgc tgcgtgcact    10020

accatgcggt ggccacttca cgatgatcaa ctagcagccg ccgaccaact ccgggaccag    10080

gtgggttcag atgagttttc tggcgtggta gtactaacag ggccaaacac agggacccct    10140

catcagggtt ccgcagaccg tggcgccgag tacgttaggc ggttagttgg aatcgctcgt    10200

gaacttagcg atcttcccgg agcggttccc cgtatgtatg tcgtcacaag gggagcgcag    10260

agagtccttg ccgatgattg tgttaattta gaacagggag ggctcagagg tctgctgagg    10320

accatcggtg ctgagcaccc acatctccgc gccacccaaa ttgatgttga tgagcagaca    10380

ggagtagagc agctggcgcg acaactccta gctacatcgg aggaagacga gacagcctgg    10440

agggacaacg aatggtacgt tgcgaggtta tgccccacac ccctgaggcc acaggaacgt    10500

aggacaatag tggcggacca tcaacagtct ggtatgcggt tacaaatacg tacgcccggt    10560

gcaatcgata gtgtggcctt tgaacccgca cccgatgtag agcaaccctt acgggcgggt    10620

gaagttcggg ttgacgttag agcaaccggt gttaatttcc gtgacgttct actcgctctc    10680

gggatgtatc cccagaaagc tgacatgggg acagaagcag ctggtgttgt aacagcagtg    10740

ggacctgatg tcgatgcgtt tgcgcctggt gatagagttc tagggctatt ccaaggggca    10800

tttgctccaa ttgcggtgac tgaccatcgt ttactggcac gggtgccaga cgggtggtca    10860

gatgccgatg cggcggcggt gccaatagct tacacgacag cacattatgc gctgcacgac    10920

ctggcggggt tgcgggcggg gcaatctgtc ctgatacacg cggcagcggg tggtgttggt    10980

atggccgctg ttgcactggc acggagggcc ggcgcagaag ttctggctac cgcaggacct    11040

gcaaaacacg gtacgctacg ggcattaggg ctagatgatg aacacatcgc ttcgagtcgg    11100

gagaccgggt tcgcgcgtaa gttccgagag cggactgggg gacgaggagt ggacgtcgtt    11160

ctaaacagct tgaccggcga actattagac gagtccgcgg atctcctcgc ggaggacgga    11220

gtcttcgtgg aaatgggaaa gactgatctg cgcgatgcag gggactttcg tgggcgctac    11280

gccccgtttg atctagggga agcaggcgat gacaggctcg gggaaattct acgtgaggtg    11340

gtgggactgc tcggtgcagg ggaactcgac cgactccctg ttagcgcgtg ggaattgggg    11400

ataccccaga cggggaagtc gttagtgacg ctgccacccg aacaagcgca agttttcaga    11460

ccagacggca ctgtattgat caccggggga acgggaacgt taggtcggct gctggcccgt    11520

catctggtta cagagcacgg ggtgcgtcac ctgctgctag tgtcgaggag aggagcagat    11580

gcccctggat cggacgagct gagggccgaa atcgaggatc tcggagcatc agcggaaatt    11640

gcagcatgtg atacagccga tcgagacgct ctcagcgcgt tgctagatgg actgccgagg    11700

ccactgaccg gagtagttca cgccgcggga gtcctcgctg acggtctggt tacatccatc    11760

gacgagcccg cagtcgaaca agttctccgt gcaaaagttg atgcggcctg gaacctgcac    11820

gagctaactg cgaacaccgg tctcagcttt ttcgtgctgt tctcgtcagc cgcaagtgtg    11880

ttagcggggc cggggcaggg agtatatgcg gcagcgaacg aatctttaaa cgctctggcc    11940

gctctgcgta ggactagggg tttacccgca aaagcattgg gatggggatt atgggcgata    12000

gggcgtgcaa tagcatttgc cgagcagacc ggtgacgcaa tcgccccgga ggaaggcgcg    12060

tacgccttcg agacactact cagacataac agggcgtact cgggttacgc tcccgtgata    12120

gggtcaccat ggctgactgc gttcgcccaa cattcgccct ttgcggagaa gttccagtcc    12180

ctggggcaaa atagatccgg gacgtctaag tttctggcag aattagtcga tctgccaaga    12240

gaagaatggc cagatcggtt acgtcgtcta ttagaactgg tgaggtctca tgctgccgca    12300

gtttcggggt atggatcggc agaccaatta ccagaaagaa aagcattcaa agacctcgga    12360

ttcgattcac tggcagcagt cgaactaaga aatcgtctag ggaccgcgac aggcgtccgg    12420

ctgcccagta ctctggtgtt cgaccaccca accccacttg cggttgcgga acatctacgt    12480

gatcgtctaa catccgggga agataaccct atccccctat gtcaaggcga tggggaggag    12540

atgagcacat ggctacgtcg ttttggaccc ccagtcgaac atcgggccag gctagtgtgt    12600

ttcccccacg caggcgcagc ggcggattca tacttagacc tagcaagagc gttagcacca    12660

gagatcgatg ttcatgctgt tcaatacccc ggcaggcaag acagaaggga cgaggagcca    12720

ttaggaaccg caggtgaaat tgcagatgaa gtggcagcgg tgctacgtgc gtcgggaggg    12780

gatgggcctt ttgcactttt cggccacagt atgggcgccc tcatcgcgta cgagacagca    12840

aggcgattag agagggaacc gggaggggga cccttacgtt tattcgtgag cggacaaaca    12900

gcgccacgtg tccatgaacg aagaactgat ctgcccggtg acgatggact cgtggacgag    12960

cttaggcgac ttggcacctc cgaggcagcg ctcgcagacg aagccctgct ggctatgtct    13020

ctcccggtgc tcagggcgga ttatagggtg ttaagatcct acgcttgggc ggatggtccc    13080

ccactacgcg ccggtataac tgccctctgc ggtgatgcag acccactaac tgcaacaggg    13140

gatgcggaac gctggttaca acattccgtg attccgggtc ggacacggac atttcccggt    13200

gggcattttt atttagggga acaagtgacc gaggtggcag gggctgtccg tagagattta    13260

ctgagagcag ggttagcggg ttga                                           13284


<210>  19
<211>  11631
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCO

<400>  19
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcgg agagccgttc ccactcgctc ctatgcaaca cgccatgtgg     3240

gtagggcggc acgaccacca acagctcggg ggagtagcag gccatcttta cgtcgagttt     3300

gacggcgcga gagtcgaccc cgatcggttg cgcgctgccg ccacccgact cgccctacgt     3360

caccctatgt tgagggtaca gttcctgcct gacggtacac aaaggatccc tccagccgca     3420

ggctcgcggg actttcccat cagcgttgcg gatcttcgtc acgtagctcc tgacgttgtc     3480

gatcaacggc tcgcgggtat tagagacgca aagtctcatc aacagcttga tggagctgtc     3540

ttcgagttgg ctctcactct cctgccaggt gaaaggacga ggctgcacgt cgacctggat     3600

atgcaagctg ctgacgccat gagctacagg atcctgctgg cggacttggc cgcactatac     3660

gacgggagag agcccccagc actcggttac acgtatagag agtaccgcca ggctattgag     3720

gccgaggaaa cattaccgca acctgttcgc gacgccgata gggactggtg ggcacaaaga     3780

ataccacagc ttccagaccc gcccgcacta ccgacgcgtg ccggtggtga gagagatcgc     3840

cggcgctcga ccagaagatg gcactggtta gacccacaaa caagggacgc cctcttcgca     3900

cgagcacgag ctcgtggcat cacacctgca atgacacttg cggccgcgtt tgcaaatgtc     3960

ctcgcgagat ggtccgcctc ttcccggttc ttactcaatt tgcccctttt ctcgcgccaa     4020

gcgttgcatc cggacgtaga cctcttggta ggtgacttca catcgtcgct gctgttagat     4080

gttgacctag gagatacagt gtctaatctt gctcggaaga accaactgac ttttacggag     4140

gactgggaac accggcattg gagcggagta gagttgctgc gagaactcaa aaggcaacag     4200

cgttacccac acggagcgcc cgtggtgttc acttctaatc ttgggcgcag tttatattct     4260

tctcgggcgg agtccccctt gggagagcct gaatggggaa tttcgcaaac accacaggtt     4320

tggatcgacc atttagcatt tgagcaccat ggggaagtat ggctccaatg ggactcgaac     4380

gacgccctct tcccacctgc tttagtcgag actctgtttg acgcgtactg tcaattgata     4440

aaccagctgt gcgacgatga atccgcatgg caaaagccct tcgcggacat gatgccggcg     4500

agtcagcgtg ctattcgtga gcgggtgaac gctaccggcg caccgatccc ggagggcctc     4560

ttacacgaag ggatttttcg gatcgctctt caacagcctc aggcgctcgc ggtaacggac     4620

atgcggtacc aatggaatag ttatcgagag atgcgggaac aggtcgtcgc tttggcaaat     4680

ctactccgag agcgcggggt caagccaggg gactcagtcg ctgtagcgct tcctcggtca     4740

gtcttcctaa ccttggctct ccacgcgatc gtagaggcgg gtgcggcgtg gcttcccctc     4800

gacacgggct atccggacga tcggttgaag atgatgctag aggatgcacg accctctctg     4860

ttaatcacaa ccgacgatca actccccagg ttctcagacg tccctaatct taccagtcta     4920

tgttacaacg cgcccctcac tccacaaggc agcgctcctt tacaacttag tcagccgcac     4980

cataccgctt atatcatttt tacgtccggt tccacgggca ggccgaaggg tgtaatggtg     5040

ggccaaactg caatagtgaa tagactattg tggatgcaaa accactaccc gcttaccggg     5100

gaggacgtag tggctcaaaa gactccctgc tctttcgatg tcagcgtgtg ggagttcttt     5160

tggcctttta tagccggcgc taaattggtt atggcggagc cggaagctca ccgagaccct     5220

ttggccatgc aacagttctt tgcagagtat ggagtcacaa cgacgcattt cgtcccatcg     5280

atgttagccg cgttcgtagc atcattgacg ccacaaactg cgagacagtc atgtgccaca     5340

cttaagcaag tcttctgctc tggtgaggcc cttcctgcgg acctatgtcg ggaatggcaa     5400

cagcttactg gagccccctt gcacaatctt tacgggccga ctgaggccgc agttgacgta     5460

tcgtggtatc cagcgttcgg ggaggagcta gcccaagtgc gagggtctag tgttccaatt     5520

ggatacccgg tgtggaacac agggttaagg atcctcgacg ccatgatgca tccggtacca     5580

ccaggtgtcg ctggggattt gtacctgact ggcattcaac tggcacaggg ttatctaggg     5640

cggcctgact taacagctag ccgattcata gcagatccat tcgctcccgg agagcggatg     5700

taccgaacag gcgacgtggc acgctggtta gataatggcg ctgtcgagta tcttgggcgg     5760

tcagacgatc agttaaagat acgtggacaa cggattgagc ttggtgaaat agaccgagtt     5820

atgcaggcac taccagatgt cgagcaagcc gtagcctctt gtgccattgc gcgagaagac     5880

attcccggga acaagcactt ggttgcgtac atagtgccgc aagaggagca gacctgcaca     5940

gagcggtcac gttcaactct cacagtttcc ttcgtccgtt ctttcttaaa ggagaaacta     6000

ccagaatata tggtaccgtc cgcgatcgtg atattagacg ctctgccact cacgccaaat     6060

ggaaagttgg atagaagagc tctgcctgct cctgacttgc actcgcaact cctggataaa     6120

tacgttgctc ccagaaaccc aatagagact attatcgcgg cagcattctc ttcattgctt     6180

ggatgcgacg tccaagatgc ggacgcagat ttctttgcgc tcgggggcca tagtctattg     6240

gccatgaagc tcgcagcgca attgtcgaga caggtagcac ggcaagtaac gcccgggcaa     6300

gtcatggtcg cctcgacagt cgcgaaactc gcgaccatta tcgacgctga gcctggaatt     6360

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     6420

atcgtttcga tggcatgtcg tttaccggga ggagtcaata cgccccaacg gctctgggaa     6480

ttactacggg agggtggtga aaccttgtcc gggttcccaa cggaccgtgg ctgggaccta     6540

gcacggcttc accaccctga tccggacaac cccggaacga gctacgttga taagggtgga     6600

tttctcgacg acgcggcggg tttcgacgca gagtttttcg gggtttcacc aagggaagct     6660

gccgctatgg accctcagca acgattactt ttagagacct cgtgggagct agttgaaaat     6720

gcgggcatag atccacatag cctgcgaggg acagcgacag gggtgttcct aggagttgcg     6780

aagtttggtt atggtgagga cacagcagca gcggaagatg ttgaaggtta ttcagttacc     6840

ggtgttgctc ccgctgtggc atctggccgc atatcctaca ctatgggttt agaaggtcct     6900

tccatctcgg tcgataccgc atgctcaagc tcgctagtcg cgcttcatct agccgtagag     6960

tccctccgaa agggtgagtc atctatggcg gtggtgggtg gtgcagccgt tatggcgact     7020

cctggggtat ttgttgattt ttcacgccaa cgggcgcttg ccgcagacgg ccgttccaaa     7080

gcgttcgggg caggtgcaga tggttttggt ttcagcgagg gagtcacgct ggttctacta     7140

gagcgtttaa gtgaggcgcg tcgtaacggt catgaagttc tagctgtagt gcgcgggtcc     7200

gcgttaaacc aggacggagc gagcaacgga ctttcagcac cctccggccc tgcgcaacgt     7260

agagtaataa ggcaagcgct cgaatcgtgt gggcttgaac cgggggatgt tgacgcggtt     7320

gaggcgcatg gtactggtac agcactaggt gacccaatag aggccaatgc gctgttggac     7380

acttacgggc gagaccgtga tgcggatcgt ccactttggt tggggtccgt taagagcaat     7440

attgggcaca ctcaagctgc ggccggggtt acaggactgc tgaaggttgt gttagcactg     7500

cgcaatggtg agctacctgc aacgttacat gtcgaggaac caactccaca cgtcgattgg     7560

tcctcaggtg gtgtcgcatt actggcgggt aatcaaccat ggcgaagggg agaaaggacc     7620

agaagggcgg cagtgagcgc ctttggtatc tccggtacaa atgctcacgt gatagtggaa     7680

gaggcgcctc aggaagttcg acccgcccct ggccaagggc tgtcgccagc cgtgtccacg     7740

ttagttgttg caggtaaaac catgcagcgt gtaagtgcga cagctggaat gcttgcagac     7800

tggatggagg gtcctggggc cgatgttgca ttggcggatg tggcccatac cctgaaccat     7860

caccgatcaa gacagcccaa gttcgggacg gttgtagcgc gtgacaggac tcaggcgata     7920

gctgggctcc gtgcattggc ggctggtcaa catgctcctg gggtcgtcaa cccagctgaa     7980

ggttccccag gaccaggcac cgtgttcgtt tttcccggtc aaggttcgca gagggcaggg     8040

atgggggagg aactcgcggc agcctttcct gtcttcgctc gaatacatca gcaagtttgg     8100

gacctcctag atgttcccga cctcgacgtt aatgaaaccg ggtacgccca accagcgctg     8160

ttcgcgcttc aggtcgcgct ctttggcctt ctggagtcgt ggggtgttag gccagatgca     8220

gtggtagggc actcagttgg tgagctggcc gcggggtacg tgtccggtct ttggtcacta     8280

gaggacgcct gcacactagt ctcagcaaga gcgcgcctaa tgcaggcact gcctgctgga     8340

ggggtgatgg cggcagtccc cgtctccgag gatgaggcgc gggccgtcct gggcgaggga     8400

gttgaaattg cggctgtgaa tggaccctcg tccgttgtgc tctcagggga cgaggcggca     8460

gtcttacagg ccgccgaagg tctaggtaag tggacgcgac tgccgaccag ccatgctttt     8520

cactcagcga gaatggaacc catgctagaa gagtttcggg ccgtagcaga gggtctgacc     8580

tatcgtaccc ctcaagtagc tatggctgct ggggatcagg tgatgacagc agaatattgg     8640

gtgcggcagg ttcgggacac agttcgcttc ggggagcaag tagcgtcatt cgaggatgcg     8700

gtgtttgttg agttaggcgc tgacagaagt ctagcgcgtt tggtggacgg catcgccatg     8760

ctgcacggtg accacgaagc gcaggccgcg gaccataggc aaatcaccga agcggttgcg     8820

gatgcttacg tcttaggcca ccttccggat tttgcggcgc tgcggcggcc tcacgcacga     8880

aagttggact taccaactta tcccttcgag cgtagacagt actggttcag agatgcgcgt     8940

gagaggccgg aacaacccag agataccggc ggacctcgca cagaagcagt ccgtctgtta     9000

gaggatggta ggattgaaga attagctgca cttttgggag gggccagtga tgaccaacac     9060

acattacagg tgctgactaa gttggcggcg caacataacc aacaacgaac aacccggtca     9120

atcgctgacg acaggtacga aataaggtgg gaccgatcga cttccccact atccggagca     9180

gatgttgacc aagcggggag ctggatcgtg gtgtcagatg acgcagatgc cgttcccccg     9240

ctagtggact tgctggctgc acgtaacgag ccccatcagg ttgttggtct acccgcttcg     9300

gacgcagacg aggagaggct cgcagagact ctgcgtgcgg ctgcgactga agatgctacc     9360

cttcggatag tccacgttgc ggcgctcgaa gcaggcgcta cccccagcat gcgttcactg     9420

ctccgcatgc agcaccgaat actaggtggc acgcggcggg tgttcagggc agcggtcgca     9480

gcggagttaa gaggtcccat ttggatagtg acgcggggag cacaaagagt ggctgacacc     9540

gatacagttg ccccgcatca gtcatgcctc tggggatttg ggagggcagc atcgctggag     9600

ctgccgcacg tttggggtgg cctagcagat ttatcagagg gcggtgacaa tgcggccgat     9660

gagtggagtg cgctagtgga ccgcattgcc gcaccccacg gttcagcagt tagggaggac     9720

caactggcgc tgagagacag ggccgtatat acgccaagac tggccagacg ttctgcgccc     9780

ccgagcggga ctcccctaca tctacgaggg gatggcacag tgttaataac aggtgggact     9840

ggtacactag gtaggctatt agcgcgtcac ctagtaacag agcatggggt gcggcatctc     9900

ttactagttt caaggagagg cgccgatgcc cctggctcgg atgaactgcg cgcagaaata     9960

gaggacttag gtgccagcgc ggagatcgca gcgtgtgata cagcggatcg cgatgcccta    10020

tctgccctac tagatggtct cccccggccc cttacgggtg tcgttcacgc cgctggcgtg    10080

ttagccgatg gacttgtcac tagcattgac gagcctgcgg tggaacaggt tctccgagca    10140

aaggtggacg cggcatggaa cctacacgaa ctcacagcta ataccgggct atcctttttc    10200

gttcttttct catcagcagc atcggtcctg gcaggtccag ggcaaggagt ttatgcggct    10260

gcaaatgaat cgctcaacgc actagctgcg ttaaggcgaa ctaggggtct gccggccaag    10320

gctctgggat ggggcctgtg ggccatcggg cgggcaatcg cttttgcgga gcagaccggg    10380

gacgccatcg ctccagagga aggagcatac gcttttgaaa ctctgttaag gcataaccgt    10440

gcctactcgg gatatgcgcc cgtcattgga tctccctggt tgaccgcgtt cgcacagcat    10500

tccccctttg cagaaaaatt ccaatcactc ggacagaatc ggtcagggac atcgaaattc    10560

ttagcggagc tagttgacct gcctcgtgag gaatggccgg ataggctcag gagactacta    10620

gagttagtta ggtcccatgc cgccgcggtc tccggttacg gtagtgcaga tcaactgccg    10680

gaaagaaaag cgttcaagga tttggggttt gattcgctgg ccgccgttga actgcgtaac    10740

cggctgggaa cggctacagg ggtacgactg ccgtcaaccc tagtatttga tcacccaact    10800

ccgctggccg tcgctgagca cttaagagat aggctaacat ccggggaaga taaccctatc    10860

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    10920

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    10980

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    11040

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    11100

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    11160

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    11220

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    11280

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    11340

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    11400

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    11460

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    11520

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    11580

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             11631


<210>  20
<211>  11970
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCS

<400>  20
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcgg agagccgttc ccactcgctc ctatgcaaca cgccatgtgg     3240

gtagggcggc acgaccacca acagctcggg ggagtagcag gccatcttta cgtcgagttt     3300

gacggcgcga gagtcgaccc cgatcggttg cgcgctgccg ccacccgact cgccctacgt     3360

caccctatgt tgagggtaca gttcctgcct gacggtacac aaaggatccc tccagccgca     3420

ggctcgcggg actttcccat cagcgttgcg gatcttcgtc acgtagctcc tgacgttgtc     3480

gatcaacggc tcgcgggtat tagagacgca aagtctcatc aacagcttga tggagctgtc     3540

ttcgagttgg ctctcactct cctgccaggt gaaaggacga ggctgcacgt cgacctggat     3600

atgcaagctg ctgacgccat gagctacagg atcctgctgg cggacttggc cgcactatac     3660

gacgggagag agcccccagc actcggttac acgtatagag agtaccgcca ggctattgag     3720

gccgaggaaa cattaccgca acctgttcgc gacgccgata gggactggtg ggcacaaaga     3780

ataccacagc ttccagaccc gcccgcacta ccgacgcgtg ccggtggtga gagagatcgc     3840

cggcgctcga ccagaagatg gcactggtta gacccacaaa caagggacgc cctcttcgca     3900

cgagcacgag ctcgtggcat cacacctgca atgacacttg cggccgcgtt tgcaaatgtc     3960

ctcgcgagat ggtccgcctc ttcccggttc ttactcaatt tgcccctttt ctcgcgccaa     4020

gcgttgcatc cggacgtaga cctcttggta ggtgacttca catcgtcgct gctgttagat     4080

gttgacctag gagatacagt gtctaatctt gctcggaaga accaactgac ttttacggag     4140

gactgggaac accggcattg gagcggagta gagttgctgc gagaactcaa aaggcaacag     4200

cgttacccac acggagcgcc cgtggtgttc acttctaatc ttgggcgcag tttatattct     4260

tctcgggcgg agtccccctt gggagagcct gaatggggaa tttcgcaaac accacaggtt     4320

tggatcgacc atttagcatt tgagcaccat ggggaagtat ggctccaatg ggactcgaac     4380

gacgccctct tcccacctgc tttagtcgag actctgtttg acgcgtactg tcaattgata     4440

aaccagctgt gcgacgatga atccgcatgg caaaagccct tcgcggacat gatgccggcg     4500

agtcagcgtg ctattcgtga gcgggtgaac gctaccggcg caccgatccc ggagggcctc     4560

ttacacgaag ggatttttcg gatcgctctt caacagcctc aggcgctcgc ggtaacggac     4620

atgcggtacc aatggaatag ttatcgagag atgcgggaac aggtcgtcgc tttggcaaat     4680

ctactccgag agcgcggggt caagccaggg gactcagtcg ctgtagcgct tcctcggtca     4740

gtcttcctaa ccttggctct ccacgcgatc gtagaggcgg gtgcggcgtg gcttcccctc     4800

gacacgggct atccggacga tcggttgaag atgatgctag aggatgcacg accctctctg     4860

ttaatcacaa ccgacgatca actccccagg ttctcagacg tccctaatct taccagtcta     4920

tgttacaacg cgcccctcac tccacaaggc agcgctcctt tacaacttag tcagccgcac     4980

cataccgctt atatcatttt tacgtccggt tccacgggca ggccgaaggg tgtaatggtg     5040

ggccaaactg caatagtgaa tagactattg tggatgcaaa accactaccc gcttaccggg     5100

gaggacgtag tggctcaaaa gactccctgc tctttcgatg tcagcgtgtg ggagttcttt     5160

tggcctttta tagccggcgc taaattggtt atggcggagc cggaagctca ccgagaccct     5220

ttggccatgc aacagttctt tgcagagtat ggagtcacaa cgacgcattt cgtcccatcg     5280

atgttagccg cgttcgtagc atcattgacg ccacaaactg cgagacagtc atgtgccaca     5340

cttaagcaag tcttctgctc tggtgaggcc cttcctgcgg acctatgtcg ggaatggcaa     5400

cagcttactg gagccccctt gcacaatctt tacgggccga ctgaggccgc agttgacgta     5460

tcgtggtatc cagcgttcgg ggaggagcta gcccaagtgc gagggtctag tgttccaatt     5520

ggatacccgg tgtggaacac agggttaagg atcctcgacg ccatgatgca tccggtacca     5580

ccaggtgtcg ctggggattt gtacctgact ggcattcaac tggcacaggg ttatctaggg     5640

cggcctgact taacagctag ccgattcata gcagatccat tcgctcccgg agagcggatg     5700

taccgaacag gcgacgtggc acgctggtta gataatggcg ctgtcgagta tcttgggcgg     5760

tcagacgatc agttaaagat acgtggacaa cggattgagc ttggtgaaat agaccgagtt     5820

atgcaggcac taccagatgt cgagcaagcc gtagcctctt gtgccattgc gcgagaagac     5880

attcccggga acaagcactt ggttgcgtac atagtgccgc aagaggagca gacctgcaca     5940

gagcggtcac gttcaactct cacagtttcc ttcgtccgtt ctttcttaaa ggagaaacta     6000

ccagaatata tggtaccgtc cgcgatcgtg atattagacg ctctgccact cacgccaaat     6060

ggaaagttgg atagaagagc tctgcctgct cctgacttgc actcgcaact cctggataaa     6120

tacgttgctc ccagaaaccc aatagagact attatcgcgg cagcattctc ttcattgctt     6180

ggatgcgacg tccaagatgc ggacgcagat ttctttgcgc tcgggggcca tagtctattg     6240

gccatgaagc tcgcagcgca attgtcgaga caggtagcac ggcaagtaac gcccgggcaa     6300

gtcatggtcg cctcgacagt cgcgaaactc gcgaccatta tcgacgctga gctgccagta     6360

gaacagcctt ttgtgcactc accggaagag cggtatcgac cattcgcgtt aacggatgtt     6420

cagcaagcct acctggtcgg gcgccagccg ggatttgccc tgggcggtgt aggctcgcat     6480

ttcttcgtgg aattcgagat cgcagatctc gacatacacc gcctggaaaa agtgtggaac     6540

cgtttaattg cacgtcatga tatgttgcgc gctgtggttc gtgacggtca gcaacgtgta     6600

ctggaacaga ccccgccatg ggtcatacca gcacatattc ttcacagtcc tgaagaggca     6660

ttacaggttc gtgatcgttt agctcaccaa gtgttgaacc ccgaagtctg gccggtattt     6720

gatctgcagg tgggcttcgt tgacggtatg ccggcccgtt tatggttgtg ccttgataac     6780

ctgttattgg acgggctgag catgcagatt cttctctctg aactggagca tggatatcgc     6840

tacccacagc aactccctcc cccgttgccg atcacttttc gcgattatct tcagcaaccg     6900

gcactccgta ccccaaatcc tgactcattg gcttggtggc agacgcaact ggatgacatc     6960

ccacctgcgc ccgccctccc gctacgttgt ctgcctcaag atgttgaaac cccgcgtttc     7020

gcgcgtctgt acggcgcaat ggattctgct cgttggcgtc gcctgaaaca gcgtgcggcc     7080

gacgcacatc tgactccgtc agctgtccta ctgagcgtat ggtctacagt gctggcagct     7140

tggtcggcgc agccggattt tactctcaac ctgacattat tcgaccggcg accactgcac     7200

cctcagatta atcaaatcct tggcgatttt acctcactga tgttattgtc gtggcatccg     7260

ggtgagagtt ggctgcagtc cgcgcgtctt ctccagcaac gcctttcaga atcgctcaac     7320

caccgtgatg ttagcgccat tcgcgtcatg cggcagctgg cgagaaggca aaatgtcccg     7380

gccgtaccca tgccggtcgt atttacctct gcgctggggt ttgaacagga taacttcctg     7440

gcccgtcgca atctactgaa accggtgtgg ggtatcagtc agacgccgca agtttggctg     7500

gaccatcagg tctatgaatc cgagggcgaa ctgcgtttta actgggattt cgttgcggcc     7560

ctgtttccgg acggtcaagt ggaacgtcag ttcgcgcaat actgcgcctt attgaatcgc     7620

atggcagaag atgacagctc ttggcagttg ccgcttgctg atctggtgcc cccgttaaaa     7680

gtgaccgagc ggcgagcgag aaggctgcgt ccagaacgcg cccagcctcg tattgcagct     7740

gataagagtt ccgttagtct gatctgtgac acttttcgtg aggtggttgg ggaacccgtg     7800

gcaccggctg agaacttttt cgaagcggga gccacatccc tcaatctggt tcagctgcat     7860

gtccttctcc aacgtcacga atttgcgacc ttaacgctac tggatttgtt cacccatcca     7920

agccctgttg cattggctaa ctatcttgcg ggtgtggccc tggaagagaa aacgaagcgc     7980

gtgcggccgg ttcggcgaag acagcgtcgc attcagcact tgcccttagt agctgcgcaa     8040

cctggaatat ggatggccga gaagttatct gaactaccat cagcgtggag cgtagcgcat     8100

tacgtggagc tcactggtga ggttgactcg cctcttttgg ccagggcggt agtggctggc     8160

cttgcacaag ctgacacctt aagaatgcgt ttcacagagg ataatgggga agtttggcaa     8220

tgggtagacg atgcgttaac atttgagtta ccggaaatca tagacctgcg cactaacata     8280

gaccctcacg ggacagctca ggccttgatg caagcggacc tgcaacagga cctacgtgtg     8340

gattcgggga agcctctggt cttccatcag ctaattcaag tagcggacaa tcgctggtac     8400

tggtatcaaa ggtaccacca cttgcttgtg gacgggttca gttttccagc gataaccagg     8460

caaatagcca acatttattg cacttggttg cgaggagagc ctacgcccgc atcccccttc     8520

acgccattcg cagacgttgt tgaggaatac caacagtatc gcgagagcga agcgtggcaa     8580

cgcgatgcgg cattctgggc ggagcaacga cggcaactac cgcctcccgc atccctatca     8640

cctgccccgc tccccggccg gtccgcgtca gccgacattc tacggctaaa gctggagttc     8700

acagatggtg aatttcgaca gcttgctaca caactcagcg gggtacaaag gacagaccta     8760

gcgctcgctc tggctgcatt atggctagga cgactttgca atcgaatgga ctacgcggcg     8820

ggtttcatat ttatgcgccg gctcggcagc gcagcgttga ccgcaacggg tccagtttta     8880

aatgttcttc ctttgggaat ccacataggc aacccaagct tctctgagct tctcaccagg     8940

gttcgcgagg tcgccttagg cgcgtatgca caccaacata ttccttttga gatgttagta     9000

gaggcactgc aaccagagcg aaaccttagc catactcctc tcttccaagt gatgtttgtc     9060

cttcagaatg cgcccgcgtc ccaattagag ttaaccggga tcaccgcaaa cccaattaag     9120

gttaaatcaa ctaccacgaa gttcgaccta actttaatca tgcaaaacac agctagcgga     9180

ttagtaggtg tttgggagta caacacggat ttattcgacg cgtcaacgat tgagcgaatg     9240

acagggcact ttgtaaccct cctcgagggc gttatcgcca atccacaaca gccgatctct     9300

caacttccta ttttaactac agtggagcaa cagcaacttt tagtcgagtg gaataacacg     9360

caaaccgact accccgctga taagtgtata catcaattat tcgaggaaca ggtcgagcgc     9420

acaccagacg ccgttgctgt cgtctttggg aatcagcaac tcagctatcg agagatgcgc     9480

gaacaagtgg ttgcactcgc caatttatta cgtgagcggg gagtcaagcc aggagactcc     9540

gttgccgtgg ccttaccacg ctctgttttc ttaacccttg cactacacgc gattgtcgag     9600

gcaggtgccg cctggctacc tcttgacaca ggatatcctg acgatagatt aaaaatgatg     9660

ctcgaggatg cacggccttc ccttctgatc acaacagacg atcaattacc ccgcttcagt     9720

gacgtaccta atctgacctc actctgttac aacgctccct tgacgcctca agggagcgcc     9780

cctttacagc tgtctcaacc tcaccatact gcatatatca tctttacaag tggttctacg     9840

ggacgcccca agggagtaat ggttggtcag actgcgattg taaatcgtct gttgtggatg     9900

caaaaccact accctttgac gggggaggac gttgtagccc aaaagactcc ttgctcgttc     9960

gatgtctcag tctgggagtt cttttggcca tttatagcag gggccaaatt agttatggcg    10020

gagccggaag cccaccgaga cccacttgcg atgcagcaat tctttgctga gtatggtgtc    10080

accactacac atttcgtccc atcgatgtta gcggccttcg tggcttctct tactccacaa    10140

acggctaggc aatcttgtgc cacactaaag caagtcttct gctccggcga ggcattacct    10200

gcagacttgt gccgggaatg gcagcaactc acaggagctc cattgcacaa tctatacgga    10260

ccgaccgagg ccgcagtaga cgtatcttgg tatcctgcgt ttggcgagga gttagcgcaa    10320

gtaagaggtt cgtcagtacc aataggatac cccgtatgga acacggggct tcggatactg    10380

gacgcgatga tgcatccggt cccaccagga gtcgcgggcg atttatacct gactgggata    10440

cagctggccc aaggttacct agggagacct gaccttacgg cgtcgaggtt catagcggat    10500

ccgtttgctc cgggtgagcg catgtaccgt acgggcgacg tcgcgcgatg gctagataat    10560

ggcgccgtag agtatcttgg tagatcagac gatcagttaa agatacgggg acaacgaata    10620

gagcttgggg aaatagaccg ggtaatgcag gctttgccag atgtcgagca agcggtggct    10680

tcgtgtgcta ttgcgcggga ggacatacct gggaacaaac accttgtagc gtacatagtt    10740

cctcaagagg agcaaacatg cactgagcga tcgaggtcca cacttacagt ttcgttcgtc    10800

cggagtttcc ttaaggagaa actccccgaa tatatggtac cgagcgcaat agtgattcta    10860

gacgctctcc ccctgactcc taatggaaag ctagaccggc gggcgttacc cgcccctgac    10920

ctgcactcac aacttgagac aattattgct gcggctttct cgagcctgct cgggtgcgac    10980

gtacaagacg cggatgctga ctttttcgcg ctaggtggcc attcgctgct tgccatgaag    11040

ctagccgctc agctttcccg acaagtagcg cggcaggtga caccaggcca agttatggta    11100

gcttcgactg tcgcaaagct cgcaacgatc atagacgcgg agttagataa atacgtcgct    11160

ccaaggaacc cgataacatc cggggaagat aaccctatcc ccctatgtca aggcgatggg    11220

gaggagatga gcacatggct acgtcgtttt ggacccccag tcgaacatcg ggccaggcta    11280

gtgtgtttcc cccacgcagg cgcagcggcg gattcatact tagacctagc aagagcgtta    11340

gcaccagaga tcgatgttca tgctgttcaa taccccggca ggcaagacag aagggacgag    11400

gagccattag gaaccgcagg tgaaattgca gatgaagtgg cagcggtgct acgtgcgtcg    11460

ggaggggatg ggccttttgc acttttcggc cacagtatgg gcgccctcat cgcgtacgag    11520

acagcaaggc gattagagag ggaaccggga gggggaccct tacgtttatt cgtgagcgga    11580

caaacagcgc cacgtgtcca tgaacgaaga actgatctgc ccggtgacga tggactcgtg    11640

gacgagctta ggcgacttgg cacctccgag gcagcgctcg cagacgaagc cctgctggct    11700

atgtctctcc cggtgctcag ggcggattat agggtgttaa gatcctacgc ttgggcggat    11760

ggtcccccac tacgcgccgg tataactgcc ctctgcggtg atgcagaccc actaactgca    11820

acaggggatg cggaacgctg gttacaacat tccgtgattc cgggtcggac acggacattt    11880

cccggtgggc atttttattt aggggaacaa gtgaccgagg tggcaggggc tgtccgtaga    11940

gatttactga gagcagggtt agcgggttga                                     11970


<210>  21
<211>  13269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHC

<400>  21
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac tgccagtaga acagcctttt     7680

gtgcactcac cggaagagcg gtatcgacca ttcgcgttaa cggatgttca gcaagcctac     7740

ctggtcgggc gccagccggg atttgccctg ggcggtgtag gctcgcattt cttcgtggaa     7800

ttcgagatcg cagatctcga catacaccgc ctggaaaaag tgtggaaccg tttaattgca     7860

cgtcatgata tgttgcgcgc tgtggttcgt gacggtcagc aacgtgtact ggaacagacc     7920

ccgccatggg tcataccagc acatattctt cacagtcctg aagaggcatt acaggttcgt     7980

gatcgtttag ctcaccaagt gttgaacccc gaagtctggc cggtatttga tctgcaggtg     8040

ggcttcgttg acggtatgcc ggcccgttta tggttgtgcc ttgataacct gttattggac     8100

gggctgagca tgcagattct tctctctgaa ctggagcatg gatatcgcta cccacagcaa     8160

ctccctcccc cgttgccgat cacttttcgc gattatcttc agcaaccggc actccgtacc     8220

ccaaatcctg actcattggc ttggtggcag acgcaactgg atgacatccc acctgcgccc     8280

gccctcccgc tacgttgtct gcctcaagat gttgaaaccc cgcgtttcgc gcgtctgtac     8340

ggcgcaatgg attctgctcg ttggcgtcgc ctgaaacagc gtgcggccga cgcacatctg     8400

actccgtcag ctgtcctact gagcgtatgg tctacagtgc tggcagcttg gtcggcgcag     8460

ccggatttta ctctcaacct gacattattc gaccggcgac cactgcaccc tcagattaat     8520

caaatccttg gcgattttac ctcactgatg ttattgtcgt ggcatccggg tgagagttgg     8580

ctgcagtccg cgcgtcttct ccagcaacgc ctttcagaat cgctcaacca ccgtgatgtt     8640

agcgccattc gcgtcatgcg gcagctggcg agaaggcaaa atgtcccggc cgtacccatg     8700

ccggtcgtat ttacctctgc gctggggttt gaacaggata acttcctggc ccgtcgcaat     8760

ctactgaaac cggtgtgggg tatcagtcag acgccgcaag tttggctgga ccatcaggtc     8820

tatgaatccg agggcgaact gcgttttaac tgggatttcg ttgcggccct gtttccggac     8880

ggtcaagtgg aacgtcagtt cgcgcaatac tgcgccttat tgaatcgcat ggcagaagat     8940

gacagctctt ggcagttgcc gcttgctgat ctggtgcccc cgttaaaagt gaccgagcgg     9000

cgagcgagaa ggctgcgtcc agaacgcgcc cagcctcgta ttgcagctga taagagttcc     9060

gttagtctga tctgtgacac ttttcgtgag gtggttgggg aacccgtggc accggctgag     9120

aactttttcg aagcgggagc cacatccctc aatctggttc agctgcatgt ccttctccaa     9180

cgtcacgaat ttgcgacctt aacgctactg gatttgttca cccatccaag ccctgttgca     9240

ttggctaact atcttgcggg tgtggccctg gaagagaaaa cgaagcgcgt gcggccggtt     9300

cggcgaagac agcgtcgcat tggagagccg ttcccactcg ctcctatgca acacgccatg     9360

tgggtagggc ggcacgacca ccaacagctc gggggagtag caggccatct ttacgtcgag     9420

tttgacggcg cgagagtcga ccccgatcgg ttgcgcgctg ccgccacccg actcgcccta     9480

cgtcacccta tgttgagggt acagttcctg cctgacggta cacaaaggat ccctccagcc     9540

gcaggctcgc gggactttcc catcagcgtt gcggatcttc gtcacgtagc tcctgacgtt     9600

gtcgatcaac ggctcgcggg tattagagac gcaaagtctc atcaacagct tgatggagct     9660

gtcttcgagt tggctctcac tctcctgcca ggtgaaagga cgaggctgca cgtcgacctg     9720

gatatgcaag ctgctgacgc catgagctac aggatcctgc tggcggactt ggccgcacta     9780

tacgacggga gagagccccc agcactcggt tacacgtata gagagtaccg ccaggctatt     9840

gaggccgagg aaacattacc gcaacctgtt cgcgacgccg atagggactg gtgggcacaa     9900

agaataccac agcttccaga cccgcccgca ctaccgacgc gtgccggtgg tgagagagat     9960

cgccggcgct cgaccagaag atggcactgg ttagacccac aaacaaggga cgccctcttc    10020

gcacgagcac gagctcgtgg catcacacct gcaatgacac ttgcggccgc gtttgcaaat    10080

gtcctcgcga gatggtccgc ctcttcccgg ttcttactca atttgcccct tttctcgcgc    10140

caagcgttgc atccggacgt agacctcttg gtaggtgact tcacatcgtc gctgctgtta    10200

gatgttgacc taggagatac agtgtctaat cttgctcgga agaaccaact gacttttacg    10260

gaggactggg aacaccggca ttggagcgga gtagagttgc tgcgagaact caaaaggcaa    10320

cagcgttacc cacacggagc gcccgtggtg ttcacttcta atcttgggcg cagtttatat    10380

tcttctcggg cggagtcccc cttgggagag cctgaatggg gaatttcgca aacaccacag    10440

gtttggatcg accatttagc atttgagcac catggggaag tatggctcca atgggactcg    10500

aacgacgccc tcttcccacc tgctttagtc gagactctgt ttgacgcgta ctgtcaattg    10560

ataaaccagc tgtgcgacga tgaatccgca tggcaaaagc ccttcgcgga catgatgccg    10620

gcgagtcagc gtgctattcg tgagcgggtg aacgctaccg gcgcaccgat cccggagggc    10680

ctcttacacg aagggatttt tcggatcgct cttcaacagc ctcaggcgct cgcggtaacg    10740

gacatgcggt accaatggaa tagttatcga gagatgcggg aacaggtcgt cgctttggca    10800

aatctactcc gagagcgcgg ggtcaagcca ggggactcag tcgctgtagc gcttcctcgg    10860

tcagtcttcc taaccttggc tctccacgcg atcgtagagg cgggtgcggc gtggcttccc    10920

ctcgacacgg gctatccgga cgatcggttg aagatgatgc tagaggatgc acgaccctct    10980

ctgttaatca caaccgacga tcaactcccc aggttctcag acgtccctaa tcttaccagt    11040

ctatgttaca acgcgcccct cactccacaa ggcagcgctc ctttacaact tagtcagccg    11100

caccataccg cttatatcat ttttacgtcc ggttccacgg gcaggccgaa gggtgtaatg    11160

gtgggccaaa ctgcaatagt gaatagacta ttgtggatgc aaaaccacta cccgcttacc    11220

ggggaggacg tagtggctca aaagactccc tgctctttcg atgtcagcgt gtgggagttc    11280

ttttggcctt ttatagccgg cgctaaattg gttatggcgg agccggaagc tcaccgagac    11340

cctttggcca tgcaacagtt ctttgcagag tatggagtca caacgacgca tttcgtccca    11400

tcgatgttag ccgcgttcgt agcatcattg acgccacaaa ctgcgagaca gtcatgtgcc    11460

acacttaagc aagtcttctg ctctggtgag gcccttcctg cggacctatg tcgggaatgg    11520

caacagctta ctggagcccc cttgcacaat ctttacgggc cgactgaggc cgcagttgac    11580

gtatcgtggt atccagcgtt cggggaggag ctagcccaag tgcgagggtc tagtgttcca    11640

attggatacc cggtgtggaa cacagggtta aggatcctcg acgccatgat gcatccggta    11700

ccaccaggtg tcgctgggga tttgtacctg actggcattc aactggcaca gggttatcta    11760

gggcggcctg acttaacagc tagccgattc atagcagatc cattcgctcc cggagagcgg    11820

atgtaccgaa caggcgacgt ggcacgctgg ttagataatg gcgctgtcga gtatcttggg    11880

cggtcagacg atcagttaaa gatacgtgga caacggattg agcttggtga aatagaccga    11940

gttatgcagg cactaccaga tgtcgagcaa gccgtagcct cttgtgccat tgcgcgagaa    12000

gacattcccg ggaacaagca cttggttgcg tacatagtgc cgcaagagga gcagacctgc    12060

acagagcggt cacgttcaac tctcacagtt tccttcgtcc gttctttctt aaaggagaaa    12120

ctaccagaat atatggtacc gtccgcgatc gtgatattag acgctctgcc actcacgcca    12180

aatggaaagt tggatagaag agctctgcct gctcctgact tgcactcgca actcctggat    12240

aaatacgttg ctcccagaaa cccaatagag actattatcg cggcagcatt ctcttcattg    12300

cttggatgcg acgtccaaga tgcggacgca gatttctttg cgctcggggg ccatagtcta    12360

ttggccatga agctcgcagc gcaattgtcg agacaggtag cacggcaagt aacgcccggg    12420

caagtcatgg tcgcctcgac agtcgcgaaa ctcgcgacca ttatcgacgc tgagacatcc    12480

ggggaagata accctatccc cctatgtcaa ggcgatgggg aggagatgag cacatggcta    12540

cgtcgttttg gacccccagt cgaacatcgg gccaggctag tgtgtttccc ccacgcaggc    12600

gcagcggcgg attcatactt agacctagca agagcgttag caccagagat cgatgttcat    12660

gctgttcaat accccggcag gcaagacaga agggacgagg agccattagg aaccgcaggt    12720

gaaattgcag atgaagtggc agcggtgcta cgtgcgtcgg gaggggatgg gccttttgca    12780

cttttcggcc acagtatggg cgccctcatc gcgtacgaga cagcaaggcg attagagagg    12840

gaaccgggag ggggaccctt acgtttattc gtgagcggac aaacagcgcc acgtgtccat    12900

gaacgaagaa ctgatctgcc cggtgacgat ggactcgtgg acgagcttag gcgacttggc    12960

acctccgagg cagcgctcgc agacgaagcc ctgctggcta tgtctctccc ggtgctcagg    13020

gcggattata gggtgttaag atcctacgct tgggcggatg gtcccccact acgcgccggt    13080

ataactgccc tctgcggtga tgcagaccca ctaactgcaa caggggatgc ggaacgctgg    13140

ttacaacatt ccgtgattcc gggtcggaca cggacatttc ccggtgggca tttttattta    13200

ggggaacaag tgaccgaggt ggcaggggct gtccgtagag atttactgag agcagggtta    13260

gcgggttga                                                            13269


<210>  22
<211>  14592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHH

<400>  22
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac ctggaattgg ggcgctagtt     7680

cccgctcccg tggtaatcgc agcaggccgt acggaggaac caattgccat agtatccatg     7740

gcttgccggt tacccggtgg tgtgaatacc ccacagagac tatgggaatt attacgtgaa     7800

gggggagaaa ccctcagtgg cttccctacc gaccgagggt gggacctcgc gaggttgcat     7860

cacccagacc cagacaaccc cggtacgtca tacgttgata aagggggatt cctggacgat     7920

gcggcagggt ttgacgcaga atttttcggt gtgagcccca gagaagcagc ggctatggac     7980

ccgcagcaga gattactcct cgaaaccagc tgggagttag tcgagaatgc agggattgat     8040

ccacatagcc taagggggac cgccactggt gtcttcctcg gcgttgccaa gtttgggtat     8100

ggcgaggata cggcagctgc cgaagacgtc gaggggtact ctgtcactgg tgtagccccg     8160

gcagtggcgt cgggcagaat tagttacacg atggggttgg aagggccgtc tatttcggtt     8220

gataccgcct gttcctccag tctggttgca ctccaccttg cagtcgagtc gctccggaaa     8280

ggagaaagca gtatggccgt ggtcggggga gcggcggtga tggccacacc gggtgtgttt     8340

gtggattttt cccgacagag agccttggcc gcggatgggc gttcaaaggc gttcggagca     8400

ggtgcagacg ggtttggatt tagcgaaggt gtgacactgg ttctcctaga aagattaagt     8460

gaagcccggc gtaacggcca tgaggtgctg gcagttgtta gaggttccgc attaaaccag     8520

gacggggctt cgaacgggct gagcgccccc tcgggcccgg cacagagaag agtgatacgc     8580

caagcactcg aatcgtgtgg cctagaacca ggtgacgttg acgcggtgga agcgcacggg     8640

acaggaactg cgttagggga cccgatagaa gcaaacgcct tgctggacac ttatggtaga     8700

gatcgtgatg cggatcgacc cctctggtta ggaagtgtta agtcaaatat aggacacact     8760

caggcagcgg cgggagtaac tgggctgctc aaagtagtcc tagccttacg caatggggaa     8820

ctacccgcca ccctacatgt cgaggaaccg acaccgcatg tggattggtc gagcggggga     8880

gttgctctct tggcgggtaa tcagccgtgg cgaagaggtg aacgaacccg tagagccgcc     8940

gtgtccgcat tcgggatcag tggtacgaac gcgcacgtga ttgtggaaga agctccacaa     9000

gaggtgagac cagcgcccgg tcaaggactc tcgcccgcgg tgtcaacctt ggtagtggcg     9060

ggtaaaacta tgcagcgtgt ttcggcaacc gccggtatgc tcgcagattg gatggaaggc     9120

ccaggtgcag atgtggcgct ggcggacgtg gcgcacacgt taaatcatca ccgttcacgg     9180

caaccaaagt tcggtacggt ggtggccagg gaccggacac aggcaatcgc cggactaaga     9240

gcgctggcgg cgggtcagca cgccccaggg gttgttaacc ctgctgaagg aagtccaggt     9300

ccagggacgg tgttcgtgtt tcctggccag gggtcccagc gtgcaggcat gggggaggag     9360

ttggctgcgg ctttccccgt gtttgccaga atccaccagc aagtgtggga tttactcgat     9420

gttcctgatc tcgacgttaa cgaaacgggg tacgcacaac cagcactctt cgcactccaa     9480

gtggcgctgt ttgggctcct cgaatcatgg ggagtacggc cggatgccgt ggtcgggcat     9540

agtgtagggg aattagcggc agggtacgtt tccgggcttt ggagtcttga ggatgcttgc     9600

acgctcgtgt cggcgagagc ccgtctaatg caagccttac cggcaggtgg tgttatggcg     9660

gcagttccag tgtccgaaga cgaagcacgg gctgtgttgg gggaaggagt cgaaatagct     9720

gcggtcaacg gtccgtcgag cgtggttcta agcggtgatg aagcagcagt gctccaggcc     9780

gcggaagggt taggcaagtg gacgcgatta ccgacctcgc atgcattcca ttctgctcgt     9840

atggaaccaa tgctggaaga gtttagagca gtggcggaag gtctaacata caggactccc     9900

caggtggcaa tggccgccgg agaccaggtt atgaccgctg aatactgggt gcgtcaggtt     9960

agggatacag ttcgttttgg cgagcaagtt gcctcgttcg aggatgctgt attcgtggaa    10020

ttgggagcag atcgctctct tgcacggcta gtcgatggta tcgcgatgtt gcacggggat    10080

catgaggcac aggctggtat gcggagagaa caacccttgc ccttaggttt acgaagattg    10140

ctaaccgacc tgcataacgc tggtgctgcc gtcgatttta gtgttttgtg cccacaaggt    10200

cgtctggttg acgcaccgtt accagcctgg tcacaccggt ttctcttcta tgaccgggaa    10260

ggagtggaca atagatcacc agggggaagc acagtggcgg tccacccgct tttactagcc    10320

gcggtggatg tgccgggcca cggtggagcg gttttcacgg gtagactctc gactgacgag    10380

caaccgtggt tagcggagca cgttgtcggg ggaagaaccc tagttcctgg ttctgtttta    10440

gtcgatctag ccttagcggc aggcgaagac gtagggctac cggtgttaga agaattagta    10500

ttgcagaggc cgctggtgct tgccggcgcg ggagcactcc tacggatgtc ggtcggggca    10560

ccagacgaga gcggtagaag aactatcgat gttcacgcag ctgaagacgt cgccgattta    10620

gcagatgccc aatggtccca gcacgccacc gggactttag cccaaggggt agcggcgggg    10680

cccagggaca cagagcaatg gcccccagag gatgccgtcc ggattccatt agacgaccat    10740

tatgatggtc tcgcggaaca gggttatgag tacggtccgt cgtttcaggc gctagtggcc    10800

tacgtggcgg aggatgcgac tgcgacaatg ttagcggaag tcgcgcttcc gggcagcatt    10860

agatcgcaac aaggtctata cgccatccat cccgcactgc tggacgcttg ttttcaatct    10920

gtcggagccc acccagacag tcaatccgtc gggtcaggtc tactcgtacc cctcggtgtt    10980

cggagagttc gtgcgtacgc acccgtaagg accgcccgtt attgttacac ccgcgtcacg    11040

aaagttgaac tagctggggt tgaggccgac atcgacgttc tggatgctca cggcacagtg    11100

cttctagccg tgtgcggtct tcgtatcggg accggagtga gcgagaggga caaacacaac    11160

agagttctca atgagcgcct actcaccatc gaatggcatc agcgtgaact accagaaatg    11220

gacccctcgg gtgccgggaa gtggctccta atctcggact gtgcagcatc cgatgtcacc    11280

gctacacgac tggctgatgc cttccgggag cacagcgctg cgtgcactac catgcggtgg    11340

ccacttcacg atgatcaact agcagccgcc gaccaactcc gggaccaggt gggttcagat    11400

gagttttctg gcgtggtagt actaacaggg ccaaacacag ggacccctca tcagggttcc    11460

gcagaccgtg gcgccgagta cgttaggcgg ttagttggaa tcgctcgtga acttagcgat    11520

cttcccggag cggttccccg tatgtatgtc gtcacaaggg gagcgcagag agtccttgcc    11580

gatgattgtg ttaatttaga acagggaggg ctcagaggtc tgctgaggac catcggtgct    11640

gagcacccac atctccgcgc cacccaaatt gatgttgatg agcagacagg agtagagcag    11700

ctggcgcgac aactcctagc tacatcggag gaagacgaga cagcctggag ggacaacgaa    11760

tggtacgttg cgaggttatg ccccacaccc ctgaggccac aggaacgtag gacaatagtg    11820

gcggaccatc aacagtctgg tatgcggtta caaatacgta cgcccggtgc aatcgatagt    11880

gtggcctttg aacccgcacc cgatgtagag caacccttac gggcgggtga agttcgggtt    11940

gacgttagag caaccggtgt taatttccgt gacgttctac tcgctctcgg gatgtatccc    12000

cagaaagctg acatggggac agaagcagct ggtgttgtaa cagcagtggg acctgatgtc    12060

gatgcgtttg cgcctggtga tagagttcta gggctattcc aaggggcatt tgctccaatt    12120

gcggtgactg accatcgttt actggcacgg gtgccagacg ggtggtcaga tgccgatgcg    12180

gcggcggtgc caatagctta cacgacagca cattatgcgc tgcacgacct ggcggggttg    12240

cgggcggggc aatctgtcct gatacacgcg gcagcgggtg gtgttggtat ggccgctgtt    12300

gcactggcac ggagggccgg cgcagaagtt ctggctaccg caggacctgc aaaacacggt    12360

acgctacggg cattagggct agatgatgaa cacatcgctt cgagtcggga gaccgggttc    12420

gcgcgtaagt tccgagagcg gactggggga cgaggagtgg acgtcgttct aaacagcttg    12480

accggcgaac tattagacga gtccgcggat ctcctcgcgg aggacggagt cttcgtggaa    12540

atgggaaaga ctgatctgcg cgatgcaggg gactttcgtg ggcgctacgc cccgtttgat    12600

ctaggggaag caggcgatga caggctcggg gaaattctac gtgaggtggt gggactgctc    12660

ggtgcagggg aactcgaccg actccctgtt agcgcgtggg aattggggat accccagacg    12720

gggaagtcgt tagtgacgct gccacccgaa caagcgcaag ttttcagacc agacggcact    12780

gtattgatca ccgggggaac gggaacgtta ggtcggctgc tggcccgtca tctggttaca    12840

gagcacgggg tgcgtcacct gctgctagtg tcgaggagag gagcagatgc ccctggatcg    12900

gacgagctga gggccgaaat cgaggatctc ggagcatcag cggaaattgc agcatgtgat    12960

acagccgatc gagacgctct cagcgcgttg ctagatggac tgccgaggcc actgaccgga    13020

gtagttcacg ccgcgggagt cctcgctgac ggtctggtta catccatcga cgagcccgca    13080

gtcgaacaag ttctccgtgc aaaagttgat gcggcctgga acctgcacga gctaactgcg    13140

aacaccggtc tcagcttttt cgtgctgttc tcgtcagccg caagtgtgtt agcggggccg    13200

gggcagggag tatatgcggc agcgaacgaa tctttaaacg ctctggccgc tctgcgtagg    13260

actaggggtt tacccgcaaa agcattggga tggggattat gggcgatagg gcgtgcaata    13320

gcatttgccg agcagaccgg tgacgcaatc gccccggagg aaggcgcgta cgccttcgag    13380

acactactca gacataacag ggcgtactcg ggttacgctc ccgtgatagg gtcaccatgg    13440

ctgactgcgt tcgcccaaca ttcgcccttt gcggagaagt tccagtccct ggggcaaaat    13500

agatccggga cgtctaagtt tctggcagaa ttagtcgatc tgccaagaga agaatggcca    13560

gatcggttac gtcgtctatt agaactggtg aggtctcatg ctgccgcagt ttcggggtat    13620

ggatcggcag accaattacc agaaagaaaa gcattcaaag acctcggatt cgattcactg    13680

gcagcagtcg aactaagaaa tcgtctaggg accgcgacag gcgtccggct gcccagtact    13740

ctggtgttcg accacccaac cccacttgcg gttgcggaac atctacgtga tcgtctaaca    13800

tccggggaag ataaccctat ccccctatgt caaggcgatg gggaggagat gagcacatgg    13860

ctacgtcgtt ttggaccccc agtcgaacat cgggccaggc tagtgtgttt cccccacgca    13920

ggcgcagcgg cggattcata cttagaccta gcaagagcgt tagcaccaga gatcgatgtt    13980

catgctgttc aataccccgg caggcaagac agaagggacg aggagccatt aggaaccgca    14040

ggtgaaattg cagatgaagt ggcagcggtg ctacgtgcgt cgggagggga tgggcctttt    14100

gcacttttcg gccacagtat gggcgccctc atcgcgtacg agacagcaag gcgattagag    14160

agggaaccgg gagggggacc cttacgttta ttcgtgagcg gacaaacagc gccacgtgtc    14220

catgaacgaa gaactgatct gcccggtgac gatggactcg tggacgagct taggcgactt    14280

ggcacctccg aggcagcgct cgcagacgaa gccctgctgg ctatgtctct cccggtgctc    14340

agggcggatt atagggtgtt aagatcctac gcttgggcgg atggtccccc actacgcgcc    14400

ggtataactg ccctctgcgg tgatgcagac ccactaactg caacagggga tgcggaacgc    14460

tggttacaac attccgtgat tccgggtcgg acacggacat ttcccggtgg gcatttttat    14520

ttaggggaac aagtgaccga ggtggcaggg gctgtccgta gagatttact gagagcaggg    14580

ttagcgggtt ga                                                        14592


<210>  23
<211>  12939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHO

<400>  23
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac ctggaattgg ggcgctagtt     7680

cccgctcccg tggtaatcgc agcaggccgt acggaggaac caattgccat cgtttcgatg     7740

gcatgtcgtt taccgggagg agtcaatacg ccccaacggc tctgggaatt actacgggag     7800

ggtggtgaaa ccttgtccgg gttcccaacg gaccgtggct gggacctagc acggcttcac     7860

caccctgatc cggacaaccc cggaacgagc tacgttgata agggtggatt tctcgacgac     7920

gcggcgggtt tcgacgcaga gtttttcggg gtttcaccaa gggaagctgc cgctatggac     7980

cctcagcaac gattactttt agagacctcg tgggagctag ttgaaaatgc gggcatagat     8040

ccacatagcc tgcgagggac agcgacaggg gtgttcctag gagttgcgaa gtttggttat     8100

ggtgaggaca cagcagcagc ggaagatgtt gaaggttatt cagttaccgg tgttgctccc     8160

gctgtggcat ctggccgcat atcctacact atgggtttag aaggtccttc catctcggtc     8220

gataccgcat gctcaagctc gctagtcgcg cttcatctag ccgtagagtc cctccgaaag     8280

ggtgagtcat ctatggcggt ggtgggtggt gcagccgtta tggcgactcc tggggtattt     8340

gttgattttt cacgccaacg ggcgcttgcc gcagacggcc gttccaaagc gttcggggca     8400

ggtgcagatg gttttggttt cagcgaggga gtcacgctgg ttctactaga gcgtttaagt     8460

gaggcgcgtc gtaacggtca tgaagttcta gctgtagtgc gcgggtccgc gttaaaccag     8520

gacggagcga gcaacggact ttcagcaccc tccggccctg cgcaacgtag agtaataagg     8580

caagcgctcg aatcgtgtgg gcttgaaccg ggggatgttg acgcggttga ggcgcatggt     8640

actggtacag cactaggtga cccaatagag gccaatgcgc tgttggacac ttacgggcga     8700

gaccgtgatg cggatcgtcc actttggttg gggtccgtta agagcaatat tgggcacact     8760

caagctgcgg ccggggttac aggactgctg aaggttgtgt tagcactgcg caatggtgag     8820

ctacctgcaa cgttacatgt cgaggaacca actccacacg tcgattggtc ctcaggtggt     8880

gtcgcattac tggcgggtaa tcaaccatgg cgaaggggag aaaggaccag aagggcggca     8940

gtgagcgcct ttggtatctc cggtacaaat gctcacgtga tagtggaaga ggcgcctcag     9000

gaagttcgac ccgcccctgg ccaagggctg tcgccagccg tgtccacgtt agttgttgca     9060

ggtaaaacca tgcagcgtgt aagtgcgaca gctggaatgc ttgcagactg gatggagggt     9120

cctggggccg atgttgcatt ggcggatgtg gcccataccc tgaaccatca ccgatcaaga     9180

cagcccaagt tcgggacggt tgtagcgcgt gacaggactc aggcgatagc tgggctccgt     9240

gcattggcgg ctggtcaaca tgctcctggg gtcgtcaacc cagctgaagg ttccccagga     9300

ccaggcaccg tgttcgtttt tcccggtcaa ggttcgcaga gggcagggat gggggaggaa     9360

ctcgcggcag cctttcctgt cttcgctcga atacatcagc aagtttggga cctcctagat     9420

gttcccgacc tcgacgttaa tgaaaccggg tacgcccaac cagcgctgtt cgcgcttcag     9480

gtcgcgctct ttggccttct ggagtcgtgg ggtgttaggc cagatgcagt ggtagggcac     9540

tcagttggtg agctggccgc ggggtacgtg tccggtcttt ggtcactaga ggacgcctgc     9600

acactagtct cagcaagagc gcgcctaatg caggcactgc ctgctggagg ggtgatggcg     9660

gcagtccccg tctccgagga tgaggcgcgg gccgtcctgg gcgagggagt tgaaattgcg     9720

gctgtgaatg gaccctcgtc cgttgtgctc tcaggggacg aggcggcagt cttacaggcc     9780

gccgaaggtc taggtaagtg gacgcgactg ccgaccagcc atgcttttca ctcagcgaga     9840

atggaaccca tgctagaaga gtttcgggcc gtagcagagg gtctgaccta tcgtacccct     9900

caagtagcta tggctgctgg ggatcaggtg atgacagcag aatattgggt gcggcaggtt     9960

cgggacacag ttcgcttcgg ggagcaagta gcgtcattcg aggatgcggt gtttgttgag    10020

ttaggcgctg acagaagtct agcgcgtttg gtggacggca tcgccatgct gcacggtgac    10080

cacgaagcgc aggccgcgga ccataggcaa atcaccgaag cggttgcgga tgcttacgtc    10140

ttaggccacc ttccggattt tgcggcgctg cggcggcctc acgcacgaaa gttggactta    10200

ccaacttatc ccttcgagcg tagacagtac tggttcagag atgcgcgtga gaggccggaa    10260

caacccagag ataccggcgg acctcgcaca gaagcagtcc gtctgttaga ggatggtagg    10320

attgaagaat tagctgcact tttgggaggg gccagtgatg accaacacac attacaggtg    10380

ctgactaagt tggcggcgca acataaccaa caacgaacaa cccggtcaat cgctgacgac    10440

aggtacgaaa taaggtggga ccgatcgact tccccactat ccggagcaga tgttgaccaa    10500

gcggggagct ggatcgtggt gtcagatgac gcagatgccg ttcccccgct agtggacttg    10560

ctggctgcac gtaacgagcc ccatcaggtt gttggtctac ccgcttcgga cgcagacgag    10620

gagaggctcg cagagactct gcgtgcggct gcgactgaag atgctaccct tcggatagtc    10680

cacgttgcgg cgctcgaagc aggcgctacc cccagcatgc gttcactgct ccgcatgcag    10740

caccgaatac taggtggcac gcggcgggtg ttcagggcag cggtcgcagc ggagttaaga    10800

ggtcccattt ggatagtgac gcggggagca caaagagtgg ctgacaccga tacagttgcc    10860

ccgcatcagt catgcctctg gggatttggg agggcagcat cgctggagct gccgcacgtt    10920

tggggtggcc tagcagattt atcagagggc ggtgacaatg cggccgatga gtggagtgcg    10980

ctagtggacc gcattgccgc accccacggt tcagcagtta gggaggacca actggcgctg    11040

agagacaggg ccgtatatac gccaagactg gccagacgtt ctgcgccccc gagcgggact    11100

cccctacatc tacgagggga tggcacagtg ttaataacag gtgggactgg tacactaggt    11160

aggctattag cgcgtcacct agtaacagag catggggtgc ggcatctctt actagtttca    11220

aggagaggcg ccgatgcccc tggctcggat gaactgcgcg cagaaataga ggacttaggt    11280

gccagcgcgg agatcgcagc gtgtgataca gcggatcgcg atgccctatc tgccctacta    11340

gatggtctcc cccggcccct tacgggtgtc gttcacgccg ctggcgtgtt agccgatgga    11400

cttgtcacta gcattgacga gcctgcggtg gaacaggttc tccgagcaaa ggtggacgcg    11460

gcatggaacc tacacgaact cacagctaat accgggctat cctttttcgt tcttttctca    11520

tcagcagcat cggtcctggc aggtccaggg caaggagttt atgcggctgc aaatgaatcg    11580

ctcaacgcac tagctgcgtt aaggcgaact aggggtctgc cggccaaggc tctgggatgg    11640

ggcctgtggg ccatcgggcg ggcaatcgct tttgcggagc agaccgggga cgccatcgct    11700

ccagaggaag gagcatacgc ttttgaaact ctgttaaggc ataaccgtgc ctactcggga    11760

tatgcgcccg tcattggatc tccctggttg accgcgttcg cacagcattc cccctttgca    11820

gaaaaattcc aatcactcgg acagaatcgg tcagggacat cgaaattctt agcggagcta    11880

gttgacctgc ctcgtgagga atggccggat aggctcagga gactactaga gttagttagg    11940

tcccatgccg ccgcggtctc cggttacggt agtgcagatc aactgccgga aagaaaagcg    12000

ttcaaggatt tggggtttga ttcgctggcc gccgttgaac tgcgtaaccg gctgggaacg    12060

gctacagggg tacgactgcc gtcaacccta gtatttgatc acccaactcc gctggccgtc    12120

gctgagcact taagagatag gctaacatcc ggggaagata accctatccc cctatgtcaa    12180

ggcgatgggg aggagatgag cacatggcta cgtcgttttg gacccccagt cgaacatcgg    12240

gccaggctag tgtgtttccc ccacgcaggc gcagcggcgg attcatactt agacctagca    12300

agagcgttag caccagagat cgatgttcat gctgttcaat accccggcag gcaagacaga    12360

agggacgagg agccattagg aaccgcaggt gaaattgcag atgaagtggc agcggtgcta    12420

cgtgcgtcgg gaggggatgg gccttttgca cttttcggcc acagtatggg cgccctcatc    12480

gcgtacgaga cagcaaggcg attagagagg gaaccgggag ggggaccctt acgtttattc    12540

gtgagcggac aaacagcgcc acgtgtccat gaacgaagaa ctgatctgcc cggtgacgat    12600

ggactcgtgg acgagcttag gcgacttggc acctccgagg cagcgctcgc agacgaagcc    12660

ctgctggcta tgtctctccc ggtgctcagg gcggattata gggtgttaag atcctacgct    12720

tgggcggatg gtcccccact acgcgccggt ataactgccc tctgcggtga tgcagaccca    12780

ctaactgcaa caggggatgc ggaacgctgg ttacaacatt ccgtgattcc gggtcggaca    12840

cggacatttc ccggtgggca tttttattta ggggaacaag tgaccgaggt ggcaggggct    12900

gtccgtagag atttactgag agcagggtta gcgggttga                           12939


<210>  24
<211>  13278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHS

<400>  24
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac tgccagtaga acagcctttt     7680

gtgcactcac cggaagagcg gtatcgacca ttcgcgttaa cggatgttca gcaagcctac     7740

ctggtcgggc gccagccggg atttgccctg ggcggtgtag gctcgcattt cttcgtggaa     7800

ttcgagatcg cagatctcga catacaccgc ctggaaaaag tgtggaaccg tttaattgca     7860

cgtcatgata tgttgcgcgc tgtggttcgt gacggtcagc aacgtgtact ggaacagacc     7920

ccgccatggg tcataccagc acatattctt cacagtcctg aagaggcatt acaggttcgt     7980

gatcgtttag ctcaccaagt gttgaacccc gaagtctggc cggtatttga tctgcaggtg     8040

ggcttcgttg acggtatgcc ggcccgttta tggttgtgcc ttgataacct gttattggac     8100

gggctgagca tgcagattct tctctctgaa ctggagcatg gatatcgcta cccacagcaa     8160

ctccctcccc cgttgccgat cacttttcgc gattatcttc agcaaccggc actccgtacc     8220

ccaaatcctg actcattggc ttggtggcag acgcaactgg atgacatccc acctgcgccc     8280

gccctcccgc tacgttgtct gcctcaagat gttgaaaccc cgcgtttcgc gcgtctgtac     8340

ggcgcaatgg attctgctcg ttggcgtcgc ctgaaacagc gtgcggccga cgcacatctg     8400

actccgtcag ctgtcctact gagcgtatgg tctacagtgc tggcagcttg gtcggcgcag     8460

ccggatttta ctctcaacct gacattattc gaccggcgac cactgcaccc tcagattaat     8520

caaatccttg gcgattttac ctcactgatg ttattgtcgt ggcatccggg tgagagttgg     8580

ctgcagtccg cgcgtcttct ccagcaacgc ctttcagaat cgctcaacca ccgtgatgtt     8640

agcgccattc gcgtcatgcg gcagctggcg agaaggcaaa atgtcccggc cgtacccatg     8700

ccggtcgtat ttacctctgc gctggggttt gaacaggata acttcctggc ccgtcgcaat     8760

ctactgaaac cggtgtgggg tatcagtcag acgccgcaag tttggctgga ccatcaggtc     8820

tatgaatccg agggcgaact gcgttttaac tgggatttcg ttgcggccct gtttccggac     8880

ggtcaagtgg aacgtcagtt cgcgcaatac tgcgccttat tgaatcgcat ggcagaagat     8940

gacagctctt ggcagttgcc gcttgctgat ctggtgcccc cgttaaaagt gaccgagcgg     9000

cgagcgagaa ggctgcgtcc agaacgcgcc cagcctcgta ttgcagctga taagagttcc     9060

gttagtctga tctgtgacac ttttcgtgag gtggttgggg aacccgtggc accggctgag     9120

aactttttcg aagcgggagc cacatccctc aatctggttc agctgcatgt ccttctccaa     9180

cgtcacgaat ttgcgacctt aacgctactg gatttgttca cccatccaag ccctgttgca     9240

ttggctaact atcttgcggg tgtggccctg gaagagaaaa cgaagcgcgt gcggccggtt     9300

cggcgaagac agcgtcgcat tcagcacttg cccttagtag ctgcgcaacc tggaatatgg     9360

atggccgaga agttatctga actaccatca gcgtggagcg tagcgcatta cgtggagctc     9420

actggtgagg ttgactcgcc tcttttggcc agggcggtag tggctggcct tgcacaagct     9480

gacaccttaa gaatgcgttt cacagaggat aatggggaag tttggcaatg ggtagacgat     9540

gcgttaacat ttgagttacc ggaaatcata gacctgcgca ctaacataga ccctcacggg     9600

acagctcagg ccttgatgca agcggacctg caacaggacc tacgtgtgga ttcggggaag     9660

cctctggtct tccatcagct aattcaagta gcggacaatc gctggtactg gtatcaaagg     9720

taccaccact tgcttgtgga cgggttcagt tttccagcga taaccaggca aatagccaac     9780

atttattgca cttggttgcg aggagagcct acgcccgcat cccccttcac gccattcgca     9840

gacgttgttg aggaatacca acagtatcgc gagagcgaag cgtggcaacg cgatgcggca     9900

ttctgggcgg agcaacgacg gcaactaccg cctcccgcat ccctatcacc tgccccgctc     9960

cccggccggt ccgcgtcagc cgacattcta cggctaaagc tggagttcac agatggtgaa    10020

tttcgacagc ttgctacaca actcagcggg gtacaaagga cagacctagc gctcgctctg    10080

gctgcattat ggctaggacg actttgcaat cgaatggact acgcggcggg tttcatattt    10140

atgcgccggc tcggcagcgc agcgttgacc gcaacgggtc cagttttaaa tgttcttcct    10200

ttgggaatcc acataggcaa cccaagcttc tctgagcttc tcaccagggt tcgcgaggtc    10260

gccttaggcg cgtatgcaca ccaacatatt ccttttgaga tgttagtaga ggcactgcaa    10320

ccagagcgaa accttagcca tactcctctc ttccaagtga tgtttgtcct tcagaatgcg    10380

cccgcgtccc aattagagtt aaccgggatc accgcaaacc caattaaggt taaatcaact    10440

accacgaagt tcgacctaac tttaatcatg caaaacacag ctagcggatt agtaggtgtt    10500

tgggagtaca acacggattt attcgacgcg tcaacgattg agcgaatgac agggcacttt    10560

gtaaccctcc tcgagggcgt tatcgccaat ccacaacagc cgatctctca acttcctatt    10620

ttaactacag tggagcaaca gcaactttta gtcgagtgga ataacacgca aaccgactac    10680

cccgctgata agtgtataca tcaattattc gaggaacagg tcgagcgcac accagacgcc    10740

gttgctgtcg tctttgggaa tcagcaactc agctatcgag agatgcgcga acaagtggtt    10800

gcactcgcca atttattacg tgagcgggga gtcaagccag gagactccgt tgccgtggcc    10860

ttaccacgct ctgttttctt aacccttgca ctacacgcga ttgtcgaggc aggtgccgcc    10920

tggctacctc ttgacacagg atatcctgac gatagattaa aaatgatgct cgaggatgca    10980

cggccttccc ttctgatcac aacagacgat caattacccc gcttcagtga cgtacctaat    11040

ctgacctcac tctgttacaa cgctcccttg acgcctcaag ggagcgcccc tttacagctg    11100

tctcaacctc accatactgc atatatcatc tttacaagtg gttctacggg acgccccaag    11160

ggagtaatgg ttggtcagac tgcgattgta aatcgtctgt tgtggatgca aaaccactac    11220

cctttgacgg gggaggacgt tgtagcccaa aagactcctt gctcgttcga tgtctcagtc    11280

tgggagttct tttggccatt tatagcaggg gccaaattag ttatggcgga gccggaagcc    11340

caccgagacc cacttgcgat gcagcaattc tttgctgagt atggtgtcac cactacacat    11400

ttcgtcccat cgatgttagc ggccttcgtg gcttctctta ctccacaaac ggctaggcaa    11460

tcttgtgcca cactaaagca agtcttctgc tccggcgagg cattacctgc agacttgtgc    11520

cgggaatggc agcaactcac aggagctcca ttgcacaatc tatacggacc gaccgaggcc    11580

gcagtagacg tatcttggta tcctgcgttt ggcgaggagt tagcgcaagt aagaggttcg    11640

tcagtaccaa taggataccc cgtatggaac acggggcttc ggatactgga cgcgatgatg    11700

catccggtcc caccaggagt cgcgggcgat ttatacctga ctgggataca gctggcccaa    11760

ggttacctag ggagacctga ccttacggcg tcgaggttca tagcggatcc gtttgctccg    11820

ggtgagcgca tgtaccgtac gggcgacgtc gcgcgatggc tagataatgg cgccgtagag    11880

tatcttggta gatcagacga tcagttaaag atacggggac aacgaataga gcttggggaa    11940

atagaccggg taatgcaggc tttgccagat gtcgagcaag cggtggcttc gtgtgctatt    12000

gcgcgggagg acatacctgg gaacaaacac cttgtagcgt acatagttcc tcaagaggag    12060

caaacatgca ctgagcgatc gaggtccaca cttacagttt cgttcgtccg gagtttcctt    12120

aaggagaaac tccccgaata tatggtaccg agcgcaatag tgattctaga cgctctcccc    12180

ctgactccta atggaaagct agaccggcgg gcgttacccg cccctgacct gcactcacaa    12240

cttgagacaa ttattgctgc ggctttctcg agcctgctcg ggtgcgacgt acaagacgcg    12300

gatgctgact ttttcgcgct aggtggccat tcgctgcttg ccatgaagct agccgctcag    12360

ctttcccgac aagtagcgcg gcaggtgaca ccaggccaag ttatggtagc ttcgactgtc    12420

gcaaagctcg caacgatcat agacgcggag ttagataaat acgtcgctcc aaggaacccg    12480

ataacatccg gggaagataa ccctatcccc ctatgtcaag gcgatgggga ggagatgagc    12540

acatggctac gtcgttttgg acccccagtc gaacatcggg ccaggctagt gtgtttcccc    12600

cacgcaggcg cagcggcgga ttcatactta gacctagcaa gagcgttagc accagagatc    12660

gatgttcatg ctgttcaata ccccggcagg caagacagaa gggacgagga gccattagga    12720

accgcaggtg aaattgcaga tgaagtggca gcggtgctac gtgcgtcggg aggggatggg    12780

ccttttgcac ttttcggcca cagtatgggc gccctcatcg cgtacgagac agcaaggcga    12840

ttagagaggg aaccgggagg gggaccctta cgtttattcg tgagcggaca aacagcgcca    12900

cgtgtccatg aacgaagaac tgatctgccc ggtgacgatg gactcgtgga cgagcttagg    12960

cgacttggca cctccgaggc agcgctcgca gacgaagccc tgctggctat gtctctcccg    13020

gtgctcaggg cggattatag ggtgttaaga tcctacgctt gggcggatgg tcccccacta    13080

cgcgccggta taactgccct ctgcggtgat gcagacccac taactgcaac aggggatgcg    13140

gaacgctggt tacaacattc cgtgattccg ggtcggacac ggacatttcc cggtgggcat    13200

ttttatttag gggaacaagt gaccgaggtg gcaggggctg tccgtagaga tttactgaga    13260

gcagggttag cgggttga                                                  13278


<210>  25
<211>  11616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOC

<400>  25
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctactgc cagtagaaca gccttttgtg cactcaccgg aagagcggta tcgaccattc     6060

gcgttaacgg atgttcagca agcctacctg gtcgggcgcc agccgggatt tgccctgggc     6120

ggtgtaggct cgcatttctt cgtggaattc gagatcgcag atctcgacat acaccgcctg     6180

gaaaaagtgt ggaaccgttt aattgcacgt catgatatgt tgcgcgctgt ggttcgtgac     6240

ggtcagcaac gtgtactgga acagaccccg ccatgggtca taccagcaca tattcttcac     6300

agtcctgaag aggcattaca ggttcgtgat cgtttagctc accaagtgtt gaaccccgaa     6360

gtctggccgg tatttgatct gcaggtgggc ttcgttgacg gtatgccggc ccgtttatgg     6420

ttgtgccttg ataacctgtt attggacggg ctgagcatgc agattcttct ctctgaactg     6480

gagcatggat atcgctaccc acagcaactc cctcccccgt tgccgatcac ttttcgcgat     6540

tatcttcagc aaccggcact ccgtacccca aatcctgact cattggcttg gtggcagacg     6600

caactggatg acatcccacc tgcgcccgcc ctcccgctac gttgtctgcc tcaagatgtt     6660

gaaaccccgc gtttcgcgcg tctgtacggc gcaatggatt ctgctcgttg gcgtcgcctg     6720

aaacagcgtg cggccgacgc acatctgact ccgtcagctg tcctactgag cgtatggtct     6780

acagtgctgg cagcttggtc ggcgcagccg gattttactc tcaacctgac attattcgac     6840

cggcgaccac tgcaccctca gattaatcaa atccttggcg attttacctc actgatgtta     6900

ttgtcgtggc atccgggtga gagttggctg cagtccgcgc gtcttctcca gcaacgcctt     6960

tcagaatcgc tcaaccaccg tgatgttagc gccattcgcg tcatgcggca gctggcgaga     7020

aggcaaaatg tcccggccgt acccatgccg gtcgtattta cctctgcgct ggggtttgaa     7080

caggataact tcctggcccg tcgcaatcta ctgaaaccgg tgtggggtat cagtcagacg     7140

ccgcaagttt ggctggacca tcaggtctat gaatccgagg gcgaactgcg ttttaactgg     7200

gatttcgttg cggccctgtt tccggacggt caagtggaac gtcagttcgc gcaatactgc     7260

gccttattga atcgcatggc agaagatgac agctcttggc agttgccgct tgctgatctg     7320

gtgcccccgt taaaagtgac cgagcggcga gcgagaaggc tgcgtccaga acgcgcccag     7380

cctcgtattg cagctgataa gagttccgtt agtctgatct gtgacacttt tcgtgaggtg     7440

gttggggaac ccgtggcacc ggctgagaac tttttcgaag cgggagccac atccctcaat     7500

ctggttcagc tgcatgtcct tctccaacgt cacgaatttg cgaccttaac gctactggat     7560

ttgttcaccc atccaagccc tgttgcattg gctaactatc ttgcgggtgt ggccctggaa     7620

gagaaaacga agcgcgtgcg gccggttcgg cgaagacagc gtcgcattgg agagccgttc     7680

ccactcgctc ctatgcaaca cgccatgtgg gtagggcggc acgaccacca acagctcggg     7740

ggagtagcag gccatcttta cgtcgagttt gacggcgcga gagtcgaccc cgatcggttg     7800

cgcgctgccg ccacccgact cgccctacgt caccctatgt tgagggtaca gttcctgcct     7860

gacggtacac aaaggatccc tccagccgca ggctcgcggg actttcccat cagcgttgcg     7920

gatcttcgtc acgtagctcc tgacgttgtc gatcaacggc tcgcgggtat tagagacgca     7980

aagtctcatc aacagcttga tggagctgtc ttcgagttgg ctctcactct cctgccaggt     8040

gaaaggacga ggctgcacgt cgacctggat atgcaagctg ctgacgccat gagctacagg     8100

atcctgctgg cggacttggc cgcactatac gacgggagag agcccccagc actcggttac     8160

acgtatagag agtaccgcca ggctattgag gccgaggaaa cattaccgca acctgttcgc     8220

gacgccgata gggactggtg ggcacaaaga ataccacagc ttccagaccc gcccgcacta     8280

ccgacgcgtg ccggtggtga gagagatcgc cggcgctcga ccagaagatg gcactggtta     8340

gacccacaaa caagggacgc cctcttcgca cgagcacgag ctcgtggcat cacacctgca     8400

atgacacttg cggccgcgtt tgcaaatgtc ctcgcgagat ggtccgcctc ttcccggttc     8460

ttactcaatt tgcccctttt ctcgcgccaa gcgttgcatc cggacgtaga cctcttggta     8520

ggtgacttca catcgtcgct gctgttagat gttgacctag gagatacagt gtctaatctt     8580

gctcggaaga accaactgac ttttacggag gactgggaac accggcattg gagcggagta     8640

gagttgctgc gagaactcaa aaggcaacag cgttacccac acggagcgcc cgtggtgttc     8700

acttctaatc ttgggcgcag tttatattct tctcgggcgg agtccccctt gggagagcct     8760

gaatggggaa tttcgcaaac accacaggtt tggatcgacc atttagcatt tgagcaccat     8820

ggggaagtat ggctccaatg ggactcgaac gacgccctct tcccacctgc tttagtcgag     8880

actctgtttg acgcgtactg tcaattgata aaccagctgt gcgacgatga atccgcatgg     8940

caaaagccct tcgcggacat gatgccggcg agtcagcgtg ctattcgtga gcgggtgaac     9000

gctaccggcg caccgatccc ggagggcctc ttacacgaag ggatttttcg gatcgctctt     9060

caacagcctc aggcgctcgc ggtaacggac atgcggtacc aatggaatag ttatcgagag     9120

atgcgggaac aggtcgtcgc tttggcaaat ctactccgag agcgcggggt caagccaggg     9180

gactcagtcg ctgtagcgct tcctcggtca gtcttcctaa ccttggctct ccacgcgatc     9240

gtagaggcgg gtgcggcgtg gcttcccctc gacacgggct atccggacga tcggttgaag     9300

atgatgctag aggatgcacg accctctctg ttaatcacaa ccgacgatca actccccagg     9360

ttctcagacg tccctaatct taccagtcta tgttacaacg cgcccctcac tccacaaggc     9420

agcgctcctt tacaacttag tcagccgcac cataccgctt atatcatttt tacgtccggt     9480

tccacgggca ggccgaaggg tgtaatggtg ggccaaactg caatagtgaa tagactattg     9540

tggatgcaaa accactaccc gcttaccggg gaggacgtag tggctcaaaa gactccctgc     9600

tctttcgatg tcagcgtgtg ggagttcttt tggcctttta tagccggcgc taaattggtt     9660

atggcggagc cggaagctca ccgagaccct ttggccatgc aacagttctt tgcagagtat     9720

ggagtcacaa cgacgcattt cgtcccatcg atgttagccg cgttcgtagc atcattgacg     9780

ccacaaactg cgagacagtc atgtgccaca cttaagcaag tcttctgctc tggtgaggcc     9840

cttcctgcgg acctatgtcg ggaatggcaa cagcttactg gagccccctt gcacaatctt     9900

tacgggccga ctgaggccgc agttgacgta tcgtggtatc cagcgttcgg ggaggagcta     9960

gcccaagtgc gagggtctag tgttccaatt ggatacccgg tgtggaacac agggttaagg    10020

atcctcgacg ccatgatgca tccggtacca ccaggtgtcg ctggggattt gtacctgact    10080

ggcattcaac tggcacaggg ttatctaggg cggcctgact taacagctag ccgattcata    10140

gcagatccat tcgctcccgg agagcggatg taccgaacag gcgacgtggc acgctggtta    10200

gataatggcg ctgtcgagta tcttgggcgg tcagacgatc agttaaagat acgtggacaa    10260

cggattgagc ttggtgaaat agaccgagtt atgcaggcac taccagatgt cgagcaagcc    10320

gtagcctctt gtgccattgc gcgagaagac attcccggga acaagcactt ggttgcgtac    10380

atagtgccgc aagaggagca gacctgcaca gagcggtcac gttcaactct cacagtttcc    10440

ttcgtccgtt ctttcttaaa ggagaaacta ccagaatata tggtaccgtc cgcgatcgtg    10500

atattagacg ctctgccact cacgccaaat ggaaagttgg atagaagagc tctgcctgct    10560

cctgacttgc actcgcaact cctggataaa tacgttgctc ccagaaaccc aatagagact    10620

attatcgcgg cagcattctc ttcattgctt ggatgcgacg tccaagatgc ggacgcagat    10680

ttctttgcgc tcgggggcca tagtctattg gccatgaagc tcgcagcgca attgtcgaga    10740

caggtagcac ggcaagtaac gcccgggcaa gtcatggtcg cctcgacagt cgcgaaactc    10800

gcgaccatta tcgacgctga gacatccggg gaagataacc ctatccccct atgtcaaggc    10860

gatggggagg agatgagcac atggctacgt cgttttggac ccccagtcga acatcgggcc    10920

aggctagtgt gtttccccca cgcaggcgca gcggcggatt catacttaga cctagcaaga    10980

gcgttagcac cagagatcga tgttcatgct gttcaatacc ccggcaggca agacagaagg    11040

gacgaggagc cattaggaac cgcaggtgaa attgcagatg aagtggcagc ggtgctacgt    11100

gcgtcgggag gggatgggcc ttttgcactt ttcggccaca gtatgggcgc cctcatcgcg    11160

tacgagacag caaggcgatt agagagggaa ccgggagggg gacccttacg tttattcgtg    11220

agcggacaaa cagcgccacg tgtccatgaa cgaagaactg atctgcccgg tgacgatgga    11280

ctcgtggacg agcttaggcg acttggcacc tccgaggcag cgctcgcaga cgaagccctg    11340

ctggctatgt ctctcccggt gctcagggcg gattataggg tgttaagatc ctacgcttgg    11400

gcggatggtc ccccactacg cgccggtata actgccctct gcggtgatgc agacccacta    11460

actgcaacag gggatgcgga acgctggtta caacattccg tgattccggg tcggacacgg    11520

acatttcccg gtgggcattt ttatttaggg gaacaagtga ccgaggtggc aggggctgtc    11580

cgtagagatt tactgagagc agggttagcg ggttga                              11616


<210>  26
<211>  12939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOH

<400>  26
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctacctg gaattggggc gctagttccc gctcccgtgg taatcgcagc aggccgtacg     6060

gaggaaccaa ttgccatagt atccatggct tgccggttac ccggtggtgt gaatacccca     6120

cagagactat gggaattatt acgtgaaggg ggagaaaccc tcagtggctt ccctaccgac     6180

cgagggtggg acctcgcgag gttgcatcac ccagacccag acaaccccgg tacgtcatac     6240

gttgataaag ggggattcct ggacgatgcg gcagggtttg acgcagaatt tttcggtgtg     6300

agccccagag aagcagcggc tatggacccg cagcagagat tactcctcga aaccagctgg     6360

gagttagtcg agaatgcagg gattgatcca catagcctaa gggggaccgc cactggtgtc     6420

ttcctcggcg ttgccaagtt tgggtatggc gaggatacgg cagctgccga agacgtcgag     6480

gggtactctg tcactggtgt agccccggca gtggcgtcgg gcagaattag ttacacgatg     6540

gggttggaag ggccgtctat ttcggttgat accgcctgtt cctccagtct ggttgcactc     6600

caccttgcag tcgagtcgct ccggaaagga gaaagcagta tggccgtggt cgggggagcg     6660

gcggtgatgg ccacaccggg tgtgtttgtg gatttttccc gacagagagc cttggccgcg     6720

gatgggcgtt caaaggcgtt cggagcaggt gcagacgggt ttggatttag cgaaggtgtg     6780

acactggttc tcctagaaag attaagtgaa gcccggcgta acggccatga ggtgctggca     6840

gttgttagag gttccgcatt aaaccaggac ggggcttcga acgggctgag cgccccctcg     6900

ggcccggcac agagaagagt gatacgccaa gcactcgaat cgtgtggcct agaaccaggt     6960

gacgttgacg cggtggaagc gcacgggaca ggaactgcgt taggggaccc gatagaagca     7020

aacgccttgc tggacactta tggtagagat cgtgatgcgg atcgacccct ctggttagga     7080

agtgttaagt caaatatagg acacactcag gcagcggcgg gagtaactgg gctgctcaaa     7140

gtagtcctag ccttacgcaa tggggaacta cccgccaccc tacatgtcga ggaaccgaca     7200

ccgcatgtgg attggtcgag cgggggagtt gctctcttgg cgggtaatca gccgtggcga     7260

agaggtgaac gaacccgtag agccgccgtg tccgcattcg ggatcagtgg tacgaacgcg     7320

cacgtgattg tggaagaagc tccacaagag gtgagaccag cgcccggtca aggactctcg     7380

cccgcggtgt caaccttggt agtggcgggt aaaactatgc agcgtgtttc ggcaaccgcc     7440

ggtatgctcg cagattggat ggaaggccca ggtgcagatg tggcgctggc ggacgtggcg     7500

cacacgttaa atcatcaccg ttcacggcaa ccaaagttcg gtacggtggt ggccagggac     7560

cggacacagg caatcgccgg actaagagcg ctggcggcgg gtcagcacgc cccaggggtt     7620

gttaaccctg ctgaaggaag tccaggtcca gggacggtgt tcgtgtttcc tggccagggg     7680

tcccagcgtg caggcatggg ggaggagttg gctgcggctt tccccgtgtt tgccagaatc     7740

caccagcaag tgtgggattt actcgatgtt cctgatctcg acgttaacga aacggggtac     7800

gcacaaccag cactcttcgc actccaagtg gcgctgtttg ggctcctcga atcatgggga     7860

gtacggccgg atgccgtggt cgggcatagt gtaggggaat tagcggcagg gtacgtttcc     7920

gggctttgga gtcttgagga tgcttgcacg ctcgtgtcgg cgagagcccg tctaatgcaa     7980

gccttaccgg caggtggtgt tatggcggca gttccagtgt ccgaagacga agcacgggct     8040

gtgttggggg aaggagtcga aatagctgcg gtcaacggtc cgtcgagcgt ggttctaagc     8100

ggtgatgaag cagcagtgct ccaggccgcg gaagggttag gcaagtggac gcgattaccg     8160

acctcgcatg cattccattc tgctcgtatg gaaccaatgc tggaagagtt tagagcagtg     8220

gcggaaggtc taacatacag gactccccag gtggcaatgg ccgccggaga ccaggttatg     8280

accgctgaat actgggtgcg tcaggttagg gatacagttc gttttggcga gcaagttgcc     8340

tcgttcgagg atgctgtatt cgtggaattg ggagcagatc gctctcttgc acggctagtc     8400

gatggtatcg cgatgttgca cggggatcat gaggcacagg ctggtatgcg gagagaacaa     8460

cccttgccct taggtttacg aagattgcta accgacctgc ataacgctgg tgctgccgtc     8520

gattttagtg ttttgtgccc acaaggtcgt ctggttgacg caccgttacc agcctggtca     8580

caccggtttc tcttctatga ccgggaagga gtggacaata gatcaccagg gggaagcaca     8640

gtggcggtcc acccgctttt actagccgcg gtggatgtgc cgggccacgg tggagcggtt     8700

ttcacgggta gactctcgac tgacgagcaa ccgtggttag cggagcacgt tgtcggggga     8760

agaaccctag ttcctggttc tgttttagtc gatctagcct tagcggcagg cgaagacgta     8820

gggctaccgg tgttagaaga attagtattg cagaggccgc tggtgcttgc cggcgcggga     8880

gcactcctac ggatgtcggt cggggcacca gacgagagcg gtagaagaac tatcgatgtt     8940

cacgcagctg aagacgtcgc cgatttagca gatgcccaat ggtcccagca cgccaccggg     9000

actttagccc aaggggtagc ggcggggccc agggacacag agcaatggcc cccagaggat     9060

gccgtccgga ttccattaga cgaccattat gatggtctcg cggaacaggg ttatgagtac     9120

ggtccgtcgt ttcaggcgct agtggcctac gtggcggagg atgcgactgc gacaatgtta     9180

gcggaagtcg cgcttccggg cagcattaga tcgcaacaag gtctatacgc catccatccc     9240

gcactgctgg acgcttgttt tcaatctgtc ggagcccacc cagacagtca atccgtcggg     9300

tcaggtctac tcgtacccct cggtgttcgg agagttcgtg cgtacgcacc cgtaaggacc     9360

gcccgttatt gttacacccg cgtcacgaaa gttgaactag ctggggttga ggccgacatc     9420

gacgttctgg atgctcacgg cacagtgctt ctagccgtgt gcggtcttcg tatcgggacc     9480

ggagtgagcg agagggacaa acacaacaga gttctcaatg agcgcctact caccatcgaa     9540

tggcatcagc gtgaactacc agaaatggac ccctcgggtg ccgggaagtg gctcctaatc     9600

tcggactgtg cagcatccga tgtcaccgct acacgactgg ctgatgcctt ccgggagcac     9660

agcgctgcgt gcactaccat gcggtggcca cttcacgatg atcaactagc agccgccgac     9720

caactccggg accaggtggg ttcagatgag ttttctggcg tggtagtact aacagggcca     9780

aacacaggga cccctcatca gggttccgca gaccgtggcg ccgagtacgt taggcggtta     9840

gttggaatcg ctcgtgaact tagcgatctt cccggagcgg ttccccgtat gtatgtcgtc     9900

acaaggggag cgcagagagt ccttgccgat gattgtgtta atttagaaca gggagggctc     9960

agaggtctgc tgaggaccat cggtgctgag cacccacatc tccgcgccac ccaaattgat    10020

gttgatgagc agacaggagt agagcagctg gcgcgacaac tcctagctac atcggaggaa    10080

gacgagacag cctggaggga caacgaatgg tacgttgcga ggttatgccc cacacccctg    10140

aggccacagg aacgtaggac aatagtggcg gaccatcaac agtctggtat gcggttacaa    10200

atacgtacgc ccggtgcaat cgatagtgtg gcctttgaac ccgcacccga tgtagagcaa    10260

cccttacggg cgggtgaagt tcgggttgac gttagagcaa ccggtgttaa tttccgtgac    10320

gttctactcg ctctcgggat gtatccccag aaagctgaca tggggacaga agcagctggt    10380

gttgtaacag cagtgggacc tgatgtcgat gcgtttgcgc ctggtgatag agttctaggg    10440

ctattccaag gggcatttgc tccaattgcg gtgactgacc atcgtttact ggcacgggtg    10500

ccagacgggt ggtcagatgc cgatgcggcg gcggtgccaa tagcttacac gacagcacat    10560

tatgcgctgc acgacctggc ggggttgcgg gcggggcaat ctgtcctgat acacgcggca    10620

gcgggtggtg ttggtatggc cgctgttgca ctggcacgga gggccggcgc agaagttctg    10680

gctaccgcag gacctgcaaa acacggtacg ctacgggcat tagggctaga tgatgaacac    10740

atcgcttcga gtcgggagac cgggttcgcg cgtaagttcc gagagcggac tgggggacga    10800

ggagtggacg tcgttctaaa cagcttgacc ggcgaactat tagacgagtc cgcggatctc    10860

ctcgcggagg acggagtctt cgtggaaatg ggaaagactg atctgcgcga tgcaggggac    10920

tttcgtgggc gctacgcccc gtttgatcta ggggaagcag gcgatgacag gctcggggaa    10980

attctacgtg aggtggtggg actgctcggt gcaggggaac tcgaccgact ccctgttagc    11040

gcgtgggaat tggggatacc ccagacgggg aagtcgttag tgacgctgcc acccgaacaa    11100

gcgcaagttt tcagaccaga cggcactgta ttgatcaccg ggggaacggg aacgttaggt    11160

cggctgctgg cccgtcatct ggttacagag cacggggtgc gtcacctgct gctagtgtcg    11220

aggagaggag cagatgcccc tggatcggac gagctgaggg ccgaaatcga ggatctcgga    11280

gcatcagcgg aaattgcagc atgtgataca gccgatcgag acgctctcag cgcgttgcta    11340

gatggactgc cgaggccact gaccggagta gttcacgccg cgggagtcct cgctgacggt    11400

ctggttacat ccatcgacga gcccgcagtc gaacaagttc tccgtgcaaa agttgatgcg    11460

gcctggaacc tgcacgagct aactgcgaac accggtctca gctttttcgt gctgttctcg    11520

tcagccgcaa gtgtgttagc ggggccgggg cagggagtat atgcggcagc gaacgaatct    11580

ttaaacgctc tggccgctct gcgtaggact aggggtttac ccgcaaaagc attgggatgg    11640

ggattatggg cgatagggcg tgcaatagca tttgccgagc agaccggtga cgcaatcgcc    11700

ccggaggaag gcgcgtacgc cttcgagaca ctactcagac ataacagggc gtactcgggt    11760

tacgctcccg tgatagggtc accatggctg actgcgttcg cccaacattc gccctttgcg    11820

gagaagttcc agtccctggg gcaaaataga tccgggacgt ctaagtttct ggcagaatta    11880

gtcgatctgc caagagaaga atggccagat cggttacgtc gtctattaga actggtgagg    11940

tctcatgctg ccgcagtttc ggggtatgga tcggcagacc aattaccaga aagaaaagca    12000

ttcaaagacc tcggattcga ttcactggca gcagtcgaac taagaaatcg tctagggacc    12060

gcgacaggcg tccggctgcc cagtactctg gtgttcgacc acccaacccc acttgcggtt    12120

gcggaacatc tacgtgatcg tctaacatcc ggggaagata accctatccc cctatgtcaa    12180

ggcgatgggg aggagatgag cacatggcta cgtcgttttg gacccccagt cgaacatcgg    12240

gccaggctag tgtgtttccc ccacgcaggc gcagcggcgg attcatactt agacctagca    12300

agagcgttag caccagagat cgatgttcat gctgttcaat accccggcag gcaagacaga    12360

agggacgagg agccattagg aaccgcaggt gaaattgcag atgaagtggc agcggtgcta    12420

cgtgcgtcgg gaggggatgg gccttttgca cttttcggcc acagtatggg cgccctcatc    12480

gcgtacgaga cagcaaggcg attagagagg gaaccgggag ggggaccctt acgtttattc    12540

gtgagcggac aaacagcgcc acgtgtccat gaacgaagaa ctgatctgcc cggtgacgat    12600

ggactcgtgg acgagcttag gcgacttggc acctccgagg cagcgctcgc agacgaagcc    12660

ctgctggcta tgtctctccc ggtgctcagg gcggattata gggtgttaag atcctacgct    12720

tgggcggatg gtcccccact acgcgccggt ataactgccc tctgcggtga tgcagaccca    12780

ctaactgcaa caggggatgc ggaacgctgg ttacaacatt ccgtgattcc gggtcggaca    12840

cggacatttc ccggtgggca tttttattta ggggaacaag tgaccgaggt ggcaggggct    12900

gtccgtagag atttactgag agcagggtta gcgggttga                           12939


<210>  27
<211>  11286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOO

<400>  27
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctacctg gaattggggc gctagttccc gctcccgtgg taatcgcagc aggccgtacg     6060

gaggaaccaa ttgccatcgt ttcgatggca tgtcgtttac cgggaggagt caatacgccc     6120

caacggctct gggaattact acgggagggt ggtgaaacct tgtccgggtt cccaacggac     6180

cgtggctggg acctagcacg gcttcaccac cctgatccgg acaaccccgg aacgagctac     6240

gttgataagg gtggatttct cgacgacgcg gcgggtttcg acgcagagtt tttcggggtt     6300

tcaccaaggg aagctgccgc tatggaccct cagcaacgat tacttttaga gacctcgtgg     6360

gagctagttg aaaatgcggg catagatcca catagcctgc gagggacagc gacaggggtg     6420

ttcctaggag ttgcgaagtt tggttatggt gaggacacag cagcagcgga agatgttgaa     6480

ggttattcag ttaccggtgt tgctcccgct gtggcatctg gccgcatatc ctacactatg     6540

ggtttagaag gtccttccat ctcggtcgat accgcatgct caagctcgct agtcgcgctt     6600

catctagccg tagagtccct ccgaaagggt gagtcatcta tggcggtggt gggtggtgca     6660

gccgttatgg cgactcctgg ggtatttgtt gatttttcac gccaacgggc gcttgccgca     6720

gacggccgtt ccaaagcgtt cggggcaggt gcagatggtt ttggtttcag cgagggagtc     6780

acgctggttc tactagagcg tttaagtgag gcgcgtcgta acggtcatga agttctagct     6840

gtagtgcgcg ggtccgcgtt aaaccaggac ggagcgagca acggactttc agcaccctcc     6900

ggccctgcgc aacgtagagt aataaggcaa gcgctcgaat cgtgtgggct tgaaccgggg     6960

gatgttgacg cggttgaggc gcatggtact ggtacagcac taggtgaccc aatagaggcc     7020

aatgcgctgt tggacactta cgggcgagac cgtgatgcgg atcgtccact ttggttgggg     7080

tccgttaaga gcaatattgg gcacactcaa gctgcggccg gggttacagg actgctgaag     7140

gttgtgttag cactgcgcaa tggtgagcta cctgcaacgt tacatgtcga ggaaccaact     7200

ccacacgtcg attggtcctc aggtggtgtc gcattactgg cgggtaatca accatggcga     7260

aggggagaaa ggaccagaag ggcggcagtg agcgcctttg gtatctccgg tacaaatgct     7320

cacgtgatag tggaagaggc gcctcaggaa gttcgacccg cccctggcca agggctgtcg     7380

ccagccgtgt ccacgttagt tgttgcaggt aaaaccatgc agcgtgtaag tgcgacagct     7440

ggaatgcttg cagactggat ggagggtcct ggggccgatg ttgcattggc ggatgtggcc     7500

cataccctga accatcaccg atcaagacag cccaagttcg ggacggttgt agcgcgtgac     7560

aggactcagg cgatagctgg gctccgtgca ttggcggctg gtcaacatgc tcctggggtc     7620

gtcaacccag ctgaaggttc cccaggacca ggcaccgtgt tcgtttttcc cggtcaaggt     7680

tcgcagaggg cagggatggg ggaggaactc gcggcagcct ttcctgtctt cgctcgaata     7740

catcagcaag tttgggacct cctagatgtt cccgacctcg acgttaatga aaccgggtac     7800

gcccaaccag cgctgttcgc gcttcaggtc gcgctctttg gccttctgga gtcgtggggt     7860

gttaggccag atgcagtggt agggcactca gttggtgagc tggccgcggg gtacgtgtcc     7920

ggtctttggt cactagagga cgcctgcaca ctagtctcag caagagcgcg cctaatgcag     7980

gcactgcctg ctggaggggt gatggcggca gtccccgtct ccgaggatga ggcgcgggcc     8040

gtcctgggcg agggagttga aattgcggct gtgaatggac cctcgtccgt tgtgctctca     8100

ggggacgagg cggcagtctt acaggccgcc gaaggtctag gtaagtggac gcgactgccg     8160

accagccatg cttttcactc agcgagaatg gaacccatgc tagaagagtt tcgggccgta     8220

gcagagggtc tgacctatcg tacccctcaa gtagctatgg ctgctgggga tcaggtgatg     8280

acagcagaat attgggtgcg gcaggttcgg gacacagttc gcttcgggga gcaagtagcg     8340

tcattcgagg atgcggtgtt tgttgagtta ggcgctgaca gaagtctagc gcgtttggtg     8400

gacggcatcg ccatgctgca cggtgaccac gaagcgcagg ccgcggacca taggcaaatc     8460

accgaagcgg ttgcggatgc ttacgtctta ggccaccttc cggattttgc ggcgctgcgg     8520

cggcctcacg cacgaaagtt ggacttacca acttatccct tcgagcgtag acagtactgg     8580

ttcagagatg cgcgtgagag gccggaacaa cccagagata ccggcggacc tcgcacagaa     8640

gcagtccgtc tgttagagga tggtaggatt gaagaattag ctgcactttt gggaggggcc     8700

agtgatgacc aacacacatt acaggtgctg actaagttgg cggcgcaaca taaccaacaa     8760

cgaacaaccc ggtcaatcgc tgacgacagg tacgaaataa ggtgggaccg atcgacttcc     8820

ccactatccg gagcagatgt tgaccaagcg gggagctgga tcgtggtgtc agatgacgca     8880

gatgccgttc ccccgctagt ggacttgctg gctgcacgta acgagcccca tcaggttgtt     8940

ggtctacccg cttcggacgc agacgaggag aggctcgcag agactctgcg tgcggctgcg     9000

actgaagatg ctacccttcg gatagtccac gttgcggcgc tcgaagcagg cgctaccccc     9060

agcatgcgtt cactgctccg catgcagcac cgaatactag gtggcacgcg gcgggtgttc     9120

agggcagcgg tcgcagcgga gttaagaggt cccatttgga tagtgacgcg gggagcacaa     9180

agagtggctg acaccgatac agttgccccg catcagtcat gcctctgggg atttgggagg     9240

gcagcatcgc tggagctgcc gcacgtttgg ggtggcctag cagatttatc agagggcggt     9300

gacaatgcgg ccgatgagtg gagtgcgcta gtggaccgca ttgccgcacc ccacggttca     9360

gcagttaggg aggaccaact ggcgctgaga gacagggccg tatatacgcc aagactggcc     9420

agacgttctg cgcccccgag cgggactccc ctacatctac gaggggatgg cacagtgtta     9480

ataacaggtg ggactggtac actaggtagg ctattagcgc gtcacctagt aacagagcat     9540

ggggtgcggc atctcttact agtttcaagg agaggcgccg atgcccctgg ctcggatgaa     9600

ctgcgcgcag aaatagagga cttaggtgcc agcgcggaga tcgcagcgtg tgatacagcg     9660

gatcgcgatg ccctatctgc cctactagat ggtctccccc ggccccttac gggtgtcgtt     9720

cacgccgctg gcgtgttagc cgatggactt gtcactagca ttgacgagcc tgcggtggaa     9780

caggttctcc gagcaaaggt ggacgcggca tggaacctac acgaactcac agctaatacc     9840

gggctatcct ttttcgttct tttctcatca gcagcatcgg tcctggcagg tccagggcaa     9900

ggagtttatg cggctgcaaa tgaatcgctc aacgcactag ctgcgttaag gcgaactagg     9960

ggtctgccgg ccaaggctct gggatggggc ctgtgggcca tcgggcgggc aatcgctttt    10020

gcggagcaga ccggggacgc catcgctcca gaggaaggag catacgcttt tgaaactctg    10080

ttaaggcata accgtgccta ctcgggatat gcgcccgtca ttggatctcc ctggttgacc    10140

gcgttcgcac agcattcccc ctttgcagaa aaattccaat cactcggaca gaatcggtca    10200

gggacatcga aattcttagc ggagctagtt gacctgcctc gtgaggaatg gccggatagg    10260

ctcaggagac tactagagtt agttaggtcc catgccgccg cggtctccgg ttacggtagt    10320

gcagatcaac tgccggaaag aaaagcgttc aaggatttgg ggtttgattc gctggccgcc    10380

gttgaactgc gtaaccggct gggaacggct acaggggtac gactgccgtc aaccctagta    10440

tttgatcacc caactccgct ggccgtcgct gagcacttaa gagataggct aacatccggg    10500

gaagataacc ctatccccct atgtcaaggc gatggggagg agatgagcac atggctacgt    10560

cgttttggac ccccagtcga acatcgggcc aggctagtgt gtttccccca cgcaggcgca    10620

gcggcggatt catacttaga cctagcaaga gcgttagcac cagagatcga tgttcatgct    10680

gttcaatacc ccggcaggca agacagaagg gacgaggagc cattaggaac cgcaggtgaa    10740

attgcagatg aagtggcagc ggtgctacgt gcgtcgggag gggatgggcc ttttgcactt    10800

ttcggccaca gtatgggcgc cctcatcgcg tacgagacag caaggcgatt agagagggaa    10860

ccgggagggg gacccttacg tttattcgtg agcggacaaa cagcgccacg tgtccatgaa    10920

cgaagaactg atctgcccgg tgacgatgga ctcgtggacg agcttaggcg acttggcacc    10980

tccgaggcag cgctcgcaga cgaagccctg ctggctatgt ctctcccggt gctcagggcg    11040

gattataggg tgttaagatc ctacgcttgg gcggatggtc ccccactacg cgccggtata    11100

actgccctct gcggtgatgc agacccacta actgcaacag gggatgcgga acgctggtta    11160

caacattccg tgattccggg tcggacacgg acatttcccg gtgggcattt ttatttaggg    11220

gaacaagtga ccgaggtggc aggggctgtc cgtagagatt tactgagagc agggttagcg    11280

ggttga                                                               11286


<210>  28
<211>  11625
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MOS

<400>  28
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctactgc cagtagaaca gccttttgtg cactcaccgg aagagcggta tcgaccattc     6060

gcgttaacgg atgttcagca agcctacctg gtcgggcgcc agccgggatt tgccctgggc     6120

ggtgtaggct cgcatttctt cgtggaattc gagatcgcag atctcgacat acaccgcctg     6180

gaaaaagtgt ggaaccgttt aattgcacgt catgatatgt tgcgcgctgt ggttcgtgac     6240

ggtcagcaac gtgtactgga acagaccccg ccatgggtca taccagcaca tattcttcac     6300

agtcctgaag aggcattaca ggttcgtgat cgtttagctc accaagtgtt gaaccccgaa     6360

gtctggccgg tatttgatct gcaggtgggc ttcgttgacg gtatgccggc ccgtttatgg     6420

ttgtgccttg ataacctgtt attggacggg ctgagcatgc agattcttct ctctgaactg     6480

gagcatggat atcgctaccc acagcaactc cctcccccgt tgccgatcac ttttcgcgat     6540

tatcttcagc aaccggcact ccgtacccca aatcctgact cattggcttg gtggcagacg     6600

caactggatg acatcccacc tgcgcccgcc ctcccgctac gttgtctgcc tcaagatgtt     6660

gaaaccccgc gtttcgcgcg tctgtacggc gcaatggatt ctgctcgttg gcgtcgcctg     6720

aaacagcgtg cggccgacgc acatctgact ccgtcagctg tcctactgag cgtatggtct     6780

acagtgctgg cagcttggtc ggcgcagccg gattttactc tcaacctgac attattcgac     6840

cggcgaccac tgcaccctca gattaatcaa atccttggcg attttacctc actgatgtta     6900

ttgtcgtggc atccgggtga gagttggctg cagtccgcgc gtcttctcca gcaacgcctt     6960

tcagaatcgc tcaaccaccg tgatgttagc gccattcgcg tcatgcggca gctggcgaga     7020

aggcaaaatg tcccggccgt acccatgccg gtcgtattta cctctgcgct ggggtttgaa     7080

caggataact tcctggcccg tcgcaatcta ctgaaaccgg tgtggggtat cagtcagacg     7140

ccgcaagttt ggctggacca tcaggtctat gaatccgagg gcgaactgcg ttttaactgg     7200

gatttcgttg cggccctgtt tccggacggt caagtggaac gtcagttcgc gcaatactgc     7260

gccttattga atcgcatggc agaagatgac agctcttggc agttgccgct tgctgatctg     7320

gtgcccccgt taaaagtgac cgagcggcga gcgagaaggc tgcgtccaga acgcgcccag     7380

cctcgtattg cagctgataa gagttccgtt agtctgatct gtgacacttt tcgtgaggtg     7440

gttggggaac ccgtggcacc ggctgagaac tttttcgaag cgggagccac atccctcaat     7500

ctggttcagc tgcatgtcct tctccaacgt cacgaatttg cgaccttaac gctactggat     7560

ttgttcaccc atccaagccc tgttgcattg gctaactatc ttgcgggtgt ggccctggaa     7620

gagaaaacga agcgcgtgcg gccggttcgg cgaagacagc gtcgcattca gcacttgccc     7680

ttagtagctg cgcaacctgg aatatggatg gccgagaagt tatctgaact accatcagcg     7740

tggagcgtag cgcattacgt ggagctcact ggtgaggttg actcgcctct tttggccagg     7800

gcggtagtgg ctggccttgc acaagctgac accttaagaa tgcgtttcac agaggataat     7860

ggggaagttt ggcaatgggt agacgatgcg ttaacatttg agttaccgga aatcatagac     7920

ctgcgcacta acatagaccc tcacgggaca gctcaggcct tgatgcaagc ggacctgcaa     7980

caggacctac gtgtggattc ggggaagcct ctggtcttcc atcagctaat tcaagtagcg     8040

gacaatcgct ggtactggta tcaaaggtac caccacttgc ttgtggacgg gttcagtttt     8100

ccagcgataa ccaggcaaat agccaacatt tattgcactt ggttgcgagg agagcctacg     8160

cccgcatccc ccttcacgcc attcgcagac gttgttgagg aataccaaca gtatcgcgag     8220

agcgaagcgt ggcaacgcga tgcggcattc tgggcggagc aacgacggca actaccgcct     8280

cccgcatccc tatcacctgc cccgctcccc ggccggtccg cgtcagccga cattctacgg     8340

ctaaagctgg agttcacaga tggtgaattt cgacagcttg ctacacaact cagcggggta     8400

caaaggacag acctagcgct cgctctggct gcattatggc taggacgact ttgcaatcga     8460

atggactacg cggcgggttt catatttatg cgccggctcg gcagcgcagc gttgaccgca     8520

acgggtccag ttttaaatgt tcttcctttg ggaatccaca taggcaaccc aagcttctct     8580

gagcttctca ccagggttcg cgaggtcgcc ttaggcgcgt atgcacacca acatattcct     8640

tttgagatgt tagtagaggc actgcaacca gagcgaaacc ttagccatac tcctctcttc     8700

caagtgatgt ttgtccttca gaatgcgccc gcgtcccaat tagagttaac cgggatcacc     8760

gcaaacccaa ttaaggttaa atcaactacc acgaagttcg acctaacttt aatcatgcaa     8820

aacacagcta gcggattagt aggtgtttgg gagtacaaca cggatttatt cgacgcgtca     8880

acgattgagc gaatgacagg gcactttgta accctcctcg agggcgttat cgccaatcca     8940

caacagccga tctctcaact tcctatttta actacagtgg agcaacagca acttttagtc     9000

gagtggaata acacgcaaac cgactacccc gctgataagt gtatacatca attattcgag     9060

gaacaggtcg agcgcacacc agacgccgtt gctgtcgtct ttgggaatca gcaactcagc     9120

tatcgagaga tgcgcgaaca agtggttgca ctcgccaatt tattacgtga gcggggagtc     9180

aagccaggag actccgttgc cgtggcctta ccacgctctg ttttcttaac ccttgcacta     9240

cacgcgattg tcgaggcagg tgccgcctgg ctacctcttg acacaggata tcctgacgat     9300

agattaaaaa tgatgctcga ggatgcacgg ccttcccttc tgatcacaac agacgatcaa     9360

ttaccccgct tcagtgacgt acctaatctg acctcactct gttacaacgc tcccttgacg     9420

cctcaaggga gcgccccttt acagctgtct caacctcacc atactgcata tatcatcttt     9480

acaagtggtt ctacgggacg ccccaaggga gtaatggttg gtcagactgc gattgtaaat     9540

cgtctgttgt ggatgcaaaa ccactaccct ttgacggggg aggacgttgt agcccaaaag     9600

actccttgct cgttcgatgt ctcagtctgg gagttctttt ggccatttat agcaggggcc     9660

aaattagtta tggcggagcc ggaagcccac cgagacccac ttgcgatgca gcaattcttt     9720

gctgagtatg gtgtcaccac tacacatttc gtcccatcga tgttagcggc cttcgtggct     9780

tctcttactc cacaaacggc taggcaatct tgtgccacac taaagcaagt cttctgctcc     9840

ggcgaggcat tacctgcaga cttgtgccgg gaatggcagc aactcacagg agctccattg     9900

cacaatctat acggaccgac cgaggccgca gtagacgtat cttggtatcc tgcgtttggc     9960

gaggagttag cgcaagtaag aggttcgtca gtaccaatag gataccccgt atggaacacg    10020

gggcttcgga tactggacgc gatgatgcat ccggtcccac caggagtcgc gggcgattta    10080

tacctgactg ggatacagct ggcccaaggt tacctaggga gacctgacct tacggcgtcg    10140

aggttcatag cggatccgtt tgctccgggt gagcgcatgt accgtacggg cgacgtcgcg    10200

cgatggctag ataatggcgc cgtagagtat cttggtagat cagacgatca gttaaagata    10260

cggggacaac gaatagagct tggggaaata gaccgggtaa tgcaggcttt gccagatgtc    10320

gagcaagcgg tggcttcgtg tgctattgcg cgggaggaca tacctgggaa caaacacctt    10380

gtagcgtaca tagttcctca agaggagcaa acatgcactg agcgatcgag gtccacactt    10440

acagtttcgt tcgtccggag tttccttaag gagaaactcc ccgaatatat ggtaccgagc    10500

gcaatagtga ttctagacgc tctccccctg actcctaatg gaaagctaga ccggcgggcg    10560

ttacccgccc ctgacctgca ctcacaactt gagacaatta ttgctgcggc tttctcgagc    10620

ctgctcgggt gcgacgtaca agacgcggat gctgactttt tcgcgctagg tggccattcg    10680

ctgcttgcca tgaagctagc cgctcagctt tcccgacaag tagcgcggca ggtgacacca    10740

ggccaagtta tggtagcttc gactgtcgca aagctcgcaa cgatcataga cgcggagtta    10800

gataaatacg tcgctccaag gaacccgata acatccgggg aagataaccc tatcccccta    10860

tgtcaaggcg atggggagga gatgagcaca tggctacgtc gttttggacc cccagtcgaa    10920

catcgggcca ggctagtgtg tttcccccac gcaggcgcag cggcggattc atacttagac    10980

ctagcaagag cgttagcacc agagatcgat gttcatgctg ttcaataccc cggcaggcaa    11040

gacagaaggg acgaggagcc attaggaacc gcaggtgaaa ttgcagatga agtggcagcg    11100

gtgctacgtg cgtcgggagg ggatgggcct tttgcacttt tcggccacag tatgggcgcc    11160

ctcatcgcgt acgagacagc aaggcgatta gagagggaac cgggaggggg acccttacgt    11220

ttattcgtga gcggacaaac agcgccacgt gtccatgaac gaagaactga tctgcccggt    11280

gacgatggac tcgtggacga gcttaggcga cttggcacct ccgaggcagc gctcgcagac    11340

gaagccctgc tggctatgtc tctcccggtg ctcagggcgg attatagggt gttaagatcc    11400

tacgcttggg cggatggtcc cccactacgc gccggtataa ctgccctctg cggtgatgca    11460

gacccactaa ctgcaacagg ggatgcggaa cgctggttac aacattccgt gattccgggt    11520

cggacacgga catttcccgg tgggcatttt tatttagggg aacaagtgac cgaggtggca    11580

ggggctgtcc gtagagattt actgagagca gggttagcgg gttga                    11625


<210>  29
<211>  11970
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSC

<400>  29
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcca gcacttgccc ttagtagctg cgcaacctgg aatatggatg     3240

gccgagaagt tatctgaact accatcagcg tggagcgtag cgcattacgt ggagctcact     3300

ggtgaggttg actcgcctct tttggccagg gcggtagtgg ctggccttgc acaagctgac     3360

accttaagaa tgcgtttcac agaggataat ggggaagttt ggcaatgggt agacgatgcg     3420

ttaacatttg agttaccgga aatcatagac ctgcgcacta acatagaccc tcacgggaca     3480

gctcaggcct tgatgcaagc ggacctgcaa caggacctac gtgtggattc ggggaagcct     3540

ctggtcttcc atcagctaat tcaagtagcg gacaatcgct ggtactggta tcaaaggtac     3600

caccacttgc ttgtggacgg gttcagtttt ccagcgataa ccaggcaaat agccaacatt     3660

tattgcactt ggttgcgagg agagcctacg cccgcatccc ccttcacgcc attcgcagac     3720

gttgttgagg aataccaaca gtatcgcgag agcgaagcgt ggcaacgcga tgcggcattc     3780

tgggcggagc aacgacggca actaccgcct cccgcatccc tatcacctgc cccgctcccc     3840

ggccggtccg cgtcagccga cattctacgg ctaaagctgg agttcacaga tggtgaattt     3900

cgacagcttg ctacacaact cagcggggta caaaggacag acctagcgct cgctctggct     3960

gcattatggc taggacgact ttgcaatcga atggactacg cggcgggttt catatttatg     4020

cgccggctcg gcagcgcagc gttgaccgca acgggtccag ttttaaatgt tcttcctttg     4080

ggaatccaca taggcaaccc aagcttctct gagcttctca ccagggttcg cgaggtcgcc     4140

ttaggcgcgt atgcacacca acatattcct tttgagatgt tagtagaggc actgcaacca     4200

gagcgaaacc ttagccatac tcctctcttc caagtgatgt ttgtccttca gaatgcgccc     4260

gcgtcccaat tagagttaac cgggatcacc gcaaacccaa ttaaggttaa atcaactacc     4320

acgaagttcg acctaacttt aatcatgcaa aacacagcta gcggattagt aggtgtttgg     4380

gagtacaaca cggatttatt cgacgcgtca acgattgagc gaatgacagg gcactttgta     4440

accctcctcg agggcgttat cgccaatcca caacagccga tctctcaact tcctatttta     4500

actacagtgg agcaacagca acttttagtc gagtggaata acacgcaaac cgactacccc     4560

gctgataagt gtatacatca attattcgag gaacaggtcg agcgcacacc agacgccgtt     4620

gctgtcgtct ttgggaatca gcaactcagc tatcgagaga tgcgcgaaca agtggttgca     4680

ctcgccaatt tattacgtga gcggggagtc aagccaggag actccgttgc cgtggcctta     4740

ccacgctctg ttttcttaac ccttgcacta cacgcgattg tcgaggcagg tgccgcctgg     4800

ctacctcttg acacaggata tcctgacgat agattaaaaa tgatgctcga ggatgcacgg     4860

ccttcccttc tgatcacaac agacgatcaa ttaccccgct tcagtgacgt acctaatctg     4920

acctcactct gttacaacgc tcccttgacg cctcaaggga gcgccccttt acagctgtct     4980

caacctcacc atactgcata tatcatcttt acaagtggtt ctacgggacg ccccaaggga     5040

gtaatggttg gtcagactgc gattgtaaat cgtctgttgt ggatgcaaaa ccactaccct     5100

ttgacggggg aggacgttgt agcccaaaag actccttgct cgttcgatgt ctcagtctgg     5160

gagttctttt ggccatttat agcaggggcc aaattagtta tggcggagcc ggaagcccac     5220

cgagacccac ttgcgatgca gcaattcttt gctgagtatg gtgtcaccac tacacatttc     5280

gtcccatcga tgttagcggc cttcgtggct tctcttactc cacaaacggc taggcaatct     5340

tgtgccacac taaagcaagt cttctgctcc ggcgaggcat tacctgcaga cttgtgccgg     5400

gaatggcagc aactcacagg agctccattg cacaatctat acggaccgac cgaggccgca     5460

gtagacgtat cttggtatcc tgcgtttggc gaggagttag cgcaagtaag aggttcgtca     5520

gtaccaatag gataccccgt atggaacacg gggcttcgga tactggacgc gatgatgcat     5580

ccggtcccac caggagtcgc gggcgattta tacctgactg ggatacagct ggcccaaggt     5640

tacctaggga gacctgacct tacggcgtcg aggttcatag cggatccgtt tgctccgggt     5700

gagcgcatgt accgtacggg cgacgtcgcg cgatggctag ataatggcgc cgtagagtat     5760

cttggtagat cagacgatca gttaaagata cggggacaac gaatagagct tggggaaata     5820

gaccgggtaa tgcaggcttt gccagatgtc gagcaagcgg tggcttcgtg tgctattgcg     5880

cgggaggaca tacctgggaa caaacacctt gtagcgtaca tagttcctca agaggagcaa     5940

acatgcactg agcgatcgag gtccacactt acagtttcgt tcgtccggag tttccttaag     6000

gagaaactcc ccgaatatat ggtaccgagc gcaatagtga ttctagacgc tctccccctg     6060

actcctaatg gaaagctaga ccggcgggcg ttacccgccc ctgacctgca ctcacaactt     6120

gagacaatta ttgctgcggc tttctcgagc ctgctcgggt gcgacgtaca agacgcggat     6180

gctgactttt tcgcgctagg tggccattcg ctgcttgcca tgaagctagc cgctcagctt     6240

tcccgacaag tagcgcggca ggtgacacca ggccaagtta tggtagcttc gactgtcgca     6300

aagctcgcaa cgatcataga cgcggagtta gataaatacg tcgctccaag gaacccgata     6360

ctgccagtag aacagccttt tgtgcactca ccggaagagc ggtatcgacc attcgcgtta     6420

acggatgttc agcaagccta cctggtcggg cgccagccgg gatttgccct gggcggtgta     6480

ggctcgcatt tcttcgtgga attcgagatc gcagatctcg acatacaccg cctggaaaaa     6540

gtgtggaacc gtttaattgc acgtcatgat atgttgcgcg ctgtggttcg tgacggtcag     6600

caacgtgtac tggaacagac cccgccatgg gtcataccag cacatattct tcacagtcct     6660

gaagaggcat tacaggttcg tgatcgttta gctcaccaag tgttgaaccc cgaagtctgg     6720

ccggtatttg atctgcaggt gggcttcgtt gacggtatgc cggcccgttt atggttgtgc     6780

cttgataacc tgttattgga cgggctgagc atgcagattc ttctctctga actggagcat     6840

ggatatcgct acccacagca actccctccc ccgttgccga tcacttttcg cgattatctt     6900

cagcaaccgg cactccgtac cccaaatcct gactcattgg cttggtggca gacgcaactg     6960

gatgacatcc cacctgcgcc cgccctcccg ctacgttgtc tgcctcaaga tgttgaaacc     7020

ccgcgtttcg cgcgtctgta cggcgcaatg gattctgctc gttggcgtcg cctgaaacag     7080

cgtgcggccg acgcacatct gactccgtca gctgtcctac tgagcgtatg gtctacagtg     7140

ctggcagctt ggtcggcgca gccggatttt actctcaacc tgacattatt cgaccggcga     7200

ccactgcacc ctcagattaa tcaaatcctt ggcgatttta cctcactgat gttattgtcg     7260

tggcatccgg gtgagagttg gctgcagtcc gcgcgtcttc tccagcaacg cctttcagaa     7320

tcgctcaacc accgtgatgt tagcgccatt cgcgtcatgc ggcagctggc gagaaggcaa     7380

aatgtcccgg ccgtacccat gccggtcgta tttacctctg cgctggggtt tgaacaggat     7440

aacttcctgg cccgtcgcaa tctactgaaa ccggtgtggg gtatcagtca gacgccgcaa     7500

gtttggctgg accatcaggt ctatgaatcc gagggcgaac tgcgttttaa ctgggatttc     7560

gttgcggccc tgtttccgga cggtcaagtg gaacgtcagt tcgcgcaata ctgcgcctta     7620

ttgaatcgca tggcagaaga tgacagctct tggcagttgc cgcttgctga tctggtgccc     7680

ccgttaaaag tgaccgagcg gcgagcgaga aggctgcgtc cagaacgcgc ccagcctcgt     7740

attgcagctg ataagagttc cgttagtctg atctgtgaca cttttcgtga ggtggttggg     7800

gaacccgtgg caccggctga gaactttttc gaagcgggag ccacatccct caatctggtt     7860

cagctgcatg tccttctcca acgtcacgaa tttgcgacct taacgctact ggatttgttc     7920

acccatccaa gccctgttgc attggctaac tatcttgcgg gtgtggccct ggaagagaaa     7980

acgaagcgcg tgcggccggt tcggcgaaga cagcgtcgca ttggagagcc gttcccactc     8040

gctcctatgc aacacgccat gtgggtaggg cggcacgacc accaacagct cgggggagta     8100

gcaggccatc tttacgtcga gtttgacggc gcgagagtcg accccgatcg gttgcgcgct     8160

gccgccaccc gactcgccct acgtcaccct atgttgaggg tacagttcct gcctgacggt     8220

acacaaagga tccctccagc cgcaggctcg cgggactttc ccatcagcgt tgcggatctt     8280

cgtcacgtag ctcctgacgt tgtcgatcaa cggctcgcgg gtattagaga cgcaaagtct     8340

catcaacagc ttgatggagc tgtcttcgag ttggctctca ctctcctgcc aggtgaaagg     8400

acgaggctgc acgtcgacct ggatatgcaa gctgctgacg ccatgagcta caggatcctg     8460

ctggcggact tggccgcact atacgacggg agagagcccc cagcactcgg ttacacgtat     8520

agagagtacc gccaggctat tgaggccgag gaaacattac cgcaacctgt tcgcgacgcc     8580

gatagggact ggtgggcaca aagaatacca cagcttccag acccgcccgc actaccgacg     8640

cgtgccggtg gtgagagaga tcgccggcgc tcgaccagaa gatggcactg gttagaccca     8700

caaacaaggg acgccctctt cgcacgagca cgagctcgtg gcatcacacc tgcaatgaca     8760

cttgcggccg cgtttgcaaa tgtcctcgcg agatggtccg cctcttcccg gttcttactc     8820

aatttgcccc ttttctcgcg ccaagcgttg catccggacg tagacctctt ggtaggtgac     8880

ttcacatcgt cgctgctgtt agatgttgac ctaggagata cagtgtctaa tcttgctcgg     8940

aagaaccaac tgacttttac ggaggactgg gaacaccggc attggagcgg agtagagttg     9000

ctgcgagaac tcaaaaggca acagcgttac ccacacggag cgcccgtggt gttcacttct     9060

aatcttgggc gcagtttata ttcttctcgg gcggagtccc ccttgggaga gcctgaatgg     9120

ggaatttcgc aaacaccaca ggtttggatc gaccatttag catttgagca ccatggggaa     9180

gtatggctcc aatgggactc gaacgacgcc ctcttcccac ctgctttagt cgagactctg     9240

tttgacgcgt actgtcaatt gataaaccag ctgtgcgacg atgaatccgc atggcaaaag     9300

cccttcgcgg acatgatgcc ggcgagtcag cgtgctattc gtgagcgggt gaacgctacc     9360

ggcgcaccga tcccggaggg cctcttacac gaagggattt ttcggatcgc tcttcaacag     9420

cctcaggcgc tcgcggtaac ggacatgcgg taccaatgga atagttatcg agagatgcgg     9480

gaacaggtcg tcgctttggc aaatctactc cgagagcgcg gggtcaagcc aggggactca     9540

gtcgctgtag cgcttcctcg gtcagtcttc ctaaccttgg ctctccacgc gatcgtagag     9600

gcgggtgcgg cgtggcttcc cctcgacacg ggctatccgg acgatcggtt gaagatgatg     9660

ctagaggatg cacgaccctc tctgttaatc acaaccgacg atcaactccc caggttctca     9720

gacgtcccta atcttaccag tctatgttac aacgcgcccc tcactccaca aggcagcgct     9780

cctttacaac ttagtcagcc gcaccatacc gcttatatca tttttacgtc cggttccacg     9840

ggcaggccga agggtgtaat ggtgggccaa actgcaatag tgaatagact attgtggatg     9900

caaaaccact acccgcttac cggggaggac gtagtggctc aaaagactcc ctgctctttc     9960

gatgtcagcg tgtgggagtt cttttggcct tttatagccg gcgctaaatt ggttatggcg    10020

gagccggaag ctcaccgaga ccctttggcc atgcaacagt tctttgcaga gtatggagtc    10080

acaacgacgc atttcgtccc atcgatgtta gccgcgttcg tagcatcatt gacgccacaa    10140

actgcgagac agtcatgtgc cacacttaag caagtcttct gctctggtga ggcccttcct    10200

gcggacctat gtcgggaatg gcaacagctt actggagccc ccttgcacaa tctttacggg    10260

ccgactgagg ccgcagttga cgtatcgtgg tatccagcgt tcggggagga gctagcccaa    10320

gtgcgagggt ctagtgttcc aattggatac ccggtgtgga acacagggtt aaggatcctc    10380

gacgccatga tgcatccggt accaccaggt gtcgctgggg atttgtacct gactggcatt    10440

caactggcac agggttatct agggcggcct gacttaacag ctagccgatt catagcagat    10500

ccattcgctc ccggagagcg gatgtaccga acaggcgacg tggcacgctg gttagataat    10560

ggcgctgtcg agtatcttgg gcggtcagac gatcagttaa agatacgtgg acaacggatt    10620

gagcttggtg aaatagaccg agttatgcag gcactaccag atgtcgagca agccgtagcc    10680

tcttgtgcca ttgcgcgaga agacattccc gggaacaagc acttggttgc gtacatagtg    10740

ccgcaagagg agcagacctg cacagagcgg tcacgttcaa ctctcacagt ttccttcgtc    10800

cgttctttct taaaggagaa actaccagaa tatatggtac cgtccgcgat cgtgatatta    10860

gacgctctgc cactcacgcc aaatggaaag ttggatagaa gagctctgcc tgctcctgac    10920

ttgcactcgc aactcctgga taaatacgtt gctcccagaa acccaataga gactattatc    10980

gcggcagcat tctcttcatt gcttggatgc gacgtccaag atgcggacgc agatttcttt    11040

gcgctcgggg gccatagtct attggccatg aagctcgcag cgcaattgtc gagacaggta    11100

gcacggcaag taacgcccgg gcaagtcatg gtcgcctcga cagtcgcgaa actcgcgacc    11160

attatcgacg ctgagacatc cggggaagat aaccctatcc ccctatgtca aggcgatggg    11220

gaggagatga gcacatggct acgtcgtttt ggacccccag tcgaacatcg ggccaggcta    11280

gtgtgtttcc cccacgcagg cgcagcggcg gattcatact tagacctagc aagagcgtta    11340

gcaccagaga tcgatgttca tgctgttcaa taccccggca ggcaagacag aagggacgag    11400

gagccattag gaaccgcagg tgaaattgca gatgaagtgg cagcggtgct acgtgcgtcg    11460

ggaggggatg ggccttttgc acttttcggc cacagtatgg gcgccctcat cgcgtacgag    11520

acagcaaggc gattagagag ggaaccggga gggggaccct tacgtttatt cgtgagcgga    11580

caaacagcgc cacgtgtcca tgaacgaaga actgatctgc ccggtgacga tggactcgtg    11640

gacgagctta ggcgacttgg cacctccgag gcagcgctcg cagacgaagc cctgctggct    11700

atgtctctcc cggtgctcag ggcggattat agggtgttaa gatcctacgc ttgggcggat    11760

ggtcccccac tacgcgccgg tataactgcc ctctgcggtg atgcagaccc actaactgca    11820

acaggggatg cggaacgctg gttacaacat tccgtgattc cgggtcggac acggacattt    11880

cccggtgggc atttttattt aggggaacaa gtgaccgagg tggcaggggc tgtccgtaga    11940

gatttactga gagcagggtt agcgggttga                                     11970


<210>  30
<211>  13293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSH

<400>  30
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcca gcacttgccc ttagtagctg cgcaacctgg aatatggatg     3240

gccgagaagt tatctgaact accatcagcg tggagcgtag cgcattacgt ggagctcact     3300

ggtgaggttg actcgcctct tttggccagg gcggtagtgg ctggccttgc acaagctgac     3360

accttaagaa tgcgtttcac agaggataat ggggaagttt ggcaatgggt agacgatgcg     3420

ttaacatttg agttaccgga aatcatagac ctgcgcacta acatagaccc tcacgggaca     3480

gctcaggcct tgatgcaagc ggacctgcaa caggacctac gtgtggattc ggggaagcct     3540

ctggtcttcc atcagctaat tcaagtagcg gacaatcgct ggtactggta tcaaaggtac     3600

caccacttgc ttgtggacgg gttcagtttt ccagcgataa ccaggcaaat agccaacatt     3660

tattgcactt ggttgcgagg agagcctacg cccgcatccc ccttcacgcc attcgcagac     3720

gttgttgagg aataccaaca gtatcgcgag agcgaagcgt ggcaacgcga tgcggcattc     3780

tgggcggagc aacgacggca actaccgcct cccgcatccc tatcacctgc cccgctcccc     3840

ggccggtccg cgtcagccga cattctacgg ctaaagctgg agttcacaga tggtgaattt     3900

cgacagcttg ctacacaact cagcggggta caaaggacag acctagcgct cgctctggct     3960

gcattatggc taggacgact ttgcaatcga atggactacg cggcgggttt catatttatg     4020

cgccggctcg gcagcgcagc gttgaccgca acgggtccag ttttaaatgt tcttcctttg     4080

ggaatccaca taggcaaccc aagcttctct gagcttctca ccagggttcg cgaggtcgcc     4140

ttaggcgcgt atgcacacca acatattcct tttgagatgt tagtagaggc actgcaacca     4200

gagcgaaacc ttagccatac tcctctcttc caagtgatgt ttgtccttca gaatgcgccc     4260

gcgtcccaat tagagttaac cgggatcacc gcaaacccaa ttaaggttaa atcaactacc     4320

acgaagttcg acctaacttt aatcatgcaa aacacagcta gcggattagt aggtgtttgg     4380

gagtacaaca cggatttatt cgacgcgtca acgattgagc gaatgacagg gcactttgta     4440

accctcctcg agggcgttat cgccaatcca caacagccga tctctcaact tcctatttta     4500

actacagtgg agcaacagca acttttagtc gagtggaata acacgcaaac cgactacccc     4560

gctgataagt gtatacatca attattcgag gaacaggtcg agcgcacacc agacgccgtt     4620

gctgtcgtct ttgggaatca gcaactcagc tatcgagaga tgcgcgaaca agtggttgca     4680

ctcgccaatt tattacgtga gcggggagtc aagccaggag actccgttgc cgtggcctta     4740

ccacgctctg ttttcttaac ccttgcacta cacgcgattg tcgaggcagg tgccgcctgg     4800

ctacctcttg acacaggata tcctgacgat agattaaaaa tgatgctcga ggatgcacgg     4860

ccttcccttc tgatcacaac agacgatcaa ttaccccgct tcagtgacgt acctaatctg     4920

acctcactct gttacaacgc tcccttgacg cctcaaggga gcgccccttt acagctgtct     4980

caacctcacc atactgcata tatcatcttt acaagtggtt ctacgggacg ccccaaggga     5040

gtaatggttg gtcagactgc gattgtaaat cgtctgttgt ggatgcaaaa ccactaccct     5100

ttgacggggg aggacgttgt agcccaaaag actccttgct cgttcgatgt ctcagtctgg     5160

gagttctttt ggccatttat agcaggggcc aaattagtta tggcggagcc ggaagcccac     5220

cgagacccac ttgcgatgca gcaattcttt gctgagtatg gtgtcaccac tacacatttc     5280

gtcccatcga tgttagcggc cttcgtggct tctcttactc cacaaacggc taggcaatct     5340

tgtgccacac taaagcaagt cttctgctcc ggcgaggcat tacctgcaga cttgtgccgg     5400

gaatggcagc aactcacagg agctccattg cacaatctat acggaccgac cgaggccgca     5460

gtagacgtat cttggtatcc tgcgtttggc gaggagttag cgcaagtaag aggttcgtca     5520

gtaccaatag gataccccgt atggaacacg gggcttcgga tactggacgc gatgatgcat     5580

ccggtcccac caggagtcgc gggcgattta tacctgactg ggatacagct ggcccaaggt     5640

tacctaggga gacctgacct tacggcgtcg aggttcatag cggatccgtt tgctccgggt     5700

gagcgcatgt accgtacggg cgacgtcgcg cgatggctag ataatggcgc cgtagagtat     5760

cttggtagat cagacgatca gttaaagata cggggacaac gaatagagct tggggaaata     5820

gaccgggtaa tgcaggcttt gccagatgtc gagcaagcgg tggcttcgtg tgctattgcg     5880

cgggaggaca tacctgggaa caaacacctt gtagcgtaca tagttcctca agaggagcaa     5940

acatgcactg agcgatcgag gtccacactt acagtttcgt tcgtccggag tttccttaag     6000

gagaaactcc ccgaatatat ggtaccgagc gcaatagtga ttctagacgc tctccccctg     6060

actcctaatg gaaagctaga ccggcgggcg ttacccgccc ctgacctgca ctcacaactt     6120

gagacaatta ttgctgcggc tttctcgagc ctgctcgggt gcgacgtaca agacgcggat     6180

gctgactttt tcgcgctagg tggccattcg ctgcttgcca tgaagctagc cgctcagctt     6240

tcccgacaag tagcgcggca ggtgacacca ggccaagtta tggtagcttc gactgtcgca     6300

aagctcgcaa cgatcataga cgcggagtta gataaatacg tcgctccaag gaacccgata     6360

cctggaattg gggcgctagt tcccgctccc gtggtaatcg cagcaggccg tacggaggaa     6420

ccaattgcca tagtatccat ggcttgccgg ttacccggtg gtgtgaatac cccacagaga     6480

ctatgggaat tattacgtga agggggagaa accctcagtg gcttccctac cgaccgaggg     6540

tgggacctcg cgaggttgca tcacccagac ccagacaacc ccggtacgtc atacgttgat     6600

aaagggggat tcctggacga tgcggcaggg tttgacgcag aatttttcgg tgtgagcccc     6660

agagaagcag cggctatgga cccgcagcag agattactcc tcgaaaccag ctgggagtta     6720

gtcgagaatg cagggattga tccacatagc ctaaggggga ccgccactgg tgtcttcctc     6780

ggcgttgcca agtttgggta tggcgaggat acggcagctg ccgaagacgt cgaggggtac     6840

tctgtcactg gtgtagcccc ggcagtggcg tcgggcagaa ttagttacac gatggggttg     6900

gaagggccgt ctatttcggt tgataccgcc tgttcctcca gtctggttgc actccacctt     6960

gcagtcgagt cgctccggaa aggagaaagc agtatggccg tggtcggggg agcggcggtg     7020

atggccacac cgggtgtgtt tgtggatttt tcccgacaga gagccttggc cgcggatggg     7080

cgttcaaagg cgttcggagc aggtgcagac gggtttggat ttagcgaagg tgtgacactg     7140

gttctcctag aaagattaag tgaagcccgg cgtaacggcc atgaggtgct ggcagttgtt     7200

agaggttccg cattaaacca ggacggggct tcgaacgggc tgagcgcccc ctcgggcccg     7260

gcacagagaa gagtgatacg ccaagcactc gaatcgtgtg gcctagaacc aggtgacgtt     7320

gacgcggtgg aagcgcacgg gacaggaact gcgttagggg acccgataga agcaaacgcc     7380

ttgctggaca cttatggtag agatcgtgat gcggatcgac ccctctggtt aggaagtgtt     7440

aagtcaaata taggacacac tcaggcagcg gcgggagtaa ctgggctgct caaagtagtc     7500

ctagccttac gcaatgggga actacccgcc accctacatg tcgaggaacc gacaccgcat     7560

gtggattggt cgagcggggg agttgctctc ttggcgggta atcagccgtg gcgaagaggt     7620

gaacgaaccc gtagagccgc cgtgtccgca ttcgggatca gtggtacgaa cgcgcacgtg     7680

attgtggaag aagctccaca agaggtgaga ccagcgcccg gtcaaggact ctcgcccgcg     7740

gtgtcaacct tggtagtggc gggtaaaact atgcagcgtg tttcggcaac cgccggtatg     7800

ctcgcagatt ggatggaagg cccaggtgca gatgtggcgc tggcggacgt ggcgcacacg     7860

ttaaatcatc accgttcacg gcaaccaaag ttcggtacgg tggtggccag ggaccggaca     7920

caggcaatcg ccggactaag agcgctggcg gcgggtcagc acgccccagg ggttgttaac     7980

cctgctgaag gaagtccagg tccagggacg gtgttcgtgt ttcctggcca ggggtcccag     8040

cgtgcaggca tgggggagga gttggctgcg gctttccccg tgtttgccag aatccaccag     8100

caagtgtggg atttactcga tgttcctgat ctcgacgtta acgaaacggg gtacgcacaa     8160

ccagcactct tcgcactcca agtggcgctg tttgggctcc tcgaatcatg gggagtacgg     8220

ccggatgccg tggtcgggca tagtgtaggg gaattagcgg cagggtacgt ttccgggctt     8280

tggagtcttg aggatgcttg cacgctcgtg tcggcgagag cccgtctaat gcaagcctta     8340

ccggcaggtg gtgttatggc ggcagttcca gtgtccgaag acgaagcacg ggctgtgttg     8400

ggggaaggag tcgaaatagc tgcggtcaac ggtccgtcga gcgtggttct aagcggtgat     8460

gaagcagcag tgctccaggc cgcggaaggg ttaggcaagt ggacgcgatt accgacctcg     8520

catgcattcc attctgctcg tatggaacca atgctggaag agtttagagc agtggcggaa     8580

ggtctaacat acaggactcc ccaggtggca atggccgccg gagaccaggt tatgaccgct     8640

gaatactggg tgcgtcaggt tagggataca gttcgttttg gcgagcaagt tgcctcgttc     8700

gaggatgctg tattcgtgga attgggagca gatcgctctc ttgcacggct agtcgatggt     8760

atcgcgatgt tgcacgggga tcatgaggca caggctggta tgcggagaga acaacccttg     8820

cccttaggtt tacgaagatt gctaaccgac ctgcataacg ctggtgctgc cgtcgatttt     8880

agtgttttgt gcccacaagg tcgtctggtt gacgcaccgt taccagcctg gtcacaccgg     8940

tttctcttct atgaccggga aggagtggac aatagatcac cagggggaag cacagtggcg     9000

gtccacccgc ttttactagc cgcggtggat gtgccgggcc acggtggagc ggttttcacg     9060

ggtagactct cgactgacga gcaaccgtgg ttagcggagc acgttgtcgg gggaagaacc     9120

ctagttcctg gttctgtttt agtcgatcta gccttagcgg caggcgaaga cgtagggcta     9180

ccggtgttag aagaattagt attgcagagg ccgctggtgc ttgccggcgc gggagcactc     9240

ctacggatgt cggtcggggc accagacgag agcggtagaa gaactatcga tgttcacgca     9300

gctgaagacg tcgccgattt agcagatgcc caatggtccc agcacgccac cgggacttta     9360

gcccaagggg tagcggcggg gcccagggac acagagcaat ggcccccaga ggatgccgtc     9420

cggattccat tagacgacca ttatgatggt ctcgcggaac agggttatga gtacggtccg     9480

tcgtttcagg cgctagtggc ctacgtggcg gaggatgcga ctgcgacaat gttagcggaa     9540

gtcgcgcttc cgggcagcat tagatcgcaa caaggtctat acgccatcca tcccgcactg     9600

ctggacgctt gttttcaatc tgtcggagcc cacccagaca gtcaatccgt cgggtcaggt     9660

ctactcgtac ccctcggtgt tcggagagtt cgtgcgtacg cacccgtaag gaccgcccgt     9720

tattgttaca cccgcgtcac gaaagttgaa ctagctgggg ttgaggccga catcgacgtt     9780

ctggatgctc acggcacagt gcttctagcc gtgtgcggtc ttcgtatcgg gaccggagtg     9840

agcgagaggg acaaacacaa cagagttctc aatgagcgcc tactcaccat cgaatggcat     9900

cagcgtgaac taccagaaat ggacccctcg ggtgccggga agtggctcct aatctcggac     9960

tgtgcagcat ccgatgtcac cgctacacga ctggctgatg ccttccggga gcacagcgct    10020

gcgtgcacta ccatgcggtg gccacttcac gatgatcaac tagcagccgc cgaccaactc    10080

cgggaccagg tgggttcaga tgagttttct ggcgtggtag tactaacagg gccaaacaca    10140

gggacccctc atcagggttc cgcagaccgt ggcgccgagt acgttaggcg gttagttgga    10200

atcgctcgtg aacttagcga tcttcccgga gcggttcccc gtatgtatgt cgtcacaagg    10260

ggagcgcaga gagtccttgc cgatgattgt gttaatttag aacagggagg gctcagaggt    10320

ctgctgagga ccatcggtgc tgagcaccca catctccgcg ccacccaaat tgatgttgat    10380

gagcagacag gagtagagca gctggcgcga caactcctag ctacatcgga ggaagacgag    10440

acagcctgga gggacaacga atggtacgtt gcgaggttat gccccacacc cctgaggcca    10500

caggaacgta ggacaatagt ggcggaccat caacagtctg gtatgcggtt acaaatacgt    10560

acgcccggtg caatcgatag tgtggccttt gaacccgcac ccgatgtaga gcaaccctta    10620

cgggcgggtg aagttcgggt tgacgttaga gcaaccggtg ttaatttccg tgacgttcta    10680

ctcgctctcg ggatgtatcc ccagaaagct gacatgggga cagaagcagc tggtgttgta    10740

acagcagtgg gacctgatgt cgatgcgttt gcgcctggtg atagagttct agggctattc    10800

caaggggcat ttgctccaat tgcggtgact gaccatcgtt tactggcacg ggtgccagac    10860

gggtggtcag atgccgatgc ggcggcggtg ccaatagctt acacgacagc acattatgcg    10920

ctgcacgacc tggcggggtt gcgggcgggg caatctgtcc tgatacacgc ggcagcgggt    10980

ggtgttggta tggccgctgt tgcactggca cggagggccg gcgcagaagt tctggctacc    11040

gcaggacctg caaaacacgg tacgctacgg gcattagggc tagatgatga acacatcgct    11100

tcgagtcggg agaccgggtt cgcgcgtaag ttccgagagc ggactggggg acgaggagtg    11160

gacgtcgttc taaacagctt gaccggcgaa ctattagacg agtccgcgga tctcctcgcg    11220

gaggacggag tcttcgtgga aatgggaaag actgatctgc gcgatgcagg ggactttcgt    11280

gggcgctacg ccccgtttga tctaggggaa gcaggcgatg acaggctcgg ggaaattcta    11340

cgtgaggtgg tgggactgct cggtgcaggg gaactcgacc gactccctgt tagcgcgtgg    11400

gaattgggga taccccagac ggggaagtcg ttagtgacgc tgccacccga acaagcgcaa    11460

gttttcagac cagacggcac tgtattgatc accgggggaa cgggaacgtt aggtcggctg    11520

ctggcccgtc atctggttac agagcacggg gtgcgtcacc tgctgctagt gtcgaggaga    11580

ggagcagatg cccctggatc ggacgagctg agggccgaaa tcgaggatct cggagcatca    11640

gcggaaattg cagcatgtga tacagccgat cgagacgctc tcagcgcgtt gctagatgga    11700

ctgccgaggc cactgaccgg agtagttcac gccgcgggag tcctcgctga cggtctggtt    11760

acatccatcg acgagcccgc agtcgaacaa gttctccgtg caaaagttga tgcggcctgg    11820

aacctgcacg agctaactgc gaacaccggt ctcagctttt tcgtgctgtt ctcgtcagcc    11880

gcaagtgtgt tagcggggcc ggggcaggga gtatatgcgg cagcgaacga atctttaaac    11940

gctctggccg ctctgcgtag gactaggggt ttacccgcaa aagcattggg atggggatta    12000

tgggcgatag ggcgtgcaat agcatttgcc gagcagaccg gtgacgcaat cgccccggag    12060

gaaggcgcgt acgccttcga gacactactc agacataaca gggcgtactc gggttacgct    12120

cccgtgatag ggtcaccatg gctgactgcg ttcgcccaac attcgccctt tgcggagaag    12180

ttccagtccc tggggcaaaa tagatccggg acgtctaagt ttctggcaga attagtcgat    12240

ctgccaagag aagaatggcc agatcggtta cgtcgtctat tagaactggt gaggtctcat    12300

gctgccgcag tttcggggta tggatcggca gaccaattac cagaaagaaa agcattcaaa    12360

gacctcggat tcgattcact ggcagcagtc gaactaagaa atcgtctagg gaccgcgaca    12420

ggcgtccggc tgcccagtac tctggtgttc gaccacccaa ccccacttgc ggttgcggaa    12480

catctacgtg atcgtctaac atccggggaa gataacccta tccccctatg tcaaggcgat    12540

ggggaggaga tgagcacatg gctacgtcgt tttggacccc cagtcgaaca tcgggccagg    12600

ctagtgtgtt tcccccacgc aggcgcagcg gcggattcat acttagacct agcaagagcg    12660

ttagcaccag agatcgatgt tcatgctgtt caataccccg gcaggcaaga cagaagggac    12720

gaggagccat taggaaccgc aggtgaaatt gcagatgaag tggcagcggt gctacgtgcg    12780

tcgggagggg atgggccttt tgcacttttc ggccacagta tgggcgccct catcgcgtac    12840

gagacagcaa ggcgattaga gagggaaccg ggagggggac ccttacgttt attcgtgagc    12900

ggacaaacag cgccacgtgt ccatgaacga agaactgatc tgcccggtga cgatggactc    12960

gtggacgagc ttaggcgact tggcacctcc gaggcagcgc tcgcagacga agccctgctg    13020

gctatgtctc tcccggtgct cagggcggat tatagggtgt taagatccta cgcttgggcg    13080

gatggtcccc cactacgcgc cggtataact gccctctgcg gtgatgcaga cccactaact    13140

gcaacagggg atgcggaacg ctggttacaa cattccgtga ttccgggtcg gacacggaca    13200

tttcccggtg ggcattttta tttaggggaa caagtgaccg aggtggcagg ggctgtccgt    13260

agagatttac tgagagcagg gttagcgggt tga                                 13293


<210>  31
<211>  11640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSO

<400>  31
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcca gcacttgccc ttagtagctg cgcaacctgg aatatggatg     3240

gccgagaagt tatctgaact accatcagcg tggagcgtag cgcattacgt ggagctcact     3300

ggtgaggttg actcgcctct tttggccagg gcggtagtgg ctggccttgc acaagctgac     3360

accttaagaa tgcgtttcac agaggataat ggggaagttt ggcaatgggt agacgatgcg     3420

ttaacatttg agttaccgga aatcatagac ctgcgcacta acatagaccc tcacgggaca     3480

gctcaggcct tgatgcaagc ggacctgcaa caggacctac gtgtggattc ggggaagcct     3540

ctggtcttcc atcagctaat tcaagtagcg gacaatcgct ggtactggta tcaaaggtac     3600

caccacttgc ttgtggacgg gttcagtttt ccagcgataa ccaggcaaat agccaacatt     3660

tattgcactt ggttgcgagg agagcctacg cccgcatccc ccttcacgcc attcgcagac     3720

gttgttgagg aataccaaca gtatcgcgag agcgaagcgt ggcaacgcga tgcggcattc     3780

tgggcggagc aacgacggca actaccgcct cccgcatccc tatcacctgc cccgctcccc     3840

ggccggtccg cgtcagccga cattctacgg ctaaagctgg agttcacaga tggtgaattt     3900

cgacagcttg ctacacaact cagcggggta caaaggacag acctagcgct cgctctggct     3960

gcattatggc taggacgact ttgcaatcga atggactacg cggcgggttt catatttatg     4020

cgccggctcg gcagcgcagc gttgaccgca acgggtccag ttttaaatgt tcttcctttg     4080

ggaatccaca taggcaaccc aagcttctct gagcttctca ccagggttcg cgaggtcgcc     4140

ttaggcgcgt atgcacacca acatattcct tttgagatgt tagtagaggc actgcaacca     4200

gagcgaaacc ttagccatac tcctctcttc caagtgatgt ttgtccttca gaatgcgccc     4260

gcgtcccaat tagagttaac cgggatcacc gcaaacccaa ttaaggttaa atcaactacc     4320

acgaagttcg acctaacttt aatcatgcaa aacacagcta gcggattagt aggtgtttgg     4380

gagtacaaca cggatttatt cgacgcgtca acgattgagc gaatgacagg gcactttgta     4440

accctcctcg agggcgttat cgccaatcca caacagccga tctctcaact tcctatttta     4500

actacagtgg agcaacagca acttttagtc gagtggaata acacgcaaac cgactacccc     4560

gctgataagt gtatacatca attattcgag gaacaggtcg agcgcacacc agacgccgtt     4620

gctgtcgtct ttgggaatca gcaactcagc tatcgagaga tgcgcgaaca agtggttgca     4680

ctcgccaatt tattacgtga gcggggagtc aagccaggag actccgttgc cgtggcctta     4740

ccacgctctg ttttcttaac ccttgcacta cacgcgattg tcgaggcagg tgccgcctgg     4800

ctacctcttg acacaggata tcctgacgat agattaaaaa tgatgctcga ggatgcacgg     4860

ccttcccttc tgatcacaac agacgatcaa ttaccccgct tcagtgacgt acctaatctg     4920

acctcactct gttacaacgc tcccttgacg cctcaaggga gcgccccttt acagctgtct     4980

caacctcacc atactgcata tatcatcttt acaagtggtt ctacgggacg ccccaaggga     5040

gtaatggttg gtcagactgc gattgtaaat cgtctgttgt ggatgcaaaa ccactaccct     5100

ttgacggggg aggacgttgt agcccaaaag actccttgct cgttcgatgt ctcagtctgg     5160

gagttctttt ggccatttat agcaggggcc aaattagtta tggcggagcc ggaagcccac     5220

cgagacccac ttgcgatgca gcaattcttt gctgagtatg gtgtcaccac tacacatttc     5280

gtcccatcga tgttagcggc cttcgtggct tctcttactc cacaaacggc taggcaatct     5340

tgtgccacac taaagcaagt cttctgctcc ggcgaggcat tacctgcaga cttgtgccgg     5400

gaatggcagc aactcacagg agctccattg cacaatctat acggaccgac cgaggccgca     5460

gtagacgtat cttggtatcc tgcgtttggc gaggagttag cgcaagtaag aggttcgtca     5520

gtaccaatag gataccccgt atggaacacg gggcttcgga tactggacgc gatgatgcat     5580

ccggtcccac caggagtcgc gggcgattta tacctgactg ggatacagct ggcccaaggt     5640

tacctaggga gacctgacct tacggcgtcg aggttcatag cggatccgtt tgctccgggt     5700

gagcgcatgt accgtacggg cgacgtcgcg cgatggctag ataatggcgc cgtagagtat     5760

cttggtagat cagacgatca gttaaagata cggggacaac gaatagagct tggggaaata     5820

gaccgggtaa tgcaggcttt gccagatgtc gagcaagcgg tggcttcgtg tgctattgcg     5880

cgggaggaca tacctgggaa caaacacctt gtagcgtaca tagttcctca agaggagcaa     5940

acatgcactg agcgatcgag gtccacactt acagtttcgt tcgtccggag tttccttaag     6000

gagaaactcc ccgaatatat ggtaccgagc gcaatagtga ttctagacgc tctccccctg     6060

actcctaatg gaaagctaga ccggcgggcg ttacccgccc ctgacctgca ctcacaactt     6120

gagacaatta ttgctgcggc tttctcgagc ctgctcgggt gcgacgtaca agacgcggat     6180

gctgactttt tcgcgctagg tggccattcg ctgcttgcca tgaagctagc cgctcagctt     6240

tcccgacaag tagcgcggca ggtgacacca ggccaagtta tggtagcttc gactgtcgca     6300

aagctcgcaa cgatcataga cgcggagtta gataaatacg tcgctccaag gaacccgata     6360

cctggaattg gggcgctagt tcccgctccc gtggtaatcg cagcaggccg tacggaggaa     6420

ccaattgcca tcgtttcgat ggcatgtcgt ttaccgggag gagtcaatac gccccaacgg     6480

ctctgggaat tactacggga gggtggtgaa accttgtccg ggttcccaac ggaccgtggc     6540

tgggacctag cacggcttca ccaccctgat ccggacaacc ccggaacgag ctacgttgat     6600

aagggtggat ttctcgacga cgcggcgggt ttcgacgcag agtttttcgg ggtttcacca     6660

agggaagctg ccgctatgga ccctcagcaa cgattacttt tagagacctc gtgggagcta     6720

gttgaaaatg cgggcataga tccacatagc ctgcgaggga cagcgacagg ggtgttccta     6780

ggagttgcga agtttggtta tggtgaggac acagcagcag cggaagatgt tgaaggttat     6840

tcagttaccg gtgttgctcc cgctgtggca tctggccgca tatcctacac tatgggttta     6900

gaaggtcctt ccatctcggt cgataccgca tgctcaagct cgctagtcgc gcttcatcta     6960

gccgtagagt ccctccgaaa gggtgagtca tctatggcgg tggtgggtgg tgcagccgtt     7020

atggcgactc ctggggtatt tgttgatttt tcacgccaac gggcgcttgc cgcagacggc     7080

cgttccaaag cgttcggggc aggtgcagat ggttttggtt tcagcgaggg agtcacgctg     7140

gttctactag agcgtttaag tgaggcgcgt cgtaacggtc atgaagttct agctgtagtg     7200

cgcgggtccg cgttaaacca ggacggagcg agcaacggac tttcagcacc ctccggccct     7260

gcgcaacgta gagtaataag gcaagcgctc gaatcgtgtg ggcttgaacc gggggatgtt     7320

gacgcggttg aggcgcatgg tactggtaca gcactaggtg acccaataga ggccaatgcg     7380

ctgttggaca cttacgggcg agaccgtgat gcggatcgtc cactttggtt ggggtccgtt     7440

aagagcaata ttgggcacac tcaagctgcg gccggggtta caggactgct gaaggttgtg     7500

ttagcactgc gcaatggtga gctacctgca acgttacatg tcgaggaacc aactccacac     7560

gtcgattggt cctcaggtgg tgtcgcatta ctggcgggta atcaaccatg gcgaagggga     7620

gaaaggacca gaagggcggc agtgagcgcc tttggtatct ccggtacaaa tgctcacgtg     7680

atagtggaag aggcgcctca ggaagttcga cccgcccctg gccaagggct gtcgccagcc     7740

gtgtccacgt tagttgttgc aggtaaaacc atgcagcgtg taagtgcgac agctggaatg     7800

cttgcagact ggatggaggg tcctggggcc gatgttgcat tggcggatgt ggcccatacc     7860

ctgaaccatc accgatcaag acagcccaag ttcgggacgg ttgtagcgcg tgacaggact     7920

caggcgatag ctgggctccg tgcattggcg gctggtcaac atgctcctgg ggtcgtcaac     7980

ccagctgaag gttccccagg accaggcacc gtgttcgttt ttcccggtca aggttcgcag     8040

agggcaggga tgggggagga actcgcggca gcctttcctg tcttcgctcg aatacatcag     8100

caagtttggg acctcctaga tgttcccgac ctcgacgtta atgaaaccgg gtacgcccaa     8160

ccagcgctgt tcgcgcttca ggtcgcgctc tttggccttc tggagtcgtg gggtgttagg     8220

ccagatgcag tggtagggca ctcagttggt gagctggccg cggggtacgt gtccggtctt     8280

tggtcactag aggacgcctg cacactagtc tcagcaagag cgcgcctaat gcaggcactg     8340

cctgctggag gggtgatggc ggcagtcccc gtctccgagg atgaggcgcg ggccgtcctg     8400

ggcgagggag ttgaaattgc ggctgtgaat ggaccctcgt ccgttgtgct ctcaggggac     8460

gaggcggcag tcttacaggc cgccgaaggt ctaggtaagt ggacgcgact gccgaccagc     8520

catgcttttc actcagcgag aatggaaccc atgctagaag agtttcgggc cgtagcagag     8580

ggtctgacct atcgtacccc tcaagtagct atggctgctg gggatcaggt gatgacagca     8640

gaatattggg tgcggcaggt tcgggacaca gttcgcttcg gggagcaagt agcgtcattc     8700

gaggatgcgg tgtttgttga gttaggcgct gacagaagtc tagcgcgttt ggtggacggc     8760

atcgccatgc tgcacggtga ccacgaagcg caggccgcgg accataggca aatcaccgaa     8820

gcggttgcgg atgcttacgt cttaggccac cttccggatt ttgcggcgct gcggcggcct     8880

cacgcacgaa agttggactt accaacttat cccttcgagc gtagacagta ctggttcaga     8940

gatgcgcgtg agaggccgga acaacccaga gataccggcg gacctcgcac agaagcagtc     9000

cgtctgttag aggatggtag gattgaagaa ttagctgcac ttttgggagg ggccagtgat     9060

gaccaacaca cattacaggt gctgactaag ttggcggcgc aacataacca acaacgaaca     9120

acccggtcaa tcgctgacga caggtacgaa ataaggtggg accgatcgac ttccccacta     9180

tccggagcag atgttgacca agcggggagc tggatcgtgg tgtcagatga cgcagatgcc     9240

gttcccccgc tagtggactt gctggctgca cgtaacgagc cccatcaggt tgttggtcta     9300

cccgcttcgg acgcagacga ggagaggctc gcagagactc tgcgtgcggc tgcgactgaa     9360

gatgctaccc ttcggatagt ccacgttgcg gcgctcgaag caggcgctac ccccagcatg     9420

cgttcactgc tccgcatgca gcaccgaata ctaggtggca cgcggcgggt gttcagggca     9480

gcggtcgcag cggagttaag aggtcccatt tggatagtga cgcggggagc acaaagagtg     9540

gctgacaccg atacagttgc cccgcatcag tcatgcctct ggggatttgg gagggcagca     9600

tcgctggagc tgccgcacgt ttggggtggc ctagcagatt tatcagaggg cggtgacaat     9660

gcggccgatg agtggagtgc gctagtggac cgcattgccg caccccacgg ttcagcagtt     9720

agggaggacc aactggcgct gagagacagg gccgtatata cgccaagact ggccagacgt     9780

tctgcgcccc cgagcgggac tcccctacat ctacgagggg atggcacagt gttaataaca     9840

ggtgggactg gtacactagg taggctatta gcgcgtcacc tagtaacaga gcatggggtg     9900

cggcatctct tactagtttc aaggagaggc gccgatgccc ctggctcgga tgaactgcgc     9960

gcagaaatag aggacttagg tgccagcgcg gagatcgcag cgtgtgatac agcggatcgc    10020

gatgccctat ctgccctact agatggtctc ccccggcccc ttacgggtgt cgttcacgcc    10080

gctggcgtgt tagccgatgg acttgtcact agcattgacg agcctgcggt ggaacaggtt    10140

ctccgagcaa aggtggacgc ggcatggaac ctacacgaac tcacagctaa taccgggcta    10200

tcctttttcg ttcttttctc atcagcagca tcggtcctgg caggtccagg gcaaggagtt    10260

tatgcggctg caaatgaatc gctcaacgca ctagctgcgt taaggcgaac taggggtctg    10320

ccggccaagg ctctgggatg gggcctgtgg gccatcgggc gggcaatcgc ttttgcggag    10380

cagaccgggg acgccatcgc tccagaggaa ggagcatacg cttttgaaac tctgttaagg    10440

cataaccgtg cctactcggg atatgcgccc gtcattggat ctccctggtt gaccgcgttc    10500

gcacagcatt ccccctttgc agaaaaattc caatcactcg gacagaatcg gtcagggaca    10560

tcgaaattct tagcggagct agttgacctg cctcgtgagg aatggccgga taggctcagg    10620

agactactag agttagttag gtcccatgcc gccgcggtct ccggttacgg tagtgcagat    10680

caactgccgg aaagaaaagc gttcaaggat ttggggtttg attcgctggc cgccgttgaa    10740

ctgcgtaacc ggctgggaac ggctacaggg gtacgactgc cgtcaaccct agtatttgat    10800

cacccaactc cgctggccgt cgctgagcac ttaagagata ggctaacatc cggggaagat    10860

aaccctatcc ccctatgtca aggcgatggg gaggagatga gcacatggct acgtcgtttt    10920

ggacccccag tcgaacatcg ggccaggcta gtgtgtttcc cccacgcagg cgcagcggcg    10980

gattcatact tagacctagc aagagcgtta gcaccagaga tcgatgttca tgctgttcaa    11040

taccccggca ggcaagacag aagggacgag gagccattag gaaccgcagg tgaaattgca    11100

gatgaagtgg cagcggtgct acgtgcgtcg ggaggggatg ggccttttgc acttttcggc    11160

cacagtatgg gcgccctcat cgcgtacgag acagcaaggc gattagagag ggaaccggga    11220

gggggaccct tacgtttatt cgtgagcgga caaacagcgc cacgtgtcca tgaacgaaga    11280

actgatctgc ccggtgacga tggactcgtg gacgagctta ggcgacttgg cacctccgag    11340

gcagcgctcg cagacgaagc cctgctggct atgtctctcc cggtgctcag ggcggattat    11400

agggtgttaa gatcctacgc ttgggcggat ggtcccccac tacgcgccgg tataactgcc    11460

ctctgcggtg atgcagaccc actaactgca acaggggatg cggaacgctg gttacaacat    11520

tccgtgattc cgggtcggac acggacattt cccggtgggc atttttattt aggggaacaa    11580

gtgaccgagg tggcaggggc tgtccgtaga gatttactga gagcagggtt agcgggttga    11640


<210>  32
<211>  11979
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSS

<400>  32
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgtg ccggttgagc agccatttgt gcatagccct     1560

gaagatcgct atcaaccgtt cgcgctgacc gacgtacagc aagcctacct ggtggggcgt     1620

cagccgggat ttgccctggg cggtgttggc tctcatttct tcgtcgaatt cgagattgca     1680

gatttagact tgacccgcct ggaaacggtt tggaaccgtt taatagcacg ccacgatatg     1740

ttgcgtgcta ttgtacgtga cggtcagcaa caggtgctgg aacagacccc gccatgggtg     1800

atcccggcgc atactctgca cacaccagaa gaggcattac gagttagaga aaaactggct     1860

catcaggtct taaaccctga agtctggccc gtatttgatc tgcaagtggg ctatgttgac     1920

ggtatgccgg cacgtctttg gctctgccta gataatctat tattggacgg gctgagtatg     1980

cagattcttc tcgccgaact ggagcacgga tatcgttacc ctcaacagct actgcctccc     2040

ctgccagtta cctttcgtga ttacttgcaa cagccgagcc ttcagtctcc gaacccagac     2100

agcctggcat ggtggcaggc tcaactggat gacatcccgc cagcaccggc tctcccactg     2160

cgttgtctgc cacaggaagt ggagactcct cgattcgcac ggcttaatgg cgctctcgat     2220

tcaacacgtt ggcatcgtct gaaaaagcgc gcggccgacg cgcacctgac tccgtcggcc     2280

gtgttattga gtgtttggtc cacagtcctg tcagcatggt cggctcagcc ggaatttact     2340

ttaaacttga cacttttcga tcgtcgccct ctgcatcccc agattaatca aatcttgggc     2400

gattttacct cacttatgct tctctcgtgg catccgggtg aatcctggct gcacagcgcg     2460

cagtctctgc aacagcgctt aagtcaaaac ttgaatcacc gtgatgtttc cgccattcgc     2520

gtcatgcggc agctggcgca acagcaaaat gtcccggccg tacctatgcc cgtggttttc     2580

acctctgcgc tgggctttga acaggataac ttcctggccc ggcgaaatct actgaaaccg     2640

gtatggggta ttagccagac gccgcaagtc tggctggatc atcagatcta tgaatctgag     2700

ggcgaactgc gttttaactg ggatttcgtt gcagctctgt ttccggcggg tcaggtggag     2760

cgtcagttcg aacaatactg cgcattattg aatcgcatgg ctgaggatga aagcgggtgg     2820

cagctcccgc tggcggccct ggtgcctccc gttaaacatg cgggtcagtg cgccgagcgc     2880

agcccgcgtg tttgtccaga acagtctcaa ccgcacatcg cagctgatga aagtactgtt     2940

tccctgatat gtgacgcatt tcgtgaggtc gtaggggaaa gtgtgacccc ggctgagaac     3000

tttttcgaag cgggagccac gtccttaaat ttggtacagc tgcatgtgct tctccaacgt     3060

cacgaatttt caaccctgac gctactggat ttattcacgc acccgtcgcc agcggccctt     3120

gcggactatc tcgcgggtgt cgccaccgta gaaaaaacga agaggcctcg gcccgtgaga     3180

aggcgtcagc gccggatcca gcacttgccc ttagtagctg cgcaacctgg aatatggatg     3240

gccgagaagt tatctgaact accatcagcg tggagcgtag cgcattacgt ggagctcact     3300

ggtgaggttg actcgcctct tttggccagg gcggtagtgg ctggccttgc acaagctgac     3360

accttaagaa tgcgtttcac agaggataat ggggaagttt ggcaatgggt agacgatgcg     3420

ttaacatttg agttaccgga aatcatagac ctgcgcacta acatagaccc tcacgggaca     3480

gctcaggcct tgatgcaagc ggacctgcaa caggacctac gtgtggattc ggggaagcct     3540

ctggtcttcc atcagctaat tcaagtagcg gacaatcgct ggtactggta tcaaaggtac     3600

caccacttgc ttgtggacgg gttcagtttt ccagcgataa ccaggcaaat agccaacatt     3660

tattgcactt ggttgcgagg agagcctacg cccgcatccc ccttcacgcc attcgcagac     3720

gttgttgagg aataccaaca gtatcgcgag agcgaagcgt ggcaacgcga tgcggcattc     3780

tgggcggagc aacgacggca actaccgcct cccgcatccc tatcacctgc cccgctcccc     3840

ggccggtccg cgtcagccga cattctacgg ctaaagctgg agttcacaga tggtgaattt     3900

cgacagcttg ctacacaact cagcggggta caaaggacag acctagcgct cgctctggct     3960

gcattatggc taggacgact ttgcaatcga atggactacg cggcgggttt catatttatg     4020

cgccggctcg gcagcgcagc gttgaccgca acgggtccag ttttaaatgt tcttcctttg     4080

ggaatccaca taggcaaccc aagcttctct gagcttctca ccagggttcg cgaggtcgcc     4140

ttaggcgcgt atgcacacca acatattcct tttgagatgt tagtagaggc actgcaacca     4200

gagcgaaacc ttagccatac tcctctcttc caagtgatgt ttgtccttca gaatgcgccc     4260

gcgtcccaat tagagttaac cgggatcacc gcaaacccaa ttaaggttaa atcaactacc     4320

acgaagttcg acctaacttt aatcatgcaa aacacagcta gcggattagt aggtgtttgg     4380

gagtacaaca cggatttatt cgacgcgtca acgattgagc gaatgacagg gcactttgta     4440

accctcctcg agggcgttat cgccaatcca caacagccga tctctcaact tcctatttta     4500

actacagtgg agcaacagca acttttagtc gagtggaata acacgcaaac cgactacccc     4560

gctgataagt gtatacatca attattcgag gaacaggtcg agcgcacacc agacgccgtt     4620

gctgtcgtct ttgggaatca gcaactcagc tatcgagaga tgcgcgaaca agtggttgca     4680

ctcgccaatt tattacgtga gcggggagtc aagccaggag actccgttgc cgtggcctta     4740

ccacgctctg ttttcttaac ccttgcacta cacgcgattg tcgaggcagg tgccgcctgg     4800

ctacctcttg acacaggata tcctgacgat agattaaaaa tgatgctcga ggatgcacgg     4860

ccttcccttc tgatcacaac agacgatcaa ttaccccgct tcagtgacgt acctaatctg     4920

acctcactct gttacaacgc tcccttgacg cctcaaggga gcgccccttt acagctgtct     4980

caacctcacc atactgcata tatcatcttt acaagtggtt ctacgggacg ccccaaggga     5040

gtaatggttg gtcagactgc gattgtaaat cgtctgttgt ggatgcaaaa ccactaccct     5100

ttgacggggg aggacgttgt agcccaaaag actccttgct cgttcgatgt ctcagtctgg     5160

gagttctttt ggccatttat agcaggggcc aaattagtta tggcggagcc ggaagcccac     5220

cgagacccac ttgcgatgca gcaattcttt gctgagtatg gtgtcaccac tacacatttc     5280

gtcccatcga tgttagcggc cttcgtggct tctcttactc cacaaacggc taggcaatct     5340

tgtgccacac taaagcaagt cttctgctcc ggcgaggcat tacctgcaga cttgtgccgg     5400

gaatggcagc aactcacagg agctccattg cacaatctat acggaccgac cgaggccgca     5460

gtagacgtat cttggtatcc tgcgtttggc gaggagttag cgcaagtaag aggttcgtca     5520

gtaccaatag gataccccgt atggaacacg gggcttcgga tactggacgc gatgatgcat     5580

ccggtcccac caggagtcgc gggcgattta tacctgactg ggatacagct ggcccaaggt     5640

tacctaggga gacctgacct tacggcgtcg aggttcatag cggatccgtt tgctccgggt     5700

gagcgcatgt accgtacggg cgacgtcgcg cgatggctag ataatggcgc cgtagagtat     5760

cttggtagat cagacgatca gttaaagata cggggacaac gaatagagct tggggaaata     5820

gaccgggtaa tgcaggcttt gccagatgtc gagcaagcgg tggcttcgtg tgctattgcg     5880

cgggaggaca tacctgggaa caaacacctt gtagcgtaca tagttcctca agaggagcaa     5940

acatgcactg agcgatcgag gtccacactt acagtttcgt tcgtccggag tttccttaag     6000

gagaaactcc ccgaatatat ggtaccgagc gcaatagtga ttctagacgc tctccccctg     6060

actcctaatg gaaagctaga ccggcgggcg ttacccgccc ctgacctgca ctcacaactt     6120

gagacaatta ttgctgcggc tttctcgagc ctgctcgggt gcgacgtaca agacgcggat     6180

gctgactttt tcgcgctagg tggccattcg ctgcttgcca tgaagctagc cgctcagctt     6240

tcccgacaag tagcgcggca ggtgacacca ggccaagtta tggtagcttc gactgtcgca     6300

aagctcgcaa cgatcataga cgcggagtta gataaatacg tcgctccaag gaacccgata     6360

ctgccagtag aacagccttt tgtgcactca ccggaagagc ggtatcgacc attcgcgtta     6420

acggatgttc agcaagccta cctggtcggg cgccagccgg gatttgccct gggcggtgta     6480

ggctcgcatt tcttcgtgga attcgagatc gcagatctcg acatacaccg cctggaaaaa     6540

gtgtggaacc gtttaattgc acgtcatgat atgttgcgcg ctgtggttcg tgacggtcag     6600

caacgtgtac tggaacagac cccgccatgg gtcataccag cacatattct tcacagtcct     6660

gaagaggcat tacaggttcg tgatcgttta gctcaccaag tgttgaaccc cgaagtctgg     6720

ccggtatttg atctgcaggt gggcttcgtt gacggtatgc cggcccgttt atggttgtgc     6780

cttgataacc tgttattgga cgggctgagc atgcagattc ttctctctga actggagcat     6840

ggatatcgct acccacagca actccctccc ccgttgccga tcacttttcg cgattatctt     6900

cagcaaccgg cactccgtac cccaaatcct gactcattgg cttggtggca gacgcaactg     6960

gatgacatcc cacctgcgcc cgccctcccg ctacgttgtc tgcctcaaga tgttgaaacc     7020

ccgcgtttcg cgcgtctgta cggcgcaatg gattctgctc gttggcgtcg cctgaaacag     7080

cgtgcggccg acgcacatct gactccgtca gctgtcctac tgagcgtatg gtctacagtg     7140

ctggcagctt ggtcggcgca gccggatttt actctcaacc tgacattatt cgaccggcga     7200

ccactgcacc ctcagattaa tcaaatcctt ggcgatttta cctcactgat gttattgtcg     7260

tggcatccgg gtgagagttg gctgcagtcc gcgcgtcttc tccagcaacg cctttcagaa     7320

tcgctcaacc accgtgatgt tagcgccatt cgcgtcatgc ggcagctggc gagaaggcaa     7380

aatgtcccgg ccgtacccat gccggtcgta tttacctctg cgctggggtt tgaacaggat     7440

aacttcctgg cccgtcgcaa tctactgaaa ccggtgtggg gtatcagtca gacgccgcaa     7500

gtttggctgg accatcaggt ctatgaatcc gagggcgaac tgcgttttaa ctgggatttc     7560

gttgcggccc tgtttccgga cggtcaagtg gaacgtcagt tcgcgcaata ctgcgcctta     7620

ttgaatcgca tggcagaaga tgacagctct tggcagttgc cgcttgctga tctggtgccc     7680

ccgttaaaag tgaccgagcg gcgagcgaga aggctgcgtc cagaacgcgc ccagcctcgt     7740

attgcagctg ataagagttc cgttagtctg atctgtgaca cttttcgtga ggtggttggg     7800

gaacccgtgg caccggctga gaactttttc gaagcgggag ccacatccct caatctggtt     7860

cagctgcatg tccttctcca acgtcacgaa tttgcgacct taacgctact ggatttgttc     7920

acccatccaa gccctgttgc attggctaac tatcttgcgg gtgtggccct ggaagagaaa     7980

acgaagcgcg tgcggccggt tcggcgaaga cagcgtcgca ttcagcactt gcccttagta     8040

gctgcgcaac ctggaatatg gatggccgag aagttatctg aactaccatc agcgtggagc     8100

gtagcgcatt acgtggagct cactggtgag gttgactcgc ctcttttggc cagggcggta     8160

gtggctggcc ttgcacaagc tgacacctta agaatgcgtt tcacagagga taatggggaa     8220

gtttggcaat gggtagacga tgcgttaaca tttgagttac cggaaatcat agacctgcgc     8280

actaacatag accctcacgg gacagctcag gccttgatgc aagcggacct gcaacaggac     8340

ctacgtgtgg attcggggaa gcctctggtc ttccatcagc taattcaagt agcggacaat     8400

cgctggtact ggtatcaaag gtaccaccac ttgcttgtgg acgggttcag ttttccagcg     8460

ataaccaggc aaatagccaa catttattgc acttggttgc gaggagagcc tacgcccgca     8520

tcccccttca cgccattcgc agacgttgtt gaggaatacc aacagtatcg cgagagcgaa     8580

gcgtggcaac gcgatgcggc attctgggcg gagcaacgac ggcaactacc gcctcccgca     8640

tccctatcac ctgccccgct ccccggccgg tccgcgtcag ccgacattct acggctaaag     8700

ctggagttca cagatggtga atttcgacag cttgctacac aactcagcgg ggtacaaagg     8760

acagacctag cgctcgctct ggctgcatta tggctaggac gactttgcaa tcgaatggac     8820

tacgcggcgg gtttcatatt tatgcgccgg ctcggcagcg cagcgttgac cgcaacgggt     8880

ccagttttaa atgttcttcc tttgggaatc cacataggca acccaagctt ctctgagctt     8940

ctcaccaggg ttcgcgaggt cgccttaggc gcgtatgcac accaacatat tccttttgag     9000

atgttagtag aggcactgca accagagcga aaccttagcc atactcctct cttccaagtg     9060

atgtttgtcc ttcagaatgc gcccgcgtcc caattagagt taaccgggat caccgcaaac     9120

ccaattaagg ttaaatcaac taccacgaag ttcgacctaa ctttaatcat gcaaaacaca     9180

gctagcggat tagtaggtgt ttgggagtac aacacggatt tattcgacgc gtcaacgatt     9240

gagcgaatga cagggcactt tgtaaccctc ctcgagggcg ttatcgccaa tccacaacag     9300

ccgatctctc aacttcctat tttaactaca gtggagcaac agcaactttt agtcgagtgg     9360

aataacacgc aaaccgacta ccccgctgat aagtgtatac atcaattatt cgaggaacag     9420

gtcgagcgca caccagacgc cgttgctgtc gtctttggga atcagcaact cagctatcga     9480

gagatgcgcg aacaagtggt tgcactcgcc aatttattac gtgagcgggg agtcaagcca     9540

ggagactccg ttgccgtggc cttaccacgc tctgttttct taacccttgc actacacgcg     9600

attgtcgagg caggtgccgc ctggctacct cttgacacag gatatcctga cgatagatta     9660

aaaatgatgc tcgaggatgc acggccttcc cttctgatca caacagacga tcaattaccc     9720

cgcttcagtg acgtacctaa tctgacctca ctctgttaca acgctccctt gacgcctcaa     9780

gggagcgccc ctttacagct gtctcaacct caccatactg catatatcat ctttacaagt     9840

ggttctacgg gacgccccaa gggagtaatg gttggtcaga ctgcgattgt aaatcgtctg     9900

ttgtggatgc aaaaccacta ccctttgacg ggggaggacg ttgtagccca aaagactcct     9960

tgctcgttcg atgtctcagt ctgggagttc ttttggccat ttatagcagg ggccaaatta    10020

gttatggcgg agccggaagc ccaccgagac ccacttgcga tgcagcaatt ctttgctgag    10080

tatggtgtca ccactacaca tttcgtccca tcgatgttag cggccttcgt ggcttctctt    10140

actccacaaa cggctaggca atcttgtgcc acactaaagc aagtcttctg ctccggcgag    10200

gcattacctg cagacttgtg ccgggaatgg cagcaactca caggagctcc attgcacaat    10260

ctatacggac cgaccgaggc cgcagtagac gtatcttggt atcctgcgtt tggcgaggag    10320

ttagcgcaag taagaggttc gtcagtacca ataggatacc ccgtatggaa cacggggctt    10380

cggatactgg acgcgatgat gcatccggtc ccaccaggag tcgcgggcga tttatacctg    10440

actgggatac agctggccca aggttaccta gggagacctg accttacggc gtcgaggttc    10500

atagcggatc cgtttgctcc gggtgagcgc atgtaccgta cgggcgacgt cgcgcgatgg    10560

ctagataatg gcgccgtaga gtatcttggt agatcagacg atcagttaaa gatacgggga    10620

caacgaatag agcttgggga aatagaccgg gtaatgcagg ctttgccaga tgtcgagcaa    10680

gcggtggctt cgtgtgctat tgcgcgggag gacatacctg ggaacaaaca ccttgtagcg    10740

tacatagttc ctcaagagga gcaaacatgc actgagcgat cgaggtccac acttacagtt    10800

tcgttcgtcc ggagtttcct taaggagaaa ctccccgaat atatggtacc gagcgcaata    10860

gtgattctag acgctctccc cctgactcct aatggaaagc tagaccggcg ggcgttaccc    10920

gcccctgacc tgcactcaca acttgagaca attattgctg cggctttctc gagcctgctc    10980

gggtgcgacg tacaagacgc ggatgctgac tttttcgcgc taggtggcca ttcgctgctt    11040

gccatgaagc tagccgctca gctttcccga caagtagcgc ggcaggtgac accaggccaa    11100

gttatggtag cttcgactgt cgcaaagctc gcaacgatca tagacgcgga gttagataaa    11160

tacgtcgctc caaggaaccc gataacatcc ggggaagata accctatccc cctatgtcaa    11220

ggcgatgggg aggagatgag cacatggcta cgtcgttttg gacccccagt cgaacatcgg    11280

gccaggctag tgtgtttccc ccacgcaggc gcagcggcgg attcatactt agacctagca    11340

agagcgttag caccagagat cgatgttcat gctgttcaat accccggcag gcaagacaga    11400

agggacgagg agccattagg aaccgcaggt gaaattgcag atgaagtggc agcggtgcta    11460

cgtgcgtcgg gaggggatgg gccttttgca cttttcggcc acagtatggg cgccctcatc    11520

gcgtacgaga cagcaaggcg attagagagg gaaccgggag ggggaccctt acgtttattc    11580

gtgagcggac aaacagcgcc acgtgtccat gaacgaagaa ctgatctgcc cggtgacgat    11640

ggactcgtgg acgagcttag gcgacttggc acctccgagg cagcgctcgc agacgaagcc    11700

ctgctggcta tgtctctccc ggtgctcagg gcggattata gggtgttaag atcctacgct    11760

tgggcggatg gtcccccact acgcgccggt ataactgccc tctgcggtga tgcagaccca    11820

ctaactgcaa caggggatgc ggaacgctgg ttacaacatt ccgtgattcc gggtcggaca    11880

cggacatttc ccggtgggca tttttattta ggggaacaag tgaccgaggt ggcaggggct    11940

gtccgtagag atttactgag agcagggtta gcgggttga                           11979


<210>  33
<211>  4090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICC

<400>  33

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gly Glu Pro 
    1160                 1165                 1170             


Phe Pro  Leu Ala Pro Met Gln  His Ala Met Trp Val  Gly Arg His 
    1175                 1180                 1185             


Asp His  Gln Gln Leu Gly Gly  Val Ala Gly His Leu  Tyr Val Glu 
    1190                 1195                 1200             


Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg Leu Arg  Ala Ala Ala 
    1205                 1210                 1215             


Thr Arg  Leu Ala Leu Arg His  Pro Met Leu Arg Val  Gln Phe Leu 
    1220                 1225                 1230             


Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala Ala Gly  Ser Arg Asp 
    1235                 1240                 1245             


Phe Pro  Ile Ser Val Ala Asp  Leu Arg His Val Ala  Pro Asp Val 
    1250                 1255                 1260             


Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp Ala Lys  Ser His Gln 
    1265                 1270                 1275             


Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala Leu Thr  Leu Leu Pro 
    1280                 1285                 1290             


Gly Glu  Arg Thr Arg Leu His  Val Asp Leu Asp Met  Gln Ala Ala 
    1295                 1300                 1305             


Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala Asp Leu  Ala Ala Leu 
    1310                 1315                 1320             


Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly Tyr Thr  Tyr Arg Glu 
    1325                 1330                 1335             


Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr Leu Pro  Gln Pro Val 
    1340                 1345                 1350             


Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln Arg Ile  Pro Gln Leu 
    1355                 1360                 1365             


Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala Gly Gly  Glu Arg Asp 
    1370                 1375                 1380             


Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp Leu Asp  Pro Gln Thr 
    1385                 1390                 1395             


Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala Arg Gly  Ile Thr Pro 
    1400                 1405                 1410             


Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn Val Leu  Ala Arg Trp 
    1415                 1420                 1425             


Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu Pro Leu  Phe Ser Arg 
    1430                 1435                 1440             


Gln Ala  Leu His Pro Asp Val  Asp Leu Leu Val Gly  Asp Phe Thr 
    1445                 1450                 1455             


Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly Asp Thr  Val Ser Asn 
    1460                 1465                 1470             


Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr Glu Asp  Trp Glu His 
    1475                 1480                 1485             


Arg His  Trp Ser Gly Val Glu  Leu Leu Arg Glu Leu  Lys Arg Gln 
    1490                 1495                 1500             


Gln Arg  Tyr Pro His Gly Ala  Pro Val Val Phe Thr  Ser Asn Leu 
    1505                 1510                 1515             


Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu Ser Pro  Leu Gly Glu 
    1520                 1525                 1530             


Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln Val Trp  Ile Asp His 
    1535                 1540                 1545             


Leu Ala  Phe Glu His His Gly  Glu Val Trp Leu Gln  Trp Asp Ser 
    1550                 1555                 1560             


Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val Glu Thr  Leu Phe Asp 
    1565                 1570                 1575             


Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys Asp Asp  Glu Ser Ala 
    1580                 1585                 1590             


Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro Ala Ser  Gln Arg Ala 
    1595                 1600                 1605             


Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala Pro Ile  Pro Glu Gly 
    1610                 1615                 1620             


Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala Leu Gln  Gln Pro Gln 
    1625                 1630                 1635             


Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln Trp Asn  Ser Tyr Arg 
    1640                 1645                 1650             


Glu Met  Arg Glu Gln Val Val  Ala Leu Ala Asn Leu  Leu Arg Glu 
    1655                 1660                 1665             


Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala Val Ala  Leu Pro Arg 
    1670                 1675                 1680             


Ser Val  Phe Leu Thr Leu Ala  Leu His Ala Ile Val  Glu Ala Gly 
    1685                 1690                 1695             


Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr Pro Asp  Asp Arg Leu 
    1700                 1705                 1710             


Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser Leu Leu  Ile Thr Thr 
    1715                 1720                 1725             


Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val Pro Asn  Leu Thr Ser 
    1730                 1735                 1740             


Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln Gly Ser  Ala Pro Leu 
    1745                 1750                 1755             


Gln Leu  Ser Gln Pro His His  Thr Ala Tyr Ile Ile  Phe Thr Ser 
    1760                 1765                 1770             


Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met Val Gly  Gln Thr Ala 
    1775                 1780                 1785             


Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn His Tyr  Pro Leu Thr 
    1790                 1795                 1800             


Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro Cys Ser  Phe Asp Val 
    1805                 1810                 1815             


Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile Ala Gly  Ala Lys Leu 
    1820                 1825                 1830             


Val Met  Ala Glu Pro Glu Ala  His Arg Asp Pro Leu  Ala Met Gln 
    1835                 1840                 1845             


Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr Thr His  Phe Val Pro 
    1850                 1855                 1860             


Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu Thr Pro  Gln Thr Ala 
    1865                 1870                 1875             


Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val Phe Cys  Ser Gly Glu 
    1880                 1885                 1890             


Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp Gln Gln  Leu Thr Gly 
    1895                 1900                 1905             


Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr Glu Ala  Ala Val Asp 
    1910                 1915                 1920             


Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu Leu Ala  Gln Val Arg 
    1925                 1930                 1935             


Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val Trp Asn  Thr Gly Leu 
    1940                 1945                 1950             


Arg Ile  Leu Asp Ala Met Met  His Pro Val Pro Pro  Gly Val Ala 
    1955                 1960                 1965             


Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu Ala Gln  Gly Tyr Leu 
    1970                 1975                 1980             


Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe Ile Ala  Asp Pro Phe 
    1985                 1990                 1995             


Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly Asp Val  Ala Arg Trp 
    2000                 2005                 2010             


Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly Arg Ser  Asp Asp Gln 
    2015                 2020                 2025             


Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu Gly Glu  Ile Asp Arg 
    2030                 2035                 2040             


Val Met  Gln Ala Leu Pro Asp  Val Glu Gln Ala Val  Ala Ser Cys 
    2045                 2050                 2055             


Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn Lys His  Leu Val Ala 
    2060                 2065                 2070             


Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys Thr Glu  Arg Ser Arg 
    2075                 2080                 2085             


Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser Phe Leu  Lys Glu Lys 
    2090                 2095                 2100             


Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile Val Ile  Leu Asp Ala 
    2105                 2110                 2115             


Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp Arg Arg  Ala Leu Pro 
    2120                 2125                 2130             


Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp Lys Tyr  Val Ala Pro 
    2135                 2140                 2145             


Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu 
    2150                 2155                 2160             


Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu 
    2165                 2170                 2175             


Gly Gly  His Ser Leu Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser 
    2180                 2185                 2190             


Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly Gln Val  Met Val Ala 
    2195                 2200                 2205             


Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Pro 
    2210                 2215                 2220             


Val Glu  Gln Pro Phe Val His  Ser Pro Glu Glu Arg  Tyr Arg Pro 
    2225                 2230                 2235             


Phe Ala  Leu Thr Asp Val Gln  Gln Ala Tyr Leu Val  Gly Arg Gln 
    2240                 2245                 2250             


Pro Gly  Phe Ala Leu Gly Gly  Val Gly Ser His Phe  Phe Val Glu 
    2255                 2260                 2265             


Phe Glu  Ile Ala Asp Leu Asp  Ile His Arg Leu Glu  Lys Val Trp 
    2270                 2275                 2280             


Asn Arg  Leu Ile Ala Arg His  Asp Met Leu Arg Ala  Val Val Arg 
    2285                 2290                 2295             


Asp Gly  Gln Gln Arg Val Leu  Glu Gln Thr Pro Pro  Trp Val Ile 
    2300                 2305                 2310             


Pro Ala  His Ile Leu His Ser  Pro Glu Glu Ala Leu  Gln Val Arg 
    2315                 2320                 2325             


Asp Arg  Leu Ala His Gln Val  Leu Asn Pro Glu Val  Trp Pro Val 
    2330                 2335                 2340             


Phe Asp  Leu Gln Val Gly Phe  Val Asp Gly Met Pro  Ala Arg Leu 
    2345                 2350                 2355             


Trp Leu  Cys Leu Asp Asn Leu  Leu Leu Asp Gly Leu  Ser Met Gln 
    2360                 2365                 2370             


Ile Leu  Leu Ser Glu Leu Glu  His Gly Tyr Arg Tyr  Pro Gln Gln 
    2375                 2380                 2385             


Leu Pro  Pro Pro Leu Pro Ile  Thr Phe Arg Asp Tyr  Leu Gln Gln 
    2390                 2395                 2400             


Pro Ala  Leu Arg Thr Pro Asn  Pro Asp Ser Leu Ala  Trp Trp Gln 
    2405                 2410                 2415             


Thr Gln  Leu Asp Asp Ile Pro  Pro Ala Pro Ala Leu  Pro Leu Arg 
    2420                 2425                 2430             


Cys Leu  Pro Gln Asp Val Glu  Thr Pro Arg Phe Ala  Arg Leu Tyr 
    2435                 2440                 2445             


Gly Ala  Met Asp Ser Ala Arg  Trp Arg Arg Leu Lys  Gln Arg Ala 
    2450                 2455                 2460             


Ala Asp  Ala His Leu Thr Pro  Ser Ala Val Leu Leu  Ser Val Trp 
    2465                 2470                 2475             


Ser Thr  Val Leu Ala Ala Trp  Ser Ala Gln Pro Asp  Phe Thr Leu 
    2480                 2485                 2490             


Asn Leu  Thr Leu Phe Asp Arg  Arg Pro Leu His Pro  Gln Ile Asn 
    2495                 2500                 2505             


Gln Ile  Leu Gly Asp Phe Thr  Ser Leu Met Leu Leu  Ser Trp His 
    2510                 2515                 2520             


Pro Gly  Glu Ser Trp Leu Gln  Ser Ala Arg Leu Leu  Gln Gln Arg 
    2525                 2530                 2535             


Leu Ser  Glu Ser Leu Asn His  Arg Asp Val Ser Ala  Ile Arg Val 
    2540                 2545                 2550             


Met Arg  Gln Leu Ala Arg Arg  Gln Asn Val Pro Ala  Val Pro Met 
    2555                 2560                 2565             


Pro Val  Val Phe Thr Ser Ala  Leu Gly Phe Glu Gln  Asp Asn Phe 
    2570                 2575                 2580             


Leu Ala  Arg Arg Asn Leu Leu  Lys Pro Val Trp Gly  Ile Ser Gln 
    2585                 2590                 2595             


Thr Pro  Gln Val Trp Leu Asp  His Gln Val Tyr Glu  Ser Glu Gly 
    2600                 2605                 2610             


Glu Leu  Arg Phe Asn Trp Asp  Phe Val Ala Ala Leu  Phe Pro Asp 
    2615                 2620                 2625             


Gly Gln  Val Glu Arg Gln Phe  Ala Gln Tyr Cys Ala  Leu Leu Asn 
    2630                 2635                 2640             


Arg Met  Ala Glu Asp Asp Ser  Ser Trp Gln Leu Pro  Leu Ala Asp 
    2645                 2650                 2655             


Leu Val  Pro Pro Leu Lys Val  Thr Glu Arg Arg Ala  Arg Arg Leu 
    2660                 2665                 2670             


Arg Pro  Glu Arg Ala Gln Pro  Arg Ile Ala Ala Asp  Lys Ser Ser 
    2675                 2680                 2685             


Val Ser  Leu Ile Cys Asp Thr  Phe Arg Glu Val Val  Gly Glu Pro 
    2690                 2695                 2700             


Val Ala  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    2705                 2710                 2715             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ala 
    2720                 2725                 2730             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Val Ala 
    2735                 2740                 2745             


Leu Ala  Asn Tyr Leu Ala Gly  Val Ala Leu Glu Glu  Lys Thr Lys 
    2750                 2755                 2760             


Arg Val  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gly Glu Pro 
    2765                 2770                 2775             


Phe Pro  Leu Ala Pro Met Gln  His Ala Met Trp Val  Gly Arg His 
    2780                 2785                 2790             


Asp His  Gln Gln Leu Gly Gly  Val Ala Gly His Leu  Tyr Val Glu 
    2795                 2800                 2805             


Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg Leu Arg  Ala Ala Ala 
    2810                 2815                 2820             


Thr Arg  Leu Ala Leu Arg His  Pro Met Leu Arg Val  Gln Phe Leu 
    2825                 2830                 2835             


Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala Ala Gly  Ser Arg Asp 
    2840                 2845                 2850             


Phe Pro  Ile Ser Val Ala Asp  Leu Arg His Val Ala  Pro Asp Val 
    2855                 2860                 2865             


Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp Ala Lys  Ser His Gln 
    2870                 2875                 2880             


Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala Leu Thr  Leu Leu Pro 
    2885                 2890                 2895             


Gly Glu  Arg Thr Arg Leu His  Val Asp Leu Asp Met  Gln Ala Ala 
    2900                 2905                 2910             


Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala Asp Leu  Ala Ala Leu 
    2915                 2920                 2925             


Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly Tyr Thr  Tyr Arg Glu 
    2930                 2935                 2940             


Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr Leu Pro  Gln Pro Val 
    2945                 2950                 2955             


Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln Arg Ile  Pro Gln Leu 
    2960                 2965                 2970             


Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala Gly Gly  Glu Arg Asp 
    2975                 2980                 2985             


Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp Leu Asp  Pro Gln Thr 
    2990                 2995                 3000             


Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala Arg Gly  Ile Thr Pro 
    3005                 3010                 3015             


Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn Val Leu  Ala Arg Trp 
    3020                 3025                 3030             


Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu Pro Leu  Phe Ser Arg 
    3035                 3040                 3045             


Gln Ala  Leu His Pro Asp Val  Asp Leu Leu Val Gly  Asp Phe Thr 
    3050                 3055                 3060             


Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly Asp Thr  Val Ser Asn 
    3065                 3070                 3075             


Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr Glu Asp  Trp Glu His 
    3080                 3085                 3090             


Arg His  Trp Ser Gly Val Glu  Leu Leu Arg Glu Leu  Lys Arg Gln 
    3095                 3100                 3105             


Gln Arg  Tyr Pro His Gly Ala  Pro Val Val Phe Thr  Ser Asn Leu 
    3110                 3115                 3120             


Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu Ser Pro  Leu Gly Glu 
    3125                 3130                 3135             


Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln Val Trp  Ile Asp His 
    3140                 3145                 3150             


Leu Ala  Phe Glu His His Gly  Glu Val Trp Leu Gln  Trp Asp Ser 
    3155                 3160                 3165             


Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val Glu Thr  Leu Phe Asp 
    3170                 3175                 3180             


Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys Asp Asp  Glu Ser Ala 
    3185                 3190                 3195             


Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro Ala Ser  Gln Arg Ala 
    3200                 3205                 3210             


Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala Pro Ile  Pro Glu Gly 
    3215                 3220                 3225             


Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala Leu Gln  Gln Pro Gln 
    3230                 3235                 3240             


Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln Trp Asn  Ser Tyr Arg 
    3245                 3250                 3255             


Glu Met  Arg Glu Gln Val Val  Ala Leu Ala Asn Leu  Leu Arg Glu 
    3260                 3265                 3270             


Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala Val Ala  Leu Pro Arg 
    3275                 3280                 3285             


Ser Val  Phe Leu Thr Leu Ala  Leu His Ala Ile Val  Glu Ala Gly 
    3290                 3295                 3300             


Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr Pro Asp  Asp Arg Leu 
    3305                 3310                 3315             


Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser Leu Leu  Ile Thr Thr 
    3320                 3325                 3330             


Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val Pro Asn  Leu Thr Ser 
    3335                 3340                 3345             


Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln Gly Ser  Ala Pro Leu 
    3350                 3355                 3360             


Gln Leu  Ser Gln Pro His His  Thr Ala Tyr Ile Ile  Phe Thr Ser 
    3365                 3370                 3375             


Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met Val Gly  Gln Thr Ala 
    3380                 3385                 3390             


Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn His Tyr  Pro Leu Thr 
    3395                 3400                 3405             


Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro Cys Ser  Phe Asp Val 
    3410                 3415                 3420             


Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile Ala Gly  Ala Lys Leu 
    3425                 3430                 3435             


Val Met  Ala Glu Pro Glu Ala  His Arg Asp Pro Leu  Ala Met Gln 
    3440                 3445                 3450             


Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr Thr His  Phe Val Pro 
    3455                 3460                 3465             


Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu Thr Pro  Gln Thr Ala 
    3470                 3475                 3480             


Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val Phe Cys  Ser Gly Glu 
    3485                 3490                 3495             


Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp Gln Gln  Leu Thr Gly 
    3500                 3505                 3510             


Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr Glu Ala  Ala Val Asp 
    3515                 3520                 3525             


Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu Leu Ala  Gln Val Arg 
    3530                 3535                 3540             


Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val Trp Asn  Thr Gly Leu 
    3545                 3550                 3555             


Arg Ile  Leu Asp Ala Met Met  His Pro Val Pro Pro  Gly Val Ala 
    3560                 3565                 3570             


Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu Ala Gln  Gly Tyr Leu 
    3575                 3580                 3585             


Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe Ile Ala  Asp Pro Phe 
    3590                 3595                 3600             


Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly Asp Val  Ala Arg Trp 
    3605                 3610                 3615             


Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly Arg Ser  Asp Asp Gln 
    3620                 3625                 3630             


Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu Gly Glu  Ile Asp Arg 
    3635                 3640                 3645             


Val Met  Gln Ala Leu Pro Asp  Val Glu Gln Ala Val  Ala Ser Cys 
    3650                 3655                 3660             


Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn Lys His  Leu Val Ala 
    3665                 3670                 3675             


Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys Thr Glu  Arg Ser Arg 
    3680                 3685                 3690             


Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser Phe Leu  Lys Glu Lys 
    3695                 3700                 3705             


Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile Val Ile  Leu Asp Ala 
    3710                 3715                 3720             


Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp Arg Arg  Ala Leu Pro 
    3725                 3730                 3735             


Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp Lys Tyr  Val Ala Pro 
    3740                 3745                 3750             


Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu 
    3755                 3760                 3765             


Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu 
    3770                 3775                 3780             


Gly Gly  His Ser Leu Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser 
    3785                 3790                 3795             


Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly Gln Val  Met Val Ala 
    3800                 3805                 3810             


Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile Asp Ala  Glu Thr Ser 
    3815                 3820                 3825             


Gly Glu  Asp Asn Pro Ile Pro  Leu Cys Gln Gly Asp  Gly Glu Glu 
    3830                 3835                 3840             


Met Ser  Thr Trp Leu Arg Arg  Phe Gly Pro Pro Val  Glu His Arg 
    3845                 3850                 3855             


Ala Arg  Leu Val Cys Phe Pro  His Ala Gly Ala Ala  Ala Asp Ser 
    3860                 3865                 3870             


Tyr Leu  Asp Leu Ala Arg Ala  Leu Ala Pro Glu Ile  Asp Val His 
    3875                 3880                 3885             


Ala Val  Gln Tyr Pro Gly Arg  Gln Asp Arg Arg Asp  Glu Glu Pro 
    3890                 3895                 3900             


Leu Gly  Thr Ala Gly Glu Ile  Ala Asp Glu Val Ala  Ala Val Leu 
    3905                 3910                 3915             


Arg Ala  Ser Gly Gly Asp Gly  Pro Phe Ala Leu Phe  Gly His Ser 
    3920                 3925                 3930             


Met Gly  Ala Leu Ile Ala Tyr  Glu Thr Ala Arg Arg  Leu Glu Arg 
    3935                 3940                 3945             


Glu Pro  Gly Gly Gly Pro Leu  Arg Leu Phe Val Ser  Gly Gln Thr 
    3950                 3955                 3960             


Ala Pro  Arg Val His Glu Arg  Arg Thr Asp Leu Pro  Gly Asp Asp 
    3965                 3970                 3975             


Gly Leu  Val Asp Glu Leu Arg  Arg Leu Gly Thr Ser  Glu Ala Ala 
    3980                 3985                 3990             


Leu Ala  Asp Glu Ala Leu Leu  Ala Met Ser Leu Pro  Val Leu Arg 
    3995                 4000                 4005             


Ala Asp  Tyr Arg Val Leu Arg  Ser Tyr Ala Trp Ala  Asp Gly Pro 
    4010                 4015                 4020             


Pro Leu  Arg Ala Gly Ile Thr  Ala Leu Cys Gly Asp  Ala Asp Pro 
    4025                 4030                 4035             


Leu Thr  Ala Thr Gly Asp Ala  Glu Arg Trp Leu Gln  His Ser Val 
    4040                 4045                 4050             


Ile Pro  Gly Arg Thr Arg Thr  Phe Pro Gly Gly His  Phe Tyr Leu 
    4055                 4060                 4065             


Gly Glu  Gln Val Thr Glu Val  Ala Gly Ala Val Arg  Arg Asp Leu 
    4070                 4075                 4080             


Leu Arg  Ala Gly Leu Ala Gly  
    4085                 4090 


<210>  34
<211>  4531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICH

<400>  34

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gly Glu Pro 
    1160                 1165                 1170             


Phe Pro  Leu Ala Pro Met Gln  His Ala Met Trp Val  Gly Arg His 
    1175                 1180                 1185             


Asp His  Gln Gln Leu Gly Gly  Val Ala Gly His Leu  Tyr Val Glu 
    1190                 1195                 1200             


Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg Leu Arg  Ala Ala Ala 
    1205                 1210                 1215             


Thr Arg  Leu Ala Leu Arg His  Pro Met Leu Arg Val  Gln Phe Leu 
    1220                 1225                 1230             


Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala Ala Gly  Ser Arg Asp 
    1235                 1240                 1245             


Phe Pro  Ile Ser Val Ala Asp  Leu Arg His Val Ala  Pro Asp Val 
    1250                 1255                 1260             


Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp Ala Lys  Ser His Gln 
    1265                 1270                 1275             


Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala Leu Thr  Leu Leu Pro 
    1280                 1285                 1290             


Gly Glu  Arg Thr Arg Leu His  Val Asp Leu Asp Met  Gln Ala Ala 
    1295                 1300                 1305             


Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala Asp Leu  Ala Ala Leu 
    1310                 1315                 1320             


Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly Tyr Thr  Tyr Arg Glu 
    1325                 1330                 1335             


Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr Leu Pro  Gln Pro Val 
    1340                 1345                 1350             


Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln Arg Ile  Pro Gln Leu 
    1355                 1360                 1365             


Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala Gly Gly  Glu Arg Asp 
    1370                 1375                 1380             


Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp Leu Asp  Pro Gln Thr 
    1385                 1390                 1395             


Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala Arg Gly  Ile Thr Pro 
    1400                 1405                 1410             


Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn Val Leu  Ala Arg Trp 
    1415                 1420                 1425             


Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu Pro Leu  Phe Ser Arg 
    1430                 1435                 1440             


Gln Ala  Leu His Pro Asp Val  Asp Leu Leu Val Gly  Asp Phe Thr 
    1445                 1450                 1455             


Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly Asp Thr  Val Ser Asn 
    1460                 1465                 1470             


Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr Glu Asp  Trp Glu His 
    1475                 1480                 1485             


Arg His  Trp Ser Gly Val Glu  Leu Leu Arg Glu Leu  Lys Arg Gln 
    1490                 1495                 1500             


Gln Arg  Tyr Pro His Gly Ala  Pro Val Val Phe Thr  Ser Asn Leu 
    1505                 1510                 1515             


Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu Ser Pro  Leu Gly Glu 
    1520                 1525                 1530             


Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln Val Trp  Ile Asp His 
    1535                 1540                 1545             


Leu Ala  Phe Glu His His Gly  Glu Val Trp Leu Gln  Trp Asp Ser 
    1550                 1555                 1560             


Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val Glu Thr  Leu Phe Asp 
    1565                 1570                 1575             


Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys Asp Asp  Glu Ser Ala 
    1580                 1585                 1590             


Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro Ala Ser  Gln Arg Ala 
    1595                 1600                 1605             


Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala Pro Ile  Pro Glu Gly 
    1610                 1615                 1620             


Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala Leu Gln  Gln Pro Gln 
    1625                 1630                 1635             


Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln Trp Asn  Ser Tyr Arg 
    1640                 1645                 1650             


Glu Met  Arg Glu Gln Val Val  Ala Leu Ala Asn Leu  Leu Arg Glu 
    1655                 1660                 1665             


Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala Val Ala  Leu Pro Arg 
    1670                 1675                 1680             


Ser Val  Phe Leu Thr Leu Ala  Leu His Ala Ile Val  Glu Ala Gly 
    1685                 1690                 1695             


Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr Pro Asp  Asp Arg Leu 
    1700                 1705                 1710             


Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser Leu Leu  Ile Thr Thr 
    1715                 1720                 1725             


Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val Pro Asn  Leu Thr Ser 
    1730                 1735                 1740             


Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln Gly Ser  Ala Pro Leu 
    1745                 1750                 1755             


Gln Leu  Ser Gln Pro His His  Thr Ala Tyr Ile Ile  Phe Thr Ser 
    1760                 1765                 1770             


Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met Val Gly  Gln Thr Ala 
    1775                 1780                 1785             


Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn His Tyr  Pro Leu Thr 
    1790                 1795                 1800             


Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro Cys Ser  Phe Asp Val 
    1805                 1810                 1815             


Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile Ala Gly  Ala Lys Leu 
    1820                 1825                 1830             


Val Met  Ala Glu Pro Glu Ala  His Arg Asp Pro Leu  Ala Met Gln 
    1835                 1840                 1845             


Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr Thr His  Phe Val Pro 
    1850                 1855                 1860             


Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu Thr Pro  Gln Thr Ala 
    1865                 1870                 1875             


Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val Phe Cys  Ser Gly Glu 
    1880                 1885                 1890             


Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp Gln Gln  Leu Thr Gly 
    1895                 1900                 1905             


Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr Glu Ala  Ala Val Asp 
    1910                 1915                 1920             


Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu Leu Ala  Gln Val Arg 
    1925                 1930                 1935             


Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val Trp Asn  Thr Gly Leu 
    1940                 1945                 1950             


Arg Ile  Leu Asp Ala Met Met  His Pro Val Pro Pro  Gly Val Ala 
    1955                 1960                 1965             


Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu Ala Gln  Gly Tyr Leu 
    1970                 1975                 1980             


Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe Ile Ala  Asp Pro Phe 
    1985                 1990                 1995             


Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly Asp Val  Ala Arg Trp 
    2000                 2005                 2010             


Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly Arg Ser  Asp Asp Gln 
    2015                 2020                 2025             


Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu Gly Glu  Ile Asp Arg 
    2030                 2035                 2040             


Val Met  Gln Ala Leu Pro Asp  Val Glu Gln Ala Val  Ala Ser Cys 
    2045                 2050                 2055             


Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn Lys His  Leu Val Ala 
    2060                 2065                 2070             


Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys Thr Glu  Arg Ser Arg 
    2075                 2080                 2085             


Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser Phe Leu  Lys Glu Lys 
    2090                 2095                 2100             


Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile Val Ile  Leu Asp Ala 
    2105                 2110                 2115             


Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp Arg Arg  Ala Leu Pro 
    2120                 2125                 2130             


Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp Lys Tyr  Val Ala Pro 
    2135                 2140                 2145             


Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu 
    2150                 2155                 2160             


Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu 
    2165                 2170                 2175             


Gly Gly  His Ser Leu Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser 
    2180                 2185                 2190             


Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly Gln Val  Met Val Ala 
    2195                 2200                 2205             


Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile Asp Ala  Glu Pro Gly 
    2210                 2215                 2220             


Ile Gly  Ala Leu Val Pro Ala  Pro Val Val Ile Ala  Ala Gly Arg 
    2225                 2230                 2235             


Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met Ala Cys  Arg Leu Pro 
    2240                 2245                 2250             


Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp Glu Leu  Leu Arg Glu 
    2255                 2260                 2265             


Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr Asp Arg  Gly Trp Asp 
    2270                 2275                 2280             


Leu Ala  Arg Leu His His Pro  Asp Pro Asp Asn Pro  Gly Thr Ser 
    2285                 2290                 2295             


Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp Ala Ala  Gly Phe Asp 
    2300                 2305                 2310             


Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu Ala Ala  Ala Met Asp 
    2315                 2320                 2325             


Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser Trp Glu  Leu Val Glu 
    2330                 2335                 2340             


Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg Gly Thr  Ala Thr Gly 
    2345                 2350                 2355             


Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr Gly Glu  Asp Thr Ala 
    2360                 2365                 2370             


Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val Thr Gly  Val Ala Pro 
    2375                 2380                 2385             


Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr Met Gly  Leu Glu Gly 
    2390                 2395                 2400             


Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser Ser Ser  Leu Val Ala 
    2405                 2410                 2415             


Leu His  Leu Ala Val Glu Ser  Leu Arg Lys Gly Glu  Ser Ser Met 
    2420                 2425                 2430             


Ala Val  Val Gly Gly Ala Ala  Val Met Ala Thr Pro  Gly Val Phe 
    2435                 2440                 2445             


Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala Ala Asp  Gly Arg Ser 
    2450                 2455                 2460             


Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe Gly Phe  Ser Glu Gly 
    2465                 2470                 2475             


Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser Glu Ala  Arg Arg Asn 
    2480                 2485                 2490             


Gly His  Glu Val Leu Ala Val  Val Arg Gly Ser Ala  Leu Asn Gln 
    2495                 2500                 2505             


Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro Ser Gly  Pro Ala Gln 
    2510                 2515                 2520             


Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser Cys Gly  Leu Glu Pro 
    2525                 2530                 2535             


Gly Asp  Val Asp Ala Val Glu  Ala His Gly Thr Gly  Thr Ala Leu 
    2540                 2545                 2550             


Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu Asp Thr  Tyr Gly Arg 
    2555                 2560                 2565             


Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu Gly Ser  Val Lys Ser 
    2570                 2575                 2580             


Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly Val Thr  Gly Leu Leu 
    2585                 2590                 2595             


Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu Leu Pro  Ala Thr Leu 
    2600                 2605                 2610             


His Val  Glu Glu Pro Thr Pro  His Val Asp Trp Ser  Ser Gly Gly 
    2615                 2620                 2625             


Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg 
    2630                 2635                 2640             


Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn 
    2645                 2650                 2655             


Ala His  Val Ile Val Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala 
    2660                 2665                 2670             


Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser Thr Leu  Val Val Ala 
    2675                 2680                 2685             


Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala 
    2690                 2695                 2700             


Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val 
    2705                 2710                 2715             


Ala His  Thr Leu Asn His His  Arg Ser Arg Gln Pro  Lys Phe Gly 
    2720                 2725                 2730             


Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg 
    2735                 2740                 2745             


Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly Val Val  Asn Pro Ala 
    2750                 2755                 2760             


Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln 
    2765                 2770                 2775             


Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe 
    2780                 2785                 2790             


Pro Val  Phe Ala Arg Ile His  Gln Gln Val Trp Asp  Leu Leu Asp 
    2795                 2800                 2805             


Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala 
    2810                 2815                 2820             


Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp 
    2825                 2830                 2835             


Gly Val  Arg Pro Asp Ala Val  Val Gly His Ser Val  Gly Glu Leu 
    2840                 2845                 2850             


Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys 
    2855                 2860                 2865             


Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala 
    2870                 2875                 2880             


Gly Gly  Val Met Ala Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg 
    2885                 2890                 2895             


Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro 
    2900                 2905                 2910             


Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala 
    2915                 2920                 2925             


Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala 
    2930                 2935                 2940             


Phe His  Ser Ala Arg Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala 
    2945                 2950                 2955             


Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala 
    2960                 2965                 2970             


Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val 
    2975                 2980                 2985             


Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp 
    2990                 2995                 3000             


Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu 
    3005                 3010                 3015             


Val Asp  Gly Ile Ala Met Leu  His Gly Asp His Glu  Ala Gln Ala 
    3020                 3025                 3030             


Gly Met  Arg Arg Glu Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu 
    3035                 3040                 3045             


Leu Thr  Asp Leu His Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val 
    3050                 3055                 3060             


Leu Cys  Pro Gln Gly Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp 
    3065                 3070                 3075             


Ser His  Arg Phe Leu Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg 
    3080                 3085                 3090             


Ser Pro  Gly Gly Ser Thr Val  Ala Val His Pro Leu  Leu Leu Ala 
    3095                 3100                 3105             


Ala Val  Asp Val Pro Gly His  Gly Gly Ala Val Phe  Thr Gly Arg 
    3110                 3115                 3120             


Leu Ser  Thr Asp Glu Gln Pro  Trp Leu Ala Glu His  Val Val Gly 
    3125                 3130                 3135             


Gly Arg  Thr Leu Val Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu 
    3140                 3145                 3150             


Ala Ala  Gly Glu Asp Val Gly  Leu Pro Val Leu Glu  Glu Leu Val 
    3155                 3160                 3165             


Leu Gln  Arg Pro Leu Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg 
    3170                 3175                 3180             


Met Ser  Val Gly Ala Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp 
    3185                 3190                 3195             


Val His  Ala Ala Glu Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp 
    3200                 3205                 3210             


Ser Gln  His Ala Thr Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly 
    3215                 3220                 3225             


Pro Arg  Asp Thr Glu Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile 
    3230                 3235                 3240             


Pro Leu  Asp Asp His Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu 
    3245                 3250                 3255             


Tyr Gly  Pro Ser Phe Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp 
    3260                 3265                 3270             


Ala Thr  Ala Thr Met Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile 
    3275                 3280                 3285             


Arg Ser  Gln Gln Gly Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp 
    3290                 3295                 3300             


Ala Cys  Phe Gln Ser Val Gly  Ala His Pro Asp Ser  Gln Ser Val 
    3305                 3310                 3315             


Gly Ser  Gly Leu Leu Val Pro  Leu Gly Val Arg Arg  Val Arg Ala 
    3320                 3325                 3330             


Tyr Ala  Pro Val Arg Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr 
    3335                 3340                 3345             


Lys Val  Glu Leu Ala Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp 
    3350                 3355                 3360             


Ala His  Gly Thr Val Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly 
    3365                 3370                 3375             


Thr Gly  Val Ser Glu Arg Asp  Lys His Asn Arg Val  Leu Asn Glu 
    3380                 3385                 3390             


Arg Leu  Leu Thr Ile Glu Trp  His Gln Arg Glu Leu  Pro Glu Met 
    3395                 3400                 3405             


Asp Pro  Ser Gly Ala Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala 
    3410                 3415                 3420             


Ala Ser  Asp Val Thr Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu 
    3425                 3430                 3435             


His Ser  Ala Ala Cys Thr Thr  Met Arg Trp Pro Leu  His Asp Asp 
    3440                 3445                 3450             


Gln Leu  Ala Ala Ala Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp 
    3455                 3460                 3465             


Glu Phe  Ser Gly Val Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr 
    3470                 3475                 3480             


Pro His  Gln Gly Ser Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg 
    3485                 3490                 3495             


Leu Val  Gly Ile Ala Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val 
    3500                 3505                 3510             


Pro Arg  Met Tyr Val Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala 
    3515                 3520                 3525             


Asp Asp  Cys Val Asn Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu 
    3530                 3535                 3540             


Arg Thr  Ile Gly Ala Glu His  Pro His Leu Arg Ala  Thr Gln Ile 
    3545                 3550                 3555             


Asp Val  Asp Glu Gln Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu 
    3560                 3565                 3570             


Leu Ala  Thr Ser Glu Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu 
    3575                 3580                 3585             


Trp Tyr  Val Ala Arg Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu 
    3590                 3595                 3600             


Arg Arg  Thr Ile Val Ala Asp  His Gln Gln Ser Gly  Met Arg Leu 
    3605                 3610                 3615             


Gln Ile  Arg Thr Pro Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro 
    3620                 3625                 3630             


Ala Pro  Asp Val Glu Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val 
    3635                 3640                 3645             


Asp Val  Arg Ala Thr Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala 
    3650                 3655                 3660             


Leu Gly  Met Tyr Pro Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala 
    3665                 3670                 3675             


Gly Val  Val Thr Ala Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro 
    3680                 3685                 3690             


Gly Asp  Arg Val Leu Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile 
    3695                 3700                 3705             


Ala Val  Thr Asp His Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp 
    3710                 3715                 3720             


Ser Asp  Ala Asp Ala Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala 
    3725                 3730                 3735             


His Tyr  Ala Leu His Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser 
    3740                 3745                 3750             


Val Leu  Ile His Ala Ala Ala  Gly Gly Val Gly Met  Ala Ala Val 
    3755                 3760                 3765             


Ala Leu  Ala Arg Arg Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly 
    3770                 3775                 3780             


Pro Ala  Lys His Gly Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu 
    3785                 3790                 3795             


His Ile  Ala Ser Ser Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg 
    3800                 3805                 3810             


Glu Arg  Thr Gly Gly Arg Gly  Val Asp Val Val Leu  Asn Ser Leu 
    3815                 3820                 3825             


Thr Gly  Glu Leu Leu Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp 
    3830                 3835                 3840             


Gly Val  Phe Val Glu Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly 
    3845                 3850                 3855             


Asp Phe  Arg Gly Arg Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly 
    3860                 3865                 3870             


Asp Asp  Arg Leu Gly Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu 
    3875                 3880                 3885             


Gly Ala  Gly Glu Leu Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu 
    3890                 3895                 3900             


Gly Ile  Pro Gln Thr Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu 
    3905                 3910                 3915             


Gln Ala  Gln Val Phe Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly 
    3920                 3925                 3930             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    3935                 3940                 3945             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    3950                 3955                 3960             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    3965                 3970                 3975             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    3980                 3985                 3990             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    3995                 4000                 4005             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    4010                 4015                 4020             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    4025                 4030                 4035             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    4040                 4045                 4050             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    4055                 4060                 4065             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    4070                 4075                 4080             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    4085                 4090                 4095             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    4100                 4105                 4110             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    4115                 4120                 4125             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    4130                 4135                 4140             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    4145                 4150                 4155             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    4160                 4165                 4170             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    4175                 4180                 4185             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    4190                 4195                 4200             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    4205                 4210                 4215             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    4220                 4225                 4230             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    4235                 4240                 4245             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    4250                 4255                 4260             


Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys 
    4265                 4270                 4275             


Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly 
    4280                 4285                 4290             


Pro Pro  Val Glu His Arg Ala  Arg Leu Val Cys Phe  Pro His Ala 
    4295                 4300                 4305             


Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala 
    4310                 4315                 4320             


Pro Glu  Ile Asp Val His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp 
    4325                 4330                 4335             


Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp 
    4340                 4345                 4350             


Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe 
    4355                 4360                 4365             


Ala Leu  Phe Gly His Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr 
    4370                 4375                 4380             


Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu 
    4385                 4390                 4395             


Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val His Glu  Arg Arg Thr 
    4400                 4405                 4410             


Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu 
    4415                 4420                 4425             


Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met 
    4430                 4435                 4440             


Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr 
    4445                 4450                 4455             


Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu 
    4460                 4465                 4470             


Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg 
    4475                 4480                 4485             


Trp Leu  Gln His Ser Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro 
    4490                 4495                 4500             


Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly 
    4505                 4510                 4515             


Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly Leu Ala  Gly 
    4520                 4525                 4530     


<210>  35
<211>  3980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICO

<400>  35

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gly Glu Pro 
    1160                 1165                 1170             


Phe Pro  Leu Ala Pro Met Gln  His Ala Met Trp Val  Gly Arg His 
    1175                 1180                 1185             


Asp His  Gln Gln Leu Gly Gly  Val Ala Gly His Leu  Tyr Val Glu 
    1190                 1195                 1200             


Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg Leu Arg  Ala Ala Ala 
    1205                 1210                 1215             


Thr Arg  Leu Ala Leu Arg His  Pro Met Leu Arg Val  Gln Phe Leu 
    1220                 1225                 1230             


Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala Ala Gly  Ser Arg Asp 
    1235                 1240                 1245             


Phe Pro  Ile Ser Val Ala Asp  Leu Arg His Val Ala  Pro Asp Val 
    1250                 1255                 1260             


Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp Ala Lys  Ser His Gln 
    1265                 1270                 1275             


Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala Leu Thr  Leu Leu Pro 
    1280                 1285                 1290             


Gly Glu  Arg Thr Arg Leu His  Val Asp Leu Asp Met  Gln Ala Ala 
    1295                 1300                 1305             


Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala Asp Leu  Ala Ala Leu 
    1310                 1315                 1320             


Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly Tyr Thr  Tyr Arg Glu 
    1325                 1330                 1335             


Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr Leu Pro  Gln Pro Val 
    1340                 1345                 1350             


Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln Arg Ile  Pro Gln Leu 
    1355                 1360                 1365             


Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala Gly Gly  Glu Arg Asp 
    1370                 1375                 1380             


Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp Leu Asp  Pro Gln Thr 
    1385                 1390                 1395             


Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala Arg Gly  Ile Thr Pro 
    1400                 1405                 1410             


Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn Val Leu  Ala Arg Trp 
    1415                 1420                 1425             


Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu Pro Leu  Phe Ser Arg 
    1430                 1435                 1440             


Gln Ala  Leu His Pro Asp Val  Asp Leu Leu Val Gly  Asp Phe Thr 
    1445                 1450                 1455             


Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly Asp Thr  Val Ser Asn 
    1460                 1465                 1470             


Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr Glu Asp  Trp Glu His 
    1475                 1480                 1485             


Arg His  Trp Ser Gly Val Glu  Leu Leu Arg Glu Leu  Lys Arg Gln 
    1490                 1495                 1500             


Gln Arg  Tyr Pro His Gly Ala  Pro Val Val Phe Thr  Ser Asn Leu 
    1505                 1510                 1515             


Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu Ser Pro  Leu Gly Glu 
    1520                 1525                 1530             


Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln Val Trp  Ile Asp His 
    1535                 1540                 1545             


Leu Ala  Phe Glu His His Gly  Glu Val Trp Leu Gln  Trp Asp Ser 
    1550                 1555                 1560             


Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val Glu Thr  Leu Phe Asp 
    1565                 1570                 1575             


Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys Asp Asp  Glu Ser Ala 
    1580                 1585                 1590             


Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro Ala Ser  Gln Arg Ala 
    1595                 1600                 1605             


Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala Pro Ile  Pro Glu Gly 
    1610                 1615                 1620             


Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala Leu Gln  Gln Pro Gln 
    1625                 1630                 1635             


Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln Trp Asn  Ser Tyr Arg 
    1640                 1645                 1650             


Glu Met  Arg Glu Gln Val Val  Ala Leu Ala Asn Leu  Leu Arg Glu 
    1655                 1660                 1665             


Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala Val Ala  Leu Pro Arg 
    1670                 1675                 1680             


Ser Val  Phe Leu Thr Leu Ala  Leu His Ala Ile Val  Glu Ala Gly 
    1685                 1690                 1695             


Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr Pro Asp  Asp Arg Leu 
    1700                 1705                 1710             


Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser Leu Leu  Ile Thr Thr 
    1715                 1720                 1725             


Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val Pro Asn  Leu Thr Ser 
    1730                 1735                 1740             


Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln Gly Ser  Ala Pro Leu 
    1745                 1750                 1755             


Gln Leu  Ser Gln Pro His His  Thr Ala Tyr Ile Ile  Phe Thr Ser 
    1760                 1765                 1770             


Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met Val Gly  Gln Thr Ala 
    1775                 1780                 1785             


Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn His Tyr  Pro Leu Thr 
    1790                 1795                 1800             


Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro Cys Ser  Phe Asp Val 
    1805                 1810                 1815             


Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile Ala Gly  Ala Lys Leu 
    1820                 1825                 1830             


Val Met  Ala Glu Pro Glu Ala  His Arg Asp Pro Leu  Ala Met Gln 
    1835                 1840                 1845             


Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr Thr His  Phe Val Pro 
    1850                 1855                 1860             


Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu Thr Pro  Gln Thr Ala 
    1865                 1870                 1875             


Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val Phe Cys  Ser Gly Glu 
    1880                 1885                 1890             


Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp Gln Gln  Leu Thr Gly 
    1895                 1900                 1905             


Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr Glu Ala  Ala Val Asp 
    1910                 1915                 1920             


Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu Leu Ala  Gln Val Arg 
    1925                 1930                 1935             


Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val Trp Asn  Thr Gly Leu 
    1940                 1945                 1950             


Arg Ile  Leu Asp Ala Met Met  His Pro Val Pro Pro  Gly Val Ala 
    1955                 1960                 1965             


Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu Ala Gln  Gly Tyr Leu 
    1970                 1975                 1980             


Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe Ile Ala  Asp Pro Phe 
    1985                 1990                 1995             


Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly Asp Val  Ala Arg Trp 
    2000                 2005                 2010             


Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly Arg Ser  Asp Asp Gln 
    2015                 2020                 2025             


Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu Gly Glu  Ile Asp Arg 
    2030                 2035                 2040             


Val Met  Gln Ala Leu Pro Asp  Val Glu Gln Ala Val  Ala Ser Cys 
    2045                 2050                 2055             


Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn Lys His  Leu Val Ala 
    2060                 2065                 2070             


Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys Thr Glu  Arg Ser Arg 
    2075                 2080                 2085             


Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser Phe Leu  Lys Glu Lys 
    2090                 2095                 2100             


Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile Val Ile  Leu Asp Ala 
    2105                 2110                 2115             


Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp Arg Arg  Ala Leu Pro 
    2120                 2125                 2130             


Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp Lys Tyr  Val Ala Pro 
    2135                 2140                 2145             


Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu 
    2150                 2155                 2160             


Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu 
    2165                 2170                 2175             


Gly Gly  His Ser Leu Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser 
    2180                 2185                 2190             


Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly Gln Val  Met Val Ala 
    2195                 2200                 2205             


Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile Asp Ala  Glu Pro Gly 
    2210                 2215                 2220             


Ile Gly  Ala Leu Val Pro Ala  Pro Val Val Ile Ala  Ala Gly Arg 
    2225                 2230                 2235             


Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met Ala Cys  Arg Leu Pro 
    2240                 2245                 2250             


Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp Glu Leu  Leu Arg Glu 
    2255                 2260                 2265             


Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr Asp Arg  Gly Trp Asp 
    2270                 2275                 2280             


Leu Ala  Arg Leu His His Pro  Asp Pro Asp Asn Pro  Gly Thr Ser 
    2285                 2290                 2295             


Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp Ala Ala  Gly Phe Asp 
    2300                 2305                 2310             


Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu Ala Ala  Ala Met Asp 
    2315                 2320                 2325             


Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser Trp Glu  Leu Val Glu 
    2330                 2335                 2340             


Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg Gly Thr  Ala Thr Gly 
    2345                 2350                 2355             


Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr Gly Glu  Asp Thr Ala 
    2360                 2365                 2370             


Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val Thr Gly  Val Ala Pro 
    2375                 2380                 2385             


Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr Met Gly  Leu Glu Gly 
    2390                 2395                 2400             


Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser Ser Ser  Leu Val Ala 
    2405                 2410                 2415             


Leu His  Leu Ala Val Glu Ser  Leu Arg Lys Gly Glu  Ser Ser Met 
    2420                 2425                 2430             


Ala Val  Val Gly Gly Ala Ala  Val Met Ala Thr Pro  Gly Val Phe 
    2435                 2440                 2445             


Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala Ala Asp  Gly Arg Ser 
    2450                 2455                 2460             


Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe Gly Phe  Ser Glu Gly 
    2465                 2470                 2475             


Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser Glu Ala  Arg Arg Asn 
    2480                 2485                 2490             


Gly His  Glu Val Leu Ala Val  Val Arg Gly Ser Ala  Leu Asn Gln 
    2495                 2500                 2505             


Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro Ser Gly  Pro Ala Gln 
    2510                 2515                 2520             


Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser Cys Gly  Leu Glu Pro 
    2525                 2530                 2535             


Gly Asp  Val Asp Ala Val Glu  Ala His Gly Thr Gly  Thr Ala Leu 
    2540                 2545                 2550             


Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu Asp Thr  Tyr Gly Arg 
    2555                 2560                 2565             


Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu Gly Ser  Val Lys Ser 
    2570                 2575                 2580             


Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly Val Thr  Gly Leu Leu 
    2585                 2590                 2595             


Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu Leu Pro  Ala Thr Leu 
    2600                 2605                 2610             


His Val  Glu Glu Pro Thr Pro  His Val Asp Trp Ser  Ser Gly Gly 
    2615                 2620                 2625             


Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg 
    2630                 2635                 2640             


Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn 
    2645                 2650                 2655             


Ala His  Val Ile Val Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala 
    2660                 2665                 2670             


Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser Thr Leu  Val Val Ala 
    2675                 2680                 2685             


Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala 
    2690                 2695                 2700             


Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val 
    2705                 2710                 2715             


Ala His  Thr Leu Asn His His  Arg Ser Arg Gln Pro  Lys Phe Gly 
    2720                 2725                 2730             


Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg 
    2735                 2740                 2745             


Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly Val Val  Asn Pro Ala 
    2750                 2755                 2760             


Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln 
    2765                 2770                 2775             


Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe 
    2780                 2785                 2790             


Pro Val  Phe Ala Arg Ile His  Gln Gln Val Trp Asp  Leu Leu Asp 
    2795                 2800                 2805             


Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala 
    2810                 2815                 2820             


Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp 
    2825                 2830                 2835             


Gly Val  Arg Pro Asp Ala Val  Val Gly His Ser Val  Gly Glu Leu 
    2840                 2845                 2850             


Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys 
    2855                 2860                 2865             


Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala 
    2870                 2875                 2880             


Gly Gly  Val Met Ala Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg 
    2885                 2890                 2895             


Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro 
    2900                 2905                 2910             


Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala 
    2915                 2920                 2925             


Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala 
    2930                 2935                 2940             


Phe His  Ser Ala Arg Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala 
    2945                 2950                 2955             


Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala 
    2960                 2965                 2970             


Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val 
    2975                 2980                 2985             


Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp 
    2990                 2995                 3000             


Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu 
    3005                 3010                 3015             


Val Asp  Gly Ile Ala Met Leu  His Gly Asp His Glu  Ala Gln Ala 
    3020                 3025                 3030             


Ala Asp  His Arg Gln Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val 
    3035                 3040                 3045             


Leu Gly  His Leu Pro Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala 
    3050                 3055                 3060             


Arg Lys  Leu Asp Leu Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr 
    3065                 3070                 3075             


Trp Phe  Arg Asp Ala Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr 
    3080                 3085                 3090             


Gly Gly  Pro Arg Thr Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg 
    3095                 3100                 3105             


Ile Glu  Glu Leu Ala Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln 
    3110                 3115                 3120             


His Thr  Leu Gln Val Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln 
    3125                 3130                 3135             


Gln Arg  Thr Thr Arg Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg 
    3140                 3145                 3150             


Trp Asp  Arg Ser Thr Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln 
    3155                 3160                 3165             


Ala Gly  Ser Trp Ile Val Val  Ser Asp Asp Ala Asp  Ala Val Pro 
    3170                 3175                 3180             


Pro Leu  Val Asp Leu Leu Ala  Ala Arg Asn Glu Pro  His Gln Val 
    3185                 3190                 3195             


Val Gly  Leu Pro Ala Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu 
    3200                 3205                 3210             


Thr Leu  Arg Ala Ala Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val 
    3215                 3220                 3225             


His Val  Ala Ala Leu Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser 
    3230                 3235                 3240             


Leu Leu  Arg Met Gln His Arg  Ile Leu Gly Gly Thr  Arg Arg Val 
    3245                 3250                 3255             


Phe Arg  Ala Ala Val Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile 
    3260                 3265                 3270             


Val Thr  Arg Gly Ala Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala 
    3275                 3280                 3285             


Pro His  Gln Ser Cys Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu 
    3290                 3295                 3300             


Glu Leu  Pro His Val Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly 
    3305                 3310                 3315             


Gly Asp  Asn Ala Ala Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile 
    3320                 3325                 3330             


Ala Ala  Pro His Gly Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu 
    3335                 3340                 3345             


Arg Asp  Arg Ala Val Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala 
    3350                 3355                 3360             


Pro Pro  Ser Gly Thr Pro Leu  His Leu Arg Gly Asp  Gly Thr Val 
    3365                 3370                 3375             


Leu Ile  Thr Gly Gly Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg 
    3380                 3385                 3390             


His Leu  Val Thr Glu His Gly  Val Arg His Leu Leu  Leu Val Ser 
    3395                 3400                 3405             


Arg Arg  Gly Ala Asp Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu 
    3410                 3415                 3420             


Ile Glu  Asp Leu Gly Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr 
    3425                 3430                 3435             


Ala Asp  Arg Asp Ala Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg 
    3440                 3445                 3450             


Pro Leu  Thr Gly Val Val His  Ala Ala Gly Val Leu  Ala Asp Gly 
    3455                 3460                 3465             


Leu Val  Thr Ser Ile Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg 
    3470                 3475                 3480             


Ala Lys  Val Asp Ala Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn 
    3485                 3490                 3495             


Thr Gly  Leu Ser Phe Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val 
    3500                 3505                 3510             


Leu Ala  Gly Pro Gly Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser 
    3515                 3520                 3525             


Leu Asn  Ala Leu Ala Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala 
    3530                 3535                 3540             


Lys Ala  Leu Gly Trp Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala 
    3545                 3550                 3555             


Phe Ala  Glu Gln Thr Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala 
    3560                 3565                 3570             


Tyr Ala  Phe Glu Thr Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly 
    3575                 3580                 3585             


Tyr Ala  Pro Val Ile Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln 
    3590                 3595                 3600             


His Ser  Pro Phe Ala Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg 
    3605                 3610                 3615             


Ser Gly  Thr Ser Lys Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg 
    3620                 3625                 3630             


Glu Glu  Trp Pro Asp Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg 
    3635                 3640                 3645             


Ser His  Ala Ala Ala Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu 
    3650                 3655                 3660             


Pro Glu  Arg Lys Ala Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala 
    3665                 3670                 3675             


Ala Val  Glu Leu Arg Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg 
    3680                 3685                 3690             


Leu Pro  Ser Thr Leu Val Phe  Asp His Pro Thr Pro  Leu Ala Val 
    3695                 3700                 3705             


Ala Glu  His Leu Arg Asp Arg  Leu Thr Ser Gly Glu  Asp Asn Pro 
    3710                 3715                 3720             


Ile Pro  Leu Cys Gln Gly Asp  Gly Glu Glu Met Ser  Thr Trp Leu 
    3725                 3730                 3735             


Arg Arg  Phe Gly Pro Pro Val  Glu His Arg Ala Arg  Leu Val Cys 
    3740                 3745                 3750             


Phe Pro  His Ala Gly Ala Ala  Ala Asp Ser Tyr Leu  Asp Leu Ala 
    3755                 3760                 3765             


Arg Ala  Leu Ala Pro Glu Ile  Asp Val His Ala Val  Gln Tyr Pro 
    3770                 3775                 3780             


Gly Arg  Gln Asp Arg Arg Asp  Glu Glu Pro Leu Gly  Thr Ala Gly 
    3785                 3790                 3795             


Glu Ile  Ala Asp Glu Val Ala  Ala Val Leu Arg Ala  Ser Gly Gly 
    3800                 3805                 3810             


Asp Gly  Pro Phe Ala Leu Phe  Gly His Ser Met Gly  Ala Leu Ile 
    3815                 3820                 3825             


Ala Tyr  Glu Thr Ala Arg Arg  Leu Glu Arg Glu Pro  Gly Gly Gly 
    3830                 3835                 3840             


Pro Leu  Arg Leu Phe Val Ser  Gly Gln Thr Ala Pro  Arg Val His 
    3845                 3850                 3855             


Glu Arg  Arg Thr Asp Leu Pro  Gly Asp Asp Gly Leu  Val Asp Glu 
    3860                 3865                 3870             


Leu Arg  Arg Leu Gly Thr Ser  Glu Ala Ala Leu Ala  Asp Glu Ala 
    3875                 3880                 3885             


Leu Leu  Ala Met Ser Leu Pro  Val Leu Arg Ala Asp  Tyr Arg Val 
    3890                 3895                 3900             


Leu Arg  Ser Tyr Ala Trp Ala  Asp Gly Pro Pro Leu  Arg Ala Gly 
    3905                 3910                 3915             


Ile Thr  Ala Leu Cys Gly Asp  Ala Asp Pro Leu Thr  Ala Thr Gly 
    3920                 3925                 3930             


Asp Ala  Glu Arg Trp Leu Gln  His Ser Val Ile Pro  Gly Arg Thr 
    3935                 3940                 3945             


Arg Thr  Phe Pro Gly Gly His  Phe Tyr Leu Gly Glu  Gln Val Thr 
    3950                 3955                 3960             


Glu Val  Ala Gly Ala Val Arg  Arg Asp Leu Leu Arg  Ala Gly Leu 
    3965                 3970                 3975             


Ala Gly  
    3980 


<210>  36
<211>  4093
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICS

<400>  36

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gly Glu Pro 
    1160                 1165                 1170             


Phe Pro  Leu Ala Pro Met Gln  His Ala Met Trp Val  Gly Arg His 
    1175                 1180                 1185             


Asp His  Gln Gln Leu Gly Gly  Val Ala Gly His Leu  Tyr Val Glu 
    1190                 1195                 1200             


Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg Leu Arg  Ala Ala Ala 
    1205                 1210                 1215             


Thr Arg  Leu Ala Leu Arg His  Pro Met Leu Arg Val  Gln Phe Leu 
    1220                 1225                 1230             


Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala Ala Gly  Ser Arg Asp 
    1235                 1240                 1245             


Phe Pro  Ile Ser Val Ala Asp  Leu Arg His Val Ala  Pro Asp Val 
    1250                 1255                 1260             


Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp Ala Lys  Ser His Gln 
    1265                 1270                 1275             


Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala Leu Thr  Leu Leu Pro 
    1280                 1285                 1290             


Gly Glu  Arg Thr Arg Leu His  Val Asp Leu Asp Met  Gln Ala Ala 
    1295                 1300                 1305             


Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala Asp Leu  Ala Ala Leu 
    1310                 1315                 1320             


Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly Tyr Thr  Tyr Arg Glu 
    1325                 1330                 1335             


Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr Leu Pro  Gln Pro Val 
    1340                 1345                 1350             


Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln Arg Ile  Pro Gln Leu 
    1355                 1360                 1365             


Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala Gly Gly  Glu Arg Asp 
    1370                 1375                 1380             


Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp Leu Asp  Pro Gln Thr 
    1385                 1390                 1395             


Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala Arg Gly  Ile Thr Pro 
    1400                 1405                 1410             


Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn Val Leu  Ala Arg Trp 
    1415                 1420                 1425             


Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu Pro Leu  Phe Ser Arg 
    1430                 1435                 1440             


Gln Ala  Leu His Pro Asp Val  Asp Leu Leu Val Gly  Asp Phe Thr 
    1445                 1450                 1455             


Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly Asp Thr  Val Ser Asn 
    1460                 1465                 1470             


Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr Glu Asp  Trp Glu His 
    1475                 1480                 1485             


Arg His  Trp Ser Gly Val Glu  Leu Leu Arg Glu Leu  Lys Arg Gln 
    1490                 1495                 1500             


Gln Arg  Tyr Pro His Gly Ala  Pro Val Val Phe Thr  Ser Asn Leu 
    1505                 1510                 1515             


Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu Ser Pro  Leu Gly Glu 
    1520                 1525                 1530             


Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln Val Trp  Ile Asp His 
    1535                 1540                 1545             


Leu Ala  Phe Glu His His Gly  Glu Val Trp Leu Gln  Trp Asp Ser 
    1550                 1555                 1560             


Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val Glu Thr  Leu Phe Asp 
    1565                 1570                 1575             


Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys Asp Asp  Glu Ser Ala 
    1580                 1585                 1590             


Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro Ala Ser  Gln Arg Ala 
    1595                 1600                 1605             


Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala Pro Ile  Pro Glu Gly 
    1610                 1615                 1620             


Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala Leu Gln  Gln Pro Gln 
    1625                 1630                 1635             


Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln Trp Asn  Ser Tyr Arg 
    1640                 1645                 1650             


Glu Met  Arg Glu Gln Val Val  Ala Leu Ala Asn Leu  Leu Arg Glu 
    1655                 1660                 1665             


Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala Val Ala  Leu Pro Arg 
    1670                 1675                 1680             


Ser Val  Phe Leu Thr Leu Ala  Leu His Ala Ile Val  Glu Ala Gly 
    1685                 1690                 1695             


Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr Pro Asp  Asp Arg Leu 
    1700                 1705                 1710             


Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser Leu Leu  Ile Thr Thr 
    1715                 1720                 1725             


Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val Pro Asn  Leu Thr Ser 
    1730                 1735                 1740             


Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln Gly Ser  Ala Pro Leu 
    1745                 1750                 1755             


Gln Leu  Ser Gln Pro His His  Thr Ala Tyr Ile Ile  Phe Thr Ser 
    1760                 1765                 1770             


Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met Val Gly  Gln Thr Ala 
    1775                 1780                 1785             


Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn His Tyr  Pro Leu Thr 
    1790                 1795                 1800             


Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro Cys Ser  Phe Asp Val 
    1805                 1810                 1815             


Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile Ala Gly  Ala Lys Leu 
    1820                 1825                 1830             


Val Met  Ala Glu Pro Glu Ala  His Arg Asp Pro Leu  Ala Met Gln 
    1835                 1840                 1845             


Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr Thr His  Phe Val Pro 
    1850                 1855                 1860             


Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu Thr Pro  Gln Thr Ala 
    1865                 1870                 1875             


Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val Phe Cys  Ser Gly Glu 
    1880                 1885                 1890             


Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp Gln Gln  Leu Thr Gly 
    1895                 1900                 1905             


Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr Glu Ala  Ala Val Asp 
    1910                 1915                 1920             


Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu Leu Ala  Gln Val Arg 
    1925                 1930                 1935             


Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val Trp Asn  Thr Gly Leu 
    1940                 1945                 1950             


Arg Ile  Leu Asp Ala Met Met  His Pro Val Pro Pro  Gly Val Ala 
    1955                 1960                 1965             


Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu Ala Gln  Gly Tyr Leu 
    1970                 1975                 1980             


Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe Ile Ala  Asp Pro Phe 
    1985                 1990                 1995             


Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly Asp Val  Ala Arg Trp 
    2000                 2005                 2010             


Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly Arg Ser  Asp Asp Gln 
    2015                 2020                 2025             


Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu Gly Glu  Ile Asp Arg 
    2030                 2035                 2040             


Val Met  Gln Ala Leu Pro Asp  Val Glu Gln Ala Val  Ala Ser Cys 
    2045                 2050                 2055             


Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn Lys His  Leu Val Ala 
    2060                 2065                 2070             


Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys Thr Glu  Arg Ser Arg 
    2075                 2080                 2085             


Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser Phe Leu  Lys Glu Lys 
    2090                 2095                 2100             


Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile Val Ile  Leu Asp Ala 
    2105                 2110                 2115             


Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp Arg Arg  Ala Leu Pro 
    2120                 2125                 2130             


Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp Lys Tyr  Val Ala Pro 
    2135                 2140                 2145             


Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu 
    2150                 2155                 2160             


Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu 
    2165                 2170                 2175             


Gly Gly  His Ser Leu Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser 
    2180                 2185                 2190             


Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly Gln Val  Met Val Ala 
    2195                 2200                 2205             


Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Pro 
    2210                 2215                 2220             


Val Glu  Gln Pro Phe Val His  Ser Pro Glu Glu Arg  Tyr Arg Pro 
    2225                 2230                 2235             


Phe Ala  Leu Thr Asp Val Gln  Gln Ala Tyr Leu Val  Gly Arg Gln 
    2240                 2245                 2250             


Pro Gly  Phe Ala Leu Gly Gly  Val Gly Ser His Phe  Phe Val Glu 
    2255                 2260                 2265             


Phe Glu  Ile Ala Asp Leu Asp  Ile His Arg Leu Glu  Lys Val Trp 
    2270                 2275                 2280             


Asn Arg  Leu Ile Ala Arg His  Asp Met Leu Arg Ala  Val Val Arg 
    2285                 2290                 2295             


Asp Gly  Gln Gln Arg Val Leu  Glu Gln Thr Pro Pro  Trp Val Ile 
    2300                 2305                 2310             


Pro Ala  His Ile Leu His Ser  Pro Glu Glu Ala Leu  Gln Val Arg 
    2315                 2320                 2325             


Asp Arg  Leu Ala His Gln Val  Leu Asn Pro Glu Val  Trp Pro Val 
    2330                 2335                 2340             


Phe Asp  Leu Gln Val Gly Phe  Val Asp Gly Met Pro  Ala Arg Leu 
    2345                 2350                 2355             


Trp Leu  Cys Leu Asp Asn Leu  Leu Leu Asp Gly Leu  Ser Met Gln 
    2360                 2365                 2370             


Ile Leu  Leu Ser Glu Leu Glu  His Gly Tyr Arg Tyr  Pro Gln Gln 
    2375                 2380                 2385             


Leu Pro  Pro Pro Leu Pro Ile  Thr Phe Arg Asp Tyr  Leu Gln Gln 
    2390                 2395                 2400             


Pro Ala  Leu Arg Thr Pro Asn  Pro Asp Ser Leu Ala  Trp Trp Gln 
    2405                 2410                 2415             


Thr Gln  Leu Asp Asp Ile Pro  Pro Ala Pro Ala Leu  Pro Leu Arg 
    2420                 2425                 2430             


Cys Leu  Pro Gln Asp Val Glu  Thr Pro Arg Phe Ala  Arg Leu Tyr 
    2435                 2440                 2445             


Gly Ala  Met Asp Ser Ala Arg  Trp Arg Arg Leu Lys  Gln Arg Ala 
    2450                 2455                 2460             


Ala Asp  Ala His Leu Thr Pro  Ser Ala Val Leu Leu  Ser Val Trp 
    2465                 2470                 2475             


Ser Thr  Val Leu Ala Ala Trp  Ser Ala Gln Pro Asp  Phe Thr Leu 
    2480                 2485                 2490             


Asn Leu  Thr Leu Phe Asp Arg  Arg Pro Leu His Pro  Gln Ile Asn 
    2495                 2500                 2505             


Gln Ile  Leu Gly Asp Phe Thr  Ser Leu Met Leu Leu  Ser Trp His 
    2510                 2515                 2520             


Pro Gly  Glu Ser Trp Leu Gln  Ser Ala Arg Leu Leu  Gln Gln Arg 
    2525                 2530                 2535             


Leu Ser  Glu Ser Leu Asn His  Arg Asp Val Ser Ala  Ile Arg Val 
    2540                 2545                 2550             


Met Arg  Gln Leu Ala Arg Arg  Gln Asn Val Pro Ala  Val Pro Met 
    2555                 2560                 2565             


Pro Val  Val Phe Thr Ser Ala  Leu Gly Phe Glu Gln  Asp Asn Phe 
    2570                 2575                 2580             


Leu Ala  Arg Arg Asn Leu Leu  Lys Pro Val Trp Gly  Ile Ser Gln 
    2585                 2590                 2595             


Thr Pro  Gln Val Trp Leu Asp  His Gln Val Tyr Glu  Ser Glu Gly 
    2600                 2605                 2610             


Glu Leu  Arg Phe Asn Trp Asp  Phe Val Ala Ala Leu  Phe Pro Asp 
    2615                 2620                 2625             


Gly Gln  Val Glu Arg Gln Phe  Ala Gln Tyr Cys Ala  Leu Leu Asn 
    2630                 2635                 2640             


Arg Met  Ala Glu Asp Asp Ser  Ser Trp Gln Leu Pro  Leu Ala Asp 
    2645                 2650                 2655             


Leu Val  Pro Pro Leu Lys Val  Thr Glu Arg Arg Ala  Arg Arg Leu 
    2660                 2665                 2670             


Arg Pro  Glu Arg Ala Gln Pro  Arg Ile Ala Ala Asp  Lys Ser Ser 
    2675                 2680                 2685             


Val Ser  Leu Ile Cys Asp Thr  Phe Arg Glu Val Val  Gly Glu Pro 
    2690                 2695                 2700             


Val Ala  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    2705                 2710                 2715             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ala 
    2720                 2725                 2730             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Val Ala 
    2735                 2740                 2745             


Leu Ala  Asn Tyr Leu Ala Gly  Val Ala Leu Glu Glu  Lys Thr Lys 
    2750                 2755                 2760             


Arg Val  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gln His Leu 
    2765                 2770                 2775             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    2780                 2785                 2790             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    2795                 2800                 2805             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    2810                 2815                 2820             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    2825                 2830                 2835             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    2840                 2845                 2850             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    2855                 2860                 2865             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    2870                 2875                 2880             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    2885                 2890                 2895             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    2900                 2905                 2910             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    2915                 2920                 2925             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    2930                 2935                 2940             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    2945                 2950                 2955             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    2960                 2965                 2970             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    2975                 2980                 2985             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    2990                 2995                 3000             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    3005                 3010                 3015             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    3020                 3025                 3030             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    3035                 3040                 3045             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    3050                 3055                 3060             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    3065                 3070                 3075             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    3080                 3085                 3090             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    3095                 3100                 3105             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    3110                 3115                 3120             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    3125                 3130                 3135             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    3140                 3145                 3150             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    3155                 3160                 3165             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    3170                 3175                 3180             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    3185                 3190                 3195             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    3200                 3205                 3210             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    3215                 3220                 3225             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    3230                 3235                 3240             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    3245                 3250                 3255             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    3260                 3265                 3270             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    3275                 3280                 3285             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    3290                 3295                 3300             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    3305                 3310                 3315             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    3320                 3325                 3330             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    3335                 3340                 3345             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    3350                 3355                 3360             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    3365                 3370                 3375             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    3380                 3385                 3390             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    3395                 3400                 3405             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    3410                 3415                 3420             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    3425                 3430                 3435             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    3440                 3445                 3450             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    3455                 3460                 3465             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    3470                 3475                 3480             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    3485                 3490                 3495             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    3500                 3505                 3510             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    3515                 3520                 3525             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    3530                 3535                 3540             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    3545                 3550                 3555             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    3560                 3565                 3570             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    3575                 3580                 3585             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    3590                 3595                 3600             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    3605                 3610                 3615             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    3620                 3625                 3630             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    3635                 3640                 3645             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    3650                 3655                 3660             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    3665                 3670                 3675             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    3680                 3685                 3690             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    3695                 3700                 3705             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    3710                 3715                 3720             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    3725                 3730                 3735             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    3740                 3745                 3750             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    3755                 3760                 3765             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    3770                 3775                 3780             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    3785                 3790                 3795             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    3800                 3805                 3810             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    3815                 3820                 3825             


Ile Thr  Ser Gly Glu Asp Asn  Pro Ile Pro Leu Cys  Gln Gly Asp 
    3830                 3835                 3840             


Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg Phe Gly  Pro Pro Val 
    3845                 3850                 3855             


Glu His  Arg Ala Arg Leu Val  Cys Phe Pro His Ala  Gly Ala Ala 
    3860                 3865                 3870             


Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala Leu Ala  Pro Glu Ile 
    3875                 3880                 3885             


Asp Val  His Ala Val Gln Tyr  Pro Gly Arg Gln Asp  Arg Arg Asp 
    3890                 3895                 3900             


Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile Ala Asp  Glu Val Ala 
    3905                 3910                 3915             


Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly Pro Phe  Ala Leu Phe 
    3920                 3925                 3930             


Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr Glu Thr  Ala Arg Arg 
    3935                 3940                 3945             


Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu Arg Leu  Phe Val Ser 
    3950                 3955                 3960             


Gly Gln  Thr Ala Pro Arg Val  His Glu Arg Arg Thr  Asp Leu Pro 
    3965                 3970                 3975             


Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg Arg Leu  Gly Thr Ser 
    3980                 3985                 3990             


Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu Ala Met  Ser Leu Pro 
    3995                 4000                 4005             


Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg Ser Tyr  Ala Trp Ala 
    4010                 4015                 4020             


Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr Ala Leu  Cys Gly Asp 
    4025                 4030                 4035             


Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala Glu Arg  Trp Leu Gln 
    4040                 4045                 4050             


His Ser  Val Ile Pro Gly Arg  Thr Arg Thr Phe Pro  Gly Gly His 
    4055                 4060                 4065             


Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val Ala Gly  Ala Val Arg 
    4070                 4075                 4080             


Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    4085                 4090             


<210>  37
<211>  4526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IHC

<400>  37

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Leu 
    2645                 2650                 2655             


Pro Val  Glu Gln Pro Phe Val  His Ser Pro Glu Glu  Arg Tyr Arg 
    2660                 2665                 2670             


Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala Tyr Leu  Val Gly Arg 
    2675                 2680                 2685             


Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly Ser His  Phe Phe Val 
    2690                 2695                 2700             


Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His Arg Leu  Glu Lys Val 
    2705                 2710                 2715             


Trp Asn  Arg Leu Ile Ala Arg  His Asp Met Leu Arg  Ala Val Val 
    2720                 2725                 2730             


Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln Thr Pro  Pro Trp Val 
    2735                 2740                 2745             


Ile Pro  Ala His Ile Leu His  Ser Pro Glu Glu Ala  Leu Gln Val 
    2750                 2755                 2760             


Arg Asp  Arg Leu Ala His Gln  Val Leu Asn Pro Glu  Val Trp Pro 
    2765                 2770                 2775             


Val Phe  Asp Leu Gln Val Gly  Phe Val Asp Gly Met  Pro Ala Arg 
    2780                 2785                 2790             


Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu Asp Gly  Leu Ser Met 
    2795                 2800                 2805             


Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly Tyr Arg  Tyr Pro Gln 
    2810                 2815                 2820             


Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe Arg Asp  Tyr Leu Gln 
    2825                 2830                 2835             


Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp Ser Leu  Ala Trp Trp 
    2840                 2845                 2850             


Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala Pro Ala  Leu Pro Leu 
    2855                 2860                 2865             


Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro Arg Phe  Ala Arg Leu 
    2870                 2875                 2880             


Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg Arg Leu  Lys Gln Arg 
    2885                 2890                 2895             


Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala Val Leu  Leu Ser Val 
    2900                 2905                 2910             


Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala Gln Pro  Asp Phe Thr 
    2915                 2920                 2925             


Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro Leu His  Pro Gln Ile 
    2930                 2935                 2940             


Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu Met Leu  Leu Ser Trp 
    2945                 2950                 2955             


His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala Arg Leu  Leu Gln Gln 
    2960                 2965                 2970             


Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp Val Ser  Ala Ile Arg 
    2975                 2980                 2985             


Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn Val Pro  Ala Val Pro 
    2990                 2995                 3000             


Met Pro  Val Val Phe Thr Ser  Ala Leu Gly Phe Glu  Gln Asp Asn 
    3005                 3010                 3015             


Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro Val Trp  Gly Ile Ser 
    3020                 3025                 3030             


Gln Thr  Pro Gln Val Trp Leu  Asp His Gln Val Tyr  Glu Ser Glu 
    3035                 3040                 3045             


Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val Ala Ala  Leu Phe Pro 
    3050                 3055                 3060             


Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln Tyr Cys  Ala Leu Leu 
    3065                 3070                 3075             


Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp Gln Leu  Pro Leu Ala 
    3080                 3085                 3090             


Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu Arg Arg  Ala Arg Arg 
    3095                 3100                 3105             


Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile Ala Ala  Asp Lys Ser 
    3110                 3115                 3120             


Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg Glu Val  Val Gly Glu 
    3125                 3130                 3135             


Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
    3140                 3145                 3150             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    3155                 3160                 3165             


Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Val 
    3170                 3175                 3180             


Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala Leu Glu  Glu Lys Thr 
    3185                 3190                 3195             


Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    3200                 3205                 3210             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    3215                 3220                 3225             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    3230                 3235                 3240             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    3245                 3250                 3255             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    3260                 3265                 3270             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    3275                 3280                 3285             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    3290                 3295                 3300             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    3305                 3310                 3315             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    3320                 3325                 3330             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    3335                 3340                 3345             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    3350                 3355                 3360             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    3365                 3370                 3375             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    3380                 3385                 3390             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    3395                 3400                 3405             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    3410                 3415                 3420             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    3425                 3430                 3435             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    3440                 3445                 3450             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    3455                 3460                 3465             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    3470                 3475                 3480             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    3485                 3490                 3495             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    3500                 3505                 3510             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    3515                 3520                 3525             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    3530                 3535                 3540             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    3545                 3550                 3555             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    3560                 3565                 3570             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    3575                 3580                 3585             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    3590                 3595                 3600             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    3605                 3610                 3615             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    3620                 3625                 3630             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    3635                 3640                 3645             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    3650                 3655                 3660             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    3665                 3670                 3675             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    3680                 3685                 3690             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    3695                 3700                 3705             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    3710                 3715                 3720             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    3725                 3730                 3735             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    3740                 3745                 3750             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    3755                 3760                 3765             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    3770                 3775                 3780             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    3785                 3790                 3795             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    3800                 3805                 3810             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    3815                 3820                 3825             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    3830                 3835                 3840             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    3845                 3850                 3855             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    3860                 3865                 3870             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    3875                 3880                 3885             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    3890                 3895                 3900             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    3905                 3910                 3915             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    3920                 3925                 3930             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    3935                 3940                 3945             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    3950                 3955                 3960             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    3965                 3970                 3975             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    3980                 3985                 3990             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    3995                 4000                 4005             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    4010                 4015                 4020             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    4025                 4030                 4035             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    4040                 4045                 4050             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    4055                 4060                 4065             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    4070                 4075                 4080             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    4085                 4090                 4095             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    4100                 4105                 4110             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    4115                 4120                 4125             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    4130                 4135                 4140             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    4145                 4150                 4155             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    4160                 4165                 4170             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    4175                 4180                 4185             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    4190                 4195                 4200             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    4205                 4210                 4215             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    4220                 4225                 4230             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    4235                 4240                 4245             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Thr 
    4250                 4255                 4260             


Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu 
    4265                 4270                 4275             


Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly Pro Pro  Val Glu His 
    4280                 4285                 4290             


Arg Ala  Arg Leu Val Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp 
    4295                 4300                 4305             


Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val 
    4310                 4315                 4320             


His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu 
    4325                 4330                 4335             


Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val 
    4340                 4345                 4350             


Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His 
    4355                 4360                 4365             


Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu 
    4370                 4375                 4380             


Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln 
    4385                 4390                 4395             


Thr Ala  Pro Arg Val His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp 
    4400                 4405                 4410             


Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala 
    4415                 4420                 4425             


Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu 
    4430                 4435                 4440             


Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly 
    4445                 4450                 4455             


Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp 
    4460                 4465                 4470             


Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser 
    4475                 4480                 4485             


Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr 
    4490                 4495                 4500             


Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp 
    4505                 4510                 4515             


Leu Leu  Arg Ala Gly Leu Ala  Gly 
    4520                 4525     


<210>  38
<211>  4967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IHH

<400>  38

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Pro 
    2645                 2650                 2655             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2660                 2665                 2670             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2675                 2680                 2685             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2690                 2695                 2700             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2705                 2710                 2715             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2720                 2725                 2730             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2735                 2740                 2745             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2750                 2755                 2760             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2765                 2770                 2775             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2780                 2785                 2790             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2795                 2800                 2805             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2810                 2815                 2820             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2825                 2830                 2835             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2840                 2845                 2850             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2855                 2860                 2865             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2870                 2875                 2880             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2885                 2890                 2895             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2900                 2905                 2910             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2915                 2920                 2925             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2930                 2935                 2940             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2945                 2950                 2955             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2960                 2965                 2970             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2975                 2980                 2985             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2990                 2995                 3000             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    3005                 3010                 3015             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    3020                 3025                 3030             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    3035                 3040                 3045             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    3050                 3055                 3060             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    3065                 3070                 3075             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    3080                 3085                 3090             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    3095                 3100                 3105             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    3110                 3115                 3120             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    3125                 3130                 3135             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    3140                 3145                 3150             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    3155                 3160                 3165             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    3170                 3175                 3180             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    3185                 3190                 3195             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    3200                 3205                 3210             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    3215                 3220                 3225             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    3230                 3235                 3240             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    3245                 3250                 3255             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    3260                 3265                 3270             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    3275                 3280                 3285             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    3290                 3295                 3300             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    3305                 3310                 3315             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    3320                 3325                 3330             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    3335                 3340                 3345             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    3350                 3355                 3360             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    3365                 3370                 3375             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    3380                 3385                 3390             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    3395                 3400                 3405             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    3410                 3415                 3420             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    3425                 3430                 3435             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    3440                 3445                 3450             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    3455                 3460                 3465             


Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg 
    3470                 3475                 3480             


Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala Ala Val  Asp Phe Ser 
    3485                 3490                 3495             


Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala 
    3500                 3505                 3510             


Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn 
    3515                 3520                 3525             


Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val His Pro  Leu Leu Leu 
    3530                 3535                 3540             


Ala Ala  Val Asp Val Pro Gly  His Gly Gly Ala Val  Phe Thr Gly 
    3545                 3550                 3555             


Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu Ala Glu  His Val Val 
    3560                 3565                 3570             


Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val Leu Val  Asp Leu Ala 
    3575                 3580                 3585             


Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu 
    3590                 3595                 3600             


Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu 
    3605                 3610                 3615             


Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile 
    3620                 3625                 3630             


Asp Val  His Ala Ala Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln 
    3635                 3640                 3645             


Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala 
    3650                 3655                 3660             


Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg 
    3665                 3670                 3675             


Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr 
    3680                 3685                 3690             


Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu 
    3695                 3700                 3705             


Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser 
    3710                 3715                 3720             


Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu 
    3725                 3730                 3735             


Asp Ala  Cys Phe Gln Ser Val  Gly Ala His Pro Asp  Ser Gln Ser 
    3740                 3745                 3750             


Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly Val Arg  Arg Val Arg 
    3755                 3760                 3765             


Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val 
    3770                 3775                 3780             


Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu 
    3785                 3790                 3795             


Asp Ala  His Gly Thr Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile 
    3800                 3805                 3810             


Gly Thr  Gly Val Ser Glu Arg  Asp Lys His Asn Arg  Val Leu Asn 
    3815                 3820                 3825             


Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu 
    3830                 3835                 3840             


Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys 
    3845                 3850                 3855             


Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg 
    3860                 3865                 3870             


Glu His  Ser Ala Ala Cys Thr  Thr Met Arg Trp Pro  Leu His Asp 
    3875                 3880                 3885             


Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser 
    3890                 3895                 3900             


Asp Glu  Phe Ser Gly Val Val  Val Leu Thr Gly Pro  Asn Thr Gly 
    3905                 3910                 3915             


Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg 
    3920                 3925                 3930             


Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala 
    3935                 3940                 3945             


Val Pro  Arg Met Tyr Val Val  Thr Arg Gly Ala Gln  Arg Val Leu 
    3950                 3955                 3960             


Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu 
    3965                 3970                 3975             


Leu Arg  Thr Ile Gly Ala Glu  His Pro His Leu Arg  Ala Thr Gln 
    3980                 3985                 3990             


Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln 
    3995                 4000                 4005             


Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn 
    4010                 4015                 4020             


Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln 
    4025                 4030                 4035             


Glu Arg  Arg Thr Ile Val Ala  Asp His Gln Gln Ser  Gly Met Arg 
    4040                 4045                 4050             


Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu 
    4055                 4060                 4065             


Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg 
    4070                 4075                 4080             


Val Asp  Val Arg Ala Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu 
    4085                 4090                 4095             


Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala 
    4100                 4105                 4110             


Ala Gly  Val Val Thr Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala 
    4115                 4120                 4125             


Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro 
    4130                 4135                 4140             


Ile Ala  Val Thr Asp His Arg  Leu Leu Ala Arg Val  Pro Asp Gly 
    4145                 4150                 4155             


Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr 
    4160                 4165                 4170             


Ala His  Tyr Ala Leu His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln 
    4175                 4180                 4185             


Ser Val  Leu Ile His Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala 
    4190                 4195                 4200             


Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala 
    4205                 4210                 4215             


Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp 
    4220                 4225                 4230             


Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe 
    4235                 4240                 4245             


Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp Val Val  Leu Asn Ser 
    4250                 4255                 4260             


Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu 
    4265                 4270                 4275             


Asp Gly  Val Phe Val Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala 
    4280                 4285                 4290             


Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala 
    4295                 4300                 4305             


Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu 
    4310                 4315                 4320             


Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu 
    4325                 4330                 4335             


Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro 
    4340                 4345                 4350             


Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr 
    4355                 4360                 4365             


Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu Ala Arg  His Leu Val 
    4370                 4375                 4380             


Thr Glu  His Gly Val Arg His  Leu Leu Leu Val Ser  Arg Arg Gly 
    4385                 4390                 4395             


Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp 
    4400                 4405                 4410             


Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg 
    4415                 4420                 4425             


Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr 
    4430                 4435                 4440             


Gly Val  Val His Ala Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr 
    4445                 4450                 4455             


Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val Leu Arg  Ala Lys Val 
    4460                 4465                 4470             


Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu 
    4475                 4480                 4485             


Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly 
    4490                 4495                 4500             


Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala 
    4505                 4510                 4515             


Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu 
    4520                 4525                 4530             


Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu 
    4535                 4540                 4545             


Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe 
    4550                 4555                 4560             


Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro 
    4565                 4570                 4575             


Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro 
    4580                 4585                 4590             


Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr 
    4595                 4600                 4605             


Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp 
    4610                 4615                 4620             


Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu Val Arg  Ser His Ala 
    4625                 4630                 4635             


Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg 
    4640                 4645                 4650             


Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu 
    4655                 4660                 4665             


Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser 
    4670                 4675                 4680             


Thr Leu  Val Phe Asp His Pro  Thr Pro Leu Ala Val  Ala Glu His 
    4685                 4690                 4695             


Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    4700                 4705                 4710             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    4715                 4720                 4725             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    4730                 4735                 4740             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    4745                 4750                 4755             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    4760                 4765                 4770             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    4775                 4780                 4785             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    4790                 4795                 4800             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    4805                 4810                 4815             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    4820                 4825                 4830             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    4835                 4840                 4845             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    4850                 4855                 4860             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    4865                 4870                 4875             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    4880                 4885                 4890             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    4895                 4900                 4905             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    4910                 4915                 4920             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    4925                 4930                 4935             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    4940                 4945                 4950             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    4955                 4960                 4965         


<210>  39
<211>  4416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IHO

<400>  39

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Pro 
    2645                 2650                 2655             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2660                 2665                 2670             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2675                 2680                 2685             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2690                 2695                 2700             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2705                 2710                 2715             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2720                 2725                 2730             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2735                 2740                 2745             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2750                 2755                 2760             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2765                 2770                 2775             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2780                 2785                 2790             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2795                 2800                 2805             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2810                 2815                 2820             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2825                 2830                 2835             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2840                 2845                 2850             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2855                 2860                 2865             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2870                 2875                 2880             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2885                 2890                 2895             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2900                 2905                 2910             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2915                 2920                 2925             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2930                 2935                 2940             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2945                 2950                 2955             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2960                 2965                 2970             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2975                 2980                 2985             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2990                 2995                 3000             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    3005                 3010                 3015             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    3020                 3025                 3030             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    3035                 3040                 3045             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    3050                 3055                 3060             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    3065                 3070                 3075             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    3080                 3085                 3090             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    3095                 3100                 3105             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    3110                 3115                 3120             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    3125                 3130                 3135             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    3140                 3145                 3150             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    3155                 3160                 3165             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    3170                 3175                 3180             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    3185                 3190                 3195             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    3200                 3205                 3210             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    3215                 3220                 3225             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    3230                 3235                 3240             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    3245                 3250                 3255             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    3260                 3265                 3270             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    3275                 3280                 3285             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    3290                 3295                 3300             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    3305                 3310                 3315             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    3320                 3325                 3330             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    3335                 3340                 3345             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    3350                 3355                 3360             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    3365                 3370                 3375             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    3380                 3385                 3390             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    3395                 3400                 3405             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    3410                 3415                 3420             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    3425                 3430                 3435             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    3440                 3445                 3450             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    3455                 3460                 3465             


Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr 
    3470                 3475                 3480             


Val Leu  Gly His Leu Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His 
    3485                 3490                 3495             


Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln 
    3500                 3505                 3510             


Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp 
    3515                 3520                 3525             


Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly 
    3530                 3535                 3540             


Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp 
    3545                 3550                 3555             


Gln His  Thr Leu Gln Val Leu  Thr Lys Leu Ala Ala  Gln His Asn 
    3560                 3565                 3570             


Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile 
    3575                 3580                 3585             


Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp 
    3590                 3595                 3600             


Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp Asp Ala  Asp Ala Val 
    3605                 3610                 3615             


Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln 
    3620                 3625                 3630             


Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala 
    3635                 3640                 3645             


Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile 
    3650                 3655                 3660             


Val His  Val Ala Ala Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg 
    3665                 3670                 3675             


Ser Leu  Leu Arg Met Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg 
    3680                 3685                 3690             


Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp 
    3695                 3700                 3705             


Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val 
    3710                 3715                 3720             


Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser 
    3725                 3730                 3735             


Leu Glu  Leu Pro His Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu 
    3740                 3745                 3750             


Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg 
    3755                 3760                 3765             


Ile Ala  Ala Pro His Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala 
    3770                 3775                 3780             


Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser 
    3785                 3790                 3795             


Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr 
    3800                 3805                 3810             


Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala 
    3815                 3820                 3825             


Arg His  Leu Val Thr Glu His  Gly Val Arg His Leu  Leu Leu Val 
    3830                 3835                 3840             


Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala 
    3845                 3850                 3855             


Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp 
    3860                 3865                 3870             


Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro 
    3875                 3880                 3885             


Arg Pro  Leu Thr Gly Val Val  His Ala Ala Gly Val  Leu Ala Asp 
    3890                 3895                 3900             


Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu 
    3905                 3910                 3915             


Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala 
    3920                 3925                 3930             


Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser 
    3935                 3940                 3945             


Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu 
    3950                 3955                 3960             


Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro 
    3965                 3970                 3975             


Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile 
    3980                 3985                 3990             


Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly 
    3995                 4000                 4005             


Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser 
    4010                 4015                 4020             


Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala 
    4025                 4030                 4035             


Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn 
    4040                 4045                 4050             


Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro 
    4055                 4060                 4065             


Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val 
    4070                 4075                 4080             


Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln 
    4085                 4090                 4095             


Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu 
    4100                 4105                 4110             


Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val 
    4115                 4120                 4125             


Arg Leu  Pro Ser Thr Leu Val  Phe Asp His Pro Thr  Pro Leu Ala 
    4130                 4135                 4140             


Val Ala  Glu His Leu Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn 
    4145                 4150                 4155             


Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp 
    4160                 4165                 4170             


Leu Arg  Arg Phe Gly Pro Pro  Val Glu His Arg Ala  Arg Leu Val 
    4175                 4180                 4185             


Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu 
    4190                 4195                 4200             


Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val His Ala  Val Gln Tyr 
    4205                 4210                 4215             


Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala 
    4220                 4225                 4230             


Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly 
    4235                 4240                 4245             


Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His Ser Met  Gly Ala Leu 
    4250                 4255                 4260             


Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly 
    4265                 4270                 4275             


Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val 
    4280                 4285                 4290             


His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp 
    4295                 4300                 4305             


Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu 
    4310                 4315                 4320             


Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg 
    4325                 4330                 4335             


Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala 
    4340                 4345                 4350             


Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr 
    4355                 4360                 4365             


Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser Val Ile  Pro Gly Arg 
    4370                 4375                 4380             


Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val 
    4385                 4390                 4395             


Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly 
    4400                 4405                 4410             


Leu Ala  Gly 
    4415     


<210>  40
<211>  4529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IHS

<400>  40

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Leu 
    2645                 2650                 2655             


Pro Val  Glu Gln Pro Phe Val  His Ser Pro Glu Glu  Arg Tyr Arg 
    2660                 2665                 2670             


Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala Tyr Leu  Val Gly Arg 
    2675                 2680                 2685             


Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly Ser His  Phe Phe Val 
    2690                 2695                 2700             


Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His Arg Leu  Glu Lys Val 
    2705                 2710                 2715             


Trp Asn  Arg Leu Ile Ala Arg  His Asp Met Leu Arg  Ala Val Val 
    2720                 2725                 2730             


Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln Thr Pro  Pro Trp Val 
    2735                 2740                 2745             


Ile Pro  Ala His Ile Leu His  Ser Pro Glu Glu Ala  Leu Gln Val 
    2750                 2755                 2760             


Arg Asp  Arg Leu Ala His Gln  Val Leu Asn Pro Glu  Val Trp Pro 
    2765                 2770                 2775             


Val Phe  Asp Leu Gln Val Gly  Phe Val Asp Gly Met  Pro Ala Arg 
    2780                 2785                 2790             


Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu Asp Gly  Leu Ser Met 
    2795                 2800                 2805             


Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly Tyr Arg  Tyr Pro Gln 
    2810                 2815                 2820             


Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe Arg Asp  Tyr Leu Gln 
    2825                 2830                 2835             


Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp Ser Leu  Ala Trp Trp 
    2840                 2845                 2850             


Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala Pro Ala  Leu Pro Leu 
    2855                 2860                 2865             


Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro Arg Phe  Ala Arg Leu 
    2870                 2875                 2880             


Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg Arg Leu  Lys Gln Arg 
    2885                 2890                 2895             


Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala Val Leu  Leu Ser Val 
    2900                 2905                 2910             


Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala Gln Pro  Asp Phe Thr 
    2915                 2920                 2925             


Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro Leu His  Pro Gln Ile 
    2930                 2935                 2940             


Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu Met Leu  Leu Ser Trp 
    2945                 2950                 2955             


His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala Arg Leu  Leu Gln Gln 
    2960                 2965                 2970             


Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp Val Ser  Ala Ile Arg 
    2975                 2980                 2985             


Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn Val Pro  Ala Val Pro 
    2990                 2995                 3000             


Met Pro  Val Val Phe Thr Ser  Ala Leu Gly Phe Glu  Gln Asp Asn 
    3005                 3010                 3015             


Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro Val Trp  Gly Ile Ser 
    3020                 3025                 3030             


Gln Thr  Pro Gln Val Trp Leu  Asp His Gln Val Tyr  Glu Ser Glu 
    3035                 3040                 3045             


Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val Ala Ala  Leu Phe Pro 
    3050                 3055                 3060             


Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln Tyr Cys  Ala Leu Leu 
    3065                 3070                 3075             


Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp Gln Leu  Pro Leu Ala 
    3080                 3085                 3090             


Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu Arg Arg  Ala Arg Arg 
    3095                 3100                 3105             


Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile Ala Ala  Asp Lys Ser 
    3110                 3115                 3120             


Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg Glu Val  Val Gly Glu 
    3125                 3130                 3135             


Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
    3140                 3145                 3150             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    3155                 3160                 3165             


Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Val 
    3170                 3175                 3180             


Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala Leu Glu  Glu Lys Thr 
    3185                 3190                 3195             


Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    3200                 3205                 3210             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    3215                 3220                 3225             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    3230                 3235                 3240             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    3245                 3250                 3255             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    3260                 3265                 3270             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    3275                 3280                 3285             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    3290                 3295                 3300             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    3305                 3310                 3315             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    3320                 3325                 3330             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    3335                 3340                 3345             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    3350                 3355                 3360             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    3365                 3370                 3375             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    3380                 3385                 3390             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    3395                 3400                 3405             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    3410                 3415                 3420             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    3425                 3430                 3435             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    3440                 3445                 3450             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    3455                 3460                 3465             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    3470                 3475                 3480             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    3485                 3490                 3495             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    3500                 3505                 3510             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    3515                 3520                 3525             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    3530                 3535                 3540             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    3545                 3550                 3555             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    3560                 3565                 3570             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    3575                 3580                 3585             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    3590                 3595                 3600             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    3605                 3610                 3615             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    3620                 3625                 3630             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    3635                 3640                 3645             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    3650                 3655                 3660             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    3665                 3670                 3675             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    3680                 3685                 3690             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    3695                 3700                 3705             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    3710                 3715                 3720             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    3725                 3730                 3735             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    3740                 3745                 3750             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    3755                 3760                 3765             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    3770                 3775                 3780             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    3785                 3790                 3795             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    3800                 3805                 3810             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    3815                 3820                 3825             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    3830                 3835                 3840             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    3845                 3850                 3855             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    3860                 3865                 3870             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    3875                 3880                 3885             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    3890                 3895                 3900             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    3905                 3910                 3915             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    3920                 3925                 3930             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    3935                 3940                 3945             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    3950                 3955                 3960             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    3965                 3970                 3975             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    3980                 3985                 3990             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    3995                 4000                 4005             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    4010                 4015                 4020             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    4025                 4030                 4035             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    4040                 4045                 4050             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    4055                 4060                 4065             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    4070                 4075                 4080             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    4085                 4090                 4095             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    4100                 4105                 4110             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    4115                 4120                 4125             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    4130                 4135                 4140             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    4145                 4150                 4155             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    4160                 4165                 4170             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    4175                 4180                 4185             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    4190                 4195                 4200             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    4205                 4210                 4215             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    4220                 4225                 4230             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    4235                 4240                 4245             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    4250                 4255                 4260             


Pro Ile  Thr Ser Gly Glu Asp  Asn Pro Ile Pro Leu  Cys Gln Gly 
    4265                 4270                 4275             


Asp Gly  Glu Glu Met Ser Thr  Trp Leu Arg Arg Phe  Gly Pro Pro 
    4280                 4285                 4290             


Val Glu  His Arg Ala Arg Leu  Val Cys Phe Pro His  Ala Gly Ala 
    4295                 4300                 4305             


Ala Ala  Asp Ser Tyr Leu Asp  Leu Ala Arg Ala Leu  Ala Pro Glu 
    4310                 4315                 4320             


Ile Asp  Val His Ala Val Gln  Tyr Pro Gly Arg Gln  Asp Arg Arg 
    4325                 4330                 4335             


Asp Glu  Glu Pro Leu Gly Thr  Ala Gly Glu Ile Ala  Asp Glu Val 
    4340                 4345                 4350             


Ala Ala  Val Leu Arg Ala Ser  Gly Gly Asp Gly Pro  Phe Ala Leu 
    4355                 4360                 4365             


Phe Gly  His Ser Met Gly Ala  Leu Ile Ala Tyr Glu  Thr Ala Arg 
    4370                 4375                 4380             


Arg Leu  Glu Arg Glu Pro Gly  Gly Gly Pro Leu Arg  Leu Phe Val 
    4385                 4390                 4395             


Ser Gly  Gln Thr Ala Pro Arg  Val His Glu Arg Arg  Thr Asp Leu 
    4400                 4405                 4410             


Pro Gly  Asp Asp Gly Leu Val  Asp Glu Leu Arg Arg  Leu Gly Thr 
    4415                 4420                 4425             


Ser Glu  Ala Ala Leu Ala Asp  Glu Ala Leu Leu Ala  Met Ser Leu 
    4430                 4435                 4440             


Pro Val  Leu Arg Ala Asp Tyr  Arg Val Leu Arg Ser  Tyr Ala Trp 
    4445                 4450                 4455             


Ala Asp  Gly Pro Pro Leu Arg  Ala Gly Ile Thr Ala  Leu Cys Gly 
    4460                 4465                 4470             


Asp Ala  Asp Pro Leu Thr Ala  Thr Gly Asp Ala Glu  Arg Trp Leu 
    4475                 4480                 4485             


Gln His  Ser Val Ile Pro Gly  Arg Thr Arg Thr Phe  Pro Gly Gly 
    4490                 4495                 4500             


His Phe  Tyr Leu Gly Glu Gln  Val Thr Glu Val Ala  Gly Ala Val 
    4505                 4510                 4515             


Arg Arg  Asp Leu Leu Arg Ala  Gly Leu Ala Gly 
    4520                 4525                 


<210>  41
<211>  3975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOC

<400>  41

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Leu Pro Val Glu  Gln Pro Phe Val His  Ser Pro Glu 
    2105                 2110                 2115             


Glu Arg  Tyr Arg Pro Phe Ala  Leu Thr Asp Val Gln  Gln Ala Tyr 
    2120                 2125                 2130             


Leu Val  Gly Arg Gln Pro Gly  Phe Ala Leu Gly Gly  Val Gly Ser 
    2135                 2140                 2145             


His Phe  Phe Val Glu Phe Glu  Ile Ala Asp Leu Asp  Ile His Arg 
    2150                 2155                 2160             


Leu Glu  Lys Val Trp Asn Arg  Leu Ile Ala Arg His  Asp Met Leu 
    2165                 2170                 2175             


Arg Ala  Val Val Arg Asp Gly  Gln Gln Arg Val Leu  Glu Gln Thr 
    2180                 2185                 2190             


Pro Pro  Trp Val Ile Pro Ala  His Ile Leu His Ser  Pro Glu Glu 
    2195                 2200                 2205             


Ala Leu  Gln Val Arg Asp Arg  Leu Ala His Gln Val  Leu Asn Pro 
    2210                 2215                 2220             


Glu Val  Trp Pro Val Phe Asp  Leu Gln Val Gly Phe  Val Asp Gly 
    2225                 2230                 2235             


Met Pro  Ala Arg Leu Trp Leu  Cys Leu Asp Asn Leu  Leu Leu Asp 
    2240                 2245                 2250             


Gly Leu  Ser Met Gln Ile Leu  Leu Ser Glu Leu Glu  His Gly Tyr 
    2255                 2260                 2265             


Arg Tyr  Pro Gln Gln Leu Pro  Pro Pro Leu Pro Ile  Thr Phe Arg 
    2270                 2275                 2280             


Asp Tyr  Leu Gln Gln Pro Ala  Leu Arg Thr Pro Asn  Pro Asp Ser 
    2285                 2290                 2295             


Leu Ala  Trp Trp Gln Thr Gln  Leu Asp Asp Ile Pro  Pro Ala Pro 
    2300                 2305                 2310             


Ala Leu  Pro Leu Arg Cys Leu  Pro Gln Asp Val Glu  Thr Pro Arg 
    2315                 2320                 2325             


Phe Ala  Arg Leu Tyr Gly Ala  Met Asp Ser Ala Arg  Trp Arg Arg 
    2330                 2335                 2340             


Leu Lys  Gln Arg Ala Ala Asp  Ala His Leu Thr Pro  Ser Ala Val 
    2345                 2350                 2355             


Leu Leu  Ser Val Trp Ser Thr  Val Leu Ala Ala Trp  Ser Ala Gln 
    2360                 2365                 2370             


Pro Asp  Phe Thr Leu Asn Leu  Thr Leu Phe Asp Arg  Arg Pro Leu 
    2375                 2380                 2385             


His Pro  Gln Ile Asn Gln Ile  Leu Gly Asp Phe Thr  Ser Leu Met 
    2390                 2395                 2400             


Leu Leu  Ser Trp His Pro Gly  Glu Ser Trp Leu Gln  Ser Ala Arg 
    2405                 2410                 2415             


Leu Leu  Gln Gln Arg Leu Ser  Glu Ser Leu Asn His  Arg Asp Val 
    2420                 2425                 2430             


Ser Ala  Ile Arg Val Met Arg  Gln Leu Ala Arg Arg  Gln Asn Val 
    2435                 2440                 2445             


Pro Ala  Val Pro Met Pro Val  Val Phe Thr Ser Ala  Leu Gly Phe 
    2450                 2455                 2460             


Glu Gln  Asp Asn Phe Leu Ala  Arg Arg Asn Leu Leu  Lys Pro Val 
    2465                 2470                 2475             


Trp Gly  Ile Ser Gln Thr Pro  Gln Val Trp Leu Asp  His Gln Val 
    2480                 2485                 2490             


Tyr Glu  Ser Glu Gly Glu Leu  Arg Phe Asn Trp Asp  Phe Val Ala 
    2495                 2500                 2505             


Ala Leu  Phe Pro Asp Gly Gln  Val Glu Arg Gln Phe  Ala Gln Tyr 
    2510                 2515                 2520             


Cys Ala  Leu Leu Asn Arg Met  Ala Glu Asp Asp Ser  Ser Trp Gln 
    2525                 2530                 2535             


Leu Pro  Leu Ala Asp Leu Val  Pro Pro Leu Lys Val  Thr Glu Arg 
    2540                 2545                 2550             


Arg Ala  Arg Arg Leu Arg Pro  Glu Arg Ala Gln Pro  Arg Ile Ala 
    2555                 2560                 2565             


Ala Asp  Lys Ser Ser Val Ser  Leu Ile Cys Asp Thr  Phe Arg Glu 
    2570                 2575                 2580             


Val Val  Gly Glu Pro Val Ala  Pro Ala Glu Asn Phe  Phe Glu Ala 
    2585                 2590                 2595             


Gly Ala  Thr Ser Leu Asn Leu  Val Gln Leu His Val  Leu Leu Gln 
    2600                 2605                 2610             


Arg His  Glu Phe Ala Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His 
    2615                 2620                 2625             


Pro Ser  Pro Val Ala Leu Ala  Asn Tyr Leu Ala Gly  Val Ala Leu 
    2630                 2635                 2640             


Glu Glu  Lys Thr Lys Arg Val  Arg Pro Val Arg Arg  Arg Gln Arg 
    2645                 2650                 2655             


Arg Ile  Gly Glu Pro Phe Pro  Leu Ala Pro Met Gln  His Ala Met 
    2660                 2665                 2670             


Trp Val  Gly Arg His Asp His  Gln Gln Leu Gly Gly  Val Ala Gly 
    2675                 2680                 2685             


His Leu  Tyr Val Glu Phe Asp  Gly Ala Arg Val Asp  Pro Asp Arg 
    2690                 2695                 2700             


Leu Arg  Ala Ala Ala Thr Arg  Leu Ala Leu Arg His  Pro Met Leu 
    2705                 2710                 2715             


Arg Val  Gln Phe Leu Pro Asp  Gly Thr Gln Arg Ile  Pro Pro Ala 
    2720                 2725                 2730             


Ala Gly  Ser Arg Asp Phe Pro  Ile Ser Val Ala Asp  Leu Arg His 
    2735                 2740                 2745             


Val Ala  Pro Asp Val Val Asp  Gln Arg Leu Ala Gly  Ile Arg Asp 
    2750                 2755                 2760             


Ala Lys  Ser His Gln Gln Leu  Asp Gly Ala Val Phe  Glu Leu Ala 
    2765                 2770                 2775             


Leu Thr  Leu Leu Pro Gly Glu  Arg Thr Arg Leu His  Val Asp Leu 
    2780                 2785                 2790             


Asp Met  Gln Ala Ala Asp Ala  Met Ser Tyr Arg Ile  Leu Leu Ala 
    2795                 2800                 2805             


Asp Leu  Ala Ala Leu Tyr Asp  Gly Arg Glu Pro Pro  Ala Leu Gly 
    2810                 2815                 2820             


Tyr Thr  Tyr Arg Glu Tyr Arg  Gln Ala Ile Glu Ala  Glu Glu Thr 
    2825                 2830                 2835             


Leu Pro  Gln Pro Val Arg Asp  Ala Asp Arg Asp Trp  Trp Ala Gln 
    2840                 2845                 2850             


Arg Ile  Pro Gln Leu Pro Asp  Pro Pro Ala Leu Pro  Thr Arg Ala 
    2855                 2860                 2865             


Gly Gly  Glu Arg Asp Arg Arg  Arg Ser Thr Arg Arg  Trp His Trp 
    2870                 2875                 2880             


Leu Asp  Pro Gln Thr Arg Asp  Ala Leu Phe Ala Arg  Ala Arg Ala 
    2885                 2890                 2895             


Arg Gly  Ile Thr Pro Ala Met  Thr Leu Ala Ala Ala  Phe Ala Asn 
    2900                 2905                 2910             


Val Leu  Ala Arg Trp Ser Ala  Ser Ser Arg Phe Leu  Leu Asn Leu 
    2915                 2920                 2925             


Pro Leu  Phe Ser Arg Gln Ala  Leu His Pro Asp Val  Asp Leu Leu 
    2930                 2935                 2940             


Val Gly  Asp Phe Thr Ser Ser  Leu Leu Leu Asp Val  Asp Leu Gly 
    2945                 2950                 2955             


Asp Thr  Val Ser Asn Leu Ala  Arg Lys Asn Gln Leu  Thr Phe Thr 
    2960                 2965                 2970             


Glu Asp  Trp Glu His Arg His  Trp Ser Gly Val Glu  Leu Leu Arg 
    2975                 2980                 2985             


Glu Leu  Lys Arg Gln Gln Arg  Tyr Pro His Gly Ala  Pro Val Val 
    2990                 2995                 3000             


Phe Thr  Ser Asn Leu Gly Arg  Ser Leu Tyr Ser Ser  Arg Ala Glu 
    3005                 3010                 3015             


Ser Pro  Leu Gly Glu Pro Glu  Trp Gly Ile Ser Gln  Thr Pro Gln 
    3020                 3025                 3030             


Val Trp  Ile Asp His Leu Ala  Phe Glu His His Gly  Glu Val Trp 
    3035                 3040                 3045             


Leu Gln  Trp Asp Ser Asn Asp  Ala Leu Phe Pro Pro  Ala Leu Val 
    3050                 3055                 3060             


Glu Thr  Leu Phe Asp Ala Tyr  Cys Gln Leu Ile Asn  Gln Leu Cys 
    3065                 3070                 3075             


Asp Asp  Glu Ser Ala Trp Gln  Lys Pro Phe Ala Asp  Met Met Pro 
    3080                 3085                 3090             


Ala Ser  Gln Arg Ala Ile Arg  Glu Arg Val Asn Ala  Thr Gly Ala 
    3095                 3100                 3105             


Pro Ile  Pro Glu Gly Leu Leu  His Glu Gly Ile Phe  Arg Ile Ala 
    3110                 3115                 3120             


Leu Gln  Gln Pro Gln Ala Leu  Ala Val Thr Asp Met  Arg Tyr Gln 
    3125                 3130                 3135             


Trp Asn  Ser Tyr Arg Glu Met  Arg Glu Gln Val Val  Ala Leu Ala 
    3140                 3145                 3150             


Asn Leu  Leu Arg Glu Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala 
    3155                 3160                 3165             


Val Ala  Leu Pro Arg Ser Val  Phe Leu Thr Leu Ala  Leu His Ala 
    3170                 3175                 3180             


Ile Val  Glu Ala Gly Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr 
    3185                 3190                 3195             


Pro Asp  Asp Arg Leu Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser 
    3200                 3205                 3210             


Leu Leu  Ile Thr Thr Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val 
    3215                 3220                 3225             


Pro Asn  Leu Thr Ser Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln 
    3230                 3235                 3240             


Gly Ser  Ala Pro Leu Gln Leu  Ser Gln Pro His His  Thr Ala Tyr 
    3245                 3250                 3255             


Ile Ile  Phe Thr Ser Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met 
    3260                 3265                 3270             


Val Gly  Gln Thr Ala Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn 
    3275                 3280                 3285             


His Tyr  Pro Leu Thr Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro 
    3290                 3295                 3300             


Cys Ser  Phe Asp Val Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile 
    3305                 3310                 3315             


Ala Gly  Ala Lys Leu Val Met  Ala Glu Pro Glu Ala  His Arg Asp 
    3320                 3325                 3330             


Pro Leu  Ala Met Gln Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr 
    3335                 3340                 3345             


Thr His  Phe Val Pro Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu 
    3350                 3355                 3360             


Thr Pro  Gln Thr Ala Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val 
    3365                 3370                 3375             


Phe Cys  Ser Gly Glu Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp 
    3380                 3385                 3390             


Gln Gln  Leu Thr Gly Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr 
    3395                 3400                 3405             


Glu Ala  Ala Val Asp Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu 
    3410                 3415                 3420             


Leu Ala  Gln Val Arg Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val 
    3425                 3430                 3435             


Trp Asn  Thr Gly Leu Arg Ile  Leu Asp Ala Met Met  His Pro Val 
    3440                 3445                 3450             


Pro Pro  Gly Val Ala Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu 
    3455                 3460                 3465             


Ala Gln  Gly Tyr Leu Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe 
    3470                 3475                 3480             


Ile Ala  Asp Pro Phe Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly 
    3485                 3490                 3495             


Asp Val  Ala Arg Trp Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly 
    3500                 3505                 3510             


Arg Ser  Asp Asp Gln Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu 
    3515                 3520                 3525             


Gly Glu  Ile Asp Arg Val Met  Gln Ala Leu Pro Asp  Val Glu Gln 
    3530                 3535                 3540             


Ala Val  Ala Ser Cys Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn 
    3545                 3550                 3555             


Lys His  Leu Val Ala Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys 
    3560                 3565                 3570             


Thr Glu  Arg Ser Arg Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser 
    3575                 3580                 3585             


Phe Leu  Lys Glu Lys Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile 
    3590                 3595                 3600             


Val Ile  Leu Asp Ala Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp 
    3605                 3610                 3615             


Arg Arg  Ala Leu Pro Ala Pro  Asp Leu His Ser Gln  Leu Leu Asp 
    3620                 3625                 3630             


Lys Tyr  Val Ala Pro Arg Asn  Pro Ile Glu Thr Ile  Ile Ala Ala 
    3635                 3640                 3645             


Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val Gln Asp  Ala Asp Ala 
    3650                 3655                 3660             


Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu Leu Ala  Met Lys Leu 
    3665                 3670                 3675             


Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg Gln Val  Thr Pro Gly 
    3680                 3685                 3690             


Gln Val  Met Val Ala Ser Thr  Val Ala Lys Leu Ala  Thr Ile Ile 
    3695                 3700                 3705             


Asp Ala  Glu Thr Ser Gly Glu  Asp Asn Pro Ile Pro  Leu Cys Gln 
    3710                 3715                 3720             


Gly Asp  Gly Glu Glu Met Ser  Thr Trp Leu Arg Arg  Phe Gly Pro 
    3725                 3730                 3735             


Pro Val  Glu His Arg Ala Arg  Leu Val Cys Phe Pro  His Ala Gly 
    3740                 3745                 3750             


Ala Ala  Ala Asp Ser Tyr Leu  Asp Leu Ala Arg Ala  Leu Ala Pro 
    3755                 3760                 3765             


Glu Ile  Asp Val His Ala Val  Gln Tyr Pro Gly Arg  Gln Asp Arg 
    3770                 3775                 3780             


Arg Asp  Glu Glu Pro Leu Gly  Thr Ala Gly Glu Ile  Ala Asp Glu 
    3785                 3790                 3795             


Val Ala  Ala Val Leu Arg Ala  Ser Gly Gly Asp Gly  Pro Phe Ala 
    3800                 3805                 3810             


Leu Phe  Gly His Ser Met Gly  Ala Leu Ile Ala Tyr  Glu Thr Ala 
    3815                 3820                 3825             


Arg Arg  Leu Glu Arg Glu Pro  Gly Gly Gly Pro Leu  Arg Leu Phe 
    3830                 3835                 3840             


Val Ser  Gly Gln Thr Ala Pro  Arg Val His Glu Arg  Arg Thr Asp 
    3845                 3850                 3855             


Leu Pro  Gly Asp Asp Gly Leu  Val Asp Glu Leu Arg  Arg Leu Gly 
    3860                 3865                 3870             


Thr Ser  Glu Ala Ala Leu Ala  Asp Glu Ala Leu Leu  Ala Met Ser 
    3875                 3880                 3885             


Leu Pro  Val Leu Arg Ala Asp  Tyr Arg Val Leu Arg  Ser Tyr Ala 
    3890                 3895                 3900             


Trp Ala  Asp Gly Pro Pro Leu  Arg Ala Gly Ile Thr  Ala Leu Cys 
    3905                 3910                 3915             


Gly Asp  Ala Asp Pro Leu Thr  Ala Thr Gly Asp Ala  Glu Arg Trp 
    3920                 3925                 3930             


Leu Gln  His Ser Val Ile Pro  Gly Arg Thr Arg Thr  Phe Pro Gly 
    3935                 3940                 3945             


Gly His  Phe Tyr Leu Gly Glu  Gln Val Thr Glu Val  Ala Gly Ala 
    3950                 3955                 3960             


Val Arg  Arg Asp Leu Leu Arg  Ala Gly Leu Ala Gly  
    3965                 3970                 3975 


<210>  42
<211>  4416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOH

<400>  42

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Pro Gly Ile Gly  Ala Leu Val Pro Ala  Pro Val Val 
    2105                 2110                 2115             


Ile Ala  Ala Gly Arg Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met 
    2120                 2125                 2130             


Ala Cys  Arg Leu Pro Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp 
    2135                 2140                 2145             


Glu Leu  Leu Arg Glu Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr 
    2150                 2155                 2160             


Asp Arg  Gly Trp Asp Leu Ala  Arg Leu His His Pro  Asp Pro Asp 
    2165                 2170                 2175             


Asn Pro  Gly Thr Ser Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp 
    2180                 2185                 2190             


Ala Ala  Gly Phe Asp Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu 
    2195                 2200                 2205             


Ala Ala  Ala Met Asp Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser 
    2210                 2215                 2220             


Trp Glu  Leu Val Glu Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg 
    2225                 2230                 2235             


Gly Thr  Ala Thr Gly Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr 
    2240                 2245                 2250             


Gly Glu  Asp Thr Ala Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val 
    2255                 2260                 2265             


Thr Gly  Val Ala Pro Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr 
    2270                 2275                 2280             


Met Gly  Leu Glu Gly Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser 
    2285                 2290                 2295             


Ser Ser  Leu Val Ala Leu His  Leu Ala Val Glu Ser  Leu Arg Lys 
    2300                 2305                 2310             


Gly Glu  Ser Ser Met Ala Val  Val Gly Gly Ala Ala  Val Met Ala 
    2315                 2320                 2325             


Thr Pro  Gly Val Phe Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala 
    2330                 2335                 2340             


Ala Asp  Gly Arg Ser Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe 
    2345                 2350                 2355             


Gly Phe  Ser Glu Gly Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser 
    2360                 2365                 2370             


Glu Ala  Arg Arg Asn Gly His  Glu Val Leu Ala Val  Val Arg Gly 
    2375                 2380                 2385             


Ser Ala  Leu Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro 
    2390                 2395                 2400             


Ser Gly  Pro Ala Gln Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser 
    2405                 2410                 2415             


Cys Gly  Leu Glu Pro Gly Asp  Val Asp Ala Val Glu  Ala His Gly 
    2420                 2425                 2430             


Thr Gly  Thr Ala Leu Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu 
    2435                 2440                 2445             


Asp Thr  Tyr Gly Arg Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu 
    2450                 2455                 2460             


Gly Ser  Val Lys Ser Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly 
    2465                 2470                 2475             


Val Thr  Gly Leu Leu Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu 
    2480                 2485                 2490             


Leu Pro  Ala Thr Leu His Val  Glu Glu Pro Thr Pro  His Val Asp 
    2495                 2500                 2505             


Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp 
    2510                 2515                 2520             


Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly 
    2525                 2530                 2535             


Ile Ser  Gly Thr Asn Ala His  Val Ile Val Glu Glu  Ala Pro Gln 
    2540                 2545                 2550             


Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser 
    2555                 2560                 2565             


Thr Leu  Val Val Ala Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr 
    2570                 2575                 2580             


Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val 
    2585                 2590                 2595             


Ala Leu  Ala Asp Val Ala His  Thr Leu Asn His His  Arg Ser Arg 
    2600                 2605                 2610             


Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala 
    2615                 2620                 2625             


Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly 
    2630                 2635                 2640             


Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe 
    2645                 2650                 2655             


Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu 
    2660                 2665                 2670             


Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg Ile His  Gln Gln Val 
    2675                 2680                 2685             


Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly 
    2690                 2695                 2700             


Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly 
    2705                 2710                 2715             


Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp Ala Val  Val Gly His 
    2720                 2725                 2730             


Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser 
    2735                 2740                 2745             


Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met 
    2750                 2755                 2760             


Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala Ala Val  Pro Val Ser 
    2765                 2770                 2775             


Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala 
    2780                 2785                 2790             


Ala Val  Asn Gly Pro Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala 
    2795                 2800                 2805             


Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu 
    2810                 2815                 2820             


Pro Thr  Ser His Ala Phe His  Ser Ala Arg Met Glu  Pro Met Leu 
    2825                 2830                 2835             


Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro 
    2840                 2845                 2850             


Gln Val  Ala Met Ala Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr 
    2855                 2860                 2865             


Trp Val  Arg Gln Val Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val 
    2870                 2875                 2880             


Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg 
    2885                 2890                 2895             


Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala Met Leu  His Gly Asp 
    2900                 2905                 2910             


His Glu  Ala Gln Ala Gly Met  Arg Arg Glu Gln Pro  Leu Pro Leu 
    2915                 2920                 2925             


Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His Asn Ala  Gly Ala Ala 
    2930                 2935                 2940             


Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly Arg Leu  Val Asp Ala 
    2945                 2950                 2955             


Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu Phe Tyr  Asp Arg Glu 
    2960                 2965                 2970             


Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser Thr Val  Ala Val His 
    2975                 2980                 2985             


Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro Gly His  Gly Gly Ala 
    2990                 2995                 3000             


Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu Gln Pro  Trp Leu Ala 
    3005                 3010                 3015             


Glu His  Val Val Gly Gly Arg  Thr Leu Val Pro Gly  Ser Val Leu 
    3020                 3025                 3030             


Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp Val Gly  Leu Pro Val 
    3035                 3040                 3045             


Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu Val Leu  Ala Gly Ala 
    3050                 3055                 3060             


Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala Pro Asp  Glu Ser Gly 
    3065                 3070                 3075             


Arg Arg  Thr Ile Asp Val His  Ala Ala Glu Asp Val  Ala Asp Leu 
    3080                 3085                 3090             


Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr Gly Thr  Leu Ala Gln 
    3095                 3100                 3105             


Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu Gln Trp  Pro Pro Glu 
    3110                 3115                 3120             


Asp Ala  Val Arg Ile Pro Leu  Asp Asp His Tyr Asp  Gly Leu Ala 
    3125                 3130                 3135             


Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe Gln Ala  Leu Val Ala 
    3140                 3145                 3150             


Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met Leu Ala  Glu Val Ala 
    3155                 3160                 3165             


Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly Leu Tyr  Ala Ile His 
    3170                 3175                 3180             


Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser Val Gly  Ala His Pro 
    3185                 3190                 3195             


Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu Val Pro  Leu Gly Val 
    3200                 3205                 3210             


Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg Thr Ala  Arg Tyr Cys 
    3215                 3220                 3225             


Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala Gly Val  Glu Ala Asp 
    3230                 3235                 3240             


Ile Asp  Val Leu Asp Ala His  Gly Thr Val Leu Leu  Ala Val Cys 
    3245                 3250                 3255             


Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu Arg Asp  Lys His Asn 
    3260                 3265                 3270             


Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile Glu Trp  His Gln Arg 
    3275                 3280                 3285             


Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala Gly Lys  Trp Leu Leu 
    3290                 3295                 3300             


Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr Ala Thr  Arg Leu Ala 
    3305                 3310                 3315             


Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys Thr Thr  Met Arg Trp 
    3320                 3325                 3330             


Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala Asp Gln  Leu Arg Asp 
    3335                 3340                 3345             


Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val Val Val  Leu Thr Gly 
    3350                 3355                 3360             


Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser Ala Asp  Arg Gly Ala 
    3365                 3370                 3375             


Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala Arg Glu  Leu Ser Asp 
    3380                 3385                 3390             


Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val Val Thr  Arg Gly Ala 
    3395                 3400                 3405             


Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn Leu Glu  Gln Gly Gly 
    3410                 3415                 3420             


Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala Glu His  Pro His Leu 
    3425                 3430                 3435             


Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln Thr Gly  Val Glu Gln 
    3440                 3445                 3450             


Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu Glu Asp  Glu Thr Ala 
    3455                 3460                 3465             


Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg Leu Cys  Pro Thr Pro 
    3470                 3475                 3480             


Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val Ala Asp  His Gln Gln 
    3485                 3490                 3495             


Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro Gly Ala  Ile Asp Ser 
    3500                 3505                 3510             


Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu Gln Pro  Leu Arg Ala 
    3515                 3520                 3525             


Gly Glu  Val Arg Val Asp Val  Arg Ala Thr Gly Val  Asn Phe Arg 
    3530                 3535                 3540             


Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro Gln Lys  Ala Asp Met 
    3545                 3550                 3555             


Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala Val Gly  Pro Asp Val 
    3560                 3565                 3570             


Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu Gly Leu  Phe Gln Gly 
    3575                 3580                 3585             


Ala Phe  Ala Pro Ile Ala Val  Thr Asp His Arg Leu  Leu Ala Arg 
    3590                 3595                 3600             


Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala Ala Ala  Val Pro Ile 
    3605                 3610                 3615             


Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His Asp Leu  Ala Gly Leu 
    3620                 3625                 3630             


Arg Ala  Gly Gln Ser Val Leu  Ile His Ala Ala Ala  Gly Gly Val 
    3635                 3640                 3645             


Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg Ala Gly  Ala Glu Val 
    3650                 3655                 3660             


Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly Thr Leu  Arg Ala Leu 
    3665                 3670                 3675             


Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser Arg Glu  Thr Gly Phe 
    3680                 3685                 3690             


Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly Arg Gly  Val Asp Val 
    3695                 3700                 3705             


Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu Asp Glu  Ser Ala Asp 
    3710                 3715                 3720             


Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu Met Gly  Lys Thr Asp 
    3725                 3730                 3735             


Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg Tyr Ala  Pro Phe Asp 
    3740                 3745                 3750             


Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly Glu Ile  Leu Arg Glu 
    3755                 3760                 3765             


Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu Asp Arg  Leu Pro Val 
    3770                 3775                 3780             


Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr Gly Lys  Ser Leu Val 
    3785                 3790                 3795             


Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe Arg Pro  Asp Gly Thr 
    3800                 3805                 3810             


Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala 
    3815                 3820                 3825             


Arg His  Leu Val Thr Glu His  Gly Val Arg His Leu  Leu Leu Val 
    3830                 3835                 3840             


Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala 
    3845                 3850                 3855             


Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp 
    3860                 3865                 3870             


Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro 
    3875                 3880                 3885             


Arg Pro  Leu Thr Gly Val Val  His Ala Ala Gly Val  Leu Ala Asp 
    3890                 3895                 3900             


Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu 
    3905                 3910                 3915             


Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala 
    3920                 3925                 3930             


Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser 
    3935                 3940                 3945             


Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu 
    3950                 3955                 3960             


Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro 
    3965                 3970                 3975             


Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile 
    3980                 3985                 3990             


Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly 
    3995                 4000                 4005             


Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser 
    4010                 4015                 4020             


Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala 
    4025                 4030                 4035             


Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn 
    4040                 4045                 4050             


Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro 
    4055                 4060                 4065             


Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val 
    4070                 4075                 4080             


Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln 
    4085                 4090                 4095             


Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu 
    4100                 4105                 4110             


Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val 
    4115                 4120                 4125             


Arg Leu  Pro Ser Thr Leu Val  Phe Asp His Pro Thr  Pro Leu Ala 
    4130                 4135                 4140             


Val Ala  Glu His Leu Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn 
    4145                 4150                 4155             


Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp 
    4160                 4165                 4170             


Leu Arg  Arg Phe Gly Pro Pro  Val Glu His Arg Ala  Arg Leu Val 
    4175                 4180                 4185             


Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu 
    4190                 4195                 4200             


Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val His Ala  Val Gln Tyr 
    4205                 4210                 4215             


Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala 
    4220                 4225                 4230             


Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly 
    4235                 4240                 4245             


Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His Ser Met  Gly Ala Leu 
    4250                 4255                 4260             


Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly 
    4265                 4270                 4275             


Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val 
    4280                 4285                 4290             


His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp 
    4295                 4300                 4305             


Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu 
    4310                 4315                 4320             


Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg 
    4325                 4330                 4335             


Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala 
    4340                 4345                 4350             


Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr 
    4355                 4360                 4365             


Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser Val Ile  Pro Gly Arg 
    4370                 4375                 4380             


Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val 
    4385                 4390                 4395             


Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly 
    4400                 4405                 4410             


Leu Ala  Gly 
    4415     


<210>  43
<211>  3865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOO

<400>  43

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Pro Gly Ile Gly  Ala Leu Val Pro Ala  Pro Val Val 
    2105                 2110                 2115             


Ile Ala  Ala Gly Arg Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met 
    2120                 2125                 2130             


Ala Cys  Arg Leu Pro Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp 
    2135                 2140                 2145             


Glu Leu  Leu Arg Glu Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr 
    2150                 2155                 2160             


Asp Arg  Gly Trp Asp Leu Ala  Arg Leu His His Pro  Asp Pro Asp 
    2165                 2170                 2175             


Asn Pro  Gly Thr Ser Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp 
    2180                 2185                 2190             


Ala Ala  Gly Phe Asp Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu 
    2195                 2200                 2205             


Ala Ala  Ala Met Asp Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser 
    2210                 2215                 2220             


Trp Glu  Leu Val Glu Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg 
    2225                 2230                 2235             


Gly Thr  Ala Thr Gly Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr 
    2240                 2245                 2250             


Gly Glu  Asp Thr Ala Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val 
    2255                 2260                 2265             


Thr Gly  Val Ala Pro Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr 
    2270                 2275                 2280             


Met Gly  Leu Glu Gly Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser 
    2285                 2290                 2295             


Ser Ser  Leu Val Ala Leu His  Leu Ala Val Glu Ser  Leu Arg Lys 
    2300                 2305                 2310             


Gly Glu  Ser Ser Met Ala Val  Val Gly Gly Ala Ala  Val Met Ala 
    2315                 2320                 2325             


Thr Pro  Gly Val Phe Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala 
    2330                 2335                 2340             


Ala Asp  Gly Arg Ser Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe 
    2345                 2350                 2355             


Gly Phe  Ser Glu Gly Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser 
    2360                 2365                 2370             


Glu Ala  Arg Arg Asn Gly His  Glu Val Leu Ala Val  Val Arg Gly 
    2375                 2380                 2385             


Ser Ala  Leu Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro 
    2390                 2395                 2400             


Ser Gly  Pro Ala Gln Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser 
    2405                 2410                 2415             


Cys Gly  Leu Glu Pro Gly Asp  Val Asp Ala Val Glu  Ala His Gly 
    2420                 2425                 2430             


Thr Gly  Thr Ala Leu Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu 
    2435                 2440                 2445             


Asp Thr  Tyr Gly Arg Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu 
    2450                 2455                 2460             


Gly Ser  Val Lys Ser Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly 
    2465                 2470                 2475             


Val Thr  Gly Leu Leu Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu 
    2480                 2485                 2490             


Leu Pro  Ala Thr Leu His Val  Glu Glu Pro Thr Pro  His Val Asp 
    2495                 2500                 2505             


Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp 
    2510                 2515                 2520             


Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly 
    2525                 2530                 2535             


Ile Ser  Gly Thr Asn Ala His  Val Ile Val Glu Glu  Ala Pro Gln 
    2540                 2545                 2550             


Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser 
    2555                 2560                 2565             


Thr Leu  Val Val Ala Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr 
    2570                 2575                 2580             


Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val 
    2585                 2590                 2595             


Ala Leu  Ala Asp Val Ala His  Thr Leu Asn His His  Arg Ser Arg 
    2600                 2605                 2610             


Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala 
    2615                 2620                 2625             


Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly 
    2630                 2635                 2640             


Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe 
    2645                 2650                 2655             


Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu 
    2660                 2665                 2670             


Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg Ile His  Gln Gln Val 
    2675                 2680                 2685             


Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly 
    2690                 2695                 2700             


Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly 
    2705                 2710                 2715             


Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp Ala Val  Val Gly His 
    2720                 2725                 2730             


Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser 
    2735                 2740                 2745             


Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met 
    2750                 2755                 2760             


Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala Ala Val  Pro Val Ser 
    2765                 2770                 2775             


Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala 
    2780                 2785                 2790             


Ala Val  Asn Gly Pro Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala 
    2795                 2800                 2805             


Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu 
    2810                 2815                 2820             


Pro Thr  Ser His Ala Phe His  Ser Ala Arg Met Glu  Pro Met Leu 
    2825                 2830                 2835             


Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro 
    2840                 2845                 2850             


Gln Val  Ala Met Ala Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr 
    2855                 2860                 2865             


Trp Val  Arg Gln Val Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val 
    2870                 2875                 2880             


Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg 
    2885                 2890                 2895             


Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala Met Leu  His Gly Asp 
    2900                 2905                 2910             


His Glu  Ala Gln Ala Ala Asp  His Arg Gln Ile Thr  Glu Ala Val 
    2915                 2920                 2925             


Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro Asp Phe  Ala Ala Leu 
    2930                 2935                 2940             


Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu Pro Thr  Tyr Pro Phe 
    2945                 2950                 2955             


Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala Arg Glu  Arg Pro Glu 
    2960                 2965                 2970             


Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr Glu Ala  Val Arg Leu 
    2975                 2980                 2985             


Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala Ala Leu  Leu Gly Gly 
    2990                 2995                 3000             


Ala Ser  Asp Asp Gln His Thr  Leu Gln Val Leu Thr  Lys Leu Ala 
    3005                 3010                 3015             


Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg Ser Ile  Ala Asp Asp 
    3020                 3025                 3030             


Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr Ser Pro  Leu Ser Gly 
    3035                 3040                 3045             


Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile Val Val  Ser Asp Asp 
    3050                 3055                 3060             


Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu Leu Ala  Ala Arg Asn 
    3065                 3070                 3075             


Glu Pro  His Gln Val Val Gly  Leu Pro Ala Ser Asp  Ala Asp Glu 
    3080                 3085                 3090             


Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala Ala Thr  Glu Asp Ala 
    3095                 3100                 3105             


Thr Leu  Arg Ile Val His Val  Ala Ala Leu Glu Ala  Gly Ala Thr 
    3110                 3115                 3120             


Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln His Arg  Ile Leu Gly 
    3125                 3130                 3135             


Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val Ala Ala  Glu Leu Arg 
    3140                 3145                 3150             


Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala Gln Arg  Val Ala Asp 
    3155                 3160                 3165             


Thr Asp  Thr Val Ala Pro His  Gln Ser Cys Leu Trp  Gly Phe Gly 
    3170                 3175                 3180             


Arg Ala  Ala Ser Leu Glu Leu  Pro His Val Trp Gly  Gly Leu Ala 
    3185                 3190                 3195             


Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala Asp Glu  Trp Ser Ala 
    3200                 3205                 3210             


Leu Val  Asp Arg Ile Ala Ala  Pro His Gly Ser Ala  Val Arg Glu 
    3215                 3220                 3225             


Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val Tyr Thr  Pro Arg Leu 
    3230                 3235                 3240             


Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr Pro Leu  His Leu Arg 
    3245                 3250                 3255             


Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly Thr Gly  Thr Leu Gly 
    3260                 3265                 3270             


Arg Leu  Leu Ala Arg His Leu  Val Thr Glu His Gly  Val Arg His 
    3275                 3280                 3285             


Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp Ala Pro  Gly Ser Asp 
    3290                 3295                 3300             


Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly Ala Ser  Ala Glu Ile 
    3305                 3310                 3315             


Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala Leu Ser  Ala Leu Leu 
    3320                 3325                 3330             


Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val Val His  Ala Ala Gly 
    3335                 3340                 3345             


Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile Asp Glu  Pro Ala Val 
    3350                 3355                 3360             


Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala Ala Trp  Asn Leu His 
    3365                 3370                 3375             


Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe Phe Val  Leu Phe Ser 
    3380                 3385                 3390             


Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly Gln Gly  Val Tyr Ala 
    3395                 3400                 3405             


Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala Ala Leu  Arg Arg Thr 
    3410                 3415                 3420             


Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp Gly Leu  Trp Ala Ile 
    3425                 3430                 3435             


Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr Gly Asp  Ala Ile Ala 
    3440                 3445                 3450             


Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr Leu Leu  Arg His Asn 
    3455                 3460                 3465             


Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile Gly Ser  Pro Trp Leu 
    3470                 3475                 3480             


Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala Glu Lys  Phe Gln Ser 
    3485                 3490                 3495             


Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys Phe Leu  Ala Glu Leu 
    3500                 3505                 3510             


Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp Arg Leu  Arg Arg Leu 
    3515                 3520                 3525             


Leu Glu  Leu Val Arg Ser His  Ala Ala Ala Val Ser  Gly Tyr Gly 
    3530                 3535                 3540             


Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala Phe Lys  Asp Leu Gly 
    3545                 3550                 3555             


Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg Asn Arg  Leu Gly Thr 
    3560                 3565                 3570             


Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu Val Phe  Asp His Pro 
    3575                 3580                 3585             


Thr Pro  Leu Ala Val Ala Glu  His Leu Arg Asp Arg  Leu Thr Ser 
    3590                 3595                 3600             


Gly Glu  Asp Asn Pro Ile Pro  Leu Cys Gln Gly Asp  Gly Glu Glu 
    3605                 3610                 3615             


Met Ser  Thr Trp Leu Arg Arg  Phe Gly Pro Pro Val  Glu His Arg 
    3620                 3625                 3630             


Ala Arg  Leu Val Cys Phe Pro  His Ala Gly Ala Ala  Ala Asp Ser 
    3635                 3640                 3645             


Tyr Leu  Asp Leu Ala Arg Ala  Leu Ala Pro Glu Ile  Asp Val His 
    3650                 3655                 3660             


Ala Val  Gln Tyr Pro Gly Arg  Gln Asp Arg Arg Asp  Glu Glu Pro 
    3665                 3670                 3675             


Leu Gly  Thr Ala Gly Glu Ile  Ala Asp Glu Val Ala  Ala Val Leu 
    3680                 3685                 3690             


Arg Ala  Ser Gly Gly Asp Gly  Pro Phe Ala Leu Phe  Gly His Ser 
    3695                 3700                 3705             


Met Gly  Ala Leu Ile Ala Tyr  Glu Thr Ala Arg Arg  Leu Glu Arg 
    3710                 3715                 3720             


Glu Pro  Gly Gly Gly Pro Leu  Arg Leu Phe Val Ser  Gly Gln Thr 
    3725                 3730                 3735             


Ala Pro  Arg Val His Glu Arg  Arg Thr Asp Leu Pro  Gly Asp Asp 
    3740                 3745                 3750             


Gly Leu  Val Asp Glu Leu Arg  Arg Leu Gly Thr Ser  Glu Ala Ala 
    3755                 3760                 3765             


Leu Ala  Asp Glu Ala Leu Leu  Ala Met Ser Leu Pro  Val Leu Arg 
    3770                 3775                 3780             


Ala Asp  Tyr Arg Val Leu Arg  Ser Tyr Ala Trp Ala  Asp Gly Pro 
    3785                 3790                 3795             


Pro Leu  Arg Ala Gly Ile Thr  Ala Leu Cys Gly Asp  Ala Asp Pro 
    3800                 3805                 3810             


Leu Thr  Ala Thr Gly Asp Ala  Glu Arg Trp Leu Gln  His Ser Val 
    3815                 3820                 3825             


Ile Pro  Gly Arg Thr Arg Thr  Phe Pro Gly Gly His  Phe Tyr Leu 
    3830                 3835                 3840             


Gly Glu  Gln Val Thr Glu Val  Ala Gly Ala Val Arg  Arg Asp Leu 
    3845                 3850                 3855             


Leu Arg  Ala Gly Leu Ala Gly  
    3860                 3865 


<210>  44
<211>  3978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IOS

<400>  44

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Leu Pro Val Glu  Gln Pro Phe Val His  Ser Pro Glu 
    2105                 2110                 2115             


Glu Arg  Tyr Arg Pro Phe Ala  Leu Thr Asp Val Gln  Gln Ala Tyr 
    2120                 2125                 2130             


Leu Val  Gly Arg Gln Pro Gly  Phe Ala Leu Gly Gly  Val Gly Ser 
    2135                 2140                 2145             


His Phe  Phe Val Glu Phe Glu  Ile Ala Asp Leu Asp  Ile His Arg 
    2150                 2155                 2160             


Leu Glu  Lys Val Trp Asn Arg  Leu Ile Ala Arg His  Asp Met Leu 
    2165                 2170                 2175             


Arg Ala  Val Val Arg Asp Gly  Gln Gln Arg Val Leu  Glu Gln Thr 
    2180                 2185                 2190             


Pro Pro  Trp Val Ile Pro Ala  His Ile Leu His Ser  Pro Glu Glu 
    2195                 2200                 2205             


Ala Leu  Gln Val Arg Asp Arg  Leu Ala His Gln Val  Leu Asn Pro 
    2210                 2215                 2220             


Glu Val  Trp Pro Val Phe Asp  Leu Gln Val Gly Phe  Val Asp Gly 
    2225                 2230                 2235             


Met Pro  Ala Arg Leu Trp Leu  Cys Leu Asp Asn Leu  Leu Leu Asp 
    2240                 2245                 2250             


Gly Leu  Ser Met Gln Ile Leu  Leu Ser Glu Leu Glu  His Gly Tyr 
    2255                 2260                 2265             


Arg Tyr  Pro Gln Gln Leu Pro  Pro Pro Leu Pro Ile  Thr Phe Arg 
    2270                 2275                 2280             


Asp Tyr  Leu Gln Gln Pro Ala  Leu Arg Thr Pro Asn  Pro Asp Ser 
    2285                 2290                 2295             


Leu Ala  Trp Trp Gln Thr Gln  Leu Asp Asp Ile Pro  Pro Ala Pro 
    2300                 2305                 2310             


Ala Leu  Pro Leu Arg Cys Leu  Pro Gln Asp Val Glu  Thr Pro Arg 
    2315                 2320                 2325             


Phe Ala  Arg Leu Tyr Gly Ala  Met Asp Ser Ala Arg  Trp Arg Arg 
    2330                 2335                 2340             


Leu Lys  Gln Arg Ala Ala Asp  Ala His Leu Thr Pro  Ser Ala Val 
    2345                 2350                 2355             


Leu Leu  Ser Val Trp Ser Thr  Val Leu Ala Ala Trp  Ser Ala Gln 
    2360                 2365                 2370             


Pro Asp  Phe Thr Leu Asn Leu  Thr Leu Phe Asp Arg  Arg Pro Leu 
    2375                 2380                 2385             


His Pro  Gln Ile Asn Gln Ile  Leu Gly Asp Phe Thr  Ser Leu Met 
    2390                 2395                 2400             


Leu Leu  Ser Trp His Pro Gly  Glu Ser Trp Leu Gln  Ser Ala Arg 
    2405                 2410                 2415             


Leu Leu  Gln Gln Arg Leu Ser  Glu Ser Leu Asn His  Arg Asp Val 
    2420                 2425                 2430             


Ser Ala  Ile Arg Val Met Arg  Gln Leu Ala Arg Arg  Gln Asn Val 
    2435                 2440                 2445             


Pro Ala  Val Pro Met Pro Val  Val Phe Thr Ser Ala  Leu Gly Phe 
    2450                 2455                 2460             


Glu Gln  Asp Asn Phe Leu Ala  Arg Arg Asn Leu Leu  Lys Pro Val 
    2465                 2470                 2475             


Trp Gly  Ile Ser Gln Thr Pro  Gln Val Trp Leu Asp  His Gln Val 
    2480                 2485                 2490             


Tyr Glu  Ser Glu Gly Glu Leu  Arg Phe Asn Trp Asp  Phe Val Ala 
    2495                 2500                 2505             


Ala Leu  Phe Pro Asp Gly Gln  Val Glu Arg Gln Phe  Ala Gln Tyr 
    2510                 2515                 2520             


Cys Ala  Leu Leu Asn Arg Met  Ala Glu Asp Asp Ser  Ser Trp Gln 
    2525                 2530                 2535             


Leu Pro  Leu Ala Asp Leu Val  Pro Pro Leu Lys Val  Thr Glu Arg 
    2540                 2545                 2550             


Arg Ala  Arg Arg Leu Arg Pro  Glu Arg Ala Gln Pro  Arg Ile Ala 
    2555                 2560                 2565             


Ala Asp  Lys Ser Ser Val Ser  Leu Ile Cys Asp Thr  Phe Arg Glu 
    2570                 2575                 2580             


Val Val  Gly Glu Pro Val Ala  Pro Ala Glu Asn Phe  Phe Glu Ala 
    2585                 2590                 2595             


Gly Ala  Thr Ser Leu Asn Leu  Val Gln Leu His Val  Leu Leu Gln 
    2600                 2605                 2610             


Arg His  Glu Phe Ala Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His 
    2615                 2620                 2625             


Pro Ser  Pro Val Ala Leu Ala  Asn Tyr Leu Ala Gly  Val Ala Leu 
    2630                 2635                 2640             


Glu Glu  Lys Thr Lys Arg Val  Arg Pro Val Arg Arg  Arg Gln Arg 
    2645                 2650                 2655             


Arg Ile  Gln His Leu Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp 
    2660                 2665                 2670             


Met Ala  Glu Lys Leu Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala 
    2675                 2680                 2685             


His Tyr  Val Glu Leu Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala 
    2690                 2695                 2700             


Arg Ala  Val Val Ala Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met 
    2705                 2710                 2715             


Arg Phe  Thr Glu Asp Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp 
    2720                 2725                 2730             


Ala Leu  Thr Phe Glu Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn 
    2735                 2740                 2745             


Ile Asp  Pro His Gly Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu 
    2750                 2755                 2760             


Gln Gln  Asp Leu Arg Val Asp  Ser Gly Lys Pro Leu  Val Phe His 
    2765                 2770                 2775             


Gln Leu  Ile Gln Val Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg 
    2780                 2785                 2790             


Tyr His  His Leu Leu Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr 
    2795                 2800                 2805             


Arg Gln  Ile Ala Asn Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro 
    2810                 2815                 2820             


Thr Pro  Ala Ser Pro Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu 
    2825                 2830                 2835             


Tyr Gln  Gln Tyr Arg Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala 
    2840                 2845                 2850             


Phe Trp  Ala Glu Gln Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu 
    2855                 2860                 2865             


Ser Pro  Ala Pro Leu Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu 
    2870                 2875                 2880             


Arg Leu  Lys Leu Glu Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala 
    2885                 2890                 2895             


Thr Gln  Leu Ser Gly Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu 
    2900                 2905                 2910             


Ala Ala  Leu Trp Leu Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala 
    2915                 2920                 2925             


Ala Gly  Phe Ile Phe Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr 
    2930                 2935                 2940             


Ala Thr  Gly Pro Val Leu Asn  Val Leu Pro Leu Gly  Ile His Ile 
    2945                 2950                 2955             


Gly Asn  Pro Ser Phe Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val 
    2960                 2965                 2970             


Ala Leu  Gly Ala Tyr Ala His  Gln His Ile Pro Phe  Glu Met Leu 
    2975                 2980                 2985             


Val Glu  Ala Leu Gln Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu 
    2990                 2995                 3000             


Phe Gln  Val Met Phe Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu 
    3005                 3010                 3015             


Glu Leu  Thr Gly Ile Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr 
    3020                 3025                 3030             


Thr Thr  Lys Phe Asp Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser 
    3035                 3040                 3045             


Gly Leu  Val Gly Val Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala 
    3050                 3055                 3060             


Ser Thr  Ile Glu Arg Met Thr  Gly His Phe Val Thr  Leu Leu Glu 
    3065                 3070                 3075             


Gly Val  Ile Ala Asn Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile 
    3080                 3085                 3090             


Leu Thr  Thr Val Glu Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn 
    3095                 3100                 3105             


Thr Gln  Thr Asp Tyr Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe 
    3110                 3115                 3120             


Glu Glu  Gln Val Glu Arg Thr  Pro Asp Ala Val Ala  Val Val Phe 
    3125                 3130                 3135             


Gly Asn  Gln Gln Leu Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val 
    3140                 3145                 3150             


Ala Leu  Ala Asn Leu Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp 
    3155                 3160                 3165             


Ser Val  Ala Val Ala Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala 
    3170                 3175                 3180             


Leu His  Ala Ile Val Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp 
    3185                 3190                 3195             


Thr Gly  Tyr Pro Asp Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala 
    3200                 3205                 3210             


Arg Pro  Ser Leu Leu Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe 
    3215                 3220                 3225             


Ser Asp  Val Pro Asn Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu 
    3230                 3235                 3240             


Thr Pro  Gln Gly Ser Ala Pro  Leu Gln Leu Ser Gln  Pro His His 
    3245                 3250                 3255             


Thr Ala  Tyr Ile Ile Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys 
    3260                 3265                 3270             


Gly Val  Met Val Gly Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp 
    3275                 3280                 3285             


Met Gln  Asn His Tyr Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln 
    3290                 3295                 3300             


Lys Thr  Pro Cys Ser Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp 
    3305                 3310                 3315             


Pro Phe  Ile Ala Gly Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala 
    3320                 3325                 3330             


His Arg  Asp Pro Leu Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly 
    3335                 3340                 3345             


Val Thr  Thr Thr His Phe Val  Pro Ser Met Leu Ala  Ala Phe Val 
    3350                 3355                 3360             


Ala Ser  Leu Thr Pro Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu 
    3365                 3370                 3375             


Lys Gln  Val Phe Cys Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys 
    3380                 3385                 3390             


Arg Glu  Trp Gln Gln Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr 
    3395                 3400                 3405             


Gly Pro  Thr Glu Ala Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe 
    3410                 3415                 3420             


Gly Glu  Glu Leu Ala Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly 
    3425                 3430                 3435             


Tyr Pro  Val Trp Asn Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met 
    3440                 3445                 3450             


His Pro  Val Pro Pro Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly 
    3455                 3460                 3465             


Ile Gln  Leu Ala Gln Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala 
    3470                 3475                 3480             


Ser Arg  Phe Ile Ala Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr 
    3485                 3490                 3495             


Arg Thr  Gly Asp Val Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu 
    3500                 3505                 3510             


Tyr Leu  Gly Arg Ser Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg 
    3515                 3520                 3525             


Ile Glu  Leu Gly Glu Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp 
    3530                 3535                 3540             


Val Glu  Gln Ala Val Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile 
    3545                 3550                 3555             


Pro Gly  Asn Lys His Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu 
    3560                 3565                 3570             


Gln Thr  Cys Thr Glu Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe 
    3575                 3580                 3585             


Val Arg  Ser Phe Leu Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro 
    3590                 3595                 3600             


Ser Ala  Ile Val Ile Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly 
    3605                 3610                 3615             


Lys Leu  Asp Arg Arg Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln 
    3620                 3625                 3630             


Leu Glu  Thr Ile Ile Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys 
    3635                 3640                 3645             


Asp Val  Gln Asp Ala Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His 
    3650                 3655                 3660             


Ser Leu  Leu Ala Met Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val 
    3665                 3670                 3675             


Ala Arg  Gln Val Thr Pro Gly  Gln Val Met Val Ala  Ser Thr Val 
    3680                 3685                 3690             


Ala Lys  Leu Ala Thr Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val 
    3695                 3700                 3705             


Ala Pro  Arg Asn Pro Ile Thr  Ser Gly Glu Asp Asn  Pro Ile Pro 
    3710                 3715                 3720             


Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg 
    3725                 3730                 3735             


Phe Gly  Pro Pro Val Glu His  Arg Ala Arg Leu Val  Cys Phe Pro 
    3740                 3745                 3750             


His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala 
    3755                 3760                 3765             


Leu Ala  Pro Glu Ile Asp Val  His Ala Val Gln Tyr  Pro Gly Arg 
    3770                 3775                 3780             


Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile 
    3785                 3790                 3795             


Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly 
    3800                 3805                 3810             


Pro Phe  Ala Leu Phe Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr 
    3815                 3820                 3825             


Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu 
    3830                 3835                 3840             


Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro Arg Val  His Glu Arg 
    3845                 3850                 3855             


Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg 
    3860                 3865                 3870             


Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu 
    3875                 3880                 3885             


Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg 
    3890                 3895                 3900             


Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr 
    3905                 3910                 3915             


Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala 
    3920                 3925                 3930             


Glu Arg  Trp Leu Gln His Ser  Val Ile Pro Gly Arg  Thr Arg Thr 
    3935                 3940                 3945             


Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val 
    3950                 3955                 3960             


Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    3965                 3970                 3975             


<210>  45
<211>  4093
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISC

<400>  45

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gln His Leu 
    1160                 1165                 1170             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    1175                 1180                 1185             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    1190                 1195                 1200             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    1205                 1210                 1215             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    1220                 1225                 1230             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    1235                 1240                 1245             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    1250                 1255                 1260             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    1265                 1270                 1275             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    1280                 1285                 1290             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    1295                 1300                 1305             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    1310                 1315                 1320             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    1325                 1330                 1335             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    1340                 1345                 1350             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    1355                 1360                 1365             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    1370                 1375                 1380             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    1385                 1390                 1395             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    1400                 1405                 1410             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    1415                 1420                 1425             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    1430                 1435                 1440             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    1445                 1450                 1455             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    1460                 1465                 1470             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    1475                 1480                 1485             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    1490                 1495                 1500             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    1505                 1510                 1515             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    1520                 1525                 1530             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    1535                 1540                 1545             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    1550                 1555                 1560             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    1565                 1570                 1575             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    1580                 1585                 1590             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    1595                 1600                 1605             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    1610                 1615                 1620             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    1625                 1630                 1635             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    1640                 1645                 1650             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    1655                 1660                 1665             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    1670                 1675                 1680             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    1685                 1690                 1695             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    1700                 1705                 1710             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    1715                 1720                 1725             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    1730                 1735                 1740             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    1745                 1750                 1755             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    1760                 1765                 1770             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    1775                 1780                 1785             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    1790                 1795                 1800             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    1805                 1810                 1815             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    1820                 1825                 1830             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    1835                 1840                 1845             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    1850                 1855                 1860             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    1865                 1870                 1875             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    1880                 1885                 1890             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    1895                 1900                 1905             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    1910                 1915                 1920             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    1925                 1930                 1935             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    1940                 1945                 1950             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    1955                 1960                 1965             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    1970                 1975                 1980             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    1985                 1990                 1995             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    2000                 2005                 2010             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    2015                 2020                 2025             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    2030                 2035                 2040             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    2045                 2050                 2055             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    2060                 2065                 2070             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    2075                 2080                 2085             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    2090                 2095                 2100             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    2105                 2110                 2115             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    2120                 2125                 2130             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    2135                 2140                 2145             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    2150                 2155                 2160             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    2165                 2170                 2175             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    2180                 2185                 2190             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    2195                 2200                 2205             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    2210                 2215                 2220             


Ile Leu  Pro Val Glu Gln Pro  Phe Val His Ser Pro  Glu Glu Arg 
    2225                 2230                 2235             


Tyr Arg  Pro Phe Ala Leu Thr  Asp Val Gln Gln Ala  Tyr Leu Val 
    2240                 2245                 2250             


Gly Arg  Gln Pro Gly Phe Ala  Leu Gly Gly Val Gly  Ser His Phe 
    2255                 2260                 2265             


Phe Val  Glu Phe Glu Ile Ala  Asp Leu Asp Ile His  Arg Leu Glu 
    2270                 2275                 2280             


Lys Val  Trp Asn Arg Leu Ile  Ala Arg His Asp Met  Leu Arg Ala 
    2285                 2290                 2295             


Val Val  Arg Asp Gly Gln Gln  Arg Val Leu Glu Gln  Thr Pro Pro 
    2300                 2305                 2310             


Trp Val  Ile Pro Ala His Ile  Leu His Ser Pro Glu  Glu Ala Leu 
    2315                 2320                 2325             


Gln Val  Arg Asp Arg Leu Ala  His Gln Val Leu Asn  Pro Glu Val 
    2330                 2335                 2340             


Trp Pro  Val Phe Asp Leu Gln  Val Gly Phe Val Asp  Gly Met Pro 
    2345                 2350                 2355             


Ala Arg  Leu Trp Leu Cys Leu  Asp Asn Leu Leu Leu  Asp Gly Leu 
    2360                 2365                 2370             


Ser Met  Gln Ile Leu Leu Ser  Glu Leu Glu His Gly  Tyr Arg Tyr 
    2375                 2380                 2385             


Pro Gln  Gln Leu Pro Pro Pro  Leu Pro Ile Thr Phe  Arg Asp Tyr 
    2390                 2395                 2400             


Leu Gln  Gln Pro Ala Leu Arg  Thr Pro Asn Pro Asp  Ser Leu Ala 
    2405                 2410                 2415             


Trp Trp  Gln Thr Gln Leu Asp  Asp Ile Pro Pro Ala  Pro Ala Leu 
    2420                 2425                 2430             


Pro Leu  Arg Cys Leu Pro Gln  Asp Val Glu Thr Pro  Arg Phe Ala 
    2435                 2440                 2445             


Arg Leu  Tyr Gly Ala Met Asp  Ser Ala Arg Trp Arg  Arg Leu Lys 
    2450                 2455                 2460             


Gln Arg  Ala Ala Asp Ala His  Leu Thr Pro Ser Ala  Val Leu Leu 
    2465                 2470                 2475             


Ser Val  Trp Ser Thr Val Leu  Ala Ala Trp Ser Ala  Gln Pro Asp 
    2480                 2485                 2490             


Phe Thr  Leu Asn Leu Thr Leu  Phe Asp Arg Arg Pro  Leu His Pro 
    2495                 2500                 2505             


Gln Ile  Asn Gln Ile Leu Gly  Asp Phe Thr Ser Leu  Met Leu Leu 
    2510                 2515                 2520             


Ser Trp  His Pro Gly Glu Ser  Trp Leu Gln Ser Ala  Arg Leu Leu 
    2525                 2530                 2535             


Gln Gln  Arg Leu Ser Glu Ser  Leu Asn His Arg Asp  Val Ser Ala 
    2540                 2545                 2550             


Ile Arg  Val Met Arg Gln Leu  Ala Arg Arg Gln Asn  Val Pro Ala 
    2555                 2560                 2565             


Val Pro  Met Pro Val Val Phe  Thr Ser Ala Leu Gly  Phe Glu Gln 
    2570                 2575                 2580             


Asp Asn  Phe Leu Ala Arg Arg  Asn Leu Leu Lys Pro  Val Trp Gly 
    2585                 2590                 2595             


Ile Ser  Gln Thr Pro Gln Val  Trp Leu Asp His Gln  Val Tyr Glu 
    2600                 2605                 2610             


Ser Glu  Gly Glu Leu Arg Phe  Asn Trp Asp Phe Val  Ala Ala Leu 
    2615                 2620                 2625             


Phe Pro  Asp Gly Gln Val Glu  Arg Gln Phe Ala Gln  Tyr Cys Ala 
    2630                 2635                 2640             


Leu Leu  Asn Arg Met Ala Glu  Asp Asp Ser Ser Trp  Gln Leu Pro 
    2645                 2650                 2655             


Leu Ala  Asp Leu Val Pro Pro  Leu Lys Val Thr Glu  Arg Arg Ala 
    2660                 2665                 2670             


Arg Arg  Leu Arg Pro Glu Arg  Ala Gln Pro Arg Ile  Ala Ala Asp 
    2675                 2680                 2685             


Lys Ser  Ser Val Ser Leu Ile  Cys Asp Thr Phe Arg  Glu Val Val 
    2690                 2695                 2700             


Gly Glu  Pro Val Ala Pro Ala  Glu Asn Phe Phe Glu  Ala Gly Ala 
    2705                 2710                 2715             


Thr Ser  Leu Asn Leu Val Gln  Leu His Val Leu Leu  Gln Arg His 
    2720                 2725                 2730             


Glu Phe  Ala Thr Leu Thr Leu  Leu Asp Leu Phe Thr  His Pro Ser 
    2735                 2740                 2745             


Pro Val  Ala Leu Ala Asn Tyr  Leu Ala Gly Val Ala  Leu Glu Glu 
    2750                 2755                 2760             


Lys Thr  Lys Arg Val Arg Pro  Val Arg Arg Arg Gln  Arg Arg Ile 
    2765                 2770                 2775             


Gly Glu  Pro Phe Pro Leu Ala  Pro Met Gln His Ala  Met Trp Val 
    2780                 2785                 2790             


Gly Arg  His Asp His Gln Gln  Leu Gly Gly Val Ala  Gly His Leu 
    2795                 2800                 2805             


Tyr Val  Glu Phe Asp Gly Ala  Arg Val Asp Pro Asp  Arg Leu Arg 
    2810                 2815                 2820             


Ala Ala  Ala Thr Arg Leu Ala  Leu Arg His Pro Met  Leu Arg Val 
    2825                 2830                 2835             


Gln Phe  Leu Pro Asp Gly Thr  Gln Arg Ile Pro Pro  Ala Ala Gly 
    2840                 2845                 2850             


Ser Arg  Asp Phe Pro Ile Ser  Val Ala Asp Leu Arg  His Val Ala 
    2855                 2860                 2865             


Pro Asp  Val Val Asp Gln Arg  Leu Ala Gly Ile Arg  Asp Ala Lys 
    2870                 2875                 2880             


Ser His  Gln Gln Leu Asp Gly  Ala Val Phe Glu Leu  Ala Leu Thr 
    2885                 2890                 2895             


Leu Leu  Pro Gly Glu Arg Thr  Arg Leu His Val Asp  Leu Asp Met 
    2900                 2905                 2910             


Gln Ala  Ala Asp Ala Met Ser  Tyr Arg Ile Leu Leu  Ala Asp Leu 
    2915                 2920                 2925             


Ala Ala  Leu Tyr Asp Gly Arg  Glu Pro Pro Ala Leu  Gly Tyr Thr 
    2930                 2935                 2940             


Tyr Arg  Glu Tyr Arg Gln Ala  Ile Glu Ala Glu Glu  Thr Leu Pro 
    2945                 2950                 2955             


Gln Pro  Val Arg Asp Ala Asp  Arg Asp Trp Trp Ala  Gln Arg Ile 
    2960                 2965                 2970             


Pro Gln  Leu Pro Asp Pro Pro  Ala Leu Pro Thr Arg  Ala Gly Gly 
    2975                 2980                 2985             


Glu Arg  Asp Arg Arg Arg Ser  Thr Arg Arg Trp His  Trp Leu Asp 
    2990                 2995                 3000             


Pro Gln  Thr Arg Asp Ala Leu  Phe Ala Arg Ala Arg  Ala Arg Gly 
    3005                 3010                 3015             


Ile Thr  Pro Ala Met Thr Leu  Ala Ala Ala Phe Ala  Asn Val Leu 
    3020                 3025                 3030             


Ala Arg  Trp Ser Ala Ser Ser  Arg Phe Leu Leu Asn  Leu Pro Leu 
    3035                 3040                 3045             


Phe Ser  Arg Gln Ala Leu His  Pro Asp Val Asp Leu  Leu Val Gly 
    3050                 3055                 3060             


Asp Phe  Thr Ser Ser Leu Leu  Leu Asp Val Asp Leu  Gly Asp Thr 
    3065                 3070                 3075             


Val Ser  Asn Leu Ala Arg Lys  Asn Gln Leu Thr Phe  Thr Glu Asp 
    3080                 3085                 3090             


Trp Glu  His Arg His Trp Ser  Gly Val Glu Leu Leu  Arg Glu Leu 
    3095                 3100                 3105             


Lys Arg  Gln Gln Arg Tyr Pro  His Gly Ala Pro Val  Val Phe Thr 
    3110                 3115                 3120             


Ser Asn  Leu Gly Arg Ser Leu  Tyr Ser Ser Arg Ala  Glu Ser Pro 
    3125                 3130                 3135             


Leu Gly  Glu Pro Glu Trp Gly  Ile Ser Gln Thr Pro  Gln Val Trp 
    3140                 3145                 3150             


Ile Asp  His Leu Ala Phe Glu  His His Gly Glu Val  Trp Leu Gln 
    3155                 3160                 3165             


Trp Asp  Ser Asn Asp Ala Leu  Phe Pro Pro Ala Leu  Val Glu Thr 
    3170                 3175                 3180             


Leu Phe  Asp Ala Tyr Cys Gln  Leu Ile Asn Gln Leu  Cys Asp Asp 
    3185                 3190                 3195             


Glu Ser  Ala Trp Gln Lys Pro  Phe Ala Asp Met Met  Pro Ala Ser 
    3200                 3205                 3210             


Gln Arg  Ala Ile Arg Glu Arg  Val Asn Ala Thr Gly  Ala Pro Ile 
    3215                 3220                 3225             


Pro Glu  Gly Leu Leu His Glu  Gly Ile Phe Arg Ile  Ala Leu Gln 
    3230                 3235                 3240             


Gln Pro  Gln Ala Leu Ala Val  Thr Asp Met Arg Tyr  Gln Trp Asn 
    3245                 3250                 3255             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    3260                 3265                 3270             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    3275                 3280                 3285             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    3290                 3295                 3300             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    3305                 3310                 3315             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    3320                 3325                 3330             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    3335                 3340                 3345             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    3350                 3355                 3360             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    3365                 3370                 3375             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    3380                 3385                 3390             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    3395                 3400                 3405             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    3410                 3415                 3420             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    3425                 3430                 3435             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    3440                 3445                 3450             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    3455                 3460                 3465             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    3470                 3475                 3480             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    3485                 3490                 3495             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    3500                 3505                 3510             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    3515                 3520                 3525             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    3530                 3535                 3540             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    3545                 3550                 3555             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    3560                 3565                 3570             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    3575                 3580                 3585             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    3590                 3595                 3600             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    3605                 3610                 3615             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    3620                 3625                 3630             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    3635                 3640                 3645             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    3650                 3655                 3660             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    3665                 3670                 3675             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    3680                 3685                 3690             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    3695                 3700                 3705             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    3710                 3715                 3720             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    3725                 3730                 3735             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Leu  Asp Lys Tyr 
    3740                 3745                 3750             


Val Ala  Pro Arg Asn Pro Ile  Glu Thr Ile Ile Ala  Ala Ala Phe 
    3755                 3760                 3765             


Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp Ala Asp  Ala Asp Phe 
    3770                 3775                 3780             


Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala Met Lys  Leu Ala Ala 
    3785                 3790                 3795             


Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val Thr Pro  Gly Gln Val 
    3800                 3805                 3810             


Met Val  Ala Ser Thr Val Ala  Lys Leu Ala Thr Ile  Ile Asp Ala 
    3815                 3820                 3825             


Glu Thr  Ser Gly Glu Asp Asn  Pro Ile Pro Leu Cys  Gln Gly Asp 
    3830                 3835                 3840             


Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg Phe Gly  Pro Pro Val 
    3845                 3850                 3855             


Glu His  Arg Ala Arg Leu Val  Cys Phe Pro His Ala  Gly Ala Ala 
    3860                 3865                 3870             


Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala Leu Ala  Pro Glu Ile 
    3875                 3880                 3885             


Asp Val  His Ala Val Gln Tyr  Pro Gly Arg Gln Asp  Arg Arg Asp 
    3890                 3895                 3900             


Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile Ala Asp  Glu Val Ala 
    3905                 3910                 3915             


Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly Pro Phe  Ala Leu Phe 
    3920                 3925                 3930             


Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr Glu Thr  Ala Arg Arg 
    3935                 3940                 3945             


Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu Arg Leu  Phe Val Ser 
    3950                 3955                 3960             


Gly Gln  Thr Ala Pro Arg Val  His Glu Arg Arg Thr  Asp Leu Pro 
    3965                 3970                 3975             


Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg Arg Leu  Gly Thr Ser 
    3980                 3985                 3990             


Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu Ala Met  Ser Leu Pro 
    3995                 4000                 4005             


Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg Ser Tyr  Ala Trp Ala 
    4010                 4015                 4020             


Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr Ala Leu  Cys Gly Asp 
    4025                 4030                 4035             


Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala Glu Arg  Trp Leu Gln 
    4040                 4045                 4050             


His Ser  Val Ile Pro Gly Arg  Thr Arg Thr Phe Pro  Gly Gly His 
    4055                 4060                 4065             


Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val Ala Gly  Ala Val Arg 
    4070                 4075                 4080             


Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    4085                 4090             


<210>  46
<211>  4534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISH

<400>  46

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gln His Leu 
    1160                 1165                 1170             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    1175                 1180                 1185             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    1190                 1195                 1200             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    1205                 1210                 1215             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    1220                 1225                 1230             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    1235                 1240                 1245             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    1250                 1255                 1260             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    1265                 1270                 1275             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    1280                 1285                 1290             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    1295                 1300                 1305             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    1310                 1315                 1320             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    1325                 1330                 1335             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    1340                 1345                 1350             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    1355                 1360                 1365             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    1370                 1375                 1380             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    1385                 1390                 1395             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    1400                 1405                 1410             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    1415                 1420                 1425             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    1430                 1435                 1440             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    1445                 1450                 1455             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    1460                 1465                 1470             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    1475                 1480                 1485             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    1490                 1495                 1500             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    1505                 1510                 1515             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    1520                 1525                 1530             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    1535                 1540                 1545             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    1550                 1555                 1560             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    1565                 1570                 1575             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    1580                 1585                 1590             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    1595                 1600                 1605             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    1610                 1615                 1620             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    1625                 1630                 1635             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    1640                 1645                 1650             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    1655                 1660                 1665             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    1670                 1675                 1680             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    1685                 1690                 1695             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    1700                 1705                 1710             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    1715                 1720                 1725             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    1730                 1735                 1740             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    1745                 1750                 1755             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    1760                 1765                 1770             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    1775                 1780                 1785             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    1790                 1795                 1800             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    1805                 1810                 1815             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    1820                 1825                 1830             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    1835                 1840                 1845             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    1850                 1855                 1860             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    1865                 1870                 1875             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    1880                 1885                 1890             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    1895                 1900                 1905             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    1910                 1915                 1920             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    1925                 1930                 1935             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    1940                 1945                 1950             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    1955                 1960                 1965             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    1970                 1975                 1980             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    1985                 1990                 1995             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    2000                 2005                 2010             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    2015                 2020                 2025             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    2030                 2035                 2040             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    2045                 2050                 2055             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    2060                 2065                 2070             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    2075                 2080                 2085             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    2090                 2095                 2100             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    2105                 2110                 2115             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    2120                 2125                 2130             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    2135                 2140                 2145             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    2150                 2155                 2160             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    2165                 2170                 2175             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    2180                 2185                 2190             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    2195                 2200                 2205             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    2210                 2215                 2220             


Ile Pro  Gly Ile Gly Ala Leu  Val Pro Ala Pro Val  Val Ile Ala 
    2225                 2230                 2235             


Ala Gly  Arg Thr Glu Glu Pro  Ile Ala Ile Val Ser  Met Ala Cys 
    2240                 2245                 2250             


Arg Leu  Pro Gly Gly Val Asn  Thr Pro Gln Arg Leu  Trp Glu Leu 
    2255                 2260                 2265             


Leu Arg  Glu Gly Gly Glu Thr  Leu Ser Gly Phe Pro  Thr Asp Arg 
    2270                 2275                 2280             


Gly Trp  Asp Leu Ala Arg Leu  His His Pro Asp Pro  Asp Asn Pro 
    2285                 2290                 2295             


Gly Thr  Ser Tyr Val Asp Lys  Gly Gly Phe Leu Asp  Asp Ala Ala 
    2300                 2305                 2310             


Gly Phe  Asp Ala Glu Phe Phe  Gly Val Ser Pro Arg  Glu Ala Ala 
    2315                 2320                 2325             


Ala Met  Asp Pro Gln Gln Arg  Leu Leu Leu Glu Thr  Ser Trp Glu 
    2330                 2335                 2340             


Leu Val  Glu Asn Ala Gly Ile  Asp Pro His Ser Leu  Arg Gly Thr 
    2345                 2350                 2355             


Ala Thr  Gly Val Phe Leu Gly  Val Ala Lys Phe Gly  Tyr Gly Glu 
    2360                 2365                 2370             


Asp Thr  Ala Ala Ala Glu Asp  Val Glu Gly Tyr Ser  Val Thr Gly 
    2375                 2380                 2385             


Val Ala  Pro Ala Val Ala Ser  Gly Arg Ile Ser Tyr  Thr Met Gly 
    2390                 2395                 2400             


Leu Glu  Gly Pro Ser Ile Ser  Val Asp Thr Ala Cys  Ser Ser Ser 
    2405                 2410                 2415             


Leu Val  Ala Leu His Leu Ala  Val Glu Ser Leu Arg  Lys Gly Glu 
    2420                 2425                 2430             


Ser Ser  Met Ala Val Val Gly  Gly Ala Ala Val Met  Ala Thr Pro 
    2435                 2440                 2445             


Gly Val  Phe Val Asp Phe Ser  Arg Gln Arg Ala Leu  Ala Ala Asp 
    2450                 2455                 2460             


Gly Arg  Ser Lys Ala Phe Gly  Ala Gly Ala Asp Gly  Phe Gly Phe 
    2465                 2470                 2475             


Ser Glu  Gly Val Thr Leu Val  Leu Leu Glu Arg Leu  Ser Glu Ala 
    2480                 2485                 2490             


Arg Arg  Asn Gly His Glu Val  Leu Ala Val Val Arg  Gly Ser Ala 
    2495                 2500                 2505             


Leu Asn  Gln Asp Gly Ala Ser  Asn Gly Leu Ser Ala  Pro Ser Gly 
    2510                 2515                 2520             


Pro Ala  Gln Arg Arg Val Ile  Arg Gln Ala Leu Glu  Ser Cys Gly 
    2525                 2530                 2535             


Leu Glu  Pro Gly Asp Val Asp  Ala Val Glu Ala His  Gly Thr Gly 
    2540                 2545                 2550             


Thr Ala  Leu Gly Asp Pro Ile  Glu Ala Asn Ala Leu  Leu Asp Thr 
    2555                 2560                 2565             


Tyr Gly  Arg Asp Arg Asp Ala  Asp Arg Pro Leu Trp  Leu Gly Ser 
    2570                 2575                 2580             


Val Lys  Ser Asn Ile Gly His  Thr Gln Ala Ala Ala  Gly Val Thr 
    2585                 2590                 2595             


Gly Leu  Leu Lys Val Val Leu  Ala Leu Arg Asn Gly  Glu Leu Pro 
    2600                 2605                 2610             


Ala Thr  Leu His Val Glu Glu  Pro Thr Pro His Val  Asp Trp Ser 
    2615                 2620                 2625             


Ser Gly  Gly Val Ala Leu Leu  Ala Gly Asn Gln Pro  Trp Arg Arg 
    2630                 2635                 2640             


Gly Glu  Arg Thr Arg Arg Ala  Ala Val Ser Ala Phe  Gly Ile Ser 
    2645                 2650                 2655             


Gly Thr  Asn Ala His Val Ile  Val Glu Glu Ala Pro  Gln Glu Val 
    2660                 2665                 2670             


Arg Pro  Ala Pro Gly Gln Gly  Leu Ser Pro Ala Val  Ser Thr Leu 
    2675                 2680                 2685             


Val Val  Ala Gly Lys Thr Met  Gln Arg Val Ser Ala  Thr Ala Gly 
    2690                 2695                 2700             


Met Leu  Ala Asp Trp Met Glu  Gly Pro Gly Ala Asp  Val Ala Leu 
    2705                 2710                 2715             


Ala Asp  Val Ala His Thr Leu  Asn His His Arg Ser  Arg Gln Pro 
    2720                 2725                 2730             


Lys Phe  Gly Thr Val Val Ala  Arg Asp Arg Thr Gln  Ala Ile Ala 
    2735                 2740                 2745             


Gly Leu  Arg Ala Leu Ala Ala  Gly Gln His Ala Pro  Gly Val Val 
    2750                 2755                 2760             


Asn Pro  Ala Glu Gly Ser Pro  Gly Pro Gly Thr Val  Phe Val Phe 
    2765                 2770                 2775             


Pro Gly  Gln Gly Ser Gln Arg  Ala Gly Met Gly Glu  Glu Leu Ala 
    2780                 2785                 2790             


Ala Ala  Phe Pro Val Phe Ala  Arg Ile His Gln Gln  Val Trp Asp 
    2795                 2800                 2805             


Leu Leu  Asp Val Pro Asp Leu  Asp Val Asn Glu Thr  Gly Tyr Ala 
    2810                 2815                 2820             


Gln Pro  Ala Leu Phe Ala Leu  Gln Val Ala Leu Phe  Gly Leu Leu 
    2825                 2830                 2835             


Glu Ser  Trp Gly Val Arg Pro  Asp Ala Val Val Gly  His Ser Val 
    2840                 2845                 2850             


Gly Glu  Leu Ala Ala Gly Tyr  Val Ser Gly Leu Trp  Ser Leu Glu 
    2855                 2860                 2865             


Asp Ala  Cys Thr Leu Val Ser  Ala Arg Ala Arg Leu  Met Gln Ala 
    2870                 2875                 2880             


Leu Pro  Ala Gly Gly Val Met  Ala Ala Val Pro Val  Ser Glu Asp 
    2885                 2890                 2895             


Glu Ala  Arg Ala Val Leu Gly  Glu Gly Val Glu Ile  Ala Ala Val 
    2900                 2905                 2910             


Asn Gly  Pro Ser Ser Val Val  Leu Ser Gly Asp Glu  Ala Ala Val 
    2915                 2920                 2925             


Leu Gln  Ala Ala Glu Gly Leu  Gly Lys Trp Thr Arg  Leu Pro Thr 
    2930                 2935                 2940             


Ser His  Ala Phe His Ser Ala  Arg Met Glu Pro Met  Leu Glu Glu 
    2945                 2950                 2955             


Phe Arg  Ala Val Ala Glu Gly  Leu Thr Tyr Arg Thr  Pro Gln Val 
    2960                 2965                 2970             


Ala Met  Ala Ala Gly Asp Gln  Val Met Thr Ala Glu  Tyr Trp Val 
    2975                 2980                 2985             


Arg Gln  Val Arg Asp Thr Val  Arg Phe Gly Glu Gln  Val Ala Ser 
    2990                 2995                 3000             


Phe Glu  Asp Ala Val Phe Val  Glu Leu Gly Ala Asp  Arg Ser Leu 
    3005                 3010                 3015             


Ala Arg  Leu Val Asp Gly Ile  Ala Met Leu His Gly  Asp His Glu 
    3020                 3025                 3030             


Ala Gln  Ala Gly Met Arg Arg  Glu Gln Pro Leu Pro  Leu Gly Leu 
    3035                 3040                 3045             


Arg Arg  Leu Leu Thr Asp Leu  His Asn Ala Gly Ala  Ala Val Asp 
    3050                 3055                 3060             


Phe Ser  Val Leu Cys Pro Gln  Gly Arg Leu Val Asp  Ala Pro Leu 
    3065                 3070                 3075             


Pro Ala  Trp Ser His Arg Phe  Leu Phe Tyr Asp Arg  Glu Gly Val 
    3080                 3085                 3090             


Asp Asn  Arg Ser Pro Gly Gly  Ser Thr Val Ala Val  His Pro Leu 
    3095                 3100                 3105             


Leu Leu  Ala Ala Val Asp Val  Pro Gly His Gly Gly  Ala Val Phe 
    3110                 3115                 3120             


Thr Gly  Arg Leu Ser Thr Asp  Glu Gln Pro Trp Leu  Ala Glu His 
    3125                 3130                 3135             


Val Val  Gly Gly Arg Thr Leu  Val Pro Gly Ser Val  Leu Val Asp 
    3140                 3145                 3150             


Leu Ala  Leu Ala Ala Gly Glu  Asp Val Gly Leu Pro  Val Leu Glu 
    3155                 3160                 3165             


Glu Leu  Val Leu Gln Arg Pro  Leu Val Leu Ala Gly  Ala Gly Ala 
    3170                 3175                 3180             


Leu Leu  Arg Met Ser Val Gly  Ala Pro Asp Glu Ser  Gly Arg Arg 
    3185                 3190                 3195             


Thr Ile  Asp Val His Ala Ala  Glu Asp Val Ala Asp  Leu Ala Asp 
    3200                 3205                 3210             


Ala Gln  Trp Ser Gln His Ala  Thr Gly Thr Leu Ala  Gln Gly Val 
    3215                 3220                 3225             


Ala Ala  Gly Pro Arg Asp Thr  Glu Gln Trp Pro Pro  Glu Asp Ala 
    3230                 3235                 3240             


Val Arg  Ile Pro Leu Asp Asp  His Tyr Asp Gly Leu  Ala Glu Gln 
    3245                 3250                 3255             


Gly Tyr  Glu Tyr Gly Pro Ser  Phe Gln Ala Leu Val  Ala Tyr Val 
    3260                 3265                 3270             


Ala Glu  Asp Ala Thr Ala Thr  Met Leu Ala Glu Val  Ala Leu Pro 
    3275                 3280                 3285             


Gly Ser  Ile Arg Ser Gln Gln  Gly Leu Tyr Ala Ile  His Pro Ala 
    3290                 3295                 3300             


Leu Leu  Asp Ala Cys Phe Gln  Ser Val Gly Ala His  Pro Asp Ser 
    3305                 3310                 3315             


Gln Ser  Val Gly Ser Gly Leu  Leu Val Pro Leu Gly  Val Arg Arg 
    3320                 3325                 3330             


Val Arg  Ala Tyr Ala Pro Val  Arg Thr Ala Arg Tyr  Cys Tyr Thr 
    3335                 3340                 3345             


Arg Val  Thr Lys Val Glu Leu  Ala Gly Val Glu Ala  Asp Ile Asp 
    3350                 3355                 3360             


Val Leu  Asp Ala His Gly Thr  Val Leu Leu Ala Val  Cys Gly Leu 
    3365                 3370                 3375             


Arg Ile  Gly Thr Gly Val Ser  Glu Arg Asp Lys His  Asn Arg Val 
    3380                 3385                 3390             


Leu Asn  Glu Arg Leu Leu Thr  Ile Glu Trp His Gln  Arg Glu Leu 
    3395                 3400                 3405             


Pro Glu  Met Asp Pro Ser Gly  Ala Gly Lys Trp Leu  Leu Ile Ser 
    3410                 3415                 3420             


Asp Cys  Ala Ala Ser Asp Val  Thr Ala Thr Arg Leu  Ala Asp Ala 
    3425                 3430                 3435             


Phe Arg  Glu His Ser Ala Ala  Cys Thr Thr Met Arg  Trp Pro Leu 
    3440                 3445                 3450             


His Asp  Asp Gln Leu Ala Ala  Ala Asp Gln Leu Arg  Asp Gln Val 
    3455                 3460                 3465             


Gly Ser  Asp Glu Phe Ser Gly  Val Val Val Leu Thr  Gly Pro Asn 
    3470                 3475                 3480             


Thr Gly  Thr Pro His Gln Gly  Ser Ala Asp Arg Gly  Ala Glu Tyr 
    3485                 3490                 3495             


Val Arg  Arg Leu Val Gly Ile  Ala Arg Glu Leu Ser  Asp Leu Pro 
    3500                 3505                 3510             


Gly Ala  Val Pro Arg Met Tyr  Val Val Thr Arg Gly  Ala Gln Arg 
    3515                 3520                 3525             


Val Leu  Ala Asp Asp Cys Val  Asn Leu Glu Gln Gly  Gly Leu Arg 
    3530                 3535                 3540             


Gly Leu  Leu Arg Thr Ile Gly  Ala Glu His Pro His  Leu Arg Ala 
    3545                 3550                 3555             


Thr Gln  Ile Asp Val Asp Glu  Gln Thr Gly Val Glu  Gln Leu Ala 
    3560                 3565                 3570             


Arg Gln  Leu Leu Ala Thr Ser  Glu Glu Asp Glu Thr  Ala Trp Arg 
    3575                 3580                 3585             


Asp Asn  Glu Trp Tyr Val Ala  Arg Leu Cys Pro Thr  Pro Leu Arg 
    3590                 3595                 3600             


Pro Gln  Glu Arg Arg Thr Ile  Val Ala Asp His Gln  Gln Ser Gly 
    3605                 3610                 3615             


Met Arg  Leu Gln Ile Arg Thr  Pro Gly Ala Ile Asp  Ser Val Ala 
    3620                 3625                 3630             


Phe Glu  Pro Ala Pro Asp Val  Glu Gln Pro Leu Arg  Ala Gly Glu 
    3635                 3640                 3645             


Val Arg  Val Asp Val Arg Ala  Thr Gly Val Asn Phe  Arg Asp Val 
    3650                 3655                 3660             


Leu Leu  Ala Leu Gly Met Tyr  Pro Gln Lys Ala Asp  Met Gly Thr 
    3665                 3670                 3675             


Glu Ala  Ala Gly Val Val Thr  Ala Val Gly Pro Asp  Val Asp Ala 
    3680                 3685                 3690             


Phe Ala  Pro Gly Asp Arg Val  Leu Gly Leu Phe Gln  Gly Ala Phe 
    3695                 3700                 3705             


Ala Pro  Ile Ala Val Thr Asp  His Arg Leu Leu Ala  Arg Val Pro 
    3710                 3715                 3720             


Asp Gly  Trp Ser Asp Ala Asp  Ala Ala Ala Val Pro  Ile Ala Tyr 
    3725                 3730                 3735             


Thr Thr  Ala His Tyr Ala Leu  His Asp Leu Ala Gly  Leu Arg Ala 
    3740                 3745                 3750             


Gly Gln  Ser Val Leu Ile His  Ala Ala Ala Gly Gly  Val Gly Met 
    3755                 3760                 3765             


Ala Ala  Val Ala Leu Ala Arg  Arg Ala Gly Ala Glu  Val Leu Ala 
    3770                 3775                 3780             


Thr Ala  Gly Pro Ala Lys His  Gly Thr Leu Arg Ala  Leu Gly Leu 
    3785                 3790                 3795             


Asp Asp  Glu His Ile Ala Ser  Ser Arg Glu Thr Gly  Phe Ala Arg 
    3800                 3805                 3810             


Lys Phe  Arg Glu Arg Thr Gly  Gly Arg Gly Val Asp  Val Val Leu 
    3815                 3820                 3825             


Asn Ser  Leu Thr Gly Glu Leu  Leu Asp Glu Ser Ala  Asp Leu Leu 
    3830                 3835                 3840             


Ala Glu  Asp Gly Val Phe Val  Glu Met Gly Lys Thr  Asp Leu Arg 
    3845                 3850                 3855             


Asp Ala  Gly Asp Phe Arg Gly  Arg Tyr Ala Pro Phe  Asp Leu Gly 
    3860                 3865                 3870             


Glu Ala  Gly Asp Asp Arg Leu  Gly Glu Ile Leu Arg  Glu Val Val 
    3875                 3880                 3885             


Gly Leu  Leu Gly Ala Gly Glu  Leu Asp Arg Leu Pro  Val Ser Ala 
    3890                 3895                 3900             


Trp Glu  Leu Gly Ile Pro Gln  Thr Gly Lys Ser Leu  Val Thr Leu 
    3905                 3910                 3915             


Pro Pro  Glu Gln Ala Gln Val  Phe Arg Pro Asp Gly  Thr Val Leu 
    3920                 3925                 3930             


Ile Thr  Gly Gly Thr Gly Thr  Leu Gly Arg Leu Leu  Ala Arg His 
    3935                 3940                 3945             


Leu Val  Thr Glu His Gly Val  Arg His Leu Leu Leu  Val Ser Arg 
    3950                 3955                 3960             


Arg Gly  Ala Asp Ala Pro Gly  Ser Asp Glu Leu Arg  Ala Glu Ile 
    3965                 3970                 3975             


Glu Asp  Leu Gly Ala Ser Ala  Glu Ile Ala Ala Cys  Asp Thr Ala 
    3980                 3985                 3990             


Asp Arg  Asp Ala Leu Ser Ala  Leu Leu Asp Gly Leu  Pro Arg Pro 
    3995                 4000                 4005             


Leu Thr  Gly Val Val His Ala  Ala Gly Val Leu Ala  Asp Gly Leu 
    4010                 4015                 4020             


Val Thr  Ser Ile Asp Glu Pro  Ala Val Glu Gln Val  Leu Arg Ala 
    4025                 4030                 4035             


Lys Val  Asp Ala Ala Trp Asn  Leu His Glu Leu Thr  Ala Asn Thr 
    4040                 4045                 4050             


Gly Leu  Ser Phe Phe Val Leu  Phe Ser Ser Ala Ala  Ser Val Leu 
    4055                 4060                 4065             


Ala Gly  Pro Gly Gln Gly Val  Tyr Ala Ala Ala Asn  Glu Ser Leu 
    4070                 4075                 4080             


Asn Ala  Leu Ala Ala Leu Arg  Arg Thr Arg Gly Leu  Pro Ala Lys 
    4085                 4090                 4095             


Ala Leu  Gly Trp Gly Leu Trp  Ala Ile Gly Arg Ala  Ile Ala Phe 
    4100                 4105                 4110             


Ala Glu  Gln Thr Gly Asp Ala  Ile Ala Pro Glu Glu  Gly Ala Tyr 
    4115                 4120                 4125             


Ala Phe  Glu Thr Leu Leu Arg  His Asn Arg Ala Tyr  Ser Gly Tyr 
    4130                 4135                 4140             


Ala Pro  Val Ile Gly Ser Pro  Trp Leu Thr Ala Phe  Ala Gln His 
    4145                 4150                 4155             


Ser Pro  Phe Ala Glu Lys Phe  Gln Ser Leu Gly Gln  Asn Arg Ser 
    4160                 4165                 4170             


Gly Thr  Ser Lys Phe Leu Ala  Glu Leu Val Asp Leu  Pro Arg Glu 
    4175                 4180                 4185             


Glu Trp  Pro Asp Arg Leu Arg  Arg Leu Leu Glu Leu  Val Arg Ser 
    4190                 4195                 4200             


His Ala  Ala Ala Val Ser Gly  Tyr Gly Ser Ala Asp  Gln Leu Pro 
    4205                 4210                 4215             


Glu Arg  Lys Ala Phe Lys Asp  Leu Gly Phe Asp Ser  Leu Ala Ala 
    4220                 4225                 4230             


Val Glu  Leu Arg Asn Arg Leu  Gly Thr Ala Thr Gly  Val Arg Leu 
    4235                 4240                 4245             


Pro Ser  Thr Leu Val Phe Asp  His Pro Thr Pro Leu  Ala Val Ala 
    4250                 4255                 4260             


Glu His  Leu Arg Asp Arg Leu  Thr Ser Gly Glu Asp  Asn Pro Ile 
    4265                 4270                 4275             


Pro Leu  Cys Gln Gly Asp Gly  Glu Glu Met Ser Thr  Trp Leu Arg 
    4280                 4285                 4290             


Arg Phe  Gly Pro Pro Val Glu  His Arg Ala Arg Leu  Val Cys Phe 
    4295                 4300                 4305             


Pro His  Ala Gly Ala Ala Ala  Asp Ser Tyr Leu Asp  Leu Ala Arg 
    4310                 4315                 4320             


Ala Leu  Ala Pro Glu Ile Asp  Val His Ala Val Gln  Tyr Pro Gly 
    4325                 4330                 4335             


Arg Gln  Asp Arg Arg Asp Glu  Glu Pro Leu Gly Thr  Ala Gly Glu 
    4340                 4345                 4350             


Ile Ala  Asp Glu Val Ala Ala  Val Leu Arg Ala Ser  Gly Gly Asp 
    4355                 4360                 4365             


Gly Pro  Phe Ala Leu Phe Gly  His Ser Met Gly Ala  Leu Ile Ala 
    4370                 4375                 4380             


Tyr Glu  Thr Ala Arg Arg Leu  Glu Arg Glu Pro Gly  Gly Gly Pro 
    4385                 4390                 4395             


Leu Arg  Leu Phe Val Ser Gly  Gln Thr Ala Pro Arg  Val His Glu 
    4400                 4405                 4410             


Arg Arg  Thr Asp Leu Pro Gly  Asp Asp Gly Leu Val  Asp Glu Leu 
    4415                 4420                 4425             


Arg Arg  Leu Gly Thr Ser Glu  Ala Ala Leu Ala Asp  Glu Ala Leu 
    4430                 4435                 4440             


Leu Ala  Met Ser Leu Pro Val  Leu Arg Ala Asp Tyr  Arg Val Leu 
    4445                 4450                 4455             


Arg Ser  Tyr Ala Trp Ala Asp  Gly Pro Pro Leu Arg  Ala Gly Ile 
    4460                 4465                 4470             


Thr Ala  Leu Cys Gly Asp Ala  Asp Pro Leu Thr Ala  Thr Gly Asp 
    4475                 4480                 4485             


Ala Glu  Arg Trp Leu Gln His  Ser Val Ile Pro Gly  Arg Thr Arg 
    4490                 4495                 4500             


Thr Phe  Pro Gly Gly His Phe  Tyr Leu Gly Glu Gln  Val Thr Glu 
    4505                 4510                 4515             


Val Ala  Gly Ala Val Arg Arg  Asp Leu Leu Arg Ala  Gly Leu Ala 
    4520                 4525                 4530             


Gly 
    


<210>  47
<211>  3983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISO

<400>  47

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gln His Leu 
    1160                 1165                 1170             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    1175                 1180                 1185             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    1190                 1195                 1200             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    1205                 1210                 1215             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    1220                 1225                 1230             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    1235                 1240                 1245             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    1250                 1255                 1260             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    1265                 1270                 1275             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    1280                 1285                 1290             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    1295                 1300                 1305             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    1310                 1315                 1320             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    1325                 1330                 1335             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    1340                 1345                 1350             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    1355                 1360                 1365             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    1370                 1375                 1380             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    1385                 1390                 1395             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    1400                 1405                 1410             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    1415                 1420                 1425             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    1430                 1435                 1440             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    1445                 1450                 1455             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    1460                 1465                 1470             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    1475                 1480                 1485             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    1490                 1495                 1500             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    1505                 1510                 1515             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    1520                 1525                 1530             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    1535                 1540                 1545             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    1550                 1555                 1560             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    1565                 1570                 1575             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    1580                 1585                 1590             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    1595                 1600                 1605             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    1610                 1615                 1620             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    1625                 1630                 1635             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    1640                 1645                 1650             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    1655                 1660                 1665             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    1670                 1675                 1680             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    1685                 1690                 1695             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    1700                 1705                 1710             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    1715                 1720                 1725             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    1730                 1735                 1740             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    1745                 1750                 1755             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    1760                 1765                 1770             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    1775                 1780                 1785             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    1790                 1795                 1800             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    1805                 1810                 1815             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    1820                 1825                 1830             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    1835                 1840                 1845             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    1850                 1855                 1860             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    1865                 1870                 1875             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    1880                 1885                 1890             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    1895                 1900                 1905             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    1910                 1915                 1920             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    1925                 1930                 1935             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    1940                 1945                 1950             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    1955                 1960                 1965             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    1970                 1975                 1980             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    1985                 1990                 1995             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    2000                 2005                 2010             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    2015                 2020                 2025             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    2030                 2035                 2040             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    2045                 2050                 2055             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    2060                 2065                 2070             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    2075                 2080                 2085             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    2090                 2095                 2100             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    2105                 2110                 2115             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    2120                 2125                 2130             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    2135                 2140                 2145             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    2150                 2155                 2160             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    2165                 2170                 2175             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    2180                 2185                 2190             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    2195                 2200                 2205             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    2210                 2215                 2220             


Ile Pro  Gly Ile Gly Ala Leu  Val Pro Ala Pro Val  Val Ile Ala 
    2225                 2230                 2235             


Ala Gly  Arg Thr Glu Glu Pro  Ile Ala Ile Val Ser  Met Ala Cys 
    2240                 2245                 2250             


Arg Leu  Pro Gly Gly Val Asn  Thr Pro Gln Arg Leu  Trp Glu Leu 
    2255                 2260                 2265             


Leu Arg  Glu Gly Gly Glu Thr  Leu Ser Gly Phe Pro  Thr Asp Arg 
    2270                 2275                 2280             


Gly Trp  Asp Leu Ala Arg Leu  His His Pro Asp Pro  Asp Asn Pro 
    2285                 2290                 2295             


Gly Thr  Ser Tyr Val Asp Lys  Gly Gly Phe Leu Asp  Asp Ala Ala 
    2300                 2305                 2310             


Gly Phe  Asp Ala Glu Phe Phe  Gly Val Ser Pro Arg  Glu Ala Ala 
    2315                 2320                 2325             


Ala Met  Asp Pro Gln Gln Arg  Leu Leu Leu Glu Thr  Ser Trp Glu 
    2330                 2335                 2340             


Leu Val  Glu Asn Ala Gly Ile  Asp Pro His Ser Leu  Arg Gly Thr 
    2345                 2350                 2355             


Ala Thr  Gly Val Phe Leu Gly  Val Ala Lys Phe Gly  Tyr Gly Glu 
    2360                 2365                 2370             


Asp Thr  Ala Ala Ala Glu Asp  Val Glu Gly Tyr Ser  Val Thr Gly 
    2375                 2380                 2385             


Val Ala  Pro Ala Val Ala Ser  Gly Arg Ile Ser Tyr  Thr Met Gly 
    2390                 2395                 2400             


Leu Glu  Gly Pro Ser Ile Ser  Val Asp Thr Ala Cys  Ser Ser Ser 
    2405                 2410                 2415             


Leu Val  Ala Leu His Leu Ala  Val Glu Ser Leu Arg  Lys Gly Glu 
    2420                 2425                 2430             


Ser Ser  Met Ala Val Val Gly  Gly Ala Ala Val Met  Ala Thr Pro 
    2435                 2440                 2445             


Gly Val  Phe Val Asp Phe Ser  Arg Gln Arg Ala Leu  Ala Ala Asp 
    2450                 2455                 2460             


Gly Arg  Ser Lys Ala Phe Gly  Ala Gly Ala Asp Gly  Phe Gly Phe 
    2465                 2470                 2475             


Ser Glu  Gly Val Thr Leu Val  Leu Leu Glu Arg Leu  Ser Glu Ala 
    2480                 2485                 2490             


Arg Arg  Asn Gly His Glu Val  Leu Ala Val Val Arg  Gly Ser Ala 
    2495                 2500                 2505             


Leu Asn  Gln Asp Gly Ala Ser  Asn Gly Leu Ser Ala  Pro Ser Gly 
    2510                 2515                 2520             


Pro Ala  Gln Arg Arg Val Ile  Arg Gln Ala Leu Glu  Ser Cys Gly 
    2525                 2530                 2535             


Leu Glu  Pro Gly Asp Val Asp  Ala Val Glu Ala His  Gly Thr Gly 
    2540                 2545                 2550             


Thr Ala  Leu Gly Asp Pro Ile  Glu Ala Asn Ala Leu  Leu Asp Thr 
    2555                 2560                 2565             


Tyr Gly  Arg Asp Arg Asp Ala  Asp Arg Pro Leu Trp  Leu Gly Ser 
    2570                 2575                 2580             


Val Lys  Ser Asn Ile Gly His  Thr Gln Ala Ala Ala  Gly Val Thr 
    2585                 2590                 2595             


Gly Leu  Leu Lys Val Val Leu  Ala Leu Arg Asn Gly  Glu Leu Pro 
    2600                 2605                 2610             


Ala Thr  Leu His Val Glu Glu  Pro Thr Pro His Val  Asp Trp Ser 
    2615                 2620                 2625             


Ser Gly  Gly Val Ala Leu Leu  Ala Gly Asn Gln Pro  Trp Arg Arg 
    2630                 2635                 2640             


Gly Glu  Arg Thr Arg Arg Ala  Ala Val Ser Ala Phe  Gly Ile Ser 
    2645                 2650                 2655             


Gly Thr  Asn Ala His Val Ile  Val Glu Glu Ala Pro  Gln Glu Val 
    2660                 2665                 2670             


Arg Pro  Ala Pro Gly Gln Gly  Leu Ser Pro Ala Val  Ser Thr Leu 
    2675                 2680                 2685             


Val Val  Ala Gly Lys Thr Met  Gln Arg Val Ser Ala  Thr Ala Gly 
    2690                 2695                 2700             


Met Leu  Ala Asp Trp Met Glu  Gly Pro Gly Ala Asp  Val Ala Leu 
    2705                 2710                 2715             


Ala Asp  Val Ala His Thr Leu  Asn His His Arg Ser  Arg Gln Pro 
    2720                 2725                 2730             


Lys Phe  Gly Thr Val Val Ala  Arg Asp Arg Thr Gln  Ala Ile Ala 
    2735                 2740                 2745             


Gly Leu  Arg Ala Leu Ala Ala  Gly Gln His Ala Pro  Gly Val Val 
    2750                 2755                 2760             


Asn Pro  Ala Glu Gly Ser Pro  Gly Pro Gly Thr Val  Phe Val Phe 
    2765                 2770                 2775             


Pro Gly  Gln Gly Ser Gln Arg  Ala Gly Met Gly Glu  Glu Leu Ala 
    2780                 2785                 2790             


Ala Ala  Phe Pro Val Phe Ala  Arg Ile His Gln Gln  Val Trp Asp 
    2795                 2800                 2805             


Leu Leu  Asp Val Pro Asp Leu  Asp Val Asn Glu Thr  Gly Tyr Ala 
    2810                 2815                 2820             


Gln Pro  Ala Leu Phe Ala Leu  Gln Val Ala Leu Phe  Gly Leu Leu 
    2825                 2830                 2835             


Glu Ser  Trp Gly Val Arg Pro  Asp Ala Val Val Gly  His Ser Val 
    2840                 2845                 2850             


Gly Glu  Leu Ala Ala Gly Tyr  Val Ser Gly Leu Trp  Ser Leu Glu 
    2855                 2860                 2865             


Asp Ala  Cys Thr Leu Val Ser  Ala Arg Ala Arg Leu  Met Gln Ala 
    2870                 2875                 2880             


Leu Pro  Ala Gly Gly Val Met  Ala Ala Val Pro Val  Ser Glu Asp 
    2885                 2890                 2895             


Glu Ala  Arg Ala Val Leu Gly  Glu Gly Val Glu Ile  Ala Ala Val 
    2900                 2905                 2910             


Asn Gly  Pro Ser Ser Val Val  Leu Ser Gly Asp Glu  Ala Ala Val 
    2915                 2920                 2925             


Leu Gln  Ala Ala Glu Gly Leu  Gly Lys Trp Thr Arg  Leu Pro Thr 
    2930                 2935                 2940             


Ser His  Ala Phe His Ser Ala  Arg Met Glu Pro Met  Leu Glu Glu 
    2945                 2950                 2955             


Phe Arg  Ala Val Ala Glu Gly  Leu Thr Tyr Arg Thr  Pro Gln Val 
    2960                 2965                 2970             


Ala Met  Ala Ala Gly Asp Gln  Val Met Thr Ala Glu  Tyr Trp Val 
    2975                 2980                 2985             


Arg Gln  Val Arg Asp Thr Val  Arg Phe Gly Glu Gln  Val Ala Ser 
    2990                 2995                 3000             


Phe Glu  Asp Ala Val Phe Val  Glu Leu Gly Ala Asp  Arg Ser Leu 
    3005                 3010                 3015             


Ala Arg  Leu Val Asp Gly Ile  Ala Met Leu His Gly  Asp His Glu 
    3020                 3025                 3030             


Ala Gln  Ala Ala Asp His Arg  Gln Ile Thr Glu Ala  Val Ala Asp 
    3035                 3040                 3045             


Ala Tyr  Val Leu Gly His Leu  Pro Asp Phe Ala Ala  Leu Arg Arg 
    3050                 3055                 3060             


Pro His  Ala Arg Lys Leu Asp  Leu Pro Thr Tyr Pro  Phe Glu Arg 
    3065                 3070                 3075             


Arg Gln  Tyr Trp Phe Arg Asp  Ala Arg Glu Arg Pro  Glu Gln Pro 
    3080                 3085                 3090             


Arg Asp  Thr Gly Gly Pro Arg  Thr Glu Ala Val Arg  Leu Leu Glu 
    3095                 3100                 3105             


Asp Gly  Arg Ile Glu Glu Leu  Ala Ala Leu Leu Gly  Gly Ala Ser 
    3110                 3115                 3120             


Asp Asp  Gln His Thr Leu Gln  Val Leu Thr Lys Leu  Ala Ala Gln 
    3125                 3130                 3135             


His Asn  Gln Gln Arg Thr Thr  Arg Ser Ile Ala Asp  Asp Arg Tyr 
    3140                 3145                 3150             


Glu Ile  Arg Trp Asp Arg Ser  Thr Ser Pro Leu Ser  Gly Ala Asp 
    3155                 3160                 3165             


Val Asp  Gln Ala Gly Ser Trp  Ile Val Val Ser Asp  Asp Ala Asp 
    3170                 3175                 3180             


Ala Val  Pro Pro Leu Val Asp  Leu Leu Ala Ala Arg  Asn Glu Pro 
    3185                 3190                 3195             


His Gln  Val Val Gly Leu Pro  Ala Ser Asp Ala Asp  Glu Glu Arg 
    3200                 3205                 3210             


Leu Ala  Glu Thr Leu Arg Ala  Ala Ala Thr Glu Asp  Ala Thr Leu 
    3215                 3220                 3225             


Arg Ile  Val His Val Ala Ala  Leu Glu Ala Gly Ala  Thr Pro Ser 
    3230                 3235                 3240             


Met Arg  Ser Leu Leu Arg Met  Gln His Arg Ile Leu  Gly Gly Thr 
    3245                 3250                 3255             


Arg Arg  Val Phe Arg Ala Ala  Val Ala Ala Glu Leu  Arg Gly Pro 
    3260                 3265                 3270             


Ile Trp  Ile Val Thr Arg Gly  Ala Gln Arg Val Ala  Asp Thr Asp 
    3275                 3280                 3285             


Thr Val  Ala Pro His Gln Ser  Cys Leu Trp Gly Phe  Gly Arg Ala 
    3290                 3295                 3300             


Ala Ser  Leu Glu Leu Pro His  Val Trp Gly Gly Leu  Ala Asp Leu 
    3305                 3310                 3315             


Ser Glu  Gly Gly Asp Asn Ala  Ala Asp Glu Trp Ser  Ala Leu Val 
    3320                 3325                 3330             


Asp Arg  Ile Ala Ala Pro His  Gly Ser Ala Val Arg  Glu Asp Gln 
    3335                 3340                 3345             


Leu Ala  Leu Arg Asp Arg Ala  Val Tyr Thr Pro Arg  Leu Ala Arg 
    3350                 3355                 3360             


Arg Ser  Ala Pro Pro Ser Gly  Thr Pro Leu His Leu  Arg Gly Asp 
    3365                 3370                 3375             


Gly Thr  Val Leu Ile Thr Gly  Gly Thr Gly Thr Leu  Gly Arg Leu 
    3380                 3385                 3390             


Leu Ala  Arg His Leu Val Thr  Glu His Gly Val Arg  His Leu Leu 
    3395                 3400                 3405             


Leu Val  Ser Arg Arg Gly Ala  Asp Ala Pro Gly Ser  Asp Glu Leu 
    3410                 3415                 3420             


Arg Ala  Glu Ile Glu Asp Leu  Gly Ala Ser Ala Glu  Ile Ala Ala 
    3425                 3430                 3435             


Cys Asp  Thr Ala Asp Arg Asp  Ala Leu Ser Ala Leu  Leu Asp Gly 
    3440                 3445                 3450             


Leu Pro  Arg Pro Leu Thr Gly  Val Val His Ala Ala  Gly Val Leu 
    3455                 3460                 3465             


Ala Asp  Gly Leu Val Thr Ser  Ile Asp Glu Pro Ala  Val Glu Gln 
    3470                 3475                 3480             


Val Leu  Arg Ala Lys Val Asp  Ala Ala Trp Asn Leu  His Glu Leu 
    3485                 3490                 3495             


Thr Ala  Asn Thr Gly Leu Ser  Phe Phe Val Leu Phe  Ser Ser Ala 
    3500                 3505                 3510             


Ala Ser  Val Leu Ala Gly Pro  Gly Gln Gly Val Tyr  Ala Ala Ala 
    3515                 3520                 3525             


Asn Glu  Ser Leu Asn Ala Leu  Ala Ala Leu Arg Arg  Thr Arg Gly 
    3530                 3535                 3540             


Leu Pro  Ala Lys Ala Leu Gly  Trp Gly Leu Trp Ala  Ile Gly Arg 
    3545                 3550                 3555             


Ala Ile  Ala Phe Ala Glu Gln  Thr Gly Asp Ala Ile  Ala Pro Glu 
    3560                 3565                 3570             


Glu Gly  Ala Tyr Ala Phe Glu  Thr Leu Leu Arg His  Asn Arg Ala 
    3575                 3580                 3585             


Tyr Ser  Gly Tyr Ala Pro Val  Ile Gly Ser Pro Trp  Leu Thr Ala 
    3590                 3595                 3600             


Phe Ala  Gln His Ser Pro Phe  Ala Glu Lys Phe Gln  Ser Leu Gly 
    3605                 3610                 3615             


Gln Asn  Arg Ser Gly Thr Ser  Lys Phe Leu Ala Glu  Leu Val Asp 
    3620                 3625                 3630             


Leu Pro  Arg Glu Glu Trp Pro  Asp Arg Leu Arg Arg  Leu Leu Glu 
    3635                 3640                 3645             


Leu Val  Arg Ser His Ala Ala  Ala Val Ser Gly Tyr  Gly Ser Ala 
    3650                 3655                 3660             


Asp Gln  Leu Pro Glu Arg Lys  Ala Phe Lys Asp Leu  Gly Phe Asp 
    3665                 3670                 3675             


Ser Leu  Ala Ala Val Glu Leu  Arg Asn Arg Leu Gly  Thr Ala Thr 
    3680                 3685                 3690             


Gly Val  Arg Leu Pro Ser Thr  Leu Val Phe Asp His  Pro Thr Pro 
    3695                 3700                 3705             


Leu Ala  Val Ala Glu His Leu  Arg Asp Arg Leu Thr  Ser Gly Glu 
    3710                 3715                 3720             


Asp Asn  Pro Ile Pro Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser 
    3725                 3730                 3735             


Thr Trp  Leu Arg Arg Phe Gly  Pro Pro Val Glu His  Arg Ala Arg 
    3740                 3745                 3750             


Leu Val  Cys Phe Pro His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu 
    3755                 3760                 3765             


Asp Leu  Ala Arg Ala Leu Ala  Pro Glu Ile Asp Val  His Ala Val 
    3770                 3775                 3780             


Gln Tyr  Pro Gly Arg Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly 
    3785                 3790                 3795             


Thr Ala  Gly Glu Ile Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala 
    3800                 3805                 3810             


Ser Gly  Gly Asp Gly Pro Phe  Ala Leu Phe Gly His  Ser Met Gly 
    3815                 3820                 3825             


Ala Leu  Ile Ala Tyr Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro 
    3830                 3835                 3840             


Gly Gly  Gly Pro Leu Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro 
    3845                 3850                 3855             


Arg Val  His Glu Arg Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu 
    3860                 3865                 3870             


Val Asp  Glu Leu Arg Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala 
    3875                 3880                 3885             


Asp Glu  Ala Leu Leu Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp 
    3890                 3895                 3900             


Tyr Arg  Val Leu Arg Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu 
    3905                 3910                 3915             


Arg Ala  Gly Ile Thr Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr 
    3920                 3925                 3930             


Ala Thr  Gly Asp Ala Glu Arg  Trp Leu Gln His Ser  Val Ile Pro 
    3935                 3940                 3945             


Gly Arg  Thr Arg Thr Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu 
    3950                 3955                 3960             


Gln Val  Thr Glu Val Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg 
    3965                 3970                 3975             


Ala Gly  Leu Ala Gly 
    3980             


<210>  48
<211>  4096
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISS

<400>  48

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Val Pro Val Glu Gln Pro Phe Val His Ser Pro 
    610                 615                 620                 


Glu Asp Arg Tyr Gln Pro Phe Ala Leu Thr Asp Val Gln Gln Ala Tyr 
625                 630                 635                 640 


Leu Val Gly Arg Gln Pro Gly Phe Ala Leu Gly Gly Val Gly Ser His 
                645                 650                 655     


Phe Phe Val Glu Phe Glu Ile Ala Asp Leu Asp Leu Thr Arg Leu Glu 
            660                 665                 670         


Thr Val Trp Asn Arg Leu Ile Ala Arg His Asp Met Leu Arg Ala Ile 
        675                 680                 685             


Val Arg Asp Gly Gln Gln Gln Val Leu Glu Gln Thr Pro Pro Trp Val 
    690                 695                 700                 


Ile Pro Ala His Thr Leu His Thr Pro Glu Glu Ala Leu Arg Val Arg 
705                 710                 715                 720 


Glu Lys Leu Ala His Gln Val Leu Asn Pro Glu Val Trp Pro Val Phe 
                725                 730                 735     


Asp Leu Gln Val Gly Tyr Val Asp Gly Met Pro Ala Arg Leu Trp Leu 
            740                 745                 750         


Cys Leu Asp Asn Leu Leu Leu Asp Gly Leu Ser Met Gln Ile Leu Leu 
        755                 760                 765             


Ala Glu Leu Glu His Gly Tyr Arg Tyr Pro Gln Gln Leu Leu Pro Pro 
    770                 775                 780                 


Leu Pro Val Thr Phe Arg Asp Tyr Leu Gln Gln Pro Ser Leu Gln Ser 
785                 790                 795                 800 


Pro Asn Pro Asp Ser Leu Ala Trp Trp Gln Ala Gln Leu Asp Asp Ile 
                805                 810                 815     


Pro Pro Ala Pro Ala Leu Pro Leu Arg Cys Leu Pro Gln Glu Val Glu 
            820                 825                 830         


Thr Pro Arg Phe Ala Arg Leu Asn Gly Ala Leu Asp Ser Thr Arg Trp 
        835                 840                 845             


His Arg Leu Lys Lys Arg Ala Ala Asp Ala His Leu Thr Pro Ser Ala 
    850                 855                 860                 


Val Leu Leu Ser Val Trp Ser Thr Val Leu Ser Ala Trp Ser Ala Gln 
865                 870                 875                 880 


Pro Glu Phe Thr Leu Asn Leu Thr Leu Phe Asp Arg Arg Pro Leu His 
                885                 890                 895     


Pro Gln Ile Asn Gln Ile Leu Gly Asp Phe Thr Ser Leu Met Leu Leu 
            900                 905                 910         


Ser Trp His Pro Gly Glu Ser Trp Leu His Ser Ala Gln Ser Leu Gln 
        915                 920                 925             


Gln Arg Leu Ser Gln Asn Leu Asn His Arg Asp Val Ser Ala Ile Arg 
    930                 935                 940                 


Val Met Arg Gln Leu Ala Gln Gln Gln Asn Val Pro Ala Val Pro Met 
945                 950                 955                 960 


Pro Val Val Phe Thr Ser Ala Leu Gly Phe Glu Gln Asp Asn Phe Leu 
                965                 970                 975     


Ala Arg Arg Asn Leu Leu Lys Pro Val Trp Gly Ile Ser Gln Thr Pro 
            980                 985                 990         


Gln Val Trp Leu Asp His Gln Ile  Tyr Glu Ser Glu Gly  Glu Leu Arg 
        995                 1000                 1005             


Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe Pro Ala  Gly Gln Val 
    1010                 1015                 1020             


Glu Arg  Gln Phe Glu Gln Tyr  Cys Ala Leu Leu Asn  Arg Met Ala 
    1025                 1030                 1035             


Glu Asp  Glu Ser Gly Trp Gln  Leu Pro Leu Ala Ala  Leu Val Pro 
    1040                 1045                 1050             


Pro Val  Lys His Ala Gly Gln  Cys Ala Glu Arg Ser  Pro Arg Val 
    1055                 1060                 1065             


Cys Pro  Glu Gln Ser Gln Pro  His Ile Ala Ala Asp  Glu Ser Thr 
    1070                 1075                 1080             


Val Ser  Leu Ile Cys Asp Ala  Phe Arg Glu Val Val  Gly Glu Ser 
    1085                 1090                 1095             


Val Thr  Pro Ala Glu Asn Phe  Phe Glu Ala Gly Ala  Thr Ser Leu 
    1100                 1105                 1110             


Asn Leu  Val Gln Leu His Val  Leu Leu Gln Arg His  Glu Phe Ser 
    1115                 1120                 1125             


Thr Leu  Thr Leu Leu Asp Leu  Phe Thr His Pro Ser  Pro Ala Ala 
    1130                 1135                 1140             


Leu Ala  Asp Tyr Leu Ala Gly  Val Ala Thr Val Glu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Pro  Arg Pro Val Arg Arg  Arg Gln Arg Arg Ile  Gln His Leu 
    1160                 1165                 1170             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    1175                 1180                 1185             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    1190                 1195                 1200             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    1205                 1210                 1215             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    1220                 1225                 1230             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    1235                 1240                 1245             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    1250                 1255                 1260             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    1265                 1270                 1275             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    1280                 1285                 1290             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    1295                 1300                 1305             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    1310                 1315                 1320             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    1325                 1330                 1335             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    1340                 1345                 1350             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    1355                 1360                 1365             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    1370                 1375                 1380             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    1385                 1390                 1395             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    1400                 1405                 1410             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    1415                 1420                 1425             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    1430                 1435                 1440             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    1445                 1450                 1455             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    1460                 1465                 1470             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    1475                 1480                 1485             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    1490                 1495                 1500             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    1505                 1510                 1515             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    1520                 1525                 1530             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    1535                 1540                 1545             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    1550                 1555                 1560             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    1565                 1570                 1575             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    1580                 1585                 1590             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    1595                 1600                 1605             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    1610                 1615                 1620             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    1625                 1630                 1635             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    1640                 1645                 1650             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    1655                 1660                 1665             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    1670                 1675                 1680             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    1685                 1690                 1695             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    1700                 1705                 1710             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    1715                 1720                 1725             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    1730                 1735                 1740             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    1745                 1750                 1755             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    1760                 1765                 1770             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    1775                 1780                 1785             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    1790                 1795                 1800             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    1805                 1810                 1815             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    1820                 1825                 1830             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    1835                 1840                 1845             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    1850                 1855                 1860             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    1865                 1870                 1875             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    1880                 1885                 1890             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    1895                 1900                 1905             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    1910                 1915                 1920             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    1925                 1930                 1935             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    1940                 1945                 1950             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    1955                 1960                 1965             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    1970                 1975                 1980             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    1985                 1990                 1995             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    2000                 2005                 2010             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    2015                 2020                 2025             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    2030                 2035                 2040             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    2045                 2050                 2055             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    2060                 2065                 2070             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    2075                 2080                 2085             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    2090                 2095                 2100             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    2105                 2110                 2115             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    2120                 2125                 2130             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    2135                 2140                 2145             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    2150                 2155                 2160             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    2165                 2170                 2175             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    2180                 2185                 2190             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    2195                 2200                 2205             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    2210                 2215                 2220             


Ile Leu  Pro Val Glu Gln Pro  Phe Val His Ser Pro  Glu Glu Arg 
    2225                 2230                 2235             


Tyr Arg  Pro Phe Ala Leu Thr  Asp Val Gln Gln Ala  Tyr Leu Val 
    2240                 2245                 2250             


Gly Arg  Gln Pro Gly Phe Ala  Leu Gly Gly Val Gly  Ser His Phe 
    2255                 2260                 2265             


Phe Val  Glu Phe Glu Ile Ala  Asp Leu Asp Ile His  Arg Leu Glu 
    2270                 2275                 2280             


Lys Val  Trp Asn Arg Leu Ile  Ala Arg His Asp Met  Leu Arg Ala 
    2285                 2290                 2295             


Val Val  Arg Asp Gly Gln Gln  Arg Val Leu Glu Gln  Thr Pro Pro 
    2300                 2305                 2310             


Trp Val  Ile Pro Ala His Ile  Leu His Ser Pro Glu  Glu Ala Leu 
    2315                 2320                 2325             


Gln Val  Arg Asp Arg Leu Ala  His Gln Val Leu Asn  Pro Glu Val 
    2330                 2335                 2340             


Trp Pro  Val Phe Asp Leu Gln  Val Gly Phe Val Asp  Gly Met Pro 
    2345                 2350                 2355             


Ala Arg  Leu Trp Leu Cys Leu  Asp Asn Leu Leu Leu  Asp Gly Leu 
    2360                 2365                 2370             


Ser Met  Gln Ile Leu Leu Ser  Glu Leu Glu His Gly  Tyr Arg Tyr 
    2375                 2380                 2385             


Pro Gln  Gln Leu Pro Pro Pro  Leu Pro Ile Thr Phe  Arg Asp Tyr 
    2390                 2395                 2400             


Leu Gln  Gln Pro Ala Leu Arg  Thr Pro Asn Pro Asp  Ser Leu Ala 
    2405                 2410                 2415             


Trp Trp  Gln Thr Gln Leu Asp  Asp Ile Pro Pro Ala  Pro Ala Leu 
    2420                 2425                 2430             


Pro Leu  Arg Cys Leu Pro Gln  Asp Val Glu Thr Pro  Arg Phe Ala 
    2435                 2440                 2445             


Arg Leu  Tyr Gly Ala Met Asp  Ser Ala Arg Trp Arg  Arg Leu Lys 
    2450                 2455                 2460             


Gln Arg  Ala Ala Asp Ala His  Leu Thr Pro Ser Ala  Val Leu Leu 
    2465                 2470                 2475             


Ser Val  Trp Ser Thr Val Leu  Ala Ala Trp Ser Ala  Gln Pro Asp 
    2480                 2485                 2490             


Phe Thr  Leu Asn Leu Thr Leu  Phe Asp Arg Arg Pro  Leu His Pro 
    2495                 2500                 2505             


Gln Ile  Asn Gln Ile Leu Gly  Asp Phe Thr Ser Leu  Met Leu Leu 
    2510                 2515                 2520             


Ser Trp  His Pro Gly Glu Ser  Trp Leu Gln Ser Ala  Arg Leu Leu 
    2525                 2530                 2535             


Gln Gln  Arg Leu Ser Glu Ser  Leu Asn His Arg Asp  Val Ser Ala 
    2540                 2545                 2550             


Ile Arg  Val Met Arg Gln Leu  Ala Arg Arg Gln Asn  Val Pro Ala 
    2555                 2560                 2565             


Val Pro  Met Pro Val Val Phe  Thr Ser Ala Leu Gly  Phe Glu Gln 
    2570                 2575                 2580             


Asp Asn  Phe Leu Ala Arg Arg  Asn Leu Leu Lys Pro  Val Trp Gly 
    2585                 2590                 2595             


Ile Ser  Gln Thr Pro Gln Val  Trp Leu Asp His Gln  Val Tyr Glu 
    2600                 2605                 2610             


Ser Glu  Gly Glu Leu Arg Phe  Asn Trp Asp Phe Val  Ala Ala Leu 
    2615                 2620                 2625             


Phe Pro  Asp Gly Gln Val Glu  Arg Gln Phe Ala Gln  Tyr Cys Ala 
    2630                 2635                 2640             


Leu Leu  Asn Arg Met Ala Glu  Asp Asp Ser Ser Trp  Gln Leu Pro 
    2645                 2650                 2655             


Leu Ala  Asp Leu Val Pro Pro  Leu Lys Val Thr Glu  Arg Arg Ala 
    2660                 2665                 2670             


Arg Arg  Leu Arg Pro Glu Arg  Ala Gln Pro Arg Ile  Ala Ala Asp 
    2675                 2680                 2685             


Lys Ser  Ser Val Ser Leu Ile  Cys Asp Thr Phe Arg  Glu Val Val 
    2690                 2695                 2700             


Gly Glu  Pro Val Ala Pro Ala  Glu Asn Phe Phe Glu  Ala Gly Ala 
    2705                 2710                 2715             


Thr Ser  Leu Asn Leu Val Gln  Leu His Val Leu Leu  Gln Arg His 
    2720                 2725                 2730             


Glu Phe  Ala Thr Leu Thr Leu  Leu Asp Leu Phe Thr  His Pro Ser 
    2735                 2740                 2745             


Pro Val  Ala Leu Ala Asn Tyr  Leu Ala Gly Val Ala  Leu Glu Glu 
    2750                 2755                 2760             


Lys Thr  Lys Arg Val Arg Pro  Val Arg Arg Arg Gln  Arg Arg Ile 
    2765                 2770                 2775             


Gln His  Leu Pro Leu Val Ala  Ala Gln Pro Gly Ile  Trp Met Ala 
    2780                 2785                 2790             


Glu Lys  Leu Ser Glu Leu Pro  Ser Ala Trp Ser Val  Ala His Tyr 
    2795                 2800                 2805             


Val Glu  Leu Thr Gly Glu Val  Asp Ser Pro Leu Leu  Ala Arg Ala 
    2810                 2815                 2820             


Val Val  Ala Gly Leu Ala Gln  Ala Asp Thr Leu Arg  Met Arg Phe 
    2825                 2830                 2835             


Thr Glu  Asp Asn Gly Glu Val  Trp Gln Trp Val Asp  Asp Ala Leu 
    2840                 2845                 2850             


Thr Phe  Glu Leu Pro Glu Ile  Ile Asp Leu Arg Thr  Asn Ile Asp 
    2855                 2860                 2865             


Pro His  Gly Thr Ala Gln Ala  Leu Met Gln Ala Asp  Leu Gln Gln 
    2870                 2875                 2880             


Asp Leu  Arg Val Asp Ser Gly  Lys Pro Leu Val Phe  His Gln Leu 
    2885                 2890                 2895             


Ile Gln  Val Ala Asp Asn Arg  Trp Tyr Trp Tyr Gln  Arg Tyr His 
    2900                 2905                 2910             


His Leu  Leu Val Asp Gly Phe  Ser Phe Pro Ala Ile  Thr Arg Gln 
    2915                 2920                 2925             


Ile Ala  Asn Ile Tyr Cys Thr  Trp Leu Arg Gly Glu  Pro Thr Pro 
    2930                 2935                 2940             


Ala Ser  Pro Phe Thr Pro Phe  Ala Asp Val Val Glu  Glu Tyr Gln 
    2945                 2950                 2955             


Gln Tyr  Arg Glu Ser Glu Ala  Trp Gln Arg Asp Ala  Ala Phe Trp 
    2960                 2965                 2970             


Ala Glu  Gln Arg Arg Gln Leu  Pro Pro Pro Ala Ser  Leu Ser Pro 
    2975                 2980                 2985             


Ala Pro  Leu Pro Gly Arg Ser  Ala Ser Ala Asp Ile  Leu Arg Leu 
    2990                 2995                 3000             


Lys Leu  Glu Phe Thr Asp Gly  Glu Phe Arg Gln Leu  Ala Thr Gln 
    3005                 3010                 3015             


Leu Ser  Gly Val Gln Arg Thr  Asp Leu Ala Leu Ala  Leu Ala Ala 
    3020                 3025                 3030             


Leu Trp  Leu Gly Arg Leu Cys  Asn Arg Met Asp Tyr  Ala Ala Gly 
    3035                 3040                 3045             


Phe Ile  Phe Met Arg Arg Leu  Gly Ser Ala Ala Leu  Thr Ala Thr 
    3050                 3055                 3060             


Gly Pro  Val Leu Asn Val Leu  Pro Leu Gly Ile His  Ile Gly Asn 
    3065                 3070                 3075             


Pro Ser  Phe Ser Glu Leu Leu  Thr Arg Val Arg Glu  Val Ala Leu 
    3080                 3085                 3090             


Gly Ala  Tyr Ala His Gln His  Ile Pro Phe Glu Met  Leu Val Glu 
    3095                 3100                 3105             


Ala Leu  Gln Pro Glu Arg Asn  Leu Ser His Thr Pro  Leu Phe Gln 
    3110                 3115                 3120             


Val Met  Phe Val Leu Gln Asn  Ala Pro Ala Ser Gln  Leu Glu Leu 
    3125                 3130                 3135             


Thr Gly  Ile Thr Ala Asn Pro  Ile Lys Val Lys Ser  Thr Thr Thr 
    3140                 3145                 3150             


Lys Phe  Asp Leu Thr Leu Ile  Met Gln Asn Thr Ala  Ser Gly Leu 
    3155                 3160                 3165             


Val Gly  Val Trp Glu Tyr Asn  Thr Asp Leu Phe Asp  Ala Ser Thr 
    3170                 3175                 3180             


Ile Glu  Arg Met Thr Gly His  Phe Val Thr Leu Leu  Glu Gly Val 
    3185                 3190                 3195             


Ile Ala  Asn Pro Gln Gln Pro  Ile Ser Gln Leu Pro  Ile Leu Thr 
    3200                 3205                 3210             


Thr Val  Glu Gln Gln Gln Leu  Leu Val Glu Trp Asn  Asn Thr Gln 
    3215                 3220                 3225             


Thr Asp  Tyr Pro Ala Asp Lys  Cys Ile His Gln Leu  Phe Glu Glu 
    3230                 3235                 3240             


Gln Val  Glu Arg Thr Pro Asp  Ala Val Ala Val Val  Phe Gly Asn 
    3245                 3250                 3255             


Gln Gln  Leu Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    3260                 3265                 3270             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    3275                 3280                 3285             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    3290                 3295                 3300             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    3305                 3310                 3315             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    3320                 3325                 3330             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    3335                 3340                 3345             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    3350                 3355                 3360             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    3365                 3370                 3375             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    3380                 3385                 3390             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    3395                 3400                 3405             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    3410                 3415                 3420             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    3425                 3430                 3435             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    3440                 3445                 3450             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    3455                 3460                 3465             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    3470                 3475                 3480             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    3485                 3490                 3495             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    3500                 3505                 3510             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    3515                 3520                 3525             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    3530                 3535                 3540             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    3545                 3550                 3555             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    3560                 3565                 3570             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    3575                 3580                 3585             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    3590                 3595                 3600             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    3605                 3610                 3615             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    3620                 3625                 3630             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    3635                 3640                 3645             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    3650                 3655                 3660             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    3665                 3670                 3675             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    3680                 3685                 3690             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    3695                 3700                 3705             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    3710                 3715                 3720             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    3725                 3730                 3735             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Glu 
    3740                 3745                 3750             


Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val 
    3755                 3760                 3765             


Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu 
    3770                 3775                 3780             


Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg 
    3785                 3790                 3795             


Gln Val  Thr Pro Gly Gln Val  Met Val Ala Ser Thr  Val Ala Lys 
    3800                 3805                 3810             


Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Asp Lys Tyr  Val Ala Pro 
    3815                 3820                 3825             


Arg Asn  Pro Ile Thr Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys 
    3830                 3835                 3840             


Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly 
    3845                 3850                 3855             


Pro Pro  Val Glu His Arg Ala  Arg Leu Val Cys Phe  Pro His Ala 
    3860                 3865                 3870             


Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala 
    3875                 3880                 3885             


Pro Glu  Ile Asp Val His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp 
    3890                 3895                 3900             


Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp 
    3905                 3910                 3915             


Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe 
    3920                 3925                 3930             


Ala Leu  Phe Gly His Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr 
    3935                 3940                 3945             


Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu 
    3950                 3955                 3960             


Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val His Glu  Arg Arg Thr 
    3965                 3970                 3975             


Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu 
    3980                 3985                 3990             


Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met 
    3995                 4000                 4005             


Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr 
    4010                 4015                 4020             


Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu 
    4025                 4030                 4035             


Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg 
    4040                 4045                 4050             


Trp Leu  Gln His Ser Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro 
    4055                 4060                 4065             


Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly 
    4070                 4075                 4080             


Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly Leu Ala  Gly 
    4085                 4090                 4095     


<210>  49
<211>  3986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCC

<400>  49

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    1055                 1060                 1065             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    1070                 1075                 1080             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    1085                 1090                 1095             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    1100                 1105                 1110             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    1115                 1120                 1125             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    1130                 1135                 1140             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    1145                 1150                 1155             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    1160                 1165                 1170             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    1175                 1180                 1185             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    1190                 1195                 1200             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    1205                 1210                 1215             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    1220                 1225                 1230             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    1235                 1240                 1245             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    1250                 1255                 1260             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    1265                 1270                 1275             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    1280                 1285                 1290             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    1295                 1300                 1305             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    1310                 1315                 1320             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    1325                 1330                 1335             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    1340                 1345                 1350             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    1355                 1360                 1365             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    1370                 1375                 1380             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    1385                 1390                 1395             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    1400                 1405                 1410             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    1415                 1420                 1425             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    1430                 1435                 1440             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    1445                 1450                 1455             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    1460                 1465                 1470             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    1475                 1480                 1485             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    1490                 1495                 1500             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    1505                 1510                 1515             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    1520                 1525                 1530             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    1535                 1540                 1545             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    1550                 1555                 1560             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    1565                 1570                 1575             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    1580                 1585                 1590             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    1595                 1600                 1605             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    1610                 1615                 1620             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    1625                 1630                 1635             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    1640                 1645                 1650             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    1655                 1660                 1665             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    1670                 1675                 1680             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    1685                 1690                 1695             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    1700                 1705                 1710             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    1715                 1720                 1725             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    1730                 1735                 1740             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    1745                 1750                 1755             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    1760                 1765                 1770             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    1775                 1780                 1785             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    1790                 1795                 1800             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    1805                 1810                 1815             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    1820                 1825                 1830             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    1835                 1840                 1845             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    1850                 1855                 1860             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    1865                 1870                 1875             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    1880                 1885                 1890             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    1895                 1900                 1905             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    1910                 1915                 1920             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    1925                 1930                 1935             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    1940                 1945                 1950             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    1955                 1960                 1965             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    1970                 1975                 1980             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    1985                 1990                 1995             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    2000                 2005                 2010             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    2015                 2020                 2025             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    2030                 2035                 2040             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    2045                 2050                 2055             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    2060                 2065                 2070             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    2075                 2080                 2085             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    2090                 2095                 2100             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu 
    2105                 2110                 2115             


Pro Val  Glu Gln Pro Phe Val  His Ser Pro Glu Glu  Arg Tyr Arg 
    2120                 2125                 2130             


Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala Tyr Leu  Val Gly Arg 
    2135                 2140                 2145             


Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly Ser His  Phe Phe Val 
    2150                 2155                 2160             


Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His Arg Leu  Glu Lys Val 
    2165                 2170                 2175             


Trp Asn  Arg Leu Ile Ala Arg  His Asp Met Leu Arg  Ala Val Val 
    2180                 2185                 2190             


Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln Thr Pro  Pro Trp Val 
    2195                 2200                 2205             


Ile Pro  Ala His Ile Leu His  Ser Pro Glu Glu Ala  Leu Gln Val 
    2210                 2215                 2220             


Arg Asp  Arg Leu Ala His Gln  Val Leu Asn Pro Glu  Val Trp Pro 
    2225                 2230                 2235             


Val Phe  Asp Leu Gln Val Gly  Phe Val Asp Gly Met  Pro Ala Arg 
    2240                 2245                 2250             


Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu Asp Gly  Leu Ser Met 
    2255                 2260                 2265             


Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly Tyr Arg  Tyr Pro Gln 
    2270                 2275                 2280             


Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe Arg Asp  Tyr Leu Gln 
    2285                 2290                 2295             


Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp Ser Leu  Ala Trp Trp 
    2300                 2305                 2310             


Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala Pro Ala  Leu Pro Leu 
    2315                 2320                 2325             


Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro Arg Phe  Ala Arg Leu 
    2330                 2335                 2340             


Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg Arg Leu  Lys Gln Arg 
    2345                 2350                 2355             


Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala Val Leu  Leu Ser Val 
    2360                 2365                 2370             


Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala Gln Pro  Asp Phe Thr 
    2375                 2380                 2385             


Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro Leu His  Pro Gln Ile 
    2390                 2395                 2400             


Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu Met Leu  Leu Ser Trp 
    2405                 2410                 2415             


His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala Arg Leu  Leu Gln Gln 
    2420                 2425                 2430             


Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp Val Ser  Ala Ile Arg 
    2435                 2440                 2445             


Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn Val Pro  Ala Val Pro 
    2450                 2455                 2460             


Met Pro  Val Val Phe Thr Ser  Ala Leu Gly Phe Glu  Gln Asp Asn 
    2465                 2470                 2475             


Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro Val Trp  Gly Ile Ser 
    2480                 2485                 2490             


Gln Thr  Pro Gln Val Trp Leu  Asp His Gln Val Tyr  Glu Ser Glu 
    2495                 2500                 2505             


Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val Ala Ala  Leu Phe Pro 
    2510                 2515                 2520             


Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln Tyr Cys  Ala Leu Leu 
    2525                 2530                 2535             


Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp Gln Leu  Pro Leu Ala 
    2540                 2545                 2550             


Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu Arg Arg  Ala Arg Arg 
    2555                 2560                 2565             


Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile Ala Ala  Asp Lys Ser 
    2570                 2575                 2580             


Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg Glu Val  Val Gly Glu 
    2585                 2590                 2595             


Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
    2600                 2605                 2610             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    2615                 2620                 2625             


Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Val 
    2630                 2635                 2640             


Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala Leu Glu  Glu Lys Thr 
    2645                 2650                 2655             


Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    2660                 2665                 2670             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    2675                 2680                 2685             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    2690                 2695                 2700             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    2705                 2710                 2715             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    2720                 2725                 2730             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    2735                 2740                 2745             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    2750                 2755                 2760             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    2765                 2770                 2775             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    2780                 2785                 2790             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    2795                 2800                 2805             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    2810                 2815                 2820             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    2825                 2830                 2835             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    2840                 2845                 2850             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    2855                 2860                 2865             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    2870                 2875                 2880             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    2885                 2890                 2895             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    2900                 2905                 2910             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    2915                 2920                 2925             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    2930                 2935                 2940             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    2945                 2950                 2955             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    2960                 2965                 2970             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    2975                 2980                 2985             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    2990                 2995                 3000             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    3005                 3010                 3015             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    3020                 3025                 3030             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    3035                 3040                 3045             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    3050                 3055                 3060             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    3065                 3070                 3075             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    3080                 3085                 3090             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    3095                 3100                 3105             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    3110                 3115                 3120             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    3125                 3130                 3135             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    3140                 3145                 3150             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    3155                 3160                 3165             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    3170                 3175                 3180             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    3185                 3190                 3195             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    3200                 3205                 3210             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    3215                 3220                 3225             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    3230                 3235                 3240             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    3245                 3250                 3255             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    3260                 3265                 3270             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    3275                 3280                 3285             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    3290                 3295                 3300             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    3305                 3310                 3315             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    3320                 3325                 3330             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    3335                 3340                 3345             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    3350                 3355                 3360             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    3365                 3370                 3375             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    3380                 3385                 3390             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    3395                 3400                 3405             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    3410                 3415                 3420             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    3425                 3430                 3435             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    3440                 3445                 3450             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    3455                 3460                 3465             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    3470                 3475                 3480             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    3485                 3490                 3495             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    3500                 3505                 3510             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    3515                 3520                 3525             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    3530                 3535                 3540             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    3545                 3550                 3555             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    3560                 3565                 3570             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    3575                 3580                 3585             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    3590                 3595                 3600             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    3605                 3610                 3615             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    3620                 3625                 3630             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    3635                 3640                 3645             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    3650                 3655                 3660             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    3665                 3670                 3675             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    3680                 3685                 3690             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    3695                 3700                 3705             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Thr 
    3710                 3715                 3720             


Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu 
    3725                 3730                 3735             


Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly Pro Pro  Val Glu His 
    3740                 3745                 3750             


Arg Ala  Arg Leu Val Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp 
    3755                 3760                 3765             


Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val 
    3770                 3775                 3780             


His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu 
    3785                 3790                 3795             


Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val 
    3800                 3805                 3810             


Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His 
    3815                 3820                 3825             


Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu 
    3830                 3835                 3840             


Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln 
    3845                 3850                 3855             


Thr Ala  Pro Arg Val His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp 
    3860                 3865                 3870             


Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala 
    3875                 3880                 3885             


Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu 
    3890                 3895                 3900             


Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly 
    3905                 3910                 3915             


Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp 
    3920                 3925                 3930             


Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser 
    3935                 3940                 3945             


Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr 
    3950                 3955                 3960             


Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp 
    3965                 3970                 3975             


Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3980                 3985     


<210>  50
<211>  4427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCH

<400>  50

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    1055                 1060                 1065             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    1070                 1075                 1080             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    1085                 1090                 1095             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    1100                 1105                 1110             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    1115                 1120                 1125             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    1130                 1135                 1140             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    1145                 1150                 1155             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    1160                 1165                 1170             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    1175                 1180                 1185             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    1190                 1195                 1200             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    1205                 1210                 1215             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    1220                 1225                 1230             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    1235                 1240                 1245             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    1250                 1255                 1260             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    1265                 1270                 1275             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    1280                 1285                 1290             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    1295                 1300                 1305             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    1310                 1315                 1320             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    1325                 1330                 1335             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    1340                 1345                 1350             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    1355                 1360                 1365             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    1370                 1375                 1380             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    1385                 1390                 1395             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    1400                 1405                 1410             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    1415                 1420                 1425             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    1430                 1435                 1440             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    1445                 1450                 1455             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    1460                 1465                 1470             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    1475                 1480                 1485             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    1490                 1495                 1500             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    1505                 1510                 1515             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    1520                 1525                 1530             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    1535                 1540                 1545             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    1550                 1555                 1560             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    1565                 1570                 1575             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    1580                 1585                 1590             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    1595                 1600                 1605             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    1610                 1615                 1620             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    1625                 1630                 1635             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    1640                 1645                 1650             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    1655                 1660                 1665             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    1670                 1675                 1680             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    1685                 1690                 1695             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    1700                 1705                 1710             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    1715                 1720                 1725             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    1730                 1735                 1740             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    1745                 1750                 1755             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    1760                 1765                 1770             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    1775                 1780                 1785             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    1790                 1795                 1800             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    1805                 1810                 1815             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    1820                 1825                 1830             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    1835                 1840                 1845             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    1850                 1855                 1860             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    1865                 1870                 1875             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    1880                 1885                 1890             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    1895                 1900                 1905             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    1910                 1915                 1920             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    1925                 1930                 1935             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    1940                 1945                 1950             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    1955                 1960                 1965             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    1970                 1975                 1980             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    1985                 1990                 1995             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    2000                 2005                 2010             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    2015                 2020                 2025             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    2030                 2035                 2040             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    2045                 2050                 2055             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    2060                 2065                 2070             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    2075                 2080                 2085             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    2090                 2095                 2100             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Pro 
    2105                 2110                 2115             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2120                 2125                 2130             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2135                 2140                 2145             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2150                 2155                 2160             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2165                 2170                 2175             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2180                 2185                 2190             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2195                 2200                 2205             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2210                 2215                 2220             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2225                 2230                 2235             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2240                 2245                 2250             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2255                 2260                 2265             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2270                 2275                 2280             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2285                 2290                 2295             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2300                 2305                 2310             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2315                 2320                 2325             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2330                 2335                 2340             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2345                 2350                 2355             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2360                 2365                 2370             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2375                 2380                 2385             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2390                 2395                 2400             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2405                 2410                 2415             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2420                 2425                 2430             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2435                 2440                 2445             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2450                 2455                 2460             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    2465                 2470                 2475             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    2480                 2485                 2490             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    2495                 2500                 2505             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    2510                 2515                 2520             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    2525                 2530                 2535             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    2540                 2545                 2550             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    2555                 2560                 2565             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    2570                 2575                 2580             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    2585                 2590                 2595             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    2600                 2605                 2610             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    2615                 2620                 2625             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    2630                 2635                 2640             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    2645                 2650                 2655             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    2660                 2665                 2670             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    2675                 2680                 2685             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    2690                 2695                 2700             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    2705                 2710                 2715             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    2720                 2725                 2730             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    2735                 2740                 2745             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    2750                 2755                 2760             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    2765                 2770                 2775             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    2780                 2785                 2790             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    2795                 2800                 2805             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    2810                 2815                 2820             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    2825                 2830                 2835             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    2840                 2845                 2850             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    2855                 2860                 2865             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    2870                 2875                 2880             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    2885                 2890                 2895             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    2900                 2905                 2910             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    2915                 2920                 2925             


Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg 
    2930                 2935                 2940             


Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala Ala Val  Asp Phe Ser 
    2945                 2950                 2955             


Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala 
    2960                 2965                 2970             


Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn 
    2975                 2980                 2985             


Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val His Pro  Leu Leu Leu 
    2990                 2995                 3000             


Ala Ala  Val Asp Val Pro Gly  His Gly Gly Ala Val  Phe Thr Gly 
    3005                 3010                 3015             


Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu Ala Glu  His Val Val 
    3020                 3025                 3030             


Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val Leu Val  Asp Leu Ala 
    3035                 3040                 3045             


Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu 
    3050                 3055                 3060             


Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu 
    3065                 3070                 3075             


Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile 
    3080                 3085                 3090             


Asp Val  His Ala Ala Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln 
    3095                 3100                 3105             


Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala 
    3110                 3115                 3120             


Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg 
    3125                 3130                 3135             


Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr 
    3140                 3145                 3150             


Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu 
    3155                 3160                 3165             


Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser 
    3170                 3175                 3180             


Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu 
    3185                 3190                 3195             


Asp Ala  Cys Phe Gln Ser Val  Gly Ala His Pro Asp  Ser Gln Ser 
    3200                 3205                 3210             


Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly Val Arg  Arg Val Arg 
    3215                 3220                 3225             


Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val 
    3230                 3235                 3240             


Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu 
    3245                 3250                 3255             


Asp Ala  His Gly Thr Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile 
    3260                 3265                 3270             


Gly Thr  Gly Val Ser Glu Arg  Asp Lys His Asn Arg  Val Leu Asn 
    3275                 3280                 3285             


Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu 
    3290                 3295                 3300             


Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys 
    3305                 3310                 3315             


Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg 
    3320                 3325                 3330             


Glu His  Ser Ala Ala Cys Thr  Thr Met Arg Trp Pro  Leu His Asp 
    3335                 3340                 3345             


Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser 
    3350                 3355                 3360             


Asp Glu  Phe Ser Gly Val Val  Val Leu Thr Gly Pro  Asn Thr Gly 
    3365                 3370                 3375             


Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg 
    3380                 3385                 3390             


Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala 
    3395                 3400                 3405             


Val Pro  Arg Met Tyr Val Val  Thr Arg Gly Ala Gln  Arg Val Leu 
    3410                 3415                 3420             


Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu 
    3425                 3430                 3435             


Leu Arg  Thr Ile Gly Ala Glu  His Pro His Leu Arg  Ala Thr Gln 
    3440                 3445                 3450             


Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln 
    3455                 3460                 3465             


Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn 
    3470                 3475                 3480             


Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln 
    3485                 3490                 3495             


Glu Arg  Arg Thr Ile Val Ala  Asp His Gln Gln Ser  Gly Met Arg 
    3500                 3505                 3510             


Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu 
    3515                 3520                 3525             


Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg 
    3530                 3535                 3540             


Val Asp  Val Arg Ala Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu 
    3545                 3550                 3555             


Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala 
    3560                 3565                 3570             


Ala Gly  Val Val Thr Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala 
    3575                 3580                 3585             


Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro 
    3590                 3595                 3600             


Ile Ala  Val Thr Asp His Arg  Leu Leu Ala Arg Val  Pro Asp Gly 
    3605                 3610                 3615             


Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr 
    3620                 3625                 3630             


Ala His  Tyr Ala Leu His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln 
    3635                 3640                 3645             


Ser Val  Leu Ile His Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala 
    3650                 3655                 3660             


Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala 
    3665                 3670                 3675             


Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp 
    3680                 3685                 3690             


Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe 
    3695                 3700                 3705             


Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp Val Val  Leu Asn Ser 
    3710                 3715                 3720             


Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu 
    3725                 3730                 3735             


Asp Gly  Val Phe Val Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala 
    3740                 3745                 3750             


Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala 
    3755                 3760                 3765             


Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu 
    3770                 3775                 3780             


Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu 
    3785                 3790                 3795             


Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro 
    3800                 3805                 3810             


Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr 
    3815                 3820                 3825             


Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu Ala Arg  His Leu Val 
    3830                 3835                 3840             


Thr Glu  His Gly Val Arg His  Leu Leu Leu Val Ser  Arg Arg Gly 
    3845                 3850                 3855             


Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp 
    3860                 3865                 3870             


Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg 
    3875                 3880                 3885             


Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr 
    3890                 3895                 3900             


Gly Val  Val His Ala Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr 
    3905                 3910                 3915             


Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val Leu Arg  Ala Lys Val 
    3920                 3925                 3930             


Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu 
    3935                 3940                 3945             


Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly 
    3950                 3955                 3960             


Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala 
    3965                 3970                 3975             


Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu 
    3980                 3985                 3990             


Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu 
    3995                 4000                 4005             


Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe 
    4010                 4015                 4020             


Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro 
    4025                 4030                 4035             


Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro 
    4040                 4045                 4050             


Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr 
    4055                 4060                 4065             


Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp 
    4070                 4075                 4080             


Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu Val Arg  Ser His Ala 
    4085                 4090                 4095             


Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg 
    4100                 4105                 4110             


Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu 
    4115                 4120                 4125             


Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser 
    4130                 4135                 4140             


Thr Leu  Val Phe Asp His Pro  Thr Pro Leu Ala Val  Ala Glu His 
    4145                 4150                 4155             


Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    4160                 4165                 4170             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    4175                 4180                 4185             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    4190                 4195                 4200             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    4205                 4210                 4215             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    4220                 4225                 4230             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    4235                 4240                 4245             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    4250                 4255                 4260             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    4265                 4270                 4275             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    4280                 4285                 4290             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    4295                 4300                 4305             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    4310                 4315                 4320             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    4325                 4330                 4335             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    4340                 4345                 4350             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    4355                 4360                 4365             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    4370                 4375                 4380             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    4385                 4390                 4395             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    4400                 4405                 4410             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    4415                 4420                 4425         


<210>  51
<211>  3876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCO

<400>  51

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    1055                 1060                 1065             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    1070                 1075                 1080             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    1085                 1090                 1095             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    1100                 1105                 1110             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    1115                 1120                 1125             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    1130                 1135                 1140             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    1145                 1150                 1155             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    1160                 1165                 1170             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    1175                 1180                 1185             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    1190                 1195                 1200             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    1205                 1210                 1215             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    1220                 1225                 1230             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    1235                 1240                 1245             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    1250                 1255                 1260             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    1265                 1270                 1275             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    1280                 1285                 1290             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    1295                 1300                 1305             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    1310                 1315                 1320             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    1325                 1330                 1335             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    1340                 1345                 1350             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    1355                 1360                 1365             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    1370                 1375                 1380             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    1385                 1390                 1395             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    1400                 1405                 1410             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    1415                 1420                 1425             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    1430                 1435                 1440             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    1445                 1450                 1455             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    1460                 1465                 1470             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    1475                 1480                 1485             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    1490                 1495                 1500             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    1505                 1510                 1515             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    1520                 1525                 1530             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    1535                 1540                 1545             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    1550                 1555                 1560             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    1565                 1570                 1575             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    1580                 1585                 1590             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    1595                 1600                 1605             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    1610                 1615                 1620             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    1625                 1630                 1635             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    1640                 1645                 1650             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    1655                 1660                 1665             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    1670                 1675                 1680             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    1685                 1690                 1695             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    1700                 1705                 1710             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    1715                 1720                 1725             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    1730                 1735                 1740             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    1745                 1750                 1755             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    1760                 1765                 1770             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    1775                 1780                 1785             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    1790                 1795                 1800             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    1805                 1810                 1815             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    1820                 1825                 1830             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    1835                 1840                 1845             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    1850                 1855                 1860             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    1865                 1870                 1875             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    1880                 1885                 1890             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    1895                 1900                 1905             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    1910                 1915                 1920             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    1925                 1930                 1935             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    1940                 1945                 1950             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    1955                 1960                 1965             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    1970                 1975                 1980             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    1985                 1990                 1995             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    2000                 2005                 2010             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    2015                 2020                 2025             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    2030                 2035                 2040             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    2045                 2050                 2055             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    2060                 2065                 2070             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    2075                 2080                 2085             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    2090                 2095                 2100             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Pro 
    2105                 2110                 2115             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2120                 2125                 2130             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2135                 2140                 2145             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2150                 2155                 2160             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2165                 2170                 2175             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2180                 2185                 2190             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2195                 2200                 2205             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2210                 2215                 2220             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2225                 2230                 2235             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2240                 2245                 2250             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2255                 2260                 2265             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2270                 2275                 2280             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2285                 2290                 2295             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2300                 2305                 2310             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2315                 2320                 2325             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2330                 2335                 2340             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2345                 2350                 2355             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2360                 2365                 2370             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2375                 2380                 2385             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2390                 2395                 2400             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2405                 2410                 2415             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2420                 2425                 2430             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2435                 2440                 2445             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2450                 2455                 2460             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    2465                 2470                 2475             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    2480                 2485                 2490             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    2495                 2500                 2505             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    2510                 2515                 2520             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    2525                 2530                 2535             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    2540                 2545                 2550             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    2555                 2560                 2565             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    2570                 2575                 2580             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    2585                 2590                 2595             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    2600                 2605                 2610             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    2615                 2620                 2625             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    2630                 2635                 2640             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    2645                 2650                 2655             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    2660                 2665                 2670             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    2675                 2680                 2685             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    2690                 2695                 2700             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    2705                 2710                 2715             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    2720                 2725                 2730             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    2735                 2740                 2745             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    2750                 2755                 2760             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    2765                 2770                 2775             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    2780                 2785                 2790             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    2795                 2800                 2805             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    2810                 2815                 2820             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    2825                 2830                 2835             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    2840                 2845                 2850             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    2855                 2860                 2865             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    2870                 2875                 2880             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    2885                 2890                 2895             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    2900                 2905                 2910             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    2915                 2920                 2925             


Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr 
    2930                 2935                 2940             


Val Leu  Gly His Leu Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His 
    2945                 2950                 2955             


Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln 
    2960                 2965                 2970             


Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp 
    2975                 2980                 2985             


Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly 
    2990                 2995                 3000             


Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp 
    3005                 3010                 3015             


Gln His  Thr Leu Gln Val Leu  Thr Lys Leu Ala Ala  Gln His Asn 
    3020                 3025                 3030             


Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile 
    3035                 3040                 3045             


Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp 
    3050                 3055                 3060             


Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp Asp Ala  Asp Ala Val 
    3065                 3070                 3075             


Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln 
    3080                 3085                 3090             


Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala 
    3095                 3100                 3105             


Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile 
    3110                 3115                 3120             


Val His  Val Ala Ala Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg 
    3125                 3130                 3135             


Ser Leu  Leu Arg Met Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg 
    3140                 3145                 3150             


Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp 
    3155                 3160                 3165             


Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val 
    3170                 3175                 3180             


Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser 
    3185                 3190                 3195             


Leu Glu  Leu Pro His Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu 
    3200                 3205                 3210             


Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg 
    3215                 3220                 3225             


Ile Ala  Ala Pro His Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala 
    3230                 3235                 3240             


Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser 
    3245                 3250                 3255             


Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr 
    3260                 3265                 3270             


Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala 
    3275                 3280                 3285             


Arg His  Leu Val Thr Glu His  Gly Val Arg His Leu  Leu Leu Val 
    3290                 3295                 3300             


Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala 
    3305                 3310                 3315             


Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp 
    3320                 3325                 3330             


Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro 
    3335                 3340                 3345             


Arg Pro  Leu Thr Gly Val Val  His Ala Ala Gly Val  Leu Ala Asp 
    3350                 3355                 3360             


Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu 
    3365                 3370                 3375             


Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala 
    3380                 3385                 3390             


Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser 
    3395                 3400                 3405             


Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu 
    3410                 3415                 3420             


Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro 
    3425                 3430                 3435             


Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile 
    3440                 3445                 3450             


Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly 
    3455                 3460                 3465             


Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser 
    3470                 3475                 3480             


Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala 
    3485                 3490                 3495             


Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn 
    3500                 3505                 3510             


Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro 
    3515                 3520                 3525             


Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val 
    3530                 3535                 3540             


Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln 
    3545                 3550                 3555             


Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu 
    3560                 3565                 3570             


Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val 
    3575                 3580                 3585             


Arg Leu  Pro Ser Thr Leu Val  Phe Asp His Pro Thr  Pro Leu Ala 
    3590                 3595                 3600             


Val Ala  Glu His Leu Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn 
    3605                 3610                 3615             


Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp 
    3620                 3625                 3630             


Leu Arg  Arg Phe Gly Pro Pro  Val Glu His Arg Ala  Arg Leu Val 
    3635                 3640                 3645             


Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu 
    3650                 3655                 3660             


Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val His Ala  Val Gln Tyr 
    3665                 3670                 3675             


Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala 
    3680                 3685                 3690             


Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly 
    3695                 3700                 3705             


Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His Ser Met  Gly Ala Leu 
    3710                 3715                 3720             


Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly 
    3725                 3730                 3735             


Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val 
    3740                 3745                 3750             


His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp 
    3755                 3760                 3765             


Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu 
    3770                 3775                 3780             


Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg 
    3785                 3790                 3795             


Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala 
    3800                 3805                 3810             


Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr 
    3815                 3820                 3825             


Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser Val Ile  Pro Gly Arg 
    3830                 3835                 3840             


Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val 
    3845                 3850                 3855             


Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly 
    3860                 3865                 3870             


Leu Ala  Gly 
    3875     


<210>  52
<211>  3989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCS

<400>  52

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gly Glu 
    1055                 1060                 1065             


Pro Phe  Pro Leu Ala Pro Met  Gln His Ala Met Trp  Val Gly Arg 
    1070                 1075                 1080             


His Asp  His Gln Gln Leu Gly  Gly Val Ala Gly His  Leu Tyr Val 
    1085                 1090                 1095             


Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp Arg Leu  Arg Ala Ala 
    1100                 1105                 1110             


Ala Thr  Arg Leu Ala Leu Arg  His Pro Met Leu Arg  Val Gln Phe 
    1115                 1120                 1125             


Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro Ala Ala  Gly Ser Arg 
    1130                 1135                 1140             


Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg His Val  Ala Pro Asp 
    1145                 1150                 1155             


Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg Asp Ala  Lys Ser His 
    1160                 1165                 1170             


Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu Ala Leu  Thr Leu Leu 
    1175                 1180                 1185             


Pro Gly  Glu Arg Thr Arg Leu  His Val Asp Leu Asp  Met Gln Ala 
    1190                 1195                 1200             


Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu Ala Asp  Leu Ala Ala 
    1205                 1210                 1215             


Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu Gly Tyr  Thr Tyr Arg 
    1220                 1225                 1230             


Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu Thr Leu  Pro Gln Pro 
    1235                 1240                 1245             


Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala Gln Arg  Ile Pro Gln 
    1250                 1255                 1260             


Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg Ala Gly  Gly Glu Arg 
    1265                 1270                 1275             


Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His Trp Leu  Asp Pro Gln 
    1280                 1285                 1290             


Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg Ala Arg  Gly Ile Thr 
    1295                 1300                 1305             


Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala Asn Val  Leu Ala Arg 
    1310                 1315                 1320             


Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn Leu Pro  Leu Phe Ser 
    1325                 1330                 1335             


Arg Gln  Ala Leu His Pro Asp  Val Asp Leu Leu Val  Gly Asp Phe 
    1340                 1345                 1350             


Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu Gly Asp  Thr Val Ser 
    1355                 1360                 1365             


Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe Thr Glu  Asp Trp Glu 
    1370                 1375                 1380             


His Arg  His Trp Ser Gly Val  Glu Leu Leu Arg Glu  Leu Lys Arg 
    1385                 1390                 1395             


Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val Val Phe  Thr Ser Asn 
    1400                 1405                 1410             


Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala Glu Ser  Pro Leu Gly 
    1415                 1420                 1425             


Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro Gln Val  Trp Ile Asp 
    1430                 1435                 1440             


His Leu  Ala Phe Glu His His  Gly Glu Val Trp Leu  Gln Trp Asp 
    1445                 1450                 1455             


Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu Val Glu  Thr Leu Phe 
    1460                 1465                 1470             


Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu Cys Asp  Asp Glu Ser 
    1475                 1480                 1485             


Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met Pro Ala  Ser Gln Arg 
    1490                 1495                 1500             


Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly Ala Pro  Ile Pro Glu 
    1505                 1510                 1515             


Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile Ala Leu  Gln Gln Pro 
    1520                 1525                 1530             


Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr Gln Trp  Asn Ser Tyr 
    1535                 1540                 1545             


Arg Glu  Met Arg Glu Gln Val  Val Ala Leu Ala Asn  Leu Leu Arg 
    1550                 1555                 1560             


Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val Ala Val  Ala Leu Pro 
    1565                 1570                 1575             


Arg Ser  Val Phe Leu Thr Leu  Ala Leu His Ala Ile  Val Glu Ala 
    1580                 1585                 1590             


Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly Tyr Pro  Asp Asp Arg 
    1595                 1600                 1605             


Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro Ser Leu  Leu Ile Thr 
    1610                 1615                 1620             


Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp Val Pro  Asn Leu Thr 
    1625                 1630                 1635             


Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro Gln Gly  Ser Ala Pro 
    1640                 1645                 1650             


Leu Gln  Leu Ser Gln Pro His  His Thr Ala Tyr Ile  Ile Phe Thr 
    1655                 1660                 1665             


Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val Met Val  Gly Gln Thr 
    1670                 1675                 1680             


Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln Asn His  Tyr Pro Leu 
    1685                 1690                 1695             


Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr Pro Cys  Ser Phe Asp 
    1700                 1705                 1710             


Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe Ile Ala  Gly Ala Lys 
    1715                 1720                 1725             


Leu Val  Met Ala Glu Pro Glu  Ala His Arg Asp Pro  Leu Ala Met 
    1730                 1735                 1740             


Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr Thr Thr  His Phe Val 
    1745                 1750                 1755             


Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser Leu Thr  Pro Gln Thr 
    1760                 1765                 1770             


Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln Val Phe  Cys Ser Gly 
    1775                 1780                 1785             


Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu Trp Gln  Gln Leu Thr 
    1790                 1795                 1800             


Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    1805                 1810                 1815             


Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu Glu Leu  Ala Gln Val 
    1820                 1825                 1830             


Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro Val Trp  Asn Thr Gly 
    1835                 1840                 1845             


Leu Arg  Ile Leu Asp Ala Met  Met His Pro Val Pro  Pro Gly Val 
    1850                 1855                 1860             


Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln Leu Ala  Gln Gly Tyr 
    1865                 1870                 1875             


Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg Phe Ile  Ala Asp Pro 
    1880                 1885                 1890             


Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr Gly Asp  Val Ala Arg 
    1895                 1900                 1905             


Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu Gly Arg  Ser Asp Asp 
    1910                 1915                 1920             


Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu Leu Gly  Glu Ile Asp 
    1925                 1930                 1935             


Arg Val  Met Gln Ala Leu Pro  Asp Val Glu Gln Ala  Val Ala Ser 
    1940                 1945                 1950             


Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly Asn Lys  His Leu Val 
    1955                 1960                 1965             


Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr Cys Thr  Glu Arg Ser 
    1970                 1975                 1980             


Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg Ser Phe  Leu Lys Glu 
    1985                 1990                 1995             


Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala Ile Val  Ile Leu Asp 
    2000                 2005                 2010             


Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu Asp Arg  Arg Ala Leu 
    2015                 2020                 2025             


Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu Asp Lys  Tyr Val Ala 
    2030                 2035                 2040             


Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser 
    2045                 2050                 2055             


Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala 
    2060                 2065                 2070             


Leu Gly  Gly His Ser Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu 
    2075                 2080                 2085             


Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro Gly Gln  Val Met Val 
    2090                 2095                 2100             


Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu 
    2105                 2110                 2115             


Pro Val  Glu Gln Pro Phe Val  His Ser Pro Glu Glu  Arg Tyr Arg 
    2120                 2125                 2130             


Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala Tyr Leu  Val Gly Arg 
    2135                 2140                 2145             


Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly Ser His  Phe Phe Val 
    2150                 2155                 2160             


Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His Arg Leu  Glu Lys Val 
    2165                 2170                 2175             


Trp Asn  Arg Leu Ile Ala Arg  His Asp Met Leu Arg  Ala Val Val 
    2180                 2185                 2190             


Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln Thr Pro  Pro Trp Val 
    2195                 2200                 2205             


Ile Pro  Ala His Ile Leu His  Ser Pro Glu Glu Ala  Leu Gln Val 
    2210                 2215                 2220             


Arg Asp  Arg Leu Ala His Gln  Val Leu Asn Pro Glu  Val Trp Pro 
    2225                 2230                 2235             


Val Phe  Asp Leu Gln Val Gly  Phe Val Asp Gly Met  Pro Ala Arg 
    2240                 2245                 2250             


Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu Asp Gly  Leu Ser Met 
    2255                 2260                 2265             


Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly Tyr Arg  Tyr Pro Gln 
    2270                 2275                 2280             


Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe Arg Asp  Tyr Leu Gln 
    2285                 2290                 2295             


Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp Ser Leu  Ala Trp Trp 
    2300                 2305                 2310             


Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala Pro Ala  Leu Pro Leu 
    2315                 2320                 2325             


Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro Arg Phe  Ala Arg Leu 
    2330                 2335                 2340             


Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg Arg Leu  Lys Gln Arg 
    2345                 2350                 2355             


Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala Val Leu  Leu Ser Val 
    2360                 2365                 2370             


Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala Gln Pro  Asp Phe Thr 
    2375                 2380                 2385             


Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro Leu His  Pro Gln Ile 
    2390                 2395                 2400             


Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu Met Leu  Leu Ser Trp 
    2405                 2410                 2415             


His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala Arg Leu  Leu Gln Gln 
    2420                 2425                 2430             


Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp Val Ser  Ala Ile Arg 
    2435                 2440                 2445             


Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn Val Pro  Ala Val Pro 
    2450                 2455                 2460             


Met Pro  Val Val Phe Thr Ser  Ala Leu Gly Phe Glu  Gln Asp Asn 
    2465                 2470                 2475             


Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro Val Trp  Gly Ile Ser 
    2480                 2485                 2490             


Gln Thr  Pro Gln Val Trp Leu  Asp His Gln Val Tyr  Glu Ser Glu 
    2495                 2500                 2505             


Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val Ala Ala  Leu Phe Pro 
    2510                 2515                 2520             


Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln Tyr Cys  Ala Leu Leu 
    2525                 2530                 2535             


Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp Gln Leu  Pro Leu Ala 
    2540                 2545                 2550             


Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu Arg Arg  Ala Arg Arg 
    2555                 2560                 2565             


Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile Ala Ala  Asp Lys Ser 
    2570                 2575                 2580             


Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg Glu Val  Val Gly Glu 
    2585                 2590                 2595             


Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
    2600                 2605                 2610             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    2615                 2620                 2625             


Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Val 
    2630                 2635                 2640             


Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala Leu Glu  Glu Lys Thr 
    2645                 2650                 2655             


Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    2660                 2665                 2670             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    2675                 2680                 2685             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    2690                 2695                 2700             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    2705                 2710                 2715             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    2720                 2725                 2730             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    2735                 2740                 2745             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    2750                 2755                 2760             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    2765                 2770                 2775             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    2780                 2785                 2790             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    2795                 2800                 2805             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    2810                 2815                 2820             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    2825                 2830                 2835             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    2840                 2845                 2850             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    2855                 2860                 2865             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    2870                 2875                 2880             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    2885                 2890                 2895             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    2900                 2905                 2910             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    2915                 2920                 2925             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    2930                 2935                 2940             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    2945                 2950                 2955             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    2960                 2965                 2970             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    2975                 2980                 2985             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    2990                 2995                 3000             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    3005                 3010                 3015             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    3020                 3025                 3030             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    3035                 3040                 3045             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    3050                 3055                 3060             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    3065                 3070                 3075             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    3080                 3085                 3090             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    3095                 3100                 3105             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    3110                 3115                 3120             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    3125                 3130                 3135             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    3140                 3145                 3150             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    3155                 3160                 3165             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    3170                 3175                 3180             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    3185                 3190                 3195             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    3200                 3205                 3210             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    3215                 3220                 3225             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    3230                 3235                 3240             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    3245                 3250                 3255             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    3260                 3265                 3270             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    3275                 3280                 3285             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    3290                 3295                 3300             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    3305                 3310                 3315             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    3320                 3325                 3330             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    3335                 3340                 3345             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    3350                 3355                 3360             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    3365                 3370                 3375             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    3380                 3385                 3390             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    3395                 3400                 3405             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    3410                 3415                 3420             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    3425                 3430                 3435             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    3440                 3445                 3450             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    3455                 3460                 3465             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    3470                 3475                 3480             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    3485                 3490                 3495             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    3500                 3505                 3510             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    3515                 3520                 3525             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    3530                 3535                 3540             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    3545                 3550                 3555             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    3560                 3565                 3570             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    3575                 3580                 3585             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    3590                 3595                 3600             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    3605                 3610                 3615             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    3620                 3625                 3630             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    3635                 3640                 3645             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    3650                 3655                 3660             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    3665                 3670                 3675             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    3680                 3685                 3690             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    3695                 3700                 3705             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    3710                 3715                 3720             


Pro Ile  Thr Ser Gly Glu Asp  Asn Pro Ile Pro Leu  Cys Gln Gly 
    3725                 3730                 3735             


Asp Gly  Glu Glu Met Ser Thr  Trp Leu Arg Arg Phe  Gly Pro Pro 
    3740                 3745                 3750             


Val Glu  His Arg Ala Arg Leu  Val Cys Phe Pro His  Ala Gly Ala 
    3755                 3760                 3765             


Ala Ala  Asp Ser Tyr Leu Asp  Leu Ala Arg Ala Leu  Ala Pro Glu 
    3770                 3775                 3780             


Ile Asp  Val His Ala Val Gln  Tyr Pro Gly Arg Gln  Asp Arg Arg 
    3785                 3790                 3795             


Asp Glu  Glu Pro Leu Gly Thr  Ala Gly Glu Ile Ala  Asp Glu Val 
    3800                 3805                 3810             


Ala Ala  Val Leu Arg Ala Ser  Gly Gly Asp Gly Pro  Phe Ala Leu 
    3815                 3820                 3825             


Phe Gly  His Ser Met Gly Ala  Leu Ile Ala Tyr Glu  Thr Ala Arg 
    3830                 3835                 3840             


Arg Leu  Glu Arg Glu Pro Gly  Gly Gly Pro Leu Arg  Leu Phe Val 
    3845                 3850                 3855             


Ser Gly  Gln Thr Ala Pro Arg  Val His Glu Arg Arg  Thr Asp Leu 
    3860                 3865                 3870             


Pro Gly  Asp Asp Gly Leu Val  Asp Glu Leu Arg Arg  Leu Gly Thr 
    3875                 3880                 3885             


Ser Glu  Ala Ala Leu Ala Asp  Glu Ala Leu Leu Ala  Met Ser Leu 
    3890                 3895                 3900             


Pro Val  Leu Arg Ala Asp Tyr  Arg Val Leu Arg Ser  Tyr Ala Trp 
    3905                 3910                 3915             


Ala Asp  Gly Pro Pro Leu Arg  Ala Gly Ile Thr Ala  Leu Cys Gly 
    3920                 3925                 3930             


Asp Ala  Asp Pro Leu Thr Ala  Thr Gly Asp Ala Glu  Arg Trp Leu 
    3935                 3940                 3945             


Gln His  Ser Val Ile Pro Gly  Arg Thr Arg Thr Phe  Pro Gly Gly 
    3950                 3955                 3960             


His Phe  Tyr Leu Gly Glu Gln  Val Thr Glu Val Ala  Gly Ala Val 
    3965                 3970                 3975             


Arg Arg  Asp Leu Leu Arg Ala  Gly Leu Ala Gly 
    3980                 3985                 


<210>  53
<211>  4422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHC

<400>  53

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Leu Pro  Val Glu Gln Pro Phe  Val His Ser Pro Glu  Glu Arg Tyr 
    2555                 2560                 2565             


Arg Pro  Phe Ala Leu Thr Asp  Val Gln Gln Ala Tyr  Leu Val Gly 
    2570                 2575                 2580             


Arg Gln  Pro Gly Phe Ala Leu  Gly Gly Val Gly Ser  His Phe Phe 
    2585                 2590                 2595             


Val Glu  Phe Glu Ile Ala Asp  Leu Asp Ile His Arg  Leu Glu Lys 
    2600                 2605                 2610             


Val Trp  Asn Arg Leu Ile Ala  Arg His Asp Met Leu  Arg Ala Val 
    2615                 2620                 2625             


Val Arg  Asp Gly Gln Gln Arg  Val Leu Glu Gln Thr  Pro Pro Trp 
    2630                 2635                 2640             


Val Ile  Pro Ala His Ile Leu  His Ser Pro Glu Glu  Ala Leu Gln 
    2645                 2650                 2655             


Val Arg  Asp Arg Leu Ala His  Gln Val Leu Asn Pro  Glu Val Trp 
    2660                 2665                 2670             


Pro Val  Phe Asp Leu Gln Val  Gly Phe Val Asp Gly  Met Pro Ala 
    2675                 2680                 2685             


Arg Leu  Trp Leu Cys Leu Asp  Asn Leu Leu Leu Asp  Gly Leu Ser 
    2690                 2695                 2700             


Met Gln  Ile Leu Leu Ser Glu  Leu Glu His Gly Tyr  Arg Tyr Pro 
    2705                 2710                 2715             


Gln Gln  Leu Pro Pro Pro Leu  Pro Ile Thr Phe Arg  Asp Tyr Leu 
    2720                 2725                 2730             


Gln Gln  Pro Ala Leu Arg Thr  Pro Asn Pro Asp Ser  Leu Ala Trp 
    2735                 2740                 2745             


Trp Gln  Thr Gln Leu Asp Asp  Ile Pro Pro Ala Pro  Ala Leu Pro 
    2750                 2755                 2760             


Leu Arg  Cys Leu Pro Gln Asp  Val Glu Thr Pro Arg  Phe Ala Arg 
    2765                 2770                 2775             


Leu Tyr  Gly Ala Met Asp Ser  Ala Arg Trp Arg Arg  Leu Lys Gln 
    2780                 2785                 2790             


Arg Ala  Ala Asp Ala His Leu  Thr Pro Ser Ala Val  Leu Leu Ser 
    2795                 2800                 2805             


Val Trp  Ser Thr Val Leu Ala  Ala Trp Ser Ala Gln  Pro Asp Phe 
    2810                 2815                 2820             


Thr Leu  Asn Leu Thr Leu Phe  Asp Arg Arg Pro Leu  His Pro Gln 
    2825                 2830                 2835             


Ile Asn  Gln Ile Leu Gly Asp  Phe Thr Ser Leu Met  Leu Leu Ser 
    2840                 2845                 2850             


Trp His  Pro Gly Glu Ser Trp  Leu Gln Ser Ala Arg  Leu Leu Gln 
    2855                 2860                 2865             


Gln Arg  Leu Ser Glu Ser Leu  Asn His Arg Asp Val  Ser Ala Ile 
    2870                 2875                 2880             


Arg Val  Met Arg Gln Leu Ala  Arg Arg Gln Asn Val  Pro Ala Val 
    2885                 2890                 2895             


Pro Met  Pro Val Val Phe Thr  Ser Ala Leu Gly Phe  Glu Gln Asp 
    2900                 2905                 2910             


Asn Phe  Leu Ala Arg Arg Asn  Leu Leu Lys Pro Val  Trp Gly Ile 
    2915                 2920                 2925             


Ser Gln  Thr Pro Gln Val Trp  Leu Asp His Gln Val  Tyr Glu Ser 
    2930                 2935                 2940             


Glu Gly  Glu Leu Arg Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe 
    2945                 2950                 2955             


Pro Asp  Gly Gln Val Glu Arg  Gln Phe Ala Gln Tyr  Cys Ala Leu 
    2960                 2965                 2970             


Leu Asn  Arg Met Ala Glu Asp  Asp Ser Ser Trp Gln  Leu Pro Leu 
    2975                 2980                 2985             


Ala Asp  Leu Val Pro Pro Leu  Lys Val Thr Glu Arg  Arg Ala Arg 
    2990                 2995                 3000             


Arg Leu  Arg Pro Glu Arg Ala  Gln Pro Arg Ile Ala  Ala Asp Lys 
    3005                 3010                 3015             


Ser Ser  Val Ser Leu Ile Cys  Asp Thr Phe Arg Glu  Val Val Gly 
    3020                 3025                 3030             


Glu Pro  Val Ala Pro Ala Glu  Asn Phe Phe Glu Ala  Gly Ala Thr 
    3035                 3040                 3045             


Ser Leu  Asn Leu Val Gln Leu  His Val Leu Leu Gln  Arg His Glu 
    3050                 3055                 3060             


Phe Ala  Thr Leu Thr Leu Leu  Asp Leu Phe Thr His  Pro Ser Pro 
    3065                 3070                 3075             


Val Ala  Leu Ala Asn Tyr Leu  Ala Gly Val Ala Leu  Glu Glu Lys 
    3080                 3085                 3090             


Thr Lys  Arg Val Arg Pro Val  Arg Arg Arg Gln Arg  Arg Ile Gly 
    3095                 3100                 3105             


Glu Pro  Phe Pro Leu Ala Pro  Met Gln His Ala Met  Trp Val Gly 
    3110                 3115                 3120             


Arg His  Asp His Gln Gln Leu  Gly Gly Val Ala Gly  His Leu Tyr 
    3125                 3130                 3135             


Val Glu  Phe Asp Gly Ala Arg  Val Asp Pro Asp Arg  Leu Arg Ala 
    3140                 3145                 3150             


Ala Ala  Thr Arg Leu Ala Leu  Arg His Pro Met Leu  Arg Val Gln 
    3155                 3160                 3165             


Phe Leu  Pro Asp Gly Thr Gln  Arg Ile Pro Pro Ala  Ala Gly Ser 
    3170                 3175                 3180             


Arg Asp  Phe Pro Ile Ser Val  Ala Asp Leu Arg His  Val Ala Pro 
    3185                 3190                 3195             


Asp Val  Val Asp Gln Arg Leu  Ala Gly Ile Arg Asp  Ala Lys Ser 
    3200                 3205                 3210             


His Gln  Gln Leu Asp Gly Ala  Val Phe Glu Leu Ala  Leu Thr Leu 
    3215                 3220                 3225             


Leu Pro  Gly Glu Arg Thr Arg  Leu His Val Asp Leu  Asp Met Gln 
    3230                 3235                 3240             


Ala Ala  Asp Ala Met Ser Tyr  Arg Ile Leu Leu Ala  Asp Leu Ala 
    3245                 3250                 3255             


Ala Leu  Tyr Asp Gly Arg Glu  Pro Pro Ala Leu Gly  Tyr Thr Tyr 
    3260                 3265                 3270             


Arg Glu  Tyr Arg Gln Ala Ile  Glu Ala Glu Glu Thr  Leu Pro Gln 
    3275                 3280                 3285             


Pro Val  Arg Asp Ala Asp Arg  Asp Trp Trp Ala Gln  Arg Ile Pro 
    3290                 3295                 3300             


Gln Leu  Pro Asp Pro Pro Ala  Leu Pro Thr Arg Ala  Gly Gly Glu 
    3305                 3310                 3315             


Arg Asp  Arg Arg Arg Ser Thr  Arg Arg Trp His Trp  Leu Asp Pro 
    3320                 3325                 3330             


Gln Thr  Arg Asp Ala Leu Phe  Ala Arg Ala Arg Ala  Arg Gly Ile 
    3335                 3340                 3345             


Thr Pro  Ala Met Thr Leu Ala  Ala Ala Phe Ala Asn  Val Leu Ala 
    3350                 3355                 3360             


Arg Trp  Ser Ala Ser Ser Arg  Phe Leu Leu Asn Leu  Pro Leu Phe 
    3365                 3370                 3375             


Ser Arg  Gln Ala Leu His Pro  Asp Val Asp Leu Leu  Val Gly Asp 
    3380                 3385                 3390             


Phe Thr  Ser Ser Leu Leu Leu  Asp Val Asp Leu Gly  Asp Thr Val 
    3395                 3400                 3405             


Ser Asn  Leu Ala Arg Lys Asn  Gln Leu Thr Phe Thr  Glu Asp Trp 
    3410                 3415                 3420             


Glu His  Arg His Trp Ser Gly  Val Glu Leu Leu Arg  Glu Leu Lys 
    3425                 3430                 3435             


Arg Gln  Gln Arg Tyr Pro His  Gly Ala Pro Val Val  Phe Thr Ser 
    3440                 3445                 3450             


Asn Leu  Gly Arg Ser Leu Tyr  Ser Ser Arg Ala Glu  Ser Pro Leu 
    3455                 3460                 3465             


Gly Glu  Pro Glu Trp Gly Ile  Ser Gln Thr Pro Gln  Val Trp Ile 
    3470                 3475                 3480             


Asp His  Leu Ala Phe Glu His  His Gly Glu Val Trp  Leu Gln Trp 
    3485                 3490                 3495             


Asp Ser  Asn Asp Ala Leu Phe  Pro Pro Ala Leu Val  Glu Thr Leu 
    3500                 3505                 3510             


Phe Asp  Ala Tyr Cys Gln Leu  Ile Asn Gln Leu Cys  Asp Asp Glu 
    3515                 3520                 3525             


Ser Ala  Trp Gln Lys Pro Phe  Ala Asp Met Met Pro  Ala Ser Gln 
    3530                 3535                 3540             


Arg Ala  Ile Arg Glu Arg Val  Asn Ala Thr Gly Ala  Pro Ile Pro 
    3545                 3550                 3555             


Glu Gly  Leu Leu His Glu Gly  Ile Phe Arg Ile Ala  Leu Gln Gln 
    3560                 3565                 3570             


Pro Gln  Ala Leu Ala Val Thr  Asp Met Arg Tyr Gln  Trp Asn Ser 
    3575                 3580                 3585             


Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala Leu Ala  Asn Leu Leu 
    3590                 3595                 3600             


Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser Val Ala  Val Ala Leu 
    3605                 3610                 3615             


Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu His Ala  Ile Val Glu 
    3620                 3625                 3630             


Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr Gly Tyr  Pro Asp Asp 
    3635                 3640                 3645             


Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg Pro Ser  Leu Leu Ile 
    3650                 3655                 3660             


Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser Asp Val  Pro Asn Leu 
    3665                 3670                 3675             


Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr Pro Gln  Gly Ser Ala 
    3680                 3685                 3690             


Pro Leu  Gln Leu Ser Gln Pro  His His Thr Ala Tyr  Ile Ile Phe 
    3695                 3700                 3705             


Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly Val Met  Val Gly Gln 
    3710                 3715                 3720             


Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met Gln Asn  His Tyr Pro 
    3725                 3730                 3735             


Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys Thr Pro  Cys Ser Phe 
    3740                 3745                 3750             


Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro Phe Ile  Ala Gly Ala 
    3755                 3760                 3765             


Lys Leu  Val Met Ala Glu Pro  Glu Ala His Arg Asp  Pro Leu Ala 
    3770                 3775                 3780             


Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val Thr Thr  Thr His Phe 
    3785                 3790                 3795             


Val Pro  Ser Met Leu Ala Ala  Phe Val Ala Ser Leu  Thr Pro Gln 
    3800                 3805                 3810             


Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys Gln Val  Phe Cys Ser 
    3815                 3820                 3825             


Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg Glu Trp  Gln Gln Leu 
    3830                 3835                 3840             


Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly Pro Thr  Glu Ala Ala 
    3845                 3850                 3855             


Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly Glu Glu  Leu Ala Gln 
    3860                 3865                 3870             


Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr Pro Val  Trp Asn Thr 
    3875                 3880                 3885             


Gly Leu  Arg Ile Leu Asp Ala  Met Met His Pro Val  Pro Pro Gly 
    3890                 3895                 3900             


Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile Gln Leu  Ala Gln Gly 
    3905                 3910                 3915             


Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser Arg Phe  Ile Ala Asp 
    3920                 3925                 3930             


Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg Thr Gly  Asp Val Ala 
    3935                 3940                 3945             


Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr Leu Gly  Arg Ser Asp 
    3950                 3955                 3960             


Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile Glu Leu  Gly Glu Ile 
    3965                 3970                 3975             


Asp Arg  Val Met Gln Ala Leu  Pro Asp Val Glu Gln  Ala Val Ala 
    3980                 3985                 3990             


Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro Gly Asn  Lys His Leu 
    3995                 4000                 4005             


Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln Thr Cys  Thr Glu Arg 
    4010                 4015                 4020             


Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val Arg Ser  Phe Leu Lys 
    4025                 4030                 4035             


Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser Ala Ile  Val Ile Leu 
    4040                 4045                 4050             


Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys Leu Asp  Arg Arg Ala 
    4055                 4060                 4065             


Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu Leu Asp  Lys Tyr Val 
    4070                 4075                 4080             


Ala Pro  Arg Asn Pro Ile Glu  Thr Ile Ile Ala Ala  Ala Phe Ser 
    4085                 4090                 4095             


Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala Asp Ala  Asp Phe Phe 
    4100                 4105                 4110             


Ala Leu  Gly Gly His Ser Leu  Leu Ala Met Lys Leu  Ala Ala Gln 
    4115                 4120                 4125             


Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr Pro Gly  Gln Val Met 
    4130                 4135                 4140             


Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr Ile Ile  Asp Ala Glu 
    4145                 4150                 4155             


Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly 
    4160                 4165                 4170             


Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu 
    4175                 4180                 4185             


His Arg  Ala Arg Leu Val Cys  Phe Pro His Ala Gly  Ala Ala Ala 
    4190                 4195                 4200             


Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp 
    4205                 4210                 4215             


Val His  Ala Val Gln Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu 
    4220                 4225                 4230             


Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala 
    4235                 4240                 4245             


Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly 
    4250                 4255                 4260             


His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu 
    4265                 4270                 4275             


Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly 
    4280                 4285                 4290             


Gln Thr  Ala Pro Arg Val His  Glu Arg Arg Thr Asp  Leu Pro Gly 
    4295                 4300                 4305             


Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu 
    4310                 4315                 4320             


Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val 
    4325                 4330                 4335             


Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp 
    4340                 4345                 4350             


Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala 
    4355                 4360                 4365             


Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His 
    4370                 4375                 4380             


Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe 
    4385                 4390                 4395             


Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala Gly Ala  Val Arg Arg 
    4400                 4405                 4410             


Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    4415                 4420         


<210>  54
<211>  4863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHH

<400>  54

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro Val Val  Ile Ala Ala 
    2555                 2560                 2565             


Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val Ser Met  Ala Cys Arg 
    2570                 2575                 2580             


Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg Leu Trp  Glu Leu Leu 
    2585                 2590                 2595             


Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe Pro Thr  Asp Arg Gly 
    2600                 2605                 2610             


Trp Asp  Leu Ala Arg Leu His  His Pro Asp Pro Asp  Asn Pro Gly 
    2615                 2620                 2625             


Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu Asp Asp  Ala Ala Gly 
    2630                 2635                 2640             


Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro Arg Glu  Ala Ala Ala 
    2645                 2650                 2655             


Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu Thr Ser  Trp Glu Leu 
    2660                 2665                 2670             


Val Glu  Asn Ala Gly Ile Asp  Pro His Ser Leu Arg  Gly Thr Ala 
    2675                 2680                 2685             


Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe Gly Tyr  Gly Glu Asp 
    2690                 2695                 2700             


Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr Ser Val  Thr Gly Val 
    2705                 2710                 2715             


Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser Tyr Thr  Met Gly Leu 
    2720                 2725                 2730             


Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala Cys Ser  Ser Ser Leu 
    2735                 2740                 2745             


Val Ala  Leu His Leu Ala Val  Glu Ser Leu Arg Lys  Gly Glu Ser 
    2750                 2755                 2760             


Ser Met  Ala Val Val Gly Gly  Ala Ala Val Met Ala  Thr Pro Gly 
    2765                 2770                 2775             


Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala Leu Ala  Ala Asp Gly 
    2780                 2785                 2790             


Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp Gly Phe  Gly Phe Ser 
    2795                 2800                 2805             


Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg Leu Ser  Glu Ala Arg 
    2810                 2815                 2820             


Arg Asn  Gly His Glu Val Leu  Ala Val Val Arg Gly  Ser Ala Leu 
    2825                 2830                 2835             


Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser Ala Pro  Ser Gly Pro 
    2840                 2845                 2850             


Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu Glu Ser  Cys Gly Leu 
    2855                 2860                 2865             


Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala His Gly  Thr Gly Thr 
    2870                 2875                 2880             


Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala Leu Leu  Asp Thr Tyr 
    2885                 2890                 2895             


Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu Trp Leu  Gly Ser Val 
    2900                 2905                 2910             


Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala Ala Gly  Val Thr Gly 
    2915                 2920                 2925             


Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn Gly Glu  Leu Pro Ala 
    2930                 2935                 2940             


Thr Leu  His Val Glu Glu Pro  Thr Pro His Val Asp  Trp Ser Ser 
    2945                 2950                 2955             


Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln Pro Trp  Arg Arg Gly 
    2960                 2965                 2970             


Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala Phe Gly  Ile Ser Gly 
    2975                 2980                 2985             


Thr Asn  Ala His Val Ile Val  Glu Glu Ala Pro Gln  Glu Val Arg 
    2990                 2995                 3000             


Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala Val Ser  Thr Leu Val 
    3005                 3010                 3015             


Val Ala  Gly Lys Thr Met Gln  Arg Val Ser Ala Thr  Ala Gly Met 
    3020                 3025                 3030             


Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala Asp Val  Ala Leu Ala 
    3035                 3040                 3045             


Asp Val  Ala His Thr Leu Asn  His His Arg Ser Arg  Gln Pro Lys 
    3050                 3055                 3060             


Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr Gln Ala  Ile Ala Gly 
    3065                 3070                 3075             


Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala Pro Gly  Val Val Asn 
    3080                 3085                 3090             


Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr Val Phe  Val Phe Pro 
    3095                 3100                 3105             


Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly Glu Glu  Leu Ala Ala 
    3110                 3115                 3120             


Ala Phe  Pro Val Phe Ala Arg  Ile His Gln Gln Val  Trp Asp Leu 
    3125                 3130                 3135             


Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu Thr Gly  Tyr Ala Gln 
    3140                 3145                 3150             


Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu Phe Gly  Leu Leu Glu 
    3155                 3160                 3165             


Ser Trp  Gly Val Arg Pro Asp  Ala Val Val Gly His  Ser Val Gly 
    3170                 3175                 3180             


Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu Trp Ser  Leu Glu Asp 
    3185                 3190                 3195             


Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg Leu Met  Gln Ala Leu 
    3200                 3205                 3210             


Pro Ala  Gly Gly Val Met Ala  Ala Val Pro Val Ser  Glu Asp Glu 
    3215                 3220                 3225             


Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu Ile Ala  Ala Val Asn 
    3230                 3235                 3240             


Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp Glu Ala  Ala Val Leu 
    3245                 3250                 3255             


Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr Arg Leu  Pro Thr Ser 
    3260                 3265                 3270             


His Ala  Phe His Ser Ala Arg  Met Glu Pro Met Leu  Glu Glu Phe 
    3275                 3280                 3285             


Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg Thr Pro  Gln Val Ala 
    3290                 3295                 3300             


Met Ala  Ala Gly Asp Gln Val  Met Thr Ala Glu Tyr  Trp Val Arg 
    3305                 3310                 3315             


Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu Gln Val  Ala Ser Phe 
    3320                 3325                 3330             


Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala Asp Arg  Ser Leu Ala 
    3335                 3340                 3345             


Arg Leu  Val Asp Gly Ile Ala  Met Leu His Gly Asp  His Glu Ala 
    3350                 3355                 3360             


Gln Ala  Gly Met Arg Arg Glu  Gln Pro Leu Pro Leu  Gly Leu Arg 
    3365                 3370                 3375             


Arg Leu  Leu Thr Asp Leu His  Asn Ala Gly Ala Ala  Val Asp Phe 
    3380                 3385                 3390             


Ser Val  Leu Cys Pro Gln Gly  Arg Leu Val Asp Ala  Pro Leu Pro 
    3395                 3400                 3405             


Ala Trp  Ser His Arg Phe Leu  Phe Tyr Asp Arg Glu  Gly Val Asp 
    3410                 3415                 3420             


Asn Arg  Ser Pro Gly Gly Ser  Thr Val Ala Val His  Pro Leu Leu 
    3425                 3430                 3435             


Leu Ala  Ala Val Asp Val Pro  Gly His Gly Gly Ala  Val Phe Thr 
    3440                 3445                 3450             


Gly Arg  Leu Ser Thr Asp Glu  Gln Pro Trp Leu Ala  Glu His Val 
    3455                 3460                 3465             


Val Gly  Gly Arg Thr Leu Val  Pro Gly Ser Val Leu  Val Asp Leu 
    3470                 3475                 3480             


Ala Leu  Ala Ala Gly Glu Asp  Val Gly Leu Pro Val  Leu Glu Glu 
    3485                 3490                 3495             


Leu Val  Leu Gln Arg Pro Leu  Val Leu Ala Gly Ala  Gly Ala Leu 
    3500                 3505                 3510             


Leu Arg  Met Ser Val Gly Ala  Pro Asp Glu Ser Gly  Arg Arg Thr 
    3515                 3520                 3525             


Ile Asp  Val His Ala Ala Glu  Asp Val Ala Asp Leu  Ala Asp Ala 
    3530                 3535                 3540             


Gln Trp  Ser Gln His Ala Thr  Gly Thr Leu Ala Gln  Gly Val Ala 
    3545                 3550                 3555             


Ala Gly  Pro Arg Asp Thr Glu  Gln Trp Pro Pro Glu  Asp Ala Val 
    3560                 3565                 3570             


Arg Ile  Pro Leu Asp Asp His  Tyr Asp Gly Leu Ala  Glu Gln Gly 
    3575                 3580                 3585             


Tyr Glu  Tyr Gly Pro Ser Phe  Gln Ala Leu Val Ala  Tyr Val Ala 
    3590                 3595                 3600             


Glu Asp  Ala Thr Ala Thr Met  Leu Ala Glu Val Ala  Leu Pro Gly 
    3605                 3610                 3615             


Ser Ile  Arg Ser Gln Gln Gly  Leu Tyr Ala Ile His  Pro Ala Leu 
    3620                 3625                 3630             


Leu Asp  Ala Cys Phe Gln Ser  Val Gly Ala His Pro  Asp Ser Gln 
    3635                 3640                 3645             


Ser Val  Gly Ser Gly Leu Leu  Val Pro Leu Gly Val  Arg Arg Val 
    3650                 3655                 3660             


Arg Ala  Tyr Ala Pro Val Arg  Thr Ala Arg Tyr Cys  Tyr Thr Arg 
    3665                 3670                 3675             


Val Thr  Lys Val Glu Leu Ala  Gly Val Glu Ala Asp  Ile Asp Val 
    3680                 3685                 3690             


Leu Asp  Ala His Gly Thr Val  Leu Leu Ala Val Cys  Gly Leu Arg 
    3695                 3700                 3705             


Ile Gly  Thr Gly Val Ser Glu  Arg Asp Lys His Asn  Arg Val Leu 
    3710                 3715                 3720             


Asn Glu  Arg Leu Leu Thr Ile  Glu Trp His Gln Arg  Glu Leu Pro 
    3725                 3730                 3735             


Glu Met  Asp Pro Ser Gly Ala  Gly Lys Trp Leu Leu  Ile Ser Asp 
    3740                 3745                 3750             


Cys Ala  Ala Ser Asp Val Thr  Ala Thr Arg Leu Ala  Asp Ala Phe 
    3755                 3760                 3765             


Arg Glu  His Ser Ala Ala Cys  Thr Thr Met Arg Trp  Pro Leu His 
    3770                 3775                 3780             


Asp Asp  Gln Leu Ala Ala Ala  Asp Gln Leu Arg Asp  Gln Val Gly 
    3785                 3790                 3795             


Ser Asp  Glu Phe Ser Gly Val  Val Val Leu Thr Gly  Pro Asn Thr 
    3800                 3805                 3810             


Gly Thr  Pro His Gln Gly Ser  Ala Asp Arg Gly Ala  Glu Tyr Val 
    3815                 3820                 3825             


Arg Arg  Leu Val Gly Ile Ala  Arg Glu Leu Ser Asp  Leu Pro Gly 
    3830                 3835                 3840             


Ala Val  Pro Arg Met Tyr Val  Val Thr Arg Gly Ala  Gln Arg Val 
    3845                 3850                 3855             


Leu Ala  Asp Asp Cys Val Asn  Leu Glu Gln Gly Gly  Leu Arg Gly 
    3860                 3865                 3870             


Leu Leu  Arg Thr Ile Gly Ala  Glu His Pro His Leu  Arg Ala Thr 
    3875                 3880                 3885             


Gln Ile  Asp Val Asp Glu Gln  Thr Gly Val Glu Gln  Leu Ala Arg 
    3890                 3895                 3900             


Gln Leu  Leu Ala Thr Ser Glu  Glu Asp Glu Thr Ala  Trp Arg Asp 
    3905                 3910                 3915             


Asn Glu  Trp Tyr Val Ala Arg  Leu Cys Pro Thr Pro  Leu Arg Pro 
    3920                 3925                 3930             


Gln Glu  Arg Arg Thr Ile Val  Ala Asp His Gln Gln  Ser Gly Met 
    3935                 3940                 3945             


Arg Leu  Gln Ile Arg Thr Pro  Gly Ala Ile Asp Ser  Val Ala Phe 
    3950                 3955                 3960             


Glu Pro  Ala Pro Asp Val Glu  Gln Pro Leu Arg Ala  Gly Glu Val 
    3965                 3970                 3975             


Arg Val  Asp Val Arg Ala Thr  Gly Val Asn Phe Arg  Asp Val Leu 
    3980                 3985                 3990             


Leu Ala  Leu Gly Met Tyr Pro  Gln Lys Ala Asp Met  Gly Thr Glu 
    3995                 4000                 4005             


Ala Ala  Gly Val Val Thr Ala  Val Gly Pro Asp Val  Asp Ala Phe 
    4010                 4015                 4020             


Ala Pro  Gly Asp Arg Val Leu  Gly Leu Phe Gln Gly  Ala Phe Ala 
    4025                 4030                 4035             


Pro Ile  Ala Val Thr Asp His  Arg Leu Leu Ala Arg  Val Pro Asp 
    4040                 4045                 4050             


Gly Trp  Ser Asp Ala Asp Ala  Ala Ala Val Pro Ile  Ala Tyr Thr 
    4055                 4060                 4065             


Thr Ala  His Tyr Ala Leu His  Asp Leu Ala Gly Leu  Arg Ala Gly 
    4070                 4075                 4080             


Gln Ser  Val Leu Ile His Ala  Ala Ala Gly Gly Val  Gly Met Ala 
    4085                 4090                 4095             


Ala Val  Ala Leu Ala Arg Arg  Ala Gly Ala Glu Val  Leu Ala Thr 
    4100                 4105                 4110             


Ala Gly  Pro Ala Lys His Gly  Thr Leu Arg Ala Leu  Gly Leu Asp 
    4115                 4120                 4125             


Asp Glu  His Ile Ala Ser Ser  Arg Glu Thr Gly Phe  Ala Arg Lys 
    4130                 4135                 4140             


Phe Arg  Glu Arg Thr Gly Gly  Arg Gly Val Asp Val  Val Leu Asn 
    4145                 4150                 4155             


Ser Leu  Thr Gly Glu Leu Leu  Asp Glu Ser Ala Asp  Leu Leu Ala 
    4160                 4165                 4170             


Glu Asp  Gly Val Phe Val Glu  Met Gly Lys Thr Asp  Leu Arg Asp 
    4175                 4180                 4185             


Ala Gly  Asp Phe Arg Gly Arg  Tyr Ala Pro Phe Asp  Leu Gly Glu 
    4190                 4195                 4200             


Ala Gly  Asp Asp Arg Leu Gly  Glu Ile Leu Arg Glu  Val Val Gly 
    4205                 4210                 4215             


Leu Leu  Gly Ala Gly Glu Leu  Asp Arg Leu Pro Val  Ser Ala Trp 
    4220                 4225                 4230             


Glu Leu  Gly Ile Pro Gln Thr  Gly Lys Ser Leu Val  Thr Leu Pro 
    4235                 4240                 4245             


Pro Glu  Gln Ala Gln Val Phe  Arg Pro Asp Gly Thr  Val Leu Ile 
    4250                 4255                 4260             


Thr Gly  Gly Thr Gly Thr Leu  Gly Arg Leu Leu Ala  Arg His Leu 
    4265                 4270                 4275             


Val Thr  Glu His Gly Val Arg  His Leu Leu Leu Val  Ser Arg Arg 
    4280                 4285                 4290             


Gly Ala  Asp Ala Pro Gly Ser  Asp Glu Leu Arg Ala  Glu Ile Glu 
    4295                 4300                 4305             


Asp Leu  Gly Ala Ser Ala Glu  Ile Ala Ala Cys Asp  Thr Ala Asp 
    4310                 4315                 4320             


Arg Asp  Ala Leu Ser Ala Leu  Leu Asp Gly Leu Pro  Arg Pro Leu 
    4325                 4330                 4335             


Thr Gly  Val Val His Ala Ala  Gly Val Leu Ala Asp  Gly Leu Val 
    4340                 4345                 4350             


Thr Ser  Ile Asp Glu Pro Ala  Val Glu Gln Val Leu  Arg Ala Lys 
    4355                 4360                 4365             


Val Asp  Ala Ala Trp Asn Leu  His Glu Leu Thr Ala  Asn Thr Gly 
    4370                 4375                 4380             


Leu Ser  Phe Phe Val Leu Phe  Ser Ser Ala Ala Ser  Val Leu Ala 
    4385                 4390                 4395             


Gly Pro  Gly Gln Gly Val Tyr  Ala Ala Ala Asn Glu  Ser Leu Asn 
    4400                 4405                 4410             


Ala Leu  Ala Ala Leu Arg Arg  Thr Arg Gly Leu Pro  Ala Lys Ala 
    4415                 4420                 4425             


Leu Gly  Trp Gly Leu Trp Ala  Ile Gly Arg Ala Ile  Ala Phe Ala 
    4430                 4435                 4440             


Glu Gln  Thr Gly Asp Ala Ile  Ala Pro Glu Glu Gly  Ala Tyr Ala 
    4445                 4450                 4455             


Phe Glu  Thr Leu Leu Arg His  Asn Arg Ala Tyr Ser  Gly Tyr Ala 
    4460                 4465                 4470             


Pro Val  Ile Gly Ser Pro Trp  Leu Thr Ala Phe Ala  Gln His Ser 
    4475                 4480                 4485             


Pro Phe  Ala Glu Lys Phe Gln  Ser Leu Gly Gln Asn  Arg Ser Gly 
    4490                 4495                 4500             


Thr Ser  Lys Phe Leu Ala Glu  Leu Val Asp Leu Pro  Arg Glu Glu 
    4505                 4510                 4515             


Trp Pro  Asp Arg Leu Arg Arg  Leu Leu Glu Leu Val  Arg Ser His 
    4520                 4525                 4530             


Ala Ala  Ala Val Ser Gly Tyr  Gly Ser Ala Asp Gln  Leu Pro Glu 
    4535                 4540                 4545             


Arg Lys  Ala Phe Lys Asp Leu  Gly Phe Asp Ser Leu  Ala Ala Val 
    4550                 4555                 4560             


Glu Leu  Arg Asn Arg Leu Gly  Thr Ala Thr Gly Val  Arg Leu Pro 
    4565                 4570                 4575             


Ser Thr  Leu Val Phe Asp His  Pro Thr Pro Leu Ala  Val Ala Glu 
    4580                 4585                 4590             


His Leu  Arg Asp Arg Leu Thr  Ser Gly Glu Asp Asn  Pro Ile Pro 
    4595                 4600                 4605             


Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg 
    4610                 4615                 4620             


Phe Gly  Pro Pro Val Glu His  Arg Ala Arg Leu Val  Cys Phe Pro 
    4625                 4630                 4635             


His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala 
    4640                 4645                 4650             


Leu Ala  Pro Glu Ile Asp Val  His Ala Val Gln Tyr  Pro Gly Arg 
    4655                 4660                 4665             


Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile 
    4670                 4675                 4680             


Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly 
    4685                 4690                 4695             


Pro Phe  Ala Leu Phe Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr 
    4700                 4705                 4710             


Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu 
    4715                 4720                 4725             


Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro Arg Val  His Glu Arg 
    4730                 4735                 4740             


Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg 
    4745                 4750                 4755             


Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu 
    4760                 4765                 4770             


Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg 
    4775                 4780                 4785             


Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr 
    4790                 4795                 4800             


Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala 
    4805                 4810                 4815             


Glu Arg  Trp Leu Gln His Ser  Val Ile Pro Gly Arg  Thr Arg Thr 
    4820                 4825                 4830             


Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val 
    4835                 4840                 4845             


Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    4850                 4855                 4860             


<210>  55
<211>  4312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHO

<400>  55

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro Val Val  Ile Ala Ala 
    2555                 2560                 2565             


Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val Ser Met  Ala Cys Arg 
    2570                 2575                 2580             


Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg Leu Trp  Glu Leu Leu 
    2585                 2590                 2595             


Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe Pro Thr  Asp Arg Gly 
    2600                 2605                 2610             


Trp Asp  Leu Ala Arg Leu His  His Pro Asp Pro Asp  Asn Pro Gly 
    2615                 2620                 2625             


Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu Asp Asp  Ala Ala Gly 
    2630                 2635                 2640             


Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro Arg Glu  Ala Ala Ala 
    2645                 2650                 2655             


Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu Thr Ser  Trp Glu Leu 
    2660                 2665                 2670             


Val Glu  Asn Ala Gly Ile Asp  Pro His Ser Leu Arg  Gly Thr Ala 
    2675                 2680                 2685             


Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe Gly Tyr  Gly Glu Asp 
    2690                 2695                 2700             


Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr Ser Val  Thr Gly Val 
    2705                 2710                 2715             


Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser Tyr Thr  Met Gly Leu 
    2720                 2725                 2730             


Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala Cys Ser  Ser Ser Leu 
    2735                 2740                 2745             


Val Ala  Leu His Leu Ala Val  Glu Ser Leu Arg Lys  Gly Glu Ser 
    2750                 2755                 2760             


Ser Met  Ala Val Val Gly Gly  Ala Ala Val Met Ala  Thr Pro Gly 
    2765                 2770                 2775             


Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala Leu Ala  Ala Asp Gly 
    2780                 2785                 2790             


Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp Gly Phe  Gly Phe Ser 
    2795                 2800                 2805             


Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg Leu Ser  Glu Ala Arg 
    2810                 2815                 2820             


Arg Asn  Gly His Glu Val Leu  Ala Val Val Arg Gly  Ser Ala Leu 
    2825                 2830                 2835             


Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser Ala Pro  Ser Gly Pro 
    2840                 2845                 2850             


Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu Glu Ser  Cys Gly Leu 
    2855                 2860                 2865             


Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala His Gly  Thr Gly Thr 
    2870                 2875                 2880             


Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala Leu Leu  Asp Thr Tyr 
    2885                 2890                 2895             


Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu Trp Leu  Gly Ser Val 
    2900                 2905                 2910             


Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala Ala Gly  Val Thr Gly 
    2915                 2920                 2925             


Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn Gly Glu  Leu Pro Ala 
    2930                 2935                 2940             


Thr Leu  His Val Glu Glu Pro  Thr Pro His Val Asp  Trp Ser Ser 
    2945                 2950                 2955             


Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln Pro Trp  Arg Arg Gly 
    2960                 2965                 2970             


Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala Phe Gly  Ile Ser Gly 
    2975                 2980                 2985             


Thr Asn  Ala His Val Ile Val  Glu Glu Ala Pro Gln  Glu Val Arg 
    2990                 2995                 3000             


Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala Val Ser  Thr Leu Val 
    3005                 3010                 3015             


Val Ala  Gly Lys Thr Met Gln  Arg Val Ser Ala Thr  Ala Gly Met 
    3020                 3025                 3030             


Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala Asp Val  Ala Leu Ala 
    3035                 3040                 3045             


Asp Val  Ala His Thr Leu Asn  His His Arg Ser Arg  Gln Pro Lys 
    3050                 3055                 3060             


Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr Gln Ala  Ile Ala Gly 
    3065                 3070                 3075             


Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala Pro Gly  Val Val Asn 
    3080                 3085                 3090             


Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr Val Phe  Val Phe Pro 
    3095                 3100                 3105             


Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly Glu Glu  Leu Ala Ala 
    3110                 3115                 3120             


Ala Phe  Pro Val Phe Ala Arg  Ile His Gln Gln Val  Trp Asp Leu 
    3125                 3130                 3135             


Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu Thr Gly  Tyr Ala Gln 
    3140                 3145                 3150             


Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu Phe Gly  Leu Leu Glu 
    3155                 3160                 3165             


Ser Trp  Gly Val Arg Pro Asp  Ala Val Val Gly His  Ser Val Gly 
    3170                 3175                 3180             


Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu Trp Ser  Leu Glu Asp 
    3185                 3190                 3195             


Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg Leu Met  Gln Ala Leu 
    3200                 3205                 3210             


Pro Ala  Gly Gly Val Met Ala  Ala Val Pro Val Ser  Glu Asp Glu 
    3215                 3220                 3225             


Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu Ile Ala  Ala Val Asn 
    3230                 3235                 3240             


Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp Glu Ala  Ala Val Leu 
    3245                 3250                 3255             


Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr Arg Leu  Pro Thr Ser 
    3260                 3265                 3270             


His Ala  Phe His Ser Ala Arg  Met Glu Pro Met Leu  Glu Glu Phe 
    3275                 3280                 3285             


Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg Thr Pro  Gln Val Ala 
    3290                 3295                 3300             


Met Ala  Ala Gly Asp Gln Val  Met Thr Ala Glu Tyr  Trp Val Arg 
    3305                 3310                 3315             


Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu Gln Val  Ala Ser Phe 
    3320                 3325                 3330             


Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala Asp Arg  Ser Leu Ala 
    3335                 3340                 3345             


Arg Leu  Val Asp Gly Ile Ala  Met Leu His Gly Asp  His Glu Ala 
    3350                 3355                 3360             


Gln Ala  Ala Asp His Arg Gln  Ile Thr Glu Ala Val  Ala Asp Ala 
    3365                 3370                 3375             


Tyr Val  Leu Gly His Leu Pro  Asp Phe Ala Ala Leu  Arg Arg Pro 
    3380                 3385                 3390             


His Ala  Arg Lys Leu Asp Leu  Pro Thr Tyr Pro Phe  Glu Arg Arg 
    3395                 3400                 3405             


Gln Tyr  Trp Phe Arg Asp Ala  Arg Glu Arg Pro Glu  Gln Pro Arg 
    3410                 3415                 3420             


Asp Thr  Gly Gly Pro Arg Thr  Glu Ala Val Arg Leu  Leu Glu Asp 
    3425                 3430                 3435             


Gly Arg  Ile Glu Glu Leu Ala  Ala Leu Leu Gly Gly  Ala Ser Asp 
    3440                 3445                 3450             


Asp Gln  His Thr Leu Gln Val  Leu Thr Lys Leu Ala  Ala Gln His 
    3455                 3460                 3465             


Asn Gln  Gln Arg Thr Thr Arg  Ser Ile Ala Asp Asp  Arg Tyr Glu 
    3470                 3475                 3480             


Ile Arg  Trp Asp Arg Ser Thr  Ser Pro Leu Ser Gly  Ala Asp Val 
    3485                 3490                 3495             


Asp Gln  Ala Gly Ser Trp Ile  Val Val Ser Asp Asp  Ala Asp Ala 
    3500                 3505                 3510             


Val Pro  Pro Leu Val Asp Leu  Leu Ala Ala Arg Asn  Glu Pro His 
    3515                 3520                 3525             


Gln Val  Val Gly Leu Pro Ala  Ser Asp Ala Asp Glu  Glu Arg Leu 
    3530                 3535                 3540             


Ala Glu  Thr Leu Arg Ala Ala  Ala Thr Glu Asp Ala  Thr Leu Arg 
    3545                 3550                 3555             


Ile Val  His Val Ala Ala Leu  Glu Ala Gly Ala Thr  Pro Ser Met 
    3560                 3565                 3570             


Arg Ser  Leu Leu Arg Met Gln  His Arg Ile Leu Gly  Gly Thr Arg 
    3575                 3580                 3585             


Arg Val  Phe Arg Ala Ala Val  Ala Ala Glu Leu Arg  Gly Pro Ile 
    3590                 3595                 3600             


Trp Ile  Val Thr Arg Gly Ala  Gln Arg Val Ala Asp  Thr Asp Thr 
    3605                 3610                 3615             


Val Ala  Pro His Gln Ser Cys  Leu Trp Gly Phe Gly  Arg Ala Ala 
    3620                 3625                 3630             


Ser Leu  Glu Leu Pro His Val  Trp Gly Gly Leu Ala  Asp Leu Ser 
    3635                 3640                 3645             


Glu Gly  Gly Asp Asn Ala Ala  Asp Glu Trp Ser Ala  Leu Val Asp 
    3650                 3655                 3660             


Arg Ile  Ala Ala Pro His Gly  Ser Ala Val Arg Glu  Asp Gln Leu 
    3665                 3670                 3675             


Ala Leu  Arg Asp Arg Ala Val  Tyr Thr Pro Arg Leu  Ala Arg Arg 
    3680                 3685                 3690             


Ser Ala  Pro Pro Ser Gly Thr  Pro Leu His Leu Arg  Gly Asp Gly 
    3695                 3700                 3705             


Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu 
    3710                 3715                 3720             


Ala Arg  His Leu Val Thr Glu  His Gly Val Arg His  Leu Leu Leu 
    3725                 3730                 3735             


Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg 
    3740                 3745                 3750             


Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys 
    3755                 3760                 3765             


Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu 
    3770                 3775                 3780             


Pro Arg  Pro Leu Thr Gly Val  Val His Ala Ala Gly  Val Leu Ala 
    3785                 3790                 3795             


Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val 
    3800                 3805                 3810             


Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr 
    3815                 3820                 3825             


Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala 
    3830                 3835                 3840             


Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn 
    3845                 3850                 3855             


Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu 
    3860                 3865                 3870             


Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala 
    3875                 3880                 3885             


Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu 
    3890                 3895                 3900             


Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr 
    3905                 3910                 3915             


Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe 
    3920                 3925                 3930             


Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln 
    3935                 3940                 3945             


Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu 
    3950                 3955                 3960             


Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu 
    3965                 3970                 3975             


Val Arg  Ser His Ala Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp 
    3980                 3985                 3990             


Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser 
    3995                 4000                 4005             


Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly 
    4010                 4015                 4020             


Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp His Pro  Thr Pro Leu 
    4025                 4030                 4035             


Ala Val  Ala Glu His Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp 
    4040                 4045                 4050             


Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr 
    4055                 4060                 4065             


Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu His Arg  Ala Arg Leu 
    4070                 4075                 4080             


Val Cys  Phe Pro His Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp 
    4085                 4090                 4095             


Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp Val His  Ala Val Gln 
    4100                 4105                 4110             


Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr 
    4115                 4120                 4125             


Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser 
    4130                 4135                 4140             


Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly His Ser  Met Gly Ala 
    4145                 4150                 4155             


Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly 
    4160                 4165                 4170             


Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg 
    4175                 4180                 4185             


Val His  Glu Arg Arg Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val 
    4190                 4195                 4200             


Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp 
    4205                 4210                 4215             


Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr 
    4220                 4225                 4230             


Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg 
    4235                 4240                 4245             


Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala 
    4250                 4255                 4260             


Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His Ser Val  Ile Pro Gly 
    4265                 4270                 4275             


Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln 
    4280                 4285                 4290             


Val Thr  Glu Val Ala Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala 
    4295                 4300                 4305             


Gly Leu  Ala Gly 
    4310         


<210>  56
<211>  4425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MHS

<400>  56

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Leu Pro  Val Glu Gln Pro Phe  Val His Ser Pro Glu  Glu Arg Tyr 
    2555                 2560                 2565             


Arg Pro  Phe Ala Leu Thr Asp  Val Gln Gln Ala Tyr  Leu Val Gly 
    2570                 2575                 2580             


Arg Gln  Pro Gly Phe Ala Leu  Gly Gly Val Gly Ser  His Phe Phe 
    2585                 2590                 2595             


Val Glu  Phe Glu Ile Ala Asp  Leu Asp Ile His Arg  Leu Glu Lys 
    2600                 2605                 2610             


Val Trp  Asn Arg Leu Ile Ala  Arg His Asp Met Leu  Arg Ala Val 
    2615                 2620                 2625             


Val Arg  Asp Gly Gln Gln Arg  Val Leu Glu Gln Thr  Pro Pro Trp 
    2630                 2635                 2640             


Val Ile  Pro Ala His Ile Leu  His Ser Pro Glu Glu  Ala Leu Gln 
    2645                 2650                 2655             


Val Arg  Asp Arg Leu Ala His  Gln Val Leu Asn Pro  Glu Val Trp 
    2660                 2665                 2670             


Pro Val  Phe Asp Leu Gln Val  Gly Phe Val Asp Gly  Met Pro Ala 
    2675                 2680                 2685             


Arg Leu  Trp Leu Cys Leu Asp  Asn Leu Leu Leu Asp  Gly Leu Ser 
    2690                 2695                 2700             


Met Gln  Ile Leu Leu Ser Glu  Leu Glu His Gly Tyr  Arg Tyr Pro 
    2705                 2710                 2715             


Gln Gln  Leu Pro Pro Pro Leu  Pro Ile Thr Phe Arg  Asp Tyr Leu 
    2720                 2725                 2730             


Gln Gln  Pro Ala Leu Arg Thr  Pro Asn Pro Asp Ser  Leu Ala Trp 
    2735                 2740                 2745             


Trp Gln  Thr Gln Leu Asp Asp  Ile Pro Pro Ala Pro  Ala Leu Pro 
    2750                 2755                 2760             


Leu Arg  Cys Leu Pro Gln Asp  Val Glu Thr Pro Arg  Phe Ala Arg 
    2765                 2770                 2775             


Leu Tyr  Gly Ala Met Asp Ser  Ala Arg Trp Arg Arg  Leu Lys Gln 
    2780                 2785                 2790             


Arg Ala  Ala Asp Ala His Leu  Thr Pro Ser Ala Val  Leu Leu Ser 
    2795                 2800                 2805             


Val Trp  Ser Thr Val Leu Ala  Ala Trp Ser Ala Gln  Pro Asp Phe 
    2810                 2815                 2820             


Thr Leu  Asn Leu Thr Leu Phe  Asp Arg Arg Pro Leu  His Pro Gln 
    2825                 2830                 2835             


Ile Asn  Gln Ile Leu Gly Asp  Phe Thr Ser Leu Met  Leu Leu Ser 
    2840                 2845                 2850             


Trp His  Pro Gly Glu Ser Trp  Leu Gln Ser Ala Arg  Leu Leu Gln 
    2855                 2860                 2865             


Gln Arg  Leu Ser Glu Ser Leu  Asn His Arg Asp Val  Ser Ala Ile 
    2870                 2875                 2880             


Arg Val  Met Arg Gln Leu Ala  Arg Arg Gln Asn Val  Pro Ala Val 
    2885                 2890                 2895             


Pro Met  Pro Val Val Phe Thr  Ser Ala Leu Gly Phe  Glu Gln Asp 
    2900                 2905                 2910             


Asn Phe  Leu Ala Arg Arg Asn  Leu Leu Lys Pro Val  Trp Gly Ile 
    2915                 2920                 2925             


Ser Gln  Thr Pro Gln Val Trp  Leu Asp His Gln Val  Tyr Glu Ser 
    2930                 2935                 2940             


Glu Gly  Glu Leu Arg Phe Asn  Trp Asp Phe Val Ala  Ala Leu Phe 
    2945                 2950                 2955             


Pro Asp  Gly Gln Val Glu Arg  Gln Phe Ala Gln Tyr  Cys Ala Leu 
    2960                 2965                 2970             


Leu Asn  Arg Met Ala Glu Asp  Asp Ser Ser Trp Gln  Leu Pro Leu 
    2975                 2980                 2985             


Ala Asp  Leu Val Pro Pro Leu  Lys Val Thr Glu Arg  Arg Ala Arg 
    2990                 2995                 3000             


Arg Leu  Arg Pro Glu Arg Ala  Gln Pro Arg Ile Ala  Ala Asp Lys 
    3005                 3010                 3015             


Ser Ser  Val Ser Leu Ile Cys  Asp Thr Phe Arg Glu  Val Val Gly 
    3020                 3025                 3030             


Glu Pro  Val Ala Pro Ala Glu  Asn Phe Phe Glu Ala  Gly Ala Thr 
    3035                 3040                 3045             


Ser Leu  Asn Leu Val Gln Leu  His Val Leu Leu Gln  Arg His Glu 
    3050                 3055                 3060             


Phe Ala  Thr Leu Thr Leu Leu  Asp Leu Phe Thr His  Pro Ser Pro 
    3065                 3070                 3075             


Val Ala  Leu Ala Asn Tyr Leu  Ala Gly Val Ala Leu  Glu Glu Lys 
    3080                 3085                 3090             


Thr Lys  Arg Val Arg Pro Val  Arg Arg Arg Gln Arg  Arg Ile Gln 
    3095                 3100                 3105             


His Leu  Pro Leu Val Ala Ala  Gln Pro Gly Ile Trp  Met Ala Glu 
    3110                 3115                 3120             


Lys Leu  Ser Glu Leu Pro Ser  Ala Trp Ser Val Ala  His Tyr Val 
    3125                 3130                 3135             


Glu Leu  Thr Gly Glu Val Asp  Ser Pro Leu Leu Ala  Arg Ala Val 
    3140                 3145                 3150             


Val Ala  Gly Leu Ala Gln Ala  Asp Thr Leu Arg Met  Arg Phe Thr 
    3155                 3160                 3165             


Glu Asp  Asn Gly Glu Val Trp  Gln Trp Val Asp Asp  Ala Leu Thr 
    3170                 3175                 3180             


Phe Glu  Leu Pro Glu Ile Ile  Asp Leu Arg Thr Asn  Ile Asp Pro 
    3185                 3190                 3195             


His Gly  Thr Ala Gln Ala Leu  Met Gln Ala Asp Leu  Gln Gln Asp 
    3200                 3205                 3210             


Leu Arg  Val Asp Ser Gly Lys  Pro Leu Val Phe His  Gln Leu Ile 
    3215                 3220                 3225             


Gln Val  Ala Asp Asn Arg Trp  Tyr Trp Tyr Gln Arg  Tyr His His 
    3230                 3235                 3240             


Leu Leu  Val Asp Gly Phe Ser  Phe Pro Ala Ile Thr  Arg Gln Ile 
    3245                 3250                 3255             


Ala Asn  Ile Tyr Cys Thr Trp  Leu Arg Gly Glu Pro  Thr Pro Ala 
    3260                 3265                 3270             


Ser Pro  Phe Thr Pro Phe Ala  Asp Val Val Glu Glu  Tyr Gln Gln 
    3275                 3280                 3285             


Tyr Arg  Glu Ser Glu Ala Trp  Gln Arg Asp Ala Ala  Phe Trp Ala 
    3290                 3295                 3300             


Glu Gln  Arg Arg Gln Leu Pro  Pro Pro Ala Ser Leu  Ser Pro Ala 
    3305                 3310                 3315             


Pro Leu  Pro Gly Arg Ser Ala  Ser Ala Asp Ile Leu  Arg Leu Lys 
    3320                 3325                 3330             


Leu Glu  Phe Thr Asp Gly Glu  Phe Arg Gln Leu Ala  Thr Gln Leu 
    3335                 3340                 3345             


Ser Gly  Val Gln Arg Thr Asp  Leu Ala Leu Ala Leu  Ala Ala Leu 
    3350                 3355                 3360             


Trp Leu  Gly Arg Leu Cys Asn  Arg Met Asp Tyr Ala  Ala Gly Phe 
    3365                 3370                 3375             


Ile Phe  Met Arg Arg Leu Gly  Ser Ala Ala Leu Thr  Ala Thr Gly 
    3380                 3385                 3390             


Pro Val  Leu Asn Val Leu Pro  Leu Gly Ile His Ile  Gly Asn Pro 
    3395                 3400                 3405             


Ser Phe  Ser Glu Leu Leu Thr  Arg Val Arg Glu Val  Ala Leu Gly 
    3410                 3415                 3420             


Ala Tyr  Ala His Gln His Ile  Pro Phe Glu Met Leu  Val Glu Ala 
    3425                 3430                 3435             


Leu Gln  Pro Glu Arg Asn Leu  Ser His Thr Pro Leu  Phe Gln Val 
    3440                 3445                 3450             


Met Phe  Val Leu Gln Asn Ala  Pro Ala Ser Gln Leu  Glu Leu Thr 
    3455                 3460                 3465             


Gly Ile  Thr Ala Asn Pro Ile  Lys Val Lys Ser Thr  Thr Thr Lys 
    3470                 3475                 3480             


Phe Asp  Leu Thr Leu Ile Met  Gln Asn Thr Ala Ser  Gly Leu Val 
    3485                 3490                 3495             


Gly Val  Trp Glu Tyr Asn Thr  Asp Leu Phe Asp Ala  Ser Thr Ile 
    3500                 3505                 3510             


Glu Arg  Met Thr Gly His Phe  Val Thr Leu Leu Glu  Gly Val Ile 
    3515                 3520                 3525             


Ala Asn  Pro Gln Gln Pro Ile  Ser Gln Leu Pro Ile  Leu Thr Thr 
    3530                 3535                 3540             


Val Glu  Gln Gln Gln Leu Leu  Val Glu Trp Asn Asn  Thr Gln Thr 
    3545                 3550                 3555             


Asp Tyr  Pro Ala Asp Lys Cys  Ile His Gln Leu Phe  Glu Glu Gln 
    3560                 3565                 3570             


Val Glu  Arg Thr Pro Asp Ala  Val Ala Val Val Phe  Gly Asn Gln 
    3575                 3580                 3585             


Gln Leu  Ser Tyr Arg Glu Met  Arg Glu Gln Val Val  Ala Leu Ala 
    3590                 3595                 3600             


Asn Leu  Leu Arg Glu Arg Gly  Val Lys Pro Gly Asp  Ser Val Ala 
    3605                 3610                 3615             


Val Ala  Leu Pro Arg Ser Val  Phe Leu Thr Leu Ala  Leu His Ala 
    3620                 3625                 3630             


Ile Val  Glu Ala Gly Ala Ala  Trp Leu Pro Leu Asp  Thr Gly Tyr 
    3635                 3640                 3645             


Pro Asp  Asp Arg Leu Lys Met  Met Leu Glu Asp Ala  Arg Pro Ser 
    3650                 3655                 3660             


Leu Leu  Ile Thr Thr Asp Asp  Gln Leu Pro Arg Phe  Ser Asp Val 
    3665                 3670                 3675             


Pro Asn  Leu Thr Ser Leu Cys  Tyr Asn Ala Pro Leu  Thr Pro Gln 
    3680                 3685                 3690             


Gly Ser  Ala Pro Leu Gln Leu  Ser Gln Pro His His  Thr Ala Tyr 
    3695                 3700                 3705             


Ile Ile  Phe Thr Ser Gly Ser  Thr Gly Arg Pro Lys  Gly Val Met 
    3710                 3715                 3720             


Val Gly  Gln Thr Ala Ile Val  Asn Arg Leu Leu Trp  Met Gln Asn 
    3725                 3730                 3735             


His Tyr  Pro Leu Thr Gly Glu  Asp Val Val Ala Gln  Lys Thr Pro 
    3740                 3745                 3750             


Cys Ser  Phe Asp Val Ser Val  Trp Glu Phe Phe Trp  Pro Phe Ile 
    3755                 3760                 3765             


Ala Gly  Ala Lys Leu Val Met  Ala Glu Pro Glu Ala  His Arg Asp 
    3770                 3775                 3780             


Pro Leu  Ala Met Gln Gln Phe  Phe Ala Glu Tyr Gly  Val Thr Thr 
    3785                 3790                 3795             


Thr His  Phe Val Pro Ser Met  Leu Ala Ala Phe Val  Ala Ser Leu 
    3800                 3805                 3810             


Thr Pro  Gln Thr Ala Arg Gln  Ser Cys Ala Thr Leu  Lys Gln Val 
    3815                 3820                 3825             


Phe Cys  Ser Gly Glu Ala Leu  Pro Ala Asp Leu Cys  Arg Glu Trp 
    3830                 3835                 3840             


Gln Gln  Leu Thr Gly Ala Pro  Leu His Asn Leu Tyr  Gly Pro Thr 
    3845                 3850                 3855             


Glu Ala  Ala Val Asp Val Ser  Trp Tyr Pro Ala Phe  Gly Glu Glu 
    3860                 3865                 3870             


Leu Ala  Gln Val Arg Gly Ser  Ser Val Pro Ile Gly  Tyr Pro Val 
    3875                 3880                 3885             


Trp Asn  Thr Gly Leu Arg Ile  Leu Asp Ala Met Met  His Pro Val 
    3890                 3895                 3900             


Pro Pro  Gly Val Ala Gly Asp  Leu Tyr Leu Thr Gly  Ile Gln Leu 
    3905                 3910                 3915             


Ala Gln  Gly Tyr Leu Gly Arg  Pro Asp Leu Thr Ala  Ser Arg Phe 
    3920                 3925                 3930             


Ile Ala  Asp Pro Phe Ala Pro  Gly Glu Arg Met Tyr  Arg Thr Gly 
    3935                 3940                 3945             


Asp Val  Ala Arg Trp Leu Asp  Asn Gly Ala Val Glu  Tyr Leu Gly 
    3950                 3955                 3960             


Arg Ser  Asp Asp Gln Leu Lys  Ile Arg Gly Gln Arg  Ile Glu Leu 
    3965                 3970                 3975             


Gly Glu  Ile Asp Arg Val Met  Gln Ala Leu Pro Asp  Val Glu Gln 
    3980                 3985                 3990             


Ala Val  Ala Ser Cys Ala Ile  Ala Arg Glu Asp Ile  Pro Gly Asn 
    3995                 4000                 4005             


Lys His  Leu Val Ala Tyr Ile  Val Pro Gln Glu Glu  Gln Thr Cys 
    4010                 4015                 4020             


Thr Glu  Arg Ser Arg Ser Thr  Leu Thr Val Ser Phe  Val Arg Ser 
    4025                 4030                 4035             


Phe Leu  Lys Glu Lys Leu Pro  Glu Tyr Met Val Pro  Ser Ala Ile 
    4040                 4045                 4050             


Val Ile  Leu Asp Ala Leu Pro  Leu Thr Pro Asn Gly  Lys Leu Asp 
    4055                 4060                 4065             


Arg Arg  Ala Leu Pro Ala Pro  Asp Leu His Ser Gln  Leu Glu Thr 
    4070                 4075                 4080             


Ile Ile  Ala Ala Ala Phe Ser  Ser Leu Leu Gly Cys  Asp Val Gln 
    4085                 4090                 4095             


Asp Ala  Asp Ala Asp Phe Phe  Ala Leu Gly Gly His  Ser Leu Leu 
    4100                 4105                 4110             


Ala Met  Lys Leu Ala Ala Gln  Leu Ser Arg Gln Val  Ala Arg Gln 
    4115                 4120                 4125             


Val Thr  Pro Gly Gln Val Met  Val Ala Ser Thr Val  Ala Lys Leu 
    4130                 4135                 4140             


Ala Thr  Ile Ile Asp Ala Glu  Leu Asp Lys Tyr Val  Ala Pro Arg 
    4145                 4150                 4155             


Asn Pro  Ile Thr Ser Gly Glu  Asp Asn Pro Ile Pro  Leu Cys Gln 
    4160                 4165                 4170             


Gly Asp  Gly Glu Glu Met Ser  Thr Trp Leu Arg Arg  Phe Gly Pro 
    4175                 4180                 4185             


Pro Val  Glu His Arg Ala Arg  Leu Val Cys Phe Pro  His Ala Gly 
    4190                 4195                 4200             


Ala Ala  Ala Asp Ser Tyr Leu  Asp Leu Ala Arg Ala  Leu Ala Pro 
    4205                 4210                 4215             


Glu Ile  Asp Val His Ala Val  Gln Tyr Pro Gly Arg  Gln Asp Arg 
    4220                 4225                 4230             


Arg Asp  Glu Glu Pro Leu Gly  Thr Ala Gly Glu Ile  Ala Asp Glu 
    4235                 4240                 4245             


Val Ala  Ala Val Leu Arg Ala  Ser Gly Gly Asp Gly  Pro Phe Ala 
    4250                 4255                 4260             


Leu Phe  Gly His Ser Met Gly  Ala Leu Ile Ala Tyr  Glu Thr Ala 
    4265                 4270                 4275             


Arg Arg  Leu Glu Arg Glu Pro  Gly Gly Gly Pro Leu  Arg Leu Phe 
    4280                 4285                 4290             


Val Ser  Gly Gln Thr Ala Pro  Arg Val His Glu Arg  Arg Thr Asp 
    4295                 4300                 4305             


Leu Pro  Gly Asp Asp Gly Leu  Val Asp Glu Leu Arg  Arg Leu Gly 
    4310                 4315                 4320             


Thr Ser  Glu Ala Ala Leu Ala  Asp Glu Ala Leu Leu  Ala Met Ser 
    4325                 4330                 4335             


Leu Pro  Val Leu Arg Ala Asp  Tyr Arg Val Leu Arg  Ser Tyr Ala 
    4340                 4345                 4350             


Trp Ala  Asp Gly Pro Pro Leu  Arg Ala Gly Ile Thr  Ala Leu Cys 
    4355                 4360                 4365             


Gly Asp  Ala Asp Pro Leu Thr  Ala Thr Gly Asp Ala  Glu Arg Trp 
    4370                 4375                 4380             


Leu Gln  His Ser Val Ile Pro  Gly Arg Thr Arg Thr  Phe Pro Gly 
    4385                 4390                 4395             


Gly His  Phe Tyr Leu Gly Glu  Gln Val Thr Glu Val  Ala Gly Ala 
    4400                 4405                 4410             


Val Arg  Arg Asp Leu Leu Arg  Ala Gly Leu Ala Gly  
    4415                 4420                 4425 


<210>  57
<211>  3871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOC

<400>  57

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Leu Pro Val  Glu Gln Pro Phe Val  His Ser Pro 
    2000                 2005                 2010             


Glu Glu  Arg Tyr Arg Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala 
    2015                 2020                 2025             


Tyr Leu  Val Gly Arg Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly 
    2030                 2035                 2040             


Ser His  Phe Phe Val Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His 
    2045                 2050                 2055             


Arg Leu  Glu Lys Val Trp Asn  Arg Leu Ile Ala Arg  His Asp Met 
    2060                 2065                 2070             


Leu Arg  Ala Val Val Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln 
    2075                 2080                 2085             


Thr Pro  Pro Trp Val Ile Pro  Ala His Ile Leu His  Ser Pro Glu 
    2090                 2095                 2100             


Glu Ala  Leu Gln Val Arg Asp  Arg Leu Ala His Gln  Val Leu Asn 
    2105                 2110                 2115             


Pro Glu  Val Trp Pro Val Phe  Asp Leu Gln Val Gly  Phe Val Asp 
    2120                 2125                 2130             


Gly Met  Pro Ala Arg Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu 
    2135                 2140                 2145             


Asp Gly  Leu Ser Met Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly 
    2150                 2155                 2160             


Tyr Arg  Tyr Pro Gln Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe 
    2165                 2170                 2175             


Arg Asp  Tyr Leu Gln Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp 
    2180                 2185                 2190             


Ser Leu  Ala Trp Trp Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala 
    2195                 2200                 2205             


Pro Ala  Leu Pro Leu Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro 
    2210                 2215                 2220             


Arg Phe  Ala Arg Leu Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg 
    2225                 2230                 2235             


Arg Leu  Lys Gln Arg Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala 
    2240                 2245                 2250             


Val Leu  Leu Ser Val Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala 
    2255                 2260                 2265             


Gln Pro  Asp Phe Thr Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro 
    2270                 2275                 2280             


Leu His  Pro Gln Ile Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu 
    2285                 2290                 2295             


Met Leu  Leu Ser Trp His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala 
    2300                 2305                 2310             


Arg Leu  Leu Gln Gln Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp 
    2315                 2320                 2325             


Val Ser  Ala Ile Arg Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn 
    2330                 2335                 2340             


Val Pro  Ala Val Pro Met Pro  Val Val Phe Thr Ser  Ala Leu Gly 
    2345                 2350                 2355             


Phe Glu  Gln Asp Asn Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro 
    2360                 2365                 2370             


Val Trp  Gly Ile Ser Gln Thr  Pro Gln Val Trp Leu  Asp His Gln 
    2375                 2380                 2385             


Val Tyr  Glu Ser Glu Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val 
    2390                 2395                 2400             


Ala Ala  Leu Phe Pro Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln 
    2405                 2410                 2415             


Tyr Cys  Ala Leu Leu Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp 
    2420                 2425                 2430             


Gln Leu  Pro Leu Ala Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu 
    2435                 2440                 2445             


Arg Arg  Ala Arg Arg Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile 
    2450                 2455                 2460             


Ala Ala  Asp Lys Ser Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg 
    2465                 2470                 2475             


Glu Val  Val Gly Glu Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu 
    2480                 2485                 2490             


Ala Gly  Ala Thr Ser Leu Asn  Leu Val Gln Leu His  Val Leu Leu 
    2495                 2500                 2505             


Gln Arg  His Glu Phe Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr 
    2510                 2515                 2520             


His Pro  Ser Pro Val Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala 
    2525                 2530                 2535             


Leu Glu  Glu Lys Thr Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln 
    2540                 2545                 2550             


Arg Arg  Ile Gly Glu Pro Phe  Pro Leu Ala Pro Met  Gln His Ala 
    2555                 2560                 2565             


Met Trp  Val Gly Arg His Asp  His Gln Gln Leu Gly  Gly Val Ala 
    2570                 2575                 2580             


Gly His  Leu Tyr Val Glu Phe  Asp Gly Ala Arg Val  Asp Pro Asp 
    2585                 2590                 2595             


Arg Leu  Arg Ala Ala Ala Thr  Arg Leu Ala Leu Arg  His Pro Met 
    2600                 2605                 2610             


Leu Arg  Val Gln Phe Leu Pro  Asp Gly Thr Gln Arg  Ile Pro Pro 
    2615                 2620                 2625             


Ala Ala  Gly Ser Arg Asp Phe  Pro Ile Ser Val Ala  Asp Leu Arg 
    2630                 2635                 2640             


His Val  Ala Pro Asp Val Val  Asp Gln Arg Leu Ala  Gly Ile Arg 
    2645                 2650                 2655             


Asp Ala  Lys Ser His Gln Gln  Leu Asp Gly Ala Val  Phe Glu Leu 
    2660                 2665                 2670             


Ala Leu  Thr Leu Leu Pro Gly  Glu Arg Thr Arg Leu  His Val Asp 
    2675                 2680                 2685             


Leu Asp  Met Gln Ala Ala Asp  Ala Met Ser Tyr Arg  Ile Leu Leu 
    2690                 2695                 2700             


Ala Asp  Leu Ala Ala Leu Tyr  Asp Gly Arg Glu Pro  Pro Ala Leu 
    2705                 2710                 2715             


Gly Tyr  Thr Tyr Arg Glu Tyr  Arg Gln Ala Ile Glu  Ala Glu Glu 
    2720                 2725                 2730             


Thr Leu  Pro Gln Pro Val Arg  Asp Ala Asp Arg Asp  Trp Trp Ala 
    2735                 2740                 2745             


Gln Arg  Ile Pro Gln Leu Pro  Asp Pro Pro Ala Leu  Pro Thr Arg 
    2750                 2755                 2760             


Ala Gly  Gly Glu Arg Asp Arg  Arg Arg Ser Thr Arg  Arg Trp His 
    2765                 2770                 2775             


Trp Leu  Asp Pro Gln Thr Arg  Asp Ala Leu Phe Ala  Arg Ala Arg 
    2780                 2785                 2790             


Ala Arg  Gly Ile Thr Pro Ala  Met Thr Leu Ala Ala  Ala Phe Ala 
    2795                 2800                 2805             


Asn Val  Leu Ala Arg Trp Ser  Ala Ser Ser Arg Phe  Leu Leu Asn 
    2810                 2815                 2820             


Leu Pro  Leu Phe Ser Arg Gln  Ala Leu His Pro Asp  Val Asp Leu 
    2825                 2830                 2835             


Leu Val  Gly Asp Phe Thr Ser  Ser Leu Leu Leu Asp  Val Asp Leu 
    2840                 2845                 2850             


Gly Asp  Thr Val Ser Asn Leu  Ala Arg Lys Asn Gln  Leu Thr Phe 
    2855                 2860                 2865             


Thr Glu  Asp Trp Glu His Arg  His Trp Ser Gly Val  Glu Leu Leu 
    2870                 2875                 2880             


Arg Glu  Leu Lys Arg Gln Gln  Arg Tyr Pro His Gly  Ala Pro Val 
    2885                 2890                 2895             


Val Phe  Thr Ser Asn Leu Gly  Arg Ser Leu Tyr Ser  Ser Arg Ala 
    2900                 2905                 2910             


Glu Ser  Pro Leu Gly Glu Pro  Glu Trp Gly Ile Ser  Gln Thr Pro 
    2915                 2920                 2925             


Gln Val  Trp Ile Asp His Leu  Ala Phe Glu His His  Gly Glu Val 
    2930                 2935                 2940             


Trp Leu  Gln Trp Asp Ser Asn  Asp Ala Leu Phe Pro  Pro Ala Leu 
    2945                 2950                 2955             


Val Glu  Thr Leu Phe Asp Ala  Tyr Cys Gln Leu Ile  Asn Gln Leu 
    2960                 2965                 2970             


Cys Asp  Asp Glu Ser Ala Trp  Gln Lys Pro Phe Ala  Asp Met Met 
    2975                 2980                 2985             


Pro Ala  Ser Gln Arg Ala Ile  Arg Glu Arg Val Asn  Ala Thr Gly 
    2990                 2995                 3000             


Ala Pro  Ile Pro Glu Gly Leu  Leu His Glu Gly Ile  Phe Arg Ile 
    3005                 3010                 3015             


Ala Leu  Gln Gln Pro Gln Ala  Leu Ala Val Thr Asp  Met Arg Tyr 
    3020                 3025                 3030             


Gln Trp  Asn Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    3035                 3040                 3045             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    3050                 3055                 3060             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    3065                 3070                 3075             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    3080                 3085                 3090             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    3095                 3100                 3105             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    3110                 3115                 3120             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    3125                 3130                 3135             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    3140                 3145                 3150             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    3155                 3160                 3165             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    3170                 3175                 3180             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    3185                 3190                 3195             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    3200                 3205                 3210             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    3215                 3220                 3225             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    3230                 3235                 3240             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    3245                 3250                 3255             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    3260                 3265                 3270             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    3275                 3280                 3285             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    3290                 3295                 3300             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    3305                 3310                 3315             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    3320                 3325                 3330             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    3335                 3340                 3345             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    3350                 3355                 3360             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    3365                 3370                 3375             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    3380                 3385                 3390             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    3395                 3400                 3405             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    3410                 3415                 3420             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    3425                 3430                 3435             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    3440                 3445                 3450             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    3455                 3460                 3465             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    3470                 3475                 3480             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    3485                 3490                 3495             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    3500                 3505                 3510             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Leu 
    3515                 3520                 3525             


Asp Lys  Tyr Val Ala Pro Arg  Asn Pro Ile Glu Thr  Ile Ile Ala 
    3530                 3535                 3540             


Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp 
    3545                 3550                 3555             


Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser Leu Leu  Ala Met Lys 
    3560                 3565                 3570             


Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro 
    3575                 3580                 3585             


Gly Gln  Val Met Val Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile 
    3590                 3595                 3600             


Ile Asp  Ala Glu Thr Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys 
    3605                 3610                 3615             


Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly 
    3620                 3625                 3630             


Pro Pro  Val Glu His Arg Ala  Arg Leu Val Cys Phe  Pro His Ala 
    3635                 3640                 3645             


Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala 
    3650                 3655                 3660             


Pro Glu  Ile Asp Val His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp 
    3665                 3670                 3675             


Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp 
    3680                 3685                 3690             


Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe 
    3695                 3700                 3705             


Ala Leu  Phe Gly His Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr 
    3710                 3715                 3720             


Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu 
    3725                 3730                 3735             


Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val His Glu  Arg Arg Thr 
    3740                 3745                 3750             


Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu 
    3755                 3760                 3765             


Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met 
    3770                 3775                 3780             


Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr 
    3785                 3790                 3795             


Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu 
    3800                 3805                 3810             


Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg 
    3815                 3820                 3825             


Trp Leu  Gln His Ser Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro 
    3830                 3835                 3840             


Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly 
    3845                 3850                 3855             


Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3860                 3865                 3870     


<210>  58
<211>  4312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOH

<400>  58

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    2000                 2005                 2010             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    2015                 2020                 2025             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    2030                 2035                 2040             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    2045                 2050                 2055             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    2060                 2065                 2070             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    2075                 2080                 2085             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    2090                 2095                 2100             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    2105                 2110                 2115             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    2120                 2125                 2130             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    2135                 2140                 2145             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    2150                 2155                 2160             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    2165                 2170                 2175             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    2180                 2185                 2190             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    2195                 2200                 2205             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    2210                 2215                 2220             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    2225                 2230                 2235             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    2240                 2245                 2250             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    2255                 2260                 2265             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    2270                 2275                 2280             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    2285                 2290                 2295             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    2300                 2305                 2310             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2315                 2320                 2325             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2330                 2335                 2340             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2345                 2350                 2355             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2360                 2365                 2370             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2375                 2380                 2385             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2390                 2395                 2400             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2405                 2410                 2415             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2420                 2425                 2430             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2435                 2440                 2445             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2450                 2455                 2460             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2465                 2470                 2475             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2480                 2485                 2490             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2495                 2500                 2505             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2510                 2515                 2520             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2525                 2530                 2535             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2540                 2545                 2550             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2555                 2560                 2565             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2570                 2575                 2580             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2585                 2590                 2595             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2600                 2605                 2610             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2615                 2620                 2625             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2630                 2635                 2640             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2645                 2650                 2655             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2660                 2665                 2670             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2675                 2680                 2685             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2690                 2695                 2700             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2705                 2710                 2715             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2720                 2725                 2730             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2735                 2740                 2745             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2750                 2755                 2760             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2765                 2770                 2775             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2780                 2785                 2790             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2795                 2800                 2805             


Asp His  Glu Ala Gln Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro 
    2810                 2815                 2820             


Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala 
    2825                 2830                 2835             


Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp 
    2840                 2845                 2850             


Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg 
    2855                 2860                 2865             


Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val 
    2870                 2875                 2880             


His Pro  Leu Leu Leu Ala Ala  Val Asp Val Pro Gly  His Gly Gly 
    2885                 2890                 2895             


Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu 
    2900                 2905                 2910             


Ala Glu  His Val Val Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val 
    2915                 2920                 2925             


Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro 
    2930                 2935                 2940             


Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly 
    2945                 2950                 2955             


Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser 
    2960                 2965                 2970             


Gly Arg  Arg Thr Ile Asp Val  His Ala Ala Glu Asp  Val Ala Asp 
    2975                 2980                 2985             


Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala 
    2990                 2995                 3000             


Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro 
    3005                 3010                 3015             


Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu 
    3020                 3025                 3030             


Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val 
    3035                 3040                 3045             


Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val 
    3050                 3055                 3060             


Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile 
    3065                 3070                 3075             


His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln Ser Val  Gly Ala His 
    3080                 3085                 3090             


Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly 
    3095                 3100                 3105             


Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr 
    3110                 3115                 3120             


Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala 
    3125                 3130                 3135             


Asp Ile  Asp Val Leu Asp Ala  His Gly Thr Val Leu  Leu Ala Val 
    3140                 3145                 3150             


Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser Glu Arg  Asp Lys His 
    3155                 3160                 3165             


Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln 
    3170                 3175                 3180             


Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu 
    3185                 3190                 3195             


Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu 
    3200                 3205                 3210             


Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala Cys Thr  Thr Met Arg 
    3215                 3220                 3225             


Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg 
    3230                 3235                 3240             


Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly Val Val  Val Leu Thr 
    3245                 3250                 3255             


Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly 
    3260                 3265                 3270             


Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser 
    3275                 3280                 3285             


Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr Val Val  Thr Arg Gly 
    3290                 3295                 3300             


Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly 
    3305                 3310                 3315             


Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly Ala Glu  His Pro His 
    3320                 3325                 3330             


Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu 
    3335                 3340                 3345             


Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr 
    3350                 3355                 3360             


Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr 
    3365                 3370                 3375             


Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile Val Ala  Asp His Gln 
    3380                 3385                 3390             


Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp 
    3395                 3400                 3405             


Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg 
    3410                 3415                 3420             


Ala Gly  Glu Val Arg Val Asp  Val Arg Ala Thr Gly  Val Asn Phe 
    3425                 3430                 3435             


Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp 
    3440                 3445                 3450             


Met Gly  Thr Glu Ala Ala Gly  Val Val Thr Ala Val  Gly Pro Asp 
    3455                 3460                 3465             


Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln 
    3470                 3475                 3480             


Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp His Arg  Leu Leu Ala 
    3485                 3490                 3495             


Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro 
    3500                 3505                 3510             


Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu His Asp  Leu Ala Gly 
    3515                 3520                 3525             


Leu Arg  Ala Gly Gln Ser Val  Leu Ile His Ala Ala  Ala Gly Gly 
    3530                 3535                 3540             


Val Gly  Met Ala Ala Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu 
    3545                 3550                 3555             


Val Leu  Ala Thr Ala Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala 
    3560                 3565                 3570             


Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly 
    3575                 3580                 3585             


Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp 
    3590                 3595                 3600             


Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala 
    3605                 3610                 3615             


Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val Glu Met  Gly Lys Thr 
    3620                 3625                 3630             


Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe 
    3635                 3640                 3645             


Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg 
    3650                 3655                 3660             


Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro 
    3665                 3670                 3675             


Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu 
    3680                 3685                 3690             


Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly 
    3695                 3700                 3705             


Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu 
    3710                 3715                 3720             


Ala Arg  His Leu Val Thr Glu  His Gly Val Arg His  Leu Leu Leu 
    3725                 3730                 3735             


Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg 
    3740                 3745                 3750             


Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys 
    3755                 3760                 3765             


Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu 
    3770                 3775                 3780             


Pro Arg  Pro Leu Thr Gly Val  Val His Ala Ala Gly  Val Leu Ala 
    3785                 3790                 3795             


Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val 
    3800                 3805                 3810             


Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr 
    3815                 3820                 3825             


Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala 
    3830                 3835                 3840             


Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn 
    3845                 3850                 3855             


Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu 
    3860                 3865                 3870             


Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala 
    3875                 3880                 3885             


Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu 
    3890                 3895                 3900             


Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr 
    3905                 3910                 3915             


Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe 
    3920                 3925                 3930             


Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln 
    3935                 3940                 3945             


Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu 
    3950                 3955                 3960             


Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu 
    3965                 3970                 3975             


Val Arg  Ser His Ala Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp 
    3980                 3985                 3990             


Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser 
    3995                 4000                 4005             


Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly 
    4010                 4015                 4020             


Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp His Pro  Thr Pro Leu 
    4025                 4030                 4035             


Ala Val  Ala Glu His Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp 
    4040                 4045                 4050             


Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr 
    4055                 4060                 4065             


Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu His Arg  Ala Arg Leu 
    4070                 4075                 4080             


Val Cys  Phe Pro His Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp 
    4085                 4090                 4095             


Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp Val His  Ala Val Gln 
    4100                 4105                 4110             


Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr 
    4115                 4120                 4125             


Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser 
    4130                 4135                 4140             


Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly His Ser  Met Gly Ala 
    4145                 4150                 4155             


Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly 
    4160                 4165                 4170             


Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg 
    4175                 4180                 4185             


Val His  Glu Arg Arg Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val 
    4190                 4195                 4200             


Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp 
    4205                 4210                 4215             


Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr 
    4220                 4225                 4230             


Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg 
    4235                 4240                 4245             


Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala 
    4250                 4255                 4260             


Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His Ser Val  Ile Pro Gly 
    4265                 4270                 4275             


Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln 
    4280                 4285                 4290             


Val Thr  Glu Val Ala Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala 
    4295                 4300                 4305             


Gly Leu  Ala Gly 
    4310         


<210>  59
<211>  3761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOO

<400>  59

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    2000                 2005                 2010             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    2015                 2020                 2025             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    2030                 2035                 2040             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    2045                 2050                 2055             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    2060                 2065                 2070             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    2075                 2080                 2085             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    2090                 2095                 2100             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    2105                 2110                 2115             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    2120                 2125                 2130             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    2135                 2140                 2145             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    2150                 2155                 2160             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    2165                 2170                 2175             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    2180                 2185                 2190             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    2195                 2200                 2205             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    2210                 2215                 2220             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    2225                 2230                 2235             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    2240                 2245                 2250             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    2255                 2260                 2265             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    2270                 2275                 2280             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    2285                 2290                 2295             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    2300                 2305                 2310             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2315                 2320                 2325             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2330                 2335                 2340             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2345                 2350                 2355             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2360                 2365                 2370             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2375                 2380                 2385             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2390                 2395                 2400             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2405                 2410                 2415             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2420                 2425                 2430             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2435                 2440                 2445             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2450                 2455                 2460             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2465                 2470                 2475             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2480                 2485                 2490             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2495                 2500                 2505             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2510                 2515                 2520             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2525                 2530                 2535             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2540                 2545                 2550             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2555                 2560                 2565             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2570                 2575                 2580             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2585                 2590                 2595             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2600                 2605                 2610             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2615                 2620                 2625             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2630                 2635                 2640             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2645                 2650                 2655             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2660                 2665                 2670             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2675                 2680                 2685             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2690                 2695                 2700             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2705                 2710                 2715             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2720                 2725                 2730             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2735                 2740                 2745             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2750                 2755                 2760             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2765                 2770                 2775             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2780                 2785                 2790             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2795                 2800                 2805             


Asp His  Glu Ala Gln Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala 
    2810                 2815                 2820             


Val Ala  Asp Ala Tyr Val Leu  Gly His Leu Pro Asp  Phe Ala Ala 
    2825                 2830                 2835             


Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro 
    2840                 2845                 2850             


Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro 
    2855                 2860                 2865             


Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg 
    2870                 2875                 2880             


Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly 
    2885                 2890                 2895             


Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln Val Leu  Thr Lys Leu 
    2900                 2905                 2910             


Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp 
    2915                 2920                 2925             


Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser 
    2930                 2935                 2940             


Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp 
    2945                 2950                 2955             


Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg 
    2960                 2965                 2970             


Asn Glu  Pro His Gln Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp 
    2975                 2980                 2985             


Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp 
    2990                 2995                 3000             


Ala Thr  Leu Arg Ile Val His  Val Ala Ala Leu Glu  Ala Gly Ala 
    3005                 3010                 3015             


Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met Gln His  Arg Ile Leu 
    3020                 3025                 3030             


Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu 
    3035                 3040                 3045             


Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala 
    3050                 3055                 3060             


Asp Thr  Asp Thr Val Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe 
    3065                 3070                 3075             


Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His Val Trp  Gly Gly Leu 
    3080                 3085                 3090             


Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser 
    3095                 3100                 3105             


Ala Leu  Val Asp Arg Ile Ala  Ala Pro His Gly Ser  Ala Val Arg 
    3110                 3115                 3120             


Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg 
    3125                 3130                 3135             


Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu 
    3140                 3145                 3150             


Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    3155                 3160                 3165             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    3170                 3175                 3180             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    3185                 3190                 3195             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    3200                 3205                 3210             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    3215                 3220                 3225             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    3230                 3235                 3240             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    3245                 3250                 3255             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    3260                 3265                 3270             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    3275                 3280                 3285             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    3290                 3295                 3300             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    3305                 3310                 3315             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    3320                 3325                 3330             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    3335                 3340                 3345             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    3350                 3355                 3360             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    3365                 3370                 3375             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    3380                 3385                 3390             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    3395                 3400                 3405             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    3410                 3415                 3420             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    3425                 3430                 3435             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    3440                 3445                 3450             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    3455                 3460                 3465             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    3470                 3475                 3480             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Thr 
    3485                 3490                 3495             


Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu 
    3500                 3505                 3510             


Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly Pro Pro  Val Glu His 
    3515                 3520                 3525             


Arg Ala  Arg Leu Val Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp 
    3530                 3535                 3540             


Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val 
    3545                 3550                 3555             


His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu 
    3560                 3565                 3570             


Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val 
    3575                 3580                 3585             


Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His 
    3590                 3595                 3600             


Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu 
    3605                 3610                 3615             


Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln 
    3620                 3625                 3630             


Thr Ala  Pro Arg Val His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp 
    3635                 3640                 3645             


Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala 
    3650                 3655                 3660             


Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu 
    3665                 3670                 3675             


Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly 
    3680                 3685                 3690             


Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp 
    3695                 3700                 3705             


Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser 
    3710                 3715                 3720             


Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr 
    3725                 3730                 3735             


Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp 
    3740                 3745                 3750             


Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3755                 3760     


<210>  60
<211>  3874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOS

<400>  60

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Leu Pro Val  Glu Gln Pro Phe Val  His Ser Pro 
    2000                 2005                 2010             


Glu Glu  Arg Tyr Arg Pro Phe  Ala Leu Thr Asp Val  Gln Gln Ala 
    2015                 2020                 2025             


Tyr Leu  Val Gly Arg Gln Pro  Gly Phe Ala Leu Gly  Gly Val Gly 
    2030                 2035                 2040             


Ser His  Phe Phe Val Glu Phe  Glu Ile Ala Asp Leu  Asp Ile His 
    2045                 2050                 2055             


Arg Leu  Glu Lys Val Trp Asn  Arg Leu Ile Ala Arg  His Asp Met 
    2060                 2065                 2070             


Leu Arg  Ala Val Val Arg Asp  Gly Gln Gln Arg Val  Leu Glu Gln 
    2075                 2080                 2085             


Thr Pro  Pro Trp Val Ile Pro  Ala His Ile Leu His  Ser Pro Glu 
    2090                 2095                 2100             


Glu Ala  Leu Gln Val Arg Asp  Arg Leu Ala His Gln  Val Leu Asn 
    2105                 2110                 2115             


Pro Glu  Val Trp Pro Val Phe  Asp Leu Gln Val Gly  Phe Val Asp 
    2120                 2125                 2130             


Gly Met  Pro Ala Arg Leu Trp  Leu Cys Leu Asp Asn  Leu Leu Leu 
    2135                 2140                 2145             


Asp Gly  Leu Ser Met Gln Ile  Leu Leu Ser Glu Leu  Glu His Gly 
    2150                 2155                 2160             


Tyr Arg  Tyr Pro Gln Gln Leu  Pro Pro Pro Leu Pro  Ile Thr Phe 
    2165                 2170                 2175             


Arg Asp  Tyr Leu Gln Gln Pro  Ala Leu Arg Thr Pro  Asn Pro Asp 
    2180                 2185                 2190             


Ser Leu  Ala Trp Trp Gln Thr  Gln Leu Asp Asp Ile  Pro Pro Ala 
    2195                 2200                 2205             


Pro Ala  Leu Pro Leu Arg Cys  Leu Pro Gln Asp Val  Glu Thr Pro 
    2210                 2215                 2220             


Arg Phe  Ala Arg Leu Tyr Gly  Ala Met Asp Ser Ala  Arg Trp Arg 
    2225                 2230                 2235             


Arg Leu  Lys Gln Arg Ala Ala  Asp Ala His Leu Thr  Pro Ser Ala 
    2240                 2245                 2250             


Val Leu  Leu Ser Val Trp Ser  Thr Val Leu Ala Ala  Trp Ser Ala 
    2255                 2260                 2265             


Gln Pro  Asp Phe Thr Leu Asn  Leu Thr Leu Phe Asp  Arg Arg Pro 
    2270                 2275                 2280             


Leu His  Pro Gln Ile Asn Gln  Ile Leu Gly Asp Phe  Thr Ser Leu 
    2285                 2290                 2295             


Met Leu  Leu Ser Trp His Pro  Gly Glu Ser Trp Leu  Gln Ser Ala 
    2300                 2305                 2310             


Arg Leu  Leu Gln Gln Arg Leu  Ser Glu Ser Leu Asn  His Arg Asp 
    2315                 2320                 2325             


Val Ser  Ala Ile Arg Val Met  Arg Gln Leu Ala Arg  Arg Gln Asn 
    2330                 2335                 2340             


Val Pro  Ala Val Pro Met Pro  Val Val Phe Thr Ser  Ala Leu Gly 
    2345                 2350                 2355             


Phe Glu  Gln Asp Asn Phe Leu  Ala Arg Arg Asn Leu  Leu Lys Pro 
    2360                 2365                 2370             


Val Trp  Gly Ile Ser Gln Thr  Pro Gln Val Trp Leu  Asp His Gln 
    2375                 2380                 2385             


Val Tyr  Glu Ser Glu Gly Glu  Leu Arg Phe Asn Trp  Asp Phe Val 
    2390                 2395                 2400             


Ala Ala  Leu Phe Pro Asp Gly  Gln Val Glu Arg Gln  Phe Ala Gln 
    2405                 2410                 2415             


Tyr Cys  Ala Leu Leu Asn Arg  Met Ala Glu Asp Asp  Ser Ser Trp 
    2420                 2425                 2430             


Gln Leu  Pro Leu Ala Asp Leu  Val Pro Pro Leu Lys  Val Thr Glu 
    2435                 2440                 2445             


Arg Arg  Ala Arg Arg Leu Arg  Pro Glu Arg Ala Gln  Pro Arg Ile 
    2450                 2455                 2460             


Ala Ala  Asp Lys Ser Ser Val  Ser Leu Ile Cys Asp  Thr Phe Arg 
    2465                 2470                 2475             


Glu Val  Val Gly Glu Pro Val  Ala Pro Ala Glu Asn  Phe Phe Glu 
    2480                 2485                 2490             


Ala Gly  Ala Thr Ser Leu Asn  Leu Val Gln Leu His  Val Leu Leu 
    2495                 2500                 2505             


Gln Arg  His Glu Phe Ala Thr  Leu Thr Leu Leu Asp  Leu Phe Thr 
    2510                 2515                 2520             


His Pro  Ser Pro Val Ala Leu  Ala Asn Tyr Leu Ala  Gly Val Ala 
    2525                 2530                 2535             


Leu Glu  Glu Lys Thr Lys Arg  Val Arg Pro Val Arg  Arg Arg Gln 
    2540                 2545                 2550             


Arg Arg  Ile Gln His Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile 
    2555                 2560                 2565             


Trp Met  Ala Glu Lys Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val 
    2570                 2575                 2580             


Ala His  Tyr Val Glu Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu 
    2585                 2590                 2595             


Ala Arg  Ala Val Val Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg 
    2600                 2605                 2610             


Met Arg  Phe Thr Glu Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp 
    2615                 2620                 2625             


Asp Ala  Leu Thr Phe Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr 
    2630                 2635                 2640             


Asn Ile  Asp Pro His Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp 
    2645                 2650                 2655             


Leu Gln  Gln Asp Leu Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe 
    2660                 2665                 2670             


His Gln  Leu Ile Gln Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln 
    2675                 2680                 2685             


Arg Tyr  His His Leu Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile 
    2690                 2695                 2700             


Thr Arg  Gln Ile Ala Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu 
    2705                 2710                 2715             


Pro Thr  Pro Ala Ser Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu 
    2720                 2725                 2730             


Glu Tyr  Gln Gln Tyr Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala 
    2735                 2740                 2745             


Ala Phe  Trp Ala Glu Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser 
    2750                 2755                 2760             


Leu Ser  Pro Ala Pro Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile 
    2765                 2770                 2775             


Leu Arg  Leu Lys Leu Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu 
    2780                 2785                 2790             


Ala Thr  Gln Leu Ser Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala 
    2795                 2800                 2805             


Leu Ala  Ala Leu Trp Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr 
    2810                 2815                 2820             


Ala Ala  Gly Phe Ile Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu 
    2825                 2830                 2835             


Thr Ala  Thr Gly Pro Val Leu  Asn Val Leu Pro Leu  Gly Ile His 
    2840                 2845                 2850             


Ile Gly  Asn Pro Ser Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu 
    2855                 2860                 2865             


Val Ala  Leu Gly Ala Tyr Ala  His Gln His Ile Pro  Phe Glu Met 
    2870                 2875                 2880             


Leu Val  Glu Ala Leu Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro 
    2885                 2890                 2895             


Leu Phe  Gln Val Met Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln 
    2900                 2905                 2910             


Leu Glu  Leu Thr Gly Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser 
    2915                 2920                 2925             


Thr Thr  Thr Lys Phe Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala 
    2930                 2935                 2940             


Ser Gly  Leu Val Gly Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp 
    2945                 2950                 2955             


Ala Ser  Thr Ile Glu Arg Met  Thr Gly His Phe Val  Thr Leu Leu 
    2960                 2965                 2970             


Glu Gly  Val Ile Ala Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro 
    2975                 2980                 2985             


Ile Leu  Thr Thr Val Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn 
    2990                 2995                 3000             


Asn Thr  Gln Thr Asp Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu 
    3005                 3010                 3015             


Phe Glu  Glu Gln Val Glu Arg  Thr Pro Asp Ala Val  Ala Val Val 
    3020                 3025                 3030             


Phe Gly  Asn Gln Gln Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val 
    3035                 3040                 3045             


Val Ala  Leu Ala Asn Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly 
    3050                 3055                 3060             


Asp Ser  Val Ala Val Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu 
    3065                 3070                 3075             


Ala Leu  His Ala Ile Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu 
    3080                 3085                 3090             


Asp Thr  Gly Tyr Pro Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp 
    3095                 3100                 3105             


Ala Arg  Pro Ser Leu Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg 
    3110                 3115                 3120             


Phe Ser  Asp Val Pro Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro 
    3125                 3130                 3135             


Leu Thr  Pro Gln Gly Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His 
    3140                 3145                 3150             


His Thr  Ala Tyr Ile Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro 
    3155                 3160                 3165             


Lys Gly  Val Met Val Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu 
    3170                 3175                 3180             


Trp Met  Gln Asn His Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala 
    3185                 3190                 3195             


Gln Lys  Thr Pro Cys Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe 
    3200                 3205                 3210             


Trp Pro  Phe Ile Ala Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu 
    3215                 3220                 3225             


Ala His  Arg Asp Pro Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr 
    3230                 3235                 3240             


Gly Val  Thr Thr Thr His Phe  Val Pro Ser Met Leu  Ala Ala Phe 
    3245                 3250                 3255             


Val Ala  Ser Leu Thr Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr 
    3260                 3265                 3270             


Leu Lys  Gln Val Phe Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu 
    3275                 3280                 3285             


Cys Arg  Glu Trp Gln Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu 
    3290                 3295                 3300             


Tyr Gly  Pro Thr Glu Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala 
    3305                 3310                 3315             


Phe Gly  Glu Glu Leu Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile 
    3320                 3325                 3330             


Gly Tyr  Pro Val Trp Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met 
    3335                 3340                 3345             


Met His  Pro Val Pro Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr 
    3350                 3355                 3360             


Gly Ile  Gln Leu Ala Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr 
    3365                 3370                 3375             


Ala Ser  Arg Phe Ile Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met 
    3380                 3385                 3390             


Tyr Arg  Thr Gly Asp Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val 
    3395                 3400                 3405             


Glu Tyr  Leu Gly Arg Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln 
    3410                 3415                 3420             


Arg Ile  Glu Leu Gly Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro 
    3425                 3430                 3435             


Asp Val  Glu Gln Ala Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp 
    3440                 3445                 3450             


Ile Pro  Gly Asn Lys His Leu  Val Ala Tyr Ile Val  Pro Gln Glu 
    3455                 3460                 3465             


Glu Gln  Thr Cys Thr Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser 
    3470                 3475                 3480             


Phe Val  Arg Ser Phe Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val 
    3485                 3490                 3495             


Pro Ser  Ala Ile Val Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn 
    3500                 3505                 3510             


Gly Lys  Leu Asp Arg Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser 
    3515                 3520                 3525             


Gln Leu  Glu Thr Ile Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly 
    3530                 3535                 3540             


Cys Asp  Val Gln Asp Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly 
    3545                 3550                 3555             


His Ser  Leu Leu Ala Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln 
    3560                 3565                 3570             


Val Ala  Arg Gln Val Thr Pro  Gly Gln Val Met Val  Ala Ser Thr 
    3575                 3580                 3585             


Val Ala  Lys Leu Ala Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr 
    3590                 3595                 3600             


Val Ala  Pro Arg Asn Pro Ile  Thr Ser Gly Glu Asp  Asn Pro Ile 
    3605                 3610                 3615             


Pro Leu  Cys Gln Gly Asp Gly  Glu Glu Met Ser Thr  Trp Leu Arg 
    3620                 3625                 3630             


Arg Phe  Gly Pro Pro Val Glu  His Arg Ala Arg Leu  Val Cys Phe 
    3635                 3640                 3645             


Pro His  Ala Gly Ala Ala Ala  Asp Ser Tyr Leu Asp  Leu Ala Arg 
    3650                 3655                 3660             


Ala Leu  Ala Pro Glu Ile Asp  Val His Ala Val Gln  Tyr Pro Gly 
    3665                 3670                 3675             


Arg Gln  Asp Arg Arg Asp Glu  Glu Pro Leu Gly Thr  Ala Gly Glu 
    3680                 3685                 3690             


Ile Ala  Asp Glu Val Ala Ala  Val Leu Arg Ala Ser  Gly Gly Asp 
    3695                 3700                 3705             


Gly Pro  Phe Ala Leu Phe Gly  His Ser Met Gly Ala  Leu Ile Ala 
    3710                 3715                 3720             


Tyr Glu  Thr Ala Arg Arg Leu  Glu Arg Glu Pro Gly  Gly Gly Pro 
    3725                 3730                 3735             


Leu Arg  Leu Phe Val Ser Gly  Gln Thr Ala Pro Arg  Val His Glu 
    3740                 3745                 3750             


Arg Arg  Thr Asp Leu Pro Gly  Asp Asp Gly Leu Val  Asp Glu Leu 
    3755                 3760                 3765             


Arg Arg  Leu Gly Thr Ser Glu  Ala Ala Leu Ala Asp  Glu Ala Leu 
    3770                 3775                 3780             


Leu Ala  Met Ser Leu Pro Val  Leu Arg Ala Asp Tyr  Arg Val Leu 
    3785                 3790                 3795             


Arg Ser  Tyr Ala Trp Ala Asp  Gly Pro Pro Leu Arg  Ala Gly Ile 
    3800                 3805                 3810             


Thr Ala  Leu Cys Gly Asp Ala  Asp Pro Leu Thr Ala  Thr Gly Asp 
    3815                 3820                 3825             


Ala Glu  Arg Trp Leu Gln His  Ser Val Ile Pro Gly  Arg Thr Arg 
    3830                 3835                 3840             


Thr Phe  Pro Gly Gly His Phe  Tyr Leu Gly Glu Gln  Val Thr Glu 
    3845                 3850                 3855             


Val Ala  Gly Ala Val Arg Arg  Asp Leu Leu Arg Ala  Gly Leu Ala 
    3860                 3865                 3870             


Gly 
    


<210>  61
<211>  3989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSC

<400>  61

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    1055                 1060                 1065             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    1070                 1075                 1080             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    1085                 1090                 1095             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    1100                 1105                 1110             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    1115                 1120                 1125             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    1130                 1135                 1140             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    1145                 1150                 1155             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    1160                 1165                 1170             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    1175                 1180                 1185             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    1190                 1195                 1200             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    1205                 1210                 1215             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    1220                 1225                 1230             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    1235                 1240                 1245             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    1250                 1255                 1260             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    1265                 1270                 1275             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    1280                 1285                 1290             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    1295                 1300                 1305             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    1310                 1315                 1320             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    1325                 1330                 1335             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    1340                 1345                 1350             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    1355                 1360                 1365             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    1370                 1375                 1380             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    1385                 1390                 1395             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    1400                 1405                 1410             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    1415                 1420                 1425             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    1430                 1435                 1440             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    1445                 1450                 1455             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    1460                 1465                 1470             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    1475                 1480                 1485             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    1490                 1495                 1500             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    1505                 1510                 1515             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    1520                 1525                 1530             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    1535                 1540                 1545             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    1550                 1555                 1560             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    1565                 1570                 1575             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    1580                 1585                 1590             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    1595                 1600                 1605             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    1610                 1615                 1620             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    1625                 1630                 1635             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    1640                 1645                 1650             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    1655                 1660                 1665             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    1670                 1675                 1680             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    1685                 1690                 1695             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    1700                 1705                 1710             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    1715                 1720                 1725             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    1730                 1735                 1740             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    1745                 1750                 1755             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    1760                 1765                 1770             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    1775                 1780                 1785             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    1790                 1795                 1800             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    1805                 1810                 1815             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    1820                 1825                 1830             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    1835                 1840                 1845             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    1850                 1855                 1860             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    1865                 1870                 1875             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    1880                 1885                 1890             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    1895                 1900                 1905             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    1910                 1915                 1920             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    1925                 1930                 1935             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    1940                 1945                 1950             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    1955                 1960                 1965             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    1970                 1975                 1980             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    1985                 1990                 1995             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    2000                 2005                 2010             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    2015                 2020                 2025             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    2030                 2035                 2040             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    2045                 2050                 2055             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    2060                 2065                 2070             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    2075                 2080                 2085             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    2090                 2095                 2100             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    2105                 2110                 2115             


Pro Ile  Leu Pro Val Glu Gln  Pro Phe Val His Ser  Pro Glu Glu 
    2120                 2125                 2130             


Arg Tyr  Arg Pro Phe Ala Leu  Thr Asp Val Gln Gln  Ala Tyr Leu 
    2135                 2140                 2145             


Val Gly  Arg Gln Pro Gly Phe  Ala Leu Gly Gly Val  Gly Ser His 
    2150                 2155                 2160             


Phe Phe  Val Glu Phe Glu Ile  Ala Asp Leu Asp Ile  His Arg Leu 
    2165                 2170                 2175             


Glu Lys  Val Trp Asn Arg Leu  Ile Ala Arg His Asp  Met Leu Arg 
    2180                 2185                 2190             


Ala Val  Val Arg Asp Gly Gln  Gln Arg Val Leu Glu  Gln Thr Pro 
    2195                 2200                 2205             


Pro Trp  Val Ile Pro Ala His  Ile Leu His Ser Pro  Glu Glu Ala 
    2210                 2215                 2220             


Leu Gln  Val Arg Asp Arg Leu  Ala His Gln Val Leu  Asn Pro Glu 
    2225                 2230                 2235             


Val Trp  Pro Val Phe Asp Leu  Gln Val Gly Phe Val  Asp Gly Met 
    2240                 2245                 2250             


Pro Ala  Arg Leu Trp Leu Cys  Leu Asp Asn Leu Leu  Leu Asp Gly 
    2255                 2260                 2265             


Leu Ser  Met Gln Ile Leu Leu  Ser Glu Leu Glu His  Gly Tyr Arg 
    2270                 2275                 2280             


Tyr Pro  Gln Gln Leu Pro Pro  Pro Leu Pro Ile Thr  Phe Arg Asp 
    2285                 2290                 2295             


Tyr Leu  Gln Gln Pro Ala Leu  Arg Thr Pro Asn Pro  Asp Ser Leu 
    2300                 2305                 2310             


Ala Trp  Trp Gln Thr Gln Leu  Asp Asp Ile Pro Pro  Ala Pro Ala 
    2315                 2320                 2325             


Leu Pro  Leu Arg Cys Leu Pro  Gln Asp Val Glu Thr  Pro Arg Phe 
    2330                 2335                 2340             


Ala Arg  Leu Tyr Gly Ala Met  Asp Ser Ala Arg Trp  Arg Arg Leu 
    2345                 2350                 2355             


Lys Gln  Arg Ala Ala Asp Ala  His Leu Thr Pro Ser  Ala Val Leu 
    2360                 2365                 2370             


Leu Ser  Val Trp Ser Thr Val  Leu Ala Ala Trp Ser  Ala Gln Pro 
    2375                 2380                 2385             


Asp Phe  Thr Leu Asn Leu Thr  Leu Phe Asp Arg Arg  Pro Leu His 
    2390                 2395                 2400             


Pro Gln  Ile Asn Gln Ile Leu  Gly Asp Phe Thr Ser  Leu Met Leu 
    2405                 2410                 2415             


Leu Ser  Trp His Pro Gly Glu  Ser Trp Leu Gln Ser  Ala Arg Leu 
    2420                 2425                 2430             


Leu Gln  Gln Arg Leu Ser Glu  Ser Leu Asn His Arg  Asp Val Ser 
    2435                 2440                 2445             


Ala Ile  Arg Val Met Arg Gln  Leu Ala Arg Arg Gln  Asn Val Pro 
    2450                 2455                 2460             


Ala Val  Pro Met Pro Val Val  Phe Thr Ser Ala Leu  Gly Phe Glu 
    2465                 2470                 2475             


Gln Asp  Asn Phe Leu Ala Arg  Arg Asn Leu Leu Lys  Pro Val Trp 
    2480                 2485                 2490             


Gly Ile  Ser Gln Thr Pro Gln  Val Trp Leu Asp His  Gln Val Tyr 
    2495                 2500                 2505             


Glu Ser  Glu Gly Glu Leu Arg  Phe Asn Trp Asp Phe  Val Ala Ala 
    2510                 2515                 2520             


Leu Phe  Pro Asp Gly Gln Val  Glu Arg Gln Phe Ala  Gln Tyr Cys 
    2525                 2530                 2535             


Ala Leu  Leu Asn Arg Met Ala  Glu Asp Asp Ser Ser  Trp Gln Leu 
    2540                 2545                 2550             


Pro Leu  Ala Asp Leu Val Pro  Pro Leu Lys Val Thr  Glu Arg Arg 
    2555                 2560                 2565             


Ala Arg  Arg Leu Arg Pro Glu  Arg Ala Gln Pro Arg  Ile Ala Ala 
    2570                 2575                 2580             


Asp Lys  Ser Ser Val Ser Leu  Ile Cys Asp Thr Phe  Arg Glu Val 
    2585                 2590                 2595             


Val Gly  Glu Pro Val Ala Pro  Ala Glu Asn Phe Phe  Glu Ala Gly 
    2600                 2605                 2610             


Ala Thr  Ser Leu Asn Leu Val  Gln Leu His Val Leu  Leu Gln Arg 
    2615                 2620                 2625             


His Glu  Phe Ala Thr Leu Thr  Leu Leu Asp Leu Phe  Thr His Pro 
    2630                 2635                 2640             


Ser Pro  Val Ala Leu Ala Asn  Tyr Leu Ala Gly Val  Ala Leu Glu 
    2645                 2650                 2655             


Glu Lys  Thr Lys Arg Val Arg  Pro Val Arg Arg Arg  Gln Arg Arg 
    2660                 2665                 2670             


Ile Gly  Glu Pro Phe Pro Leu  Ala Pro Met Gln His  Ala Met Trp 
    2675                 2680                 2685             


Val Gly  Arg His Asp His Gln  Gln Leu Gly Gly Val  Ala Gly His 
    2690                 2695                 2700             


Leu Tyr  Val Glu Phe Asp Gly  Ala Arg Val Asp Pro  Asp Arg Leu 
    2705                 2710                 2715             


Arg Ala  Ala Ala Thr Arg Leu  Ala Leu Arg His Pro  Met Leu Arg 
    2720                 2725                 2730             


Val Gln  Phe Leu Pro Asp Gly  Thr Gln Arg Ile Pro  Pro Ala Ala 
    2735                 2740                 2745             


Gly Ser  Arg Asp Phe Pro Ile  Ser Val Ala Asp Leu  Arg His Val 
    2750                 2755                 2760             


Ala Pro  Asp Val Val Asp Gln  Arg Leu Ala Gly Ile  Arg Asp Ala 
    2765                 2770                 2775             


Lys Ser  His Gln Gln Leu Asp  Gly Ala Val Phe Glu  Leu Ala Leu 
    2780                 2785                 2790             


Thr Leu  Leu Pro Gly Glu Arg  Thr Arg Leu His Val  Asp Leu Asp 
    2795                 2800                 2805             


Met Gln  Ala Ala Asp Ala Met  Ser Tyr Arg Ile Leu  Leu Ala Asp 
    2810                 2815                 2820             


Leu Ala  Ala Leu Tyr Asp Gly  Arg Glu Pro Pro Ala  Leu Gly Tyr 
    2825                 2830                 2835             


Thr Tyr  Arg Glu Tyr Arg Gln  Ala Ile Glu Ala Glu  Glu Thr Leu 
    2840                 2845                 2850             


Pro Gln  Pro Val Arg Asp Ala  Asp Arg Asp Trp Trp  Ala Gln Arg 
    2855                 2860                 2865             


Ile Pro  Gln Leu Pro Asp Pro  Pro Ala Leu Pro Thr  Arg Ala Gly 
    2870                 2875                 2880             


Gly Glu  Arg Asp Arg Arg Arg  Ser Thr Arg Arg Trp  His Trp Leu 
    2885                 2890                 2895             


Asp Pro  Gln Thr Arg Asp Ala  Leu Phe Ala Arg Ala  Arg Ala Arg 
    2900                 2905                 2910             


Gly Ile  Thr Pro Ala Met Thr  Leu Ala Ala Ala Phe  Ala Asn Val 
    2915                 2920                 2925             


Leu Ala  Arg Trp Ser Ala Ser  Ser Arg Phe Leu Leu  Asn Leu Pro 
    2930                 2935                 2940             


Leu Phe  Ser Arg Gln Ala Leu  His Pro Asp Val Asp  Leu Leu Val 
    2945                 2950                 2955             


Gly Asp  Phe Thr Ser Ser Leu  Leu Leu Asp Val Asp  Leu Gly Asp 
    2960                 2965                 2970             


Thr Val  Ser Asn Leu Ala Arg  Lys Asn Gln Leu Thr  Phe Thr Glu 
    2975                 2980                 2985             


Asp Trp  Glu His Arg His Trp  Ser Gly Val Glu Leu  Leu Arg Glu 
    2990                 2995                 3000             


Leu Lys  Arg Gln Gln Arg Tyr  Pro His Gly Ala Pro  Val Val Phe 
    3005                 3010                 3015             


Thr Ser  Asn Leu Gly Arg Ser  Leu Tyr Ser Ser Arg  Ala Glu Ser 
    3020                 3025                 3030             


Pro Leu  Gly Glu Pro Glu Trp  Gly Ile Ser Gln Thr  Pro Gln Val 
    3035                 3040                 3045             


Trp Ile  Asp His Leu Ala Phe  Glu His His Gly Glu  Val Trp Leu 
    3050                 3055                 3060             


Gln Trp  Asp Ser Asn Asp Ala  Leu Phe Pro Pro Ala  Leu Val Glu 
    3065                 3070                 3075             


Thr Leu  Phe Asp Ala Tyr Cys  Gln Leu Ile Asn Gln  Leu Cys Asp 
    3080                 3085                 3090             


Asp Glu  Ser Ala Trp Gln Lys  Pro Phe Ala Asp Met  Met Pro Ala 
    3095                 3100                 3105             


Ser Gln  Arg Ala Ile Arg Glu  Arg Val Asn Ala Thr  Gly Ala Pro 
    3110                 3115                 3120             


Ile Pro  Glu Gly Leu Leu His  Glu Gly Ile Phe Arg  Ile Ala Leu 
    3125                 3130                 3135             


Gln Gln  Pro Gln Ala Leu Ala  Val Thr Asp Met Arg  Tyr Gln Trp 
    3140                 3145                 3150             


Asn Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    3155                 3160                 3165             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    3170                 3175                 3180             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    3185                 3190                 3195             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    3200                 3205                 3210             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    3215                 3220                 3225             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    3230                 3235                 3240             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    3245                 3250                 3255             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    3260                 3265                 3270             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    3275                 3280                 3285             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    3290                 3295                 3300             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    3305                 3310                 3315             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    3320                 3325                 3330             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    3335                 3340                 3345             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    3350                 3355                 3360             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    3365                 3370                 3375             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    3380                 3385                 3390             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    3395                 3400                 3405             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    3410                 3415                 3420             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    3425                 3430                 3435             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    3440                 3445                 3450             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    3455                 3460                 3465             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    3470                 3475                 3480             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    3485                 3490                 3495             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    3500                 3505                 3510             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    3515                 3520                 3525             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    3530                 3535                 3540             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    3545                 3550                 3555             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    3560                 3565                 3570             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    3575                 3580                 3585             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    3590                 3595                 3600             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    3605                 3610                 3615             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    3620                 3625                 3630             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Leu Asp Lys 
    3635                 3640                 3645             


Tyr Val  Ala Pro Arg Asn Pro  Ile Glu Thr Ile Ile  Ala Ala Ala 
    3650                 3655                 3660             


Phe Ser  Ser Leu Leu Gly Cys  Asp Val Gln Asp Ala  Asp Ala Asp 
    3665                 3670                 3675             


Phe Phe  Ala Leu Gly Gly His  Ser Leu Leu Ala Met  Lys Leu Ala 
    3680                 3685                 3690             


Ala Gln  Leu Ser Arg Gln Val  Ala Arg Gln Val Thr  Pro Gly Gln 
    3695                 3700                 3705             


Val Met  Val Ala Ser Thr Val  Ala Lys Leu Ala Thr  Ile Ile Asp 
    3710                 3715                 3720             


Ala Glu  Thr Ser Gly Glu Asp  Asn Pro Ile Pro Leu  Cys Gln Gly 
    3725                 3730                 3735             


Asp Gly  Glu Glu Met Ser Thr  Trp Leu Arg Arg Phe  Gly Pro Pro 
    3740                 3745                 3750             


Val Glu  His Arg Ala Arg Leu  Val Cys Phe Pro His  Ala Gly Ala 
    3755                 3760                 3765             


Ala Ala  Asp Ser Tyr Leu Asp  Leu Ala Arg Ala Leu  Ala Pro Glu 
    3770                 3775                 3780             


Ile Asp  Val His Ala Val Gln  Tyr Pro Gly Arg Gln  Asp Arg Arg 
    3785                 3790                 3795             


Asp Glu  Glu Pro Leu Gly Thr  Ala Gly Glu Ile Ala  Asp Glu Val 
    3800                 3805                 3810             


Ala Ala  Val Leu Arg Ala Ser  Gly Gly Asp Gly Pro  Phe Ala Leu 
    3815                 3820                 3825             


Phe Gly  His Ser Met Gly Ala  Leu Ile Ala Tyr Glu  Thr Ala Arg 
    3830                 3835                 3840             


Arg Leu  Glu Arg Glu Pro Gly  Gly Gly Pro Leu Arg  Leu Phe Val 
    3845                 3850                 3855             


Ser Gly  Gln Thr Ala Pro Arg  Val His Glu Arg Arg  Thr Asp Leu 
    3860                 3865                 3870             


Pro Gly  Asp Asp Gly Leu Val  Asp Glu Leu Arg Arg  Leu Gly Thr 
    3875                 3880                 3885             


Ser Glu  Ala Ala Leu Ala Asp  Glu Ala Leu Leu Ala  Met Ser Leu 
    3890                 3895                 3900             


Pro Val  Leu Arg Ala Asp Tyr  Arg Val Leu Arg Ser  Tyr Ala Trp 
    3905                 3910                 3915             


Ala Asp  Gly Pro Pro Leu Arg  Ala Gly Ile Thr Ala  Leu Cys Gly 
    3920                 3925                 3930             


Asp Ala  Asp Pro Leu Thr Ala  Thr Gly Asp Ala Glu  Arg Trp Leu 
    3935                 3940                 3945             


Gln His  Ser Val Ile Pro Gly  Arg Thr Arg Thr Phe  Pro Gly Gly 
    3950                 3955                 3960             


His Phe  Tyr Leu Gly Glu Gln  Val Thr Glu Val Ala  Gly Ala Val 
    3965                 3970                 3975             


Arg Arg  Asp Leu Leu Arg Ala  Gly Leu Ala Gly 
    3980                 3985                 


<210>  62
<211>  4430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSH

<400>  62

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    1055                 1060                 1065             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    1070                 1075                 1080             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    1085                 1090                 1095             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    1100                 1105                 1110             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    1115                 1120                 1125             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    1130                 1135                 1140             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    1145                 1150                 1155             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    1160                 1165                 1170             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    1175                 1180                 1185             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    1190                 1195                 1200             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    1205                 1210                 1215             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    1220                 1225                 1230             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    1235                 1240                 1245             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    1250                 1255                 1260             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    1265                 1270                 1275             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    1280                 1285                 1290             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    1295                 1300                 1305             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    1310                 1315                 1320             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    1325                 1330                 1335             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    1340                 1345                 1350             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    1355                 1360                 1365             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    1370                 1375                 1380             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    1385                 1390                 1395             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    1400                 1405                 1410             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    1415                 1420                 1425             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    1430                 1435                 1440             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    1445                 1450                 1455             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    1460                 1465                 1470             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    1475                 1480                 1485             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    1490                 1495                 1500             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    1505                 1510                 1515             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    1520                 1525                 1530             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    1535                 1540                 1545             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    1550                 1555                 1560             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    1565                 1570                 1575             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    1580                 1585                 1590             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    1595                 1600                 1605             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    1610                 1615                 1620             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    1625                 1630                 1635             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    1640                 1645                 1650             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    1655                 1660                 1665             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    1670                 1675                 1680             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    1685                 1690                 1695             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    1700                 1705                 1710             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    1715                 1720                 1725             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    1730                 1735                 1740             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    1745                 1750                 1755             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    1760                 1765                 1770             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    1775                 1780                 1785             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    1790                 1795                 1800             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    1805                 1810                 1815             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    1820                 1825                 1830             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    1835                 1840                 1845             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    1850                 1855                 1860             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    1865                 1870                 1875             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    1880                 1885                 1890             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    1895                 1900                 1905             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    1910                 1915                 1920             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    1925                 1930                 1935             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    1940                 1945                 1950             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    1955                 1960                 1965             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    1970                 1975                 1980             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    1985                 1990                 1995             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    2000                 2005                 2010             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    2015                 2020                 2025             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    2030                 2035                 2040             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    2045                 2050                 2055             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    2060                 2065                 2070             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    2075                 2080                 2085             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    2090                 2095                 2100             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    2105                 2110                 2115             


Pro Ile  Pro Gly Ile Gly Ala  Leu Val Pro Ala Pro  Val Val Ile 
    2120                 2125                 2130             


Ala Ala  Gly Arg Thr Glu Glu  Pro Ile Ala Ile Val  Ser Met Ala 
    2135                 2140                 2145             


Cys Arg  Leu Pro Gly Gly Val  Asn Thr Pro Gln Arg  Leu Trp Glu 
    2150                 2155                 2160             


Leu Leu  Arg Glu Gly Gly Glu  Thr Leu Ser Gly Phe  Pro Thr Asp 
    2165                 2170                 2175             


Arg Gly  Trp Asp Leu Ala Arg  Leu His His Pro Asp  Pro Asp Asn 
    2180                 2185                 2190             


Pro Gly  Thr Ser Tyr Val Asp  Lys Gly Gly Phe Leu  Asp Asp Ala 
    2195                 2200                 2205             


Ala Gly  Phe Asp Ala Glu Phe  Phe Gly Val Ser Pro  Arg Glu Ala 
    2210                 2215                 2220             


Ala Ala  Met Asp Pro Gln Gln  Arg Leu Leu Leu Glu  Thr Ser Trp 
    2225                 2230                 2235             


Glu Leu  Val Glu Asn Ala Gly  Ile Asp Pro His Ser  Leu Arg Gly 
    2240                 2245                 2250             


Thr Ala  Thr Gly Val Phe Leu  Gly Val Ala Lys Phe  Gly Tyr Gly 
    2255                 2260                 2265             


Glu Asp  Thr Ala Ala Ala Glu  Asp Val Glu Gly Tyr  Ser Val Thr 
    2270                 2275                 2280             


Gly Val  Ala Pro Ala Val Ala  Ser Gly Arg Ile Ser  Tyr Thr Met 
    2285                 2290                 2295             


Gly Leu  Glu Gly Pro Ser Ile  Ser Val Asp Thr Ala  Cys Ser Ser 
    2300                 2305                 2310             


Ser Leu  Val Ala Leu His Leu  Ala Val Glu Ser Leu  Arg Lys Gly 
    2315                 2320                 2325             


Glu Ser  Ser Met Ala Val Val  Gly Gly Ala Ala Val  Met Ala Thr 
    2330                 2335                 2340             


Pro Gly  Val Phe Val Asp Phe  Ser Arg Gln Arg Ala  Leu Ala Ala 
    2345                 2350                 2355             


Asp Gly  Arg Ser Lys Ala Phe  Gly Ala Gly Ala Asp  Gly Phe Gly 
    2360                 2365                 2370             


Phe Ser  Glu Gly Val Thr Leu  Val Leu Leu Glu Arg  Leu Ser Glu 
    2375                 2380                 2385             


Ala Arg  Arg Asn Gly His Glu  Val Leu Ala Val Val  Arg Gly Ser 
    2390                 2395                 2400             


Ala Leu  Asn Gln Asp Gly Ala  Ser Asn Gly Leu Ser  Ala Pro Ser 
    2405                 2410                 2415             


Gly Pro  Ala Gln Arg Arg Val  Ile Arg Gln Ala Leu  Glu Ser Cys 
    2420                 2425                 2430             


Gly Leu  Glu Pro Gly Asp Val  Asp Ala Val Glu Ala  His Gly Thr 
    2435                 2440                 2445             


Gly Thr  Ala Leu Gly Asp Pro  Ile Glu Ala Asn Ala  Leu Leu Asp 
    2450                 2455                 2460             


Thr Tyr  Gly Arg Asp Arg Asp  Ala Asp Arg Pro Leu  Trp Leu Gly 
    2465                 2470                 2475             


Ser Val  Lys Ser Asn Ile Gly  His Thr Gln Ala Ala  Ala Gly Val 
    2480                 2485                 2490             


Thr Gly  Leu Leu Lys Val Val  Leu Ala Leu Arg Asn  Gly Glu Leu 
    2495                 2500                 2505             


Pro Ala  Thr Leu His Val Glu  Glu Pro Thr Pro His  Val Asp Trp 
    2510                 2515                 2520             


Ser Ser  Gly Gly Val Ala Leu  Leu Ala Gly Asn Gln  Pro Trp Arg 
    2525                 2530                 2535             


Arg Gly  Glu Arg Thr Arg Arg  Ala Ala Val Ser Ala  Phe Gly Ile 
    2540                 2545                 2550             


Ser Gly  Thr Asn Ala His Val  Ile Val Glu Glu Ala  Pro Gln Glu 
    2555                 2560                 2565             


Val Arg  Pro Ala Pro Gly Gln  Gly Leu Ser Pro Ala  Val Ser Thr 
    2570                 2575                 2580             


Leu Val  Val Ala Gly Lys Thr  Met Gln Arg Val Ser  Ala Thr Ala 
    2585                 2590                 2595             


Gly Met  Leu Ala Asp Trp Met  Glu Gly Pro Gly Ala  Asp Val Ala 
    2600                 2605                 2610             


Leu Ala  Asp Val Ala His Thr  Leu Asn His His Arg  Ser Arg Gln 
    2615                 2620                 2625             


Pro Lys  Phe Gly Thr Val Val  Ala Arg Asp Arg Thr  Gln Ala Ile 
    2630                 2635                 2640             


Ala Gly  Leu Arg Ala Leu Ala  Ala Gly Gln His Ala  Pro Gly Val 
    2645                 2650                 2655             


Val Asn  Pro Ala Glu Gly Ser  Pro Gly Pro Gly Thr  Val Phe Val 
    2660                 2665                 2670             


Phe Pro  Gly Gln Gly Ser Gln  Arg Ala Gly Met Gly  Glu Glu Leu 
    2675                 2680                 2685             


Ala Ala  Ala Phe Pro Val Phe  Ala Arg Ile His Gln  Gln Val Trp 
    2690                 2695                 2700             


Asp Leu  Leu Asp Val Pro Asp  Leu Asp Val Asn Glu  Thr Gly Tyr 
    2705                 2710                 2715             


Ala Gln  Pro Ala Leu Phe Ala  Leu Gln Val Ala Leu  Phe Gly Leu 
    2720                 2725                 2730             


Leu Glu  Ser Trp Gly Val Arg  Pro Asp Ala Val Val  Gly His Ser 
    2735                 2740                 2745             


Val Gly  Glu Leu Ala Ala Gly  Tyr Val Ser Gly Leu  Trp Ser Leu 
    2750                 2755                 2760             


Glu Asp  Ala Cys Thr Leu Val  Ser Ala Arg Ala Arg  Leu Met Gln 
    2765                 2770                 2775             


Ala Leu  Pro Ala Gly Gly Val  Met Ala Ala Val Pro  Val Ser Glu 
    2780                 2785                 2790             


Asp Glu  Ala Arg Ala Val Leu  Gly Glu Gly Val Glu  Ile Ala Ala 
    2795                 2800                 2805             


Val Asn  Gly Pro Ser Ser Val  Val Leu Ser Gly Asp  Glu Ala Ala 
    2810                 2815                 2820             


Val Leu  Gln Ala Ala Glu Gly  Leu Gly Lys Trp Thr  Arg Leu Pro 
    2825                 2830                 2835             


Thr Ser  His Ala Phe His Ser  Ala Arg Met Glu Pro  Met Leu Glu 
    2840                 2845                 2850             


Glu Phe  Arg Ala Val Ala Glu  Gly Leu Thr Tyr Arg  Thr Pro Gln 
    2855                 2860                 2865             


Val Ala  Met Ala Ala Gly Asp  Gln Val Met Thr Ala  Glu Tyr Trp 
    2870                 2875                 2880             


Val Arg  Gln Val Arg Asp Thr  Val Arg Phe Gly Glu  Gln Val Ala 
    2885                 2890                 2895             


Ser Phe  Glu Asp Ala Val Phe  Val Glu Leu Gly Ala  Asp Arg Ser 
    2900                 2905                 2910             


Leu Ala  Arg Leu Val Asp Gly  Ile Ala Met Leu His  Gly Asp His 
    2915                 2920                 2925             


Glu Ala  Gln Ala Gly Met Arg  Arg Glu Gln Pro Leu  Pro Leu Gly 
    2930                 2935                 2940             


Leu Arg  Arg Leu Leu Thr Asp  Leu His Asn Ala Gly  Ala Ala Val 
    2945                 2950                 2955             


Asp Phe  Ser Val Leu Cys Pro  Gln Gly Arg Leu Val  Asp Ala Pro 
    2960                 2965                 2970             


Leu Pro  Ala Trp Ser His Arg  Phe Leu Phe Tyr Asp  Arg Glu Gly 
    2975                 2980                 2985             


Val Asp  Asn Arg Ser Pro Gly  Gly Ser Thr Val Ala  Val His Pro 
    2990                 2995                 3000             


Leu Leu  Leu Ala Ala Val Asp  Val Pro Gly His Gly  Gly Ala Val 
    3005                 3010                 3015             


Phe Thr  Gly Arg Leu Ser Thr  Asp Glu Gln Pro Trp  Leu Ala Glu 
    3020                 3025                 3030             


His Val  Val Gly Gly Arg Thr  Leu Val Pro Gly Ser  Val Leu Val 
    3035                 3040                 3045             


Asp Leu  Ala Leu Ala Ala Gly  Glu Asp Val Gly Leu  Pro Val Leu 
    3050                 3055                 3060             


Glu Glu  Leu Val Leu Gln Arg  Pro Leu Val Leu Ala  Gly Ala Gly 
    3065                 3070                 3075             


Ala Leu  Leu Arg Met Ser Val  Gly Ala Pro Asp Glu  Ser Gly Arg 
    3080                 3085                 3090             


Arg Thr  Ile Asp Val His Ala  Ala Glu Asp Val Ala  Asp Leu Ala 
    3095                 3100                 3105             


Asp Ala  Gln Trp Ser Gln His  Ala Thr Gly Thr Leu  Ala Gln Gly 
    3110                 3115                 3120             


Val Ala  Ala Gly Pro Arg Asp  Thr Glu Gln Trp Pro  Pro Glu Asp 
    3125                 3130                 3135             


Ala Val  Arg Ile Pro Leu Asp  Asp His Tyr Asp Gly  Leu Ala Glu 
    3140                 3145                 3150             


Gln Gly  Tyr Glu Tyr Gly Pro  Ser Phe Gln Ala Leu  Val Ala Tyr 
    3155                 3160                 3165             


Val Ala  Glu Asp Ala Thr Ala  Thr Met Leu Ala Glu  Val Ala Leu 
    3170                 3175                 3180             


Pro Gly  Ser Ile Arg Ser Gln  Gln Gly Leu Tyr Ala  Ile His Pro 
    3185                 3190                 3195             


Ala Leu  Leu Asp Ala Cys Phe  Gln Ser Val Gly Ala  His Pro Asp 
    3200                 3205                 3210             


Ser Gln  Ser Val Gly Ser Gly  Leu Leu Val Pro Leu  Gly Val Arg 
    3215                 3220                 3225             


Arg Val  Arg Ala Tyr Ala Pro  Val Arg Thr Ala Arg  Tyr Cys Tyr 
    3230                 3235                 3240             


Thr Arg  Val Thr Lys Val Glu  Leu Ala Gly Val Glu  Ala Asp Ile 
    3245                 3250                 3255             


Asp Val  Leu Asp Ala His Gly  Thr Val Leu Leu Ala  Val Cys Gly 
    3260                 3265                 3270             


Leu Arg  Ile Gly Thr Gly Val  Ser Glu Arg Asp Lys  His Asn Arg 
    3275                 3280                 3285             


Val Leu  Asn Glu Arg Leu Leu  Thr Ile Glu Trp His  Gln Arg Glu 
    3290                 3295                 3300             


Leu Pro  Glu Met Asp Pro Ser  Gly Ala Gly Lys Trp  Leu Leu Ile 
    3305                 3310                 3315             


Ser Asp  Cys Ala Ala Ser Asp  Val Thr Ala Thr Arg  Leu Ala Asp 
    3320                 3325                 3330             


Ala Phe  Arg Glu His Ser Ala  Ala Cys Thr Thr Met  Arg Trp Pro 
    3335                 3340                 3345             


Leu His  Asp Asp Gln Leu Ala  Ala Ala Asp Gln Leu  Arg Asp Gln 
    3350                 3355                 3360             


Val Gly  Ser Asp Glu Phe Ser  Gly Val Val Val Leu  Thr Gly Pro 
    3365                 3370                 3375             


Asn Thr  Gly Thr Pro His Gln  Gly Ser Ala Asp Arg  Gly Ala Glu 
    3380                 3385                 3390             


Tyr Val  Arg Arg Leu Val Gly  Ile Ala Arg Glu Leu  Ser Asp Leu 
    3395                 3400                 3405             


Pro Gly  Ala Val Pro Arg Met  Tyr Val Val Thr Arg  Gly Ala Gln 
    3410                 3415                 3420             


Arg Val  Leu Ala Asp Asp Cys  Val Asn Leu Glu Gln  Gly Gly Leu 
    3425                 3430                 3435             


Arg Gly  Leu Leu Arg Thr Ile  Gly Ala Glu His Pro  His Leu Arg 
    3440                 3445                 3450             


Ala Thr  Gln Ile Asp Val Asp  Glu Gln Thr Gly Val  Glu Gln Leu 
    3455                 3460                 3465             


Ala Arg  Gln Leu Leu Ala Thr  Ser Glu Glu Asp Glu  Thr Ala Trp 
    3470                 3475                 3480             


Arg Asp  Asn Glu Trp Tyr Val  Ala Arg Leu Cys Pro  Thr Pro Leu 
    3485                 3490                 3495             


Arg Pro  Gln Glu Arg Arg Thr  Ile Val Ala Asp His  Gln Gln Ser 
    3500                 3505                 3510             


Gly Met  Arg Leu Gln Ile Arg  Thr Pro Gly Ala Ile  Asp Ser Val 
    3515                 3520                 3525             


Ala Phe  Glu Pro Ala Pro Asp  Val Glu Gln Pro Leu  Arg Ala Gly 
    3530                 3535                 3540             


Glu Val  Arg Val Asp Val Arg  Ala Thr Gly Val Asn  Phe Arg Asp 
    3545                 3550                 3555             


Val Leu  Leu Ala Leu Gly Met  Tyr Pro Gln Lys Ala  Asp Met Gly 
    3560                 3565                 3570             


Thr Glu  Ala Ala Gly Val Val  Thr Ala Val Gly Pro  Asp Val Asp 
    3575                 3580                 3585             


Ala Phe  Ala Pro Gly Asp Arg  Val Leu Gly Leu Phe  Gln Gly Ala 
    3590                 3595                 3600             


Phe Ala  Pro Ile Ala Val Thr  Asp His Arg Leu Leu  Ala Arg Val 
    3605                 3610                 3615             


Pro Asp  Gly Trp Ser Asp Ala  Asp Ala Ala Ala Val  Pro Ile Ala 
    3620                 3625                 3630             


Tyr Thr  Thr Ala His Tyr Ala  Leu His Asp Leu Ala  Gly Leu Arg 
    3635                 3640                 3645             


Ala Gly  Gln Ser Val Leu Ile  His Ala Ala Ala Gly  Gly Val Gly 
    3650                 3655                 3660             


Met Ala  Ala Val Ala Leu Ala  Arg Arg Ala Gly Ala  Glu Val Leu 
    3665                 3670                 3675             


Ala Thr  Ala Gly Pro Ala Lys  His Gly Thr Leu Arg  Ala Leu Gly 
    3680                 3685                 3690             


Leu Asp  Asp Glu His Ile Ala  Ser Ser Arg Glu Thr  Gly Phe Ala 
    3695                 3700                 3705             


Arg Lys  Phe Arg Glu Arg Thr  Gly Gly Arg Gly Val  Asp Val Val 
    3710                 3715                 3720             


Leu Asn  Ser Leu Thr Gly Glu  Leu Leu Asp Glu Ser  Ala Asp Leu 
    3725                 3730                 3735             


Leu Ala  Glu Asp Gly Val Phe  Val Glu Met Gly Lys  Thr Asp Leu 
    3740                 3745                 3750             


Arg Asp  Ala Gly Asp Phe Arg  Gly Arg Tyr Ala Pro  Phe Asp Leu 
    3755                 3760                 3765             


Gly Glu  Ala Gly Asp Asp Arg  Leu Gly Glu Ile Leu  Arg Glu Val 
    3770                 3775                 3780             


Val Gly  Leu Leu Gly Ala Gly  Glu Leu Asp Arg Leu  Pro Val Ser 
    3785                 3790                 3795             


Ala Trp  Glu Leu Gly Ile Pro  Gln Thr Gly Lys Ser  Leu Val Thr 
    3800                 3805                 3810             


Leu Pro  Pro Glu Gln Ala Gln  Val Phe Arg Pro Asp  Gly Thr Val 
    3815                 3820                 3825             


Leu Ile  Thr Gly Gly Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg 
    3830                 3835                 3840             


His Leu  Val Thr Glu His Gly  Val Arg His Leu Leu  Leu Val Ser 
    3845                 3850                 3855             


Arg Arg  Gly Ala Asp Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu 
    3860                 3865                 3870             


Ile Glu  Asp Leu Gly Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr 
    3875                 3880                 3885             


Ala Asp  Arg Asp Ala Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg 
    3890                 3895                 3900             


Pro Leu  Thr Gly Val Val His  Ala Ala Gly Val Leu  Ala Asp Gly 
    3905                 3910                 3915             


Leu Val  Thr Ser Ile Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg 
    3920                 3925                 3930             


Ala Lys  Val Asp Ala Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn 
    3935                 3940                 3945             


Thr Gly  Leu Ser Phe Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val 
    3950                 3955                 3960             


Leu Ala  Gly Pro Gly Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser 
    3965                 3970                 3975             


Leu Asn  Ala Leu Ala Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala 
    3980                 3985                 3990             


Lys Ala  Leu Gly Trp Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala 
    3995                 4000                 4005             


Phe Ala  Glu Gln Thr Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala 
    4010                 4015                 4020             


Tyr Ala  Phe Glu Thr Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly 
    4025                 4030                 4035             


Tyr Ala  Pro Val Ile Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln 
    4040                 4045                 4050             


His Ser  Pro Phe Ala Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg 
    4055                 4060                 4065             


Ser Gly  Thr Ser Lys Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg 
    4070                 4075                 4080             


Glu Glu  Trp Pro Asp Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg 
    4085                 4090                 4095             


Ser His  Ala Ala Ala Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu 
    4100                 4105                 4110             


Pro Glu  Arg Lys Ala Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala 
    4115                 4120                 4125             


Ala Val  Glu Leu Arg Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg 
    4130                 4135                 4140             


Leu Pro  Ser Thr Leu Val Phe  Asp His Pro Thr Pro  Leu Ala Val 
    4145                 4150                 4155             


Ala Glu  His Leu Arg Asp Arg  Leu Thr Ser Gly Glu  Asp Asn Pro 
    4160                 4165                 4170             


Ile Pro  Leu Cys Gln Gly Asp  Gly Glu Glu Met Ser  Thr Trp Leu 
    4175                 4180                 4185             


Arg Arg  Phe Gly Pro Pro Val  Glu His Arg Ala Arg  Leu Val Cys 
    4190                 4195                 4200             


Phe Pro  His Ala Gly Ala Ala  Ala Asp Ser Tyr Leu  Asp Leu Ala 
    4205                 4210                 4215             


Arg Ala  Leu Ala Pro Glu Ile  Asp Val His Ala Val  Gln Tyr Pro 
    4220                 4225                 4230             


Gly Arg  Gln Asp Arg Arg Asp  Glu Glu Pro Leu Gly  Thr Ala Gly 
    4235                 4240                 4245             


Glu Ile  Ala Asp Glu Val Ala  Ala Val Leu Arg Ala  Ser Gly Gly 
    4250                 4255                 4260             


Asp Gly  Pro Phe Ala Leu Phe  Gly His Ser Met Gly  Ala Leu Ile 
    4265                 4270                 4275             


Ala Tyr  Glu Thr Ala Arg Arg  Leu Glu Arg Glu Pro  Gly Gly Gly 
    4280                 4285                 4290             


Pro Leu  Arg Leu Phe Val Ser  Gly Gln Thr Ala Pro  Arg Val His 
    4295                 4300                 4305             


Glu Arg  Arg Thr Asp Leu Pro  Gly Asp Asp Gly Leu  Val Asp Glu 
    4310                 4315                 4320             


Leu Arg  Arg Leu Gly Thr Ser  Glu Ala Ala Leu Ala  Asp Glu Ala 
    4325                 4330                 4335             


Leu Leu  Ala Met Ser Leu Pro  Val Leu Arg Ala Asp  Tyr Arg Val 
    4340                 4345                 4350             


Leu Arg  Ser Tyr Ala Trp Ala  Asp Gly Pro Pro Leu  Arg Ala Gly 
    4355                 4360                 4365             


Ile Thr  Ala Leu Cys Gly Asp  Ala Asp Pro Leu Thr  Ala Thr Gly 
    4370                 4375                 4380             


Asp Ala  Glu Arg Trp Leu Gln  His Ser Val Ile Pro  Gly Arg Thr 
    4385                 4390                 4395             


Arg Thr  Phe Pro Gly Gly His  Phe Tyr Leu Gly Glu  Gln Val Thr 
    4400                 4405                 4410             


Glu Val  Ala Gly Ala Val Arg  Arg Asp Leu Leu Arg  Ala Gly Leu 
    4415                 4420                 4425             


Ala Gly  
    4430 


<210>  63
<211>  3879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSO

<400>  63

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    1055                 1060                 1065             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    1070                 1075                 1080             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    1085                 1090                 1095             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    1100                 1105                 1110             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    1115                 1120                 1125             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    1130                 1135                 1140             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    1145                 1150                 1155             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    1160                 1165                 1170             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    1175                 1180                 1185             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    1190                 1195                 1200             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    1205                 1210                 1215             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    1220                 1225                 1230             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    1235                 1240                 1245             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    1250                 1255                 1260             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    1265                 1270                 1275             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    1280                 1285                 1290             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    1295                 1300                 1305             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    1310                 1315                 1320             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    1325                 1330                 1335             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    1340                 1345                 1350             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    1355                 1360                 1365             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    1370                 1375                 1380             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    1385                 1390                 1395             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    1400                 1405                 1410             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    1415                 1420                 1425             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    1430                 1435                 1440             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    1445                 1450                 1455             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    1460                 1465                 1470             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    1475                 1480                 1485             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    1490                 1495                 1500             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    1505                 1510                 1515             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    1520                 1525                 1530             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    1535                 1540                 1545             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    1550                 1555                 1560             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    1565                 1570                 1575             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    1580                 1585                 1590             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    1595                 1600                 1605             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    1610                 1615                 1620             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    1625                 1630                 1635             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    1640                 1645                 1650             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    1655                 1660                 1665             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    1670                 1675                 1680             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    1685                 1690                 1695             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    1700                 1705                 1710             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    1715                 1720                 1725             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    1730                 1735                 1740             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    1745                 1750                 1755             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    1760                 1765                 1770             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    1775                 1780                 1785             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    1790                 1795                 1800             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    1805                 1810                 1815             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    1820                 1825                 1830             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    1835                 1840                 1845             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    1850                 1855                 1860             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    1865                 1870                 1875             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    1880                 1885                 1890             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    1895                 1900                 1905             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    1910                 1915                 1920             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    1925                 1930                 1935             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    1940                 1945                 1950             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    1955                 1960                 1965             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    1970                 1975                 1980             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    1985                 1990                 1995             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    2000                 2005                 2010             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    2015                 2020                 2025             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    2030                 2035                 2040             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    2045                 2050                 2055             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    2060                 2065                 2070             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    2075                 2080                 2085             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    2090                 2095                 2100             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    2105                 2110                 2115             


Pro Ile  Pro Gly Ile Gly Ala  Leu Val Pro Ala Pro  Val Val Ile 
    2120                 2125                 2130             


Ala Ala  Gly Arg Thr Glu Glu  Pro Ile Ala Ile Val  Ser Met Ala 
    2135                 2140                 2145             


Cys Arg  Leu Pro Gly Gly Val  Asn Thr Pro Gln Arg  Leu Trp Glu 
    2150                 2155                 2160             


Leu Leu  Arg Glu Gly Gly Glu  Thr Leu Ser Gly Phe  Pro Thr Asp 
    2165                 2170                 2175             


Arg Gly  Trp Asp Leu Ala Arg  Leu His His Pro Asp  Pro Asp Asn 
    2180                 2185                 2190             


Pro Gly  Thr Ser Tyr Val Asp  Lys Gly Gly Phe Leu  Asp Asp Ala 
    2195                 2200                 2205             


Ala Gly  Phe Asp Ala Glu Phe  Phe Gly Val Ser Pro  Arg Glu Ala 
    2210                 2215                 2220             


Ala Ala  Met Asp Pro Gln Gln  Arg Leu Leu Leu Glu  Thr Ser Trp 
    2225                 2230                 2235             


Glu Leu  Val Glu Asn Ala Gly  Ile Asp Pro His Ser  Leu Arg Gly 
    2240                 2245                 2250             


Thr Ala  Thr Gly Val Phe Leu  Gly Val Ala Lys Phe  Gly Tyr Gly 
    2255                 2260                 2265             


Glu Asp  Thr Ala Ala Ala Glu  Asp Val Glu Gly Tyr  Ser Val Thr 
    2270                 2275                 2280             


Gly Val  Ala Pro Ala Val Ala  Ser Gly Arg Ile Ser  Tyr Thr Met 
    2285                 2290                 2295             


Gly Leu  Glu Gly Pro Ser Ile  Ser Val Asp Thr Ala  Cys Ser Ser 
    2300                 2305                 2310             


Ser Leu  Val Ala Leu His Leu  Ala Val Glu Ser Leu  Arg Lys Gly 
    2315                 2320                 2325             


Glu Ser  Ser Met Ala Val Val  Gly Gly Ala Ala Val  Met Ala Thr 
    2330                 2335                 2340             


Pro Gly  Val Phe Val Asp Phe  Ser Arg Gln Arg Ala  Leu Ala Ala 
    2345                 2350                 2355             


Asp Gly  Arg Ser Lys Ala Phe  Gly Ala Gly Ala Asp  Gly Phe Gly 
    2360                 2365                 2370             


Phe Ser  Glu Gly Val Thr Leu  Val Leu Leu Glu Arg  Leu Ser Glu 
    2375                 2380                 2385             


Ala Arg  Arg Asn Gly His Glu  Val Leu Ala Val Val  Arg Gly Ser 
    2390                 2395                 2400             


Ala Leu  Asn Gln Asp Gly Ala  Ser Asn Gly Leu Ser  Ala Pro Ser 
    2405                 2410                 2415             


Gly Pro  Ala Gln Arg Arg Val  Ile Arg Gln Ala Leu  Glu Ser Cys 
    2420                 2425                 2430             


Gly Leu  Glu Pro Gly Asp Val  Asp Ala Val Glu Ala  His Gly Thr 
    2435                 2440                 2445             


Gly Thr  Ala Leu Gly Asp Pro  Ile Glu Ala Asn Ala  Leu Leu Asp 
    2450                 2455                 2460             


Thr Tyr  Gly Arg Asp Arg Asp  Ala Asp Arg Pro Leu  Trp Leu Gly 
    2465                 2470                 2475             


Ser Val  Lys Ser Asn Ile Gly  His Thr Gln Ala Ala  Ala Gly Val 
    2480                 2485                 2490             


Thr Gly  Leu Leu Lys Val Val  Leu Ala Leu Arg Asn  Gly Glu Leu 
    2495                 2500                 2505             


Pro Ala  Thr Leu His Val Glu  Glu Pro Thr Pro His  Val Asp Trp 
    2510                 2515                 2520             


Ser Ser  Gly Gly Val Ala Leu  Leu Ala Gly Asn Gln  Pro Trp Arg 
    2525                 2530                 2535             


Arg Gly  Glu Arg Thr Arg Arg  Ala Ala Val Ser Ala  Phe Gly Ile 
    2540                 2545                 2550             


Ser Gly  Thr Asn Ala His Val  Ile Val Glu Glu Ala  Pro Gln Glu 
    2555                 2560                 2565             


Val Arg  Pro Ala Pro Gly Gln  Gly Leu Ser Pro Ala  Val Ser Thr 
    2570                 2575                 2580             


Leu Val  Val Ala Gly Lys Thr  Met Gln Arg Val Ser  Ala Thr Ala 
    2585                 2590                 2595             


Gly Met  Leu Ala Asp Trp Met  Glu Gly Pro Gly Ala  Asp Val Ala 
    2600                 2605                 2610             


Leu Ala  Asp Val Ala His Thr  Leu Asn His His Arg  Ser Arg Gln 
    2615                 2620                 2625             


Pro Lys  Phe Gly Thr Val Val  Ala Arg Asp Arg Thr  Gln Ala Ile 
    2630                 2635                 2640             


Ala Gly  Leu Arg Ala Leu Ala  Ala Gly Gln His Ala  Pro Gly Val 
    2645                 2650                 2655             


Val Asn  Pro Ala Glu Gly Ser  Pro Gly Pro Gly Thr  Val Phe Val 
    2660                 2665                 2670             


Phe Pro  Gly Gln Gly Ser Gln  Arg Ala Gly Met Gly  Glu Glu Leu 
    2675                 2680                 2685             


Ala Ala  Ala Phe Pro Val Phe  Ala Arg Ile His Gln  Gln Val Trp 
    2690                 2695                 2700             


Asp Leu  Leu Asp Val Pro Asp  Leu Asp Val Asn Glu  Thr Gly Tyr 
    2705                 2710                 2715             


Ala Gln  Pro Ala Leu Phe Ala  Leu Gln Val Ala Leu  Phe Gly Leu 
    2720                 2725                 2730             


Leu Glu  Ser Trp Gly Val Arg  Pro Asp Ala Val Val  Gly His Ser 
    2735                 2740                 2745             


Val Gly  Glu Leu Ala Ala Gly  Tyr Val Ser Gly Leu  Trp Ser Leu 
    2750                 2755                 2760             


Glu Asp  Ala Cys Thr Leu Val  Ser Ala Arg Ala Arg  Leu Met Gln 
    2765                 2770                 2775             


Ala Leu  Pro Ala Gly Gly Val  Met Ala Ala Val Pro  Val Ser Glu 
    2780                 2785                 2790             


Asp Glu  Ala Arg Ala Val Leu  Gly Glu Gly Val Glu  Ile Ala Ala 
    2795                 2800                 2805             


Val Asn  Gly Pro Ser Ser Val  Val Leu Ser Gly Asp  Glu Ala Ala 
    2810                 2815                 2820             


Val Leu  Gln Ala Ala Glu Gly  Leu Gly Lys Trp Thr  Arg Leu Pro 
    2825                 2830                 2835             


Thr Ser  His Ala Phe His Ser  Ala Arg Met Glu Pro  Met Leu Glu 
    2840                 2845                 2850             


Glu Phe  Arg Ala Val Ala Glu  Gly Leu Thr Tyr Arg  Thr Pro Gln 
    2855                 2860                 2865             


Val Ala  Met Ala Ala Gly Asp  Gln Val Met Thr Ala  Glu Tyr Trp 
    2870                 2875                 2880             


Val Arg  Gln Val Arg Asp Thr  Val Arg Phe Gly Glu  Gln Val Ala 
    2885                 2890                 2895             


Ser Phe  Glu Asp Ala Val Phe  Val Glu Leu Gly Ala  Asp Arg Ser 
    2900                 2905                 2910             


Leu Ala  Arg Leu Val Asp Gly  Ile Ala Met Leu His  Gly Asp His 
    2915                 2920                 2925             


Glu Ala  Gln Ala Ala Asp His  Arg Gln Ile Thr Glu  Ala Val Ala 
    2930                 2935                 2940             


Asp Ala  Tyr Val Leu Gly His  Leu Pro Asp Phe Ala  Ala Leu Arg 
    2945                 2950                 2955             


Arg Pro  His Ala Arg Lys Leu  Asp Leu Pro Thr Tyr  Pro Phe Glu 
    2960                 2965                 2970             


Arg Arg  Gln Tyr Trp Phe Arg  Asp Ala Arg Glu Arg  Pro Glu Gln 
    2975                 2980                 2985             


Pro Arg  Asp Thr Gly Gly Pro  Arg Thr Glu Ala Val  Arg Leu Leu 
    2990                 2995                 3000             


Glu Asp  Gly Arg Ile Glu Glu  Leu Ala Ala Leu Leu  Gly Gly Ala 
    3005                 3010                 3015             


Ser Asp  Asp Gln His Thr Leu  Gln Val Leu Thr Lys  Leu Ala Ala 
    3020                 3025                 3030             


Gln His  Asn Gln Gln Arg Thr  Thr Arg Ser Ile Ala  Asp Asp Arg 
    3035                 3040                 3045             


Tyr Glu  Ile Arg Trp Asp Arg  Ser Thr Ser Pro Leu  Ser Gly Ala 
    3050                 3055                 3060             


Asp Val  Asp Gln Ala Gly Ser  Trp Ile Val Val Ser  Asp Asp Ala 
    3065                 3070                 3075             


Asp Ala  Val Pro Pro Leu Val  Asp Leu Leu Ala Ala  Arg Asn Glu 
    3080                 3085                 3090             


Pro His  Gln Val Val Gly Leu  Pro Ala Ser Asp Ala  Asp Glu Glu 
    3095                 3100                 3105             


Arg Leu  Ala Glu Thr Leu Arg  Ala Ala Ala Thr Glu  Asp Ala Thr 
    3110                 3115                 3120             


Leu Arg  Ile Val His Val Ala  Ala Leu Glu Ala Gly  Ala Thr Pro 
    3125                 3130                 3135             


Ser Met  Arg Ser Leu Leu Arg  Met Gln His Arg Ile  Leu Gly Gly 
    3140                 3145                 3150             


Thr Arg  Arg Val Phe Arg Ala  Ala Val Ala Ala Glu  Leu Arg Gly 
    3155                 3160                 3165             


Pro Ile  Trp Ile Val Thr Arg  Gly Ala Gln Arg Val  Ala Asp Thr 
    3170                 3175                 3180             


Asp Thr  Val Ala Pro His Gln  Ser Cys Leu Trp Gly  Phe Gly Arg 
    3185                 3190                 3195             


Ala Ala  Ser Leu Glu Leu Pro  His Val Trp Gly Gly  Leu Ala Asp 
    3200                 3205                 3210             


Leu Ser  Glu Gly Gly Asp Asn  Ala Ala Asp Glu Trp  Ser Ala Leu 
    3215                 3220                 3225             


Val Asp  Arg Ile Ala Ala Pro  His Gly Ser Ala Val  Arg Glu Asp 
    3230                 3235                 3240             


Gln Leu  Ala Leu Arg Asp Arg  Ala Val Tyr Thr Pro  Arg Leu Ala 
    3245                 3250                 3255             


Arg Arg  Ser Ala Pro Pro Ser  Gly Thr Pro Leu His  Leu Arg Gly 
    3260                 3265                 3270             


Asp Gly  Thr Val Leu Ile Thr  Gly Gly Thr Gly Thr  Leu Gly Arg 
    3275                 3280                 3285             


Leu Leu  Ala Arg His Leu Val  Thr Glu His Gly Val  Arg His Leu 
    3290                 3295                 3300             


Leu Leu  Val Ser Arg Arg Gly  Ala Asp Ala Pro Gly  Ser Asp Glu 
    3305                 3310                 3315             


Leu Arg  Ala Glu Ile Glu Asp  Leu Gly Ala Ser Ala  Glu Ile Ala 
    3320                 3325                 3330             


Ala Cys  Asp Thr Ala Asp Arg  Asp Ala Leu Ser Ala  Leu Leu Asp 
    3335                 3340                 3345             


Gly Leu  Pro Arg Pro Leu Thr  Gly Val Val His Ala  Ala Gly Val 
    3350                 3355                 3360             


Leu Ala  Asp Gly Leu Val Thr  Ser Ile Asp Glu Pro  Ala Val Glu 
    3365                 3370                 3375             


Gln Val  Leu Arg Ala Lys Val  Asp Ala Ala Trp Asn  Leu His Glu 
    3380                 3385                 3390             


Leu Thr  Ala Asn Thr Gly Leu  Ser Phe Phe Val Leu  Phe Ser Ser 
    3395                 3400                 3405             


Ala Ala  Ser Val Leu Ala Gly  Pro Gly Gln Gly Val  Tyr Ala Ala 
    3410                 3415                 3420             


Ala Asn  Glu Ser Leu Asn Ala  Leu Ala Ala Leu Arg  Arg Thr Arg 
    3425                 3430                 3435             


Gly Leu  Pro Ala Lys Ala Leu  Gly Trp Gly Leu Trp  Ala Ile Gly 
    3440                 3445                 3450             


Arg Ala  Ile Ala Phe Ala Glu  Gln Thr Gly Asp Ala  Ile Ala Pro 
    3455                 3460                 3465             


Glu Glu  Gly Ala Tyr Ala Phe  Glu Thr Leu Leu Arg  His Asn Arg 
    3470                 3475                 3480             


Ala Tyr  Ser Gly Tyr Ala Pro  Val Ile Gly Ser Pro  Trp Leu Thr 
    3485                 3490                 3495             


Ala Phe  Ala Gln His Ser Pro  Phe Ala Glu Lys Phe  Gln Ser Leu 
    3500                 3505                 3510             


Gly Gln  Asn Arg Ser Gly Thr  Ser Lys Phe Leu Ala  Glu Leu Val 
    3515                 3520                 3525             


Asp Leu  Pro Arg Glu Glu Trp  Pro Asp Arg Leu Arg  Arg Leu Leu 
    3530                 3535                 3540             


Glu Leu  Val Arg Ser His Ala  Ala Ala Val Ser Gly  Tyr Gly Ser 
    3545                 3550                 3555             


Ala Asp  Gln Leu Pro Glu Arg  Lys Ala Phe Lys Asp  Leu Gly Phe 
    3560                 3565                 3570             


Asp Ser  Leu Ala Ala Val Glu  Leu Arg Asn Arg Leu  Gly Thr Ala 
    3575                 3580                 3585             


Thr Gly  Val Arg Leu Pro Ser  Thr Leu Val Phe Asp  His Pro Thr 
    3590                 3595                 3600             


Pro Leu  Ala Val Ala Glu His  Leu Arg Asp Arg Leu  Thr Ser Gly 
    3605                 3610                 3615             


Glu Asp  Asn Pro Ile Pro Leu  Cys Gln Gly Asp Gly  Glu Glu Met 
    3620                 3625                 3630             


Ser Thr  Trp Leu Arg Arg Phe  Gly Pro Pro Val Glu  His Arg Ala 
    3635                 3640                 3645             


Arg Leu  Val Cys Phe Pro His  Ala Gly Ala Ala Ala  Asp Ser Tyr 
    3650                 3655                 3660             


Leu Asp  Leu Ala Arg Ala Leu  Ala Pro Glu Ile Asp  Val His Ala 
    3665                 3670                 3675             


Val Gln  Tyr Pro Gly Arg Gln  Asp Arg Arg Asp Glu  Glu Pro Leu 
    3680                 3685                 3690             


Gly Thr  Ala Gly Glu Ile Ala  Asp Glu Val Ala Ala  Val Leu Arg 
    3695                 3700                 3705             


Ala Ser  Gly Gly Asp Gly Pro  Phe Ala Leu Phe Gly  His Ser Met 
    3710                 3715                 3720             


Gly Ala  Leu Ile Ala Tyr Glu  Thr Ala Arg Arg Leu  Glu Arg Glu 
    3725                 3730                 3735             


Pro Gly  Gly Gly Pro Leu Arg  Leu Phe Val Ser Gly  Gln Thr Ala 
    3740                 3745                 3750             


Pro Arg  Val His Glu Arg Arg  Thr Asp Leu Pro Gly  Asp Asp Gly 
    3755                 3760                 3765             


Leu Val  Asp Glu Leu Arg Arg  Leu Gly Thr Ser Glu  Ala Ala Leu 
    3770                 3775                 3780             


Ala Asp  Glu Ala Leu Leu Ala  Met Ser Leu Pro Val  Leu Arg Ala 
    3785                 3790                 3795             


Asp Tyr  Arg Val Leu Arg Ser  Tyr Ala Trp Ala Asp  Gly Pro Pro 
    3800                 3805                 3810             


Leu Arg  Ala Gly Ile Thr Ala  Leu Cys Gly Asp Ala  Asp Pro Leu 
    3815                 3820                 3825             


Thr Ala  Thr Gly Asp Ala Glu  Arg Trp Leu Gln His  Ser Val Ile 
    3830                 3835                 3840             


Pro Gly  Arg Thr Arg Thr Phe  Pro Gly Gly His Phe  Tyr Leu Gly 
    3845                 3850                 3855             


Glu Gln  Val Thr Glu Val Ala  Gly Ala Val Arg Arg  Asp Leu Leu 
    3860                 3865                 3870             


Arg Ala  Gly Leu Ala Gly 
    3875                 


<210>  64
<211>  3992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSS

<400>  64

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Val Pro Val 
            500                 505                 510         


Glu Gln Pro Phe Val His Ser Pro Glu Asp Arg Tyr Gln Pro Phe Ala 
        515                 520                 525             


Leu Thr Asp Val Gln Gln Ala Tyr Leu Val Gly Arg Gln Pro Gly Phe 
    530                 535                 540                 


Ala Leu Gly Gly Val Gly Ser His Phe Phe Val Glu Phe Glu Ile Ala 
545                 550                 555                 560 


Asp Leu Asp Leu Thr Arg Leu Glu Thr Val Trp Asn Arg Leu Ile Ala 
                565                 570                 575     


Arg His Asp Met Leu Arg Ala Ile Val Arg Asp Gly Gln Gln Gln Val 
            580                 585                 590         


Leu Glu Gln Thr Pro Pro Trp Val Ile Pro Ala His Thr Leu His Thr 
        595                 600                 605             


Pro Glu Glu Ala Leu Arg Val Arg Glu Lys Leu Ala His Gln Val Leu 
    610                 615                 620                 


Asn Pro Glu Val Trp Pro Val Phe Asp Leu Gln Val Gly Tyr Val Asp 
625                 630                 635                 640 


Gly Met Pro Ala Arg Leu Trp Leu Cys Leu Asp Asn Leu Leu Leu Asp 
                645                 650                 655     


Gly Leu Ser Met Gln Ile Leu Leu Ala Glu Leu Glu His Gly Tyr Arg 
            660                 665                 670         


Tyr Pro Gln Gln Leu Leu Pro Pro Leu Pro Val Thr Phe Arg Asp Tyr 
        675                 680                 685             


Leu Gln Gln Pro Ser Leu Gln Ser Pro Asn Pro Asp Ser Leu Ala Trp 
    690                 695                 700                 


Trp Gln Ala Gln Leu Asp Asp Ile Pro Pro Ala Pro Ala Leu Pro Leu 
705                 710                 715                 720 


Arg Cys Leu Pro Gln Glu Val Glu Thr Pro Arg Phe Ala Arg Leu Asn 
                725                 730                 735     


Gly Ala Leu Asp Ser Thr Arg Trp His Arg Leu Lys Lys Arg Ala Ala 
            740                 745                 750         


Asp Ala His Leu Thr Pro Ser Ala Val Leu Leu Ser Val Trp Ser Thr 
        755                 760                 765             


Val Leu Ser Ala Trp Ser Ala Gln Pro Glu Phe Thr Leu Asn Leu Thr 
    770                 775                 780                 


Leu Phe Asp Arg Arg Pro Leu His Pro Gln Ile Asn Gln Ile Leu Gly 
785                 790                 795                 800 


Asp Phe Thr Ser Leu Met Leu Leu Ser Trp His Pro Gly Glu Ser Trp 
                805                 810                 815     


Leu His Ser Ala Gln Ser Leu Gln Gln Arg Leu Ser Gln Asn Leu Asn 
            820                 825                 830         


His Arg Asp Val Ser Ala Ile Arg Val Met Arg Gln Leu Ala Gln Gln 
        835                 840                 845             


Gln Asn Val Pro Ala Val Pro Met Pro Val Val Phe Thr Ser Ala Leu 
    850                 855                 860                 


Gly Phe Glu Gln Asp Asn Phe Leu Ala Arg Arg Asn Leu Leu Lys Pro 
865                 870                 875                 880 


Val Trp Gly Ile Ser Gln Thr Pro Gln Val Trp Leu Asp His Gln Ile 
                885                 890                 895     


Tyr Glu Ser Glu Gly Glu Leu Arg Phe Asn Trp Asp Phe Val Ala Ala 
            900                 905                 910         


Leu Phe Pro Ala Gly Gln Val Glu Arg Gln Phe Glu Gln Tyr Cys Ala 
        915                 920                 925             


Leu Leu Asn Arg Met Ala Glu Asp Glu Ser Gly Trp Gln Leu Pro Leu 
    930                 935                 940                 


Ala Ala Leu Val Pro Pro Val Lys His Ala Gly Gln Cys Ala Glu Arg 
945                 950                 955                 960 


Ser Pro Arg Val Cys Pro Glu Gln Ser Gln Pro His Ile Ala Ala Asp 
                965                 970                 975     


Glu Ser Thr Val Ser Leu Ile Cys Asp Ala Phe Arg Glu Val Val Gly 
            980                 985                 990         


Glu Ser Val Thr Pro Ala Glu Asn  Phe Phe Glu Ala Gly  Ala Thr Ser 
        995                 1000                 1005             


Leu Asn  Leu Val Gln Leu His  Val Leu Leu Gln Arg  His Glu Phe 
    1010                 1015                 1020             


Ser Thr  Leu Thr Leu Leu Asp  Leu Phe Thr His Pro  Ser Pro Ala 
    1025                 1030                 1035             


Ala Leu  Ala Asp Tyr Leu Ala  Gly Val Ala Thr Val  Glu Lys Thr 
    1040                 1045                 1050             


Lys Arg  Pro Arg Pro Val Arg  Arg Arg Gln Arg Arg  Ile Gln His 
    1055                 1060                 1065             


Leu Pro  Leu Val Ala Ala Gln  Pro Gly Ile Trp Met  Ala Glu Lys 
    1070                 1075                 1080             


Leu Ser  Glu Leu Pro Ser Ala  Trp Ser Val Ala His  Tyr Val Glu 
    1085                 1090                 1095             


Leu Thr  Gly Glu Val Asp Ser  Pro Leu Leu Ala Arg  Ala Val Val 
    1100                 1105                 1110             


Ala Gly  Leu Ala Gln Ala Asp  Thr Leu Arg Met Arg  Phe Thr Glu 
    1115                 1120                 1125             


Asp Asn  Gly Glu Val Trp Gln  Trp Val Asp Asp Ala  Leu Thr Phe 
    1130                 1135                 1140             


Glu Leu  Pro Glu Ile Ile Asp  Leu Arg Thr Asn Ile  Asp Pro His 
    1145                 1150                 1155             


Gly Thr  Ala Gln Ala Leu Met  Gln Ala Asp Leu Gln  Gln Asp Leu 
    1160                 1165                 1170             


Arg Val  Asp Ser Gly Lys Pro  Leu Val Phe His Gln  Leu Ile Gln 
    1175                 1180                 1185             


Val Ala  Asp Asn Arg Trp Tyr  Trp Tyr Gln Arg Tyr  His His Leu 
    1190                 1195                 1200             


Leu Val  Asp Gly Phe Ser Phe  Pro Ala Ile Thr Arg  Gln Ile Ala 
    1205                 1210                 1215             


Asn Ile  Tyr Cys Thr Trp Leu  Arg Gly Glu Pro Thr  Pro Ala Ser 
    1220                 1225                 1230             


Pro Phe  Thr Pro Phe Ala Asp  Val Val Glu Glu Tyr  Gln Gln Tyr 
    1235                 1240                 1245             


Arg Glu  Ser Glu Ala Trp Gln  Arg Asp Ala Ala Phe  Trp Ala Glu 
    1250                 1255                 1260             


Gln Arg  Arg Gln Leu Pro Pro  Pro Ala Ser Leu Ser  Pro Ala Pro 
    1265                 1270                 1275             


Leu Pro  Gly Arg Ser Ala Ser  Ala Asp Ile Leu Arg  Leu Lys Leu 
    1280                 1285                 1290             


Glu Phe  Thr Asp Gly Glu Phe  Arg Gln Leu Ala Thr  Gln Leu Ser 
    1295                 1300                 1305             


Gly Val  Gln Arg Thr Asp Leu  Ala Leu Ala Leu Ala  Ala Leu Trp 
    1310                 1315                 1320             


Leu Gly  Arg Leu Cys Asn Arg  Met Asp Tyr Ala Ala  Gly Phe Ile 
    1325                 1330                 1335             


Phe Met  Arg Arg Leu Gly Ser  Ala Ala Leu Thr Ala  Thr Gly Pro 
    1340                 1345                 1350             


Val Leu  Asn Val Leu Pro Leu  Gly Ile His Ile Gly  Asn Pro Ser 
    1355                 1360                 1365             


Phe Ser  Glu Leu Leu Thr Arg  Val Arg Glu Val Ala  Leu Gly Ala 
    1370                 1375                 1380             


Tyr Ala  His Gln His Ile Pro  Phe Glu Met Leu Val  Glu Ala Leu 
    1385                 1390                 1395             


Gln Pro  Glu Arg Asn Leu Ser  His Thr Pro Leu Phe  Gln Val Met 
    1400                 1405                 1410             


Phe Val  Leu Gln Asn Ala Pro  Ala Ser Gln Leu Glu  Leu Thr Gly 
    1415                 1420                 1425             


Ile Thr  Ala Asn Pro Ile Lys  Val Lys Ser Thr Thr  Thr Lys Phe 
    1430                 1435                 1440             


Asp Leu  Thr Leu Ile Met Gln  Asn Thr Ala Ser Gly  Leu Val Gly 
    1445                 1450                 1455             


Val Trp  Glu Tyr Asn Thr Asp  Leu Phe Asp Ala Ser  Thr Ile Glu 
    1460                 1465                 1470             


Arg Met  Thr Gly His Phe Val  Thr Leu Leu Glu Gly  Val Ile Ala 
    1475                 1480                 1485             


Asn Pro  Gln Gln Pro Ile Ser  Gln Leu Pro Ile Leu  Thr Thr Val 
    1490                 1495                 1500             


Glu Gln  Gln Gln Leu Leu Val  Glu Trp Asn Asn Thr  Gln Thr Asp 
    1505                 1510                 1515             


Tyr Pro  Ala Asp Lys Cys Ile  His Gln Leu Phe Glu  Glu Gln Val 
    1520                 1525                 1530             


Glu Arg  Thr Pro Asp Ala Val  Ala Val Val Phe Gly  Asn Gln Gln 
    1535                 1540                 1545             


Leu Ser  Tyr Arg Glu Met Arg  Glu Gln Val Val Ala  Leu Ala Asn 
    1550                 1555                 1560             


Leu Leu  Arg Glu Arg Gly Val  Lys Pro Gly Asp Ser  Val Ala Val 
    1565                 1570                 1575             


Ala Leu  Pro Arg Ser Val Phe  Leu Thr Leu Ala Leu  His Ala Ile 
    1580                 1585                 1590             


Val Glu  Ala Gly Ala Ala Trp  Leu Pro Leu Asp Thr  Gly Tyr Pro 
    1595                 1600                 1605             


Asp Asp  Arg Leu Lys Met Met  Leu Glu Asp Ala Arg  Pro Ser Leu 
    1610                 1615                 1620             


Leu Ile  Thr Thr Asp Asp Gln  Leu Pro Arg Phe Ser  Asp Val Pro 
    1625                 1630                 1635             


Asn Leu  Thr Ser Leu Cys Tyr  Asn Ala Pro Leu Thr  Pro Gln Gly 
    1640                 1645                 1650             


Ser Ala  Pro Leu Gln Leu Ser  Gln Pro His His Thr  Ala Tyr Ile 
    1655                 1660                 1665             


Ile Phe  Thr Ser Gly Ser Thr  Gly Arg Pro Lys Gly  Val Met Val 
    1670                 1675                 1680             


Gly Gln  Thr Ala Ile Val Asn  Arg Leu Leu Trp Met  Gln Asn His 
    1685                 1690                 1695             


Tyr Pro  Leu Thr Gly Glu Asp  Val Val Ala Gln Lys  Thr Pro Cys 
    1700                 1705                 1710             


Ser Phe  Asp Val Ser Val Trp  Glu Phe Phe Trp Pro  Phe Ile Ala 
    1715                 1720                 1725             


Gly Ala  Lys Leu Val Met Ala  Glu Pro Glu Ala His  Arg Asp Pro 
    1730                 1735                 1740             


Leu Ala  Met Gln Gln Phe Phe  Ala Glu Tyr Gly Val  Thr Thr Thr 
    1745                 1750                 1755             


His Phe  Val Pro Ser Met Leu  Ala Ala Phe Val Ala  Ser Leu Thr 
    1760                 1765                 1770             


Pro Gln  Thr Ala Arg Gln Ser  Cys Ala Thr Leu Lys  Gln Val Phe 
    1775                 1780                 1785             


Cys Ser  Gly Glu Ala Leu Pro  Ala Asp Leu Cys Arg  Glu Trp Gln 
    1790                 1795                 1800             


Gln Leu  Thr Gly Ala Pro Leu  His Asn Leu Tyr Gly  Pro Thr Glu 
    1805                 1810                 1815             


Ala Ala  Val Asp Val Ser Trp  Tyr Pro Ala Phe Gly  Glu Glu Leu 
    1820                 1825                 1830             


Ala Gln  Val Arg Gly Ser Ser  Val Pro Ile Gly Tyr  Pro Val Trp 
    1835                 1840                 1845             


Asn Thr  Gly Leu Arg Ile Leu  Asp Ala Met Met His  Pro Val Pro 
    1850                 1855                 1860             


Pro Gly  Val Ala Gly Asp Leu  Tyr Leu Thr Gly Ile  Gln Leu Ala 
    1865                 1870                 1875             


Gln Gly  Tyr Leu Gly Arg Pro  Asp Leu Thr Ala Ser  Arg Phe Ile 
    1880                 1885                 1890             


Ala Asp  Pro Phe Ala Pro Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    1895                 1900                 1905             


Val Ala  Arg Trp Leu Asp Asn  Gly Ala Val Glu Tyr  Leu Gly Arg 
    1910                 1915                 1920             


Ser Asp  Asp Gln Leu Lys Ile  Arg Gly Gln Arg Ile  Glu Leu Gly 
    1925                 1930                 1935             


Glu Ile  Asp Arg Val Met Gln  Ala Leu Pro Asp Val  Glu Gln Ala 
    1940                 1945                 1950             


Val Ala  Ser Cys Ala Ile Ala  Arg Glu Asp Ile Pro  Gly Asn Lys 
    1955                 1960                 1965             


His Leu  Val Ala Tyr Ile Val  Pro Gln Glu Glu Gln  Thr Cys Thr 
    1970                 1975                 1980             


Glu Arg  Ser Arg Ser Thr Leu  Thr Val Ser Phe Val  Arg Ser Phe 
    1985                 1990                 1995             


Leu Lys  Glu Lys Leu Pro Glu  Tyr Met Val Pro Ser  Ala Ile Val 
    2000                 2005                 2010             


Ile Leu  Asp Ala Leu Pro Leu  Thr Pro Asn Gly Lys  Leu Asp Arg 
    2015                 2020                 2025             


Arg Ala  Leu Pro Ala Pro Asp  Leu His Ser Gln Leu  Glu Thr Ile 
    2030                 2035                 2040             


Ile Ala  Ala Ala Phe Ser Ser  Leu Leu Gly Cys Asp  Val Gln Asp 
    2045                 2050                 2055             


Ala Asp  Ala Asp Phe Phe Ala  Leu Gly Gly His Ser  Leu Leu Ala 
    2060                 2065                 2070             


Met Lys  Leu Ala Ala Gln Leu  Ser Arg Gln Val Ala  Arg Gln Val 
    2075                 2080                 2085             


Thr Pro  Gly Gln Val Met Val  Ala Ser Thr Val Ala  Lys Leu Ala 
    2090                 2095                 2100             


Thr Ile  Ile Asp Ala Glu Leu  Asp Lys Tyr Val Ala  Pro Arg Asn 
    2105                 2110                 2115             


Pro Ile  Leu Pro Val Glu Gln  Pro Phe Val His Ser  Pro Glu Glu 
    2120                 2125                 2130             


Arg Tyr  Arg Pro Phe Ala Leu  Thr Asp Val Gln Gln  Ala Tyr Leu 
    2135                 2140                 2145             


Val Gly  Arg Gln Pro Gly Phe  Ala Leu Gly Gly Val  Gly Ser His 
    2150                 2155                 2160             


Phe Phe  Val Glu Phe Glu Ile  Ala Asp Leu Asp Ile  His Arg Leu 
    2165                 2170                 2175             


Glu Lys  Val Trp Asn Arg Leu  Ile Ala Arg His Asp  Met Leu Arg 
    2180                 2185                 2190             


Ala Val  Val Arg Asp Gly Gln  Gln Arg Val Leu Glu  Gln Thr Pro 
    2195                 2200                 2205             


Pro Trp  Val Ile Pro Ala His  Ile Leu His Ser Pro  Glu Glu Ala 
    2210                 2215                 2220             


Leu Gln  Val Arg Asp Arg Leu  Ala His Gln Val Leu  Asn Pro Glu 
    2225                 2230                 2235             


Val Trp  Pro Val Phe Asp Leu  Gln Val Gly Phe Val  Asp Gly Met 
    2240                 2245                 2250             


Pro Ala  Arg Leu Trp Leu Cys  Leu Asp Asn Leu Leu  Leu Asp Gly 
    2255                 2260                 2265             


Leu Ser  Met Gln Ile Leu Leu  Ser Glu Leu Glu His  Gly Tyr Arg 
    2270                 2275                 2280             


Tyr Pro  Gln Gln Leu Pro Pro  Pro Leu Pro Ile Thr  Phe Arg Asp 
    2285                 2290                 2295             


Tyr Leu  Gln Gln Pro Ala Leu  Arg Thr Pro Asn Pro  Asp Ser Leu 
    2300                 2305                 2310             


Ala Trp  Trp Gln Thr Gln Leu  Asp Asp Ile Pro Pro  Ala Pro Ala 
    2315                 2320                 2325             


Leu Pro  Leu Arg Cys Leu Pro  Gln Asp Val Glu Thr  Pro Arg Phe 
    2330                 2335                 2340             


Ala Arg  Leu Tyr Gly Ala Met  Asp Ser Ala Arg Trp  Arg Arg Leu 
    2345                 2350                 2355             


Lys Gln  Arg Ala Ala Asp Ala  His Leu Thr Pro Ser  Ala Val Leu 
    2360                 2365                 2370             


Leu Ser  Val Trp Ser Thr Val  Leu Ala Ala Trp Ser  Ala Gln Pro 
    2375                 2380                 2385             


Asp Phe  Thr Leu Asn Leu Thr  Leu Phe Asp Arg Arg  Pro Leu His 
    2390                 2395                 2400             


Pro Gln  Ile Asn Gln Ile Leu  Gly Asp Phe Thr Ser  Leu Met Leu 
    2405                 2410                 2415             


Leu Ser  Trp His Pro Gly Glu  Ser Trp Leu Gln Ser  Ala Arg Leu 
    2420                 2425                 2430             


Leu Gln  Gln Arg Leu Ser Glu  Ser Leu Asn His Arg  Asp Val Ser 
    2435                 2440                 2445             


Ala Ile  Arg Val Met Arg Gln  Leu Ala Arg Arg Gln  Asn Val Pro 
    2450                 2455                 2460             


Ala Val  Pro Met Pro Val Val  Phe Thr Ser Ala Leu  Gly Phe Glu 
    2465                 2470                 2475             


Gln Asp  Asn Phe Leu Ala Arg  Arg Asn Leu Leu Lys  Pro Val Trp 
    2480                 2485                 2490             


Gly Ile  Ser Gln Thr Pro Gln  Val Trp Leu Asp His  Gln Val Tyr 
    2495                 2500                 2505             


Glu Ser  Glu Gly Glu Leu Arg  Phe Asn Trp Asp Phe  Val Ala Ala 
    2510                 2515                 2520             


Leu Phe  Pro Asp Gly Gln Val  Glu Arg Gln Phe Ala  Gln Tyr Cys 
    2525                 2530                 2535             


Ala Leu  Leu Asn Arg Met Ala  Glu Asp Asp Ser Ser  Trp Gln Leu 
    2540                 2545                 2550             


Pro Leu  Ala Asp Leu Val Pro  Pro Leu Lys Val Thr  Glu Arg Arg 
    2555                 2560                 2565             


Ala Arg  Arg Leu Arg Pro Glu  Arg Ala Gln Pro Arg  Ile Ala Ala 
    2570                 2575                 2580             


Asp Lys  Ser Ser Val Ser Leu  Ile Cys Asp Thr Phe  Arg Glu Val 
    2585                 2590                 2595             


Val Gly  Glu Pro Val Ala Pro  Ala Glu Asn Phe Phe  Glu Ala Gly 
    2600                 2605                 2610             


Ala Thr  Ser Leu Asn Leu Val  Gln Leu His Val Leu  Leu Gln Arg 
    2615                 2620                 2625             


His Glu  Phe Ala Thr Leu Thr  Leu Leu Asp Leu Phe  Thr His Pro 
    2630                 2635                 2640             


Ser Pro  Val Ala Leu Ala Asn  Tyr Leu Ala Gly Val  Ala Leu Glu 
    2645                 2650                 2655             


Glu Lys  Thr Lys Arg Val Arg  Pro Val Arg Arg Arg  Gln Arg Arg 
    2660                 2665                 2670             


Ile Gln  His Leu Pro Leu Val  Ala Ala Gln Pro Gly  Ile Trp Met 
    2675                 2680                 2685             


Ala Glu  Lys Leu Ser Glu Leu  Pro Ser Ala Trp Ser  Val Ala His 
    2690                 2695                 2700             


Tyr Val  Glu Leu Thr Gly Glu  Val Asp Ser Pro Leu  Leu Ala Arg 
    2705                 2710                 2715             


Ala Val  Val Ala Gly Leu Ala  Gln Ala Asp Thr Leu  Arg Met Arg 
    2720                 2725                 2730             


Phe Thr  Glu Asp Asn Gly Glu  Val Trp Gln Trp Val  Asp Asp Ala 
    2735                 2740                 2745             


Leu Thr  Phe Glu Leu Pro Glu  Ile Ile Asp Leu Arg  Thr Asn Ile 
    2750                 2755                 2760             


Asp Pro  His Gly Thr Ala Gln  Ala Leu Met Gln Ala  Asp Leu Gln 
    2765                 2770                 2775             


Gln Asp  Leu Arg Val Asp Ser  Gly Lys Pro Leu Val  Phe His Gln 
    2780                 2785                 2790             


Leu Ile  Gln Val Ala Asp Asn  Arg Trp Tyr Trp Tyr  Gln Arg Tyr 
    2795                 2800                 2805             


His His  Leu Leu Val Asp Gly  Phe Ser Phe Pro Ala  Ile Thr Arg 
    2810                 2815                 2820             


Gln Ile  Ala Asn Ile Tyr Cys  Thr Trp Leu Arg Gly  Glu Pro Thr 
    2825                 2830                 2835             


Pro Ala  Ser Pro Phe Thr Pro  Phe Ala Asp Val Val  Glu Glu Tyr 
    2840                 2845                 2850             


Gln Gln  Tyr Arg Glu Ser Glu  Ala Trp Gln Arg Asp  Ala Ala Phe 
    2855                 2860                 2865             


Trp Ala  Glu Gln Arg Arg Gln  Leu Pro Pro Pro Ala  Ser Leu Ser 
    2870                 2875                 2880             


Pro Ala  Pro Leu Pro Gly Arg  Ser Ala Ser Ala Asp  Ile Leu Arg 
    2885                 2890                 2895             


Leu Lys  Leu Glu Phe Thr Asp  Gly Glu Phe Arg Gln  Leu Ala Thr 
    2900                 2905                 2910             


Gln Leu  Ser Gly Val Gln Arg  Thr Asp Leu Ala Leu  Ala Leu Ala 
    2915                 2920                 2925             


Ala Leu  Trp Leu Gly Arg Leu  Cys Asn Arg Met Asp  Tyr Ala Ala 
    2930                 2935                 2940             


Gly Phe  Ile Phe Met Arg Arg  Leu Gly Ser Ala Ala  Leu Thr Ala 
    2945                 2950                 2955             


Thr Gly  Pro Val Leu Asn Val  Leu Pro Leu Gly Ile  His Ile Gly 
    2960                 2965                 2970             


Asn Pro  Ser Phe Ser Glu Leu  Leu Thr Arg Val Arg  Glu Val Ala 
    2975                 2980                 2985             


Leu Gly  Ala Tyr Ala His Gln  His Ile Pro Phe Glu  Met Leu Val 
    2990                 2995                 3000             


Glu Ala  Leu Gln Pro Glu Arg  Asn Leu Ser His Thr  Pro Leu Phe 
    3005                 3010                 3015             


Gln Val  Met Phe Val Leu Gln  Asn Ala Pro Ala Ser  Gln Leu Glu 
    3020                 3025                 3030             


Leu Thr  Gly Ile Thr Ala Asn  Pro Ile Lys Val Lys  Ser Thr Thr 
    3035                 3040                 3045             


Thr Lys  Phe Asp Leu Thr Leu  Ile Met Gln Asn Thr  Ala Ser Gly 
    3050                 3055                 3060             


Leu Val  Gly Val Trp Glu Tyr  Asn Thr Asp Leu Phe  Asp Ala Ser 
    3065                 3070                 3075             


Thr Ile  Glu Arg Met Thr Gly  His Phe Val Thr Leu  Leu Glu Gly 
    3080                 3085                 3090             


Val Ile  Ala Asn Pro Gln Gln  Pro Ile Ser Gln Leu  Pro Ile Leu 
    3095                 3100                 3105             


Thr Thr  Val Glu Gln Gln Gln  Leu Leu Val Glu Trp  Asn Asn Thr 
    3110                 3115                 3120             


Gln Thr  Asp Tyr Pro Ala Asp  Lys Cys Ile His Gln  Leu Phe Glu 
    3125                 3130                 3135             


Glu Gln  Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
    3140                 3145                 3150             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    3155                 3160                 3165             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    3170                 3175                 3180             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    3185                 3190                 3195             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    3200                 3205                 3210             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    3215                 3220                 3225             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    3230                 3235                 3240             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    3245                 3250                 3255             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    3260                 3265                 3270             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    3275                 3280                 3285             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    3290                 3295                 3300             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    3305                 3310                 3315             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    3320                 3325                 3330             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    3335                 3340                 3345             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    3350                 3355                 3360             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    3365                 3370                 3375             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    3380                 3385                 3390             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    3395                 3400                 3405             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    3410                 3415                 3420             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    3425                 3430                 3435             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    3440                 3445                 3450             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    3455                 3460                 3465             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    3470                 3475                 3480             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    3485                 3490                 3495             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    3500                 3505                 3510             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    3515                 3520                 3525             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    3530                 3535                 3540             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    3545                 3550                 3555             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    3560                 3565                 3570             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    3575                 3580                 3585             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    3590                 3595                 3600             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    3605                 3610                 3615             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    3620                 3625                 3630             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    3635                 3640                 3645             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    3650                 3655                 3660             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    3665                 3670                 3675             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    3680                 3685                 3690             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    3695                 3700                 3705             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    3710                 3715                 3720             


Pro Arg  Asn Pro Ile Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    3725                 3730                 3735             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    3740                 3745                 3750             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    3755                 3760                 3765             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    3770                 3775                 3780             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    3785                 3790                 3795             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    3800                 3805                 3810             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    3815                 3820                 3825             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    3830                 3835                 3840             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    3845                 3850                 3855             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    3860                 3865                 3870             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    3875                 3880                 3885             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    3890                 3895                 3900             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    3905                 3910                 3915             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    3920                 3925                 3930             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    3935                 3940                 3945             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    3950                 3955                 3960             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    3965                 3970                 3975             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    3980                 3985                 3990         


<210>  65
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  65

Asp Leu Ala Lys His Gly Thr Glu Asp Ile Asn Val Trp Arg Asp Ser 
1               5                   10                  15      


Gly Phe Asx Ala Ser Asx Val Thr Leu Val Ile Asp Asn Val Asp Asn 
            20                  25                  30          


Val Ala Arg Asx Asp Phe His Lys Asx Gly Ala Leu Trp Ile 
        35                  40                  45      


<210>  66
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  66
cgatcagtca gtcgatcgaa tcgactgatc cacgactgca tcgaca                      46


<210>  67
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  67

Ala Trp Ser Asn Ile Ser Lys Ser Phe Ala Thr Phe Pro Tyr Tyr Arg 
1               5                   10                  15      


Val Ser Asp Asn Leu Leu Ser Lys Lys 
            20                  25  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  68

Asn His Ile Cys Met Phe Val Arg Glu Tyr 
1               5                   10  


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial construct

<400>  69
acggtattgc agcagcttca t                                                 21


<210>  70
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP Condensation

<400>  70

Ala Ala Ile Arg Ser Asn Val Asp Pro Thr Gly Pro Thr Pro Leu Thr 
1               5                   10                  15      


Pro Ile Gln Leu Trp Phe Phe Gln Gln Glu Leu Pro Glu Pro Ser Leu 
            20                  25                  30          


Phe Thr Gln Ser Val Leu Leu Glu Val Pro Ala Asn Thr Asp Ala Glu 
        35                  40                  45              


Arg Leu Ser Thr Ala Leu Leu Gln Leu Cys Glu Cys His Ala Ala Leu 
    50                  55                  60                  


Arg Leu Arg Phe His Arg Ala Lys Asp Gly Trp Gln Gln Phe Ile Pro 
65                  70                  75                  80  


Ala Ala Thr Val Pro Pro Asp Phe Glu Thr His Thr Leu Ala Thr Pro 
                85                  90                  95      


Ser Glu Met Glu Gln Leu Thr Gln Ala Ala Glu Ala Arg Ile Asp Ile 
            100                 105                 110         


Val His Gly Pro Leu Leu Ala Ala Arg Leu Phe Thr Phe Ser Asp Gly 
        115                 120                 125             


Ser Pro Ser Arg Leu Phe Phe Thr Ile His His Leu Ala Val Asp Gly 
    130                 135                 140                 


Val Ser Trp Arg Ile Leu Leu Glu Asp Leu Tyr Arg Ala Tyr His Gln 
145                 150                 155                 160 


Gln Pro Leu Ala Pro Pro Ala Thr Ser Phe Arg Glu Trp Ser Leu His 
                165                 170                 175     


Leu Arg Asp Val Ala Lys Ser Pro Ser Leu Ala Asp Glu Val Ser Phe 
            180                 185                 190         


Trp Gln Gln Val Pro Ser Cys Asn Leu Trp Pro Thr Gln Glu Lys Asn 
        195                 200                 205             


Leu Val Ser Glu Glu Ala Ser Cys Ser Phe Glu Leu Asp Glu His Ala 
    210                 215                 220                 


Thr Ala Ala Leu Leu Arg Gln Ala Pro Arg Thr Tyr Asn Ala Ser Ile 
225                 230                 235                 240 


Gln Glu Leu Leu Val Ala Ala Leu Ala Gln Gly Val Ala Ser Thr Thr 
                245                 250                 255     


Gly His Ser Arg Val Thr Leu Asp Val Glu Arg His Gly Arg His Ala 
            260                 265                 270         


Ser Asp Pro Gln Thr Asp Leu Ser Arg Thr Val Gly Trp Phe Thr Thr 
        275                 280                 285             


Ile Tyr Pro Val Ser Val Ser Val Ala Val Ser Ala Ser Ile Arg Asp 
    290                 295                 300                 


Ser Val Pro Ser Val Arg Glu Gln Leu Arg Arg Ile Pro Glu Glu Gly 
305                 310                 315                 320 


Phe His Tyr Pro Ile Leu Arg Tyr Leu Ala Ala Pro Asn Ala Phe Arg 
                325                 330                 335     


Asp Ser Gln Pro Ser Pro Ile Leu Phe Asn Tyr His Gly Gln Ile Asp 
            340                 345                 350         


Thr Ala Leu Gln Gln Thr Val Glu Trp Lys Pro Ala Ser Glu Ile Val 
        355                 360                 365             


Thr Pro Leu Arg Ser Leu Arg Ala Arg Arg Ser His Leu Phe Glu Ile 
    370                 375                 380                 


Ile Ser Ala Val Ser Asn Asn Arg Leu Gln Val Glu Trp His Tyr Asn 
385                 390                 395                 400 


Ser Arg Leu Gln Glu Arg Ser Ala Ile Glu Ala Leu Ala Ser Asn Phe 
                405                 410                 415     


Gln Gln Gln Leu Ile Ala Leu Cys His Pro Pro Ile His Leu Gln Ser 
            420                 425                 430         


Ser Pro Ala Ile Val 
        435         


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP Heterocyclization

<400>  71

Glu Glu Ala Leu Asn Ile Asp Gly Leu Ala Val Val His Asp Pro Glu 
1               5                   10                  15      


Asp 
    


<210>  72
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACP-KS

<400>  72
ggtctgccgc aagaaataaa acacacgccg gccgttcgta cgacgagcga agacccg          57


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP-KS

<400>  73

Leu Gly Thr Asp Ser Lys Leu Pro Gly Gly Arg Arg Gly Thr Ser Asp 
1               5                   10                  15      


Glu Pro 
        


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP-KS

<400>  74

Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser 
1               5                   10                  15      


Glu Asp Pro 
            


<210>  75
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACP-TE

<400>  75
acgtcgggtg aagacaatcc aatcccgtta tgtcagggtg acggtgaaga g                51


<210>  76
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP-TE

<400>  76

Val Asp Thr Thr Ala Ala Glu Thr Gly Gly Asp Thr Leu Ser Ala Leu 
1               5                   10                  15      


Phe Arg Ser Gly Leu Glu Ala Gly Ala Val Gly Glu Ala Tyr Asp Leu 
            20                  25                  30          


Leu Arg Ser Val Val Arg Leu Arg Pro Arg Phe Arg Thr Val Asp Glu 
        35                  40                  45              


Val Gly Asp Leu Ala Pro Ala Val Thr Leu Arg Glu Ser Asp Ser Glu 
    50                  55                  60                  


Leu Pro Arg Leu Ile Cys Leu Ser Thr 
65                  70              


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP-TE

<400>  77

Thr Ser Gly Glu Asp Asn Pro Ile Pro Leu Cys Gln Gly Asp Gly Glu 
1               5                   10                  15      


Glu 
    


<210>  78
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-PCP

<400>  78

Pro Val Gln Val Asn Asn Gln Thr Gln Leu Ser Ala Tyr Cys Gln Thr 
1               5                   10                  15      


Asp Lys Thr Leu Glu Ile Ala Glu Ile Arg Glu Phe Leu Ala Lys Phe 
            20                  25                  30          


Leu Pro Val Tyr Met Ile Pro Ser Tyr Phe Ile Phe Leu Lys Gln Phe 
        35                  40                  45              


Pro Leu Thr Arg His Gly Lys Leu Asp Leu His Ser Leu Arg Glu Leu 
    50                  55                  60                  


Lys Glu Thr Ser Lys Ser Leu Val Asn Ser Asn Tyr Val Ala Pro Arg 
65                  70                  75                  80  


Asn His Leu 
            


<210>  79
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AT-ACP

<400>  79

Lys Ala Ala Ala Pro Ala Arg Ala Ala Lys Pro Ala Ala Thr Pro Glu 
1               5                   10                  15      


Ser Leu Pro Phe Val Leu Ser Ala Phe Thr Val Pro Ala Leu Arg Ala 
            20                  25                  30          


Gln Ala Asp Lys Leu His Leu His Met Gly Met Asn Ile Gln Asp Arg 
        35                  40                  45              


Phe Leu Asp Val Ala Tyr Ser Leu Ala Thr Thr Arg Thr His Phe Arg 
    50                  55                  60                  


Lys Arg Leu Val Val Phe Ala Lys Gly Lys Ser Asp Leu Leu Asp Ala 
65                  70                  75                  80  


Leu Ala Ser Tyr Gly Arg Thr Gly Glu Val Pro Ala Gly Ala Val Ser 
                85                  90                  95      


Met Val Asp Asp Arg Asp Arg Glu Cys Arg Leu Ala Leu 
            100                 105                 


<210>  80
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AT-DH

<400>  80
gggatgcgtc gtgaacaacc actgccgtta ggtctgcgtc gtttactgac ggatctgcac       60

aatgcagggg ccgccgttga cttctcggtt ctgtgtccgc aagggcgtct ggttgacgcc      120

ccgttaccgg cctggagcca ccggttcctg ttctacgatc gtgagggtgt tgacaatcgt      180

tcgccaggtg gtagcacggt tgccgtt                                          207


<210>  81
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AT-DH

<400>  81

Ala Lys Asp Glu Thr Gln Thr Met Gln Lys Gly Leu Ala Glu Leu His 
1               5                   10                  15      


Val Leu Gly Ala Pro Val Asp Trp Arg Gly Phe Phe Ala Pro Tyr Gly 
            20                  25                  30          


Gly Glu Arg Val Lys Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg Tyr 
        35                  40                  45              


Trp Leu Glu Pro Met Pro Thr Arg Ala Val Gly Ala Gly Leu Asn Asp 
    50                  55                  60                  


Ala Asn 
65      


<210>  82
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AT-DH

<400>  82

Gly Met Arg Arg Glu Gln Pro Leu Pro Leu Gly Leu Arg Arg Leu Leu 
1               5                   10                  15      


Thr Asp Leu His Asn Ala Gly Ala Ala Val Asp Phe Ser Val Leu Cys 
            20                  25                  30          


Pro Gln Gly Arg Leu Val Asp Ala Pro Leu Pro Ala Trp Ser His Arg 
        35                  40                  45              


Phe Leu Phe Tyr Asp Arg Glu Gly Val Asp Asn Arg Ser Pro Gly Gly 
    50                  55                  60                  


Ser Thr Val Ala Val 
65                  


<210>  83
<211>  1026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AT-KR

<400>  83
gccgatcacc ggcagatcac ggaagcagtt gccgacgcct acgttctggg gcacctgcca       60

gatttcgccg ccctgcggcg tccgcacgcc cgtaagctgg acctgccaac ctacccgttc      120

gagcgtcggc agtactggtt ccgtgatgca cgtgagcgtc cagaacagcc acgtgatacg      180

ggtgggccgc gtacggaggc cgttcgtctg ttagaagatg ggcgtatcga agagctggca      240

gccttactgg gtggtgccag cgacgaccag cacacgttac aggttctgac caagctggcc      300

gcccagcaca atcaacaacg tacgacgcgt tcgatagccg atgatcgtta cgaaatccgg      360

tgggatcgta gcacgagccc actgagcggg gccgacgttg accaggccgg ttcgtggatc      420

gttgttagcg acgacgccga cgccgttccg ccactggttg atttactggc cgcccgtaat      480

gagccgcacc aagttgttgg tttaccggcc agcgacgccg atgaggaacg gctggccgaa      540

acgctgcggg ccgccgccac cgaagacgcc accttacgta tcgttcacgt tgccgccctg      600

gaggccggtg ccacgccgtc gatgcggagc ctgctgcgga tgcagcaccg tatcctgggg      660

ggtacgcgtc gtgttttccg ggccgccgtt gccgccgaac tgcggggtcc gatctggatc      720

gttacccggg gtgcccagcg tgttgcagat acggacaccg ttgcaccaca ccagagctgt      780

ttatggggtt tcggtcgtgc agcctcgctg gagctgccac acgtttgggg tggtctggca      840

gacctgtcgg agggtggtga taatgcagca gacgaatggt cggcactggt tgaccggatc      900

gccgccccgc acggtagcgc agttcgggaa gatcagttag ccctgcgtga tcgggccgtt      960

tacaccccgc gtttagcccg tcgtagcgca ccaccgagcg ggaccccgtt acacctgcgt     1020

ggtgac                                                                1026


<210>  84
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AT-KR

<400>  84

Ala His Pro Gln Gln Arg Asp Arg Asp Ala Gln Gln Leu Ala Gln Ala 
1               5                   10                  15      


Leu Ala Gly Leu Trp Thr Ala Gly Val Glu Ile Asp Trp Pro Ala Thr 
            20                  25                  30          


Arg Gly Gly Ala Arg Arg Arg Asn Val Pro Leu Pro Thr Tyr Pro Phe 
        35                  40                  45              


Gln Arg Gln Arg Phe Trp Val Glu Ala Gly Ala Pro Arg Pro Gln Asp 
    50                  55                  60                  


Asp Ala Ser Ala Ala Gln Pro Gln Gly Leu Tyr Tyr Leu Pro Ala Trp 
65                  70                  75                  80  


Val Val Gln Arg Ser Gly Ala Val Pro Pro Ala Ala Gly Pro Gly Pro 
                85                  90                  95      


Gly Asp Thr Val Leu Leu Leu Gly Gly Ala Gly Leu Pro Leu Ala Glu 
            100                 105                 110         


Arg Leu Ala Arg Arg Leu Ala Glu Arg Gly Ala Arg Val Val Lys Val 
        115                 120                 125             


Ala Ala Ala Glu Gly Phe Arg Asp Asp Gly Gly Gly Gly Phe Ala Leu 
    130                 135                 140                 


Arg Pro Glu Glu Arg Ala Asp His Ala Ala Leu Trp Arg Ala Leu Gly 
145                 150                 155                 160 


Pro Thr His Ala Phe His Cys Trp Gly Leu Glu Glu Asp Trp Glu Gln 
                165                 170                 175     


Gly Tyr Phe Ser Leu Leu Ala Leu Val Gln Gly Arg Glu Asp Ala Gly 
            180                 185                 190         


Arg Asp Gly Pro Leu Ser Leu Thr Ile Val Ile Asp Arg Ala Glu Glu 
        195                 200                 205             


Val Ala Gly Asn Glu Pro Leu Glu Pro Gly Arg Ala Thr Val Ala Ala 
    210                 215                 220                 


Leu Ala Arg Val Leu Gly Gln Glu Met Pro Arg Ile Ala Cys Arg Asp 
225                 230                 235                 240 


Val Leu Val Pro Asn Ala Gly Ser Ala Ala Glu Ala Gln Leu Ala Glu 
                245                 250                 255     


Ala Leu Ala Gly Glu Pro Ala Arg Pro Val Asp Glu Phe Cys Val Ala 
            260                 265                 270         


Trp Arg Gly Ala Gln Arg Trp Val Lys Thr Tyr Glu Pro Val Pro Ala 
        275                 280                 285             


Pro Ala Ala Cys Ala Gln Arg Leu Arg Gln Gly Ser 
    290                 295                 300 


<210>  85
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AT-KR

<400>  85

Ala Asp His Arg Gln Ile Thr Glu Ala Val Ala Asp Ala Tyr Val Leu 
1               5                   10                  15      


Gly His Leu Pro Asp Phe Ala Ala Leu Arg Arg Pro His Ala Arg Lys 
            20                  25                  30          


Leu Asp Leu Pro Thr Tyr Pro Phe Glu Arg Arg Gln Tyr Trp Phe Arg 
        35                  40                  45              


Asp Ala Arg Glu Arg Pro Glu Gln Pro Arg Asp Thr Gly Gly Pro Arg 
    50                  55                  60                  


Thr Glu Ala Val Arg Leu Leu Glu Asp Gly Arg Ile Glu Glu Leu Ala 
65                  70                  75                  80  


Ala Leu Leu Gly Gly Ala Ser Asp Asp Gln His Thr Leu Gln Val Leu 
                85                  90                  95      


Thr Lys Leu Ala Ala Gln His Asn Gln Gln Arg Thr Thr Arg Ser Ile 
            100                 105                 110         


Ala Asp Asp Arg Tyr Glu Ile Arg Trp Asp Arg Ser Thr Ser Pro Leu 
        115                 120                 125             


Ser Gly Ala Asp Val Asp Gln Ala Gly Ser Trp Ile Val Val Ser Asp 
    130                 135                 140                 


Asp Ala Asp Ala Val Pro Pro Leu Val Asp Leu Leu Ala Ala Arg Asn 
145                 150                 155                 160 


Glu Pro His Gln Val Val Gly Leu Pro Ala Ser Asp Ala Asp Glu Glu 
                165                 170                 175     


Arg Leu Ala Glu Thr Leu Arg Ala Ala Ala Thr Glu Asp Ala Thr Leu 
            180                 185                 190         


Arg Ile Val His Val Ala Ala Leu Glu Ala Gly Ala Thr Pro Ser Met 
        195                 200                 205             


Arg Ser Leu Leu Arg Met Gln His Arg Ile Leu Gly Gly Thr Arg Arg 
    210                 215                 220                 


Val Phe Arg Ala Ala Val Ala Ala Glu Leu Arg Gly Pro Ile Trp Ile 
225                 230                 235                 240 


Val Thr Arg Gly Ala Gln Arg Val Ala Asp Thr Asp Thr Val Ala Pro 
                245                 250                 255     


His Gln Ser Cys Leu Trp Gly Phe Gly Arg Ala Ala Ser Leu Glu Leu 
            260                 265                 270         


Pro His Val Trp Gly Gly Leu Ala Asp Leu Ser Glu Gly Gly Asp Asn 
        275                 280                 285             


Ala Ala Asp Glu Trp Ser Ala Leu Val Asp Arg Ile Ala Ala Pro His 
    290                 295                 300                 


Gly Ser Ala Val Arg Glu Asp Gln Leu Ala Leu Arg Asp Arg Ala Val 
305                 310                 315                 320 


Tyr Thr Pro Arg Leu Ala Arg Arg Ser Ala Pro Pro Ser Gly Thr Pro 
                325                 330                 335     


Leu His Leu Arg Gly Asp 
            340         


<210>  86
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Condensation A

<400>  86

Thr Thr Ser Phe Ile Glu His Leu Gln His Thr Lys Gln Thr Leu Ile 
1               5                   10                  15      


Asp Ala Phe Arg His Gln Ser Tyr Thr Leu Glu Asp Leu Leu Ala Ala 
            20                  25                  30          


Leu Gln Leu Pro Arg Asp Phe Ser Arg Ser Pro Leu Ile Ser Val Ser 
        35                  40                  45              


Phe Asn Met Asp Pro Ser Leu Thr Leu Pro Glu Phe Lys Asp Leu Lys 
    50                  55                  60                  


Val Ser Leu Pro Pro Ser Pro Ile Ser Tyr Thr Pro Phe Asp Leu Gly 
65                  70                  75                  80  


Phe Asn Leu Ile Glu Leu Asn Asp Asn Leu Ile Ile Tyr Cys Asn Tyr 
                85                  90                  95      


Asn Thr Glu Leu Phe Lys Lys Glu Thr Ile Lys Gln Phe Leu Glu Ser 
            100                 105                 110         


Phe Glu Ile Leu Leu Arg Gly Ile Ile Asp Asp Ala Asn His Leu Leu 
        115                 120                 125             


Tyr Gln Leu Pro Leu Leu Thr Pro Val Gln Gln Glu Lys Leu Leu Arg 
    130                 135                 140                 


Gln Leu Thr Gly Lys Thr Arg Lys Leu Pro Glu Lys Ala Thr Ile Ile 
145                 150                 155                 160 


Asp Asp Phe Val Ala Gln Val Lys Leu Thr Pro Asn Ala Pro Ala Leu 
                165                 170                 175     


Ile Ala Gly Lys Ile Ser Leu 
            180             


<210>  87
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DH-ER

<400>  87
gttgcatacg ttgcagaaga cgcaacggcc acgatgctgg cagaggttgc cctgccgggg       60

agcatacgta gccagcaggg tctgtacgca atacacccgg ccctgctgga tgcatgtttc      120

caatcggttg gtgcccaccc agatagccaa agcgttggga gcggtttact ggttccgctg      180

ggggttcgtc gtgttcgggc ctacgccccg gttcgtaccg cacggtactg ttacacccgt      240

gttacgaaag ttgagctggc aggtgttgag gccgatatag atgttctgga tgcccacggt      300

acggttctgt tagccgtttg tggtctgcgt ataggtacgg gtgttagcga acgtgataag      360

cacaatcgtg ttctgaatga gcgtttactg acgatcgaat ggcaccagcg ggaactgccg      420

gagatggatc caagcggtgc aggtaagtgg ctgctgatct cggactgtgc cgccagcgac      480

gttacggcaa cgcgtttagc cgacgccttc cgtgaacaca gcgcagcatg tacgacgatg      540

cgttggccac tgcacgatga ccagttagcc gccgccgatc agttacgtga tcaggttggg      600

agcgacgaat tctcgggggt tgttgttctg accgggccga atacgggtac gccgcaccaa      660

gggagcgccg atcggggtgc cgaatacgtt cgtcggctgg ttggtatcgc ccgtgagctg      720

agcgacttac cgggtgccgt tccgcggatg tacgttgtta cccgtggtgc ccaacgtgtt      780

ctggcagacg actgtgttaa tttagaacag ggtgggctgc gtgggctgct gcggacgatc      840

ggtgccgaac acccgcactt acgtgccacg cagatcgatg ttgacgagca gacgggtgtt      900

gagcagttag cccgtcagct gttagccacg agcgaagaag acgaaacggc atggcgggat      960

aatgaatggt acgttgcccg tttatgtccg accccactgc gtccacagga acggcgtacg     1020

atcgttgccg atcaccagca aagcgggatg cgtctgcaaa tacgtacccc g              1071


<210>  88
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DH-ER

<400>  88

Ala Ala Trp His Val Asp Gly Asp Val Trp Ala Arg Val Ala Leu Pro 
1               5                   10                  15      


Glu Ala Ala Ala Ser Ser Ala Ile Arg Tyr Gly Leu His Pro Ala Leu 
            20                  25                  30          


Leu Asp Ser Ser Met His Ser Leu Leu Leu Thr Gln Arg Leu Lys Ala 
        35                  40                  45              


Gln Val Gly Asp Asp Val Phe Val Pro Phe Glu Ala Glu Arg Leu Ser 
    50                  55                  60                  


Val Trp Lys Asp Gly Leu Ala Glu Val Trp Val Lys Val Ala Glu Phe 
65                  70                  75                  80  


Glu Leu Gly Glu Gly Glu Phe Trp Ala Ser Leu Asp Leu Tyr Asp Thr 
                85                  90                  95      


Ser Gly Glu His Val Gly Arg Leu Gln Arg Leu His Ala Arg Arg Ile 
            100                 105                 110         


Asp Arg Ala Ala Leu Arg Arg Leu Ala Ala Ala Gly Val Asp Arg Phe 
        115                 120                 125             


Leu Phe Arg Thr Glu Trp Gln Pro Val Glu Ala Pro Glu Ala Val Phe 
    130                 135                 140                 


Gly Gly Thr Trp Gly Leu Leu Gly Gly Ala Asp Ala Pro Trp Ala Asp 
145                 150                 155                 160 


Glu Val Arg Ser Arg Leu Met Gln Ala Gly Ala Gln Val Val Asp Ile 
                165                 170                 175     


Ala Arg Leu Ser Glu Ala Glu Ala Cys Asp Gly Val Ile Gln Leu Trp 
            180                 185                 190         


Gly Gly Asp Gly Gln Val Val Glu Ser Ser His Arg Gln Ala Ala Ser 
        195                 200                 205             


Ala Leu Val Gln Val Gln Glu Leu Ala Leu Ala Gly Phe Ala Lys Pro 
    210                 215                 220                 


Val Ile Trp Leu Thr Arg Gly Ala Val Gly Thr Ser Ser Asp Asp Pro 
225                 230                 235                 240 


Val Ser Asp Leu Gly Ala Ser Pro Leu Trp Gly Leu Leu Arg Thr Ala 
                245                 250                 255     


Arg Asn Glu His Pro Glu Leu Ala Leu Arg Ile Val Asp Leu Gly Asp 
            260                 265                 270         


Thr Ala Ala Asp Leu Asp Thr Leu Ala Ser Ala Leu Ala Leu Ala Asp 
        275                 280                 285             


Glu Pro Glu Cys Ala Leu Arg Gly Ala Lys Val Leu Ala Pro Arg Leu 
    290                 295                 300                 


Lys Lys Ala Pro Ala Asn Ala Gly Leu Val Leu Pro Ala Glu Gly Asn 
305                 310                 315                 320 


Trp Arg Leu Glu Ile Ala Thr Lys Gly Arg Leu Asp Gln Pro Leu Ser 
                325                 330                 335     


<210>  89
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DH-ER

<400>  89

Val Ala Tyr Val Ala Glu Asp Ala Thr Ala Thr Met Leu Ala Glu Val 
1               5                   10                  15      


Ala Leu Pro Gly Ser Ile Arg Ser Gln Gln Gly Leu Tyr Ala Ile His 
            20                  25                  30          


Pro Ala Leu Leu Asp Ala Cys Phe Gln Ser Val Gly Ala His Pro Asp 
        35                  40                  45              


Ser Gln Ser Val Gly Ser Gly Leu Leu Val Pro Leu Gly Val Arg Arg 
    50                  55                  60                  


Val Arg Ala Tyr Ala Pro Val Arg Thr Ala Arg Tyr Cys Tyr Thr Arg 
65                  70                  75                  80  


Val Thr Lys Val Glu Leu Ala Gly Val Glu Ala Asp Ile Asp Val Leu 
                85                  90                  95      


Asp Ala His Gly Thr Val Leu Leu Ala Val Cys Gly Leu Arg Ile Gly 
            100                 105                 110         


Thr Gly Val Ser Glu Arg Asp Lys His Asn Arg Val Leu Asn Glu Arg 
        115                 120                 125             


Leu Leu Thr Ile Glu Trp His Gln Arg Glu Leu Pro Glu Met Asp Pro 
    130                 135                 140                 


Ser Gly Ala Gly Lys Trp Leu Leu Ile Ser Asp Cys Ala Ala Ser Asp 
145                 150                 155                 160 


Val Thr Ala Thr Arg Leu Ala Asp Ala Phe Arg Glu His Ser Ala Ala 
                165                 170                 175     


Cys Thr Thr Met Arg Trp Pro Leu His Asp Asp Gln Leu Ala Ala Ala 
            180                 185                 190         


Asp Gln Leu Arg Asp Gln Val Gly Ser Asp Glu Phe Ser Gly Val Val 
        195                 200                 205             


Val Leu Thr Gly Pro Asn Thr Gly Thr Pro His Gln Gly Ser Ala Asp 
    210                 215                 220                 


Arg Gly Ala Glu Tyr Val Arg Arg Leu Val Gly Ile Ala Arg Glu Leu 
225                 230                 235                 240 


Ser Asp Leu Pro Gly Ala Val Pro Arg Met Tyr Val Val Thr Arg Gly 
                245                 250                 255     


Ala Gln Arg Val Leu Ala Asp Asp Cys Val Asn Leu Glu Gln Gly Gly 
            260                 265                 270         


Leu Arg Gly Leu Leu Arg Thr Ile Gly Ala Glu His Pro His Leu Arg 
        275                 280                 285             


Ala Thr Gln Ile Asp Val Asp Glu Gln Thr Gly Val Glu Gln Leu Ala 
    290                 295                 300                 


Arg Gln Leu Leu Ala Thr Ser Glu Glu Asp Glu Thr Ala Trp Arg Asp 
305                 310                 315                 320 


Asn Glu Trp Tyr Val Ala Arg Leu Cys Pro Thr Pro Leu Arg Pro Gln 
                325                 330                 335     


Glu Arg Arg Thr Ile Val Ala Asp His Gln Gln Ser Gly Met Arg Leu 
            340                 345                 350         


Gln Ile Arg Thr Pro 
        355         


<210>  90
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DH-KR

<400>  90

Ala Ala Trp Arg Gln Gly Asp Val Val Tyr Ala Asp Val Arg Leu Pro 
1               5                   10                  15      


Val Pro Asp Gly Ala Glu Gly Leu His Pro Ala Leu Leu Asp Ala Ala 
            20                  25                  30          


Leu His Pro Ala Arg Leu Leu Asp Asp Arg Asp Arg Thr Pro Arg Met 
        35                  40                  45              


Pro Phe Leu Trp Ala Gly Val His Arg Tyr Asp Gly Gly Ala Thr Gln 
    50                  55                  60                  


Ala Arg Val Arg Ile Met Arg Ala Gly Gly His Ser Ala Glu Gln Ile 
65                  70                  75                  80  


Ala Val Gln Leu Ala Gly Pro Asp Gly Arg Ala Leu Phe Glu Val Glu 
                85                  90                  95      


Ala Leu Thr Val Arg Pro Val Pro Arg Ser Val His Gln Pro Thr Trp 
            100                 105                 110         


Val Thr Val Thr Pro Pro Ala Thr Val Pro Val Glu Pro Gly Val Leu 
        115                 120                 125             


Asp Leu Ser Gly Pro Pro Ala His Ser Pro Glu Glu Val Arg Asp Gln 
    130                 135                 140                 


Val Trp Glu Ala Ala Glu Lys Leu Arg Ser Arg Leu Pro Gly Pro Arg 
145                 150                 155                 160 


Ile Val Val Val Thr Arg Ser Ala Ala Val Ala Gly Leu Ile Arg Val 
                165                 170                 175     


Ala Ile Thr Glu Tyr Pro Gly Gln Val Ala Leu Val Glu Trp Asp Gly 
            180                 185                 190         


Gly Ala Ala Ser Asp His Val Leu Pro Ala Ala Ile Arg Ala Ala Ala 
        195                 200                 205             


Thr Ala Pro Glu Ile Arg Ile Ala Asp Gly Arg Ile Gly Ser Pro Arg 
    210                 215                 220                 


Leu Val Arg Ala Ala Ile Ala Gly Pro Gly Thr Gly Gly Phe Gly Asp 
225                 230                 235                 240 


<210>  91
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dual Condensation A

<400>  91

Ala Ala Trp His Val Asp Gly Asp Val Trp Ala Arg Val Ala Leu Pro 
1               5                   10                  15      


Glu Ala Ala Ala Ser Ser Ala Ile Arg Tyr Gly Leu His Pro Ala Leu 
            20                  25                  30          


Leu Asp Ser Ser Met His Ser Leu Leu Leu Thr Gln Arg Leu Lys Ala 
        35                  40                  45              


Gln Val Gly Asp Asp Val Phe Val Pro Phe Glu Ala Glu Arg Leu Ser 
    50                  55                  60                  


Val Lys Asp Gly Leu Ala Glu Val Trp Val Lys Val Ala Glu Phe Glu 
65                  70                  75                  80  


Leu Gly Glu Gly Glu Phe Trp Ala Ser Leu Asp Leu Tyr Asp Thr Ser 
                85                  90                  95      


Gly Glu His Val Gly Arg Leu Gln Arg Leu His Ala Arg Arg Ile Asp 
            100                 105                 110         


Arg Ala Ala Leu Arg Arg Leu Ala Ala Ala Gly Val Asp Arg Phe Leu 
        115                 120                 125             


Phe Arg Thr Glu Trp Gln Pro Val Glu Ala Pro Glu Ala Val Phe Gly 
    130                 135                 140                 


Gly Thr Trp Gly Leu Leu Gly Gly Ala Asp Ala Pro Trp Ala Asp Glu 
145                 150                 155                 160 


Val Arg Ser Arg Leu Met Gln Ala Gly Ala Gln Val Val Asp Ile Ala 
                165                 170                 175     


Arg Leu Ser Glu Ala Glu Ala Cys Asp Gly Val Ile Gln Leu Trp Gly 
            180                 185                 190         


Gly Asp Gly Gln Val Val Glu Ser Ser His Arg Gln Ala Ala Ser Ala 
        195                 200                 205             


Leu Val Gln Val Gln Glu Leu Ala Leu Ala Gly Phe Ala Lys Pro Val 
    210                 215                 220                 


Ile Trp Leu Thr Arg Gly Ala Val Gly Thr Ser Ser Asp Asp Pro Val 
225                 230                 235                 240 


Ser Asp Leu Gly Ala Ser Pro Leu Trp Gly Leu Leu Arg Thr Ala Arg 
                245                 250                 255     


Asn Glu His Pro Glu Leu Ala Leu Arg Ile Val Asp Leu Gly Asp Thr 
            260                 265                 270         


Ala Ala Asp Leu Asp Thr Leu Ala Ser Ala Leu Ala Leu Ala Asp Glu 
        275                 280                 285             


Pro Glu Cys Ala Leu Arg Gly Ala Lys Val Leu Ala Pro Arg Leu Lys 
    290                 295                 300                 


Lys Ala Pro Ala Asn Ala Gly Leu Val Leu Pro Ala Glu Gly Asn Trp 
305                 310                 315                 320 


Arg Leu Glu Ile Ala Thr Lys Gly Arg Leu Asp Gln Pro Leu Ser 
                325                 330                 335 


<210>  92
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER-KR

<400>  92
ataccgcaga ccggtaaatc gctggttacg ttaccgccgg aacaagccca ggttttccgg       60

ccggat                                                                  66


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER-KR

<400>  93

Pro Thr Gln Arg Arg Gly Met Val Asp Pro Asp 
1               5                   10      


<210>  94
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER-KR

<400>  94

Ile Pro Gln Thr Gly Lys Ser Leu Val Thr Leu Pro Pro Glu Gln Ala 
1               5                   10                  15      


Gln Val Phe Arg Pro Asp 
            20          


<210>  95
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterocyclization A

<400>  95

Pro Val Ala Ala Phe Gly Glu Arg Leu Ala Thr Leu His Gly Arg Leu 
1               5                   10                  15      


Trp Gln Asp Leu Asp His Arg Leu Cys Gly Gly Val Glu Val Leu Arg 
            20                  25                  30          


Glu Ile Ala Arg Arg Arg Gly Arg Ala Ala Ala Ala Leu Pro Val Thr 
        35                  40                  45              


Phe Thr Ser Thr Val Ser Gly Ala Pro Thr Pro Gly Ala Gly Leu Met 
    50                  55                  60                  


Pro Gly Ala Arg Leu Arg Tyr Gly Ile Ser Gln Thr Pro Gln Val Trp 
65                  70                  75                  80  


Ile Asp Cys Gln Met Met Ala Glu Asp Gly Gly Leu Leu Leu His Trp 
                85                  90                  95      


Asp Val Arg Asp Gly Val Leu Pro Asp Gly Val Ala Ala Asp Met Phe 
            100                 105                 110         


Ala Ala Phe Thr Glu Leu Val Glu Arg Leu Ala Asp Gly Asp Ala Val 
        115                 120                 125             


Asp Glu Ala Asp Pro Val Val Leu Pro Arg Arg Gln Arg Glu Leu Val 
    130                 135                 140                 


Ala Ala Ala Asn Asp Thr Ala Glu Pro Arg Val Arg Gly Pro Leu His 
145                 150                 155                 160 


Ala Ala Phe Leu Asp Arg Ala Arg Arg Asp Pro Gly Arg Val Ala Val 
                165                 170                 175     


Ile Ala Ala Gly Cys Thr Leu 
            180             


<210>  96
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Joint AC-PC

<400>  96

Leu Gly Thr Asp Ser Lys Leu Pro Gly Gly Arg Arg Gly Thr Ser Asp 
1               5                   10                  15      


Glu Pro 
        


<210>  97
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KR-ACP

<400>  97
atcgggcgtg ccatcgcctt cgcagaacaa acgggtgacg ccatcgcacc ggaggaaggg       60

gcctacgcct tcgaaacgtt actgcgtcac aatcgtgcat actcgggtta cgcaccagtg      120

atcggttcgc cgtggttaac ggccttcgcc cagcacagcc cattcgccga aaaattccaa      180

tcgctggggc agaatcggag cggtaccagc aagttcctgg ccgaattagt tgatctgccg      240

cgggaagaat ggccggaccg gctgcgtcgt ctgtta                                276


<210>  98
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KR-ACP

<400>  98

Gln Gly Met Ala Ala Arg Leu Ser Asp Ala Asp Lys Thr Arg Phe Ser 
1               5                   10                  15      


Arg Gln Gly Met Glu Ala Leu Gly Pro Thr Glu Ala Leu Asp Leu Phe 
            20                  25                  30          


Glu Ala Ala Val Met Ser Asp Ala Pro Met Ala Val Ala Ala Ala Leu 
        35                  40                  45              


Asp Leu Gly Arg Leu Gln Arg Thr Leu Glu Asp Asn Asn Gly Gly Ser 
    50                  55                  60                  


Ala Pro Ala Leu Tyr Arg Glu Leu Phe Ser Arg Ala Ala Gly Gly Arg 
65                  70                  75                  80  


Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly Leu Arg Lys Leu Leu 
                85                  90                  95      


Val Glu Thr Ala Val Glu Gln Arg Glu Ala Ala Val Leu 
            100                 105                 


<210>  99
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KR-ACP

<400>  99

Ile Gly Arg Ala Ile Ala Phe Ala Glu Gln Thr Gly Asp Ala Ile Ala 
1               5                   10                  15      


Pro Glu Glu Gly Ala Tyr Ala Phe Glu Thr Leu Leu Arg His Asn Arg 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Ala Pro Val Ile Gly Ser Pro Trp Leu Thr Ala 
        35                  40                  45              


Phe Ala Gln His Ser Pro Phe Ala Glu Lys Phe Gln Ser Leu Gly Gln 
    50                  55                  60                  


Asn Arg Ser Gly Thr Ser Lys Phe Leu Ala Glu Leu Val Asp Leu Pro 
65                  70                  75                  80  


Arg Glu Glu Trp Pro Asp Arg Leu Arg Arg Leu Leu 
                85                  90          


<210>  100
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KS-AT

<400>  100
caggaagttc ggccggcccc ggggcagggt ctgtcgccag ccgttagcac cttagttgtt       60

gccggtaaaa cgatgcagcg tgtttcggca accgcaggga tgctggccga ttggatggag      120

ggtccggggg ccgatgttgc actggcagac gttgcccaca cgctgaatca ccaccggagc      180

cgtcaaccga agttcggtac cgttgttgca cgtgaccgga cccaggccat cgccggttta      240

cgtgccctgg ccgccggtca acacgcccca ggtgttgtta atccggcaga agggagcccg      300

gggccgggga cggttttc                                                    318


<210>  101
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KS-AT

<400>  101

Gln Glu Val Arg Pro Ala Pro Gly Gln Gly Leu Ser Pro Ala Val Ser 
1               5                   10                  15      


Thr Leu Val Val Ala Gly Lys Thr Met Gln Arg Val Ser Ala Thr Ala 
            20                  25                  30          


Gly Met Leu Ala Asp Trp Met Glu Gly Pro Gly Ala Asp Val Ala Leu 
        35                  40                  45              


Ala Asp Val Ala His Thr Leu Asn His His Arg Ser Arg Gln Pro Lys 
    50                  55                  60                  


Phe Gly Thr Val Val Ala Arg Asp Arg Thr Gln Ala Ile Ala Gly Leu 
65                  70                  75                  80  


Arg Ala Leu Ala Ala Gly Gln His Ala Pro Gly Val Val Asn Pro Ala 
                85                  90                  95      


Glu Gly Ser Pro Gly Pro Gly Thr Val Phe 
            100                 105    
             


<210>  102
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KS-AT

<400>  102

Lys Ala Ala Ala Pro Ala Arg Ala Ala Lys Pro Ala Ala Thr Pro Glu 
1               5                   10                  15      


Ser Leu Pro Phe Val Leu Ser Ala Phe Thr Val Pro Ala Leu Arg Ala 
            20                  25                  30          


Gln Ala Asp Lys Leu His Leu His Met Gly Met Asn Ile Gln Asp Arg 
        35                  40                  45              


Phe Leu Asp Val Ala Tyr Ser Leu Ala Thr Thr Arg Thr His Phe Arg 
    50                  55                  60                  


Lys Arg Leu Val Val Phe Ala Lys Gly Lys Ser Asp Leu Leu Asp Ala 
65                  70                  75                  80  


Leu Ala Ser Tyr Gly Arg Thr Gly Glu Val Pro Ala Gly Ala Val Ser 
                85                  90                  95      


Met Val Asp Asp Arg Asp Glu Cys Arg Leu Ala Leu 
            100                 105


<210>  103
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved Motif KS-AT

<400>  103

Ala Glu Ala Gly Pro Glu Pro Glu Arg Gly Pro Val Pro Ala Val Ser 
1               5                   10                  15      


Thr Leu Val Val Phe Gly Lys Thr Ala Gln Arg Val Ala Ala Thr Ala 
            20                  25                  30          


Ser Val Leu Ala Asp Trp Met Glu Gly Pro Gly Ala Glu Val Ala Leu 
        35                  40                  45              


Ala Asp Val Ala His Thr Leu Asn His His Arg Ala Arg Gln Thr Arg 
    50                  55                  60                  


Phe Gly Thr Val Val Ala Arg Asp Arg Ala Gln Ala Ile Ala Gly Leu 
65                  70                  75                  80  


Arg Ala Leu Ala Ala Gly Gln His Ala Pro Gly Val Val Ala Pro Arg 
                85                  90                  95      


Glu Gly Ser Pro 
            100 


<210>  104
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved Motif KS-AT

<400>  104

Leu Ala Asp Val Ala His Thr Leu Asn His His Arg Ala Arg His Ala 
1               5                   10                  15      


Lys Phe Ala Thr Val Cys Ala Arg Asp Arg Ala Gln 
            20                  25              


<210>  105
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved Motif KS-AT

<400>  105

Pro Ala Val Ser Thr Leu Val Val Ser Gly Lys Thr Pro Glu Arg Ile 
1               5                   10                  15      


Ala Ser Thr Ala Gly Ala Leu Ala Asp Trp Leu Ala Gly Pro Gly 
            20                  25                  30      


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved Motif KS-AT

<400>  106

Pro Gly Thr Val Phe 
1               5   


<210>  107
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved Motif KS-AT

<400>  107

Ala Val Ala Gly Leu Arg Ala Leu Ala Ala Gly Gln Pro Ala Pro Gly 
1               5                   10                  15      


Val Val Gly Pro His Asp 
            20          


<210>  108
<211>  12939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-MalOH

<400>  108
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac ctggaattgg ggcgctagtt     7680

cccgctcccg tggtaatcgc agcaggccgt acggaggaac caattgccat cgtttcgatg     7740

gcatgtcgtt taccgggagg agtcaatacg ccccaacggc tctgggaatt actacgggag     7800

ggtggtgaaa ccttgtccgg gttcccaacg gaccgtggct gggacctagc acggcttcac     7860

caccctgatc cggacaaccc cggaacgagc tacgttgata agggtggatt tctcgacgac     7920

gcggcgggtt tcgacgcaga gtttttcggg gtttcaccaa gggaagctgc cgctatggac     7980

cctcagcaac gattactttt agagacctcg tgggagctag ttgaaaatgc gggcatagat     8040

ccacatagcc tgcgagggac agcgacaggg gtgttcctag gagttgcgaa gtttggttat     8100

ggtgaggaca cagcagcagc ggaagatgtt gaaggttatt cagttaccgg tgttgctccc     8160

gctgtggcat ctggccgcat atcctacact atgggtttag aaggtccttc catctcggtc     8220

gataccgcat gctcaagctc gctagtcgcg cttcatctag ccgtagagtc cctccgaaag     8280

ggtgagtcat ctatggcggt ggtgggtggt gcagccgtta tggcgactcc tggggtattt     8340

gttgattttt cacgccaacg ggcgcttgcc gcagacggcc gttccaaagc gttcggggca     8400

ggtgcagatg gttttggttt cagcgaggga gtcacgctgg ttctactaga gcgtttaagt     8460

gaggcgcgtc gtaacggtca tgaagttcta gctgtagtgc gcgggtccgc gttaaaccag     8520

gacggagcga gcaacggact ttcagcaccc tccggccctg cgcaacgtag agtaataagg     8580

caagcgctcg aatcgtgtgg gcttgaaccg ggggatgttg acgcggttga ggcgcatggt     8640

actggtacag cactaggtga cccaatagag gccaatgcgc tgttggacac ttacgggcga     8700

gaccgtgatg cggatcgtcc actttggttg gggtccgtta agagcaatat tgggcacact     8760

caagctgcgg ccggggttac aggactgctg aaggttgtgt tagcactgcg caatggtgag     8820

ctacctgcaa cgttacatgt cgaggaacca actccacacg tcgattggtc ctcaggtggt     8880

gtcgcattac tggcgggtaa tcaaccatgg cgaaggggag aaaggaccag aagggcggca     8940

gtgagcgcct ttggtatctc cggtacaaat gctcacgtga tagtggaaga ggcgcctcag     9000

gaagttcgac ccgcccctgg ccaagggctg tcgccagccg tgtccacgtt agttgttgca     9060

ggtaaaacca tgcagcgtgt aagtgcgaca gctggaatgc ttgcagactg gatggagggt     9120

cctggggccg atgttgcatt ggcggatgtg gcccataccc tgaaccatca ccgatcaaga     9180

cagcccaagt tcgggacggt tgtagcgcgt gacaggactc aggcgatagc tgggctccgt     9240

gcattggcgg ctggtcaaca tgctcctggg gtcgtcaacc cagctgaagg ttccccagga     9300

ccaggcaccg tgttcgtttt tcccggtcaa ggttcgcaga gggcagggat gggggaggaa     9360

ctcgcggcag cctttcctgt cttcgctcga atacatcagc aagtttggga cctcctagat     9420

gttcccgacc tcgacgttaa tgaaaccggg tacgcccaac cagcgctgtt cgcgcttcag     9480

gtcgcgctct ttggccttct ggagtcgtgg ggtgttaggc cagatgcagt ggtagggcac     9540

tcagttggtg agctggccgc ggggtacgtg tccggtcttt ggtcactaga ggacgcctgc     9600

acactagtct cagcaagagc gcgcctaatg caggcactgc ctgctggagg ggtgatggcg     9660

gcagtccccg tctccgagga tgaggcgcgg gccgtcctgg gcgagggagt tgaaattgcg     9720

gctgtgaatg gaccctcgtc cgttgtgctc tcaggggacg aggcggcagt cttacaggcc     9780

gccgaaggtc taggtaagtg gacgcgactg ccgaccagcc atgcttttca ctcagcgaga     9840

atggaaccca tgctagaaga gtttcgggcc gtagcagagg gtctgaccta tcgtacccct     9900

caagtagcta tggctgctgg ggatcaggtg atgacagcag aatattgggt gcggcaggtt     9960

cgggacacag ttcgcttcgg ggagcaagta gcgtcattcg aggatgcggt gtttgttgag    10020

ttaggcgctg acagaagtct agcgcgtttg gtggacggca tcgccatgct gcacggtgac    10080

cacgaagcgc aggccgcgga ccataggcaa atcaccgaag cggttgcgga tgcttacgtc    10140

ttaggccacc ttccggattt tgcggcgctg cggcggcctc acgcacgaaa gttggactta    10200

ccaacttatc ccttcgagcg tagacagtac tggttcagag atgcgcgtga gaggccggaa    10260

caacccagag ataccggcgg acctcgcaca gaagcagtcc gtctgttaga ggatggtagg    10320

attgaagaat tagctgcact tttgggaggg gccagtgatg accaacacac attacaggtg    10380

ctgactaagt tggcggcgca acataaccaa caacgaacaa cccggtcaat cgctgacgac    10440

aggtacgaaa taaggtggga ccgatcgact tccccactat ccggagcaga tgttgaccaa    10500

gcggggagct ggatcgtggt gtcagatgac gcagatgccg ttcccccgct agtggacttg    10560

ctggctgcac gtaacgagcc ccatcaggtt gttggtctac ccgcttcgga cgcagacgag    10620

gagaggctcg cagagactct gcgtgcggct gcgactgaag atgctaccct tcggatagtc    10680

cacgttgcgg cgctcgaagc aggcgctacc cccagcatgc gttcactgct ccgcatgcag    10740

caccgaatac taggtggcac gcggcgggtg ttcagggcag cggtcgcagc ggagttaaga    10800

ggtcccattt ggatagtgac gcggggagca caaagagtgg ctgacaccga tacagttgcc    10860

ccgcatcagt catgcctctg gggatttggg agggcagcat cgctggagct gccgcacgtt    10920

tggggtggcc tagcagattt atcagagggc ggtgacaatg cggccgatga gtggagtgcg    10980

ctagtggacc gcattgccgc accccacggt tcagcagtta gggaggacca actggcgctg    11040

agagacaggg ccgtatatac gccaagactg gccagacgtt ctgcgccccc gagcgggact    11100

cccctacatc tacgagggga tggcacagtg ttaataacag gtgggactgg tacactaggt    11160

aggctattag cgcgtcacct agtaacagag catggggtgc ggcatctctt actagtttca    11220

aggagaggcg ccgatgcccc tggctcggat gaactgcgcg cagaaataga ggacttaggt    11280

gccagcgcgg agatcgcagc gtgtgataca gcggatcgcg atgccctatc tgccctacta    11340

gatggtctcc cccggcccct tacgggtgtc gttcacgccg ctggcgtgtt agccgatgga    11400

cttgtcacta gcattgacga gcctgcggtg gaacaggttc tccgagcaaa ggtggacgcg    11460

gcatggaacc tacacgaact cacagctaat accgggctat cctttttcgt tcttttctca    11520

tcagcagcat cggtcctggc aggtccaggg caaggagttt atgcggctgc aaatgaatcg    11580

ctcaacgcac tagctgcgtt aaggcgaact aggggtctgc cggccaaggc tctgggatgg    11640

ggcctgtggg ccatcgggcg ggcaatcgct tttgcggagc agaccgggga cgccatcgct    11700

ccagaggaag gagcatacgc ttttgaaact ctgttaaggc ataaccgtgc ctactcggga    11760

tatgcgcccg tcattggatc tccctggttg accgcgttcg cacagcattc cccctttgca    11820

gaaaaattcc aatcactcgg acagaatcgg tcagggacat cgaaattctt agcggagcta    11880

gttgacctgc ctcgtgagga atggccggat aggctcagga gactactaga gttagttagg    11940

tcccatgccg ccgcggtctc cggttacggt agtgcagatc aactgccgga aagaaaagcg    12000

ttcaaggatt tggggtttga ttcgctggcc gccgttgaac tgcgtaaccg gctgggaacg    12060

gctacagggg tacgactgcc gtcaacccta gtatttgatc acccaactcc gctggccgtc    12120

gctgagcact taagagatag gctaacatcc ggggaagata accctatccc cctatgtcaa    12180

ggcgatgggg aggagatgag cacatggcta cgtcgttttg gacccccagt cgaacatcgg    12240

gccaggctag tgtgtttccc ccacgcaggc gcagcggcgg attcatactt agacctagca    12300

agagcgttag caccagagat cgatgttcat gctgttcaat accccggcag gcaagacaga    12360

agggacgagg agccattagg aaccgcaggt gaaattgcag atgaagtggc agcggtgcta    12420

cgtgcgtcgg gaggggatgg gccttttgca cttttcggcc acagtatggg cgccctcatc    12480

gcgtacgaga cagcaaggcg attagagagg gaaccgggag ggggaccctt acgtttattc    12540

gtgagcggac aaacagcgcc acgtgtccat gaacgaagaa ctgatctgcc cggtgacgat    12600

ggactcgtgg acgagcttag gcgacttggc acctccgagg cagcgctcgc agacgaagcc    12660

ctgctggcta tgtctctccc ggtgctcagg gcggattata gggtgttaag atcctacgct    12720

tgggcggatg gtcccccact acgcgccggt ataactgccc tctgcggtga tgcagaccca    12780

ctaactgcaa caggggatgc ggaacgctgg ttacaacatt ccgtgattcc gggtcggaca    12840

cggacatttc ccggtgggca tttttattta ggggaacaag tgaccgaggt ggcaggggct    12900

gtccgtagag atttactgag agcagggtta gcgggttga                           12939


<210>  109
<211>  4312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-MalOH

<400>  109

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro Val Val  Ile Ala Ala 
    2555                 2560                 2565             


Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val Ser Met  Ala Cys Arg 
    2570                 2575                 2580             


Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg Leu Trp  Glu Leu Leu 
    2585                 2590                 2595             


Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe Pro Thr  Asp Arg Gly 
    2600                 2605                 2610             


Trp Asp  Leu Ala Arg Leu His  His Pro Asp Pro Asp  Asn Pro Gly 
    2615                 2620                 2625             


Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu Asp Asp  Ala Ala Gly 
    2630                 2635                 2640             


Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro Arg Glu  Ala Ala Ala 
    2645                 2650                 2655             


Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu Thr Ser  Trp Glu Leu 
    2660                 2665                 2670             


Val Glu  Asn Ala Gly Ile Asp  Pro His Ser Leu Arg  Gly Thr Ala 
    2675                 2680                 2685             


Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe Gly Tyr  Gly Glu Asp 
    2690                 2695                 2700             


Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr Ser Val  Thr Gly Val 
    2705                 2710                 2715             


Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser Tyr Thr  Met Gly Leu 
    2720                 2725                 2730             


Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala Cys Ser  Ser Ser Leu 
    2735                 2740                 2745             


Val Ala  Leu His Leu Ala Val  Glu Ser Leu Arg Lys  Gly Glu Ser 
    2750                 2755                 2760             


Ser Met  Ala Val Val Gly Gly  Ala Ala Val Met Ala  Thr Pro Gly 
    2765                 2770                 2775             


Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala Leu Ala  Ala Asp Gly 
    2780                 2785                 2790             


Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp Gly Phe  Gly Phe Ser 
    2795                 2800                 2805             


Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg Leu Ser  Glu Ala Arg 
    2810                 2815                 2820             


Arg Asn  Gly His Glu Val Leu  Ala Val Val Arg Gly  Ser Ala Leu 
    2825                 2830                 2835             


Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser Ala Pro  Ser Gly Pro 
    2840                 2845                 2850             


Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu Glu Ser  Cys Gly Leu 
    2855                 2860                 2865             


Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala His Gly  Thr Gly Thr 
    2870                 2875                 2880             


Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala Leu Leu  Asp Thr Tyr 
    2885                 2890                 2895             


Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu Trp Leu  Gly Ser Val 
    2900                 2905                 2910             


Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala Ala Gly  Val Thr Gly 
    2915                 2920                 2925             


Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn Gly Glu  Leu Pro Ala 
    2930                 2935                 2940             


Thr Leu  His Val Glu Glu Pro  Thr Pro His Val Asp  Trp Ser Ser 
    2945                 2950                 2955             


Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln Pro Trp  Arg Arg Gly 
    2960                 2965                 2970             


Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala Phe Gly  Ile Ser Gly 
    2975                 2980                 2985             


Thr Asn  Ala His Val Ile Val  Glu Glu Ala Pro Gln  Glu Val Arg 
    2990                 2995                 3000             


Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala Val Ser  Thr Leu Val 
    3005                 3010                 3015             


Val Ala  Gly Lys Thr Met Gln  Arg Val Ser Ala Thr  Ala Gly Met 
    3020                 3025                 3030             


Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala Asp Val  Ala Leu Ala 
    3035                 3040                 3045             


Asp Val  Ala His Thr Leu Asn  His His Arg Ser Arg  Gln Pro Lys 
    3050                 3055                 3060             


Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr Gln Ala  Ile Ala Gly 
    3065                 3070                 3075             


Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala Pro Gly  Val Val Asn 
    3080                 3085                 3090             


Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr Val Phe  Val Phe Pro 
    3095                 3100                 3105             


Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly Glu Glu  Leu Ala Ala 
    3110                 3115                 3120             


Ala Phe  Pro Val Phe Ala Arg  Ile His Gln Gln Val  Trp Asp Leu 
    3125                 3130                 3135             


Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu Thr Gly  Tyr Ala Gln 
    3140                 3145                 3150             


Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu Phe Gly  Leu Leu Glu 
    3155                 3160                 3165             


Ser Trp  Gly Val Arg Pro Asp  Ala Val Val Gly His  Ser Val Gly 
    3170                 3175                 3180             


Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu Trp Ser  Leu Glu Asp 
    3185                 3190                 3195             


Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg Leu Met  Gln Ala Leu 
    3200                 3205                 3210             


Pro Ala  Gly Gly Val Met Ala  Ala Val Pro Val Ser  Glu Asp Glu 
    3215                 3220                 3225             


Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu Ile Ala  Ala Val Asn 
    3230                 3235                 3240             


Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp Glu Ala  Ala Val Leu 
    3245                 3250                 3255             


Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr Arg Leu  Pro Thr Ser 
    3260                 3265                 3270             


His Ala  Phe His Ser Ala Arg  Met Glu Pro Met Leu  Glu Glu Phe 
    3275                 3280                 3285             


Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg Thr Pro  Gln Val Ala 
    3290                 3295                 3300             


Met Ala  Ala Gly Asp Gln Val  Met Thr Ala Glu Tyr  Trp Val Arg 
    3305                 3310                 3315             


Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu Gln Val  Ala Ser Phe 
    3320                 3325                 3330             


Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala Asp Arg  Ser Leu Ala 
    3335                 3340                 3345             


Arg Leu  Val Asp Gly Ile Ala  Met Leu His Gly Asp  His Glu Ala 
    3350                 3355                 3360             


Gln Ala  Ala Asp His Arg Gln  Ile Thr Glu Ala Val  Ala Asp Ala 
    3365                 3370                 3375             


Tyr Val  Leu Gly His Leu Pro  Asp Phe Ala Ala Leu  Arg Arg Pro 
    3380                 3385                 3390             


His Ala  Arg Lys Leu Asp Leu  Pro Thr Tyr Pro Phe  Glu Arg Arg 
    3395                 3400                 3405             


Gln Tyr  Trp Phe Arg Asp Ala  Arg Glu Arg Pro Glu  Gln Pro Arg 
    3410                 3415                 3420             


Asp Thr  Gly Gly Pro Arg Thr  Glu Ala Val Arg Leu  Leu Glu Asp 
    3425                 3430                 3435             


Gly Arg  Ile Glu Glu Leu Ala  Ala Leu Leu Gly Gly  Ala Ser Asp 
    3440                 3445                 3450             


Asp Gln  His Thr Leu Gln Val  Leu Thr Lys Leu Ala  Ala Gln His 
    3455                 3460                 3465             


Asn Gln  Gln Arg Thr Thr Arg  Ser Ile Ala Asp Asp  Arg Tyr Glu 
    3470                 3475                 3480             


Ile Arg  Trp Asp Arg Ser Thr  Ser Pro Leu Ser Gly  Ala Asp Val 
    3485                 3490                 3495             


Asp Gln  Ala Gly Ser Trp Ile  Val Val Ser Asp Asp  Ala Asp Ala 
    3500                 3505                 3510             


Val Pro  Pro Leu Val Asp Leu  Leu Ala Ala Arg Asn  Glu Pro His 
    3515                 3520                 3525             


Gln Val  Val Gly Leu Pro Ala  Ser Asp Ala Asp Glu  Glu Arg Leu 
    3530                 3535                 3540             


Ala Glu  Thr Leu Arg Ala Ala  Ala Thr Glu Asp Ala  Thr Leu Arg 
    3545                 3550                 3555             


Ile Val  His Val Ala Ala Leu  Glu Ala Gly Ala Thr  Pro Ser Met 
    3560                 3565                 3570             


Arg Ser  Leu Leu Arg Met Gln  His Arg Ile Leu Gly  Gly Thr Arg 
    3575                 3580                 3585             


Arg Val  Phe Arg Ala Ala Val  Ala Ala Glu Leu Arg  Gly Pro Ile 
    3590                 3595                 3600             


Trp Ile  Val Thr Arg Gly Ala  Gln Arg Val Ala Asp  Thr Asp Thr 
    3605                 3610                 3615             


Val Ala  Pro His Gln Ser Cys  Leu Trp Gly Phe Gly  Arg Ala Ala 
    3620                 3625                 3630             


Ser Leu  Glu Leu Pro His Val  Trp Gly Gly Leu Ala  Asp Leu Ser 
    3635                 3640                 3645             


Glu Gly  Gly Asp Asn Ala Ala  Asp Glu Trp Ser Ala  Leu Val Asp 
    3650                 3655                 3660             


Arg Ile  Ala Ala Pro His Gly  Ser Ala Val Arg Glu  Asp Gln Leu 
    3665                 3670                 3675             


Ala Leu  Arg Asp Arg Ala Val  Tyr Thr Pro Arg Leu  Ala Arg Arg 
    3680                 3685                 3690             


Ser Ala  Pro Pro Ser Gly Thr  Pro Leu His Leu Arg  Gly Asp Gly 
    3695                 3700                 3705             


Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu 
    3710                 3715                 3720             


Ala Arg  His Leu Val Thr Glu  His Gly Val Arg His  Leu Leu Leu 
    3725                 3730                 3735             


Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg 
    3740                 3745                 3750             


Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys 
    3755                 3760                 3765             


Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu 
    3770                 3775                 3780             


Pro Arg  Pro Leu Thr Gly Val  Val His Ala Ala Gly  Val Leu Ala 
    3785                 3790                 3795             


Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val 
    3800                 3805                 3810             


Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr 
    3815                 3820                 3825             


Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala 
    3830                 3835                 3840             


Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn 
    3845                 3850                 3855             


Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu 
    3860                 3865                 3870             


Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala 
    3875                 3880                 3885             


Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu 
    3890                 3895                 3900             


Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr 
    3905                 3910                 3915             


Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe 
    3920                 3925                 3930             


Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln 
    3935                 3940                 3945             


Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu 
    3950                 3955                 3960             


Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu 
    3965                 3970                 3975             


Val Arg  Ser His Ala Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp 
    3980                 3985                 3990             


Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser 
    3995                 4000                 4005             


Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly 
    4010                 4015                 4020             


Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp His Pro  Thr Pro Leu 
    4025                 4030                 4035             


Ala Val  Ala Glu His Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp 
    4040                 4045                 4050             


Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr 
    4055                 4060                 4065             


Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu His Arg  Ala Arg Leu 
    4070                 4075                 4080             


Val Cys  Phe Pro His Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp 
    4085                 4090                 4095             


Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp Val His  Ala Val Gln 
    4100                 4105                 4110             


Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr 
    4115                 4120                 4125             


Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser 
    4130                 4135                 4140             


Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly His Ser  Met Gly Ala 
    4145                 4150                 4155             


Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly 
    4160                 4165                 4170             


Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg 
    4175                 4180                 4185             


Val His  Glu Arg Arg Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val 
    4190                 4195                 4200             


Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp 
    4205                 4210                 4215             


Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr 
    4220                 4225                 4230             


Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg 
    4235                 4240                 4245             


Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala 
    4250                 4255                 4260             


Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His Ser Val  Ile Pro Gly 
    4265                 4270                 4275             


Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln 
    4280                 4285                 4290             


Val Thr  Glu Val Ala Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala 
    4295                 4300                 4305             


Gly Leu  Ala Gly 
    4310         


<210>  110
<211>  11286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-MalOH

<400>  110
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctacctg gaattggggc gctagttccc gctcccgtgg taatcgcagc aggccgtacg     6060

gaggaaccaa ttgccatcgt ttcgatggca tgtcgtttac cgggaggagt caatacgccc     6120

caacggctct gggaattact acgggagggt ggtgaaacct tgtccgggtt cccaacggac     6180

cgtggctggg acctagcacg gcttcaccac cctgatccgg acaaccccgg aacgagctac     6240

gttgataagg gtggatttct cgacgacgcg gcgggtttcg acgcagagtt tttcggggtt     6300

tcaccaaggg aagctgccgc tatggaccct cagcaacgat tacttttaga gacctcgtgg     6360

gagctagttg aaaatgcggg catagatcca catagcctgc gagggacagc gacaggggtg     6420

ttcctaggag ttgcgaagtt tggttatggt gaggacacag cagcagcgga agatgttgaa     6480

ggttattcag ttaccggtgt tgctcccgct gtggcatctg gccgcatatc ctacactatg     6540

ggtttagaag gtccttccat ctcggtcgat accgcatgct caagctcgct agtcgcgctt     6600

catctagccg tagagtccct ccgaaagggt gagtcatcta tggcggtggt gggtggtgca     6660

gccgttatgg cgactcctgg ggtatttgtt gatttttcac gccaacgggc gcttgccgca     6720

gacggccgtt ccaaagcgtt cggggcaggt gcagatggtt ttggtttcag cgagggagtc     6780

acgctggttc tactagagcg tttaagtgag gcgcgtcgta acggtcatga agttctagct     6840

gtagtgcgcg ggtccgcgtt aaaccaggac ggagcgagca acggactttc agcaccctcc     6900

ggccctgcgc aacgtagagt aataaggcaa gcgctcgaat cgtgtgggct tgaaccgggg     6960

gatgttgacg cggttgaggc gcatggtact ggtacagcac taggtgaccc aatagaggcc     7020

aatgcgctgt tggacactta cgggcgagac cgtgatgcgg atcgtccact ttggttgggg     7080

tccgttaaga gcaatattgg gcacactcaa gctgcggccg gggttacagg actgctgaag     7140

gttgtgttag cactgcgcaa tggtgagcta cctgcaacgt tacatgtcga ggaaccaact     7200

ccacacgtcg attggtcctc aggtggtgtc gcattactgg cgggtaatca accatggcga     7260

aggggagaaa ggaccagaag ggcggcagtg agcgcctttg gtatctccgg tacaaatgct     7320

cacgtgatag tggaagaggc gcctcaggaa gttcgacccg cccctggcca agggctgtcg     7380

ccagccgtgt ccacgttagt tgttgcaggt aaaaccatgc agcgtgtaag tgcgacagct     7440

ggaatgcttg cagactggat ggagggtcct ggggccgatg ttgcattggc ggatgtggcc     7500

cataccctga accatcaccg atcaagacag cccaagttcg ggacggttgt agcgcgtgac     7560

aggactcagg cgatagctgg gctccgtgca ttggcggctg gtcaacatgc tcctggggtc     7620

gtcaacccag ctgaaggttc cccaggacca ggcaccgtgt tcgtttttcc cggtcaaggt     7680

tcgcagaggg cagggatggg ggaggaactc gcggcagcct ttcctgtctt cgctcgaata     7740

catcagcaag tttgggacct cctagatgtt cccgacctcg acgttaatga aaccgggtac     7800

gcccaaccag cgctgttcgc gcttcaggtc gcgctctttg gccttctgga gtcgtggggt     7860

gttaggccag atgcagtggt agggcactca gttggtgagc tggccgcggg gtacgtgtcc     7920

ggtctttggt cactagagga cgcctgcaca ctagtctcag caagagcgcg cctaatgcag     7980

gcactgcctg ctggaggggt gatggcggca gtccccgtct ccgaggatga ggcgcgggcc     8040

gtcctgggcg agggagttga aattgcggct gtgaatggac cctcgtccgt tgtgctctca     8100

ggggacgagg cggcagtctt acaggccgcc gaaggtctag gtaagtggac gcgactgccg     8160

accagccatg cttttcactc agcgagaatg gaacccatgc tagaagagtt tcgggccgta     8220

gcagagggtc tgacctatcg tacccctcaa gtagctatgg ctgctgggga tcaggtgatg     8280

acagcagaat attgggtgcg gcaggttcgg gacacagttc gcttcgggga gcaagtagcg     8340

tcattcgagg atgcggtgtt tgttgagtta ggcgctgaca gaagtctagc gcgtttggtg     8400

gacggcatcg ccatgctgca cggtgaccac gaagcgcagg ccgcggacca taggcaaatc     8460

accgaagcgg ttgcggatgc ttacgtctta ggccaccttc cggattttgc ggcgctgcgg     8520

cggcctcacg cacgaaagtt ggacttacca acttatccct tcgagcgtag acagtactgg     8580

ttcagagatg cgcgtgagag gccggaacaa cccagagata ccggcggacc tcgcacagaa     8640

gcagtccgtc tgttagagga tggtaggatt gaagaattag ctgcactttt gggaggggcc     8700

agtgatgacc aacacacatt acaggtgctg actaagttgg cggcgcaaca taaccaacaa     8760

cgaacaaccc ggtcaatcgc tgacgacagg tacgaaataa ggtgggaccg atcgacttcc     8820

ccactatccg gagcagatgt tgaccaagcg gggagctgga tcgtggtgtc agatgacgca     8880

gatgccgttc ccccgctagt ggacttgctg gctgcacgta acgagcccca tcaggttgtt     8940

ggtctacccg cttcggacgc agacgaggag aggctcgcag agactctgcg tgcggctgcg     9000

actgaagatg ctacccttcg gatagtccac gttgcggcgc tcgaagcagg cgctaccccc     9060

agcatgcgtt cactgctccg catgcagcac cgaatactag gtggcacgcg gcgggtgttc     9120

agggcagcgg tcgcagcgga gttaagaggt cccatttgga tagtgacgcg gggagcacaa     9180

agagtggctg acaccgatac agttgccccg catcagtcat gcctctgggg atttgggagg     9240

gcagcatcgc tggagctgcc gcacgtttgg ggtggcctag cagatttatc agagggcggt     9300

gacaatgcgg ccgatgagtg gagtgcgcta gtggaccgca ttgccgcacc ccacggttca     9360

gcagttaggg aggaccaact ggcgctgaga gacagggccg tatatacgcc aagactggcc     9420

agacgttctg cgcccccgag cgggactccc ctacatctac gaggggatgg cacagtgtta     9480

ataacaggtg ggactggtac actaggtagg ctattagcgc gtcacctagt aacagagcat     9540

ggggtgcggc atctcttact agtttcaagg agaggcgccg atgcccctgg ctcggatgaa     9600

ctgcgcgcag aaatagagga cttaggtgcc agcgcggaga tcgcagcgtg tgatacagcg     9660

gatcgcgatg ccctatctgc cctactagat ggtctccccc ggccccttac gggtgtcgtt     9720

cacgccgctg gcgtgttagc cgatggactt gtcactagca ttgacgagcc tgcggtggaa     9780

caggttctcc gagcaaaggt ggacgcggca tggaacctac acgaactcac agctaatacc     9840

gggctatcct ttttcgttct tttctcatca gcagcatcgg tcctggcagg tccagggcaa     9900

ggagtttatg cggctgcaaa tgaatcgctc aacgcactag ctgcgttaag gcgaactagg     9960

ggtctgccgg ccaaggctct gggatggggc ctgtgggcca tcgggcgggc aatcgctttt    10020

gcggagcaga ccggggacgc catcgctcca gaggaaggag catacgcttt tgaaactctg    10080

ttaaggcata accgtgccta ctcgggatat gcgcccgtca ttggatctcc ctggttgacc    10140

gcgttcgcac agcattcccc ctttgcagaa aaattccaat cactcggaca gaatcggtca    10200

gggacatcga aattcttagc ggagctagtt gacctgcctc gtgaggaatg gccggatagg    10260

ctcaggagac tactagagtt agttaggtcc catgccgccg cggtctccgg ttacggtagt    10320

gcagatcaac tgccggaaag aaaagcgttc aaggatttgg ggtttgattc gctggccgcc    10380

gttgaactgc gtaaccggct gggaacggct acaggggtac gactgccgtc aaccctagta    10440

tttgatcacc caactccgct ggccgtcgct gagcacttaa gagataggct aacatccggg    10500

gaagataacc ctatccccct atgtcaaggc gatggggagg agatgagcac atggctacgt    10560

cgttttggac ccccagtcga acatcgggcc aggctagtgt gtttccccca cgcaggcgca    10620

gcggcggatt catacttaga cctagcaaga gcgttagcac cagagatcga tgttcatgct    10680

gttcaatacc ccggcaggca agacagaagg gacgaggagc cattaggaac cgcaggtgaa    10740

attgcagatg aagtggcagc ggtgctacgt gcgtcgggag gggatgggcc ttttgcactt    10800

ttcggccaca gtatgggcgc cctcatcgcg tacgagacag caaggcgatt agagagggaa    10860

ccgggagggg gacccttacg tttattcgtg agcggacaaa cagcgccacg tgtccatgaa    10920

cgaagaactg atctgcccgg tgacgatgga ctcgtggacg agcttaggcg acttggcacc    10980

tccgaggcag cgctcgcaga cgaagccctg ctggctatgt ctctcccggt gctcagggcg    11040

gattataggg tgttaagatc ctacgcttgg gcggatggtc ccccactacg cgccggtata    11100

actgccctct gcggtgatgc agacccacta actgcaacag gggatgcgga acgctggtta    11160

caacattccg tgattccggg tcggacacgg acatttcccg gtgggcattt ttatttaggg    11220

gaacaagtga ccgaggtggc aggggctgtc cgtagagatt tactgagagc agggttagcg    11280

ggttga                                                               11286


<210>  111
<211>  3761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-MalOH

<400>  111

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    2000                 2005                 2010             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    2015                 2020                 2025             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    2030                 2035                 2040             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    2045                 2050                 2055             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    2060                 2065                 2070             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    2075                 2080                 2085             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    2090                 2095                 2100             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    2105                 2110                 2115             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    2120                 2125                 2130             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    2135                 2140                 2145             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    2150                 2155                 2160             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    2165                 2170                 2175             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    2180                 2185                 2190             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    2195                 2200                 2205             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    2210                 2215                 2220             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    2225                 2230                 2235             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    2240                 2245                 2250             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    2255                 2260                 2265             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    2270                 2275                 2280             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    2285                 2290                 2295             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    2300                 2305                 2310             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2315                 2320                 2325             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2330                 2335                 2340             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2345                 2350                 2355             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2360                 2365                 2370             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2375                 2380                 2385             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2390                 2395                 2400             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2405                 2410                 2415             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2420                 2425                 2430             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2435                 2440                 2445             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2450                 2455                 2460             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2465                 2470                 2475             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2480                 2485                 2490             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2495                 2500                 2505             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2510                 2515                 2520             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2525                 2530                 2535             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2540                 2545                 2550             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2555                 2560                 2565             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2570                 2575                 2580             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2585                 2590                 2595             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2600                 2605                 2610             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2615                 2620                 2625             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2630                 2635                 2640             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2645                 2650                 2655             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2660                 2665                 2670             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2675                 2680                 2685             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2690                 2695                 2700             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2705                 2710                 2715             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2720                 2725                 2730             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2735                 2740                 2745             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2750                 2755                 2760             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2765                 2770                 2775             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2780                 2785                 2790             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2795                 2800                 2805             


Asp His  Glu Ala Gln Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala 
    2810                 2815                 2820             


Val Ala  Asp Ala Tyr Val Leu  Gly His Leu Pro Asp  Phe Ala Ala 
    2825                 2830                 2835             


Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro 
    2840                 2845                 2850             


Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro 
    2855                 2860                 2865             


Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg 
    2870                 2875                 2880             


Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly 
    2885                 2890                 2895             


Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln Val Leu  Thr Lys Leu 
    2900                 2905                 2910             


Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp 
    2915                 2920                 2925             


Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser 
    2930                 2935                 2940             


Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp 
    2945                 2950                 2955             


Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg 
    2960                 2965                 2970             


Asn Glu  Pro His Gln Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp 
    2975                 2980                 2985             


Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp 
    2990                 2995                 3000             


Ala Thr  Leu Arg Ile Val His  Val Ala Ala Leu Glu  Ala Gly Ala 
    3005                 3010                 3015             


Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met Gln His  Arg Ile Leu 
    3020                 3025                 3030             


Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu 
    3035                 3040                 3045             


Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala 
    3050                 3055                 3060             


Asp Thr  Asp Thr Val Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe 
    3065                 3070                 3075             


Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His Val Trp  Gly Gly Leu 
    3080                 3085                 3090             


Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser 
    3095                 3100                 3105             


Ala Leu  Val Asp Arg Ile Ala  Ala Pro His Gly Ser  Ala Val Arg 
    3110                 3115                 3120             


Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg 
    3125                 3130                 3135             


Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu 
    3140                 3145                 3150             


Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    3155                 3160                 3165             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    3170                 3175                 3180             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    3185                 3190                 3195             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    3200                 3205                 3210             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    3215                 3220                 3225             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    3230                 3235                 3240             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    3245                 3250                 3255             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    3260                 3265                 3270             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    3275                 3280                 3285             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    3290                 3295                 3300             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    3305                 3310                 3315             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    3320                 3325                 3330             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    3335                 3340                 3345             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    3350                 3355                 3360             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    3365                 3370                 3375             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    3380                 3385                 3390             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    3395                 3400                 3405             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    3410                 3415                 3420             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    3425                 3430                 3435             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    3440                 3445                 3450             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    3455                 3460                 3465             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    3470                 3475                 3480             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Thr 
    3485                 3490                 3495             


Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu 
    3500                 3505                 3510             


Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly Pro Pro  Val Glu His 
    3515                 3520                 3525             


Arg Ala  Arg Leu Val Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp 
    3530                 3535                 3540             


Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val 
    3545                 3550                 3555             


His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu 
    3560                 3565                 3570             


Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val 
    3575                 3580                 3585             


Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His 
    3590                 3595                 3600             


Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu 
    3605                 3610                 3615             


Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln 
    3620                 3625                 3630             


Thr Ala  Pro Arg Val His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp 
    3635                 3640                 3645             


Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala 
    3650                 3655                 3660             


Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu 
    3665                 3670                 3675             


Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly 
    3680                 3685                 3690             


Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp 
    3695                 3700                 3705             


Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser 
    3710                 3715                 3720             


Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr 
    3725                 3730                 3735             


Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp 
    3740                 3745                 3750             


Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3755                 3760     


<210>  112
<211>  14592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-MalH

<400>  112
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctac ctggaattgg ggcgctagtt     7680

cccgctcccg tggtaatcgc agcaggccgt acggaggaac caattgccat agtatccatg     7740

gcttgccggt tacccggtgg tgtgaatacc ccacagagac tatgggaatt attacgtgaa     7800

gggggagaaa ccctcagtgg cttccctacc gaccgagggt gggacctcgc gaggttgcat     7860

cacccagacc cagacaaccc cggtacgtca tacgttgata aagggggatt cctggacgat     7920

gcggcagggt ttgacgcaga atttttcggt gtgagcccca gagaagcagc ggctatggac     7980

ccgcagcaga gattactcct cgaaaccagc tgggagttag tcgagaatgc agggattgat     8040

ccacatagcc taagggggac cgccactggt gtcttcctcg gcgttgccaa gtttgggtat     8100

ggcgaggata cggcagctgc cgaagacgtc gaggggtact ctgtcactgg tgtagccccg     8160

gcagtggcgt cgggcagaat tagttacacg atggggttgg aagggccgtc tatttcggtt     8220

gataccgcct gttcctccag tctggttgca ctccaccttg cagtcgagtc gctccggaaa     8280

ggagaaagca gtatggccgt ggtcggggga gcggcggtga tggccacacc gggtgtgttt     8340

gtggattttt cccgacagag agccttggcc gcggatgggc gttcaaaggc gttcggagca     8400

ggtgcagacg ggtttggatt tagcgaaggt gtgacactgg ttctcctaga aagattaagt     8460

gaagcccggc gtaacggcca tgaggtgctg gcagttgtta gaggttccgc attaaaccag     8520

gacggggctt cgaacgggct gagcgccccc tcgggcccgg cacagagaag agtgatacgc     8580

caagcactcg aatcgtgtgg cctagaacca ggtgacgttg acgcggtgga agcgcacggg     8640

acaggaactg cgttagggga cccgatagaa gcaaacgcct tgctggacac ttatggtaga     8700

gatcgtgatg cggatcgacc cctctggtta ggaagtgtta agtcaaatat aggacacact     8760

caggcagcgg cgggagtaac tgggctgctc aaagtagtcc tagccttacg caatggggaa     8820

ctacccgcca ccctacatgt cgaggaaccg acaccgcatg tggattggtc gagcggggga     8880

gttgctctct tggcgggtaa tcagccgtgg cgaagaggtg aacgaacccg tagagccgcc     8940

gtgtccgcat tcgggatcag tggtacgaac gcgcacgtga ttgtggaaga agctccacaa     9000

gaggtgagac cagcgcccgg tcaaggactc tcgcccgcgg tgtcaacctt ggtagtggcg     9060

ggtaaaacta tgcagcgtgt ttcggcaacc gccggtatgc tcgcagattg gatggaaggc     9120

ccaggtgcag atgtggcgct ggcggacgtg gcgcacacgt taaatcatca ccgttcacgg     9180

caaccaaagt tcggtacggt ggtggccagg gaccggacac aggcaatcgc cggactaaga     9240

gcgctggcgg cgggtcagca cgccccaggg gttgttaacc ctgctgaagg aagtccaggt     9300

ccagggacgg tgttcgtgtt tcctggccag gggtcccagc gtgcaggcat gggggaggag     9360

ttggctgcgg ctttccccgt gtttgccaga atccaccagc aagtgtggga tttactcgat     9420

gttcctgatc tcgacgttaa cgaaacgggg tacgcacaac cagcactctt cgcactccaa     9480

gtggcgctgt ttgggctcct cgaatcatgg ggagtacggc cggatgccgt ggtcgggcat     9540

agtgtagggg aattagcggc agggtacgtt tccgggcttt ggagtcttga ggatgcttgc     9600

acgctcgtgt cggcgagagc ccgtctaatg caagccttac cggcaggtgg tgttatggcg     9660

gcagttccag tgtccgaaga cgaagcacgg gctgtgttgg gggaaggagt cgaaatagct     9720

gcggtcaacg gtccgtcgag cgtggttcta agcggtgatg aagcagcagt gctccaggcc     9780

gcggaagggt taggcaagtg gacgcgatta ccgacctcgc atgcattcca ttctgctcgt     9840

atggaaccaa tgctggaaga gtttagagca gtggcggaag gtctaacata caggactccc     9900

caggtggcaa tggccgccgg agaccaggtt atgaccgctg aatactgggt gcgtcaggtt     9960

agggatacag ttcgttttgg cgagcaagtt gcctcgttcg aggatgctgt attcgtggaa    10020

ttgggagcag atcgctctct tgcacggcta gtcgatggta tcgcgatgtt gcacggggat    10080

catgaggcac aggctggtat gcggagagaa caacccttgc ccttaggttt acgaagattg    10140

ctaaccgacc tgcataacgc tggtgctgcc gtcgatttta gtgttttgtg cccacaaggt    10200

cgtctggttg acgcaccgtt accagcctgg tcacaccggt ttctcttcta tgaccgggaa    10260

ggagtggaca atagatcacc agggggaagc acagtggcgg tccacccgct tttactagcc    10320

gcggtggatg tgccgggcca cggtggagcg gttttcacgg gtagactctc gactgacgag    10380

caaccgtggt tagcggagca cgttgtcggg ggaagaaccc tagttcctgg ttctgtttta    10440

gtcgatctag ccttagcggc aggcgaagac gtagggctac cggtgttaga agaattagta    10500

ttgcagaggc cgctggtgct tgccggcgcg ggagcactcc tacggatgtc ggtcggggca    10560

ccagacgaga gcggtagaag aactatcgat gttcacgcag ctgaagacgt cgccgattta    10620

gcagatgccc aatggtccca gcacgccacc gggactttag cccaaggggt agcggcgggg    10680

cccagggaca cagagcaatg gcccccagag gatgccgtcc ggattccatt agacgaccat    10740

tatgatggtc tcgcggaaca gggttatgag tacggtccgt cgtttcaggc gctagtggcc    10800

tacgtggcgg aggatgcgac tgcgacaatg ttagcggaag tcgcgcttcc gggcagcatt    10860

agatcgcaac aaggtctata cgccatccat cccgcactgc tggacgcttg ttttcaatct    10920

gtcggagccc acccagacag tcaatccgtc gggtcaggtc tactcgtacc cctcggtgtt    10980

cggagagttc gtgcgtacgc acccgtaagg accgcccgtt attgttacac ccgcgtcacg    11040

aaagttgaac tagctggggt tgaggccgac atcgacgttc tggatgctca cggcacagtg    11100

cttctagccg tgtgcggtct tcgtatcggg accggagtga gcgagaggga caaacacaac    11160

agagttctca atgagcgcct actcaccatc gaatggcatc agcgtgaact accagaaatg    11220

gacccctcgg gtgccgggaa gtggctccta atctcggact gtgcagcatc cgatgtcacc    11280

gctacacgac tggctgatgc cttccgggag cacagcgctg cgtgcactac catgcggtgg    11340

ccacttcacg atgatcaact agcagccgcc gaccaactcc gggaccaggt gggttcagat    11400

gagttttctg gcgtggtagt actaacaggg ccaaacacag ggacccctca tcagggttcc    11460

gcagaccgtg gcgccgagta cgttaggcgg ttagttggaa tcgctcgtga acttagcgat    11520

cttcccggag cggttccccg tatgtatgtc gtcacaaggg gagcgcagag agtccttgcc    11580

gatgattgtg ttaatttaga acagggaggg ctcagaggtc tgctgaggac catcggtgct    11640

gagcacccac atctccgcgc cacccaaatt gatgttgatg agcagacagg agtagagcag    11700

ctggcgcgac aactcctagc tacatcggag gaagacgaga cagcctggag ggacaacgaa    11760

tggtacgttg cgaggttatg ccccacaccc ctgaggccac aggaacgtag gacaatagtg    11820

gcggaccatc aacagtctgg tatgcggtta caaatacgta cgcccggtgc aatcgatagt    11880

gtggcctttg aacccgcacc cgatgtagag caacccttac gggcgggtga agttcgggtt    11940

gacgttagag caaccggtgt taatttccgt gacgttctac tcgctctcgg gatgtatccc    12000

cagaaagctg acatggggac agaagcagct ggtgttgtaa cagcagtggg acctgatgtc    12060

gatgcgtttg cgcctggtga tagagttcta gggctattcc aaggggcatt tgctccaatt    12120

gcggtgactg accatcgttt actggcacgg gtgccagacg ggtggtcaga tgccgatgcg    12180

gcggcggtgc caatagctta cacgacagca cattatgcgc tgcacgacct ggcggggttg    12240

cgggcggggc aatctgtcct gatacacgcg gcagcgggtg gtgttggtat ggccgctgtt    12300

gcactggcac ggagggccgg cgcagaagtt ctggctaccg caggacctgc aaaacacggt    12360

acgctacggg cattagggct agatgatgaa cacatcgctt cgagtcggga gaccgggttc    12420

gcgcgtaagt tccgagagcg gactggggga cgaggagtgg acgtcgttct aaacagcttg    12480

accggcgaac tattagacga gtccgcggat ctcctcgcgg aggacggagt cttcgtggaa    12540

atgggaaaga ctgatctgcg cgatgcaggg gactttcgtg ggcgctacgc cccgtttgat    12600

ctaggggaag caggcgatga caggctcggg gaaattctac gtgaggtggt gggactgctc    12660

ggtgcagggg aactcgaccg actccctgtt agcgcgtggg aattggggat accccagacg    12720

gggaagtcgt tagtgacgct gccacccgaa caagcgcaag ttttcagacc agacggcact    12780

gtattgatca ccgggggaac gggaacgtta ggtcggctgc tggcccgtca tctggttaca    12840

gagcacgggg tgcgtcacct gctgctagtg tcgaggagag gagcagatgc ccctggatcg    12900

gacgagctga gggccgaaat cgaggatctc ggagcatcag cggaaattgc agcatgtgat    12960

acagccgatc gagacgctct cagcgcgttg ctagatggac tgccgaggcc actgaccgga    13020

gtagttcacg ccgcgggagt cctcgctgac ggtctggtta catccatcga cgagcccgca    13080

gtcgaacaag ttctccgtgc aaaagttgat gcggcctgga acctgcacga gctaactgcg    13140

aacaccggtc tcagcttttt cgtgctgttc tcgtcagccg caagtgtgtt agcggggccg    13200

gggcagggag tatatgcggc agcgaacgaa tctttaaacg ctctggccgc tctgcgtagg    13260

actaggggtt tacccgcaaa agcattggga tggggattat gggcgatagg gcgtgcaata    13320

gcatttgccg agcagaccgg tgacgcaatc gccccggagg aaggcgcgta cgccttcgag    13380

acactactca gacataacag ggcgtactcg ggttacgctc ccgtgatagg gtcaccatgg    13440

ctgactgcgt tcgcccaaca ttcgcccttt gcggagaagt tccagtccct ggggcaaaat    13500

agatccggga cgtctaagtt tctggcagaa ttagtcgatc tgccaagaga agaatggcca    13560

gatcggttac gtcgtctatt agaactggtg aggtctcatg ctgccgcagt ttcggggtat    13620

ggatcggcag accaattacc agaaagaaaa gcattcaaag acctcggatt cgattcactg    13680

gcagcagtcg aactaagaaa tcgtctaggg accgcgacag gcgtccggct gcccagtact    13740

ctggtgttcg accacccaac cccacttgcg gttgcggaac atctacgtga tcgtctaaca    13800

tccggggaag ataaccctat ccccctatgt caaggcgatg gggaggagat gagcacatgg    13860

ctacgtcgtt ttggaccccc agtcgaacat cgggccaggc tagtgtgttt cccccacgca    13920

ggcgcagcgg cggattcata cttagaccta gcaagagcgt tagcaccaga gatcgatgtt    13980

catgctgttc aataccccgg caggcaagac agaagggacg aggagccatt aggaaccgca    14040

ggtgaaattg cagatgaagt ggcagcggtg ctacgtgcgt cgggagggga tgggcctttt    14100

gcacttttcg gccacagtat gggcgccctc atcgcgtacg agacagcaag gcgattagag    14160

agggaaccgg gagggggacc cttacgttta ttcgtgagcg gacaaacagc gccacgtgtc    14220

catgaacgaa gaactgatct gcccggtgac gatggactcg tggacgagct taggcgactt    14280

ggcacctccg aggcagcgct cgcagacgaa gccctgctgg ctatgtctct cccggtgctc    14340

agggcggatt atagggtgtt aagatcctac gcttgggcgg atggtccccc actacgcgcc    14400

ggtataactg ccctctgcgg tgatgcagac ccactaactg caacagggga tgcggaacgc    14460

tggttacaac attccgtgat tccgggtcgg acacggacat ttcccggtgg gcatttttat    14520

ttaggggaac aagtgaccga ggtggcaggg gctgtccgta gagatttact gagagcaggg    14580

ttagcgggtt ga                                                        14592


<210>  113
<211>  4863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-MalH

<400>  113

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro Val Val  Ile Ala Ala 
    2555                 2560                 2565             


Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val Ser Met  Ala Cys Arg 
    2570                 2575                 2580             


Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg Leu Trp  Glu Leu Leu 
    2585                 2590                 2595             


Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe Pro Thr  Asp Arg Gly 
    2600                 2605                 2610             


Trp Asp  Leu Ala Arg Leu His  His Pro Asp Pro Asp  Asn Pro Gly 
    2615                 2620                 2625             


Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu Asp Asp  Ala Ala Gly 
    2630                 2635                 2640             


Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro Arg Glu  Ala Ala Ala 
    2645                 2650                 2655             


Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu Thr Ser  Trp Glu Leu 
    2660                 2665                 2670             


Val Glu  Asn Ala Gly Ile Asp  Pro His Ser Leu Arg  Gly Thr Ala 
    2675                 2680                 2685             


Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe Gly Tyr  Gly Glu Asp 
    2690                 2695                 2700             


Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr Ser Val  Thr Gly Val 
    2705                 2710                 2715             


Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser Tyr Thr  Met Gly Leu 
    2720                 2725                 2730             


Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala Cys Ser  Ser Ser Leu 
    2735                 2740                 2745             


Val Ala  Leu His Leu Ala Val  Glu Ser Leu Arg Lys  Gly Glu Ser 
    2750                 2755                 2760             


Ser Met  Ala Val Val Gly Gly  Ala Ala Val Met Ala  Thr Pro Gly 
    2765                 2770                 2775             


Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala Leu Ala  Ala Asp Gly 
    2780                 2785                 2790             


Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp Gly Phe  Gly Phe Ser 
    2795                 2800                 2805             


Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg Leu Ser  Glu Ala Arg 
    2810                 2815                 2820             


Arg Asn  Gly His Glu Val Leu  Ala Val Val Arg Gly  Ser Ala Leu 
    2825                 2830                 2835             


Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser Ala Pro  Ser Gly Pro 
    2840                 2845                 2850             


Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu Glu Ser  Cys Gly Leu 
    2855                 2860                 2865             


Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala His Gly  Thr Gly Thr 
    2870                 2875                 2880             


Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala Leu Leu  Asp Thr Tyr 
    2885                 2890                 2895             


Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu Trp Leu  Gly Ser Val 
    2900                 2905                 2910             


Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala Ala Gly  Val Thr Gly 
    2915                 2920                 2925             


Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn Gly Glu  Leu Pro Ala 
    2930                 2935                 2940             


Thr Leu  His Val Glu Glu Pro  Thr Pro His Val Asp  Trp Ser Ser 
    2945                 2950                 2955             


Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln Pro Trp  Arg Arg Gly 
    2960                 2965                 2970             


Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala Phe Gly  Ile Ser Gly 
    2975                 2980                 2985             


Thr Asn  Ala His Val Ile Val  Glu Glu Ala Pro Gln  Glu Val Arg 
    2990                 2995                 3000             


Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala Val Ser  Thr Leu Val 
    3005                 3010                 3015             


Val Ala  Gly Lys Thr Met Gln  Arg Val Ser Ala Thr  Ala Gly Met 
    3020                 3025                 3030             


Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala Asp Val  Ala Leu Ala 
    3035                 3040                 3045             


Asp Val  Ala His Thr Leu Asn  His His Arg Ser Arg  Gln Pro Lys 
    3050                 3055                 3060             


Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr Gln Ala  Ile Ala Gly 
    3065                 3070                 3075             


Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala Pro Gly  Val Val Asn 
    3080                 3085                 3090             


Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr Val Phe  Val Phe Pro 
    3095                 3100                 3105             


Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly Glu Glu  Leu Ala Ala 
    3110                 3115                 3120             


Ala Phe  Pro Val Phe Ala Arg  Ile His Gln Gln Val  Trp Asp Leu 
    3125                 3130                 3135             


Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu Thr Gly  Tyr Ala Gln 
    3140                 3145                 3150             


Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu Phe Gly  Leu Leu Glu 
    3155                 3160                 3165             


Ser Trp  Gly Val Arg Pro Asp  Ala Val Val Gly His  Ser Val Gly 
    3170                 3175                 3180             


Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu Trp Ser  Leu Glu Asp 
    3185                 3190                 3195             


Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg Leu Met  Gln Ala Leu 
    3200                 3205                 3210             


Pro Ala  Gly Gly Val Met Ala  Ala Val Pro Val Ser  Glu Asp Glu 
    3215                 3220                 3225             


Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu Ile Ala  Ala Val Asn 
    3230                 3235                 3240             


Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp Glu Ala  Ala Val Leu 
    3245                 3250                 3255             


Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr Arg Leu  Pro Thr Ser 
    3260                 3265                 3270             


His Ala  Phe His Ser Ala Arg  Met Glu Pro Met Leu  Glu Glu Phe 
    3275                 3280                 3285             


Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg Thr Pro  Gln Val Ala 
    3290                 3295                 3300             


Met Ala  Ala Gly Asp Gln Val  Met Thr Ala Glu Tyr  Trp Val Arg 
    3305                 3310                 3315             


Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu Gln Val  Ala Ser Phe 
    3320                 3325                 3330             


Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala Asp Arg  Ser Leu Ala 
    3335                 3340                 3345             


Arg Leu  Val Asp Gly Ile Ala  Met Leu His Gly Asp  His Glu Ala 
    3350                 3355                 3360             


Gln Ala  Gly Met Arg Arg Glu  Gln Pro Leu Pro Leu  Gly Leu Arg 
    3365                 3370                 3375             


Arg Leu  Leu Thr Asp Leu His  Asn Ala Gly Ala Ala  Val Asp Phe 
    3380                 3385                 3390             


Ser Val  Leu Cys Pro Gln Gly  Arg Leu Val Asp Ala  Pro Leu Pro 
    3395                 3400                 3405             


Ala Trp  Ser His Arg Phe Leu  Phe Tyr Asp Arg Glu  Gly Val Asp 
    3410                 3415                 3420             


Asn Arg  Ser Pro Gly Gly Ser  Thr Val Ala Val His  Pro Leu Leu 
    3425                 3430                 3435             


Leu Ala  Ala Val Asp Val Pro  Gly His Gly Gly Ala  Val Phe Thr 
    3440                 3445                 3450             


Gly Arg  Leu Ser Thr Asp Glu  Gln Pro Trp Leu Ala  Glu His Val 
    3455                 3460                 3465             


Val Gly  Gly Arg Thr Leu Val  Pro Gly Ser Val Leu  Val Asp Leu 
    3470                 3475                 3480             


Ala Leu  Ala Ala Gly Glu Asp  Val Gly Leu Pro Val  Leu Glu Glu 
    3485                 3490                 3495             


Leu Val  Leu Gln Arg Pro Leu  Val Leu Ala Gly Ala  Gly Ala Leu 
    3500                 3505                 3510             


Leu Arg  Met Ser Val Gly Ala  Pro Asp Glu Ser Gly  Arg Arg Thr 
    3515                 3520                 3525             


Ile Asp  Val His Ala Ala Glu  Asp Val Ala Asp Leu  Ala Asp Ala 
    3530                 3535                 3540             


Gln Trp  Ser Gln His Ala Thr  Gly Thr Leu Ala Gln  Gly Val Ala 
    3545                 3550                 3555             


Ala Gly  Pro Arg Asp Thr Glu  Gln Trp Pro Pro Glu  Asp Ala Val 
    3560                 3565                 3570             


Arg Ile  Pro Leu Asp Asp His  Tyr Asp Gly Leu Ala  Glu Gln Gly 
    3575                 3580                 3585             


Tyr Glu  Tyr Gly Pro Ser Phe  Gln Ala Leu Val Ala  Tyr Val Ala 
    3590                 3595                 3600             


Glu Asp  Ala Thr Ala Thr Met  Leu Ala Glu Val Ala  Leu Pro Gly 
    3605                 3610                 3615             


Ser Ile  Arg Ser Gln Gln Gly  Leu Tyr Ala Ile His  Pro Ala Leu 
    3620                 3625                 3630             


Leu Asp  Ala Cys Phe Gln Ser  Val Gly Ala His Pro  Asp Ser Gln 
    3635                 3640                 3645             


Ser Val  Gly Ser Gly Leu Leu  Val Pro Leu Gly Val  Arg Arg Val 
    3650                 3655                 3660             


Arg Ala  Tyr Ala Pro Val Arg  Thr Ala Arg Tyr Cys  Tyr Thr Arg 
    3665                 3670                 3675             


Val Thr  Lys Val Glu Leu Ala  Gly Val Glu Ala Asp  Ile Asp Val 
    3680                 3685                 3690             


Leu Asp  Ala His Gly Thr Val  Leu Leu Ala Val Cys  Gly Leu Arg 
    3695                 3700                 3705             


Ile Gly  Thr Gly Val Ser Glu  Arg Asp Lys His Asn  Arg Val Leu 
    3710                 3715                 3720             


Asn Glu  Arg Leu Leu Thr Ile  Glu Trp His Gln Arg  Glu Leu Pro 
    3725                 3730                 3735             


Glu Met  Asp Pro Ser Gly Ala  Gly Lys Trp Leu Leu  Ile Ser Asp 
    3740                 3745                 3750             


Cys Ala  Ala Ser Asp Val Thr  Ala Thr Arg Leu Ala  Asp Ala Phe 
    3755                 3760                 3765             


Arg Glu  His Ser Ala Ala Cys  Thr Thr Met Arg Trp  Pro Leu His 
    3770                 3775                 3780             


Asp Asp  Gln Leu Ala Ala Ala  Asp Gln Leu Arg Asp  Gln Val Gly 
    3785                 3790                 3795             


Ser Asp  Glu Phe Ser Gly Val  Val Val Leu Thr Gly  Pro Asn Thr 
    3800                 3805                 3810             


Gly Thr  Pro His Gln Gly Ser  Ala Asp Arg Gly Ala  Glu Tyr Val 
    3815                 3820                 3825             


Arg Arg  Leu Val Gly Ile Ala  Arg Glu Leu Ser Asp  Leu Pro Gly 
    3830                 3835                 3840             


Ala Val  Pro Arg Met Tyr Val  Val Thr Arg Gly Ala  Gln Arg Val 
    3845                 3850                 3855             


Leu Ala  Asp Asp Cys Val Asn  Leu Glu Gln Gly Gly  Leu Arg Gly 
    3860                 3865                 3870             


Leu Leu  Arg Thr Ile Gly Ala  Glu His Pro His Leu  Arg Ala Thr 
    3875                 3880                 3885             


Gln Ile  Asp Val Asp Glu Gln  Thr Gly Val Glu Gln  Leu Ala Arg 
    3890                 3895                 3900             


Gln Leu  Leu Ala Thr Ser Glu  Glu Asp Glu Thr Ala  Trp Arg Asp 
    3905                 3910                 3915             


Asn Glu  Trp Tyr Val Ala Arg  Leu Cys Pro Thr Pro  Leu Arg Pro 
    3920                 3925                 3930             


Gln Glu  Arg Arg Thr Ile Val  Ala Asp His Gln Gln  Ser Gly Met 
    3935                 3940                 3945             


Arg Leu  Gln Ile Arg Thr Pro  Gly Ala Ile Asp Ser  Val Ala Phe 
    3950                 3955                 3960             


Glu Pro  Ala Pro Asp Val Glu  Gln Pro Leu Arg Ala  Gly Glu Val 
    3965                 3970                 3975             


Arg Val  Asp Val Arg Ala Thr  Gly Val Asn Phe Arg  Asp Val Leu 
    3980                 3985                 3990             


Leu Ala  Leu Gly Met Tyr Pro  Gln Lys Ala Asp Met  Gly Thr Glu 
    3995                 4000                 4005             


Ala Ala  Gly Val Val Thr Ala  Val Gly Pro Asp Val  Asp Ala Phe 
    4010                 4015                 4020             


Ala Pro  Gly Asp Arg Val Leu  Gly Leu Phe Gln Gly  Ala Phe Ala 
    4025                 4030                 4035             


Pro Ile  Ala Val Thr Asp His  Arg Leu Leu Ala Arg  Val Pro Asp 
    4040                 4045                 4050             


Gly Trp  Ser Asp Ala Asp Ala  Ala Ala Val Pro Ile  Ala Tyr Thr 
    4055                 4060                 4065             


Thr Ala  His Tyr Ala Leu His  Asp Leu Ala Gly Leu  Arg Ala Gly 
    4070                 4075                 4080             


Gln Ser  Val Leu Ile His Ala  Ala Ala Gly Gly Val  Gly Met Ala 
    4085                 4090                 4095             


Ala Val  Ala Leu Ala Arg Arg  Ala Gly Ala Glu Val  Leu Ala Thr 
    4100                 4105                 4110             


Ala Gly  Pro Ala Lys His Gly  Thr Leu Arg Ala Leu  Gly Leu Asp 
    4115                 4120                 4125             


Asp Glu  His Ile Ala Ser Ser  Arg Glu Thr Gly Phe  Ala Arg Lys 
    4130                 4135                 4140             


Phe Arg  Glu Arg Thr Gly Gly  Arg Gly Val Asp Val  Val Leu Asn 
    4145                 4150                 4155             


Ser Leu  Thr Gly Glu Leu Leu  Asp Glu Ser Ala Asp  Leu Leu Ala 
    4160                 4165                 4170             


Glu Asp  Gly Val Phe Val Glu  Met Gly Lys Thr Asp  Leu Arg Asp 
    4175                 4180                 4185             


Ala Gly  Asp Phe Arg Gly Arg  Tyr Ala Pro Phe Asp  Leu Gly Glu 
    4190                 4195                 4200             


Ala Gly  Asp Asp Arg Leu Gly  Glu Ile Leu Arg Glu  Val Val Gly 
    4205                 4210                 4215             


Leu Leu  Gly Ala Gly Glu Leu  Asp Arg Leu Pro Val  Ser Ala Trp 
    4220                 4225                 4230             


Glu Leu  Gly Ile Pro Gln Thr  Gly Lys Ser Leu Val  Thr Leu Pro 
    4235                 4240                 4245             


Pro Glu  Gln Ala Gln Val Phe  Arg Pro Asp Gly Thr  Val Leu Ile 
    4250                 4255                 4260             


Thr Gly  Gly Thr Gly Thr Leu  Gly Arg Leu Leu Ala  Arg His Leu 
    4265                 4270                 4275             


Val Thr  Glu His Gly Val Arg  His Leu Leu Leu Val  Ser Arg Arg 
    4280                 4285                 4290             


Gly Ala  Asp Ala Pro Gly Ser  Asp Glu Leu Arg Ala  Glu Ile Glu 
    4295                 4300                 4305             


Asp Leu  Gly Ala Ser Ala Glu  Ile Ala Ala Cys Asp  Thr Ala Asp 
    4310                 4315                 4320             


Arg Asp  Ala Leu Ser Ala Leu  Leu Asp Gly Leu Pro  Arg Pro Leu 
    4325                 4330                 4335             


Thr Gly  Val Val His Ala Ala  Gly Val Leu Ala Asp  Gly Leu Val 
    4340                 4345                 4350             


Thr Ser  Ile Asp Glu Pro Ala  Val Glu Gln Val Leu  Arg Ala Lys 
    4355                 4360                 4365             


Val Asp  Ala Ala Trp Asn Leu  His Glu Leu Thr Ala  Asn Thr Gly 
    4370                 4375                 4380             


Leu Ser  Phe Phe Val Leu Phe  Ser Ser Ala Ala Ser  Val Leu Ala 
    4385                 4390                 4395             


Gly Pro  Gly Gln Gly Val Tyr  Ala Ala Ala Asn Glu  Ser Leu Asn 
    4400                 4405                 4410             


Ala Leu  Ala Ala Leu Arg Arg  Thr Arg Gly Leu Pro  Ala Lys Ala 
    4415                 4420                 4425             


Leu Gly  Trp Gly Leu Trp Ala  Ile Gly Arg Ala Ile  Ala Phe Ala 
    4430                 4435                 4440             


Glu Gln  Thr Gly Asp Ala Ile  Ala Pro Glu Glu Gly  Ala Tyr Ala 
    4445                 4450                 4455             


Phe Glu  Thr Leu Leu Arg His  Asn Arg Ala Tyr Ser  Gly Tyr Ala 
    4460                 4465                 4470             


Pro Val  Ile Gly Ser Pro Trp  Leu Thr Ala Phe Ala  Gln His Ser 
    4475                 4480                 4485             


Pro Phe  Ala Glu Lys Phe Gln  Ser Leu Gly Gln Asn  Arg Ser Gly 
    4490                 4495                 4500             


Thr Ser  Lys Phe Leu Ala Glu  Leu Val Asp Leu Pro  Arg Glu Glu 
    4505                 4510                 4515             


Trp Pro  Asp Arg Leu Arg Arg  Leu Leu Glu Leu Val  Arg Ser His 
    4520                 4525                 4530             


Ala Ala  Ala Val Ser Gly Tyr  Gly Ser Ala Asp Gln  Leu Pro Glu 
    4535                 4540                 4545             


Arg Lys  Ala Phe Lys Asp Leu  Gly Phe Asp Ser Leu  Ala Ala Val 
    4550                 4555                 4560             


Glu Leu  Arg Asn Arg Leu Gly  Thr Ala Thr Gly Val  Arg Leu Pro 
    4565                 4570                 4575             


Ser Thr  Leu Val Phe Asp His  Pro Thr Pro Leu Ala  Val Ala Glu 
    4580                 4585                 4590             


His Leu  Arg Asp Arg Leu Thr  Ser Gly Glu Asp Asn  Pro Ile Pro 
    4595                 4600                 4605             


Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg 
    4610                 4615                 4620             


Phe Gly  Pro Pro Val Glu His  Arg Ala Arg Leu Val  Cys Phe Pro 
    4625                 4630                 4635             


His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala 
    4640                 4645                 4650             


Leu Ala  Pro Glu Ile Asp Val  His Ala Val Gln Tyr  Pro Gly Arg 
    4655                 4660                 4665             


Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile 
    4670                 4675                 4680             


Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly 
    4685                 4690                 4695             


Pro Phe  Ala Leu Phe Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr 
    4700                 4705                 4710             


Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu 
    4715                 4720                 4725             


Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro Arg Val  His Glu Arg 
    4730                 4735                 4740             


Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg 
    4745                 4750                 4755             


Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu 
    4760                 4765                 4770             


Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg 
    4775                 4780                 4785             


Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr 
    4790                 4795                 4800             


Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala 
    4805                 4810                 4815             


Glu Arg  Trp Leu Gln His Ser  Val Ile Pro Gly Arg  Thr Arg Thr 
    4820                 4825                 4830             


Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val 
    4835                 4840                 4845             


Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    4850                 4855                 4860             


<210>  114
<211>  10029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-MalH

<400>  114
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctattgg cttccgctcg tgctccgcgt gacgtccgcc aaacagctca cgctgacgct     6060

gctgaaccgg ctggcgacga cggccttcag cacttgccct tagtagctgc gcaacctgga     6120

atatggatgg ccgagaagtt atctgaacta ccatcagcgt ggagcgtagc gcattacgtg     6180

gagctcactg gtgaggttga ctcgcctctt ttggccaggg cggtagtggc tggccttgca     6240

caagctgaca ccttaagaat gcgtttcaca gaggataatg gggaagtttg gcaatgggta     6300

gacgatgcgt taacatttga gttaccggaa atcatagacc tgcgcactaa catagaccct     6360

cacgggacag ctcaggcctt gatgcaagcg gacctgcaac aggacctacg tgtggattcg     6420

gggaagcctc tggtcttcca tcagctaatt caagtagcgg acaatcgctg gtactggtat     6480

caaaggtacc accacttgct tgtggacggg ttcagttttc cagcgataac caggcaaata     6540

gccaacattt attgcacttg gttgcgagga gagcctacgc ccgcatcccc cttcacgcca     6600

ttcgcagacg ttgttgagga ataccaacag tatcgcgaga gcgaagcgtg gcaacgcgat     6660

gcggcattct gggcggagca acgacggcaa ctaccgcctc ccgcatccct atcacctgcc     6720

ccgctccccg gccggtccgc gtcagccgac attctacggc taaagctgga gttcacagat     6780

ggtgaatttc gacagcttgc tacacaactc agcggggtac aaaggacaga cctagcgctc     6840

gctctggctg cattatggct aggacgactt tgcaatcgaa tggactacgc ggcgggtttc     6900

atatttatgc gccggctcgg cagcgcagcg ttgaccgcaa cgggtccagt tttaaatgtt     6960

cttcctttgg gaatccacat aggcaaccca agcttctctg agcttctcac cagggttcgc     7020

gaggtcgcct taggcgcgta tgcacaccaa catattcctt ttgagatgtt agtagaggca     7080

ctgcaaccag agcgaaacct tagccatact cctctcttcc aagtgatgtt tgtccttcag     7140

aatgcgcccg cgtcccaatt agagttaacc gggatcaccg caaacccaat taaggttaaa     7200

tcaactacca cgaagttcga cctaacttta atcatgcaaa acacagctag cggattagta     7260

ggtgtttggg agtacaacac ggatttattc gacgcgtcaa cgattgagcg aatgacaggg     7320

cactttgtaa ccctcctcga gggcgttatc gccaatccac aacagccgat ctctcaactt     7380

cctattttaa ctacagtgga gcaacagcaa cttttagtcg agtggaataa cacgcaaacc     7440

gactaccccg ctgataagtg tatacatcaa ttattcgagg aacaggtcga gcgcacacca     7500

gacgccgttg ctgtcgtctt tgggaatcag caactcacat acgcgcaatt agacatgtat     7560

gcaaatcgat tggctagact aactgcccac ggaattacca aggagtcaat agtcggtgta     7620

ctttctgagc gttcgccaga tatgctgact gcagttctcg ctgtgttaaa ggcaggaggt     7680

gcatacgtcc cacttgaccc cgtatatcct gaggaaagac tctcttacat gttaaaagat     7740

tcgggagccg cgttacttct gacgcaacca gggctgaagg cgccggtctt ctctggcaaa     7800

acgctcgagg tagacatgac atcattagcc aacgaggaga gtgagtatca cagcttgcat     7860

caggctgact ctgattcgct agcctacgta atatatacgt caggatccac aggtcaacca     7920

aagggggttg cggtggagca cttgcaggca gtctctttct taacaggaat gcaaatgcag     7980

tttcctcttg aggaagacga tataatcatg atgaagacga gtttcagctt tgacgcgtct     8040

gtatggcaat tattctggtg gacattatca ggagcatccg cttacttgct accatcgggt     8100

tgggagaagg atccggcttt aatggttaaa gccatacgcg aggaaggtgt cacgacagcg     8160

catttcatcc cagcaatgct taattccttt ctggaccaag cggagataga agcacctcgg     8220

tctttaaaga gggtcttcgc tggaggagag ccacttgcac cacacactgc agctcgattt     8280

gcctcactct tacccgagac ctccttagta catggatatg gtccaactga ggcaaccgtt     8340

gacgccgcgt tctacgcctg cgatccggag ttagacaagg atcggcttcg cctgcctata     8400

ggaaaacctg tcccaggtgc gcggctttat gtactggacc cccacctggc cgttcaacct     8460

gtcggggtag cgggcgagtt gtatatagca ggagcaggag tagcacgagg ttaccttaac     8520

agacctgagc tgactgagga acgattctta gacgatccct tttaccctgg ggagagaatg     8580

tataagaccg gcgacttggc ccattggcta ccagatgggc aagtagagtt cttgggccgc     8640

ctagacgatc aggtcaagat ccgtggatac aggattgagc ctggagagtg tgaagcagct     8700

cttcgttcta tagagggggt tagggacgcc gcggtggctt cgtgtgctat tgcgcgggag     8760

gacatacctg ggaacaaaca ccttgtagcg tacatagttc ctcaagagga gcaaacatgc     8820

actgagcgat cgaggtccac acttacagtt tcgttcgtcc ggagtttcct taaggagaaa     8880

ctccccgaat atatggtacc gagcgcaata gtgattctag acgctctccc cctgactcct     8940

aatggaaagc tagaccggcg ggcgttaccc gcccctgacc tgcactcaca acttgagaca     9000

attattgctg cggctttctc gagcctgctc gggtgcgacg tacaagacgc ggatgctgac     9060

tttttcgcgc taggtggcca ttcgctgctt gccatgaagc tagccgctca gctttcccga     9120

caagtagcgc ggcaggtgac accaggccaa gttatggtag cttcgactgt cgcaaagctc     9180

gcaacgatca tagacgcgga gttagataaa tacgtcgctc caaggaaccc gataacatcc     9240

ggggaagata accctatccc cctatgtcaa ggcgatgggg aggagatgag cacatggcta     9300

cgtcgttttg gacccccagt cgaacatcgg gccaggctag tgtgtttccc ccacgcaggc     9360

gcagcggcgg attcatactt agacctagca agagcgttag caccagagat cgatgttcat     9420

gctgttcaat accccggcag gcaagacaga agggacgagg agccattagg aaccgcaggt     9480

gaaattgcag atgaagtggc agcggtgcta cgtgcgtcgg gaggggatgg gccttttgca     9540

cttttcggcc acagtatggg cgccctcatc gcgtacgaga cagcaaggcg attagagagg     9600

gaaccgggag ggggaccctt acgtttattc gtgagcggac aaacagcgcc acgtgtccat     9660

gaacgaagaa ctgatctgcc cggtgacgat ggactcgtgg acgagcttag gcgacttggc     9720

acctccgagg cagcgctcgc agacgaagcc ctgctggcta tgtctctccc ggtgctcagg     9780

gcggattata gggtgttaag atcctacgct tgggcggatg gtcccccact acgcgccggt     9840

ataactgccc tctgcggtga tgcagaccca ctaactgcaa caggggatgc ggaacgctgg     9900

ttacaacatt ccgtgattcc gggtcggaca cggacatttc ccggtgggca tttttattta     9960

ggggaacaag tgaccgaggt ggcaggggct gtccgtagag atttactgag agcagggtta    10020

gcgggttga                                                            10029


<210>  115
<211>  4312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-MalH

<400>  115

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    2000                 2005                 2010             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    2015                 2020                 2025             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    2030                 2035                 2040             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    2045                 2050                 2055             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    2060                 2065                 2070             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    2075                 2080                 2085             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    2090                 2095                 2100             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    2105                 2110                 2115             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    2120                 2125                 2130             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    2135                 2140                 2145             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    2150                 2155                 2160             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    2165                 2170                 2175             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    2180                 2185                 2190             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    2195                 2200                 2205             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    2210                 2215                 2220             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    2225                 2230                 2235             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    2240                 2245                 2250             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    2255                 2260                 2265             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    2270                 2275                 2280             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    2285                 2290                 2295             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    2300                 2305                 2310             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2315                 2320                 2325             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2330                 2335                 2340             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2345                 2350                 2355             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2360                 2365                 2370             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2375                 2380                 2385             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2390                 2395                 2400             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2405                 2410                 2415             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2420                 2425                 2430             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2435                 2440                 2445             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2450                 2455                 2460             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2465                 2470                 2475             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2480                 2485                 2490             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2495                 2500                 2505             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2510                 2515                 2520             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2525                 2530                 2535             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2540                 2545                 2550             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2555                 2560                 2565             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2570                 2575                 2580             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2585                 2590                 2595             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2600                 2605                 2610             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2615                 2620                 2625             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2630                 2635                 2640             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2645                 2650                 2655             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2660                 2665                 2670             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2675                 2680                 2685             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2690                 2695                 2700             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2705                 2710                 2715             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2720                 2725                 2730             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2735                 2740                 2745             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2750                 2755                 2760             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2765                 2770                 2775             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2780                 2785                 2790             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2795                 2800                 2805             


Asp His  Glu Ala Gln Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro 
    2810                 2815                 2820             


Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala 
    2825                 2830                 2835             


Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp 
    2840                 2845                 2850             


Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg 
    2855                 2860                 2865             


Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val 
    2870                 2875                 2880             


His Pro  Leu Leu Leu Ala Ala  Val Asp Val Pro Gly  His Gly Gly 
    2885                 2890                 2895             


Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu 
    2900                 2905                 2910             


Ala Glu  His Val Val Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val 
    2915                 2920                 2925             


Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro 
    2930                 2935                 2940             


Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly 
    2945                 2950                 2955             


Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser 
    2960                 2965                 2970             


Gly Arg  Arg Thr Ile Asp Val  His Ala Ala Glu Asp  Val Ala Asp 
    2975                 2980                 2985             


Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala 
    2990                 2995                 3000             


Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro 
    3005                 3010                 3015             


Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu 
    3020                 3025                 3030             


Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val 
    3035                 3040                 3045             


Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val 
    3050                 3055                 3060             


Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile 
    3065                 3070                 3075             


His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln Ser Val  Gly Ala His 
    3080                 3085                 3090             


Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly 
    3095                 3100                 3105             


Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr 
    3110                 3115                 3120             


Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala 
    3125                 3130                 3135             


Asp Ile  Asp Val Leu Asp Ala  His Gly Thr Val Leu  Leu Ala Val 
    3140                 3145                 3150             


Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser Glu Arg  Asp Lys His 
    3155                 3160                 3165             


Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln 
    3170                 3175                 3180             


Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu 
    3185                 3190                 3195             


Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu 
    3200                 3205                 3210             


Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala Cys Thr  Thr Met Arg 
    3215                 3220                 3225             


Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg 
    3230                 3235                 3240             


Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly Val Val  Val Leu Thr 
    3245                 3250                 3255             


Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly 
    3260                 3265                 3270             


Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser 
    3275                 3280                 3285             


Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr Val Val  Thr Arg Gly 
    3290                 3295                 3300             


Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly 
    3305                 3310                 3315             


Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly Ala Glu  His Pro His 
    3320                 3325                 3330             


Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu 
    3335                 3340                 3345             


Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr 
    3350                 3355                 3360             


Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr 
    3365                 3370                 3375             


Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile Val Ala  Asp His Gln 
    3380                 3385                 3390             


Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp 
    3395                 3400                 3405             


Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg 
    3410                 3415                 3420             


Ala Gly  Glu Val Arg Val Asp  Val Arg Ala Thr Gly  Val Asn Phe 
    3425                 3430                 3435             


Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp 
    3440                 3445                 3450             


Met Gly  Thr Glu Ala Ala Gly  Val Val Thr Ala Val  Gly Pro Asp 
    3455                 3460                 3465             


Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln 
    3470                 3475                 3480             


Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp His Arg  Leu Leu Ala 
    3485                 3490                 3495             


Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro 
    3500                 3505                 3510             


Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu His Asp  Leu Ala Gly 
    3515                 3520                 3525             


Leu Arg  Ala Gly Gln Ser Val  Leu Ile His Ala Ala  Ala Gly Gly 
    3530                 3535                 3540             


Val Gly  Met Ala Ala Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu 
    3545                 3550                 3555             


Val Leu  Ala Thr Ala Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala 
    3560                 3565                 3570             


Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly 
    3575                 3580                 3585             


Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp 
    3590                 3595                 3600             


Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala 
    3605                 3610                 3615             


Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val Glu Met  Gly Lys Thr 
    3620                 3625                 3630             


Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe 
    3635                 3640                 3645             


Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg 
    3650                 3655                 3660             


Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro 
    3665                 3670                 3675             


Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu 
    3680                 3685                 3690             


Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly 
    3695                 3700                 3705             


Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu 
    3710                 3715                 3720             


Ala Arg  His Leu Val Thr Glu  His Gly Val Arg His  Leu Leu Leu 
    3725                 3730                 3735             


Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg 
    3740                 3745                 3750             


Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys 
    3755                 3760                 3765             


Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu 
    3770                 3775                 3780             


Pro Arg  Pro Leu Thr Gly Val  Val His Ala Ala Gly  Val Leu Ala 
    3785                 3790                 3795             


Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val 
    3800                 3805                 3810             


Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr 
    3815                 3820                 3825             


Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala 
    3830                 3835                 3840             


Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn 
    3845                 3850                 3855             


Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu 
    3860                 3865                 3870             


Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala 
    3875                 3880                 3885             


Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu 
    3890                 3895                 3900             


Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr 
    3905                 3910                 3915             


Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe 
    3920                 3925                 3930             


Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln 
    3935                 3940                 3945             


Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu 
    3950                 3955                 3960             


Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu 
    3965                 3970                 3975             


Val Arg  Ser His Ala Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp 
    3980                 3985                 3990             


Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser 
    3995                 4000                 4005             


Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly 
    4010                 4015                 4020             


Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp His Pro  Thr Pro Leu 
    4025                 4030                 4035             


Ala Val  Ala Glu His Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp 
    4040                 4045                 4050             


Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr 
    4055                 4060                 4065             


Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu His Arg  Ala Arg Leu 
    4070                 4075                 4080             


Val Cys  Phe Pro His Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp 
    4085                 4090                 4095             


Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp Val His  Ala Val Gln 
    4100                 4105                 4110             


Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr 
    4115                 4120                 4125             


Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser 
    4130                 4135                 4140             


Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly His Ser  Met Gly Ala 
    4145                 4150                 4155             


Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly 
    4160                 4165                 4170             


Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg 
    4175                 4180                 4185             


Val His  Glu Arg Arg Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val 
    4190                 4195                 4200             


Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp 
    4205                 4210                 4215             


Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr 
    4220                 4225                 4230             


Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg 
    4235                 4240                 4245             


Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala 
    4250                 4255                 4260             


Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His Ser Val  Ile Pro Gly 
    4265                 4270                 4275             


Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln 
    4280                 4285                 4290             


Val Thr  Glu Val Ala Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala 
    4295                 4300                 4305             


Gly Leu  Ala Gly 
    4310         


<210>  116
<211>  10029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-MalOH

<400>  116
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgcc attcagacag gcgcatcact gtcaattccg     1560

gcaatccaat cgcgcagcaa ccgtgaccag cacttgccct tagtagctgc gcaacctgga     1620

atatggatgg ccgagaagtt atctgaacta ccatcagcgt ggagcgtagc gcattacgtg     1680

gagctcactg gtgaggttga ctcgcctctt ttggccaggg cggtagtggc tggccttgca     1740

caagctgaca ccttaagaat gcgtttcaca gaggataatg gggaagtttg gcaatgggta     1800

gacgatgcgt taacatttga gttaccggaa atcatagacc tgcgcactaa catagaccct     1860

cacgggacag ctcaggcctt gatgcaagcg gacctgcaac aggacctacg tgtggattcg     1920

gggaagcctc tggtcttcca tcagctaatt caagtagcgg acaatcgctg gtactggtat     1980

caaaggtacc accacttgct tgtggacggg ttcagttttc cagcgataac caggcaaata     2040

gccaacattt attgcacttg gttgcgagga gagcctacgc ccgcatcccc cttcacgcca     2100

ttcgcagacg ttgttgagga ataccaacag tatcgcgaga gcgaagcgtg gcaacgcgat     2160

gcggcattct gggcggagca acgacggcaa ctaccgcctc ccgcatccct atcacctgcc     2220

ccgctccccg gccggtccgc gtcagccgac attctacggc taaagctgga gttcacagat     2280

ggtgaatttc gacagcttgc tacacaactc agcggggtac aaaggacaga cctagcgctc     2340

gctctggctg cattatggct aggacgactt tgcaatcgaa tggactacgc ggcgggtttc     2400

atatttatgc gccggctcgg cagcgcagcg ttgaccgcaa cgggtccagt tttaaatgtt     2460

cttcctttgg gaatccacat aggcaaccca agcttctctg agcttctcac cagggttcgc     2520

gaggtcgcct taggcgcgta tgcacaccaa catattcctt ttgagatgtt agtagaggca     2580

ctgcaaccag agcgaaacct tagccatact cctctcttcc aagtgatgtt tgtccttcag     2640

aatgcgcccg cgtcccaatt agagttaacc gggatcaccg caaacccaat taaggttaaa     2700

tcaactacca cgaagttcga cctaacttta atcatgcaaa acacagctag cggattagta     2760

ggtgtttggg agtacaacac ggatttattc gacgcgtcaa cgattgagcg aatgacaggg     2820

cactttgtaa ccctcctcga gggcgttatc gccaatccac aacagccgat ctctcaactt     2880

cctattttaa ctacagtgga gcaacagcaa cttttagtcg agtggaataa cacgcaaacc     2940

gactaccccg ctgataagtg tatacatcaa ttattcgagg aacaggtcga gcgcacacca     3000

gacgccgttg ctgtcgtctt tgggaatcag caactcagct atcgagagat gcgcgaacaa     3060

gtggttgcac tcgccaattt attacgtgag cggggagtca agccaggaga ctccgttgcc     3120

gtggccttac cacgctctgt tttcttaacc cttgcactac acgcgattgt cgaggcaggt     3180

gccgcctggc tacctcttga cacaggatat cctgacgata gattaaaaat gatgctcgag     3240

gatgcacggc cttcccttct gatcacaaca gacgatcaat taccccgctt cagtgacgta     3300

cctaatctga cctcactctg ttacaacgct cccttgacgc ctcaagggag cgccccttta     3360

cagctgtctc aacctcacca tactgcatat atcatcttta caagtggttc tacgggacgc     3420

cccaagggag taatggttgg tcagactgcg attgtaaatc gtctgttgtg gatgcaaaac     3480

cactaccctt tgacggggga ggacgttgta gcccaaaaga ctccttgctc gttcgatgtc     3540

tcagtctggg agttcttttg gccatttata gcaggggcca aattagttat ggcggagccg     3600

gaagcccacc gagacccact tgcgatgcag caattctttg ctgagtatgg tgtcaccact     3660

acacatttcg tcccatcgat gttagcggcc ttcgtggctt ctcttactcc acaaacggct     3720

aggcaatctt gtgccacact aaagcaagtc ttctgctccg gcgaggcatt acctgcagac     3780

ttgtgccggg aatggcagca actcacagga gctccattgc acaatctata cggaccgacc     3840

gaggccgcag tagacgtatc ttggtatcct gcgtttggcg aggagttagc gcaagtaaga     3900

ggttcgtcag taccaatagg ataccccgta tggaacacgg ggcttcggat actggacgcg     3960

atgatgcatc cggtcccacc aggagtcgcg ggcgatttat acctgactgg gatacagctg     4020

gcccaaggtt acctagggag acctgacctt acggcgtcga ggttcatagc ggatccgttt     4080

gctccgggtg agcgcatgta ccgtacgggc gacgtcgcgc gatggctaga taatggcgcc     4140

gtagagtatc ttggtagatc agacgatcag ttaaagatac ggggacaacg aatagagctt     4200

ggggaaatag accgggtaat gcaggctttg ccagatgtcg agcaagcggt ggcttcgtgt     4260

gctattgcgc gggaggacat acctgggaac aaacaccttg tagcgtacat agttcctcaa     4320

gaggagcaaa catgcactga gcgatcgagg tccacactta cagtttcgtt cgtccggagt     4380

ttccttaagg agaaactccc cgaatatatg gtaccgagcg caatagtgat tctagacgct     4440

ctccccctga ctcctaatgg aaagctagac cggcgggcgt tacccgcccc tgacctgcac     4500

tcacaacttg agacaattat tgctgcggct ttctcgagcc tgctcgggtg cgacgtacaa     4560

gacgcggatg ctgacttttt cgcgctaggt ggccattcgc tgcttgccat gaagctagcc     4620

gctcagcttt cccgacaagt agcgcggcag gtgacaccag gccaagttat ggtagcttcg     4680

actgtcgcaa agctcgcaac gatcatagac gcggagttag ataaatacgt cgctccaagg     4740

aacccgatac ctggaattgg ggcgctagtt cccgctcccg tggtaatcgc agcaggccgt     4800

acggaggaac caattgccat cgtttcgatg gcatgtcgtt taccgggagg agtcaatacg     4860

ccccaacggc tctgggaatt actacgggag ggtggtgaaa ccttgtccgg gttcccaacg     4920

gaccgtggct gggacctagc acggcttcac caccctgatc cggacaaccc cggaacgagc     4980

tacgttgata agggtggatt tctcgacgac gcggcgggtt tcgacgcaga gtttttcggg     5040

gtttcaccaa gggaagctgc cgctatggac cctcagcaac gattactttt agagacctcg     5100

tgggagctag ttgaaaatgc gggcatagat ccacatagcc tgcgagggac agcgacaggg     5160

gtgttcctag gagttgcgaa gtttggttat ggtgaggaca cagcagcagc ggaagatgtt     5220

gaaggttatt cagttaccgg tgttgctccc gctgtggcat ctggccgcat atcctacact     5280

atgggtttag aaggtccttc catctcggtc gataccgcat gctcaagctc gctagtcgcg     5340

cttcatctag ccgtagagtc cctccgaaag ggtgagtcat ctatggcggt ggtgggtggt     5400

gcagccgtta tggcgactcc tggggtattt gttgattttt cacgccaacg ggcgcttgcc     5460

gcagacggcc gttccaaagc gttcggggca ggtgcagatg gttttggttt cagcgaggga     5520

gtcacgctgg ttctactaga gcgtttaagt gaggcgcgtc gtaacggtca tgaagttcta     5580

gctgtagtgc gcgggtccgc gttaaaccag gacggagcga gcaacggact ttcagcaccc     5640

tccggccctg cgcaacgtag agtaataagg caagcgctcg aatcgtgtgg gcttgaaccg     5700

ggggatgttg acgcggttga ggcgcatggt actggtacag cactaggtga cccaatagag     5760

gccaatgcgc tgttggacac ttacgggcga gaccgtgatg cggatcgtcc actttggttg     5820

gggtccgtta agagcaatat tgggcacact caagctgcgg ccggggttac aggactgctg     5880

aaggttgtgt tagcactgcg caatggtgag ctacctgcaa cgttacatgt cgaggaacca     5940

actccacacg tcgattggtc ctcaggtggt gtcgcattac tggcgggtaa tcaaccatgg     6000

cgaaggggag aaaggaccag aagggcggca gtgagcgcct ttggtatctc cggtacaaat     6060

gctcacgtga tagtggaaga ggcgcctcag gaagttcgac ccgcccctgg ccaagggctg     6120

tcgccagccg tgtccacgtt agttgttgca ggtaaaacca tgcagcgtgt aagtgcgaca     6180

gctggaatgc ttgcagactg gatggagggt cctggggccg atgttgcatt ggcggatgtg     6240

gcccataccc tgaaccatca ccgatcaaga cagcccaagt tcgggacggt tgtagcgcgt     6300

gacaggactc aggcgatagc tgggctccgt gcattggcgg ctggtcaaca tgctcctggg     6360

gtcgtcaacc cagctgaagg ttccccagga ccaggcaccg tgttcgtttt tcccggtcaa     6420

ggttcgcaga gggcagggat gggggaggaa ctcgcggcag cctttcctgt cttcgctcga     6480

atacatcagc aagtttggga cctcctagat gttcccgacc tcgacgttaa tgaaaccggg     6540

tacgcccaac cagcgctgtt cgcgcttcag gtcgcgctct ttggccttct ggagtcgtgg     6600

ggtgttaggc cagatgcagt ggtagggcac tcagttggtg agctggccgc ggggtacgtg     6660

tccggtcttt ggtcactaga ggacgcctgc acactagtct cagcaagagc gcgcctaatg     6720

caggcactgc ctgctggagg ggtgatggcg gcagtccccg tctccgagga tgaggcgcgg     6780

gccgtcctgg gcgagggagt tgaaattgcg gctgtgaatg gaccctcgtc cgttgtgctc     6840

tcaggggacg aggcggcagt cttacaggcc gccgaaggtc taggtaagtg gacgcgactg     6900

ccgaccagcc atgcttttca ctcagcgaga atggaaccca tgctagaaga gtttcgggcc     6960

gtagcagagg gtctgaccta tcgtacccct caagtagcta tggctgctgg ggatcaggtg     7020

atgacagcag aatattgggt gcggcaggtt cgggacacag ttcgcttcgg ggagcaagta     7080

gcgtcattcg aggatgcggt gtttgttgag ttaggcgctg acagaagtct agcgcgtttg     7140

gtggacggca tcgccatgct gcacggtgac cacgaagcgc aggccgcgga ccataggcaa     7200

atcaccgaag cggttgcgga tgcttacgtc ttaggccacc ttccggattt tgcggcgctg     7260

cggcggcctc acgcacgaaa gttggactta ccaacttatc ccttcgagcg tagacagtac     7320

tggttcagag atgcgcgtga gaggccggaa caacccagag ataccggcgg acctcgcaca     7380

gaagcagtcc gtctgttaga ggatggtagg attgaagaat tagctgcact tttgggaggg     7440

gccagtgatg accaacacac attacaggtg ctgactaagt tggcggcgca acataaccaa     7500

caacgaacaa cccggtcaat cgctgacgac aggtacgaaa taaggtggga ccgatcgact     7560

tccccactat ccggagcaga tgttgaccaa gcggggagct ggatcgtggt gtcagatgac     7620

gcagatgccg ttcccccgct agtggacttg ctggctgcac gtaacgagcc ccatcaggtt     7680

gttggtctac ccgcttcgga cgcagacgag gagaggctcg cagagactct gcgtgcggct     7740

gcgactgaag atgctaccct tcggatagtc cacgttgcgg cgctcgaagc aggcgctacc     7800

cccagcatgc gttcactgct ccgcatgcag caccgaatac taggtggcac gcggcgggtg     7860

ttcagggcag cggtcgcagc ggagttaaga ggtcccattt ggatagtgac gcggggagca     7920

caaagagtgg ctgacaccga tacagttgcc ccgcatcagt catgcctctg gggatttggg     7980

agggcagcat cgctggagct gccgcacgtt tggggtggcc tagcagattt atcagagggc     8040

ggtgacaatg cggccgatga gtggagtgcg ctagtggacc gcattgccgc accccacggt     8100

tcagcagtta gggaggacca actggcgctg agagacaggg ccgtatatac gccaagactg     8160

gccagacgtt ctgcgccccc gagcgggact cccctacatc tacgagggga tggcacagtg     8220

ttaataacag gtgggactgg tacactaggt aggctattag cgcgtcacct agtaacagag     8280

catggggtgc ggcatctctt actagtttca aggagaggcg ccgatgcccc tggctcggat     8340

gaactgcgcg cagaaataga ggacttaggt gccagcgcgg agatcgcagc gtgtgataca     8400

gcggatcgcg atgccctatc tgccctacta gatggtctcc cccggcccct tacgggtgtc     8460

gttcacgccg ctggcgtgtt agccgatgga cttgtcacta gcattgacga gcctgcggtg     8520

gaacaggttc tccgagcaaa ggtggacgcg gcatggaacc tacacgaact cacagctaat     8580

accgggctat cctttttcgt tcttttctca tcagcagcat cggtcctggc aggtccaggg     8640

caaggagttt atgcggctgc aaatgaatcg ctcaacgcac tagctgcgtt aaggcgaact     8700

aggggtctgc cggccaaggc tctgggatgg ggcctgtggg ccatcgggcg ggcaatcgct     8760

tttgcggagc agaccgggga cgccatcgct ccagaggaag gagcatacgc ttttgaaact     8820

ctgttaaggc ataaccgtgc ctactcggga tatgcgcccg tcattggatc tccctggttg     8880

accgcgttcg cacagcattc cccctttgca gaaaaattcc aatcactcgg acagaatcgg     8940

tcagggacat cgaaattctt agcggagcta gttgacctgc ctcgtgagga atggccggat     9000

aggctcagga gactactaga gttagttagg tcccatgccg ccgcggtctc cggttacggt     9060

agtgcagatc aactgccgga aagaaaagcg ttcaaggatt tggggtttga ttcgctggcc     9120

gccgttgaac tgcgtaaccg gctgggaacg gctacagggg tacgactgcc gtcaacccta     9180

gtatttgatc acccaactcc gctggccgtc gctgagcact taagagatag gctaacatcc     9240

ggggaagata accctatccc cctatgtcaa ggcgatgggg aggagatgag cacatggcta     9300

cgtcgttttg gacccccagt cgaacatcgg gccaggctag tgtgtttccc ccacgcaggc     9360

gcagcggcgg attcatactt agacctagca agagcgttag caccagagat cgatgttcat     9420

gctgttcaat accccggcag gcaagacaga agggacgagg agccattagg aaccgcaggt     9480

gaaattgcag atgaagtggc agcggtgcta cgtgcgtcgg gaggggatgg gccttttgca     9540

cttttcggcc acagtatggg cgccctcatc gcgtacgaga cagcaaggcg attagagagg     9600

gaaccgggag ggggaccctt acgtttattc gtgagcggac aaacagcgcc acgtgtccat     9660

gaacgaagaa ctgatctgcc cggtgacgat ggactcgtgg acgagcttag gcgacttggc     9720

acctccgagg cagcgctcgc agacgaagcc ctgctggcta tgtctctccc ggtgctcagg     9780

gcggattata gggtgttaag atcctacgct tgggcggatg gtcccccact acgcgccggt     9840

ataactgccc tctgcggtga tgcagaccca ctaactgcaa caggggatgc ggaacgctgg     9900

ttacaacatt ccgtgattcc gggtcggaca cggacatttc ccggtgggca tttttattta     9960

ggggaacaag tgaccgaggt ggcaggggct gtccgtagag atttactgag agcagggtta    10020

gcgggttga                                                            10029


<210>  117
<211>  3342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-MalOH

<400>  117

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Ala Ile Gln 
            500                 505                 510         


Thr Gly Ala Ser Leu Ser Ile Pro Ala Ile Gln Ser Arg Ser Asn Arg 
        515                 520                 525             


Asp Gln His Leu Pro Leu Val Ala Ala Gln Pro Gly Ile Trp Met Ala 
    530                 535                 540                 


Glu Lys Leu Ser Glu Leu Pro Ser Ala Trp Ser Val Ala His Tyr Val 
545                 550                 555                 560 


Glu Leu Thr Gly Glu Val Asp Ser Pro Leu Leu Ala Arg Ala Val Val 
                565                 570                 575     


Ala Gly Leu Ala Gln Ala Asp Thr Leu Arg Met Arg Phe Thr Glu Asp 
            580                 585                 590         


Asn Gly Glu Val Trp Gln Trp Val Asp Asp Ala Leu Thr Phe Glu Leu 
        595                 600                 605             


Pro Glu Ile Ile Asp Leu Arg Thr Asn Ile Asp Pro His Gly Thr Ala 
    610                 615                 620                 


Gln Ala Leu Met Gln Ala Asp Leu Gln Gln Asp Leu Arg Val Asp Ser 
625                 630                 635                 640 


Gly Lys Pro Leu Val Phe His Gln Leu Ile Gln Val Ala Asp Asn Arg 
                645                 650                 655     


Trp Tyr Trp Tyr Gln Arg Tyr His His Leu Leu Val Asp Gly Phe Ser 
            660                 665                 670         


Phe Pro Ala Ile Thr Arg Gln Ile Ala Asn Ile Tyr Cys Thr Trp Leu 
        675                 680                 685             


Arg Gly Glu Pro Thr Pro Ala Ser Pro Phe Thr Pro Phe Ala Asp Val 
    690                 695                 700                 


Val Glu Glu Tyr Gln Gln Tyr Arg Glu Ser Glu Ala Trp Gln Arg Asp 
705                 710                 715                 720 


Ala Ala Phe Trp Ala Glu Gln Arg Arg Gln Leu Pro Pro Pro Ala Ser 
                725                 730                 735     


Leu Ser Pro Ala Pro Leu Pro Gly Arg Ser Ala Ser Ala Asp Ile Leu 
            740                 745                 750         


Arg Leu Lys Leu Glu Phe Thr Asp Gly Glu Phe Arg Gln Leu Ala Thr 
        755                 760                 765             


Gln Leu Ser Gly Val Gln Arg Thr Asp Leu Ala Leu Ala Leu Ala Ala 
    770                 775                 780                 


Leu Trp Leu Gly Arg Leu Cys Asn Arg Met Asp Tyr Ala Ala Gly Phe 
785                 790                 795                 800 


Ile Phe Met Arg Arg Leu Gly Ser Ala Ala Leu Thr Ala Thr Gly Pro 
                805                 810                 815     


Val Leu Asn Val Leu Pro Leu Gly Ile His Ile Gly Asn Pro Ser Phe 
            820                 825                 830         


Ser Glu Leu Leu Thr Arg Val Arg Glu Val Ala Leu Gly Ala Tyr Ala 
        835                 840                 845             


His Gln His Ile Pro Phe Glu Met Leu Val Glu Ala Leu Gln Pro Glu 
    850                 855                 860                 


Arg Asn Leu Ser His Thr Pro Leu Phe Gln Val Met Phe Val Leu Gln 
865                 870                 875                 880 


Asn Ala Pro Ala Ser Gln Leu Glu Leu Thr Gly Ile Thr Ala Asn Pro 
                885                 890                 895     


Ile Lys Val Lys Ser Thr Thr Thr Lys Phe Asp Leu Thr Leu Ile Met 
            900                 905                 910         


Gln Asn Thr Ala Ser Gly Leu Val Gly Val Trp Glu Tyr Asn Thr Asp 
        915                 920                 925             


Leu Phe Asp Ala Ser Thr Ile Glu Arg Met Thr Gly His Phe Val Thr 
    930                 935                 940                 


Leu Leu Glu Gly Val Ile Ala Asn Pro Gln Gln Pro Ile Ser Gln Leu 
945                 950                 955                 960 


Pro Ile Leu Thr Thr Val Glu Gln Gln Gln Leu Leu Val Glu Trp Asn 
                965                 970                 975     


Asn Thr Gln Thr Asp Tyr Pro Ala Asp Lys Cys Ile His Gln Leu Phe 
            980                 985                 990         


Glu Glu Gln Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
        995                 1000                 1005             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    1010                 1015                 1020             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    1025                 1030                 1035             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    1040                 1045                 1050             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    1055                 1060                 1065             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    1070                 1075                 1080             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    1085                 1090                 1095             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    1100                 1105                 1110             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    1115                 1120                 1125             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    1130                 1135                 1140             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    1145                 1150                 1155             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    1160                 1165                 1170             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    1175                 1180                 1185             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    1190                 1195                 1200             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    1205                 1210                 1215             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    1220                 1225                 1230             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    1235                 1240                 1245             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    1250                 1255                 1260             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    1265                 1270                 1275             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    1280                 1285                 1290             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    1295                 1300                 1305             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    1310                 1315                 1320             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    1325                 1330                 1335             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    1340                 1345                 1350             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    1355                 1360                 1365             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    1370                 1375                 1380             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    1385                 1390                 1395             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    1400                 1405                 1410             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    1415                 1420                 1425             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    1430                 1435                 1440             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    1445                 1450                 1455             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    1460                 1465                 1470             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    1475                 1480                 1485             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    1490                 1495                 1500             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    1505                 1510                 1515             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    1520                 1525                 1530             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    1535                 1540                 1545             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    1550                 1555                 1560             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    1565                 1570                 1575             


Pro Arg  Asn Pro Ile Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro 
    1580                 1585                 1590             


Val Val  Ile Ala Ala Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val 
    1595                 1600                 1605             


Ser Met  Ala Cys Arg Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg 
    1610                 1615                 1620             


Leu Trp  Glu Leu Leu Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe 
    1625                 1630                 1635             


Pro Thr  Asp Arg Gly Trp Asp  Leu Ala Arg Leu His  His Pro Asp 
    1640                 1645                 1650             


Pro Asp  Asn Pro Gly Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu 
    1655                 1660                 1665             


Asp Asp  Ala Ala Gly Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro 
    1670                 1675                 1680             


Arg Glu  Ala Ala Ala Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu 
    1685                 1690                 1695             


Thr Ser  Trp Glu Leu Val Glu  Asn Ala Gly Ile Asp  Pro His Ser 
    1700                 1705                 1710             


Leu Arg  Gly Thr Ala Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe 
    1715                 1720                 1725             


Gly Tyr  Gly Glu Asp Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr 
    1730                 1735                 1740             


Ser Val  Thr Gly Val Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser 
    1745                 1750                 1755             


Tyr Thr  Met Gly Leu Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala 
    1760                 1765                 1770             


Cys Ser  Ser Ser Leu Val Ala  Leu His Leu Ala Val  Glu Ser Leu 
    1775                 1780                 1785             


Arg Lys  Gly Glu Ser Ser Met  Ala Val Val Gly Gly  Ala Ala Val 
    1790                 1795                 1800             


Met Ala  Thr Pro Gly Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala 
    1805                 1810                 1815             


Leu Ala  Ala Asp Gly Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp 
    1820                 1825                 1830             


Gly Phe  Gly Phe Ser Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg 
    1835                 1840                 1845             


Leu Ser  Glu Ala Arg Arg Asn  Gly His Glu Val Leu  Ala Val Val 
    1850                 1855                 1860             


Arg Gly  Ser Ala Leu Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser 
    1865                 1870                 1875             


Ala Pro  Ser Gly Pro Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu 
    1880                 1885                 1890             


Glu Ser  Cys Gly Leu Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala 
    1895                 1900                 1905             


His Gly  Thr Gly Thr Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala 
    1910                 1915                 1920             


Leu Leu  Asp Thr Tyr Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu 
    1925                 1930                 1935             


Trp Leu  Gly Ser Val Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala 
    1940                 1945                 1950             


Ala Gly  Val Thr Gly Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn 
    1955                 1960                 1965             


Gly Glu  Leu Pro Ala Thr Leu  His Val Glu Glu Pro  Thr Pro His 
    1970                 1975                 1980             


Val Asp  Trp Ser Ser Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln 
    1985                 1990                 1995             


Pro Trp  Arg Arg Gly Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala 
    2000                 2005                 2010             


Phe Gly  Ile Ser Gly Thr Asn  Ala His Val Ile Val  Glu Glu Ala 
    2015                 2020                 2025             


Pro Gln  Glu Val Arg Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala 
    2030                 2035                 2040             


Val Ser  Thr Leu Val Val Ala  Gly Lys Thr Met Gln  Arg Val Ser 
    2045                 2050                 2055             


Ala Thr  Ala Gly Met Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala 
    2060                 2065                 2070             


Asp Val  Ala Leu Ala Asp Val  Ala His Thr Leu Asn  His His Arg 
    2075                 2080                 2085             


Ser Arg  Gln Pro Lys Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr 
    2090                 2095                 2100             


Gln Ala  Ile Ala Gly Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala 
    2105                 2110                 2115             


Pro Gly  Val Val Asn Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr 
    2120                 2125                 2130             


Val Phe  Val Phe Pro Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly 
    2135                 2140                 2145             


Glu Glu  Leu Ala Ala Ala Phe  Pro Val Phe Ala Arg  Ile His Gln 
    2150                 2155                 2160             


Gln Val  Trp Asp Leu Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu 
    2165                 2170                 2175             


Thr Gly  Tyr Ala Gln Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu 
    2180                 2185                 2190             


Phe Gly  Leu Leu Glu Ser Trp  Gly Val Arg Pro Asp  Ala Val Val 
    2195                 2200                 2205             


Gly His  Ser Val Gly Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu 
    2210                 2215                 2220             


Trp Ser  Leu Glu Asp Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg 
    2225                 2230                 2235             


Leu Met  Gln Ala Leu Pro Ala  Gly Gly Val Met Ala  Ala Val Pro 
    2240                 2245                 2250             


Val Ser  Glu Asp Glu Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu 
    2255                 2260                 2265             


Ile Ala  Ala Val Asn Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp 
    2270                 2275                 2280             


Glu Ala  Ala Val Leu Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr 
    2285                 2290                 2295             


Arg Leu  Pro Thr Ser His Ala  Phe His Ser Ala Arg  Met Glu Pro 
    2300                 2305                 2310             


Met Leu  Glu Glu Phe Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg 
    2315                 2320                 2325             


Thr Pro  Gln Val Ala Met Ala  Ala Gly Asp Gln Val  Met Thr Ala 
    2330                 2335                 2340             


Glu Tyr  Trp Val Arg Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu 
    2345                 2350                 2355             


Gln Val  Ala Ser Phe Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala 
    2360                 2365                 2370             


Asp Arg  Ser Leu Ala Arg Leu  Val Asp Gly Ile Ala  Met Leu His 
    2375                 2380                 2385             


Gly Asp  His Glu Ala Gln Ala  Ala Asp His Arg Gln  Ile Thr Glu 
    2390                 2395                 2400             


Ala Val  Ala Asp Ala Tyr Val  Leu Gly His Leu Pro  Asp Phe Ala 
    2405                 2410                 2415             


Ala Leu  Arg Arg Pro His Ala  Arg Lys Leu Asp Leu  Pro Thr Tyr 
    2420                 2425                 2430             


Pro Phe  Glu Arg Arg Gln Tyr  Trp Phe Arg Asp Ala  Arg Glu Arg 
    2435                 2440                 2445             


Pro Glu  Gln Pro Arg Asp Thr  Gly Gly Pro Arg Thr  Glu Ala Val 
    2450                 2455                 2460             


Arg Leu  Leu Glu Asp Gly Arg  Ile Glu Glu Leu Ala  Ala Leu Leu 
    2465                 2470                 2475             


Gly Gly  Ala Ser Asp Asp Gln  His Thr Leu Gln Val  Leu Thr Lys 
    2480                 2485                 2490             


Leu Ala  Ala Gln His Asn Gln  Gln Arg Thr Thr Arg  Ser Ile Ala 
    2495                 2500                 2505             


Asp Asp  Arg Tyr Glu Ile Arg  Trp Asp Arg Ser Thr  Ser Pro Leu 
    2510                 2515                 2520             


Ser Gly  Ala Asp Val Asp Gln  Ala Gly Ser Trp Ile  Val Val Ser 
    2525                 2530                 2535             


Asp Asp  Ala Asp Ala Val Pro  Pro Leu Val Asp Leu  Leu Ala Ala 
    2540                 2545                 2550             


Arg Asn  Glu Pro His Gln Val  Val Gly Leu Pro Ala  Ser Asp Ala 
    2555                 2560                 2565             


Asp Glu  Glu Arg Leu Ala Glu  Thr Leu Arg Ala Ala  Ala Thr Glu 
    2570                 2575                 2580             


Asp Ala  Thr Leu Arg Ile Val  His Val Ala Ala Leu  Glu Ala Gly 
    2585                 2590                 2595             


Ala Thr  Pro Ser Met Arg Ser  Leu Leu Arg Met Gln  His Arg Ile 
    2600                 2605                 2610             


Leu Gly  Gly Thr Arg Arg Val  Phe Arg Ala Ala Val  Ala Ala Glu 
    2615                 2620                 2625             


Leu Arg  Gly Pro Ile Trp Ile  Val Thr Arg Gly Ala  Gln Arg Val 
    2630                 2635                 2640             


Ala Asp  Thr Asp Thr Val Ala  Pro His Gln Ser Cys  Leu Trp Gly 
    2645                 2650                 2655             


Phe Gly  Arg Ala Ala Ser Leu  Glu Leu Pro His Val  Trp Gly Gly 
    2660                 2665                 2670             


Leu Ala  Asp Leu Ser Glu Gly  Gly Asp Asn Ala Ala  Asp Glu Trp 
    2675                 2680                 2685             


Ser Ala  Leu Val Asp Arg Ile  Ala Ala Pro His Gly  Ser Ala Val 
    2690                 2695                 2700             


Arg Glu  Asp Gln Leu Ala Leu  Arg Asp Arg Ala Val  Tyr Thr Pro 
    2705                 2710                 2715             


Arg Leu  Ala Arg Arg Ser Ala  Pro Pro Ser Gly Thr  Pro Leu His 
    2720                 2725                 2730             


Leu Arg  Gly Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2735                 2740                 2745             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2750                 2755                 2760             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2765                 2770                 2775             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2780                 2785                 2790             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2795                 2800                 2805             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2810                 2815                 2820             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2825                 2830                 2835             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2840                 2845                 2850             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2855                 2860                 2865             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2870                 2875                 2880             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2885                 2890                 2895             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2900                 2905                 2910             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2915                 2920                 2925             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2930                 2935                 2940             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2945                 2950                 2955             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2960                 2965                 2970             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2975                 2980                 2985             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2990                 2995                 3000             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    3005                 3010                 3015             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    3020                 3025                 3030             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    3035                 3040                 3045             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    3050                 3055                 3060             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    3065                 3070                 3075             


Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly 
    3080                 3085                 3090             


Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu 
    3095                 3100                 3105             


His Arg  Ala Arg Leu Val Cys  Phe Pro His Ala Gly  Ala Ala Ala 
    3110                 3115                 3120             


Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp 
    3125                 3130                 3135             


Val His  Ala Val Gln Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu 
    3140                 3145                 3150             


Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala 
    3155                 3160                 3165             


Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly 
    3170                 3175                 3180             


His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu 
    3185                 3190                 3195             


Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly 
    3200                 3205                 3210             


Gln Thr  Ala Pro Arg Val His  Glu Arg Arg Thr Asp  Leu Pro Gly 
    3215                 3220                 3225             


Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu 
    3230                 3235                 3240             


Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val 
    3245                 3250                 3255             


Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp 
    3260                 3265                 3270             


Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala 
    3275                 3280                 3285             


Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His 
    3290                 3295                 3300             


Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe 
    3305                 3310                 3315             


Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala Gly Ala  Val Arg Arg 
    3320                 3325                 3330             


Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    3335                 3340         


<210>  118
<211>  11682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-MalH

<400>  118
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgcc attcagacag gcgcatcact gtcaattccg     1560

gcaatccaat cgcgcagcaa ccgtgaccag cacttgccct tagtagctgc gcaacctgga     1620

atatggatgg ccgagaagtt atctgaacta ccatcagcgt ggagcgtagc gcattacgtg     1680

gagctcactg gtgaggttga ctcgcctctt ttggccaggg cggtagtggc tggccttgca     1740

caagctgaca ccttaagaat gcgtttcaca gaggataatg gggaagtttg gcaatgggta     1800

gacgatgcgt taacatttga gttaccggaa atcatagacc tgcgcactaa catagaccct     1860

cacgggacag ctcaggcctt gatgcaagcg gacctgcaac aggacctacg tgtggattcg     1920

gggaagcctc tggtcttcca tcagctaatt caagtagcgg acaatcgctg gtactggtat     1980

caaaggtacc accacttgct tgtggacggg ttcagttttc cagcgataac caggcaaata     2040

gccaacattt attgcacttg gttgcgagga gagcctacgc ccgcatcccc cttcacgcca     2100

ttcgcagacg ttgttgagga ataccaacag tatcgcgaga gcgaagcgtg gcaacgcgat     2160

gcggcattct gggcggagca acgacggcaa ctaccgcctc ccgcatccct atcacctgcc     2220

ccgctccccg gccggtccgc gtcagccgac attctacggc taaagctgga gttcacagat     2280

ggtgaatttc gacagcttgc tacacaactc agcggggtac aaaggacaga cctagcgctc     2340

gctctggctg cattatggct aggacgactt tgcaatcgaa tggactacgc ggcgggtttc     2400

atatttatgc gccggctcgg cagcgcagcg ttgaccgcaa cgggtccagt tttaaatgtt     2460

cttcctttgg gaatccacat aggcaaccca agcttctctg agcttctcac cagggttcgc     2520

gaggtcgcct taggcgcgta tgcacaccaa catattcctt ttgagatgtt agtagaggca     2580

ctgcaaccag agcgaaacct tagccatact cctctcttcc aagtgatgtt tgtccttcag     2640

aatgcgcccg cgtcccaatt agagttaacc gggatcaccg caaacccaat taaggttaaa     2700

tcaactacca cgaagttcga cctaacttta atcatgcaaa acacagctag cggattagta     2760

ggtgtttggg agtacaacac ggatttattc gacgcgtcaa cgattgagcg aatgacaggg     2820

cactttgtaa ccctcctcga gggcgttatc gccaatccac aacagccgat ctctcaactt     2880

cctattttaa ctacagtgga gcaacagcaa cttttagtcg agtggaataa cacgcaaacc     2940

gactaccccg ctgataagtg tatacatcaa ttattcgagg aacaggtcga gcgcacacca     3000

gacgccgttg ctgtcgtctt tgggaatcag caactcagct atcgagagat gcgcgaacaa     3060

gtggttgcac tcgccaattt attacgtgag cggggagtca agccaggaga ctccgttgcc     3120

gtggccttac cacgctctgt tttcttaacc cttgcactac acgcgattgt cgaggcaggt     3180

gccgcctggc tacctcttga cacaggatat cctgacgata gattaaaaat gatgctcgag     3240

gatgcacggc cttcccttct gatcacaaca gacgatcaat taccccgctt cagtgacgta     3300

cctaatctga cctcactctg ttacaacgct cccttgacgc ctcaagggag cgccccttta     3360

cagctgtctc aacctcacca tactgcatat atcatcttta caagtggttc tacgggacgc     3420

cccaagggag taatggttgg tcagactgcg attgtaaatc gtctgttgtg gatgcaaaac     3480

cactaccctt tgacggggga ggacgttgta gcccaaaaga ctccttgctc gttcgatgtc     3540

tcagtctggg agttcttttg gccatttata gcaggggcca aattagttat ggcggagccg     3600

gaagcccacc gagacccact tgcgatgcag caattctttg ctgagtatgg tgtcaccact     3660

acacatttcg tcccatcgat gttagcggcc ttcgtggctt ctcttactcc acaaacggct     3720

aggcaatctt gtgccacact aaagcaagtc ttctgctccg gcgaggcatt acctgcagac     3780

ttgtgccggg aatggcagca actcacagga gctccattgc acaatctata cggaccgacc     3840

gaggccgcag tagacgtatc ttggtatcct gcgtttggcg aggagttagc gcaagtaaga     3900

ggttcgtcag taccaatagg ataccccgta tggaacacgg ggcttcggat actggacgcg     3960

atgatgcatc cggtcccacc aggagtcgcg ggcgatttat acctgactgg gatacagctg     4020

gcccaaggtt acctagggag acctgacctt acggcgtcga ggttcatagc ggatccgttt     4080

gctccgggtg agcgcatgta ccgtacgggc gacgtcgcgc gatggctaga taatggcgcc     4140

gtagagtatc ttggtagatc agacgatcag ttaaagatac ggggacaacg aatagagctt     4200

ggggaaatag accgggtaat gcaggctttg ccagatgtcg agcaagcggt ggcttcgtgt     4260

gctattgcgc gggaggacat acctgggaac aaacaccttg tagcgtacat agttcctcaa     4320

gaggagcaaa catgcactga gcgatcgagg tccacactta cagtttcgtt cgtccggagt     4380

ttccttaagg agaaactccc cgaatatatg gtaccgagcg caatagtgat tctagacgct     4440

ctccccctga ctcctaatgg aaagctagac cggcgggcgt tacccgcccc tgacctgcac     4500

tcacaacttg agacaattat tgctgcggct ttctcgagcc tgctcgggtg cgacgtacaa     4560

gacgcggatg ctgacttttt cgcgctaggt ggccattcgc tgcttgccat gaagctagcc     4620

gctcagcttt cccgacaagt agcgcggcag gtgacaccag gccaagttat ggtagcttcg     4680

actgtcgcaa agctcgcaac gatcatagac gcggagttag ataaatacgt cgctccaagg     4740

aacccgatac ctggaattgg ggcgctagtt cccgctcccg tggtaatcgc agcaggccgt     4800

acggaggaac caattgccat agtatccatg gcttgccggt tacccggtgg tgtgaatacc     4860

ccacagagac tatgggaatt attacgtgaa gggggagaaa ccctcagtgg cttccctacc     4920

gaccgagggt gggacctcgc gaggttgcat cacccagacc cagacaaccc cggtacgtca     4980

tacgttgata aagggggatt cctggacgat gcggcagggt ttgacgcaga atttttcggt     5040

gtgagcccca gagaagcagc ggctatggac ccgcagcaga gattactcct cgaaaccagc     5100

tgggagttag tcgagaatgc agggattgat ccacatagcc taagggggac cgccactggt     5160

gtcttcctcg gcgttgccaa gtttgggtat ggcgaggata cggcagctgc cgaagacgtc     5220

gaggggtact ctgtcactgg tgtagccccg gcagtggcgt cgggcagaat tagttacacg     5280

atggggttgg aagggccgtc tatttcggtt gataccgcct gttcctccag tctggttgca     5340

ctccaccttg cagtcgagtc gctccggaaa ggagaaagca gtatggccgt ggtcggggga     5400

gcggcggtga tggccacacc gggtgtgttt gtggattttt cccgacagag agccttggcc     5460

gcggatgggc gttcaaaggc gttcggagca ggtgcagacg ggtttggatt tagcgaaggt     5520

gtgacactgg ttctcctaga aagattaagt gaagcccggc gtaacggcca tgaggtgctg     5580

gcagttgtta gaggttccgc attaaaccag gacggggctt cgaacgggct gagcgccccc     5640

tcgggcccgg cacagagaag agtgatacgc caagcactcg aatcgtgtgg cctagaacca     5700

ggtgacgttg acgcggtgga agcgcacggg acaggaactg cgttagggga cccgatagaa     5760

gcaaacgcct tgctggacac ttatggtaga gatcgtgatg cggatcgacc cctctggtta     5820

ggaagtgtta agtcaaatat aggacacact caggcagcgg cgggagtaac tgggctgctc     5880

aaagtagtcc tagccttacg caatggggaa ctacccgcca ccctacatgt cgaggaaccg     5940

acaccgcatg tggattggtc gagcggggga gttgctctct tggcgggtaa tcagccgtgg     6000

cgaagaggtg aacgaacccg tagagccgcc gtgtccgcat tcgggatcag tggtacgaac     6060

gcgcacgtga ttgtggaaga agctccacaa gaggtgagac cagcgcccgg tcaaggactc     6120

tcgcccgcgg tgtcaacctt ggtagtggcg ggtaaaacta tgcagcgtgt ttcggcaacc     6180

gccggtatgc tcgcagattg gatggaaggc ccaggtgcag atgtggcgct ggcggacgtg     6240

gcgcacacgt taaatcatca ccgttcacgg caaccaaagt tcggtacggt ggtggccagg     6300

gaccggacac aggcaatcgc cggactaaga gcgctggcgg cgggtcagca cgccccaggg     6360

gttgttaacc ctgctgaagg aagtccaggt ccagggacgg tgttcgtgtt tcctggccag     6420

gggtcccagc gtgcaggcat gggggaggag ttggctgcgg ctttccccgt gtttgccaga     6480

atccaccagc aagtgtggga tttactcgat gttcctgatc tcgacgttaa cgaaacgggg     6540

tacgcacaac cagcactctt cgcactccaa gtggcgctgt ttgggctcct cgaatcatgg     6600

ggagtacggc cggatgccgt ggtcgggcat agtgtagggg aattagcggc agggtacgtt     6660

tccgggcttt ggagtcttga ggatgcttgc acgctcgtgt cggcgagagc ccgtctaatg     6720

caagccttac cggcaggtgg tgttatggcg gcagttccag tgtccgaaga cgaagcacgg     6780

gctgtgttgg gggaaggagt cgaaatagct gcggtcaacg gtccgtcgag cgtggttcta     6840

agcggtgatg aagcagcagt gctccaggcc gcggaagggt taggcaagtg gacgcgatta     6900

ccgacctcgc atgcattcca ttctgctcgt atggaaccaa tgctggaaga gtttagagca     6960

gtggcggaag gtctaacata caggactccc caggtggcaa tggccgccgg agaccaggtt     7020

atgaccgctg aatactgggt gcgtcaggtt agggatacag ttcgttttgg cgagcaagtt     7080

gcctcgttcg aggatgctgt attcgtggaa ttgggagcag atcgctctct tgcacggcta     7140

gtcgatggta tcgcgatgtt gcacggggat catgaggcac aggctggtat gcggagagaa     7200

caacccttgc ccttaggttt acgaagattg ctaaccgacc tgcataacgc tggtgctgcc     7260

gtcgatttta gtgttttgtg cccacaaggt cgtctggttg acgcaccgtt accagcctgg     7320

tcacaccggt ttctcttcta tgaccgggaa ggagtggaca atagatcacc agggggaagc     7380

acagtggcgg tccacccgct tttactagcc gcggtggatg tgccgggcca cggtggagcg     7440

gttttcacgg gtagactctc gactgacgag caaccgtggt tagcggagca cgttgtcggg     7500

ggaagaaccc tagttcctgg ttctgtttta gtcgatctag ccttagcggc aggcgaagac     7560

gtagggctac cggtgttaga agaattagta ttgcagaggc cgctggtgct tgccggcgcg     7620

ggagcactcc tacggatgtc ggtcggggca ccagacgaga gcggtagaag aactatcgat     7680

gttcacgcag ctgaagacgt cgccgattta gcagatgccc aatggtccca gcacgccacc     7740

gggactttag cccaaggggt agcggcgggg cccagggaca cagagcaatg gcccccagag     7800

gatgccgtcc ggattccatt agacgaccat tatgatggtc tcgcggaaca gggttatgag     7860

tacggtccgt cgtttcaggc gctagtggcc tacgtggcgg aggatgcgac tgcgacaatg     7920

ttagcggaag tcgcgcttcc gggcagcatt agatcgcaac aaggtctata cgccatccat     7980

cccgcactgc tggacgcttg ttttcaatct gtcggagccc acccagacag tcaatccgtc     8040

gggtcaggtc tactcgtacc cctcggtgtt cggagagttc gtgcgtacgc acccgtaagg     8100

accgcccgtt attgttacac ccgcgtcacg aaagttgaac tagctggggt tgaggccgac     8160

atcgacgttc tggatgctca cggcacagtg cttctagccg tgtgcggtct tcgtatcggg     8220

accggagtga gcgagaggga caaacacaac agagttctca atgagcgcct actcaccatc     8280

gaatggcatc agcgtgaact accagaaatg gacccctcgg gtgccgggaa gtggctccta     8340

atctcggact gtgcagcatc cgatgtcacc gctacacgac tggctgatgc cttccgggag     8400

cacagcgctg cgtgcactac catgcggtgg ccacttcacg atgatcaact agcagccgcc     8460

gaccaactcc gggaccaggt gggttcagat gagttttctg gcgtggtagt actaacaggg     8520

ccaaacacag ggacccctca tcagggttcc gcagaccgtg gcgccgagta cgttaggcgg     8580

ttagttggaa tcgctcgtga acttagcgat cttcccggag cggttccccg tatgtatgtc     8640

gtcacaaggg gagcgcagag agtccttgcc gatgattgtg ttaatttaga acagggaggg     8700

ctcagaggtc tgctgaggac catcggtgct gagcacccac atctccgcgc cacccaaatt     8760

gatgttgatg agcagacagg agtagagcag ctggcgcgac aactcctagc tacatcggag     8820

gaagacgaga cagcctggag ggacaacgaa tggtacgttg cgaggttatg ccccacaccc     8880

ctgaggccac aggaacgtag gacaatagtg gcggaccatc aacagtctgg tatgcggtta     8940

caaatacgta cgcccggtgc aatcgatagt gtggcctttg aacccgcacc cgatgtagag     9000

caacccttac gggcgggtga agttcgggtt gacgttagag caaccggtgt taatttccgt     9060

gacgttctac tcgctctcgg gatgtatccc cagaaagctg acatggggac agaagcagct     9120

ggtgttgtaa cagcagtggg acctgatgtc gatgcgtttg cgcctggtga tagagttcta     9180

gggctattcc aaggggcatt tgctccaatt gcggtgactg accatcgttt actggcacgg     9240

gtgccagacg ggtggtcaga tgccgatgcg gcggcggtgc caatagctta cacgacagca     9300

cattatgcgc tgcacgacct ggcggggttg cgggcggggc aatctgtcct gatacacgcg     9360

gcagcgggtg gtgttggtat ggccgctgtt gcactggcac ggagggccgg cgcagaagtt     9420

ctggctaccg caggacctgc aaaacacggt acgctacggg cattagggct agatgatgaa     9480

cacatcgctt cgagtcggga gaccgggttc gcgcgtaagt tccgagagcg gactggggga     9540

cgaggagtgg acgtcgttct aaacagcttg accggcgaac tattagacga gtccgcggat     9600

ctcctcgcgg aggacggagt cttcgtggaa atgggaaaga ctgatctgcg cgatgcaggg     9660

gactttcgtg ggcgctacgc cccgtttgat ctaggggaag caggcgatga caggctcggg     9720

gaaattctac gtgaggtggt gggactgctc ggtgcagggg aactcgaccg actccctgtt     9780

agcgcgtggg aattggggat accccagacg gggaagtcgt tagtgacgct gccacccgaa     9840

caagcgcaag ttttcagacc agacggcact gtattgatca ccgggggaac gggaacgtta     9900

ggtcggctgc tggcccgtca tctggttaca gagcacgggg tgcgtcacct gctgctagtg     9960

tcgaggagag gagcagatgc ccctggatcg gacgagctga gggccgaaat cgaggatctc    10020

ggagcatcag cggaaattgc agcatgtgat acagccgatc gagacgctct cagcgcgttg    10080

ctagatggac tgccgaggcc actgaccgga gtagttcacg ccgcgggagt cctcgctgac    10140

ggtctggtta catccatcga cgagcccgca gtcgaacaag ttctccgtgc aaaagttgat    10200

gcggcctgga acctgcacga gctaactgcg aacaccggtc tcagcttttt cgtgctgttc    10260

tcgtcagccg caagtgtgtt agcggggccg gggcagggag tatatgcggc agcgaacgaa    10320

tctttaaacg ctctggccgc tctgcgtagg actaggggtt tacccgcaaa agcattggga    10380

tggggattat gggcgatagg gcgtgcaata gcatttgccg agcagaccgg tgacgcaatc    10440

gccccggagg aaggcgcgta cgccttcgag acactactca gacataacag ggcgtactcg    10500

ggttacgctc ccgtgatagg gtcaccatgg ctgactgcgt tcgcccaaca ttcgcccttt    10560

gcggagaagt tccagtccct ggggcaaaat agatccggga cgtctaagtt tctggcagaa    10620

ttagtcgatc tgccaagaga agaatggcca gatcggttac gtcgtctatt agaactggtg    10680

aggtctcatg ctgccgcagt ttcggggtat ggatcggcag accaattacc agaaagaaaa    10740

gcattcaaag acctcggatt cgattcactg gcagcagtcg aactaagaaa tcgtctaggg    10800

accgcgacag gcgtccggct gcccagtact ctggtgttcg accacccaac cccacttgcg    10860

gttgcggaac atctacgtga tcgtctaaca tccggggaag ataaccctat ccccctatgt    10920

caaggcgatg gggaggagat gagcacatgg ctacgtcgtt ttggaccccc agtcgaacat    10980

cgggccaggc tagtgtgttt cccccacgca ggcgcagcgg cggattcata cttagaccta    11040

gcaagagcgt tagcaccaga gatcgatgtt catgctgttc aataccccgg caggcaagac    11100

agaagggacg aggagccatt aggaaccgca ggtgaaattg cagatgaagt ggcagcggtg    11160

ctacgtgcgt cgggagggga tgggcctttt gcacttttcg gccacagtat gggcgccctc    11220

atcgcgtacg agacagcaag gcgattagag agggaaccgg gagggggacc cttacgttta    11280

ttcgtgagcg gacaaacagc gccacgtgtc catgaacgaa gaactgatct gcccggtgac    11340

gatggactcg tggacgagct taggcgactt ggcacctccg aggcagcgct cgcagacgaa    11400

gccctgctgg ctatgtctct cccggtgctc agggcggatt atagggtgtt aagatcctac    11460

gcttgggcgg atggtccccc actacgcgcc ggtataactg ccctctgcgg tgatgcagac    11520

ccactaactg caacagggga tgcggaacgc tggttacaac attccgtgat tccgggtcgg    11580

acacggacat ttcccggtgg gcatttttat ttaggggaac aagtgaccga ggtggcaggg    11640

gctgtccgta gagatttact gagagcaggg ttagcgggtt ga                       11682


<210>  119
<211>  3893
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-MalH

<400>  119

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Ala Ile Gln 
            500                 505                 510         


Thr Gly Ala Ser Leu Ser Ile Pro Ala Ile Gln Ser Arg Ser Asn Arg 
        515                 520                 525             


Asp Gln His Leu Pro Leu Val Ala Ala Gln Pro Gly Ile Trp Met Ala 
    530                 535                 540                 


Glu Lys Leu Ser Glu Leu Pro Ser Ala Trp Ser Val Ala His Tyr Val 
545                 550                 555                 560 


Glu Leu Thr Gly Glu Val Asp Ser Pro Leu Leu Ala Arg Ala Val Val 
                565                 570                 575     


Ala Gly Leu Ala Gln Ala Asp Thr Leu Arg Met Arg Phe Thr Glu Asp 
            580                 585                 590         


Asn Gly Glu Val Trp Gln Trp Val Asp Asp Ala Leu Thr Phe Glu Leu 
        595                 600                 605             


Pro Glu Ile Ile Asp Leu Arg Thr Asn Ile Asp Pro His Gly Thr Ala 
    610                 615                 620                 


Gln Ala Leu Met Gln Ala Asp Leu Gln Gln Asp Leu Arg Val Asp Ser 
625                 630                 635                 640 


Gly Lys Pro Leu Val Phe His Gln Leu Ile Gln Val Ala Asp Asn Arg 
                645                 650                 655     


Trp Tyr Trp Tyr Gln Arg Tyr His His Leu Leu Val Asp Gly Phe Ser 
            660                 665                 670         


Phe Pro Ala Ile Thr Arg Gln Ile Ala Asn Ile Tyr Cys Thr Trp Leu 
        675                 680                 685             


Arg Gly Glu Pro Thr Pro Ala Ser Pro Phe Thr Pro Phe Ala Asp Val 
    690                 695                 700                 


Val Glu Glu Tyr Gln Gln Tyr Arg Glu Ser Glu Ala Trp Gln Arg Asp 
705                 710                 715                 720 


Ala Ala Phe Trp Ala Glu Gln Arg Arg Gln Leu Pro Pro Pro Ala Ser 
                725                 730                 735     


Leu Ser Pro Ala Pro Leu Pro Gly Arg Ser Ala Ser Ala Asp Ile Leu 
            740                 745                 750         


Arg Leu Lys Leu Glu Phe Thr Asp Gly Glu Phe Arg Gln Leu Ala Thr 
        755                 760                 765             


Gln Leu Ser Gly Val Gln Arg Thr Asp Leu Ala Leu Ala Leu Ala Ala 
    770                 775                 780                 


Leu Trp Leu Gly Arg Leu Cys Asn Arg Met Asp Tyr Ala Ala Gly Phe 
785                 790                 795                 800 


Ile Phe Met Arg Arg Leu Gly Ser Ala Ala Leu Thr Ala Thr Gly Pro 
                805                 810                 815     


Val Leu Asn Val Leu Pro Leu Gly Ile His Ile Gly Asn Pro Ser Phe 
            820                 825                 830         


Ser Glu Leu Leu Thr Arg Val Arg Glu Val Ala Leu Gly Ala Tyr Ala 
        835                 840                 845             


His Gln His Ile Pro Phe Glu Met Leu Val Glu Ala Leu Gln Pro Glu 
    850                 855                 860                 


Arg Asn Leu Ser His Thr Pro Leu Phe Gln Val Met Phe Val Leu Gln 
865                 870                 875                 880 


Asn Ala Pro Ala Ser Gln Leu Glu Leu Thr Gly Ile Thr Ala Asn Pro 
                885                 890                 895     


Ile Lys Val Lys Ser Thr Thr Thr Lys Phe Asp Leu Thr Leu Ile Met 
            900                 905                 910         


Gln Asn Thr Ala Ser Gly Leu Val Gly Val Trp Glu Tyr Asn Thr Asp 
        915                 920                 925             


Leu Phe Asp Ala Ser Thr Ile Glu Arg Met Thr Gly His Phe Val Thr 
    930                 935                 940                 


Leu Leu Glu Gly Val Ile Ala Asn Pro Gln Gln Pro Ile Ser Gln Leu 
945                 950                 955                 960 


Pro Ile Leu Thr Thr Val Glu Gln Gln Gln Leu Leu Val Glu Trp Asn 
                965                 970                 975     


Asn Thr Gln Thr Asp Tyr Pro Ala Asp Lys Cys Ile His Gln Leu Phe 
            980                 985                 990         


Glu Glu Gln Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
        995                 1000                 1005             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    1010                 1015                 1020             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    1025                 1030                 1035             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    1040                 1045                 1050             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    1055                 1060                 1065             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    1070                 1075                 1080             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    1085                 1090                 1095             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    1100                 1105                 1110             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    1115                 1120                 1125             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    1130                 1135                 1140             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    1145                 1150                 1155             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    1160                 1165                 1170             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    1175                 1180                 1185             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    1190                 1195                 1200             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    1205                 1210                 1215             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    1220                 1225                 1230             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    1235                 1240                 1245             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    1250                 1255                 1260             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    1265                 1270                 1275             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    1280                 1285                 1290             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    1295                 1300                 1305             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    1310                 1315                 1320             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    1325                 1330                 1335             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    1340                 1345                 1350             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    1355                 1360                 1365             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    1370                 1375                 1380             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    1385                 1390                 1395             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    1400                 1405                 1410             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    1415                 1420                 1425             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    1430                 1435                 1440             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    1445                 1450                 1455             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    1460                 1465                 1470             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    1475                 1480                 1485             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    1490                 1495                 1500             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    1505                 1510                 1515             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    1520                 1525                 1530             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    1535                 1540                 1545             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    1550                 1555                 1560             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    1565                 1570                 1575             


Pro Arg  Asn Pro Ile Pro Gly  Ile Gly Ala Leu Val  Pro Ala Pro 
    1580                 1585                 1590             


Val Val  Ile Ala Ala Gly Arg  Thr Glu Glu Pro Ile  Ala Ile Val 
    1595                 1600                 1605             


Ser Met  Ala Cys Arg Leu Pro  Gly Gly Val Asn Thr  Pro Gln Arg 
    1610                 1615                 1620             


Leu Trp  Glu Leu Leu Arg Glu  Gly Gly Glu Thr Leu  Ser Gly Phe 
    1625                 1630                 1635             


Pro Thr  Asp Arg Gly Trp Asp  Leu Ala Arg Leu His  His Pro Asp 
    1640                 1645                 1650             


Pro Asp  Asn Pro Gly Thr Ser  Tyr Val Asp Lys Gly  Gly Phe Leu 
    1655                 1660                 1665             


Asp Asp  Ala Ala Gly Phe Asp  Ala Glu Phe Phe Gly  Val Ser Pro 
    1670                 1675                 1680             


Arg Glu  Ala Ala Ala Met Asp  Pro Gln Gln Arg Leu  Leu Leu Glu 
    1685                 1690                 1695             


Thr Ser  Trp Glu Leu Val Glu  Asn Ala Gly Ile Asp  Pro His Ser 
    1700                 1705                 1710             


Leu Arg  Gly Thr Ala Thr Gly  Val Phe Leu Gly Val  Ala Lys Phe 
    1715                 1720                 1725             


Gly Tyr  Gly Glu Asp Thr Ala  Ala Ala Glu Asp Val  Glu Gly Tyr 
    1730                 1735                 1740             


Ser Val  Thr Gly Val Ala Pro  Ala Val Ala Ser Gly  Arg Ile Ser 
    1745                 1750                 1755             


Tyr Thr  Met Gly Leu Glu Gly  Pro Ser Ile Ser Val  Asp Thr Ala 
    1760                 1765                 1770             


Cys Ser  Ser Ser Leu Val Ala  Leu His Leu Ala Val  Glu Ser Leu 
    1775                 1780                 1785             


Arg Lys  Gly Glu Ser Ser Met  Ala Val Val Gly Gly  Ala Ala Val 
    1790                 1795                 1800             


Met Ala  Thr Pro Gly Val Phe  Val Asp Phe Ser Arg  Gln Arg Ala 
    1805                 1810                 1815             


Leu Ala  Ala Asp Gly Arg Ser  Lys Ala Phe Gly Ala  Gly Ala Asp 
    1820                 1825                 1830             


Gly Phe  Gly Phe Ser Glu Gly  Val Thr Leu Val Leu  Leu Glu Arg 
    1835                 1840                 1845             


Leu Ser  Glu Ala Arg Arg Asn  Gly His Glu Val Leu  Ala Val Val 
    1850                 1855                 1860             


Arg Gly  Ser Ala Leu Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Ser 
    1865                 1870                 1875             


Ala Pro  Ser Gly Pro Ala Gln  Arg Arg Val Ile Arg  Gln Ala Leu 
    1880                 1885                 1890             


Glu Ser  Cys Gly Leu Glu Pro  Gly Asp Val Asp Ala  Val Glu Ala 
    1895                 1900                 1905             


His Gly  Thr Gly Thr Ala Leu  Gly Asp Pro Ile Glu  Ala Asn Ala 
    1910                 1915                 1920             


Leu Leu  Asp Thr Tyr Gly Arg  Asp Arg Asp Ala Asp  Arg Pro Leu 
    1925                 1930                 1935             


Trp Leu  Gly Ser Val Lys Ser  Asn Ile Gly His Thr  Gln Ala Ala 
    1940                 1945                 1950             


Ala Gly  Val Thr Gly Leu Leu  Lys Val Val Leu Ala  Leu Arg Asn 
    1955                 1960                 1965             


Gly Glu  Leu Pro Ala Thr Leu  His Val Glu Glu Pro  Thr Pro His 
    1970                 1975                 1980             


Val Asp  Trp Ser Ser Gly Gly  Val Ala Leu Leu Ala  Gly Asn Gln 
    1985                 1990                 1995             


Pro Trp  Arg Arg Gly Glu Arg  Thr Arg Arg Ala Ala  Val Ser Ala 
    2000                 2005                 2010             


Phe Gly  Ile Ser Gly Thr Asn  Ala His Val Ile Val  Glu Glu Ala 
    2015                 2020                 2025             


Pro Gln  Glu Val Arg Pro Ala  Pro Gly Gln Gly Leu  Ser Pro Ala 
    2030                 2035                 2040             


Val Ser  Thr Leu Val Val Ala  Gly Lys Thr Met Gln  Arg Val Ser 
    2045                 2050                 2055             


Ala Thr  Ala Gly Met Leu Ala  Asp Trp Met Glu Gly  Pro Gly Ala 
    2060                 2065                 2070             


Asp Val  Ala Leu Ala Asp Val  Ala His Thr Leu Asn  His His Arg 
    2075                 2080                 2085             


Ser Arg  Gln Pro Lys Phe Gly  Thr Val Val Ala Arg  Asp Arg Thr 
    2090                 2095                 2100             


Gln Ala  Ile Ala Gly Leu Arg  Ala Leu Ala Ala Gly  Gln His Ala 
    2105                 2110                 2115             


Pro Gly  Val Val Asn Pro Ala  Glu Gly Ser Pro Gly  Pro Gly Thr 
    2120                 2125                 2130             


Val Phe  Val Phe Pro Gly Gln  Gly Ser Gln Arg Ala  Gly Met Gly 
    2135                 2140                 2145             


Glu Glu  Leu Ala Ala Ala Phe  Pro Val Phe Ala Arg  Ile His Gln 
    2150                 2155                 2160             


Gln Val  Trp Asp Leu Leu Asp  Val Pro Asp Leu Asp  Val Asn Glu 
    2165                 2170                 2175             


Thr Gly  Tyr Ala Gln Pro Ala  Leu Phe Ala Leu Gln  Val Ala Leu 
    2180                 2185                 2190             


Phe Gly  Leu Leu Glu Ser Trp  Gly Val Arg Pro Asp  Ala Val Val 
    2195                 2200                 2205             


Gly His  Ser Val Gly Glu Leu  Ala Ala Gly Tyr Val  Ser Gly Leu 
    2210                 2215                 2220             


Trp Ser  Leu Glu Asp Ala Cys  Thr Leu Val Ser Ala  Arg Ala Arg 
    2225                 2230                 2235             


Leu Met  Gln Ala Leu Pro Ala  Gly Gly Val Met Ala  Ala Val Pro 
    2240                 2245                 2250             


Val Ser  Glu Asp Glu Ala Arg  Ala Val Leu Gly Glu  Gly Val Glu 
    2255                 2260                 2265             


Ile Ala  Ala Val Asn Gly Pro  Ser Ser Val Val Leu  Ser Gly Asp 
    2270                 2275                 2280             


Glu Ala  Ala Val Leu Gln Ala  Ala Glu Gly Leu Gly  Lys Trp Thr 
    2285                 2290                 2295             


Arg Leu  Pro Thr Ser His Ala  Phe His Ser Ala Arg  Met Glu Pro 
    2300                 2305                 2310             


Met Leu  Glu Glu Phe Arg Ala  Val Ala Glu Gly Leu  Thr Tyr Arg 
    2315                 2320                 2325             


Thr Pro  Gln Val Ala Met Ala  Ala Gly Asp Gln Val  Met Thr Ala 
    2330                 2335                 2340             


Glu Tyr  Trp Val Arg Gln Val  Arg Asp Thr Val Arg  Phe Gly Glu 
    2345                 2350                 2355             


Gln Val  Ala Ser Phe Glu Asp  Ala Val Phe Val Glu  Leu Gly Ala 
    2360                 2365                 2370             


Asp Arg  Ser Leu Ala Arg Leu  Val Asp Gly Ile Ala  Met Leu His 
    2375                 2380                 2385             


Gly Asp  His Glu Ala Gln Ala  Gly Met Arg Arg Glu  Gln Pro Leu 
    2390                 2395                 2400             


Pro Leu  Gly Leu Arg Arg Leu  Leu Thr Asp Leu His  Asn Ala Gly 
    2405                 2410                 2415             


Ala Ala  Val Asp Phe Ser Val  Leu Cys Pro Gln Gly  Arg Leu Val 
    2420                 2425                 2430             


Asp Ala  Pro Leu Pro Ala Trp  Ser His Arg Phe Leu  Phe Tyr Asp 
    2435                 2440                 2445             


Arg Glu  Gly Val Asp Asn Arg  Ser Pro Gly Gly Ser  Thr Val Ala 
    2450                 2455                 2460             


Val His  Pro Leu Leu Leu Ala  Ala Val Asp Val Pro  Gly His Gly 
    2465                 2470                 2475             


Gly Ala  Val Phe Thr Gly Arg  Leu Ser Thr Asp Glu  Gln Pro Trp 
    2480                 2485                 2490             


Leu Ala  Glu His Val Val Gly  Gly Arg Thr Leu Val  Pro Gly Ser 
    2495                 2500                 2505             


Val Leu  Val Asp Leu Ala Leu  Ala Ala Gly Glu Asp  Val Gly Leu 
    2510                 2515                 2520             


Pro Val  Leu Glu Glu Leu Val  Leu Gln Arg Pro Leu  Val Leu Ala 
    2525                 2530                 2535             


Gly Ala  Gly Ala Leu Leu Arg  Met Ser Val Gly Ala  Pro Asp Glu 
    2540                 2545                 2550             


Ser Gly  Arg Arg Thr Ile Asp  Val His Ala Ala Glu  Asp Val Ala 
    2555                 2560                 2565             


Asp Leu  Ala Asp Ala Gln Trp  Ser Gln His Ala Thr  Gly Thr Leu 
    2570                 2575                 2580             


Ala Gln  Gly Val Ala Ala Gly  Pro Arg Asp Thr Glu  Gln Trp Pro 
    2585                 2590                 2595             


Pro Glu  Asp Ala Val Arg Ile  Pro Leu Asp Asp His  Tyr Asp Gly 
    2600                 2605                 2610             


Leu Ala  Glu Gln Gly Tyr Glu  Tyr Gly Pro Ser Phe  Gln Ala Leu 
    2615                 2620                 2625             


Val Ala  Tyr Val Ala Glu Asp  Ala Thr Ala Thr Met  Leu Ala Glu 
    2630                 2635                 2640             


Val Ala  Leu Pro Gly Ser Ile  Arg Ser Gln Gln Gly  Leu Tyr Ala 
    2645                 2650                 2655             


Ile His  Pro Ala Leu Leu Asp  Ala Cys Phe Gln Ser  Val Gly Ala 
    2660                 2665                 2670             


His Pro  Asp Ser Gln Ser Val  Gly Ser Gly Leu Leu  Val Pro Leu 
    2675                 2680                 2685             


Gly Val  Arg Arg Val Arg Ala  Tyr Ala Pro Val Arg  Thr Ala Arg 
    2690                 2695                 2700             


Tyr Cys  Tyr Thr Arg Val Thr  Lys Val Glu Leu Ala  Gly Val Glu 
    2705                 2710                 2715             


Ala Asp  Ile Asp Val Leu Asp  Ala His Gly Thr Val  Leu Leu Ala 
    2720                 2725                 2730             


Val Cys  Gly Leu Arg Ile Gly  Thr Gly Val Ser Glu  Arg Asp Lys 
    2735                 2740                 2745             


His Asn  Arg Val Leu Asn Glu  Arg Leu Leu Thr Ile  Glu Trp His 
    2750                 2755                 2760             


Gln Arg  Glu Leu Pro Glu Met  Asp Pro Ser Gly Ala  Gly Lys Trp 
    2765                 2770                 2775             


Leu Leu  Ile Ser Asp Cys Ala  Ala Ser Asp Val Thr  Ala Thr Arg 
    2780                 2785                 2790             


Leu Ala  Asp Ala Phe Arg Glu  His Ser Ala Ala Cys  Thr Thr Met 
    2795                 2800                 2805             


Arg Trp  Pro Leu His Asp Asp  Gln Leu Ala Ala Ala  Asp Gln Leu 
    2810                 2815                 2820             


Arg Asp  Gln Val Gly Ser Asp  Glu Phe Ser Gly Val  Val Val Leu 
    2825                 2830                 2835             


Thr Gly  Pro Asn Thr Gly Thr  Pro His Gln Gly Ser  Ala Asp Arg 
    2840                 2845                 2850             


Gly Ala  Glu Tyr Val Arg Arg  Leu Val Gly Ile Ala  Arg Glu Leu 
    2855                 2860                 2865             


Ser Asp  Leu Pro Gly Ala Val  Pro Arg Met Tyr Val  Val Thr Arg 
    2870                 2875                 2880             


Gly Ala  Gln Arg Val Leu Ala  Asp Asp Cys Val Asn  Leu Glu Gln 
    2885                 2890                 2895             


Gly Gly  Leu Arg Gly Leu Leu  Arg Thr Ile Gly Ala  Glu His Pro 
    2900                 2905                 2910             


His Leu  Arg Ala Thr Gln Ile  Asp Val Asp Glu Gln  Thr Gly Val 
    2915                 2920                 2925             


Glu Gln  Leu Ala Arg Gln Leu  Leu Ala Thr Ser Glu  Glu Asp Glu 
    2930                 2935                 2940             


Thr Ala  Trp Arg Asp Asn Glu  Trp Tyr Val Ala Arg  Leu Cys Pro 
    2945                 2950                 2955             


Thr Pro  Leu Arg Pro Gln Glu  Arg Arg Thr Ile Val  Ala Asp His 
    2960                 2965                 2970             


Gln Gln  Ser Gly Met Arg Leu  Gln Ile Arg Thr Pro  Gly Ala Ile 
    2975                 2980                 2985             


Asp Ser  Val Ala Phe Glu Pro  Ala Pro Asp Val Glu  Gln Pro Leu 
    2990                 2995                 3000             


Arg Ala  Gly Glu Val Arg Val  Asp Val Arg Ala Thr  Gly Val Asn 
    3005                 3010                 3015             


Phe Arg  Asp Val Leu Leu Ala  Leu Gly Met Tyr Pro  Gln Lys Ala 
    3020                 3025                 3030             


Asp Met  Gly Thr Glu Ala Ala  Gly Val Val Thr Ala  Val Gly Pro 
    3035                 3040                 3045             


Asp Val  Asp Ala Phe Ala Pro  Gly Asp Arg Val Leu  Gly Leu Phe 
    3050                 3055                 3060             


Gln Gly  Ala Phe Ala Pro Ile  Ala Val Thr Asp His  Arg Leu Leu 
    3065                 3070                 3075             


Ala Arg  Val Pro Asp Gly Trp  Ser Asp Ala Asp Ala  Ala Ala Val 
    3080                 3085                 3090             


Pro Ile  Ala Tyr Thr Thr Ala  His Tyr Ala Leu His  Asp Leu Ala 
    3095                 3100                 3105             


Gly Leu  Arg Ala Gly Gln Ser  Val Leu Ile His Ala  Ala Ala Gly 
    3110                 3115                 3120             


Gly Val  Gly Met Ala Ala Val  Ala Leu Ala Arg Arg  Ala Gly Ala 
    3125                 3130                 3135             


Glu Val  Leu Ala Thr Ala Gly  Pro Ala Lys His Gly  Thr Leu Arg 
    3140                 3145                 3150             


Ala Leu  Gly Leu Asp Asp Glu  His Ile Ala Ser Ser  Arg Glu Thr 
    3155                 3160                 3165             


Gly Phe  Ala Arg Lys Phe Arg  Glu Arg Thr Gly Gly  Arg Gly Val 
    3170                 3175                 3180             


Asp Val  Val Leu Asn Ser Leu  Thr Gly Glu Leu Leu  Asp Glu Ser 
    3185                 3190                 3195             


Ala Asp  Leu Leu Ala Glu Asp  Gly Val Phe Val Glu  Met Gly Lys 
    3200                 3205                 3210             


Thr Asp  Leu Arg Asp Ala Gly  Asp Phe Arg Gly Arg  Tyr Ala Pro 
    3215                 3220                 3225             


Phe Asp  Leu Gly Glu Ala Gly  Asp Asp Arg Leu Gly  Glu Ile Leu 
    3230                 3235                 3240             


Arg Glu  Val Val Gly Leu Leu  Gly Ala Gly Glu Leu  Asp Arg Leu 
    3245                 3250                 3255             


Pro Val  Ser Ala Trp Glu Leu  Gly Ile Pro Gln Thr  Gly Lys Ser 
    3260                 3265                 3270             


Leu Val  Thr Leu Pro Pro Glu  Gln Ala Gln Val Phe  Arg Pro Asp 
    3275                 3280                 3285             


Gly Thr  Val Leu Ile Thr Gly  Gly Thr Gly Thr Leu  Gly Arg Leu 
    3290                 3295                 3300             


Leu Ala  Arg His Leu Val Thr  Glu His Gly Val Arg  His Leu Leu 
    3305                 3310                 3315             


Leu Val  Ser Arg Arg Gly Ala  Asp Ala Pro Gly Ser  Asp Glu Leu 
    3320                 3325                 3330             


Arg Ala  Glu Ile Glu Asp Leu  Gly Ala Ser Ala Glu  Ile Ala Ala 
    3335                 3340                 3345             


Cys Asp  Thr Ala Asp Arg Asp  Ala Leu Ser Ala Leu  Leu Asp Gly 
    3350                 3355                 3360             


Leu Pro  Arg Pro Leu Thr Gly  Val Val His Ala Ala  Gly Val Leu 
    3365                 3370                 3375             


Ala Asp  Gly Leu Val Thr Ser  Ile Asp Glu Pro Ala  Val Glu Gln 
    3380                 3385                 3390             


Val Leu  Arg Ala Lys Val Asp  Ala Ala Trp Asn Leu  His Glu Leu 
    3395                 3400                 3405             


Thr Ala  Asn Thr Gly Leu Ser  Phe Phe Val Leu Phe  Ser Ser Ala 
    3410                 3415                 3420             


Ala Ser  Val Leu Ala Gly Pro  Gly Gln Gly Val Tyr  Ala Ala Ala 
    3425                 3430                 3435             


Asn Glu  Ser Leu Asn Ala Leu  Ala Ala Leu Arg Arg  Thr Arg Gly 
    3440                 3445                 3450             


Leu Pro  Ala Lys Ala Leu Gly  Trp Gly Leu Trp Ala  Ile Gly Arg 
    3455                 3460                 3465             


Ala Ile  Ala Phe Ala Glu Gln  Thr Gly Asp Ala Ile  Ala Pro Glu 
    3470                 3475                 3480             


Glu Gly  Ala Tyr Ala Phe Glu  Thr Leu Leu Arg His  Asn Arg Ala 
    3485                 3490                 3495             


Tyr Ser  Gly Tyr Ala Pro Val  Ile Gly Ser Pro Trp  Leu Thr Ala 
    3500                 3505                 3510             


Phe Ala  Gln His Ser Pro Phe  Ala Glu Lys Phe Gln  Ser Leu Gly 
    3515                 3520                 3525             


Gln Asn  Arg Ser Gly Thr Ser  Lys Phe Leu Ala Glu  Leu Val Asp 
    3530                 3535                 3540             


Leu Pro  Arg Glu Glu Trp Pro  Asp Arg Leu Arg Arg  Leu Leu Glu 
    3545                 3550                 3555             


Leu Val  Arg Ser His Ala Ala  Ala Val Ser Gly Tyr  Gly Ser Ala 
    3560                 3565                 3570             


Asp Gln  Leu Pro Glu Arg Lys  Ala Phe Lys Asp Leu  Gly Phe Asp 
    3575                 3580                 3585             


Ser Leu  Ala Ala Val Glu Leu  Arg Asn Arg Leu Gly  Thr Ala Thr 
    3590                 3595                 3600             


Gly Val  Arg Leu Pro Ser Thr  Leu Val Phe Asp His  Pro Thr Pro 
    3605                 3610                 3615             


Leu Ala  Val Ala Glu His Leu  Arg Asp Arg Leu Thr  Ser Gly Glu 
    3620                 3625                 3630             


Asp Asn  Pro Ile Pro Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser 
    3635                 3640                 3645             


Thr Trp  Leu Arg Arg Phe Gly  Pro Pro Val Glu His  Arg Ala Arg 
    3650                 3655                 3660             


Leu Val  Cys Phe Pro His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu 
    3665                 3670                 3675             


Asp Leu  Ala Arg Ala Leu Ala  Pro Glu Ile Asp Val  His Ala Val 
    3680                 3685                 3690             


Gln Tyr  Pro Gly Arg Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly 
    3695                 3700                 3705             


Thr Ala  Gly Glu Ile Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala 
    3710                 3715                 3720             


Ser Gly  Gly Asp Gly Pro Phe  Ala Leu Phe Gly His  Ser Met Gly 
    3725                 3730                 3735             


Ala Leu  Ile Ala Tyr Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro 
    3740                 3745                 3750             


Gly Gly  Gly Pro Leu Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro 
    3755                 3760                 3765             


Arg Val  His Glu Arg Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu 
    3770                 3775                 3780             


Val Asp  Glu Leu Arg Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala 
    3785                 3790                 3795             


Asp Glu  Ala Leu Leu Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp 
    3800                 3805                 3810             


Tyr Arg  Val Leu Arg Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu 
    3815                 3820                 3825             


Arg Ala  Gly Ile Thr Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr 
    3830                 3835                 3840             


Ala Thr  Gly Asp Ala Glu Arg  Trp Leu Gln His Ser  Val Ile Pro 
    3845                 3850                 3855             


Gly Arg  Thr Arg Thr Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu 
    3860                 3865                 3870             


Gln Val  Thr Glu Val Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg 
    3875                 3880                 3885             


Ala Gly  Leu Ala Gly 
    3890             


<210>  120
<211>  11598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-MalOH

<400>  120
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctacc tggaattggg gcgctagttc ccgctcccgt ggtaatcgca     6360

gcaggccgta cggaggaacc aattgccatc gtttcgatgg catgtcgttt accgggagga     6420

gtcaatacgc cccaacggct ctgggaatta ctacgggagg gtggtgaaac cttgtccggg     6480

ttcccaacgg accgtggctg ggacctagca cggcttcacc accctgatcc ggacaacccc     6540

ggaacgagct acgttgataa gggtggattt ctcgacgacg cggcgggttt cgacgcagag     6600

tttttcgggg tttcaccaag ggaagctgcc gctatggacc ctcagcaacg attactttta     6660

gagacctcgt gggagctagt tgaaaatgcg ggcatagatc cacatagcct gcgagggaca     6720

gcgacagggg tgttcctagg agttgcgaag tttggttatg gtgaggacac agcagcagcg     6780

gaagatgttg aaggttattc agttaccggt gttgctcccg ctgtggcatc tggccgcata     6840

tcctacacta tgggtttaga aggtccttcc atctcggtcg ataccgcatg ctcaagctcg     6900

ctagtcgcgc ttcatctagc cgtagagtcc ctccgaaagg gtgagtcatc tatggcggtg     6960

gtgggtggtg cagccgttat ggcgactcct ggggtatttg ttgatttttc acgccaacgg     7020

gcgcttgccg cagacggccg ttccaaagcg ttcggggcag gtgcagatgg ttttggtttc     7080

agcgagggag tcacgctggt tctactagag cgtttaagtg aggcgcgtcg taacggtcat     7140

gaagttctag ctgtagtgcg cgggtccgcg ttaaaccagg acggagcgag caacggactt     7200

tcagcaccct ccggccctgc gcaacgtaga gtaataaggc aagcgctcga atcgtgtggg     7260

cttgaaccgg gggatgttga cgcggttgag gcgcatggta ctggtacagc actaggtgac     7320

ccaatagagg ccaatgcgct gttggacact tacgggcgag accgtgatgc ggatcgtcca     7380

ctttggttgg ggtccgttaa gagcaatatt gggcacactc aagctgcggc cggggttaca     7440

ggactgctga aggttgtgtt agcactgcgc aatggtgagc tacctgcaac gttacatgtc     7500

gaggaaccaa ctccacacgt cgattggtcc tcaggtggtg tcgcattact ggcgggtaat     7560

caaccatggc gaaggggaga aaggaccaga agggcggcag tgagcgcctt tggtatctcc     7620

ggtacaaatg ctcacgtgat agtggaagag gcgcctcagg aagttcgacc cgcccctggc     7680

caagggctgt cgccagccgt gtccacgtta gttgttgcag gtaaaaccat gcagcgtgta     7740

agtgcgacag ctggaatgct tgcagactgg atggagggtc ctggggccga tgttgcattg     7800

gcggatgtgg cccataccct gaaccatcac cgatcaagac agcccaagtt cgggacggtt     7860

gtagcgcgtg acaggactca ggcgatagct gggctccgtg cattggcggc tggtcaacat     7920

gctcctgggg tcgtcaaccc agctgaaggt tccccaggac caggcaccgt gttcgttttt     7980

cccggtcaag gttcgcagag ggcagggatg ggggaggaac tcgcggcagc ctttcctgtc     8040

ttcgctcgaa tacatcagca agtttgggac ctcctagatg ttcccgacct cgacgttaat     8100

gaaaccgggt acgcccaacc agcgctgttc gcgcttcagg tcgcgctctt tggccttctg     8160

gagtcgtggg gtgttaggcc agatgcagtg gtagggcact cagttggtga gctggccgcg     8220

gggtacgtgt ccggtctttg gtcactagag gacgcctgca cactagtctc agcaagagcg     8280

cgcctaatgc aggcactgcc tgctggaggg gtgatggcgg cagtccccgt ctccgaggat     8340

gaggcgcggg ccgtcctggg cgagggagtt gaaattgcgg ctgtgaatgg accctcgtcc     8400

gttgtgctct caggggacga ggcggcagtc ttacaggccg ccgaaggtct aggtaagtgg     8460

acgcgactgc cgaccagcca tgcttttcac tcagcgagaa tggaacccat gctagaagag     8520

tttcgggccg tagcagaggg tctgacctat cgtacccctc aagtagctat ggctgctggg     8580

gatcaggtga tgacagcaga atattgggtg cggcaggttc gggacacagt tcgcttcggg     8640

gagcaagtag cgtcattcga ggatgcggtg tttgttgagt taggcgctga cagaagtcta     8700

gcgcgtttgg tggacggcat cgccatgctg cacggtgacc acgaagcgca ggccgcggac     8760

cataggcaaa tcaccgaagc ggttgcggat gcttacgtct taggccacct tccggatttt     8820

gcggcgctgc ggcggcctca cgcacgaaag ttggacttac caacttatcc cttcgagcgt     8880

agacagtact ggttcagaga tgcgcgtgag aggccggaac aacccagaga taccggcgga     8940

cctcgcacag aagcagtccg tctgttagag gatggtagga ttgaagaatt agctgcactt     9000

ttgggagggg ccagtgatga ccaacacaca ttacaggtgc tgactaagtt ggcggcgcaa     9060

cataaccaac aacgaacaac ccggtcaatc gctgacgaca ggtacgaaat aaggtgggac     9120

cgatcgactt ccccactatc cggagcagat gttgaccaag cggggagctg gatcgtggtg     9180

tcagatgacg cagatgccgt tcccccgcta gtggacttgc tggctgcacg taacgagccc     9240

catcaggttg ttggtctacc cgcttcggac gcagacgagg agaggctcgc agagactctg     9300

cgtgcggctg cgactgaaga tgctaccctt cggatagtcc acgttgcggc gctcgaagca     9360

ggcgctaccc ccagcatgcg ttcactgctc cgcatgcagc accgaatact aggtggcacg     9420

cggcgggtgt tcagggcagc ggtcgcagcg gagttaagag gtcccatttg gatagtgacg     9480

cggggagcac aaagagtggc tgacaccgat acagttgccc cgcatcagtc atgcctctgg     9540

ggatttggga gggcagcatc gctggagctg ccgcacgttt ggggtggcct agcagattta     9600

tcagagggcg gtgacaatgc ggccgatgag tggagtgcgc tagtggaccg cattgccgca     9660

ccccacggtt cagcagttag ggaggaccaa ctggcgctga gagacagggc cgtatatacg     9720

ccaagactgg ccagacgttc tgcgcccccg agcgggactc ccctacatct acgaggggat     9780

ggcacagtgt taataacagg tgggactggt acactaggta ggctattagc gcgtcaccta     9840

gtaacagagc atggggtgcg gcatctctta ctagtttcaa ggagaggcgc cgatgcccct     9900

ggctcggatg aactgcgcgc agaaatagag gacttaggtg ccagcgcgga gatcgcagcg     9960

tgtgatacag cggatcgcga tgccctatct gccctactag atggtctccc ccggcccctt    10020

acgggtgtcg ttcacgccgc tggcgtgtta gccgatggac ttgtcactag cattgacgag    10080

cctgcggtgg aacaggttct ccgagcaaag gtggacgcgg catggaacct acacgaactc    10140

acagctaata ccgggctatc ctttttcgtt cttttctcat cagcagcatc ggtcctggca    10200

ggtccagggc aaggagttta tgcggctgca aatgaatcgc tcaacgcact agctgcgtta    10260

aggcgaacta ggggtctgcc ggccaaggct ctgggatggg gcctgtgggc catcgggcgg    10320

gcaatcgctt ttgcggagca gaccggggac gccatcgctc cagaggaagg agcatacgct    10380

tttgaaactc tgttaaggca taaccgtgcc tactcgggat atgcgcccgt cattggatct    10440

ccctggttga ccgcgttcgc acagcattcc ccctttgcag aaaaattcca atcactcgga    10500

cagaatcggt cagggacatc gaaattctta gcggagctag ttgacctgcc tcgtgaggaa    10560

tggccggata ggctcaggag actactagag ttagttaggt cccatgccgc cgcggtctcc    10620

ggttacggta gtgcagatca actgccggaa agaaaagcgt tcaaggattt ggggtttgat    10680

tcgctggccg ccgttgaact gcgtaaccgg ctgggaacgg ctacaggggt acgactgccg    10740

tcaaccctag tatttgatca cccaactccg ctggccgtcg ctgagcactt aagagatagg    10800

ctaacatccg gggaagataa ccctatcccc ctatgtcaag gcgatgggga ggagatgagc    10860

acatggctac gtcgttttgg acccccagtc gaacatcggg ccaggctagt gtgtttcccc    10920

cacgcaggcg cagcggcgga ttcatactta gacctagcaa gagcgttagc accagagatc    10980

gatgttcatg ctgttcaata ccccggcagg caagacagaa gggacgagga gccattagga    11040

accgcaggtg aaattgcaga tgaagtggca gcggtgctac gtgcgtcggg aggggatggg    11100

ccttttgcac ttttcggcca cagtatgggc gccctcatcg cgtacgagac agcaaggcga    11160

ttagagaggg aaccgggagg gggaccctta cgtttattcg tgagcggaca aacagcgcca    11220

cgtgtccatg aacgaagaac tgatctgccc ggtgacgatg gactcgtgga cgagcttagg    11280

cgacttggca cctccgaggc agcgctcgca gacgaagccc tgctggctat gtctctcccg    11340

gtgctcaggg cggattatag ggtgttaaga tcctacgctt gggcggatgg tcccccacta    11400

cgcgccggta taactgccct ctgcggtgat gcagacccac taactgcaac aggggatgcg    11460

gaacgctggt tacaacattc cgtgattccg ggtcggacac ggacatttcc cggtgggcat    11520

ttttatttag gggaacaagt gaccgaggtg gcaggggctg tccgtagaga tttactgaga    11580

gcagggttag cgggttga                                                  11598


<210>  121
<211>  3865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-MalOH

<400>  121

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Pro Gly Ile Gly  Ala Leu Val Pro Ala  Pro Val Val 
    2105                 2110                 2115             


Ile Ala  Ala Gly Arg Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met 
    2120                 2125                 2130             


Ala Cys  Arg Leu Pro Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp 
    2135                 2140                 2145             


Glu Leu  Leu Arg Glu Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr 
    2150                 2155                 2160             


Asp Arg  Gly Trp Asp Leu Ala  Arg Leu His His Pro  Asp Pro Asp 
    2165                 2170                 2175             


Asn Pro  Gly Thr Ser Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp 
    2180                 2185                 2190             


Ala Ala  Gly Phe Asp Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu 
    2195                 2200                 2205             


Ala Ala  Ala Met Asp Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser 
    2210                 2215                 2220             


Trp Glu  Leu Val Glu Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg 
    2225                 2230                 2235             


Gly Thr  Ala Thr Gly Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr 
    2240                 2245                 2250             


Gly Glu  Asp Thr Ala Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val 
    2255                 2260                 2265             


Thr Gly  Val Ala Pro Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr 
    2270                 2275                 2280             


Met Gly  Leu Glu Gly Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser 
    2285                 2290                 2295             


Ser Ser  Leu Val Ala Leu His  Leu Ala Val Glu Ser  Leu Arg Lys 
    2300                 2305                 2310             


Gly Glu  Ser Ser Met Ala Val  Val Gly Gly Ala Ala  Val Met Ala 
    2315                 2320                 2325             


Thr Pro  Gly Val Phe Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala 
    2330                 2335                 2340             


Ala Asp  Gly Arg Ser Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe 
    2345                 2350                 2355             


Gly Phe  Ser Glu Gly Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser 
    2360                 2365                 2370             


Glu Ala  Arg Arg Asn Gly His  Glu Val Leu Ala Val  Val Arg Gly 
    2375                 2380                 2385             


Ser Ala  Leu Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro 
    2390                 2395                 2400             


Ser Gly  Pro Ala Gln Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser 
    2405                 2410                 2415             


Cys Gly  Leu Glu Pro Gly Asp  Val Asp Ala Val Glu  Ala His Gly 
    2420                 2425                 2430             


Thr Gly  Thr Ala Leu Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu 
    2435                 2440                 2445             


Asp Thr  Tyr Gly Arg Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu 
    2450                 2455                 2460             


Gly Ser  Val Lys Ser Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly 
    2465                 2470                 2475             


Val Thr  Gly Leu Leu Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu 
    2480                 2485                 2490             


Leu Pro  Ala Thr Leu His Val  Glu Glu Pro Thr Pro  His Val Asp 
    2495                 2500                 2505             


Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp 
    2510                 2515                 2520             


Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly 
    2525                 2530                 2535             


Ile Ser  Gly Thr Asn Ala His  Val Ile Val Glu Glu  Ala Pro Gln 
    2540                 2545                 2550             


Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser 
    2555                 2560                 2565             


Thr Leu  Val Val Ala Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr 
    2570                 2575                 2580             


Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val 
    2585                 2590                 2595             


Ala Leu  Ala Asp Val Ala His  Thr Leu Asn His His  Arg Ser Arg 
    2600                 2605                 2610             


Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala 
    2615                 2620                 2625             


Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly 
    2630                 2635                 2640             


Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe 
    2645                 2650                 2655             


Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu 
    2660                 2665                 2670             


Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg Ile His  Gln Gln Val 
    2675                 2680                 2685             


Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly 
    2690                 2695                 2700             


Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly 
    2705                 2710                 2715             


Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp Ala Val  Val Gly His 
    2720                 2725                 2730             


Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser 
    2735                 2740                 2745             


Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met 
    2750                 2755                 2760             


Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala Ala Val  Pro Val Ser 
    2765                 2770                 2775             


Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala 
    2780                 2785                 2790             


Ala Val  Asn Gly Pro Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala 
    2795                 2800                 2805             


Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu 
    2810                 2815                 2820             


Pro Thr  Ser His Ala Phe His  Ser Ala Arg Met Glu  Pro Met Leu 
    2825                 2830                 2835             


Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro 
    2840                 2845                 2850             


Gln Val  Ala Met Ala Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr 
    2855                 2860                 2865             


Trp Val  Arg Gln Val Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val 
    2870                 2875                 2880             


Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg 
    2885                 2890                 2895             


Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala Met Leu  His Gly Asp 
    2900                 2905                 2910             


His Glu  Ala Gln Ala Ala Asp  His Arg Gln Ile Thr  Glu Ala Val 
    2915                 2920                 2925             


Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro Asp Phe  Ala Ala Leu 
    2930                 2935                 2940             


Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu Pro Thr  Tyr Pro Phe 
    2945                 2950                 2955             


Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala Arg Glu  Arg Pro Glu 
    2960                 2965                 2970             


Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr Glu Ala  Val Arg Leu 
    2975                 2980                 2985             


Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala Ala Leu  Leu Gly Gly 
    2990                 2995                 3000             


Ala Ser  Asp Asp Gln His Thr  Leu Gln Val Leu Thr  Lys Leu Ala 
    3005                 3010                 3015             


Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg Ser Ile  Ala Asp Asp 
    3020                 3025                 3030             


Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr Ser Pro  Leu Ser Gly 
    3035                 3040                 3045             


Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile Val Val  Ser Asp Asp 
    3050                 3055                 3060             


Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu Leu Ala  Ala Arg Asn 
    3065                 3070                 3075             


Glu Pro  His Gln Val Val Gly  Leu Pro Ala Ser Asp  Ala Asp Glu 
    3080                 3085                 3090             


Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala Ala Thr  Glu Asp Ala 
    3095                 3100                 3105             


Thr Leu  Arg Ile Val His Val  Ala Ala Leu Glu Ala  Gly Ala Thr 
    3110                 3115                 3120             


Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln His Arg  Ile Leu Gly 
    3125                 3130                 3135             


Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val Ala Ala  Glu Leu Arg 
    3140                 3145                 3150             


Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala Gln Arg  Val Ala Asp 
    3155                 3160                 3165             


Thr Asp  Thr Val Ala Pro His  Gln Ser Cys Leu Trp  Gly Phe Gly 
    3170                 3175                 3180             


Arg Ala  Ala Ser Leu Glu Leu  Pro His Val Trp Gly  Gly Leu Ala 
    3185                 3190                 3195             


Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala Asp Glu  Trp Ser Ala 
    3200                 3205                 3210             


Leu Val  Asp Arg Ile Ala Ala  Pro His Gly Ser Ala  Val Arg Glu 
    3215                 3220                 3225             


Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val Tyr Thr  Pro Arg Leu 
    3230                 3235                 3240             


Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr Pro Leu  His Leu Arg 
    3245                 3250                 3255             


Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly Thr Gly  Thr Leu Gly 
    3260                 3265                 3270             


Arg Leu  Leu Ala Arg His Leu  Val Thr Glu His Gly  Val Arg His 
    3275                 3280                 3285             


Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp Ala Pro  Gly Ser Asp 
    3290                 3295                 3300             


Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly Ala Ser  Ala Glu Ile 
    3305                 3310                 3315             


Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala Leu Ser  Ala Leu Leu 
    3320                 3325                 3330             


Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val Val His  Ala Ala Gly 
    3335                 3340                 3345             


Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile Asp Glu  Pro Ala Val 
    3350                 3355                 3360             


Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala Ala Trp  Asn Leu His 
    3365                 3370                 3375             


Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe Phe Val  Leu Phe Ser 
    3380                 3385                 3390             


Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly Gln Gly  Val Tyr Ala 
    3395                 3400                 3405             


Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala Ala Leu  Arg Arg Thr 
    3410                 3415                 3420             


Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp Gly Leu  Trp Ala Ile 
    3425                 3430                 3435             


Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr Gly Asp  Ala Ile Ala 
    3440                 3445                 3450             


Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr Leu Leu  Arg His Asn 
    3455                 3460                 3465             


Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile Gly Ser  Pro Trp Leu 
    3470                 3475                 3480             


Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala Glu Lys  Phe Gln Ser 
    3485                 3490                 3495             


Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys Phe Leu  Ala Glu Leu 
    3500                 3505                 3510             


Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp Arg Leu  Arg Arg Leu 
    3515                 3520                 3525             


Leu Glu  Leu Val Arg Ser His  Ala Ala Ala Val Ser  Gly Tyr Gly 
    3530                 3535                 3540             


Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala Phe Lys  Asp Leu Gly 
    3545                 3550                 3555             


Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg Asn Arg  Leu Gly Thr 
    3560                 3565                 3570             


Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu Val Phe  Asp His Pro 
    3575                 3580                 3585             


Thr Pro  Leu Ala Val Ala Glu  His Leu Arg Asp Arg  Leu Thr Ser 
    3590                 3595                 3600             


Gly Glu  Asp Asn Pro Ile Pro  Leu Cys Gln Gly Asp  Gly Glu Glu 
    3605                 3610                 3615             


Met Ser  Thr Trp Leu Arg Arg  Phe Gly Pro Pro Val  Glu His Arg 
    3620                 3625                 3630             


Ala Arg  Leu Val Cys Phe Pro  His Ala Gly Ala Ala  Ala Asp Ser 
    3635                 3640                 3645             


Tyr Leu  Asp Leu Ala Arg Ala  Leu Ala Pro Glu Ile  Asp Val His 
    3650                 3655                 3660             


Ala Val  Gln Tyr Pro Gly Arg  Gln Asp Arg Arg Asp  Glu Glu Pro 
    3665                 3670                 3675             


Leu Gly  Thr Ala Gly Glu Ile  Ala Asp Glu Val Ala  Ala Val Leu 
    3680                 3685                 3690             


Arg Ala  Ser Gly Gly Asp Gly  Pro Phe Ala Leu Phe  Gly His Ser 
    3695                 3700                 3705             


Met Gly  Ala Leu Ile Ala Tyr  Glu Thr Ala Arg Arg  Leu Glu Arg 
    3710                 3715                 3720             


Glu Pro  Gly Gly Gly Pro Leu  Arg Leu Phe Val Ser  Gly Gln Thr 
    3725                 3730                 3735             


Ala Pro  Arg Val His Glu Arg  Arg Thr Asp Leu Pro  Gly Asp Asp 
    3740                 3745                 3750             


Gly Leu  Val Asp Glu Leu Arg  Arg Leu Gly Thr Ser  Glu Ala Ala 
    3755                 3760                 3765             


Leu Ala  Asp Glu Ala Leu Leu  Ala Met Ser Leu Pro  Val Leu Arg 
    3770                 3775                 3780             


Ala Asp  Tyr Arg Val Leu Arg  Ser Tyr Ala Trp Ala  Asp Gly Pro 
    3785                 3790                 3795             


Pro Leu  Arg Ala Gly Ile Thr  Ala Leu Cys Gly Asp  Ala Asp Pro 
    3800                 3805                 3810             


Leu Thr  Ala Thr Gly Asp Ala  Glu Arg Trp Leu Gln  His Ser Val 
    3815                 3820                 3825             


Ile Pro  Gly Arg Thr Arg Thr  Phe Pro Gly Gly His  Phe Tyr Leu 
    3830                 3835                 3840             


Gly Glu  Gln Val Thr Glu Val  Ala Gly Ala Val Arg  Arg Asp Leu 
    3845                 3850                 3855             


Leu Arg  Ala Gly Leu Ala Gly  
    3860                 3865 


<210>  122
<211>  13251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-MalH

<400>  122
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctacc tggaattggg gcgctagttc ccgctcccgt ggtaatcgca     6360

gcaggccgta cggaggaacc aattgccata gtatccatgg cttgccggtt acccggtggt     6420

gtgaataccc cacagagact atgggaatta ttacgtgaag ggggagaaac cctcagtggc     6480

ttccctaccg accgagggtg ggacctcgcg aggttgcatc acccagaccc agacaacccc     6540

ggtacgtcat acgttgataa agggggattc ctggacgatg cggcagggtt tgacgcagaa     6600

tttttcggtg tgagccccag agaagcagcg gctatggacc cgcagcagag attactcctc     6660

gaaaccagct gggagttagt cgagaatgca gggattgatc cacatagcct aagggggacc     6720

gccactggtg tcttcctcgg cgttgccaag tttgggtatg gcgaggatac ggcagctgcc     6780

gaagacgtcg aggggtactc tgtcactggt gtagccccgg cagtggcgtc gggcagaatt     6840

agttacacga tggggttgga agggccgtct atttcggttg ataccgcctg ttcctccagt     6900

ctggttgcac tccaccttgc agtcgagtcg ctccggaaag gagaaagcag tatggccgtg     6960

gtcgggggag cggcggtgat ggccacaccg ggtgtgtttg tggatttttc ccgacagaga     7020

gccttggccg cggatgggcg ttcaaaggcg ttcggagcag gtgcagacgg gtttggattt     7080

agcgaaggtg tgacactggt tctcctagaa agattaagtg aagcccggcg taacggccat     7140

gaggtgctgg cagttgttag aggttccgca ttaaaccagg acggggcttc gaacgggctg     7200

agcgccccct cgggcccggc acagagaaga gtgatacgcc aagcactcga atcgtgtggc     7260

ctagaaccag gtgacgttga cgcggtggaa gcgcacggga caggaactgc gttaggggac     7320

ccgatagaag caaacgcctt gctggacact tatggtagag atcgtgatgc ggatcgaccc     7380

ctctggttag gaagtgttaa gtcaaatata ggacacactc aggcagcggc gggagtaact     7440

gggctgctca aagtagtcct agccttacgc aatggggaac tacccgccac cctacatgtc     7500

gaggaaccga caccgcatgt ggattggtcg agcgggggag ttgctctctt ggcgggtaat     7560

cagccgtggc gaagaggtga acgaacccgt agagccgccg tgtccgcatt cgggatcagt     7620

ggtacgaacg cgcacgtgat tgtggaagaa gctccacaag aggtgagacc agcgcccggt     7680

caaggactct cgcccgcggt gtcaaccttg gtagtggcgg gtaaaactat gcagcgtgtt     7740

tcggcaaccg ccggtatgct cgcagattgg atggaaggcc caggtgcaga tgtggcgctg     7800

gcggacgtgg cgcacacgtt aaatcatcac cgttcacggc aaccaaagtt cggtacggtg     7860

gtggccaggg accggacaca ggcaatcgcc ggactaagag cgctggcggc gggtcagcac     7920

gccccagggg ttgttaaccc tgctgaagga agtccaggtc cagggacggt gttcgtgttt     7980

cctggccagg ggtcccagcg tgcaggcatg ggggaggagt tggctgcggc tttccccgtg     8040

tttgccagaa tccaccagca agtgtgggat ttactcgatg ttcctgatct cgacgttaac     8100

gaaacggggt acgcacaacc agcactcttc gcactccaag tggcgctgtt tgggctcctc     8160

gaatcatggg gagtacggcc ggatgccgtg gtcgggcata gtgtagggga attagcggca     8220

gggtacgttt ccgggctttg gagtcttgag gatgcttgca cgctcgtgtc ggcgagagcc     8280

cgtctaatgc aagccttacc ggcaggtggt gttatggcgg cagttccagt gtccgaagac     8340

gaagcacggg ctgtgttggg ggaaggagtc gaaatagctg cggtcaacgg tccgtcgagc     8400

gtggttctaa gcggtgatga agcagcagtg ctccaggccg cggaagggtt aggcaagtgg     8460

acgcgattac cgacctcgca tgcattccat tctgctcgta tggaaccaat gctggaagag     8520

tttagagcag tggcggaagg tctaacatac aggactcccc aggtggcaat ggccgccgga     8580

gaccaggtta tgaccgctga atactgggtg cgtcaggtta gggatacagt tcgttttggc     8640

gagcaagttg cctcgttcga ggatgctgta ttcgtggaat tgggagcaga tcgctctctt     8700

gcacggctag tcgatggtat cgcgatgttg cacggggatc atgaggcaca ggctggtatg     8760

cggagagaac aacccttgcc cttaggttta cgaagattgc taaccgacct gcataacgct     8820

ggtgctgccg tcgattttag tgttttgtgc ccacaaggtc gtctggttga cgcaccgtta     8880

ccagcctggt cacaccggtt tctcttctat gaccgggaag gagtggacaa tagatcacca     8940

gggggaagca cagtggcggt ccacccgctt ttactagccg cggtggatgt gccgggccac     9000

ggtggagcgg ttttcacggg tagactctcg actgacgagc aaccgtggtt agcggagcac     9060

gttgtcgggg gaagaaccct agttcctggt tctgttttag tcgatctagc cttagcggca     9120

ggcgaagacg tagggctacc ggtgttagaa gaattagtat tgcagaggcc gctggtgctt     9180

gccggcgcgg gagcactcct acggatgtcg gtcggggcac cagacgagag cggtagaaga     9240

actatcgatg ttcacgcagc tgaagacgtc gccgatttag cagatgccca atggtcccag     9300

cacgccaccg ggactttagc ccaaggggta gcggcggggc ccagggacac agagcaatgg     9360

cccccagagg atgccgtccg gattccatta gacgaccatt atgatggtct cgcggaacag     9420

ggttatgagt acggtccgtc gtttcaggcg ctagtggcct acgtggcgga ggatgcgact     9480

gcgacaatgt tagcggaagt cgcgcttccg ggcagcatta gatcgcaaca aggtctatac     9540

gccatccatc ccgcactgct ggacgcttgt tttcaatctg tcggagccca cccagacagt     9600

caatccgtcg ggtcaggtct actcgtaccc ctcggtgttc ggagagttcg tgcgtacgca     9660

cccgtaagga ccgcccgtta ttgttacacc cgcgtcacga aagttgaact agctggggtt     9720

gaggccgaca tcgacgttct ggatgctcac ggcacagtgc ttctagccgt gtgcggtctt     9780

cgtatcggga ccggagtgag cgagagggac aaacacaaca gagttctcaa tgagcgccta     9840

ctcaccatcg aatggcatca gcgtgaacta ccagaaatgg acccctcggg tgccgggaag     9900

tggctcctaa tctcggactg tgcagcatcc gatgtcaccg ctacacgact ggctgatgcc     9960

ttccgggagc acagcgctgc gtgcactacc atgcggtggc cacttcacga tgatcaacta    10020

gcagccgccg accaactccg ggaccaggtg ggttcagatg agttttctgg cgtggtagta    10080

ctaacagggc caaacacagg gacccctcat cagggttccg cagaccgtgg cgccgagtac    10140

gttaggcggt tagttggaat cgctcgtgaa cttagcgatc ttcccggagc ggttccccgt    10200

atgtatgtcg tcacaagggg agcgcagaga gtccttgccg atgattgtgt taatttagaa    10260

cagggagggc tcagaggtct gctgaggacc atcggtgctg agcacccaca tctccgcgcc    10320

acccaaattg atgttgatga gcagacagga gtagagcagc tggcgcgaca actcctagct    10380

acatcggagg aagacgagac agcctggagg gacaacgaat ggtacgttgc gaggttatgc    10440

cccacacccc tgaggccaca ggaacgtagg acaatagtgg cggaccatca acagtctggt    10500

atgcggttac aaatacgtac gcccggtgca atcgatagtg tggcctttga acccgcaccc    10560

gatgtagagc aacccttacg ggcgggtgaa gttcgggttg acgttagagc aaccggtgtt    10620

aatttccgtg acgttctact cgctctcggg atgtatcccc agaaagctga catggggaca    10680

gaagcagctg gtgttgtaac agcagtggga cctgatgtcg atgcgtttgc gcctggtgat    10740

agagttctag ggctattcca aggggcattt gctccaattg cggtgactga ccatcgttta    10800

ctggcacggg tgccagacgg gtggtcagat gccgatgcgg cggcggtgcc aatagcttac    10860

acgacagcac attatgcgct gcacgacctg gcggggttgc gggcggggca atctgtcctg    10920

atacacgcgg cagcgggtgg tgttggtatg gccgctgttg cactggcacg gagggccggc    10980

gcagaagttc tggctaccgc aggacctgca aaacacggta cgctacgggc attagggcta    11040

gatgatgaac acatcgcttc gagtcgggag accgggttcg cgcgtaagtt ccgagagcgg    11100

actgggggac gaggagtgga cgtcgttcta aacagcttga ccggcgaact attagacgag    11160

tccgcggatc tcctcgcgga ggacggagtc ttcgtggaaa tgggaaagac tgatctgcgc    11220

gatgcagggg actttcgtgg gcgctacgcc ccgtttgatc taggggaagc aggcgatgac    11280

aggctcgggg aaattctacg tgaggtggtg ggactgctcg gtgcagggga actcgaccga    11340

ctccctgtta gcgcgtggga attggggata ccccagacgg ggaagtcgtt agtgacgctg    11400

ccacccgaac aagcgcaagt tttcagacca gacggcactg tattgatcac cgggggaacg    11460

ggaacgttag gtcggctgct ggcccgtcat ctggttacag agcacggggt gcgtcacctg    11520

ctgctagtgt cgaggagagg agcagatgcc cctggatcgg acgagctgag ggccgaaatc    11580

gaggatctcg gagcatcagc ggaaattgca gcatgtgata cagccgatcg agacgctctc    11640

agcgcgttgc tagatggact gccgaggcca ctgaccggag tagttcacgc cgcgggagtc    11700

ctcgctgacg gtctggttac atccatcgac gagcccgcag tcgaacaagt tctccgtgca    11760

aaagttgatg cggcctggaa cctgcacgag ctaactgcga acaccggtct cagctttttc    11820

gtgctgttct cgtcagccgc aagtgtgtta gcggggccgg ggcagggagt atatgcggca    11880

gcgaacgaat ctttaaacgc tctggccgct ctgcgtagga ctaggggttt acccgcaaaa    11940

gcattgggat ggggattatg ggcgataggg cgtgcaatag catttgccga gcagaccggt    12000

gacgcaatcg ccccggagga aggcgcgtac gccttcgaga cactactcag acataacagg    12060

gcgtactcgg gttacgctcc cgtgataggg tcaccatggc tgactgcgtt cgcccaacat    12120

tcgccctttg cggagaagtt ccagtccctg gggcaaaata gatccgggac gtctaagttt    12180

ctggcagaat tagtcgatct gccaagagaa gaatggccag atcggttacg tcgtctatta    12240

gaactggtga ggtctcatgc tgccgcagtt tcggggtatg gatcggcaga ccaattacca    12300

gaaagaaaag cattcaaaga cctcggattc gattcactgg cagcagtcga actaagaaat    12360

cgtctaggga ccgcgacagg cgtccggctg cccagtactc tggtgttcga ccacccaacc    12420

ccacttgcgg ttgcggaaca tctacgtgat cgtctaacat ccggggaaga taaccctatc    12480

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    12540

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    12600

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    12660

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    12720

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    12780

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    12840

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    12900

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    12960

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    13020

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    13080

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    13140

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    13200

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             13251


<210>  123
<211>  4416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-MalH

<400>  123

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Pro Gly Ile Gly  Ala Leu Val Pro Ala  Pro Val Val 
    2105                 2110                 2115             


Ile Ala  Ala Gly Arg Thr Glu  Glu Pro Ile Ala Ile  Val Ser Met 
    2120                 2125                 2130             


Ala Cys  Arg Leu Pro Gly Gly  Val Asn Thr Pro Gln  Arg Leu Trp 
    2135                 2140                 2145             


Glu Leu  Leu Arg Glu Gly Gly  Glu Thr Leu Ser Gly  Phe Pro Thr 
    2150                 2155                 2160             


Asp Arg  Gly Trp Asp Leu Ala  Arg Leu His His Pro  Asp Pro Asp 
    2165                 2170                 2175             


Asn Pro  Gly Thr Ser Tyr Val  Asp Lys Gly Gly Phe  Leu Asp Asp 
    2180                 2185                 2190             


Ala Ala  Gly Phe Asp Ala Glu  Phe Phe Gly Val Ser  Pro Arg Glu 
    2195                 2200                 2205             


Ala Ala  Ala Met Asp Pro Gln  Gln Arg Leu Leu Leu  Glu Thr Ser 
    2210                 2215                 2220             


Trp Glu  Leu Val Glu Asn Ala  Gly Ile Asp Pro His  Ser Leu Arg 
    2225                 2230                 2235             


Gly Thr  Ala Thr Gly Val Phe  Leu Gly Val Ala Lys  Phe Gly Tyr 
    2240                 2245                 2250             


Gly Glu  Asp Thr Ala Ala Ala  Glu Asp Val Glu Gly  Tyr Ser Val 
    2255                 2260                 2265             


Thr Gly  Val Ala Pro Ala Val  Ala Ser Gly Arg Ile  Ser Tyr Thr 
    2270                 2275                 2280             


Met Gly  Leu Glu Gly Pro Ser  Ile Ser Val Asp Thr  Ala Cys Ser 
    2285                 2290                 2295             


Ser Ser  Leu Val Ala Leu His  Leu Ala Val Glu Ser  Leu Arg Lys 
    2300                 2305                 2310             


Gly Glu  Ser Ser Met Ala Val  Val Gly Gly Ala Ala  Val Met Ala 
    2315                 2320                 2325             


Thr Pro  Gly Val Phe Val Asp  Phe Ser Arg Gln Arg  Ala Leu Ala 
    2330                 2335                 2340             


Ala Asp  Gly Arg Ser Lys Ala  Phe Gly Ala Gly Ala  Asp Gly Phe 
    2345                 2350                 2355             


Gly Phe  Ser Glu Gly Val Thr  Leu Val Leu Leu Glu  Arg Leu Ser 
    2360                 2365                 2370             


Glu Ala  Arg Arg Asn Gly His  Glu Val Leu Ala Val  Val Arg Gly 
    2375                 2380                 2385             


Ser Ala  Leu Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro 
    2390                 2395                 2400             


Ser Gly  Pro Ala Gln Arg Arg  Val Ile Arg Gln Ala  Leu Glu Ser 
    2405                 2410                 2415             


Cys Gly  Leu Glu Pro Gly Asp  Val Asp Ala Val Glu  Ala His Gly 
    2420                 2425                 2430             


Thr Gly  Thr Ala Leu Gly Asp  Pro Ile Glu Ala Asn  Ala Leu Leu 
    2435                 2440                 2445             


Asp Thr  Tyr Gly Arg Asp Arg  Asp Ala Asp Arg Pro  Leu Trp Leu 
    2450                 2455                 2460             


Gly Ser  Val Lys Ser Asn Ile  Gly His Thr Gln Ala  Ala Ala Gly 
    2465                 2470                 2475             


Val Thr  Gly Leu Leu Lys Val  Val Leu Ala Leu Arg  Asn Gly Glu 
    2480                 2485                 2490             


Leu Pro  Ala Thr Leu His Val  Glu Glu Pro Thr Pro  His Val Asp 
    2495                 2500                 2505             


Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala Gly Asn  Gln Pro Trp 
    2510                 2515                 2520             


Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala Val Ser  Ala Phe Gly 
    2525                 2530                 2535             


Ile Ser  Gly Thr Asn Ala His  Val Ile Val Glu Glu  Ala Pro Gln 
    2540                 2545                 2550             


Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu Ser Pro  Ala Val Ser 
    2555                 2560                 2565             


Thr Leu  Val Val Ala Gly Lys  Thr Met Gln Arg Val  Ser Ala Thr 
    2570                 2575                 2580             


Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly Pro Gly  Ala Asp Val 
    2585                 2590                 2595             


Ala Leu  Ala Asp Val Ala His  Thr Leu Asn His His  Arg Ser Arg 
    2600                 2605                 2610             


Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg Asp Arg  Thr Gln Ala 
    2615                 2620                 2625             


Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly Gln His  Ala Pro Gly 
    2630                 2635                 2640             


Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly Pro Gly  Thr Val Phe 
    2645                 2650                 2655             


Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala Gly Met  Gly Glu Glu 
    2660                 2665                 2670             


Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg Ile His  Gln Gln Val 
    2675                 2680                 2685             


Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp Val Asn  Glu Thr Gly 
    2690                 2695                 2700             


Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly 
    2705                 2710                 2715             


Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp Ala Val  Val Gly His 
    2720                 2725                 2730             


Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val Ser Gly  Leu Trp Ser 
    2735                 2740                 2745             


Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala Arg Ala  Arg Leu Met 
    2750                 2755                 2760             


Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala Ala Val  Pro Val Ser 
    2765                 2770                 2775             


Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu Gly Val  Glu Ile Ala 
    2780                 2785                 2790             


Ala Val  Asn Gly Pro Ser Ser  Val Val Leu Ser Gly  Asp Glu Ala 
    2795                 2800                 2805             


Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly Lys Trp  Thr Arg Leu 
    2810                 2815                 2820             


Pro Thr  Ser His Ala Phe His  Ser Ala Arg Met Glu  Pro Met Leu 
    2825                 2830                 2835             


Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu Thr Tyr  Arg Thr Pro 
    2840                 2845                 2850             


Gln Val  Ala Met Ala Ala Gly  Asp Gln Val Met Thr  Ala Glu Tyr 
    2855                 2860                 2865             


Trp Val  Arg Gln Val Arg Asp  Thr Val Arg Phe Gly  Glu Gln Val 
    2870                 2875                 2880             


Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu Leu Gly  Ala Asp Arg 
    2885                 2890                 2895             


Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala Met Leu  His Gly Asp 
    2900                 2905                 2910             


His Glu  Ala Gln Ala Gly Met  Arg Arg Glu Gln Pro  Leu Pro Leu 
    2915                 2920                 2925             


Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His Asn Ala  Gly Ala Ala 
    2930                 2935                 2940             


Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly Arg Leu  Val Asp Ala 
    2945                 2950                 2955             


Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu Phe Tyr  Asp Arg Glu 
    2960                 2965                 2970             


Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser Thr Val  Ala Val His 
    2975                 2980                 2985             


Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro Gly His  Gly Gly Ala 
    2990                 2995                 3000             


Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu Gln Pro  Trp Leu Ala 
    3005                 3010                 3015             


Glu His  Val Val Gly Gly Arg  Thr Leu Val Pro Gly  Ser Val Leu 
    3020                 3025                 3030             


Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp Val Gly  Leu Pro Val 
    3035                 3040                 3045             


Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu Val Leu  Ala Gly Ala 
    3050                 3055                 3060             


Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala Pro Asp  Glu Ser Gly 
    3065                 3070                 3075             


Arg Arg  Thr Ile Asp Val His  Ala Ala Glu Asp Val  Ala Asp Leu 
    3080                 3085                 3090             


Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr Gly Thr  Leu Ala Gln 
    3095                 3100                 3105             


Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu Gln Trp  Pro Pro Glu 
    3110                 3115                 3120             


Asp Ala  Val Arg Ile Pro Leu  Asp Asp His Tyr Asp  Gly Leu Ala 
    3125                 3130                 3135             


Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe Gln Ala  Leu Val Ala 
    3140                 3145                 3150             


Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met Leu Ala  Glu Val Ala 
    3155                 3160                 3165             


Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly Leu Tyr  Ala Ile His 
    3170                 3175                 3180             


Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser Val Gly  Ala His Pro 
    3185                 3190                 3195             


Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu Val Pro  Leu Gly Val 
    3200                 3205                 3210             


Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg Thr Ala  Arg Tyr Cys 
    3215                 3220                 3225             


Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala Gly Val  Glu Ala Asp 
    3230                 3235                 3240             


Ile Asp  Val Leu Asp Ala His  Gly Thr Val Leu Leu  Ala Val Cys 
    3245                 3250                 3255             


Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu Arg Asp  Lys His Asn 
    3260                 3265                 3270             


Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile Glu Trp  His Gln Arg 
    3275                 3280                 3285             


Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala Gly Lys  Trp Leu Leu 
    3290                 3295                 3300             


Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr Ala Thr  Arg Leu Ala 
    3305                 3310                 3315             


Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys Thr Thr  Met Arg Trp 
    3320                 3325                 3330             


Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala Asp Gln  Leu Arg Asp 
    3335                 3340                 3345             


Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val Val Val  Leu Thr Gly 
    3350                 3355                 3360             


Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser Ala Asp  Arg Gly Ala 
    3365                 3370                 3375             


Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala Arg Glu  Leu Ser Asp 
    3380                 3385                 3390             


Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val Val Thr  Arg Gly Ala 
    3395                 3400                 3405             


Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn Leu Glu  Gln Gly Gly 
    3410                 3415                 3420             


Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala Glu His  Pro His Leu 
    3425                 3430                 3435             


Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln Thr Gly  Val Glu Gln 
    3440                 3445                 3450             


Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu Glu Asp  Glu Thr Ala 
    3455                 3460                 3465             


Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg Leu Cys  Pro Thr Pro 
    3470                 3475                 3480             


Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val Ala Asp  His Gln Gln 
    3485                 3490                 3495             


Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro Gly Ala  Ile Asp Ser 
    3500                 3505                 3510             


Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu Gln Pro  Leu Arg Ala 
    3515                 3520                 3525             


Gly Glu  Val Arg Val Asp Val  Arg Ala Thr Gly Val  Asn Phe Arg 
    3530                 3535                 3540             


Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro Gln Lys  Ala Asp Met 
    3545                 3550                 3555             


Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala Val Gly  Pro Asp Val 
    3560                 3565                 3570             


Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu Gly Leu  Phe Gln Gly 
    3575                 3580                 3585             


Ala Phe  Ala Pro Ile Ala Val  Thr Asp His Arg Leu  Leu Ala Arg 
    3590                 3595                 3600             


Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala Ala Ala  Val Pro Ile 
    3605                 3610                 3615             


Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His Asp Leu  Ala Gly Leu 
    3620                 3625                 3630             


Arg Ala  Gly Gln Ser Val Leu  Ile His Ala Ala Ala  Gly Gly Val 
    3635                 3640                 3645             


Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg Ala Gly  Ala Glu Val 
    3650                 3655                 3660             


Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly Thr Leu  Arg Ala Leu 
    3665                 3670                 3675             


Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser Arg Glu  Thr Gly Phe 
    3680                 3685                 3690             


Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly Arg Gly  Val Asp Val 
    3695                 3700                 3705             


Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu Asp Glu  Ser Ala Asp 
    3710                 3715                 3720             


Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu Met Gly  Lys Thr Asp 
    3725                 3730                 3735             


Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg Tyr Ala  Pro Phe Asp 
    3740                 3745                 3750             


Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly Glu Ile  Leu Arg Glu 
    3755                 3760                 3765             


Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu Asp Arg  Leu Pro Val 
    3770                 3775                 3780             


Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr Gly Lys  Ser Leu Val 
    3785                 3790                 3795             


Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe Arg Pro  Asp Gly Thr 
    3800                 3805                 3810             


Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala 
    3815                 3820                 3825             


Arg His  Leu Val Thr Glu His  Gly Val Arg His Leu  Leu Leu Val 
    3830                 3835                 3840             


Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala 
    3845                 3850                 3855             


Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp 
    3860                 3865                 3870             


Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro 
    3875                 3880                 3885             


Arg Pro  Leu Thr Gly Val Val  His Ala Ala Gly Val  Leu Ala Asp 
    3890                 3895                 3900             


Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu 
    3905                 3910                 3915             


Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala 
    3920                 3925                 3930             


Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser 
    3935                 3940                 3945             


Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu 
    3950                 3955                 3960             


Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro 
    3965                 3970                 3975             


Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile 
    3980                 3985                 3990             


Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly 
    3995                 4000                 4005             


Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser 
    4010                 4015                 4020             


Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala 
    4025                 4030                 4035             


Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn 
    4040                 4045                 4050             


Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro 
    4055                 4060                 4065             


Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val 
    4070                 4075                 4080             


Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln 
    4085                 4090                 4095             


Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu 
    4100                 4105                 4110             


Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val 
    4115                 4120                 4125             


Arg Leu  Pro Ser Thr Leu Val  Phe Asp His Pro Thr  Pro Leu Ala 
    4130                 4135                 4140             


Val Ala  Glu His Leu Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn 
    4145                 4150                 4155             


Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp 
    4160                 4165                 4170             


Leu Arg  Arg Phe Gly Pro Pro  Val Glu His Arg Ala  Arg Leu Val 
    4175                 4180                 4185             


Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu 
    4190                 4195                 4200             


Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val His Ala  Val Gln Tyr 
    4205                 4210                 4215             


Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala 
    4220                 4225                 4230             


Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly 
    4235                 4240                 4245             


Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His Ser Met  Gly Ala Leu 
    4250                 4255                 4260             


Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly 
    4265                 4270                 4275             


Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val 
    4280                 4285                 4290             


His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp 
    4295                 4300                 4305             


Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu 
    4310                 4315                 4320             


Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg 
    4325                 4330                 4335             


Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala 
    4340                 4345                 4350             


Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr 
    4355                 4360                 4365             


Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser Val Ile  Pro Gly Arg 
    4370                 4375                 4380             


Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val 
    4385                 4390                 4395             


Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly 
    4400                 4405                 4410             


Leu Ala  Gly 
    4415     


<210>  124
<211>  14904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-MalH

<400>  124
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct acctggaatt     7980

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     8040

atagtatcca tggcttgccg gttacccggt ggtgtgaata ccccacagag actatgggaa     8100

ttattacgtg aagggggaga aaccctcagt ggcttcccta ccgaccgagg gtgggacctc     8160

gcgaggttgc atcacccaga cccagacaac cccggtacgt catacgttga taaaggggga     8220

ttcctggacg atgcggcagg gtttgacgca gaatttttcg gtgtgagccc cagagaagca     8280

gcggctatgg acccgcagca gagattactc ctcgaaacca gctgggagtt agtcgagaat     8340

gcagggattg atccacatag cctaaggggg accgccactg gtgtcttcct cggcgttgcc     8400

aagtttgggt atggcgagga tacggcagct gccgaagacg tcgaggggta ctctgtcact     8460

ggtgtagccc cggcagtggc gtcgggcaga attagttaca cgatggggtt ggaagggccg     8520

tctatttcgg ttgataccgc ctgttcctcc agtctggttg cactccacct tgcagtcgag     8580

tcgctccgga aaggagaaag cagtatggcc gtggtcgggg gagcggcggt gatggccaca     8640

ccgggtgtgt ttgtggattt ttcccgacag agagccttgg ccgcggatgg gcgttcaaag     8700

gcgttcggag caggtgcaga cgggtttgga tttagcgaag gtgtgacact ggttctccta     8760

gaaagattaa gtgaagcccg gcgtaacggc catgaggtgc tggcagttgt tagaggttcc     8820

gcattaaacc aggacggggc ttcgaacggg ctgagcgccc cctcgggccc ggcacagaga     8880

agagtgatac gccaagcact cgaatcgtgt ggcctagaac caggtgacgt tgacgcggtg     8940

gaagcgcacg ggacaggaac tgcgttaggg gacccgatag aagcaaacgc cttgctggac     9000

acttatggta gagatcgtga tgcggatcga cccctctggt taggaagtgt taagtcaaat     9060

ataggacaca ctcaggcagc ggcgggagta actgggctgc tcaaagtagt cctagcctta     9120

cgcaatgggg aactacccgc caccctacat gtcgaggaac cgacaccgca tgtggattgg     9180

tcgagcgggg gagttgctct cttggcgggt aatcagccgt ggcgaagagg tgaacgaacc     9240

cgtagagccg ccgtgtccgc attcgggatc agtggtacga acgcgcacgt gattgtggaa     9300

gaagctccac aagaggtgag accagcgccc ggtcaaggac tctcgcccgc ggtgtcaacc     9360

ttggtagtgg cgggtaaaac tatgcagcgt gtttcggcaa ccgccggtat gctcgcagat     9420

tggatggaag gcccaggtgc agatgtggcg ctggcggacg tggcgcacac gttaaatcat     9480

caccgttcac ggcaaccaaa gttcggtacg gtggtggcca gggaccggac acaggcaatc     9540

gccggactaa gagcgctggc ggcgggtcag cacgccccag gggttgttaa ccctgctgaa     9600

ggaagtccag gtccagggac ggtgttcgtg tttcctggcc aggggtccca gcgtgcaggc     9660

atgggggagg agttggctgc ggctttcccc gtgtttgcca gaatccacca gcaagtgtgg     9720

gatttactcg atgttcctga tctcgacgtt aacgaaacgg ggtacgcaca accagcactc     9780

ttcgcactcc aagtggcgct gtttgggctc ctcgaatcat ggggagtacg gccggatgcc     9840

gtggtcgggc atagtgtagg ggaattagcg gcagggtacg tttccgggct ttggagtctt     9900

gaggatgctt gcacgctcgt gtcggcgaga gcccgtctaa tgcaagcctt accggcaggt     9960

ggtgttatgg cggcagttcc agtgtccgaa gacgaagcac gggctgtgtt gggggaagga    10020

gtcgaaatag ctgcggtcaa cggtccgtcg agcgtggttc taagcggtga tgaagcagca    10080

gtgctccagg ccgcggaagg gttaggcaag tggacgcgat taccgacctc gcatgcattc    10140

cattctgctc gtatggaacc aatgctggaa gagtttagag cagtggcgga aggtctaaca    10200

tacaggactc cccaggtggc aatggccgcc ggagaccagg ttatgaccgc tgaatactgg    10260

gtgcgtcagg ttagggatac agttcgtttt ggcgagcaag ttgcctcgtt cgaggatgct    10320

gtattcgtgg aattgggagc agatcgctct cttgcacggc tagtcgatgg tatcgcgatg    10380

ttgcacgggg atcatgaggc acaggctggt atgcggagag aacaaccctt gcccttaggt    10440

ttacgaagat tgctaaccga cctgcataac gctggtgctg ccgtcgattt tagtgttttg    10500

tgcccacaag gtcgtctggt tgacgcaccg ttaccagcct ggtcacaccg gtttctcttc    10560

tatgaccggg aaggagtgga caatagatca ccagggggaa gcacagtggc ggtccacccg    10620

cttttactag ccgcggtgga tgtgccgggc cacggtggag cggttttcac gggtagactc    10680

tcgactgacg agcaaccgtg gttagcggag cacgttgtcg ggggaagaac cctagttcct    10740

ggttctgttt tagtcgatct agccttagcg gcaggcgaag acgtagggct accggtgtta    10800

gaagaattag tattgcagag gccgctggtg cttgccggcg cgggagcact cctacggatg    10860

tcggtcgggg caccagacga gagcggtaga agaactatcg atgttcacgc agctgaagac    10920

gtcgccgatt tagcagatgc ccaatggtcc cagcacgcca ccgggacttt agcccaaggg    10980

gtagcggcgg ggcccaggga cacagagcaa tggcccccag aggatgccgt ccggattcca    11040

ttagacgacc attatgatgg tctcgcggaa cagggttatg agtacggtcc gtcgtttcag    11100

gcgctagtgg cctacgtggc ggaggatgcg actgcgacaa tgttagcgga agtcgcgctt    11160

ccgggcagca ttagatcgca acaaggtcta tacgccatcc atcccgcact gctggacgct    11220

tgttttcaat ctgtcggagc ccacccagac agtcaatccg tcgggtcagg tctactcgta    11280

cccctcggtg ttcggagagt tcgtgcgtac gcacccgtaa ggaccgcccg ttattgttac    11340

acccgcgtca cgaaagttga actagctggg gttgaggccg acatcgacgt tctggatgct    11400

cacggcacag tgcttctagc cgtgtgcggt cttcgtatcg ggaccggagt gagcgagagg    11460

gacaaacaca acagagttct caatgagcgc ctactcacca tcgaatggca tcagcgtgaa    11520

ctaccagaaa tggacccctc gggtgccggg aagtggctcc taatctcgga ctgtgcagca    11580

tccgatgtca ccgctacacg actggctgat gccttccggg agcacagcgc tgcgtgcact    11640

accatgcggt ggccacttca cgatgatcaa ctagcagccg ccgaccaact ccgggaccag    11700

gtgggttcag atgagttttc tggcgtggta gtactaacag ggccaaacac agggacccct    11760

catcagggtt ccgcagaccg tggcgccgag tacgttaggc ggttagttgg aatcgctcgt    11820

gaacttagcg atcttcccgg agcggttccc cgtatgtatg tcgtcacaag gggagcgcag    11880

agagtccttg ccgatgattg tgttaattta gaacagggag ggctcagagg tctgctgagg    11940

accatcggtg ctgagcaccc acatctccgc gccacccaaa ttgatgttga tgagcagaca    12000

ggagtagagc agctggcgcg acaactccta gctacatcgg aggaagacga gacagcctgg    12060

agggacaacg aatggtacgt tgcgaggtta tgccccacac ccctgaggcc acaggaacgt    12120

aggacaatag tggcggacca tcaacagtct ggtatgcggt tacaaatacg tacgcccggt    12180

gcaatcgata gtgtggcctt tgaacccgca cccgatgtag agcaaccctt acgggcgggt    12240

gaagttcggg ttgacgttag agcaaccggt gttaatttcc gtgacgttct actcgctctc    12300

gggatgtatc cccagaaagc tgacatgggg acagaagcag ctggtgttgt aacagcagtg    12360

ggacctgatg tcgatgcgtt tgcgcctggt gatagagttc tagggctatt ccaaggggca    12420

tttgctccaa ttgcggtgac tgaccatcgt ttactggcac gggtgccaga cgggtggtca    12480

gatgccgatg cggcggcggt gccaatagct tacacgacag cacattatgc gctgcacgac    12540

ctggcggggt tgcgggcggg gcaatctgtc ctgatacacg cggcagcggg tggtgttggt    12600

atggccgctg ttgcactggc acggagggcc ggcgcagaag ttctggctac cgcaggacct    12660

gcaaaacacg gtacgctacg ggcattaggg ctagatgatg aacacatcgc ttcgagtcgg    12720

gagaccgggt tcgcgcgtaa gttccgagag cggactgggg gacgaggagt ggacgtcgtt    12780

ctaaacagct tgaccggcga actattagac gagtccgcgg atctcctcgc ggaggacgga    12840

gtcttcgtgg aaatgggaaa gactgatctg cgcgatgcag gggactttcg tgggcgctac    12900

gccccgtttg atctagggga agcaggcgat gacaggctcg gggaaattct acgtgaggtg    12960

gtgggactgc tcggtgcagg ggaactcgac cgactccctg ttagcgcgtg ggaattgggg    13020

ataccccaga cggggaagtc gttagtgacg ctgccacccg aacaagcgca agttttcaga    13080

ccagacggca ctgtattgat caccggggga acgggaacgt taggtcggct gctggcccgt    13140

catctggtta cagagcacgg ggtgcgtcac ctgctgctag tgtcgaggag aggagcagat    13200

gcccctggat cggacgagct gagggccgaa atcgaggatc tcggagcatc agcggaaatt    13260

gcagcatgtg atacagccga tcgagacgct ctcagcgcgt tgctagatgg actgccgagg    13320

ccactgaccg gagtagttca cgccgcggga gtcctcgctg acggtctggt tacatccatc    13380

gacgagcccg cagtcgaaca agttctccgt gcaaaagttg atgcggcctg gaacctgcac    13440

gagctaactg cgaacaccgg tctcagcttt ttcgtgctgt tctcgtcagc cgcaagtgtg    13500

ttagcggggc cggggcaggg agtatatgcg gcagcgaacg aatctttaaa cgctctggcc    13560

gctctgcgta ggactagggg tttacccgca aaagcattgg gatggggatt atgggcgata    13620

gggcgtgcaa tagcatttgc cgagcagacc ggtgacgcaa tcgccccgga ggaaggcgcg    13680

tacgccttcg agacactact cagacataac agggcgtact cgggttacgc tcccgtgata    13740

gggtcaccat ggctgactgc gttcgcccaa cattcgccct ttgcggagaa gttccagtcc    13800

ctggggcaaa atagatccgg gacgtctaag tttctggcag aattagtcga tctgccaaga    13860

gaagaatggc cagatcggtt acgtcgtcta ttagaactgg tgaggtctca tgctgccgca    13920

gtttcggggt atggatcggc agaccaatta ccagaaagaa aagcattcaa agacctcgga    13980

ttcgattcac tggcagcagt cgaactaaga aatcgtctag ggaccgcgac aggcgtccgg    14040

ctgcccagta ctctggtgtt cgaccaccca accccacttg cggttgcgga acatctacgt    14100

gatcgtctaa catccgggga agataaccct atccccctat gtcaaggcga tggggaggag    14160

atgagcacat ggctacgtcg ttttggaccc ccagtcgaac atcgggccag gctagtgtgt    14220

ttcccccacg caggcgcagc ggcggattca tacttagacc tagcaagagc gttagcacca    14280

gagatcgatg ttcatgctgt tcaatacccc ggcaggcaag acagaaggga cgaggagcca    14340

ttaggaaccg caggtgaaat tgcagatgaa gtggcagcgg tgctacgtgc gtcgggaggg    14400

gatgggcctt ttgcactttt cggccacagt atgggcgccc tcatcgcgta cgagacagca    14460

aggcgattag agagggaacc gggaggggga cccttacgtt tattcgtgag cggacaaaca    14520

gcgccacgtg tccatgaacg aagaactgat ctgcccggtg acgatggact cgtggacgag    14580

cttaggcgac ttggcacctc cgaggcagcg ctcgcagacg aagccctgct ggctatgtct    14640

ctcccggtgc tcagggcgga ttatagggtg ttaagatcct acgcttgggc ggatggtccc    14700

ccactacgcg ccggtataac tgccctctgc ggtgatgcag acccactaac tgcaacaggg    14760

gatgcggaac gctggttaca acattccgtg attccgggtc ggacacggac atttcccggt    14820

gggcattttt atttagggga acaagtgacc gaggtggcag gggctgtccg tagagattta    14880

ctgagagcag ggttagcggg ttga                                           14904


<210>  125
<211>  4967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-MalH

<400>  125

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Pro 
    2645                 2650                 2655             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2660                 2665                 2670             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2675                 2680                 2685             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2690                 2695                 2700             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2705                 2710                 2715             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2720                 2725                 2730             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2735                 2740                 2745             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2750                 2755                 2760             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2765                 2770                 2775             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2780                 2785                 2790             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2795                 2800                 2805             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2810                 2815                 2820             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2825                 2830                 2835             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2840                 2845                 2850             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2855                 2860                 2865             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2870                 2875                 2880             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2885                 2890                 2895             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2900                 2905                 2910             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2915                 2920                 2925             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2930                 2935                 2940             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2945                 2950                 2955             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2960                 2965                 2970             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2975                 2980                 2985             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2990                 2995                 3000             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    3005                 3010                 3015             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    3020                 3025                 3030             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    3035                 3040                 3045             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    3050                 3055                 3060             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    3065                 3070                 3075             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    3080                 3085                 3090             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    3095                 3100                 3105             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    3110                 3115                 3120             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    3125                 3130                 3135             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    3140                 3145                 3150             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    3155                 3160                 3165             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    3170                 3175                 3180             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    3185                 3190                 3195             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    3200                 3205                 3210             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    3215                 3220                 3225             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    3230                 3235                 3240             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    3245                 3250                 3255             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    3260                 3265                 3270             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    3275                 3280                 3285             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    3290                 3295                 3300             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    3305                 3310                 3315             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    3320                 3325                 3330             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    3335                 3340                 3345             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    3350                 3355                 3360             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    3365                 3370                 3375             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    3380                 3385                 3390             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    3395                 3400                 3405             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    3410                 3415                 3420             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    3425                 3430                 3435             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    3440                 3445                 3450             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    3455                 3460                 3465             


Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg 
    3470                 3475                 3480             


Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala Ala Val  Asp Phe Ser 
    3485                 3490                 3495             


Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala 
    3500                 3505                 3510             


Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn 
    3515                 3520                 3525             


Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val His Pro  Leu Leu Leu 
    3530                 3535                 3540             


Ala Ala  Val Asp Val Pro Gly  His Gly Gly Ala Val  Phe Thr Gly 
    3545                 3550                 3555             


Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu Ala Glu  His Val Val 
    3560                 3565                 3570             


Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val Leu Val  Asp Leu Ala 
    3575                 3580                 3585             


Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu 
    3590                 3595                 3600             


Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu 
    3605                 3610                 3615             


Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile 
    3620                 3625                 3630             


Asp Val  His Ala Ala Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln 
    3635                 3640                 3645             


Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala 
    3650                 3655                 3660             


Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg 
    3665                 3670                 3675             


Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr 
    3680                 3685                 3690             


Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu 
    3695                 3700                 3705             


Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser 
    3710                 3715                 3720             


Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu 
    3725                 3730                 3735             


Asp Ala  Cys Phe Gln Ser Val  Gly Ala His Pro Asp  Ser Gln Ser 
    3740                 3745                 3750             


Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly Val Arg  Arg Val Arg 
    3755                 3760                 3765             


Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val 
    3770                 3775                 3780             


Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu 
    3785                 3790                 3795             


Asp Ala  His Gly Thr Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile 
    3800                 3805                 3810             


Gly Thr  Gly Val Ser Glu Arg  Asp Lys His Asn Arg  Val Leu Asn 
    3815                 3820                 3825             


Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu 
    3830                 3835                 3840             


Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys 
    3845                 3850                 3855             


Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg 
    3860                 3865                 3870             


Glu His  Ser Ala Ala Cys Thr  Thr Met Arg Trp Pro  Leu His Asp 
    3875                 3880                 3885             


Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser 
    3890                 3895                 3900             


Asp Glu  Phe Ser Gly Val Val  Val Leu Thr Gly Pro  Asn Thr Gly 
    3905                 3910                 3915             


Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg 
    3920                 3925                 3930             


Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala 
    3935                 3940                 3945             


Val Pro  Arg Met Tyr Val Val  Thr Arg Gly Ala Gln  Arg Val Leu 
    3950                 3955                 3960             


Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu 
    3965                 3970                 3975             


Leu Arg  Thr Ile Gly Ala Glu  His Pro His Leu Arg  Ala Thr Gln 
    3980                 3985                 3990             


Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln 
    3995                 4000                 4005             


Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn 
    4010                 4015                 4020             


Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln 
    4025                 4030                 4035             


Glu Arg  Arg Thr Ile Val Ala  Asp His Gln Gln Ser  Gly Met Arg 
    4040                 4045                 4050             


Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu 
    4055                 4060                 4065             


Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg 
    4070                 4075                 4080             


Val Asp  Val Arg Ala Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu 
    4085                 4090                 4095             


Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala 
    4100                 4105                 4110             


Ala Gly  Val Val Thr Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala 
    4115                 4120                 4125             


Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro 
    4130                 4135                 4140             


Ile Ala  Val Thr Asp His Arg  Leu Leu Ala Arg Val  Pro Asp Gly 
    4145                 4150                 4155             


Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr 
    4160                 4165                 4170             


Ala His  Tyr Ala Leu His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln 
    4175                 4180                 4185             


Ser Val  Leu Ile His Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala 
    4190                 4195                 4200             


Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala 
    4205                 4210                 4215             


Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp 
    4220                 4225                 4230             


Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe 
    4235                 4240                 4245             


Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp Val Val  Leu Asn Ser 
    4250                 4255                 4260             


Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu 
    4265                 4270                 4275             


Asp Gly  Val Phe Val Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala 
    4280                 4285                 4290             


Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala 
    4295                 4300                 4305             


Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu 
    4310                 4315                 4320             


Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu 
    4325                 4330                 4335             


Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro 
    4340                 4345                 4350             


Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr 
    4355                 4360                 4365             


Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu Ala Arg  His Leu Val 
    4370                 4375                 4380             


Thr Glu  His Gly Val Arg His  Leu Leu Leu Val Ser  Arg Arg Gly 
    4385                 4390                 4395             


Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp 
    4400                 4405                 4410             


Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg 
    4415                 4420                 4425             


Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr 
    4430                 4435                 4440             


Gly Val  Val His Ala Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr 
    4445                 4450                 4455             


Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val Leu Arg  Ala Lys Val 
    4460                 4465                 4470             


Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu 
    4475                 4480                 4485             


Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly 
    4490                 4495                 4500             


Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala 
    4505                 4510                 4515             


Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu 
    4520                 4525                 4530             


Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu 
    4535                 4540                 4545             


Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe 
    4550                 4555                 4560             


Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro 
    4565                 4570                 4575             


Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro 
    4580                 4585                 4590             


Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr 
    4595                 4600                 4605             


Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp 
    4610                 4615                 4620             


Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu Val Arg  Ser His Ala 
    4625                 4630                 4635             


Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg 
    4640                 4645                 4650             


Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu 
    4655                 4660                 4665             


Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser 
    4670                 4675                 4680             


Thr Leu  Val Phe Asp His Pro  Thr Pro Leu Ala Val  Ala Glu His 
    4685                 4690                 4695             


Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    4700                 4705                 4710             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    4715                 4720                 4725             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    4730                 4735                 4740             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    4745                 4750                 4755             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    4760                 4765                 4770             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    4775                 4780                 4785             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    4790                 4795                 4800             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    4805                 4810                 4815             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    4820                 4825                 4830             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    4835                 4840                 4845             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    4850                 4855                 4860             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    4865                 4870                 4875             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    4880                 4885                 4890             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    4895                 4900                 4905             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    4910                 4915                 4920             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    4925                 4930                 4935             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    4940                 4945                 4950             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    4955                 4960                 4965         


<210>  126
<211>  13251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-MalOH

<400>  126
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct acctggaatt     7980

ggggcgctag ttcccgctcc cgtggtaatc gcagcaggcc gtacggagga accaattgcc     8040

atcgtttcga tggcatgtcg tttaccggga ggagtcaata cgccccaacg gctctgggaa     8100

ttactacggg agggtggtga aaccttgtcc gggttcccaa cggaccgtgg ctgggaccta     8160

gcacggcttc accaccctga tccggacaac cccggaacga gctacgttga taagggtgga     8220

tttctcgacg acgcggcggg tttcgacgca gagtttttcg gggtttcacc aagggaagct     8280

gccgctatgg accctcagca acgattactt ttagagacct cgtgggagct agttgaaaat     8340

gcgggcatag atccacatag cctgcgaggg acagcgacag gggtgttcct aggagttgcg     8400

aagtttggtt atggtgagga cacagcagca gcggaagatg ttgaaggtta ttcagttacc     8460

ggtgttgctc ccgctgtggc atctggccgc atatcctaca ctatgggttt agaaggtcct     8520

tccatctcgg tcgataccgc atgctcaagc tcgctagtcg cgcttcatct agccgtagag     8580

tccctccgaa agggtgagtc atctatggcg gtggtgggtg gtgcagccgt tatggcgact     8640

cctggggtat ttgttgattt ttcacgccaa cgggcgcttg ccgcagacgg ccgttccaaa     8700

gcgttcgggg caggtgcaga tggttttggt ttcagcgagg gagtcacgct ggttctacta     8760

gagcgtttaa gtgaggcgcg tcgtaacggt catgaagttc tagctgtagt gcgcgggtcc     8820

gcgttaaacc aggacggagc gagcaacgga ctttcagcac cctccggccc tgcgcaacgt     8880

agagtaataa ggcaagcgct cgaatcgtgt gggcttgaac cgggggatgt tgacgcggtt     8940

gaggcgcatg gtactggtac agcactaggt gacccaatag aggccaatgc gctgttggac     9000

acttacgggc gagaccgtga tgcggatcgt ccactttggt tggggtccgt taagagcaat     9060

attgggcaca ctcaagctgc ggccggggtt acaggactgc tgaaggttgt gttagcactg     9120

cgcaatggtg agctacctgc aacgttacat gtcgaggaac caactccaca cgtcgattgg     9180

tcctcaggtg gtgtcgcatt actggcgggt aatcaaccat ggcgaagggg agaaaggacc     9240

agaagggcgg cagtgagcgc ctttggtatc tccggtacaa atgctcacgt gatagtggaa     9300

gaggcgcctc aggaagttcg acccgcccct ggccaagggc tgtcgccagc cgtgtccacg     9360

ttagttgttg caggtaaaac catgcagcgt gtaagtgcga cagctggaat gcttgcagac     9420

tggatggagg gtcctggggc cgatgttgca ttggcggatg tggcccatac cctgaaccat     9480

caccgatcaa gacagcccaa gttcgggacg gttgtagcgc gtgacaggac tcaggcgata     9540

gctgggctcc gtgcattggc ggctggtcaa catgctcctg gggtcgtcaa cccagctgaa     9600

ggttccccag gaccaggcac cgtgttcgtt tttcccggtc aaggttcgca gagggcaggg     9660

atgggggagg aactcgcggc agcctttcct gtcttcgctc gaatacatca gcaagtttgg     9720

gacctcctag atgttcccga cctcgacgtt aatgaaaccg ggtacgccca accagcgctg     9780

ttcgcgcttc aggtcgcgct ctttggcctt ctggagtcgt ggggtgttag gccagatgca     9840

gtggtagggc actcagttgg tgagctggcc gcggggtacg tgtccggtct ttggtcacta     9900

gaggacgcct gcacactagt ctcagcaaga gcgcgcctaa tgcaggcact gcctgctgga     9960

ggggtgatgg cggcagtccc cgtctccgag gatgaggcgc gggccgtcct gggcgaggga    10020

gttgaaattg cggctgtgaa tggaccctcg tccgttgtgc tctcagggga cgaggcggca    10080

gtcttacagg ccgccgaagg tctaggtaag tggacgcgac tgccgaccag ccatgctttt    10140

cactcagcga gaatggaacc catgctagaa gagtttcggg ccgtagcaga gggtctgacc    10200

tatcgtaccc ctcaagtagc tatggctgct ggggatcagg tgatgacagc agaatattgg    10260

gtgcggcagg ttcgggacac agttcgcttc ggggagcaag tagcgtcatt cgaggatgcg    10320

gtgtttgttg agttaggcgc tgacagaagt ctagcgcgtt tggtggacgg catcgccatg    10380

ctgcacggtg accacgaagc gcaggccgcg gaccataggc aaatcaccga agcggttgcg    10440

gatgcttacg tcttaggcca ccttccggat tttgcggcgc tgcggcggcc tcacgcacga    10500

aagttggact taccaactta tcccttcgag cgtagacagt actggttcag agatgcgcgt    10560

gagaggccgg aacaacccag agataccggc ggacctcgca cagaagcagt ccgtctgtta    10620

gaggatggta ggattgaaga attagctgca cttttgggag gggccagtga tgaccaacac    10680

acattacagg tgctgactaa gttggcggcg caacataacc aacaacgaac aacccggtca    10740

atcgctgacg acaggtacga aataaggtgg gaccgatcga cttccccact atccggagca    10800

gatgttgacc aagcggggag ctggatcgtg gtgtcagatg acgcagatgc cgttcccccg    10860

ctagtggact tgctggctgc acgtaacgag ccccatcagg ttgttggtct acccgcttcg    10920

gacgcagacg aggagaggct cgcagagact ctgcgtgcgg ctgcgactga agatgctacc    10980

cttcggatag tccacgttgc ggcgctcgaa gcaggcgcta cccccagcat gcgttcactg    11040

ctccgcatgc agcaccgaat actaggtggc acgcggcggg tgttcagggc agcggtcgca    11100

gcggagttaa gaggtcccat ttggatagtg acgcggggag cacaaagagt ggctgacacc    11160

gatacagttg ccccgcatca gtcatgcctc tggggatttg ggagggcagc atcgctggag    11220

ctgccgcacg tttggggtgg cctagcagat ttatcagagg gcggtgacaa tgcggccgat    11280

gagtggagtg cgctagtgga ccgcattgcc gcaccccacg gttcagcagt tagggaggac    11340

caactggcgc tgagagacag ggccgtatat acgccaagac tggccagacg ttctgcgccc    11400

ccgagcggga ctcccctaca tctacgaggg gatggcacag tgttaataac aggtgggact    11460

ggtacactag gtaggctatt agcgcgtcac ctagtaacag agcatggggt gcggcatctc    11520

ttactagttt caaggagagg cgccgatgcc cctggctcgg atgaactgcg cgcagaaata    11580

gaggacttag gtgccagcgc ggagatcgca gcgtgtgata cagcggatcg cgatgcccta    11640

tctgccctac tagatggtct cccccggccc cttacgggtg tcgttcacgc cgctggcgtg    11700

ttagccgatg gacttgtcac tagcattgac gagcctgcgg tggaacaggt tctccgagca    11760

aaggtggacg cggcatggaa cctacacgaa ctcacagcta ataccgggct atcctttttc    11820

gttcttttct catcagcagc atcggtcctg gcaggtccag ggcaaggagt ttatgcggct    11880

gcaaatgaat cgctcaacgc actagctgcg ttaaggcgaa ctaggggtct gccggccaag    11940

gctctgggat ggggcctgtg ggccatcggg cgggcaatcg cttttgcgga gcagaccggg    12000

gacgccatcg ctccagagga aggagcatac gcttttgaaa ctctgttaag gcataaccgt    12060

gcctactcgg gatatgcgcc cgtcattgga tctccctggt tgaccgcgtt cgcacagcat    12120

tccccctttg cagaaaaatt ccaatcactc ggacagaatc ggtcagggac atcgaaattc    12180

ttagcggagc tagttgacct gcctcgtgag gaatggccgg ataggctcag gagactacta    12240

gagttagtta ggtcccatgc cgccgcggtc tccggttacg gtagtgcaga tcaactgccg    12300

gaaagaaaag cgttcaagga tttggggttt gattcgctgg ccgccgttga actgcgtaac    12360

cggctgggaa cggctacagg ggtacgactg ccgtcaaccc tagtatttga tcacccaact    12420

ccgctggccg tcgctgagca cttaagagat aggctaacat ccggggaaga taaccctatc    12480

cccctatgtc aaggcgatgg ggaggagatg agcacatggc tacgtcgttt tggaccccca    12540

gtcgaacatc gggccaggct agtgtgtttc ccccacgcag gcgcagcggc ggattcatac    12600

ttagacctag caagagcgtt agcaccagag atcgatgttc atgctgttca ataccccggc    12660

aggcaagaca gaagggacga ggagccatta ggaaccgcag gtgaaattgc agatgaagtg    12720

gcagcggtgc tacgtgcgtc gggaggggat gggccttttg cacttttcgg ccacagtatg    12780

ggcgccctca tcgcgtacga gacagcaagg cgattagaga gggaaccggg agggggaccc    12840

ttacgtttat tcgtgagcgg acaaacagcg ccacgtgtcc atgaacgaag aactgatctg    12900

cccggtgacg atggactcgt ggacgagctt aggcgacttg gcacctccga ggcagcgctc    12960

gcagacgaag ccctgctggc tatgtctctc ccggtgctca gggcggatta tagggtgtta    13020

agatcctacg cttgggcgga tggtccccca ctacgcgccg gtataactgc cctctgcggt    13080

gatgcagacc cactaactgc aacaggggat gcggaacgct ggttacaaca ttccgtgatt    13140

ccgggtcgga cacggacatt tcccggtggg catttttatt taggggaaca agtgaccgag    13200

gtggcagggg ctgtccgtag agatttactg agagcagggt tagcgggttg a             13251


<210>  127
<211>  4416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-MalOH

<400>  127

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Pro 
    2645                 2650                 2655             


Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val Val Ile  Ala Ala Gly 
    2660                 2665                 2670             


Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser Met Ala  Cys Arg Leu 
    2675                 2680                 2685             


Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu Trp Glu  Leu Leu Arg 
    2690                 2695                 2700             


Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro Thr Asp  Arg Gly Trp 
    2705                 2710                 2715             


Asp Leu  Ala Arg Leu His His  Pro Asp Pro Asp Asn  Pro Gly Thr 
    2720                 2725                 2730             


Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp Asp Ala  Ala Gly Phe 
    2735                 2740                 2745             


Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg Glu Ala  Ala Ala Met 
    2750                 2755                 2760             


Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr Ser Trp  Glu Leu Val 
    2765                 2770                 2775             


Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu Arg Gly  Thr Ala Thr 
    2780                 2785                 2790             


Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly Tyr Gly  Glu Asp Thr 
    2795                 2800                 2805             


Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser Val Thr  Gly Val Ala 
    2810                 2815                 2820             


Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr Thr Met  Gly Leu Glu 
    2825                 2830                 2835             


Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys Ser Ser  Ser Leu Val 
    2840                 2845                 2850             


Ala Leu  His Leu Ala Val Glu  Ser Leu Arg Lys Gly  Glu Ser Ser 
    2855                 2860                 2865             


Met Ala  Val Val Gly Gly Ala  Ala Val Met Ala Thr  Pro Gly Val 
    2870                 2875                 2880             


Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu Ala Ala  Asp Gly Arg 
    2885                 2890                 2895             


Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly Phe Gly  Phe Ser Glu 
    2900                 2905                 2910             


Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu Ser Glu  Ala Arg Arg 
    2915                 2920                 2925             


Asn Gly  His Glu Val Leu Ala  Val Val Arg Gly Ser  Ala Leu Asn 
    2930                 2935                 2940             


Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala Pro Ser  Gly Pro Ala 
    2945                 2950                 2955             


Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu Ser Cys  Gly Leu Glu 
    2960                 2965                 2970             


Pro Gly  Asp Val Asp Ala Val  Glu Ala His Gly Thr  Gly Thr Ala 
    2975                 2980                 2985             


Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu Leu Asp  Thr Tyr Gly 
    2990                 2995                 3000             


Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp Leu Gly  Ser Val Lys 
    3005                 3010                 3015             


Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala Gly Val  Thr Gly Leu 
    3020                 3025                 3030             


Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly Glu Leu  Pro Ala Thr 
    3035                 3040                 3045             


Leu His  Val Glu Glu Pro Thr  Pro His Val Asp Trp  Ser Ser Gly 
    3050                 3055                 3060             


Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro Trp Arg  Arg Gly Glu 
    3065                 3070                 3075             


Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe Gly Ile  Ser Gly Thr 
    3080                 3085                 3090             


Asn Ala  His Val Ile Val Glu  Glu Ala Pro Gln Glu  Val Arg Pro 
    3095                 3100                 3105             


Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val Ser Thr  Leu Val Val 
    3110                 3115                 3120             


Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala Thr Ala  Gly Met Leu 
    3125                 3130                 3135             


Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp Val Ala  Leu Ala Asp 
    3140                 3145                 3150             


Val Ala  His Thr Leu Asn His  His Arg Ser Arg Gln  Pro Lys Phe 
    3155                 3160                 3165             


Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu 
    3170                 3175                 3180             


Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro Gly Val  Val Asn Pro 
    3185                 3190                 3195             


Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly 
    3200                 3205                 3210             


Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala 
    3215                 3220                 3225             


Phe Pro  Val Phe Ala Arg Ile  His Gln Gln Val Trp  Asp Leu Leu 
    3230                 3235                 3240             


Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro 
    3245                 3250                 3255             


Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser 
    3260                 3265                 3270             


Trp Gly  Val Arg Pro Asp Ala  Val Val Gly His Ser  Val Gly Glu 
    3275                 3280                 3285             


Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala 
    3290                 3295                 3300             


Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro 
    3305                 3310                 3315             


Ala Gly  Gly Val Met Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala 
    3320                 3325                 3330             


Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly 
    3335                 3340                 3345             


Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln 
    3350                 3355                 3360             


Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His 
    3365                 3370                 3375             


Ala Phe  His Ser Ala Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg 
    3380                 3385                 3390             


Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met 
    3395                 3400                 3405             


Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln 
    3410                 3415                 3420             


Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu 
    3425                 3430                 3435             


Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg 
    3440                 3445                 3450             


Leu Val  Asp Gly Ile Ala Met  Leu His Gly Asp His  Glu Ala Gln 
    3455                 3460                 3465             


Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr 
    3470                 3475                 3480             


Val Leu  Gly His Leu Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His 
    3485                 3490                 3495             


Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln 
    3500                 3505                 3510             


Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp 
    3515                 3520                 3525             


Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly 
    3530                 3535                 3540             


Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp 
    3545                 3550                 3555             


Gln His  Thr Leu Gln Val Leu  Thr Lys Leu Ala Ala  Gln His Asn 
    3560                 3565                 3570             


Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile 
    3575                 3580                 3585             


Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp 
    3590                 3595                 3600             


Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp Asp Ala  Asp Ala Val 
    3605                 3610                 3615             


Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln 
    3620                 3625                 3630             


Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala 
    3635                 3640                 3645             


Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile 
    3650                 3655                 3660             


Val His  Val Ala Ala Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg 
    3665                 3670                 3675             


Ser Leu  Leu Arg Met Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg 
    3680                 3685                 3690             


Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp 
    3695                 3700                 3705             


Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val 
    3710                 3715                 3720             


Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser 
    3725                 3730                 3735             


Leu Glu  Leu Pro His Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu 
    3740                 3745                 3750             


Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg 
    3755                 3760                 3765             


Ile Ala  Ala Pro His Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala 
    3770                 3775                 3780             


Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser 
    3785                 3790                 3795             


Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr 
    3800                 3805                 3810             


Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala 
    3815                 3820                 3825             


Arg His  Leu Val Thr Glu His  Gly Val Arg His Leu  Leu Leu Val 
    3830                 3835                 3840             


Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala 
    3845                 3850                 3855             


Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp 
    3860                 3865                 3870             


Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro 
    3875                 3880                 3885             


Arg Pro  Leu Thr Gly Val Val  His Ala Ala Gly Val  Leu Ala Asp 
    3890                 3895                 3900             


Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu 
    3905                 3910                 3915             


Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala 
    3920                 3925                 3930             


Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser 
    3935                 3940                 3945             


Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu 
    3950                 3955                 3960             


Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro 
    3965                 3970                 3975             


Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile 
    3980                 3985                 3990             


Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly 
    3995                 4000                 4005             


Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser 
    4010                 4015                 4020             


Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala 
    4025                 4030                 4035             


Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn 
    4040                 4045                 4050             


Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro 
    4055                 4060                 4065             


Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val 
    4070                 4075                 4080             


Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln 
    4085                 4090                 4095             


Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu 
    4100                 4105                 4110             


Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val 
    4115                 4120                 4125             


Arg Leu  Pro Ser Thr Leu Val  Phe Asp His Pro Thr  Pro Leu Ala 
    4130                 4135                 4140             


Val Ala  Glu His Leu Arg Asp  Arg Leu Thr Ser Gly  Glu Asp Asn 
    4145                 4150                 4155             


Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp 
    4160                 4165                 4170             


Leu Arg  Arg Phe Gly Pro Pro  Val Glu His Arg Ala  Arg Leu Val 
    4175                 4180                 4185             


Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu 
    4190                 4195                 4200             


Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val His Ala  Val Gln Tyr 
    4205                 4210                 4215             


Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala 
    4220                 4225                 4230             


Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly 
    4235                 4240                 4245             


Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His Ser Met  Gly Ala Leu 
    4250                 4255                 4260             


Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly 
    4265                 4270                 4275             


Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val 
    4280                 4285                 4290             


His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp 
    4295                 4300                 4305             


Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu 
    4310                 4315                 4320             


Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg 
    4325                 4330                 4335             


Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala 
    4340                 4345                 4350             


Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr 
    4355                 4360                 4365             


Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser Val Ile  Pro Gly Arg 
    4370                 4375                 4380             


Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val 
    4385                 4390                 4395             


Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly 
    4400                 4405                 4410             


Leu Ala  Gly 
    4415     


<210>  128
<211>  10044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-Ser

<400>  128
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atcgtttcga tggcatgtcg tttaccggga     1620

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     1680

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     1740

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     1800

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     1860

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     1920

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     1980

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     2040

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     2100

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     2160

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     2220

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     2280

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     2340

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     2400

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     2460

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     2520

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     2580

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     2640

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     2700

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     2760

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     2820

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     2880

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     2940

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     3000

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     3060

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     3120

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     3180

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     3240

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     3300

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     3360

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     3420

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     3480

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     3540

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     3600

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     3660

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     3720

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     3780

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     3840

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     3900

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     3960

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     4020

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     4080

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     4140

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     4200

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     4260

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     4320

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     4380

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     4440

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     4500

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     4560

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     4620

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     4680

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     4740

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     4800

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     4860

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     4920

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     4980

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     5040

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     5100

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     5160

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     5220

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     5280

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     5340

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     5400

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     5460

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     5520

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     5580

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     5640

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     5700

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     5760

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     5820

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     5880

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     5940

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     6000

aggctattgg cttccgctcg tgctccgcgt gacgtccgcc aaacagctca cgctgacgct     6060

gctgaaccgg ctggcgacga cggccttcag cacttgccct tagtagctgc gcaacctgga     6120

atatggatgg ccgagaagtt atctgaacta ccatcagcgt ggagcgtagc gcattacgtg     6180

gagctcactg gtgaggttga ctcgcctctt ttggccaggg cggtagtggc tggccttgca     6240

caagctgaca ccttaagaat gcgtttcaca gaggataatg gggaagtttg gcaatgggta     6300

gacgatgcgt taacatttga gttaccggaa atcatagacc tgcgcactaa catagaccct     6360

cacgggacag ctcaggcctt gatgcaagcg gacctgcaac aggacctacg tgtggattcg     6420

gggaagcctc tggtcttcca tcagctaatt caagtagcgg acaatcgctg gtactggtat     6480

caaaggtacc accacttgct tgtggacggg ttcagttttc cagcgataac caggcaaata     6540

gccaacattt attgcacttg gttgcgagga gagcctacgc ccgcatcccc cttcacgcca     6600

ttcgcagacg ttgttgagga ataccaacag tatcgcgaga gcgaagcgtg gcaacgcgat     6660

gcggcattct gggcggagca acgacggcaa ctaccgcctc ccgcatccct atcacctgcc     6720

ccgctccccg gccggtccgc gtcagccgac attctacggc taaagctgga gttcacagat     6780

ggtgaatttc gacagcttgc tacacaactc agcggggtac aaaggacaga cctagcgctc     6840

gctctggctg cattatggct aggacgactt tgcaatcgaa tggactacgc ggcgggtttc     6900

atatttatgc gccggctcgg cagcgcagcg ttgaccgcaa cgggtccagt tttaaatgtt     6960

cttcctttgg gaatccacat aggcaaccca agcttctctg agcttctcac cagggttcgc     7020

gaggtcgcct taggcgcgta tgcacaccaa catattcctt ttgagatgtt agtagaggca     7080

ctgcaaccag agcgaaacct tagccatact cctctcttcc aagtgatgtt tgtccttcag     7140

aatgcgcccg cgtcccaatt agagttaacc gggatcaccg caaacccaat taaggttaaa     7200

tcaactacca cgaagttcga cctaacttta atcatgcaaa acacagctag cggattagta     7260

ggtgtttggg agtacaacac ggatttattc gacgcgtcaa cgattgagcg aatgacaggg     7320

cactttgtaa ccctcctcga gggcgttatc gccaatccac aacagccgat ctctcaactt     7380

cctattttaa ctacagtgga gcaacagcaa cttttagtcg agtggaataa cacgcaaacc     7440

gactaccccg ctgataagtg tatacatcaa ttattcgagg aacaggtcga gcgcacacca     7500

gacgccgttg ctgtcgtctt tgggaatcag caactcagct atcgagagat gcgcgaacaa     7560

gtggttgcac tcgccaattt attacgtgag cggggagtca agccaggaga ctccgttgcc     7620

gtggccttac cacgctctgt tttcttaacc cttgcactac acgcgattgt cgaggcaggt     7680

gccgcctggc tacctcttga cacaggatat cctgacgata gattaaaaat gatgctcgag     7740

gatgcacggc cttcccttct gatcacaaca gacgatcaat taccccgctt cagtgacgta     7800

cctaatctga cctcactctg ttacaacgct cccttgacgc ctcaagggag cgccccttta     7860

cagctgtctc aacctcacca tactgcatat atcatcttta caagtggttc tacgggacgc     7920

cccaagggag taatggttgg tcagactgcg attgtaaatc gtctgttgtg gatgcaaaac     7980

cactaccctt tgacggggga ggacgttgta gcccaaaaga ctccttgctc gttcgatgtc     8040

tcagtctggg agttcttttg gccatttata gcaggggcca aattagttat ggcggagccg     8100

gaagcccacc gagacccact tgcgatgcag caattctttg ctgagtatgg tgtcaccact     8160

acacatttcg tcccatcgat gttagcggcc ttcgtggctt ctcttactcc acaaacggct     8220

aggcaatctt gtgccacact aaagcaagtc ttctgctccg gcgaggcatt acctgcagac     8280

ttgtgccggg aatggcagca actcacagga gctccattgc acaatctata cggaccgacc     8340

gaggccgcag tagacgtatc ttggtatcct gcgtttggcg aggagttagc gcaagtaaga     8400

ggttcgtcag taccaatagg ataccccgta tggaacacgg ggcttcggat actggacgcg     8460

atgatgcatc cggtcccacc aggagtcgcg ggcgatttat acctgactgg gatacagctg     8520

gcccaaggtt acctagggag acctgacctt acggcgtcga ggttcatagc ggatccgttt     8580

gctccgggtg agcgcatgta ccgtacgggc gacgtcgcgc gatggctaga taatggcgcc     8640

gtagagtatc ttggtagatc agacgatcag ttaaagatac ggggacaacg aatagagctt     8700

ggggaaatag accgggtaat gcaggctttg ccagatgtcg agcaagcggt ggcttcgtgt     8760

gctattgcgc gggaggacat acctgggaac aaacaccttg tagcgtacat agttcctcaa     8820

gaggagcaaa catgcactga gcgatcgagg tccacactta cagtttcgtt cgtccggagt     8880

ttccttaagg agaaactccc cgaatatatg gtaccgagcg caatagtgat tctagacgct     8940

ctccccctga ctcctaatgg aaagctagac cggcgggcgt tacccgcccc tgacctgcac     9000

tcacaacttg agacaattat tgctgcggct ttctcgagcc tgctcgggtg cgacgtacaa     9060

gacgcggatg ctgacttttt cgcgctaggt ggccattcgc tgcttgccat gaagctagcc     9120

gctcagcttt cccgacaagt agcgcggcag gtgacaccag gccaagttat ggtagcttcg     9180

actgtcgcaa agctcgcaac gatcatagac gcggagttag ataaatacgt cgctccaagg     9240

aacccgataa catccgggga agataaccct atccccctat gtcaaggcga tggggaggag     9300

atgagcacat ggctacgtcg ttttggaccc ccagtcgaac atcgggccag gctagtgtgt     9360

ttcccccacg caggcgcagc ggcggattca tacttagacc tagcaagagc gttagcacca     9420

gagatcgatg ttcatgctgt tcaatacccc ggcaggcaag acagaaggga cgaggagcca     9480

ttaggaaccg caggtgaaat tgcagatgaa gtggcagcgg tgctacgtgc gtcgggaggg     9540

gatgggcctt ttgcactttt cggccacagt atgggcgccc tcatcgcgta cgagacagca     9600

aggcgattag agagggaacc gggaggggga cccttacgtt tattcgtgag cggacaaaca     9660

gcgccacgtg tccatgaacg aagaactgat ctgcccggtg acgatggact cgtggacgag     9720

cttaggcgac ttggcacctc cgaggcagcg ctcgcagacg aagccctgct ggctatgtct     9780

ctcccggtgc tcagggcgga ttatagggtg ttaagatcct acgcttgggc ggatggtccc     9840

ccactacgcg ccggtataac tgccctctgc ggtgatgcag acccactaac tgcaacaggg     9900

gatgcggaac gctggttaca acattccgtg attccgggtc ggacacggac atttcccggt     9960

gggcattttt atttagggga acaagtgacc gaggtggcag gggctgtccg tagagattta    10020

ctgagagcag ggttagcggg ttga                                           10044


<210>  129
<211>  3347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalOH-Ser

<400>  129

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Ala  Asp His Arg 
    1310                 1315                 1320             


Gln Ile  Thr Glu Ala Val Ala  Asp Ala Tyr Val Leu  Gly His Leu 
    1325                 1330                 1335             


Pro Asp  Phe Ala Ala Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp 
    1340                 1345                 1350             


Leu Pro  Thr Tyr Pro Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp 
    1355                 1360                 1365             


Ala Arg  Glu Arg Pro Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg 
    1370                 1375                 1380             


Thr Glu  Ala Val Arg Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu 
    1385                 1390                 1395             


Ala Ala  Leu Leu Gly Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln 
    1400                 1405                 1410             


Val Leu  Thr Lys Leu Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr 
    1415                 1420                 1425             


Arg Ser  Ile Ala Asp Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser 
    1430                 1435                 1440             


Thr Ser  Pro Leu Ser Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp 
    1445                 1450                 1455             


Ile Val  Val Ser Asp Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp 
    1460                 1465                 1470             


Leu Leu  Ala Ala Arg Asn Glu  Pro His Gln Val Val  Gly Leu Pro 
    1475                 1480                 1485             


Ala Ser  Asp Ala Asp Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala 
    1490                 1495                 1500             


Ala Ala  Thr Glu Asp Ala Thr  Leu Arg Ile Val His  Val Ala Ala 
    1505                 1510                 1515             


Leu Glu  Ala Gly Ala Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met 
    1520                 1525                 1530             


Gln His  Arg Ile Leu Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala 
    1535                 1540                 1545             


Val Ala  Ala Glu Leu Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly 
    1550                 1555                 1560             


Ala Gln  Arg Val Ala Asp Thr  Asp Thr Val Ala Pro  His Gln Ser 
    1565                 1570                 1575             


Cys Leu  Trp Gly Phe Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His 
    1580                 1585                 1590             


Val Trp  Gly Gly Leu Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala 
    1595                 1600                 1605             


Ala Asp  Glu Trp Ser Ala Leu  Val Asp Arg Ile Ala  Ala Pro His 
    1610                 1615                 1620             


Gly Ser  Ala Val Arg Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala 
    1625                 1630                 1635             


Val Tyr  Thr Pro Arg Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly 
    1640                 1645                 1650             


Thr Pro  Leu His Leu Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly 
    1655                 1660                 1665             


Gly Thr  Gly Thr Leu Gly Arg  Leu Leu Ala Arg His  Leu Val Thr 
    1670                 1675                 1680             


Glu His  Gly Val Arg His Leu  Leu Leu Val Ser Arg  Arg Gly Ala 
    1685                 1690                 1695             


Asp Ala  Pro Gly Ser Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu 
    1700                 1705                 1710             


Gly Ala  Ser Ala Glu Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp 
    1715                 1720                 1725             


Ala Leu  Ser Ala Leu Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly 
    1730                 1735                 1740             


Val Val  His Ala Ala Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser 
    1745                 1750                 1755             


Ile Asp  Glu Pro Ala Val Glu  Gln Val Leu Arg Ala  Lys Val Asp 
    1760                 1765                 1770             


Ala Ala  Trp Asn Leu His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser 
    1775                 1780                 1785             


Phe Phe  Val Leu Phe Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro 
    1790                 1795                 1800             


Gly Gln  Gly Val Tyr Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu 
    1805                 1810                 1815             


Ala Ala  Leu Arg Arg Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly 
    1820                 1825                 1830             


Trp Gly  Leu Trp Ala Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln 
    1835                 1840                 1845             


Thr Gly  Asp Ala Ile Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu 
    1850                 1855                 1860             


Thr Leu  Leu Arg His Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val 
    1865                 1870                 1875             


Ile Gly  Ser Pro Trp Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe 
    1880                 1885                 1890             


Ala Glu  Lys Phe Gln Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser 
    1895                 1900                 1905             


Lys Phe  Leu Ala Glu Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro 
    1910                 1915                 1920             


Asp Arg  Leu Arg Arg Leu Leu  Glu Leu Val Arg Ser  His Ala Ala 
    1925                 1930                 1935             


Ala Val  Ser Gly Tyr Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys 
    1940                 1945                 1950             


Ala Phe  Lys Asp Leu Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu 
    1955                 1960                 1965             


Arg Asn  Arg Leu Gly Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr 
    1970                 1975                 1980             


Leu Val  Phe Asp His Pro Thr  Pro Leu Ala Val Ala  Glu His Leu 
    1985                 1990                 1995             


Arg Asp  Arg Leu Leu Ala Ser  Ala Arg Ala Pro Arg  Asp Val Arg 
    2000                 2005                 2010             


Gln Thr  Ala His Ala Asp Ala  Ala Glu Pro Ala Gly  Asp Asp Gly 
    2015                 2020                 2025             


Leu Gln  His Leu Pro Leu Val  Ala Ala Gln Pro Gly  Ile Trp Met 
    2030                 2035                 2040             


Ala Glu  Lys Leu Ser Glu Leu  Pro Ser Ala Trp Ser  Val Ala His 
    2045                 2050                 2055             


Tyr Val  Glu Leu Thr Gly Glu  Val Asp Ser Pro Leu  Leu Ala Arg 
    2060                 2065                 2070             


Ala Val  Val Ala Gly Leu Ala  Gln Ala Asp Thr Leu  Arg Met Arg 
    2075                 2080                 2085             


Phe Thr  Glu Asp Asn Gly Glu  Val Trp Gln Trp Val  Asp Asp Ala 
    2090                 2095                 2100             


Leu Thr  Phe Glu Leu Pro Glu  Ile Ile Asp Leu Arg  Thr Asn Ile 
    2105                 2110                 2115             


Asp Pro  His Gly Thr Ala Gln  Ala Leu Met Gln Ala  Asp Leu Gln 
    2120                 2125                 2130             


Gln Asp  Leu Arg Val Asp Ser  Gly Lys Pro Leu Val  Phe His Gln 
    2135                 2140                 2145             


Leu Ile  Gln Val Ala Asp Asn  Arg Trp Tyr Trp Tyr  Gln Arg Tyr 
    2150                 2155                 2160             


His His  Leu Leu Val Asp Gly  Phe Ser Phe Pro Ala  Ile Thr Arg 
    2165                 2170                 2175             


Gln Ile  Ala Asn Ile Tyr Cys  Thr Trp Leu Arg Gly  Glu Pro Thr 
    2180                 2185                 2190             


Pro Ala  Ser Pro Phe Thr Pro  Phe Ala Asp Val Val  Glu Glu Tyr 
    2195                 2200                 2205             


Gln Gln  Tyr Arg Glu Ser Glu  Ala Trp Gln Arg Asp  Ala Ala Phe 
    2210                 2215                 2220             


Trp Ala  Glu Gln Arg Arg Gln  Leu Pro Pro Pro Ala  Ser Leu Ser 
    2225                 2230                 2235             


Pro Ala  Pro Leu Pro Gly Arg  Ser Ala Ser Ala Asp  Ile Leu Arg 
    2240                 2245                 2250             


Leu Lys  Leu Glu Phe Thr Asp  Gly Glu Phe Arg Gln  Leu Ala Thr 
    2255                 2260                 2265             


Gln Leu  Ser Gly Val Gln Arg  Thr Asp Leu Ala Leu  Ala Leu Ala 
    2270                 2275                 2280             


Ala Leu  Trp Leu Gly Arg Leu  Cys Asn Arg Met Asp  Tyr Ala Ala 
    2285                 2290                 2295             


Gly Phe  Ile Phe Met Arg Arg  Leu Gly Ser Ala Ala  Leu Thr Ala 
    2300                 2305                 2310             


Thr Gly  Pro Val Leu Asn Val  Leu Pro Leu Gly Ile  His Ile Gly 
    2315                 2320                 2325             


Asn Pro  Ser Phe Ser Glu Leu  Leu Thr Arg Val Arg  Glu Val Ala 
    2330                 2335                 2340             


Leu Gly  Ala Tyr Ala His Gln  His Ile Pro Phe Glu  Met Leu Val 
    2345                 2350                 2355             


Glu Ala  Leu Gln Pro Glu Arg  Asn Leu Ser His Thr  Pro Leu Phe 
    2360                 2365                 2370             


Gln Val  Met Phe Val Leu Gln  Asn Ala Pro Ala Ser  Gln Leu Glu 
    2375                 2380                 2385             


Leu Thr  Gly Ile Thr Ala Asn  Pro Ile Lys Val Lys  Ser Thr Thr 
    2390                 2395                 2400             


Thr Lys  Phe Asp Leu Thr Leu  Ile Met Gln Asn Thr  Ala Ser Gly 
    2405                 2410                 2415             


Leu Val  Gly Val Trp Glu Tyr  Asn Thr Asp Leu Phe  Asp Ala Ser 
    2420                 2425                 2430             


Thr Ile  Glu Arg Met Thr Gly  His Phe Val Thr Leu  Leu Glu Gly 
    2435                 2440                 2445             


Val Ile  Ala Asn Pro Gln Gln  Pro Ile Ser Gln Leu  Pro Ile Leu 
    2450                 2455                 2460             


Thr Thr  Val Glu Gln Gln Gln  Leu Leu Val Glu Trp  Asn Asn Thr 
    2465                 2470                 2475             


Gln Thr  Asp Tyr Pro Ala Asp  Lys Cys Ile His Gln  Leu Phe Glu 
    2480                 2485                 2490             


Glu Gln  Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
    2495                 2500                 2505             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    2510                 2515                 2520             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    2525                 2530                 2535             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    2540                 2545                 2550             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    2555                 2560                 2565             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    2570                 2575                 2580             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    2585                 2590                 2595             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    2600                 2605                 2610             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    2615                 2620                 2625             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    2630                 2635                 2640             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    2645                 2650                 2655             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    2660                 2665                 2670             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    2675                 2680                 2685             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    2690                 2695                 2700             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    2705                 2710                 2715             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    2720                 2725                 2730             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    2735                 2740                 2745             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    2750                 2755                 2760             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    2765                 2770                 2775             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    2780                 2785                 2790             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    2795                 2800                 2805             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    2810                 2815                 2820             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    2825                 2830                 2835             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    2840                 2845                 2850             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    2855                 2860                 2865             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    2870                 2875                 2880             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    2885                 2890                 2895             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    2900                 2905                 2910             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    2915                 2920                 2925             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    2930                 2935                 2940             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    2945                 2950                 2955             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    2960                 2965                 2970             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    2975                 2980                 2985             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    2990                 2995                 3000             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    3005                 3010                 3015             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    3020                 3025                 3030             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    3035                 3040                 3045             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    3050                 3055                 3060             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    3065                 3070                 3075             


Pro Arg  Asn Pro Ile Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    3080                 3085                 3090             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    3095                 3100                 3105             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    3110                 3115                 3120             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    3125                 3130                 3135             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    3140                 3145                 3150             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    3155                 3160                 3165             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    3170                 3175                 3180             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    3185                 3190                 3195             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    3200                 3205                 3210             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    3215                 3220                 3225             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    3230                 3235                 3240             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    3245                 3250                 3255             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    3260                 3265                 3270             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    3275                 3280                 3285             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    3290                 3295                 3300             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    3305                 3310                 3315             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    3320                 3325                 3330             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    3335                 3340                 3345         


<210>  130
<211>  11697
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-Ser

<400>  130
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctggc ctaccccagg aaattaaaca cacgccggcg     1560

gttcggacca catccgaaga tccaattgcc atagtatcca tggcttgccg gttacccggt     1620

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     1680

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     1740

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     1800

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     1860

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     1920

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     1980

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     2040

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     2100

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     2160

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     2220

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     2280

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     2340

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     2400

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     2460

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     2520

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     2580

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     2640

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     2700

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     2760

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     2820

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     2880

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     2940

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     3000

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     3060

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     3120

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     3180

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     3240

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     3300

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     3360

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     3420

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     3480

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     3540

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     3600

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     3660

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     3720

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     3780

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     3840

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     3900

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     3960

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     4020

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     4080

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     4140

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     4200

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     4260

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     4320

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     4380

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     4440

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     4500

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     4560

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     4620

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     4680

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     4740

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     4800

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     4860

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     4920

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     4980

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     5040

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     5100

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     5160

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     5220

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     5280

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     5340

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     5400

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     5460

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     5520

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     5580

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     5640

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     5700

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     5760

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     5820

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     5880

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     5940

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     6000

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     6060

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     6120

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     6180

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     6240

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     6300

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     6360

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     6420

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat     6480

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac     6540

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg     6600

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga     6660

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac     6720

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa     6780

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct     6840

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga     6900

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt     6960

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt     7020

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg     7080

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca     7140

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc     7200

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac     7260

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa     7320

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag     7380

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta     7440

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta     7500

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga     7560

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca     7620

accccacttg cggttgcgga acatctacgt gatcgtctat tggcttccgc tcgtgctccg     7680

cgtgacgtcc gccaaacagc tcacgctgac gctgctgaac cggctggcga cgacggcctt     7740

cagcacttgc ccttagtagc tgcgcaacct ggaatatgga tggccgagaa gttatctgaa     7800

ctaccatcag cgtggagcgt agcgcattac gtggagctca ctggtgaggt tgactcgcct     7860

cttttggcca gggcggtagt ggctggcctt gcacaagctg acaccttaag aatgcgtttc     7920

acagaggata atggggaagt ttggcaatgg gtagacgatg cgttaacatt tgagttaccg     7980

gaaatcatag acctgcgcac taacatagac cctcacggga cagctcaggc cttgatgcaa     8040

gcggacctgc aacaggacct acgtgtggat tcggggaagc ctctggtctt ccatcagcta     8100

attcaagtag cggacaatcg ctggtactgg tatcaaaggt accaccactt gcttgtggac     8160

gggttcagtt ttccagcgat aaccaggcaa atagccaaca tttattgcac ttggttgcga     8220

ggagagccta cgcccgcatc ccccttcacg ccattcgcag acgttgttga ggaataccaa     8280

cagtatcgcg agagcgaagc gtggcaacgc gatgcggcat tctgggcgga gcaacgacgg     8340

caactaccgc ctcccgcatc cctatcacct gccccgctcc ccggccggtc cgcgtcagcc     8400

gacattctac ggctaaagct ggagttcaca gatggtgaat ttcgacagct tgctacacaa     8460

ctcagcgggg tacaaaggac agacctagcg ctcgctctgg ctgcattatg gctaggacga     8520

ctttgcaatc gaatggacta cgcggcgggt ttcatattta tgcgccggct cggcagcgca     8580

gcgttgaccg caacgggtcc agttttaaat gttcttcctt tgggaatcca cataggcaac     8640

ccaagcttct ctgagcttct caccagggtt cgcgaggtcg ccttaggcgc gtatgcacac     8700

caacatattc cttttgagat gttagtagag gcactgcaac cagagcgaaa ccttagccat     8760

actcctctct tccaagtgat gtttgtcctt cagaatgcgc ccgcgtccca attagagtta     8820

accgggatca ccgcaaaccc aattaaggtt aaatcaacta ccacgaagtt cgacctaact     8880

ttaatcatgc aaaacacagc tagcggatta gtaggtgttt gggagtacaa cacggattta     8940

ttcgacgcgt caacgattga gcgaatgaca gggcactttg taaccctcct cgagggcgtt     9000

atcgccaatc cacaacagcc gatctctcaa cttcctattt taactacagt ggagcaacag     9060

caacttttag tcgagtggaa taacacgcaa accgactacc ccgctgataa gtgtatacat     9120

caattattcg aggaacaggt cgagcgcaca ccagacgccg ttgctgtcgt ctttgggaat     9180

cagcaactca gctatcgaga gatgcgcgaa caagtggttg cactcgccaa tttattacgt     9240

gagcggggag tcaagccagg agactccgtt gccgtggcct taccacgctc tgttttctta     9300

acccttgcac tacacgcgat tgtcgaggca ggtgccgcct ggctacctct tgacacagga     9360

tatcctgacg atagattaaa aatgatgctc gaggatgcac ggccttccct tctgatcaca     9420

acagacgatc aattaccccg cttcagtgac gtacctaatc tgacctcact ctgttacaac     9480

gctcccttga cgcctcaagg gagcgcccct ttacagctgt ctcaacctca ccatactgca     9540

tatatcatct ttacaagtgg ttctacggga cgccccaagg gagtaatggt tggtcagact     9600

gcgattgtaa atcgtctgtt gtggatgcaa aaccactacc ctttgacggg ggaggacgtt     9660

gtagcccaaa agactccttg ctcgttcgat gtctcagtct gggagttctt ttggccattt     9720

atagcagggg ccaaattagt tatggcggag ccggaagccc accgagaccc acttgcgatg     9780

cagcaattct ttgctgagta tggtgtcacc actacacatt tcgtcccatc gatgttagcg     9840

gccttcgtgg cttctcttac tccacaaacg gctaggcaat cttgtgccac actaaagcaa     9900

gtcttctgct ccggcgaggc attacctgca gacttgtgcc gggaatggca gcaactcaca     9960

ggagctccat tgcacaatct atacggaccg accgaggccg cagtagacgt atcttggtat    10020

cctgcgtttg gcgaggagtt agcgcaagta agaggttcgt cagtaccaat aggatacccc    10080

gtatggaaca cggggcttcg gatactggac gcgatgatgc atccggtccc accaggagtc    10140

gcgggcgatt tatacctgac tgggatacag ctggcccaag gttacctagg gagacctgac    10200

cttacggcgt cgaggttcat agcggatccg tttgctccgg gtgagcgcat gtaccgtacg    10260

ggcgacgtcg cgcgatggct agataatggc gccgtagagt atcttggtag atcagacgat    10320

cagttaaaga tacggggaca acgaatagag cttggggaaa tagaccgggt aatgcaggct    10380

ttgccagatg tcgagcaagc ggtggcttcg tgtgctattg cgcgggagga catacctggg    10440

aacaaacacc ttgtagcgta catagttcct caagaggagc aaacatgcac tgagcgatcg    10500

aggtccacac ttacagtttc gttcgtccgg agtttcctta aggagaaact ccccgaatat    10560

atggtaccga gcgcaatagt gattctagac gctctccccc tgactcctaa tggaaagcta    10620

gaccggcggg cgttacccgc ccctgacctg cactcacaac ttgagacaat tattgctgcg    10680

gctttctcga gcctgctcgg gtgcgacgta caagacgcgg atgctgactt tttcgcgcta    10740

ggtggccatt cgctgcttgc catgaagcta gccgctcagc tttcccgaca agtagcgcgg    10800

caggtgacac caggccaagt tatggtagct tcgactgtcg caaagctcgc aacgatcata    10860

gacgcggagt tagataaata cgtcgctcca aggaacccga taacatccgg ggaagataac    10920

cctatccccc tatgtcaagg cgatggggag gagatgagca catggctacg tcgttttgga    10980

cccccagtcg aacatcgggc caggctagtg tgtttccccc acgcaggcgc agcggcggat    11040

tcatacttag acctagcaag agcgttagca ccagagatcg atgttcatgc tgttcaatac    11100

cccggcaggc aagacagaag ggacgaggag ccattaggaa ccgcaggtga aattgcagat    11160

gaagtggcag cggtgctacg tgcgtcggga ggggatgggc cttttgcact tttcggccac    11220

agtatgggcg ccctcatcgc gtacgagaca gcaaggcgat tagagaggga accgggaggg    11280

ggacccttac gtttattcgt gagcggacaa acagcgccac gtgtccatga acgaagaact    11340

gatctgcccg gtgacgatgg actcgtggac gagcttaggc gacttggcac ctccgaggca    11400

gcgctcgcag acgaagccct gctggctatg tctctcccgg tgctcagggc ggattatagg    11460

gtgttaagat cctacgcttg ggcggatggt cccccactac gcgccggtat aactgccctc    11520

tgcggtgatg cagacccact aactgcaaca ggggatgcgg aacgctggtt acaacattcc    11580

gtgattccgg gtcggacacg gacatttccc ggtgggcatt tttatttagg ggaacaagtg    11640

accgaggtgg caggggctgt ccgtagagat ttactgagag cagggttagc gggttga       11697


<210>  131
<211>  3898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-MalH-Ser

<400>  131

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Gly Leu Pro 
            500                 505                 510         


Gln Glu Ile Lys His Thr Pro Ala Val Arg Thr Thr Ser Glu Asp Pro 
        515                 520                 525             


Ile Ala Ile Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val Asn Thr 
    530                 535                 540                 


Pro Gln Arg Leu Trp Glu Leu Leu Arg Glu Gly Gly Glu Thr Leu Ser 
545                 550                 555                 560 


Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Arg Leu His His Pro 
                565                 570                 575     


Asp Pro Asp Asn Pro Gly Thr Ser Tyr Val Asp Lys Gly Gly Phe Leu 
            580                 585                 590         


Asp Asp Ala Ala Gly Phe Asp Ala Glu Phe Phe Gly Val Ser Pro Arg 
        595                 600                 605             


Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
    610                 615                 620                 


Trp Glu Leu Val Glu Asn Ala Gly Ile Asp Pro His Ser Leu Arg Gly 
625                 630                 635                 640 


Thr Ala Thr Gly Val Phe Leu Gly Val Ala Lys Phe Gly Tyr Gly Glu 
                645                 650                 655     


Asp Thr Ala Ala Ala Glu Asp Val Glu Gly Tyr Ser Val Thr Gly Val 
            660                 665                 670         


Ala Pro Ala Val Ala Ser Gly Arg Ile Ser Tyr Thr Met Gly Leu Glu 
        675                 680                 685             


Gly Pro Ser Ile Ser Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
    690                 695                 700                 


Leu His Leu Ala Val Glu Ser Leu Arg Lys Gly Glu Ser Ser Met Ala 
705                 710                 715                 720 


Val Val Gly Gly Ala Ala Val Met Ala Thr Pro Gly Val Phe Val Asp 
                725                 730                 735     


Phe Ser Arg Gln Arg Ala Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
            740                 745                 750         


Gly Ala Gly Ala Asp Gly Phe Gly Phe Ser Glu Gly Val Thr Leu Val 
        755                 760                 765             


Leu Leu Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His Glu Val Leu 
    770                 775                 780                 


Ala Val Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly 
785                 790                 795                 800 


Leu Ser Ala Pro Ser Gly Pro Ala Gln Arg Arg Val Ile Arg Gln Ala 
                805                 810                 815     


Leu Glu Ser Cys Gly Leu Glu Pro Gly Asp Val Asp Ala Val Glu Ala 
            820                 825                 830         


His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Asn Ala Leu 
        835                 840                 845             


Leu Asp Thr Tyr Gly Arg Asp Arg Asp Ala Asp Arg Pro Leu Trp Leu 
    850                 855                 860                 


Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 
865                 870                 875                 880 


Thr Gly Leu Leu Lys Val Val Leu Ala Leu Arg Asn Gly Glu Leu Pro 
                885                 890                 895     


Ala Thr Leu His Val Glu Glu Pro Thr Pro His Val Asp Trp Ser Ser 
            900                 905                 910         


Gly Gly Val Ala Leu Leu Ala Gly Asn Gln Pro Trp Arg Arg Gly Glu 
        915                 920                 925             


Arg Thr Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
    930                 935                 940                 


Ala His Val Ile Val Glu Glu Ala Pro Gln Glu Val Arg Pro Ala Pro 
945                 950                 955                 960 


Gly Gln Gly Leu Ser Pro Ala Val Ser Thr Leu Val Val Ala Gly Lys 
                965                 970                 975     


Thr Met Gln Arg Val Ser Ala Thr Ala Gly Met Leu Ala Asp Trp Met 
            980                 985                 990         


Glu Gly Pro Gly Ala Asp Val Ala  Leu Ala Asp Val Ala  His Thr Leu 
        995                 1000                 1005             


Asn His  His Arg Ser Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala 
    1010                 1015                 1020             


Arg Asp  Arg Thr Gln Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1025                 1030                 1035             


Gly Gln  His Ala Pro Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro 
    1040                 1045                 1050             


Gly Pro  Gly Thr Val Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg 
    1055                 1060                 1065             


Ala Gly  Met Gly Glu Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala 
    1070                 1075                 1080             


Arg Ile  His Gln Gln Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu 
    1085                 1090                 1095             


Asp Val  Asn Glu Thr Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu 
    1100                 1105                 1110             


Gln Val  Ala Leu Phe Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro 
    1115                 1120                 1125             


Asp Ala  Val Val Gly His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr 
    1130                 1135                 1140             


Val Ser  Gly Leu Trp Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser 
    1145                 1150                 1155             


Ala Arg  Ala Arg Leu Met Gln  Ala Leu Pro Ala Gly  Gly Val Met 
    1160                 1165                 1170             


Ala Ala  Val Pro Val Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly 
    1175                 1180                 1185             


Glu Gly  Val Glu Ile Ala Ala  Val Asn Gly Pro Ser  Ser Val Val 
    1190                 1195                 1200             


Leu Ser  Gly Asp Glu Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu 
    1205                 1210                 1215             


Gly Lys  Trp Thr Arg Leu Pro  Thr Ser His Ala Phe  His Ser Ala 
    1220                 1225                 1230             


Arg Met  Glu Pro Met Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly 
    1235                 1240                 1245             


Leu Thr  Tyr Arg Thr Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln 
    1250                 1255                 1260             


Val Met  Thr Ala Glu Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val 
    1265                 1270                 1275             


Arg Phe  Gly Glu Gln Val Ala  Ser Phe Glu Asp Ala  Val Phe Val 
    1280                 1285                 1290             


Glu Leu  Gly Ala Asp Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile 
    1295                 1300                 1305             


Ala Met  Leu His Gly Asp His  Glu Ala Gln Ala Gly  Met Arg Arg 
    1310                 1315                 1320             


Glu Gln  Pro Leu Pro Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu 
    1325                 1330                 1335             


His Asn  Ala Gly Ala Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln 
    1340                 1345                 1350             


Gly Arg  Leu Val Asp Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe 
    1355                 1360                 1365             


Leu Phe  Tyr Asp Arg Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly 
    1370                 1375                 1380             


Ser Thr  Val Ala Val His Pro  Leu Leu Leu Ala Ala  Val Asp Val 
    1385                 1390                 1395             


Pro Gly  His Gly Gly Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp 
    1400                 1405                 1410             


Glu Gln  Pro Trp Leu Ala Glu  His Val Val Gly Gly  Arg Thr Leu 
    1415                 1420                 1425             


Val Pro  Gly Ser Val Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu 
    1430                 1435                 1440             


Asp Val  Gly Leu Pro Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro 
    1445                 1450                 1455             


Leu Val  Leu Ala Gly Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Glu Ser Gly Arg  Arg Thr Ile Asp Val  His Ala Ala 
    1475                 1480                 1485             


Glu Asp  Val Ala Asp Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala 
    1490                 1495                 1500             


Thr Gly  Thr Leu Ala Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr 
    1505                 1510                 1515             


Glu Gln  Trp Pro Pro Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp 
    1520                 1525                 1530             


His Tyr  Asp Gly Leu Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser 
    1535                 1540                 1545             


Phe Gln  Ala Leu Val Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr 
    1550                 1555                 1560             


Met Leu  Ala Glu Val Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln 
    1565                 1570                 1575             


Gly Leu  Tyr Ala Ile His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln 
    1580                 1585                 1590             


Ser Val  Gly Ala His Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu 
    1595                 1600                 1605             


Leu Val  Pro Leu Gly Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val 
    1610                 1615                 1620             


Arg Thr  Ala Arg Tyr Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu 
    1625                 1630                 1635             


Ala Gly  Val Glu Ala Asp Ile  Asp Val Leu Asp Ala  His Gly Thr 
    1640                 1645                 1650             


Val Leu  Leu Ala Val Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser 
    1655                 1660                 1665             


Glu Arg  Asp Lys His Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr 
    1670                 1675                 1680             


Ile Glu  Trp His Gln Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly 
    1685                 1690                 1695             


Ala Gly  Lys Trp Leu Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val 
    1700                 1705                 1710             


Thr Ala  Thr Arg Leu Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala 
    1715                 1720                 1725             


Cys Thr  Thr Met Arg Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala 
    1730                 1735                 1740             


Ala Asp  Gln Leu Arg Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly 
    1745                 1750                 1755             


Val Val  Val Leu Thr Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly 
    1760                 1765                 1770             


Ser Ala  Asp Arg Gly Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile 
    1775                 1780                 1785             


Ala Arg  Glu Leu Ser Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr 
    1790                 1795                 1800             


Val Val  Thr Arg Gly Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val 
    1805                 1810                 1815             


Asn Leu  Glu Gln Gly Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly 
    1820                 1825                 1830             


Ala Glu  His Pro His Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu 
    1835                 1840                 1845             


Gln Thr  Gly Val Glu Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser 
    1850                 1855                 1860             


Glu Glu  Asp Glu Thr Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala 
    1865                 1870                 1875             


Arg Leu  Cys Pro Thr Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile 
    1880                 1885                 1890             


Val Ala  Asp His Gln Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr 
    1895                 1900                 1905             


Pro Gly  Ala Ile Asp Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val 
    1910                 1915                 1920             


Glu Gln  Pro Leu Arg Ala Gly  Glu Val Arg Val Asp  Val Arg Ala 
    1925                 1930                 1935             


Thr Gly  Val Asn Phe Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr 
    1940                 1945                 1950             


Pro Gln  Lys Ala Asp Met Gly  Thr Glu Ala Ala Gly  Val Val Thr 
    1955                 1960                 1965             


Ala Val  Gly Pro Asp Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val 
    1970                 1975                 1980             


Leu Gly  Leu Phe Gln Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp 
    1985                 1990                 1995             


His Arg  Leu Leu Ala Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp 
    2000                 2005                 2010             


Ala Ala  Ala Val Pro Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu 
    2015                 2020                 2025             


His Asp  Leu Ala Gly Leu Arg  Ala Gly Gln Ser Val  Leu Ile His 
    2030                 2035                 2040             


Ala Ala  Ala Gly Gly Val Gly  Met Ala Ala Val Ala  Leu Ala Arg 
    2045                 2050                 2055             


Arg Ala  Gly Ala Glu Val Leu  Ala Thr Ala Gly Pro  Ala Lys His 
    2060                 2065                 2070             


Gly Thr  Leu Arg Ala Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser 
    2075                 2080                 2085             


Ser Arg  Glu Thr Gly Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly 
    2090                 2095                 2100             


Gly Arg  Gly Val Asp Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu 
    2105                 2110                 2115             


Leu Asp  Glu Ser Ala Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val 
    2120                 2125                 2130             


Glu Met  Gly Lys Thr Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Phe Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu 
    2150                 2155                 2160             


Gly Glu  Ile Leu Arg Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu 
    2165                 2170                 2175             


Leu Asp  Arg Leu Pro Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln 
    2180                 2185                 2190             


Thr Gly  Lys Ser Leu Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val 
    2195                 2200                 2205             


Phe Arg  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr 
    2210                 2215                 2220             


Leu Gly  Arg Leu Leu Ala Arg  His Leu Val Thr Glu  His Gly Val 
    2225                 2230                 2235             


Arg His  Leu Leu Leu Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly 
    2240                 2245                 2250             


Ser Asp  Glu Leu Arg Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala 
    2255                 2260                 2265             


Glu Ile  Ala Ala Cys Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala 
    2270                 2275                 2280             


Leu Leu  Asp Gly Leu Pro Arg  Pro Leu Thr Gly Val  Val His Ala 
    2285                 2290                 2295             


Ala Gly  Val Leu Ala Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro 
    2300                 2305                 2310             


Ala Val  Glu Gln Val Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn 
    2315                 2320                 2325             


Leu His  Glu Leu Thr Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu 
    2330                 2335                 2340             


Phe Ser  Ser Ala Ala Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val 
    2345                 2350                 2355             


Tyr Ala  Ala Ala Asn Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg 
    2360                 2365                 2370             


Arg Thr  Arg Gly Leu Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp 
    2375                 2380                 2385             


Ala Ile  Gly Arg Ala Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala 
    2390                 2395                 2400             


Ile Ala  Pro Glu Glu Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg 
    2405                 2410                 2415             


His Asn  Arg Ala Tyr Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro 
    2420                 2425                 2430             


Trp Leu  Thr Ala Phe Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe 
    2435                 2440                 2445             


Gln Ser  Leu Gly Gln Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala 
    2450                 2455                 2460             


Glu Leu  Val Asp Leu Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg 
    2465                 2470                 2475             


Arg Leu  Leu Glu Leu Val Arg  Ser His Ala Ala Ala  Val Ser Gly 
    2480                 2485                 2490             


Tyr Gly  Ser Ala Asp Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp 
    2495                 2500                 2505             


Leu Gly  Phe Asp Ser Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu 
    2510                 2515                 2520             


Gly Thr  Ala Thr Gly Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp 
    2525                 2530                 2535             


His Pro  Thr Pro Leu Ala Val  Ala Glu His Leu Arg  Asp Arg Leu 
    2540                 2545                 2550             


Leu Ala  Ser Ala Arg Ala Pro  Arg Asp Val Arg Gln  Thr Ala His 
    2555                 2560                 2565             


Ala Asp  Ala Ala Glu Pro Ala  Gly Asp Asp Gly Leu  Gln His Leu 
    2570                 2575                 2580             


Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp Met Ala  Glu Lys Leu 
    2585                 2590                 2595             


Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala His Tyr  Val Glu Leu 
    2600                 2605                 2610             


Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala Arg Ala  Val Val Ala 
    2615                 2620                 2625             


Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met Arg Phe  Thr Glu Asp 
    2630                 2635                 2640             


Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp Ala Leu  Thr Phe Glu 
    2645                 2650                 2655             


Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn Ile Asp  Pro His Gly 
    2660                 2665                 2670             


Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu Gln Gln  Asp Leu Arg 
    2675                 2680                 2685             


Val Asp  Ser Gly Lys Pro Leu  Val Phe His Gln Leu  Ile Gln Val 
    2690                 2695                 2700             


Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg Tyr His  His Leu Leu 
    2705                 2710                 2715             


Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr Arg Gln  Ile Ala Asn 
    2720                 2725                 2730             


Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro Thr Pro  Ala Ser Pro 
    2735                 2740                 2745             


Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu Tyr Gln  Gln Tyr Arg 
    2750                 2755                 2760             


Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala Phe Trp  Ala Glu Gln 
    2765                 2770                 2775             


Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu Ser Pro  Ala Pro Leu 
    2780                 2785                 2790             


Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu Arg Leu  Lys Leu Glu 
    2795                 2800                 2805             


Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala Thr Gln  Leu Ser Gly 
    2810                 2815                 2820             


Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu Ala Ala  Leu Trp Leu 
    2825                 2830                 2835             


Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala Ala Gly  Phe Ile Phe 
    2840                 2845                 2850             


Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr Ala Thr  Gly Pro Val 
    2855                 2860                 2865             


Leu Asn  Val Leu Pro Leu Gly  Ile His Ile Gly Asn  Pro Ser Phe 
    2870                 2875                 2880             


Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val Ala Leu  Gly Ala Tyr 
    2885                 2890                 2895             


Ala His  Gln His Ile Pro Phe  Glu Met Leu Val Glu  Ala Leu Gln 
    2900                 2905                 2910             


Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu Phe Gln  Val Met Phe 
    2915                 2920                 2925             


Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu Glu Leu  Thr Gly Ile 
    2930                 2935                 2940             


Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr Thr Thr  Lys Phe Asp 
    2945                 2950                 2955             


Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser Gly Leu  Val Gly Val 
    2960                 2965                 2970             


Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala Ser Thr  Ile Glu Arg 
    2975                 2980                 2985             


Met Thr  Gly His Phe Val Thr  Leu Leu Glu Gly Val  Ile Ala Asn 
    2990                 2995                 3000             


Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile Leu Thr  Thr Val Glu 
    3005                 3010                 3015             


Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn Thr Gln  Thr Asp Tyr 
    3020                 3025                 3030             


Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe Glu Glu  Gln Val Glu 
    3035                 3040                 3045             


Arg Thr  Pro Asp Ala Val Ala  Val Val Phe Gly Asn  Gln Gln Leu 
    3050                 3055                 3060             


Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val Ala Leu  Ala Asn Leu 
    3065                 3070                 3075             


Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp Ser Val  Ala Val Ala 
    3080                 3085                 3090             


Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala Leu His  Ala Ile Val 
    3095                 3100                 3105             


Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp Thr Gly  Tyr Pro Asp 
    3110                 3115                 3120             


Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala Arg Pro  Ser Leu Leu 
    3125                 3130                 3135             


Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe Ser Asp  Val Pro Asn 
    3140                 3145                 3150             


Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu Thr Pro  Gln Gly Ser 
    3155                 3160                 3165             


Ala Pro  Leu Gln Leu Ser Gln  Pro His His Thr Ala  Tyr Ile Ile 
    3170                 3175                 3180             


Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys Gly Val  Met Val Gly 
    3185                 3190                 3195             


Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp Met Gln  Asn His Tyr 
    3200                 3205                 3210             


Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln Lys Thr  Pro Cys Ser 
    3215                 3220                 3225             


Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp Pro Phe  Ile Ala Gly 
    3230                 3235                 3240             


Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala His Arg  Asp Pro Leu 
    3245                 3250                 3255             


Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly Val Thr  Thr Thr His 
    3260                 3265                 3270             


Phe Val  Pro Ser Met Leu Ala  Ala Phe Val Ala Ser  Leu Thr Pro 
    3275                 3280                 3285             


Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu Lys Gln  Val Phe Cys 
    3290                 3295                 3300             


Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys Arg Glu  Trp Gln Gln 
    3305                 3310                 3315             


Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr Gly Pro  Thr Glu Ala 
    3320                 3325                 3330             


Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe Gly Glu  Glu Leu Ala 
    3335                 3340                 3345             


Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly Tyr Pro  Val Trp Asn 
    3350                 3355                 3360             


Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met His Pro  Val Pro Pro 
    3365                 3370                 3375             


Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly Ile Gln  Leu Ala Gln 
    3380                 3385                 3390             


Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala Ser Arg  Phe Ile Ala 
    3395                 3400                 3405             


Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Val 
    3410                 3415                 3420             


Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu Tyr Leu  Gly Arg Ser 
    3425                 3430                 3435             


Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    3440                 3445                 3450             


Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp Val Glu  Gln Ala Val 
    3455                 3460                 3465             


Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile Pro Gly  Asn Lys His 
    3470                 3475                 3480             


Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu Gln Thr  Cys Thr Glu 
    3485                 3490                 3495             


Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe Val Arg  Ser Phe Leu 
    3500                 3505                 3510             


Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro Ser Ala  Ile Val Ile 
    3515                 3520                 3525             


Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly Lys Leu  Asp Arg Arg 
    3530                 3535                 3540             


Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln Leu Glu  Thr Ile Ile 
    3545                 3550                 3555             


Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys Asp Val  Gln Asp Ala 
    3560                 3565                 3570             


Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His Ser Leu  Leu Ala Met 
    3575                 3580                 3585             


Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val Ala Arg  Gln Val Thr 
    3590                 3595                 3600             


Pro Gly  Gln Val Met Val Ala  Ser Thr Val Ala Lys  Leu Ala Thr 
    3605                 3610                 3615             


Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val Ala Pro  Arg Asn Pro 
    3620                 3625                 3630             


Ile Thr  Ser Gly Glu Asp Asn  Pro Ile Pro Leu Cys  Gln Gly Asp 
    3635                 3640                 3645             


Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg Phe Gly  Pro Pro Val 
    3650                 3655                 3660             


Glu His  Arg Ala Arg Leu Val  Cys Phe Pro His Ala  Gly Ala Ala 
    3665                 3670                 3675             


Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala Leu Ala  Pro Glu Ile 
    3680                 3685                 3690             


Asp Val  His Ala Val Gln Tyr  Pro Gly Arg Gln Asp  Arg Arg Asp 
    3695                 3700                 3705             


Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile Ala Asp  Glu Val Ala 
    3710                 3715                 3720             


Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly Pro Phe  Ala Leu Phe 
    3725                 3730                 3735             


Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr Glu Thr  Ala Arg Arg 
    3740                 3745                 3750             


Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu Arg Leu  Phe Val Ser 
    3755                 3760                 3765             


Gly Gln  Thr Ala Pro Arg Val  His Glu Arg Arg Thr  Asp Leu Pro 
    3770                 3775                 3780             


Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg Arg Leu  Gly Thr Ser 
    3785                 3790                 3795             


Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu Ala Met  Ser Leu Pro 
    3800                 3805                 3810             


Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg Ser Tyr  Ala Trp Ala 
    3815                 3820                 3825             


Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr Ala Leu  Cys Gly Asp 
    3830                 3835                 3840             


Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala Glu Arg  Trp Leu Gln 
    3845                 3850                 3855             


His Ser  Val Ile Pro Gly Arg  Thr Arg Thr Phe Pro  Gly Gly His 
    3860                 3865                 3870             


Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val Ala Gly  Ala Val Arg 
    3875                 3880                 3885             


Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    3890                 3895             


<210>  132
<211>  10341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-MalOH

<400>  132
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg ccattcagac aggcgcatca     1860

ctgtcaattc cggcaatcca atcgcgcagc aaccgtgacc agcacttgcc cttagtagct     1920

gcgcaacctg gaatatggat ggccgagaag ttatctgaac taccatcagc gtggagcgta     1980

gcgcattacg tggagctcac tggtgaggtt gactcgcctc ttttggccag ggcggtagtg     2040

gctggccttg cacaagctga caccttaaga atgcgtttca cagaggataa tggggaagtt     2100

tggcaatggg tagacgatgc gttaacattt gagttaccgg aaatcataga cctgcgcact     2160

aacatagacc ctcacgggac agctcaggcc ttgatgcaag cggacctgca acaggaccta     2220

cgtgtggatt cggggaagcc tctggtcttc catcagctaa ttcaagtagc ggacaatcgc     2280

tggtactggt atcaaaggta ccaccacttg cttgtggacg ggttcagttt tccagcgata     2340

accaggcaaa tagccaacat ttattgcact tggttgcgag gagagcctac gcccgcatcc     2400

cccttcacgc cattcgcaga cgttgttgag gaataccaac agtatcgcga gagcgaagcg     2460

tggcaacgcg atgcggcatt ctgggcggag caacgacggc aactaccgcc tcccgcatcc     2520

ctatcacctg ccccgctccc cggccggtcc gcgtcagccg acattctacg gctaaagctg     2580

gagttcacag atggtgaatt tcgacagctt gctacacaac tcagcggggt acaaaggaca     2640

gacctagcgc tcgctctggc tgcattatgg ctaggacgac tttgcaatcg aatggactac     2700

gcggcgggtt tcatatttat gcgccggctc ggcagcgcag cgttgaccgc aacgggtcca     2760

gttttaaatg ttcttccttt gggaatccac ataggcaacc caagcttctc tgagcttctc     2820

accagggttc gcgaggtcgc cttaggcgcg tatgcacacc aacatattcc ttttgagatg     2880

ttagtagagg cactgcaacc agagcgaaac cttagccata ctcctctctt ccaagtgatg     2940

tttgtccttc agaatgcgcc cgcgtcccaa ttagagttaa ccgggatcac cgcaaaccca     3000

attaaggtta aatcaactac cacgaagttc gacctaactt taatcatgca aaacacagct     3060

agcggattag taggtgtttg ggagtacaac acggatttat tcgacgcgtc aacgattgag     3120

cgaatgacag ggcactttgt aaccctcctc gagggcgtta tcgccaatcc acaacagccg     3180

atctctcaac ttcctatttt aactacagtg gagcaacagc aacttttagt cgagtggaat     3240

aacacgcaaa ccgactaccc cgctgataag tgtatacatc aattattcga ggaacaggtc     3300

gagcgcacac cagacgccgt tgctgtcgtc tttgggaatc agcaactcag ctatcgagag     3360

atgcgcgaac aagtggttgc actcgccaat ttattacgtg agcggggagt caagccagga     3420

gactccgttg ccgtggcctt accacgctct gttttcttaa cccttgcact acacgcgatt     3480

gtcgaggcag gtgccgcctg gctacctctt gacacaggat atcctgacga tagattaaaa     3540

atgatgctcg aggatgcacg gccttccctt ctgatcacaa cagacgatca attaccccgc     3600

ttcagtgacg tacctaatct gacctcactc tgttacaacg ctcccttgac gcctcaaggg     3660

agcgcccctt tacagctgtc tcaacctcac catactgcat atatcatctt tacaagtggt     3720

tctacgggac gccccaaggg agtaatggtt ggtcagactg cgattgtaaa tcgtctgttg     3780

tggatgcaaa accactaccc tttgacgggg gaggacgttg tagcccaaaa gactccttgc     3840

tcgttcgatg tctcagtctg ggagttcttt tggccattta tagcaggggc caaattagtt     3900

atggcggagc cggaagccca ccgagaccca cttgcgatgc agcaattctt tgctgagtat     3960

ggtgtcacca ctacacattt cgtcccatcg atgttagcgg ccttcgtggc ttctcttact     4020

ccacaaacgg ctaggcaatc ttgtgccaca ctaaagcaag tcttctgctc cggcgaggca     4080

ttacctgcag acttgtgccg ggaatggcag caactcacag gagctccatt gcacaatcta     4140

tacggaccga ccgaggccgc agtagacgta tcttggtatc ctgcgtttgg cgaggagtta     4200

gcgcaagtaa gaggttcgtc agtaccaata ggataccccg tatggaacac ggggcttcgg     4260

atactggacg cgatgatgca tccggtccca ccaggagtcg cgggcgattt atacctgact     4320

gggatacagc tggcccaagg ttacctaggg agacctgacc ttacggcgtc gaggttcata     4380

gcggatccgt ttgctccggg tgagcgcatg taccgtacgg gcgacgtcgc gcgatggcta     4440

gataatggcg ccgtagagta tcttggtaga tcagacgatc agttaaagat acggggacaa     4500

cgaatagagc ttggggaaat agaccgggta atgcaggctt tgccagatgt cgagcaagcg     4560

gtggcttcgt gtgctattgc gcgggaggac atacctggga acaaacacct tgtagcgtac     4620

atagttcctc aagaggagca aacatgcact gagcgatcga ggtccacact tacagtttcg     4680

ttcgtccgga gtttccttaa ggagaaactc cccgaatata tggtaccgag cgcaatagtg     4740

attctagacg ctctccccct gactcctaat ggaaagctag accggcgggc gttacccgcc     4800

cctgacctgc actcacaact tgagacaatt attgctgcgg ctttctcgag cctgctcggg     4860

tgcgacgtac aagacgcgga tgctgacttt ttcgcgctag gtggccattc gctgcttgcc     4920

atgaagctag ccgctcagct ttcccgacaa gtagcgcggc aggtgacacc aggccaagtt     4980

atggtagctt cgactgtcgc aaagctcgca acgatcatag acgcggagtt agataaatac     5040

gtcgctccaa ggaacccgat acctggaatt ggggcgctag ttcccgctcc cgtggtaatc     5100

gcagcaggcc gtacggagga accaattgcc atcgtttcga tggcatgtcg tttaccggga     5160

ggagtcaata cgccccaacg gctctgggaa ttactacggg agggtggtga aaccttgtcc     5220

gggttcccaa cggaccgtgg ctgggaccta gcacggcttc accaccctga tccggacaac     5280

cccggaacga gctacgttga taagggtgga tttctcgacg acgcggcggg tttcgacgca     5340

gagtttttcg gggtttcacc aagggaagct gccgctatgg accctcagca acgattactt     5400

ttagagacct cgtgggagct agttgaaaat gcgggcatag atccacatag cctgcgaggg     5460

acagcgacag gggtgttcct aggagttgcg aagtttggtt atggtgagga cacagcagca     5520

gcggaagatg ttgaaggtta ttcagttacc ggtgttgctc ccgctgtggc atctggccgc     5580

atatcctaca ctatgggttt agaaggtcct tccatctcgg tcgataccgc atgctcaagc     5640

tcgctagtcg cgcttcatct agccgtagag tccctccgaa agggtgagtc atctatggcg     5700

gtggtgggtg gtgcagccgt tatggcgact cctggggtat ttgttgattt ttcacgccaa     5760

cgggcgcttg ccgcagacgg ccgttccaaa gcgttcgggg caggtgcaga tggttttggt     5820

ttcagcgagg gagtcacgct ggttctacta gagcgtttaa gtgaggcgcg tcgtaacggt     5880

catgaagttc tagctgtagt gcgcgggtcc gcgttaaacc aggacggagc gagcaacgga     5940

ctttcagcac cctccggccc tgcgcaacgt agagtaataa ggcaagcgct cgaatcgtgt     6000

gggcttgaac cgggggatgt tgacgcggtt gaggcgcatg gtactggtac agcactaggt     6060

gacccaatag aggccaatgc gctgttggac acttacgggc gagaccgtga tgcggatcgt     6120

ccactttggt tggggtccgt taagagcaat attgggcaca ctcaagctgc ggccggggtt     6180

acaggactgc tgaaggttgt gttagcactg cgcaatggtg agctacctgc aacgttacat     6240

gtcgaggaac caactccaca cgtcgattgg tcctcaggtg gtgtcgcatt actggcgggt     6300

aatcaaccat ggcgaagggg agaaaggacc agaagggcgg cagtgagcgc ctttggtatc     6360

tccggtacaa atgctcacgt gatagtggaa gaggcgcctc aggaagttcg acccgcccct     6420

ggccaagggc tgtcgccagc cgtgtccacg ttagttgttg caggtaaaac catgcagcgt     6480

gtaagtgcga cagctggaat gcttgcagac tggatggagg gtcctggggc cgatgttgca     6540

ttggcggatg tggcccatac cctgaaccat caccgatcaa gacagcccaa gttcgggacg     6600

gttgtagcgc gtgacaggac tcaggcgata gctgggctcc gtgcattggc ggctggtcaa     6660

catgctcctg gggtcgtcaa cccagctgaa ggttccccag gaccaggcac cgtgttcgtt     6720

tttcccggtc aaggttcgca gagggcaggg atgggggagg aactcgcggc agcctttcct     6780

gtcttcgctc gaatacatca gcaagtttgg gacctcctag atgttcccga cctcgacgtt     6840

aatgaaaccg ggtacgccca accagcgctg ttcgcgcttc aggtcgcgct ctttggcctt     6900

ctggagtcgt ggggtgttag gccagatgca gtggtagggc actcagttgg tgagctggcc     6960

gcggggtacg tgtccggtct ttggtcacta gaggacgcct gcacactagt ctcagcaaga     7020

gcgcgcctaa tgcaggcact gcctgctgga ggggtgatgg cggcagtccc cgtctccgag     7080

gatgaggcgc gggccgtcct gggcgaggga gttgaaattg cggctgtgaa tggaccctcg     7140

tccgttgtgc tctcagggga cgaggcggca gtcttacagg ccgccgaagg tctaggtaag     7200

tggacgcgac tgccgaccag ccatgctttt cactcagcga gaatggaacc catgctagaa     7260

gagtttcggg ccgtagcaga gggtctgacc tatcgtaccc ctcaagtagc tatggctgct     7320

ggggatcagg tgatgacagc agaatattgg gtgcggcagg ttcgggacac agttcgcttc     7380

ggggagcaag tagcgtcatt cgaggatgcg gtgtttgttg agttaggcgc tgacagaagt     7440

ctagcgcgtt tggtggacgg catcgccatg ctgcacggtg accacgaagc gcaggccgcg     7500

gaccataggc aaatcaccga agcggttgcg gatgcttacg tcttaggcca ccttccggat     7560

tttgcggcgc tgcggcggcc tcacgcacga aagttggact taccaactta tcccttcgag     7620

cgtagacagt actggttcag agatgcgcgt gagaggccgg aacaacccag agataccggc     7680

ggacctcgca cagaagcagt ccgtctgtta gaggatggta ggattgaaga attagctgca     7740

cttttgggag gggccagtga tgaccaacac acattacagg tgctgactaa gttggcggcg     7800

caacataacc aacaacgaac aacccggtca atcgctgacg acaggtacga aataaggtgg     7860

gaccgatcga cttccccact atccggagca gatgttgacc aagcggggag ctggatcgtg     7920

gtgtcagatg acgcagatgc cgttcccccg ctagtggact tgctggctgc acgtaacgag     7980

ccccatcagg ttgttggtct acccgcttcg gacgcagacg aggagaggct cgcagagact     8040

ctgcgtgcgg ctgcgactga agatgctacc cttcggatag tccacgttgc ggcgctcgaa     8100

gcaggcgcta cccccagcat gcgttcactg ctccgcatgc agcaccgaat actaggtggc     8160

acgcggcggg tgttcagggc agcggtcgca gcggagttaa gaggtcccat ttggatagtg     8220

acgcggggag cacaaagagt ggctgacacc gatacagttg ccccgcatca gtcatgcctc     8280

tggggatttg ggagggcagc atcgctggag ctgccgcacg tttggggtgg cctagcagat     8340

ttatcagagg gcggtgacaa tgcggccgat gagtggagtg cgctagtgga ccgcattgcc     8400

gcaccccacg gttcagcagt tagggaggac caactggcgc tgagagacag ggccgtatat     8460

acgccaagac tggccagacg ttctgcgccc ccgagcggga ctcccctaca tctacgaggg     8520

gatggcacag tgttaataac aggtgggact ggtacactag gtaggctatt agcgcgtcac     8580

ctagtaacag agcatggggt gcggcatctc ttactagttt caaggagagg cgccgatgcc     8640

cctggctcgg atgaactgcg cgcagaaata gaggacttag gtgccagcgc ggagatcgca     8700

gcgtgtgata cagcggatcg cgatgcccta tctgccctac tagatggtct cccccggccc     8760

cttacgggtg tcgttcacgc cgctggcgtg ttagccgatg gacttgtcac tagcattgac     8820

gagcctgcgg tggaacaggt tctccgagca aaggtggacg cggcatggaa cctacacgaa     8880

ctcacagcta ataccgggct atcctttttc gttcttttct catcagcagc atcggtcctg     8940

gcaggtccag ggcaaggagt ttatgcggct gcaaatgaat cgctcaacgc actagctgcg     9000

ttaaggcgaa ctaggggtct gccggccaag gctctgggat ggggcctgtg ggccatcggg     9060

cgggcaatcg cttttgcgga gcagaccggg gacgccatcg ctccagagga aggagcatac     9120

gcttttgaaa ctctgttaag gcataaccgt gcctactcgg gatatgcgcc cgtcattgga     9180

tctccctggt tgaccgcgtt cgcacagcat tccccctttg cagaaaaatt ccaatcactc     9240

ggacagaatc ggtcagggac atcgaaattc ttagcggagc tagttgacct gcctcgtgag     9300

gaatggccgg ataggctcag gagactacta gagttagtta ggtcccatgc cgccgcggtc     9360

tccggttacg gtagtgcaga tcaactgccg gaaagaaaag cgttcaagga tttggggttt     9420

gattcgctgg ccgccgttga actgcgtaac cggctgggaa cggctacagg ggtacgactg     9480

ccgtcaaccc tagtatttga tcacccaact ccgctggccg tcgctgagca cttaagagat     9540

aggctaacat ccggggaaga taaccctatc cccctatgtc aaggcgatgg ggaggagatg     9600

agcacatggc tacgtcgttt tggaccccca gtcgaacatc gggccaggct agtgtgtttc     9660

ccccacgcag gcgcagcggc ggattcatac ttagacctag caagagcgtt agcaccagag     9720

atcgatgttc atgctgttca ataccccggc aggcaagaca gaagggacga ggagccatta     9780

ggaaccgcag gtgaaattgc agatgaagtg gcagcggtgc tacgtgcgtc gggaggggat     9840

gggccttttg cacttttcgg ccacagtatg ggcgccctca tcgcgtacga gacagcaagg     9900

cgattagaga gggaaccggg agggggaccc ttacgtttat tcgtgagcgg acaaacagcg     9960

ccacgtgtcc atgaacgaag aactgatctg cccggtgacg atggactcgt ggacgagctt    10020

aggcgacttg gcacctccga ggcagcgctc gcagacgaag ccctgctggc tatgtctctc    10080

ccggtgctca gggcggatta tagggtgtta agatcctacg cttgggcgga tggtccccca    10140

ctacgcgccg gtataactgc cctctgcggt gatgcagacc cactaactgc aacaggggat    10200

gcggaacgct ggttacaaca ttccgtgatt ccgggtcgga cacggacatt tcccggtggg    10260

catttttatt taggggaaca agtgaccgag gtggcagggg ctgtccgtag agatttactg    10320

agagcagggt tagcgggttg a                                              10341


<210>  133
<211>  3446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-MalOH

<400>  133

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Ala Ile Gln Thr Gly Ala Ser Leu Ser Ile Pro 
    610                 615                 620                 


Ala Ile Gln Ser Arg Ser Asn Arg Asp Gln His Leu Pro Leu Val Ala 
625                 630                 635                 640 


Ala Gln Pro Gly Ile Trp Met Ala Glu Lys Leu Ser Glu Leu Pro Ser 
                645                 650                 655     


Ala Trp Ser Val Ala His Tyr Val Glu Leu Thr Gly Glu Val Asp Ser 
            660                 665                 670         


Pro Leu Leu Ala Arg Ala Val Val Ala Gly Leu Ala Gln Ala Asp Thr 
        675                 680                 685             


Leu Arg Met Arg Phe Thr Glu Asp Asn Gly Glu Val Trp Gln Trp Val 
    690                 695                 700                 


Asp Asp Ala Leu Thr Phe Glu Leu Pro Glu Ile Ile Asp Leu Arg Thr 
705                 710                 715                 720 


Asn Ile Asp Pro His Gly Thr Ala Gln Ala Leu Met Gln Ala Asp Leu 
                725                 730                 735     


Gln Gln Asp Leu Arg Val Asp Ser Gly Lys Pro Leu Val Phe His Gln 
            740                 745                 750         


Leu Ile Gln Val Ala Asp Asn Arg Trp Tyr Trp Tyr Gln Arg Tyr His 
        755                 760                 765             


His Leu Leu Val Asp Gly Phe Ser Phe Pro Ala Ile Thr Arg Gln Ile 
    770                 775                 780                 


Ala Asn Ile Tyr Cys Thr Trp Leu Arg Gly Glu Pro Thr Pro Ala Ser 
785                 790                 795                 800 


Pro Phe Thr Pro Phe Ala Asp Val Val Glu Glu Tyr Gln Gln Tyr Arg 
                805                 810                 815     


Glu Ser Glu Ala Trp Gln Arg Asp Ala Ala Phe Trp Ala Glu Gln Arg 
            820                 825                 830         


Arg Gln Leu Pro Pro Pro Ala Ser Leu Ser Pro Ala Pro Leu Pro Gly 
        835                 840                 845             


Arg Ser Ala Ser Ala Asp Ile Leu Arg Leu Lys Leu Glu Phe Thr Asp 
    850                 855                 860                 


Gly Glu Phe Arg Gln Leu Ala Thr Gln Leu Ser Gly Val Gln Arg Thr 
865                 870                 875                 880 


Asp Leu Ala Leu Ala Leu Ala Ala Leu Trp Leu Gly Arg Leu Cys Asn 
                885                 890                 895     


Arg Met Asp Tyr Ala Ala Gly Phe Ile Phe Met Arg Arg Leu Gly Ser 
            900                 905                 910         


Ala Ala Leu Thr Ala Thr Gly Pro Val Leu Asn Val Leu Pro Leu Gly 
        915                 920                 925             


Ile His Ile Gly Asn Pro Ser Phe Ser Glu Leu Leu Thr Arg Val Arg 
    930                 935                 940                 


Glu Val Ala Leu Gly Ala Tyr Ala His Gln His Ile Pro Phe Glu Met 
945                 950                 955                 960 


Leu Val Glu Ala Leu Gln Pro Glu Arg Asn Leu Ser His Thr Pro Leu 
                965                 970                 975     


Phe Gln Val Met Phe Val Leu Gln Asn Ala Pro Ala Ser Gln Leu Glu 
            980                 985                 990         


Leu Thr Gly Ile Thr Ala Asn Pro  Ile Lys Val Lys Ser  Thr Thr Thr 
        995                 1000                 1005             


Lys Phe  Asp Leu Thr Leu Ile  Met Gln Asn Thr Ala  Ser Gly Leu 
    1010                 1015                 1020             


Val Gly  Val Trp Glu Tyr Asn  Thr Asp Leu Phe Asp  Ala Ser Thr 
    1025                 1030                 1035             


Ile Glu  Arg Met Thr Gly His  Phe Val Thr Leu Leu  Glu Gly Val 
    1040                 1045                 1050             


Ile Ala  Asn Pro Gln Gln Pro  Ile Ser Gln Leu Pro  Ile Leu Thr 
    1055                 1060                 1065             


Thr Val  Glu Gln Gln Gln Leu  Leu Val Glu Trp Asn  Asn Thr Gln 
    1070                 1075                 1080             


Thr Asp  Tyr Pro Ala Asp Lys  Cys Ile His Gln Leu  Phe Glu Glu 
    1085                 1090                 1095             


Gln Val  Glu Arg Thr Pro Asp  Ala Val Ala Val Val  Phe Gly Asn 
    1100                 1105                 1110             


Gln Gln  Leu Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    1115                 1120                 1125             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    1130                 1135                 1140             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    1145                 1150                 1155             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    1160                 1165                 1170             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    1175                 1180                 1185             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    1190                 1195                 1200             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    1205                 1210                 1215             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    1220                 1225                 1230             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    1235                 1240                 1245             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    1250                 1255                 1260             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    1265                 1270                 1275             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    1280                 1285                 1290             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    1295                 1300                 1305             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    1310                 1315                 1320             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    1325                 1330                 1335             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    1340                 1345                 1350             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    1355                 1360                 1365             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    1370                 1375                 1380             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    1385                 1390                 1395             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    1400                 1405                 1410             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    1415                 1420                 1425             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    1430                 1435                 1440             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    1445                 1450                 1455             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    1460                 1465                 1470             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    1475                 1480                 1485             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    1490                 1495                 1500             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    1505                 1510                 1515             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    1520                 1525                 1530             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    1535                 1540                 1545             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    1550                 1555                 1560             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    1565                 1570                 1575             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    1580                 1585                 1590             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Glu 
    1595                 1600                 1605             


Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val 
    1610                 1615                 1620             


Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu 
    1625                 1630                 1635             


Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg 
    1640                 1645                 1650             


Gln Val  Thr Pro Gly Gln Val  Met Val Ala Ser Thr  Val Ala Lys 
    1655                 1660                 1665             


Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Asp Lys Tyr  Val Ala Pro 
    1670                 1675                 1680             


Arg Asn  Pro Ile Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    1685                 1690                 1695             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    1700                 1705                 1710             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    1715                 1720                 1725             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    1730                 1735                 1740             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    1745                 1750                 1755             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    1760                 1765                 1770             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    1775                 1780                 1785             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    1790                 1795                 1800             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    1805                 1810                 1815             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    1820                 1825                 1830             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    1835                 1840                 1845             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    1850                 1855                 1860             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    1865                 1870                 1875             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    1880                 1885                 1890             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    1895                 1900                 1905             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    1910                 1915                 1920             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    1925                 1930                 1935             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    1940                 1945                 1950             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    1955                 1960                 1965             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    1970                 1975                 1980             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    1985                 1990                 1995             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2000                 2005                 2010             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2015                 2020                 2025             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2030                 2035                 2040             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2045                 2050                 2055             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2060                 2065                 2070             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2075                 2080                 2085             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2090                 2095                 2100             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2105                 2110                 2115             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2120                 2125                 2130             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2135                 2140                 2145             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2150                 2155                 2160             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2165                 2170                 2175             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2180                 2185                 2190             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2195                 2200                 2205             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2210                 2215                 2220             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2225                 2230                 2235             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2240                 2245                 2250             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2255                 2260                 2265             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2270                 2275                 2280             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2285                 2290                 2295             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2300                 2305                 2310             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2315                 2320                 2325             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2330                 2335                 2340             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2345                 2350                 2355             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2360                 2365                 2370             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2375                 2380                 2385             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2390                 2395                 2400             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2405                 2410                 2415             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2420                 2425                 2430             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2435                 2440                 2445             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2450                 2455                 2460             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2465                 2470                 2475             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2480                 2485                 2490             


Asp His  Glu Ala Gln Ala Ala  Asp His Arg Gln Ile  Thr Glu Ala 
    2495                 2500                 2505             


Val Ala  Asp Ala Tyr Val Leu  Gly His Leu Pro Asp  Phe Ala Ala 
    2510                 2515                 2520             


Leu Arg  Arg Pro His Ala Arg  Lys Leu Asp Leu Pro  Thr Tyr Pro 
    2525                 2530                 2535             


Phe Glu  Arg Arg Gln Tyr Trp  Phe Arg Asp Ala Arg  Glu Arg Pro 
    2540                 2545                 2550             


Glu Gln  Pro Arg Asp Thr Gly  Gly Pro Arg Thr Glu  Ala Val Arg 
    2555                 2560                 2565             


Leu Leu  Glu Asp Gly Arg Ile  Glu Glu Leu Ala Ala  Leu Leu Gly 
    2570                 2575                 2580             


Gly Ala  Ser Asp Asp Gln His  Thr Leu Gln Val Leu  Thr Lys Leu 
    2585                 2590                 2595             


Ala Ala  Gln His Asn Gln Gln  Arg Thr Thr Arg Ser  Ile Ala Asp 
    2600                 2605                 2610             


Asp Arg  Tyr Glu Ile Arg Trp  Asp Arg Ser Thr Ser  Pro Leu Ser 
    2615                 2620                 2625             


Gly Ala  Asp Val Asp Gln Ala  Gly Ser Trp Ile Val  Val Ser Asp 
    2630                 2635                 2640             


Asp Ala  Asp Ala Val Pro Pro  Leu Val Asp Leu Leu  Ala Ala Arg 
    2645                 2650                 2655             


Asn Glu  Pro His Gln Val Val  Gly Leu Pro Ala Ser  Asp Ala Asp 
    2660                 2665                 2670             


Glu Glu  Arg Leu Ala Glu Thr  Leu Arg Ala Ala Ala  Thr Glu Asp 
    2675                 2680                 2685             


Ala Thr  Leu Arg Ile Val His  Val Ala Ala Leu Glu  Ala Gly Ala 
    2690                 2695                 2700             


Thr Pro  Ser Met Arg Ser Leu  Leu Arg Met Gln His  Arg Ile Leu 
    2705                 2710                 2715             


Gly Gly  Thr Arg Arg Val Phe  Arg Ala Ala Val Ala  Ala Glu Leu 
    2720                 2725                 2730             


Arg Gly  Pro Ile Trp Ile Val  Thr Arg Gly Ala Gln  Arg Val Ala 
    2735                 2740                 2745             


Asp Thr  Asp Thr Val Ala Pro  His Gln Ser Cys Leu  Trp Gly Phe 
    2750                 2755                 2760             


Gly Arg  Ala Ala Ser Leu Glu  Leu Pro His Val Trp  Gly Gly Leu 
    2765                 2770                 2775             


Ala Asp  Leu Ser Glu Gly Gly  Asp Asn Ala Ala Asp  Glu Trp Ser 
    2780                 2785                 2790             


Ala Leu  Val Asp Arg Ile Ala  Ala Pro His Gly Ser  Ala Val Arg 
    2795                 2800                 2805             


Glu Asp  Gln Leu Ala Leu Arg  Asp Arg Ala Val Tyr  Thr Pro Arg 
    2810                 2815                 2820             


Leu Ala  Arg Arg Ser Ala Pro  Pro Ser Gly Thr Pro  Leu His Leu 
    2825                 2830                 2835             


Arg Gly  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2840                 2845                 2850             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2855                 2860                 2865             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2870                 2875                 2880             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2885                 2890                 2895             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2900                 2905                 2910             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2915                 2920                 2925             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2930                 2935                 2940             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2945                 2950                 2955             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2960                 2965                 2970             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2975                 2980                 2985             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2990                 2995                 3000             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    3005                 3010                 3015             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    3020                 3025                 3030             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    3035                 3040                 3045             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    3050                 3055                 3060             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    3065                 3070                 3075             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    3080                 3085                 3090             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    3095                 3100                 3105             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    3110                 3115                 3120             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    3125                 3130                 3135             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    3140                 3145                 3150             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    3155                 3160                 3165             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Thr 
    3170                 3175                 3180             


Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys Gln Gly  Asp Gly Glu 
    3185                 3190                 3195             


Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly Pro Pro  Val Glu His 
    3200                 3205                 3210             


Arg Ala  Arg Leu Val Cys Phe  Pro His Ala Gly Ala  Ala Ala Asp 
    3215                 3220                 3225             


Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala Pro Glu  Ile Asp Val 
    3230                 3235                 3240             


His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp Arg Arg  Asp Glu Glu 
    3245                 3250                 3255             


Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp Glu Val  Ala Ala Val 
    3260                 3265                 3270             


Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe Ala Leu  Phe Gly His 
    3275                 3280                 3285             


Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr Ala Arg  Arg Leu Glu 
    3290                 3295                 3300             


Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu Phe Val  Ser Gly Gln 
    3305                 3310                 3315             


Thr Ala  Pro Arg Val His Glu  Arg Arg Thr Asp Leu  Pro Gly Asp 
    3320                 3325                 3330             


Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu Gly Thr  Ser Glu Ala 
    3335                 3340                 3345             


Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met Ser Leu  Pro Val Leu 
    3350                 3355                 3360             


Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr Ala Trp  Ala Asp Gly 
    3365                 3370                 3375             


Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu Cys Gly  Asp Ala Asp 
    3380                 3385                 3390             


Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg Trp Leu  Gln His Ser 
    3395                 3400                 3405             


Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro Gly Gly  His Phe Tyr 
    3410                 3415                 3420             


Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly Ala Val  Arg Arg Asp 
    3425                 3430                 3435             


Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3440                 3445     


<210>  134
<211>  11994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-MalH

<400>  134
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg ccattcagac aggcgcatca     1860

ctgtcaattc cggcaatcca atcgcgcagc aaccgtgacc agcacttgcc cttagtagct     1920

gcgcaacctg gaatatggat ggccgagaag ttatctgaac taccatcagc gtggagcgta     1980

gcgcattacg tggagctcac tggtgaggtt gactcgcctc ttttggccag ggcggtagtg     2040

gctggccttg cacaagctga caccttaaga atgcgtttca cagaggataa tggggaagtt     2100

tggcaatggg tagacgatgc gttaacattt gagttaccgg aaatcataga cctgcgcact     2160

aacatagacc ctcacgggac agctcaggcc ttgatgcaag cggacctgca acaggaccta     2220

cgtgtggatt cggggaagcc tctggtcttc catcagctaa ttcaagtagc ggacaatcgc     2280

tggtactggt atcaaaggta ccaccacttg cttgtggacg ggttcagttt tccagcgata     2340

accaggcaaa tagccaacat ttattgcact tggttgcgag gagagcctac gcccgcatcc     2400

cccttcacgc cattcgcaga cgttgttgag gaataccaac agtatcgcga gagcgaagcg     2460

tggcaacgcg atgcggcatt ctgggcggag caacgacggc aactaccgcc tcccgcatcc     2520

ctatcacctg ccccgctccc cggccggtcc gcgtcagccg acattctacg gctaaagctg     2580

gagttcacag atggtgaatt tcgacagctt gctacacaac tcagcggggt acaaaggaca     2640

gacctagcgc tcgctctggc tgcattatgg ctaggacgac tttgcaatcg aatggactac     2700

gcggcgggtt tcatatttat gcgccggctc ggcagcgcag cgttgaccgc aacgggtcca     2760

gttttaaatg ttcttccttt gggaatccac ataggcaacc caagcttctc tgagcttctc     2820

accagggttc gcgaggtcgc cttaggcgcg tatgcacacc aacatattcc ttttgagatg     2880

ttagtagagg cactgcaacc agagcgaaac cttagccata ctcctctctt ccaagtgatg     2940

tttgtccttc agaatgcgcc cgcgtcccaa ttagagttaa ccgggatcac cgcaaaccca     3000

attaaggtta aatcaactac cacgaagttc gacctaactt taatcatgca aaacacagct     3060

agcggattag taggtgtttg ggagtacaac acggatttat tcgacgcgtc aacgattgag     3120

cgaatgacag ggcactttgt aaccctcctc gagggcgtta tcgccaatcc acaacagccg     3180

atctctcaac ttcctatttt aactacagtg gagcaacagc aacttttagt cgagtggaat     3240

aacacgcaaa ccgactaccc cgctgataag tgtatacatc aattattcga ggaacaggtc     3300

gagcgcacac cagacgccgt tgctgtcgtc tttgggaatc agcaactcag ctatcgagag     3360

atgcgcgaac aagtggttgc actcgccaat ttattacgtg agcggggagt caagccagga     3420

gactccgttg ccgtggcctt accacgctct gttttcttaa cccttgcact acacgcgatt     3480

gtcgaggcag gtgccgcctg gctacctctt gacacaggat atcctgacga tagattaaaa     3540

atgatgctcg aggatgcacg gccttccctt ctgatcacaa cagacgatca attaccccgc     3600

ttcagtgacg tacctaatct gacctcactc tgttacaacg ctcccttgac gcctcaaggg     3660

agcgcccctt tacagctgtc tcaacctcac catactgcat atatcatctt tacaagtggt     3720

tctacgggac gccccaaggg agtaatggtt ggtcagactg cgattgtaaa tcgtctgttg     3780

tggatgcaaa accactaccc tttgacgggg gaggacgttg tagcccaaaa gactccttgc     3840

tcgttcgatg tctcagtctg ggagttcttt tggccattta tagcaggggc caaattagtt     3900

atggcggagc cggaagccca ccgagaccca cttgcgatgc agcaattctt tgctgagtat     3960

ggtgtcacca ctacacattt cgtcccatcg atgttagcgg ccttcgtggc ttctcttact     4020

ccacaaacgg ctaggcaatc ttgtgccaca ctaaagcaag tcttctgctc cggcgaggca     4080

ttacctgcag acttgtgccg ggaatggcag caactcacag gagctccatt gcacaatcta     4140

tacggaccga ccgaggccgc agtagacgta tcttggtatc ctgcgtttgg cgaggagtta     4200

gcgcaagtaa gaggttcgtc agtaccaata ggataccccg tatggaacac ggggcttcgg     4260

atactggacg cgatgatgca tccggtccca ccaggagtcg cgggcgattt atacctgact     4320

gggatacagc tggcccaagg ttacctaggg agacctgacc ttacggcgtc gaggttcata     4380

gcggatccgt ttgctccggg tgagcgcatg taccgtacgg gcgacgtcgc gcgatggcta     4440

gataatggcg ccgtagagta tcttggtaga tcagacgatc agttaaagat acggggacaa     4500

cgaatagagc ttggggaaat agaccgggta atgcaggctt tgccagatgt cgagcaagcg     4560

gtggcttcgt gtgctattgc gcgggaggac atacctggga acaaacacct tgtagcgtac     4620

atagttcctc aagaggagca aacatgcact gagcgatcga ggtccacact tacagtttcg     4680

ttcgtccgga gtttccttaa ggagaaactc cccgaatata tggtaccgag cgcaatagtg     4740

attctagacg ctctccccct gactcctaat ggaaagctag accggcgggc gttacccgcc     4800

cctgacctgc actcacaact tgagacaatt attgctgcgg ctttctcgag cctgctcggg     4860

tgcgacgtac aagacgcgga tgctgacttt ttcgcgctag gtggccattc gctgcttgcc     4920

atgaagctag ccgctcagct ttcccgacaa gtagcgcggc aggtgacacc aggccaagtt     4980

atggtagctt cgactgtcgc aaagctcgca acgatcatag acgcggagtt agataaatac     5040

gtcgctccaa ggaacccgat acctggaatt ggggcgctag ttcccgctcc cgtggtaatc     5100

gcagcaggcc gtacggagga accaattgcc atagtatcca tggcttgccg gttacccggt     5160

ggtgtgaata ccccacagag actatgggaa ttattacgtg aagggggaga aaccctcagt     5220

ggcttcccta ccgaccgagg gtgggacctc gcgaggttgc atcacccaga cccagacaac     5280

cccggtacgt catacgttga taaaggggga ttcctggacg atgcggcagg gtttgacgca     5340

gaatttttcg gtgtgagccc cagagaagca gcggctatgg acccgcagca gagattactc     5400

ctcgaaacca gctgggagtt agtcgagaat gcagggattg atccacatag cctaaggggg     5460

accgccactg gtgtcttcct cggcgttgcc aagtttgggt atggcgagga tacggcagct     5520

gccgaagacg tcgaggggta ctctgtcact ggtgtagccc cggcagtggc gtcgggcaga     5580

attagttaca cgatggggtt ggaagggccg tctatttcgg ttgataccgc ctgttcctcc     5640

agtctggttg cactccacct tgcagtcgag tcgctccgga aaggagaaag cagtatggcc     5700

gtggtcgggg gagcggcggt gatggccaca ccgggtgtgt ttgtggattt ttcccgacag     5760

agagccttgg ccgcggatgg gcgttcaaag gcgttcggag caggtgcaga cgggtttgga     5820

tttagcgaag gtgtgacact ggttctccta gaaagattaa gtgaagcccg gcgtaacggc     5880

catgaggtgc tggcagttgt tagaggttcc gcattaaacc aggacggggc ttcgaacggg     5940

ctgagcgccc cctcgggccc ggcacagaga agagtgatac gccaagcact cgaatcgtgt     6000

ggcctagaac caggtgacgt tgacgcggtg gaagcgcacg ggacaggaac tgcgttaggg     6060

gacccgatag aagcaaacgc cttgctggac acttatggta gagatcgtga tgcggatcga     6120

cccctctggt taggaagtgt taagtcaaat ataggacaca ctcaggcagc ggcgggagta     6180

actgggctgc tcaaagtagt cctagcctta cgcaatgggg aactacccgc caccctacat     6240

gtcgaggaac cgacaccgca tgtggattgg tcgagcgggg gagttgctct cttggcgggt     6300

aatcagccgt ggcgaagagg tgaacgaacc cgtagagccg ccgtgtccgc attcgggatc     6360

agtggtacga acgcgcacgt gattgtggaa gaagctccac aagaggtgag accagcgccc     6420

ggtcaaggac tctcgcccgc ggtgtcaacc ttggtagtgg cgggtaaaac tatgcagcgt     6480

gtttcggcaa ccgccggtat gctcgcagat tggatggaag gcccaggtgc agatgtggcg     6540

ctggcggacg tggcgcacac gttaaatcat caccgttcac ggcaaccaaa gttcggtacg     6600

gtggtggcca gggaccggac acaggcaatc gccggactaa gagcgctggc ggcgggtcag     6660

cacgccccag gggttgttaa ccctgctgaa ggaagtccag gtccagggac ggtgttcgtg     6720

tttcctggcc aggggtccca gcgtgcaggc atgggggagg agttggctgc ggctttcccc     6780

gtgtttgcca gaatccacca gcaagtgtgg gatttactcg atgttcctga tctcgacgtt     6840

aacgaaacgg ggtacgcaca accagcactc ttcgcactcc aagtggcgct gtttgggctc     6900

ctcgaatcat ggggagtacg gccggatgcc gtggtcgggc atagtgtagg ggaattagcg     6960

gcagggtacg tttccgggct ttggagtctt gaggatgctt gcacgctcgt gtcggcgaga     7020

gcccgtctaa tgcaagcctt accggcaggt ggtgttatgg cggcagttcc agtgtccgaa     7080

gacgaagcac gggctgtgtt gggggaagga gtcgaaatag ctgcggtcaa cggtccgtcg     7140

agcgtggttc taagcggtga tgaagcagca gtgctccagg ccgcggaagg gttaggcaag     7200

tggacgcgat taccgacctc gcatgcattc cattctgctc gtatggaacc aatgctggaa     7260

gagtttagag cagtggcgga aggtctaaca tacaggactc cccaggtggc aatggccgcc     7320

ggagaccagg ttatgaccgc tgaatactgg gtgcgtcagg ttagggatac agttcgtttt     7380

ggcgagcaag ttgcctcgtt cgaggatgct gtattcgtgg aattgggagc agatcgctct     7440

cttgcacggc tagtcgatgg tatcgcgatg ttgcacgggg atcatgaggc acaggctggt     7500

atgcggagag aacaaccctt gcccttaggt ttacgaagat tgctaaccga cctgcataac     7560

gctggtgctg ccgtcgattt tagtgttttg tgcccacaag gtcgtctggt tgacgcaccg     7620

ttaccagcct ggtcacaccg gtttctcttc tatgaccggg aaggagtgga caatagatca     7680

ccagggggaa gcacagtggc ggtccacccg cttttactag ccgcggtgga tgtgccgggc     7740

cacggtggag cggttttcac gggtagactc tcgactgacg agcaaccgtg gttagcggag     7800

cacgttgtcg ggggaagaac cctagttcct ggttctgttt tagtcgatct agccttagcg     7860

gcaggcgaag acgtagggct accggtgtta gaagaattag tattgcagag gccgctggtg     7920

cttgccggcg cgggagcact cctacggatg tcggtcgggg caccagacga gagcggtaga     7980

agaactatcg atgttcacgc agctgaagac gtcgccgatt tagcagatgc ccaatggtcc     8040

cagcacgcca ccgggacttt agcccaaggg gtagcggcgg ggcccaggga cacagagcaa     8100

tggcccccag aggatgccgt ccggattcca ttagacgacc attatgatgg tctcgcggaa     8160

cagggttatg agtacggtcc gtcgtttcag gcgctagtgg cctacgtggc ggaggatgcg     8220

actgcgacaa tgttagcgga agtcgcgctt ccgggcagca ttagatcgca acaaggtcta     8280

tacgccatcc atcccgcact gctggacgct tgttttcaat ctgtcggagc ccacccagac     8340

agtcaatccg tcgggtcagg tctactcgta cccctcggtg ttcggagagt tcgtgcgtac     8400

gcacccgtaa ggaccgcccg ttattgttac acccgcgtca cgaaagttga actagctggg     8460

gttgaggccg acatcgacgt tctggatgct cacggcacag tgcttctagc cgtgtgcggt     8520

cttcgtatcg ggaccggagt gagcgagagg gacaaacaca acagagttct caatgagcgc     8580

ctactcacca tcgaatggca tcagcgtgaa ctaccagaaa tggacccctc gggtgccggg     8640

aagtggctcc taatctcgga ctgtgcagca tccgatgtca ccgctacacg actggctgat     8700

gccttccggg agcacagcgc tgcgtgcact accatgcggt ggccacttca cgatgatcaa     8760

ctagcagccg ccgaccaact ccgggaccag gtgggttcag atgagttttc tggcgtggta     8820

gtactaacag ggccaaacac agggacccct catcagggtt ccgcagaccg tggcgccgag     8880

tacgttaggc ggttagttgg aatcgctcgt gaacttagcg atcttcccgg agcggttccc     8940

cgtatgtatg tcgtcacaag gggagcgcag agagtccttg ccgatgattg tgttaattta     9000

gaacagggag ggctcagagg tctgctgagg accatcggtg ctgagcaccc acatctccgc     9060

gccacccaaa ttgatgttga tgagcagaca ggagtagagc agctggcgcg acaactccta     9120

gctacatcgg aggaagacga gacagcctgg agggacaacg aatggtacgt tgcgaggtta     9180

tgccccacac ccctgaggcc acaggaacgt aggacaatag tggcggacca tcaacagtct     9240

ggtatgcggt tacaaatacg tacgcccggt gcaatcgata gtgtggcctt tgaacccgca     9300

cccgatgtag agcaaccctt acgggcgggt gaagttcggg ttgacgttag agcaaccggt     9360

gttaatttcc gtgacgttct actcgctctc gggatgtatc cccagaaagc tgacatgggg     9420

acagaagcag ctggtgttgt aacagcagtg ggacctgatg tcgatgcgtt tgcgcctggt     9480

gatagagttc tagggctatt ccaaggggca tttgctccaa ttgcggtgac tgaccatcgt     9540

ttactggcac gggtgccaga cgggtggtca gatgccgatg cggcggcggt gccaatagct     9600

tacacgacag cacattatgc gctgcacgac ctggcggggt tgcgggcggg gcaatctgtc     9660

ctgatacacg cggcagcggg tggtgttggt atggccgctg ttgcactggc acggagggcc     9720

ggcgcagaag ttctggctac cgcaggacct gcaaaacacg gtacgctacg ggcattaggg     9780

ctagatgatg aacacatcgc ttcgagtcgg gagaccgggt tcgcgcgtaa gttccgagag     9840

cggactgggg gacgaggagt ggacgtcgtt ctaaacagct tgaccggcga actattagac     9900

gagtccgcgg atctcctcgc ggaggacgga gtcttcgtgg aaatgggaaa gactgatctg     9960

cgcgatgcag gggactttcg tgggcgctac gccccgtttg atctagggga agcaggcgat    10020

gacaggctcg gggaaattct acgtgaggtg gtgggactgc tcggtgcagg ggaactcgac    10080

cgactccctg ttagcgcgtg ggaattgggg ataccccaga cggggaagtc gttagtgacg    10140

ctgccacccg aacaagcgca agttttcaga ccagacggca ctgtattgat caccggggga    10200

acgggaacgt taggtcggct gctggcccgt catctggtta cagagcacgg ggtgcgtcac    10260

ctgctgctag tgtcgaggag aggagcagat gcccctggat cggacgagct gagggccgaa    10320

atcgaggatc tcggagcatc agcggaaatt gcagcatgtg atacagccga tcgagacgct    10380

ctcagcgcgt tgctagatgg actgccgagg ccactgaccg gagtagttca cgccgcggga    10440

gtcctcgctg acggtctggt tacatccatc gacgagcccg cagtcgaaca agttctccgt    10500

gcaaaagttg atgcggcctg gaacctgcac gagctaactg cgaacaccgg tctcagcttt    10560

ttcgtgctgt tctcgtcagc cgcaagtgtg ttagcggggc cggggcaggg agtatatgcg    10620

gcagcgaacg aatctttaaa cgctctggcc gctctgcgta ggactagggg tttacccgca    10680

aaagcattgg gatggggatt atgggcgata gggcgtgcaa tagcatttgc cgagcagacc    10740

ggtgacgcaa tcgccccgga ggaaggcgcg tacgccttcg agacactact cagacataac    10800

agggcgtact cgggttacgc tcccgtgata gggtcaccat ggctgactgc gttcgcccaa    10860

cattcgccct ttgcggagaa gttccagtcc ctggggcaaa atagatccgg gacgtctaag    10920

tttctggcag aattagtcga tctgccaaga gaagaatggc cagatcggtt acgtcgtcta    10980

ttagaactgg tgaggtctca tgctgccgca gtttcggggt atggatcggc agaccaatta    11040

ccagaaagaa aagcattcaa agacctcgga ttcgattcac tggcagcagt cgaactaaga    11100

aatcgtctag ggaccgcgac aggcgtccgg ctgcccagta ctctggtgtt cgaccaccca    11160

accccacttg cggttgcgga acatctacgt gatcgtctaa catccgggga agataaccct    11220

atccccctat gtcaaggcga tggggaggag atgagcacat ggctacgtcg ttttggaccc    11280

ccagtcgaac atcgggccag gctagtgtgt ttcccccacg caggcgcagc ggcggattca    11340

tacttagacc tagcaagagc gttagcacca gagatcgatg ttcatgctgt tcaatacccc    11400

ggcaggcaag acagaaggga cgaggagcca ttaggaaccg caggtgaaat tgcagatgaa    11460

gtggcagcgg tgctacgtgc gtcgggaggg gatgggcctt ttgcactttt cggccacagt    11520

atgggcgccc tcatcgcgta cgagacagca aggcgattag agagggaacc gggaggggga    11580

cccttacgtt tattcgtgag cggacaaaca gcgccacgtg tccatgaacg aagaactgat    11640

ctgcccggtg acgatggact cgtggacgag cttaggcgac ttggcacctc cgaggcagcg    11700

ctcgcagacg aagccctgct ggctatgtct ctcccggtgc tcagggcgga ttatagggtg    11760

ttaagatcct acgcttgggc ggatggtccc ccactacgcg ccggtataac tgccctctgc    11820

ggtgatgcag acccactaac tgcaacaggg gatgcggaac gctggttaca acattccgtg    11880

attccgggtc ggacacggac atttcccggt gggcattttt atttagggga acaagtgacc    11940

gaggtggcag gggctgtccg tagagattta ctgagagcag ggttagcggg ttga          11994


<210>  135
<211>  3997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-MalH

<400>  135

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Ala Ile Gln Thr Gly Ala Ser Leu Ser Ile Pro 
    610                 615                 620                 


Ala Ile Gln Ser Arg Ser Asn Arg Asp Gln His Leu Pro Leu Val Ala 
625                 630                 635                 640 


Ala Gln Pro Gly Ile Trp Met Ala Glu Lys Leu Ser Glu Leu Pro Ser 
                645                 650                 655     


Ala Trp Ser Val Ala His Tyr Val Glu Leu Thr Gly Glu Val Asp Ser 
            660                 665                 670         


Pro Leu Leu Ala Arg Ala Val Val Ala Gly Leu Ala Gln Ala Asp Thr 
        675                 680                 685             


Leu Arg Met Arg Phe Thr Glu Asp Asn Gly Glu Val Trp Gln Trp Val 
    690                 695                 700                 


Asp Asp Ala Leu Thr Phe Glu Leu Pro Glu Ile Ile Asp Leu Arg Thr 
705                 710                 715                 720 


Asn Ile Asp Pro His Gly Thr Ala Gln Ala Leu Met Gln Ala Asp Leu 
                725                 730                 735     


Gln Gln Asp Leu Arg Val Asp Ser Gly Lys Pro Leu Val Phe His Gln 
            740                 745                 750         


Leu Ile Gln Val Ala Asp Asn Arg Trp Tyr Trp Tyr Gln Arg Tyr His 
        755                 760                 765             


His Leu Leu Val Asp Gly Phe Ser Phe Pro Ala Ile Thr Arg Gln Ile 
    770                 775                 780                 


Ala Asn Ile Tyr Cys Thr Trp Leu Arg Gly Glu Pro Thr Pro Ala Ser 
785                 790                 795                 800 


Pro Phe Thr Pro Phe Ala Asp Val Val Glu Glu Tyr Gln Gln Tyr Arg 
                805                 810                 815     


Glu Ser Glu Ala Trp Gln Arg Asp Ala Ala Phe Trp Ala Glu Gln Arg 
            820                 825                 830         


Arg Gln Leu Pro Pro Pro Ala Ser Leu Ser Pro Ala Pro Leu Pro Gly 
        835                 840                 845             


Arg Ser Ala Ser Ala Asp Ile Leu Arg Leu Lys Leu Glu Phe Thr Asp 
    850                 855                 860                 


Gly Glu Phe Arg Gln Leu Ala Thr Gln Leu Ser Gly Val Gln Arg Thr 
865                 870                 875                 880 


Asp Leu Ala Leu Ala Leu Ala Ala Leu Trp Leu Gly Arg Leu Cys Asn 
                885                 890                 895     


Arg Met Asp Tyr Ala Ala Gly Phe Ile Phe Met Arg Arg Leu Gly Ser 
            900                 905                 910         


Ala Ala Leu Thr Ala Thr Gly Pro Val Leu Asn Val Leu Pro Leu Gly 
        915                 920                 925             


Ile His Ile Gly Asn Pro Ser Phe Ser Glu Leu Leu Thr Arg Val Arg 
    930                 935                 940                 


Glu Val Ala Leu Gly Ala Tyr Ala His Gln His Ile Pro Phe Glu Met 
945                 950                 955                 960 


Leu Val Glu Ala Leu Gln Pro Glu Arg Asn Leu Ser His Thr Pro Leu 
                965                 970                 975     


Phe Gln Val Met Phe Val Leu Gln Asn Ala Pro Ala Ser Gln Leu Glu 
            980                 985                 990         


Leu Thr Gly Ile Thr Ala Asn Pro  Ile Lys Val Lys Ser  Thr Thr Thr 
        995                 1000                 1005             


Lys Phe  Asp Leu Thr Leu Ile  Met Gln Asn Thr Ala  Ser Gly Leu 
    1010                 1015                 1020             


Val Gly  Val Trp Glu Tyr Asn  Thr Asp Leu Phe Asp  Ala Ser Thr 
    1025                 1030                 1035             


Ile Glu  Arg Met Thr Gly His  Phe Val Thr Leu Leu  Glu Gly Val 
    1040                 1045                 1050             


Ile Ala  Asn Pro Gln Gln Pro  Ile Ser Gln Leu Pro  Ile Leu Thr 
    1055                 1060                 1065             


Thr Val  Glu Gln Gln Gln Leu  Leu Val Glu Trp Asn  Asn Thr Gln 
    1070                 1075                 1080             


Thr Asp  Tyr Pro Ala Asp Lys  Cys Ile His Gln Leu  Phe Glu Glu 
    1085                 1090                 1095             


Gln Val  Glu Arg Thr Pro Asp  Ala Val Ala Val Val  Phe Gly Asn 
    1100                 1105                 1110             


Gln Gln  Leu Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    1115                 1120                 1125             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    1130                 1135                 1140             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    1145                 1150                 1155             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    1160                 1165                 1170             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    1175                 1180                 1185             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    1190                 1195                 1200             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    1205                 1210                 1215             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    1220                 1225                 1230             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    1235                 1240                 1245             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    1250                 1255                 1260             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    1265                 1270                 1275             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    1280                 1285                 1290             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    1295                 1300                 1305             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    1310                 1315                 1320             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    1325                 1330                 1335             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    1340                 1345                 1350             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    1355                 1360                 1365             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    1370                 1375                 1380             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    1385                 1390                 1395             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    1400                 1405                 1410             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    1415                 1420                 1425             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    1430                 1435                 1440             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    1445                 1450                 1455             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    1460                 1465                 1470             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    1475                 1480                 1485             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    1490                 1495                 1500             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    1505                 1510                 1515             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    1520                 1525                 1530             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    1535                 1540                 1545             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    1550                 1555                 1560             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    1565                 1570                 1575             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    1580                 1585                 1590             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Glu 
    1595                 1600                 1605             


Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val 
    1610                 1615                 1620             


Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu 
    1625                 1630                 1635             


Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg 
    1640                 1645                 1650             


Gln Val  Thr Pro Gly Gln Val  Met Val Ala Ser Thr  Val Ala Lys 
    1655                 1660                 1665             


Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Asp Lys Tyr  Val Ala Pro 
    1670                 1675                 1680             


Arg Asn  Pro Ile Pro Gly Ile  Gly Ala Leu Val Pro  Ala Pro Val 
    1685                 1690                 1695             


Val Ile  Ala Ala Gly Arg Thr  Glu Glu Pro Ile Ala  Ile Val Ser 
    1700                 1705                 1710             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Asn Thr Pro  Gln Arg Leu 
    1715                 1720                 1725             


Trp Glu  Leu Leu Arg Glu Gly  Gly Glu Thr Leu Ser  Gly Phe Pro 
    1730                 1735                 1740             


Thr Asp  Arg Gly Trp Asp Leu  Ala Arg Leu His His  Pro Asp Pro 
    1745                 1750                 1755             


Asp Asn  Pro Gly Thr Ser Tyr  Val Asp Lys Gly Gly  Phe Leu Asp 
    1760                 1765                 1770             


Asp Ala  Ala Gly Phe Asp Ala  Glu Phe Phe Gly Val  Ser Pro Arg 
    1775                 1780                 1785             


Glu Ala  Ala Ala Met Asp Pro  Gln Gln Arg Leu Leu  Leu Glu Thr 
    1790                 1795                 1800             


Ser Trp  Glu Leu Val Glu Asn  Ala Gly Ile Asp Pro  His Ser Leu 
    1805                 1810                 1815             


Arg Gly  Thr Ala Thr Gly Val  Phe Leu Gly Val Ala  Lys Phe Gly 
    1820                 1825                 1830             


Tyr Gly  Glu Asp Thr Ala Ala  Ala Glu Asp Val Glu  Gly Tyr Ser 
    1835                 1840                 1845             


Val Thr  Gly Val Ala Pro Ala  Val Ala Ser Gly Arg  Ile Ser Tyr 
    1850                 1855                 1860             


Thr Met  Gly Leu Glu Gly Pro  Ser Ile Ser Val Asp  Thr Ala Cys 
    1865                 1870                 1875             


Ser Ser  Ser Leu Val Ala Leu  His Leu Ala Val Glu  Ser Leu Arg 
    1880                 1885                 1890             


Lys Gly  Glu Ser Ser Met Ala  Val Val Gly Gly Ala  Ala Val Met 
    1895                 1900                 1905             


Ala Thr  Pro Gly Val Phe Val  Asp Phe Ser Arg Gln  Arg Ala Leu 
    1910                 1915                 1920             


Ala Ala  Asp Gly Arg Ser Lys  Ala Phe Gly Ala Gly  Ala Asp Gly 
    1925                 1930                 1935             


Phe Gly  Phe Ser Glu Gly Val  Thr Leu Val Leu Leu  Glu Arg Leu 
    1940                 1945                 1950             


Ser Glu  Ala Arg Arg Asn Gly  His Glu Val Leu Ala  Val Val Arg 
    1955                 1960                 1965             


Gly Ser  Ala Leu Asn Gln Asp  Gly Ala Ser Asn Gly  Leu Ser Ala 
    1970                 1975                 1980             


Pro Ser  Gly Pro Ala Gln Arg  Arg Val Ile Arg Gln  Ala Leu Glu 
    1985                 1990                 1995             


Ser Cys  Gly Leu Glu Pro Gly  Asp Val Asp Ala Val  Glu Ala His 
    2000                 2005                 2010             


Gly Thr  Gly Thr Ala Leu Gly  Asp Pro Ile Glu Ala  Asn Ala Leu 
    2015                 2020                 2025             


Leu Asp  Thr Tyr Gly Arg Asp  Arg Asp Ala Asp Arg  Pro Leu Trp 
    2030                 2035                 2040             


Leu Gly  Ser Val Lys Ser Asn  Ile Gly His Thr Gln  Ala Ala Ala 
    2045                 2050                 2055             


Gly Val  Thr Gly Leu Leu Lys  Val Val Leu Ala Leu  Arg Asn Gly 
    2060                 2065                 2070             


Glu Leu  Pro Ala Thr Leu His  Val Glu Glu Pro Thr  Pro His Val 
    2075                 2080                 2085             


Asp Trp  Ser Ser Gly Gly Val  Ala Leu Leu Ala Gly  Asn Gln Pro 
    2090                 2095                 2100             


Trp Arg  Arg Gly Glu Arg Thr  Arg Arg Ala Ala Val  Ser Ala Phe 
    2105                 2110                 2115             


Gly Ile  Ser Gly Thr Asn Ala  His Val Ile Val Glu  Glu Ala Pro 
    2120                 2125                 2130             


Gln Glu  Val Arg Pro Ala Pro  Gly Gln Gly Leu Ser  Pro Ala Val 
    2135                 2140                 2145             


Ser Thr  Leu Val Val Ala Gly  Lys Thr Met Gln Arg  Val Ser Ala 
    2150                 2155                 2160             


Thr Ala  Gly Met Leu Ala Asp  Trp Met Glu Gly Pro  Gly Ala Asp 
    2165                 2170                 2175             


Val Ala  Leu Ala Asp Val Ala  His Thr Leu Asn His  His Arg Ser 
    2180                 2185                 2190             


Arg Gln  Pro Lys Phe Gly Thr  Val Val Ala Arg Asp  Arg Thr Gln 
    2195                 2200                 2205             


Ala Ile  Ala Gly Leu Arg Ala  Leu Ala Ala Gly Gln  His Ala Pro 
    2210                 2215                 2220             


Gly Val  Val Asn Pro Ala Glu  Gly Ser Pro Gly Pro  Gly Thr Val 
    2225                 2230                 2235             


Phe Val  Phe Pro Gly Gln Gly  Ser Gln Arg Ala Gly  Met Gly Glu 
    2240                 2245                 2250             


Glu Leu  Ala Ala Ala Phe Pro  Val Phe Ala Arg Ile  His Gln Gln 
    2255                 2260                 2265             


Val Trp  Asp Leu Leu Asp Val  Pro Asp Leu Asp Val  Asn Glu Thr 
    2270                 2275                 2280             


Gly Tyr  Ala Gln Pro Ala Leu  Phe Ala Leu Gln Val  Ala Leu Phe 
    2285                 2290                 2295             


Gly Leu  Leu Glu Ser Trp Gly  Val Arg Pro Asp Ala  Val Val Gly 
    2300                 2305                 2310             


His Ser  Val Gly Glu Leu Ala  Ala Gly Tyr Val Ser  Gly Leu Trp 
    2315                 2320                 2325             


Ser Leu  Glu Asp Ala Cys Thr  Leu Val Ser Ala Arg  Ala Arg Leu 
    2330                 2335                 2340             


Met Gln  Ala Leu Pro Ala Gly  Gly Val Met Ala Ala  Val Pro Val 
    2345                 2350                 2355             


Ser Glu  Asp Glu Ala Arg Ala  Val Leu Gly Glu Gly  Val Glu Ile 
    2360                 2365                 2370             


Ala Ala  Val Asn Gly Pro Ser  Ser Val Val Leu Ser  Gly Asp Glu 
    2375                 2380                 2385             


Ala Ala  Val Leu Gln Ala Ala  Glu Gly Leu Gly Lys  Trp Thr Arg 
    2390                 2395                 2400             


Leu Pro  Thr Ser His Ala Phe  His Ser Ala Arg Met  Glu Pro Met 
    2405                 2410                 2415             


Leu Glu  Glu Phe Arg Ala Val  Ala Glu Gly Leu Thr  Tyr Arg Thr 
    2420                 2425                 2430             


Pro Gln  Val Ala Met Ala Ala  Gly Asp Gln Val Met  Thr Ala Glu 
    2435                 2440                 2445             


Tyr Trp  Val Arg Gln Val Arg  Asp Thr Val Arg Phe  Gly Glu Gln 
    2450                 2455                 2460             


Val Ala  Ser Phe Glu Asp Ala  Val Phe Val Glu Leu  Gly Ala Asp 
    2465                 2470                 2475             


Arg Ser  Leu Ala Arg Leu Val  Asp Gly Ile Ala Met  Leu His Gly 
    2480                 2485                 2490             


Asp His  Glu Ala Gln Ala Gly  Met Arg Arg Glu Gln  Pro Leu Pro 
    2495                 2500                 2505             


Leu Gly  Leu Arg Arg Leu Leu  Thr Asp Leu His Asn  Ala Gly Ala 
    2510                 2515                 2520             


Ala Val  Asp Phe Ser Val Leu  Cys Pro Gln Gly Arg  Leu Val Asp 
    2525                 2530                 2535             


Ala Pro  Leu Pro Ala Trp Ser  His Arg Phe Leu Phe  Tyr Asp Arg 
    2540                 2545                 2550             


Glu Gly  Val Asp Asn Arg Ser  Pro Gly Gly Ser Thr  Val Ala Val 
    2555                 2560                 2565             


His Pro  Leu Leu Leu Ala Ala  Val Asp Val Pro Gly  His Gly Gly 
    2570                 2575                 2580             


Ala Val  Phe Thr Gly Arg Leu  Ser Thr Asp Glu Gln  Pro Trp Leu 
    2585                 2590                 2595             


Ala Glu  His Val Val Gly Gly  Arg Thr Leu Val Pro  Gly Ser Val 
    2600                 2605                 2610             


Leu Val  Asp Leu Ala Leu Ala  Ala Gly Glu Asp Val  Gly Leu Pro 
    2615                 2620                 2625             


Val Leu  Glu Glu Leu Val Leu  Gln Arg Pro Leu Val  Leu Ala Gly 
    2630                 2635                 2640             


Ala Gly  Ala Leu Leu Arg Met  Ser Val Gly Ala Pro  Asp Glu Ser 
    2645                 2650                 2655             


Gly Arg  Arg Thr Ile Asp Val  His Ala Ala Glu Asp  Val Ala Asp 
    2660                 2665                 2670             


Leu Ala  Asp Ala Gln Trp Ser  Gln His Ala Thr Gly  Thr Leu Ala 
    2675                 2680                 2685             


Gln Gly  Val Ala Ala Gly Pro  Arg Asp Thr Glu Gln  Trp Pro Pro 
    2690                 2695                 2700             


Glu Asp  Ala Val Arg Ile Pro  Leu Asp Asp His Tyr  Asp Gly Leu 
    2705                 2710                 2715             


Ala Glu  Gln Gly Tyr Glu Tyr  Gly Pro Ser Phe Gln  Ala Leu Val 
    2720                 2725                 2730             


Ala Tyr  Val Ala Glu Asp Ala  Thr Ala Thr Met Leu  Ala Glu Val 
    2735                 2740                 2745             


Ala Leu  Pro Gly Ser Ile Arg  Ser Gln Gln Gly Leu  Tyr Ala Ile 
    2750                 2755                 2760             


His Pro  Ala Leu Leu Asp Ala  Cys Phe Gln Ser Val  Gly Ala His 
    2765                 2770                 2775             


Pro Asp  Ser Gln Ser Val Gly  Ser Gly Leu Leu Val  Pro Leu Gly 
    2780                 2785                 2790             


Val Arg  Arg Val Arg Ala Tyr  Ala Pro Val Arg Thr  Ala Arg Tyr 
    2795                 2800                 2805             


Cys Tyr  Thr Arg Val Thr Lys  Val Glu Leu Ala Gly  Val Glu Ala 
    2810                 2815                 2820             


Asp Ile  Asp Val Leu Asp Ala  His Gly Thr Val Leu  Leu Ala Val 
    2825                 2830                 2835             


Cys Gly  Leu Arg Ile Gly Thr  Gly Val Ser Glu Arg  Asp Lys His 
    2840                 2845                 2850             


Asn Arg  Val Leu Asn Glu Arg  Leu Leu Thr Ile Glu  Trp His Gln 
    2855                 2860                 2865             


Arg Glu  Leu Pro Glu Met Asp  Pro Ser Gly Ala Gly  Lys Trp Leu 
    2870                 2875                 2880             


Leu Ile  Ser Asp Cys Ala Ala  Ser Asp Val Thr Ala  Thr Arg Leu 
    2885                 2890                 2895             


Ala Asp  Ala Phe Arg Glu His  Ser Ala Ala Cys Thr  Thr Met Arg 
    2900                 2905                 2910             


Trp Pro  Leu His Asp Asp Gln  Leu Ala Ala Ala Asp  Gln Leu Arg 
    2915                 2920                 2925             


Asp Gln  Val Gly Ser Asp Glu  Phe Ser Gly Val Val  Val Leu Thr 
    2930                 2935                 2940             


Gly Pro  Asn Thr Gly Thr Pro  His Gln Gly Ser Ala  Asp Arg Gly 
    2945                 2950                 2955             


Ala Glu  Tyr Val Arg Arg Leu  Val Gly Ile Ala Arg  Glu Leu Ser 
    2960                 2965                 2970             


Asp Leu  Pro Gly Ala Val Pro  Arg Met Tyr Val Val  Thr Arg Gly 
    2975                 2980                 2985             


Ala Gln  Arg Val Leu Ala Asp  Asp Cys Val Asn Leu  Glu Gln Gly 
    2990                 2995                 3000             


Gly Leu  Arg Gly Leu Leu Arg  Thr Ile Gly Ala Glu  His Pro His 
    3005                 3010                 3015             


Leu Arg  Ala Thr Gln Ile Asp  Val Asp Glu Gln Thr  Gly Val Glu 
    3020                 3025                 3030             


Gln Leu  Ala Arg Gln Leu Leu  Ala Thr Ser Glu Glu  Asp Glu Thr 
    3035                 3040                 3045             


Ala Trp  Arg Asp Asn Glu Trp  Tyr Val Ala Arg Leu  Cys Pro Thr 
    3050                 3055                 3060             


Pro Leu  Arg Pro Gln Glu Arg  Arg Thr Ile Val Ala  Asp His Gln 
    3065                 3070                 3075             


Gln Ser  Gly Met Arg Leu Gln  Ile Arg Thr Pro Gly  Ala Ile Asp 
    3080                 3085                 3090             


Ser Val  Ala Phe Glu Pro Ala  Pro Asp Val Glu Gln  Pro Leu Arg 
    3095                 3100                 3105             


Ala Gly  Glu Val Arg Val Asp  Val Arg Ala Thr Gly  Val Asn Phe 
    3110                 3115                 3120             


Arg Asp  Val Leu Leu Ala Leu  Gly Met Tyr Pro Gln  Lys Ala Asp 
    3125                 3130                 3135             


Met Gly  Thr Glu Ala Ala Gly  Val Val Thr Ala Val  Gly Pro Asp 
    3140                 3145                 3150             


Val Asp  Ala Phe Ala Pro Gly  Asp Arg Val Leu Gly  Leu Phe Gln 
    3155                 3160                 3165             


Gly Ala  Phe Ala Pro Ile Ala  Val Thr Asp His Arg  Leu Leu Ala 
    3170                 3175                 3180             


Arg Val  Pro Asp Gly Trp Ser  Asp Ala Asp Ala Ala  Ala Val Pro 
    3185                 3190                 3195             


Ile Ala  Tyr Thr Thr Ala His  Tyr Ala Leu His Asp  Leu Ala Gly 
    3200                 3205                 3210             


Leu Arg  Ala Gly Gln Ser Val  Leu Ile His Ala Ala  Ala Gly Gly 
    3215                 3220                 3225             


Val Gly  Met Ala Ala Val Ala  Leu Ala Arg Arg Ala  Gly Ala Glu 
    3230                 3235                 3240             


Val Leu  Ala Thr Ala Gly Pro  Ala Lys His Gly Thr  Leu Arg Ala 
    3245                 3250                 3255             


Leu Gly  Leu Asp Asp Glu His  Ile Ala Ser Ser Arg  Glu Thr Gly 
    3260                 3265                 3270             


Phe Ala  Arg Lys Phe Arg Glu  Arg Thr Gly Gly Arg  Gly Val Asp 
    3275                 3280                 3285             


Val Val  Leu Asn Ser Leu Thr  Gly Glu Leu Leu Asp  Glu Ser Ala 
    3290                 3295                 3300             


Asp Leu  Leu Ala Glu Asp Gly  Val Phe Val Glu Met  Gly Lys Thr 
    3305                 3310                 3315             


Asp Leu  Arg Asp Ala Gly Asp  Phe Arg Gly Arg Tyr  Ala Pro Phe 
    3320                 3325                 3330             


Asp Leu  Gly Glu Ala Gly Asp  Asp Arg Leu Gly Glu  Ile Leu Arg 
    3335                 3340                 3345             


Glu Val  Val Gly Leu Leu Gly  Ala Gly Glu Leu Asp  Arg Leu Pro 
    3350                 3355                 3360             


Val Ser  Ala Trp Glu Leu Gly  Ile Pro Gln Thr Gly  Lys Ser Leu 
    3365                 3370                 3375             


Val Thr  Leu Pro Pro Glu Gln  Ala Gln Val Phe Arg  Pro Asp Gly 
    3380                 3385                 3390             


Thr Val  Leu Ile Thr Gly Gly  Thr Gly Thr Leu Gly  Arg Leu Leu 
    3395                 3400                 3405             


Ala Arg  His Leu Val Thr Glu  His Gly Val Arg His  Leu Leu Leu 
    3410                 3415                 3420             


Val Ser  Arg Arg Gly Ala Asp  Ala Pro Gly Ser Asp  Glu Leu Arg 
    3425                 3430                 3435             


Ala Glu  Ile Glu Asp Leu Gly  Ala Ser Ala Glu Ile  Ala Ala Cys 
    3440                 3445                 3450             


Asp Thr  Ala Asp Arg Asp Ala  Leu Ser Ala Leu Leu  Asp Gly Leu 
    3455                 3460                 3465             


Pro Arg  Pro Leu Thr Gly Val  Val His Ala Ala Gly  Val Leu Ala 
    3470                 3475                 3480             


Asp Gly  Leu Val Thr Ser Ile  Asp Glu Pro Ala Val  Glu Gln Val 
    3485                 3490                 3495             


Leu Arg  Ala Lys Val Asp Ala  Ala Trp Asn Leu His  Glu Leu Thr 
    3500                 3505                 3510             


Ala Asn  Thr Gly Leu Ser Phe  Phe Val Leu Phe Ser  Ser Ala Ala 
    3515                 3520                 3525             


Ser Val  Leu Ala Gly Pro Gly  Gln Gly Val Tyr Ala  Ala Ala Asn 
    3530                 3535                 3540             


Glu Ser  Leu Asn Ala Leu Ala  Ala Leu Arg Arg Thr  Arg Gly Leu 
    3545                 3550                 3555             


Pro Ala  Lys Ala Leu Gly Trp  Gly Leu Trp Ala Ile  Gly Arg Ala 
    3560                 3565                 3570             


Ile Ala  Phe Ala Glu Gln Thr  Gly Asp Ala Ile Ala  Pro Glu Glu 
    3575                 3580                 3585             


Gly Ala  Tyr Ala Phe Glu Thr  Leu Leu Arg His Asn  Arg Ala Tyr 
    3590                 3595                 3600             


Ser Gly  Tyr Ala Pro Val Ile  Gly Ser Pro Trp Leu  Thr Ala Phe 
    3605                 3610                 3615             


Ala Gln  His Ser Pro Phe Ala  Glu Lys Phe Gln Ser  Leu Gly Gln 
    3620                 3625                 3630             


Asn Arg  Ser Gly Thr Ser Lys  Phe Leu Ala Glu Leu  Val Asp Leu 
    3635                 3640                 3645             


Pro Arg  Glu Glu Trp Pro Asp  Arg Leu Arg Arg Leu  Leu Glu Leu 
    3650                 3655                 3660             


Val Arg  Ser His Ala Ala Ala  Val Ser Gly Tyr Gly  Ser Ala Asp 
    3665                 3670                 3675             


Gln Leu  Pro Glu Arg Lys Ala  Phe Lys Asp Leu Gly  Phe Asp Ser 
    3680                 3685                 3690             


Leu Ala  Ala Val Glu Leu Arg  Asn Arg Leu Gly Thr  Ala Thr Gly 
    3695                 3700                 3705             


Val Arg  Leu Pro Ser Thr Leu  Val Phe Asp His Pro  Thr Pro Leu 
    3710                 3715                 3720             


Ala Val  Ala Glu His Leu Arg  Asp Arg Leu Thr Ser  Gly Glu Asp 
    3725                 3730                 3735             


Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr 
    3740                 3745                 3750             


Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu His Arg  Ala Arg Leu 
    3755                 3760                 3765             


Val Cys  Phe Pro His Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp 
    3770                 3775                 3780             


Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp Val His  Ala Val Gln 
    3785                 3790                 3795             


Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr 
    3800                 3805                 3810             


Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser 
    3815                 3820                 3825             


Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly His Ser  Met Gly Ala 
    3830                 3835                 3840             


Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly 
    3845                 3850                 3855             


Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg 
    3860                 3865                 3870             


Val His  Glu Arg Arg Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val 
    3875                 3880                 3885             


Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp 
    3890                 3895                 3900             


Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr 
    3905                 3910                 3915             


Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg 
    3920                 3925                 3930             


Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala 
    3935                 3940                 3945             


Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His Ser Val  Ile Pro Gly 
    3950                 3955                 3960             


Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln 
    3965                 3970                 3975             


Val Thr  Glu Val Ala Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala 
    3980                 3985                 3990             


Gly Leu  Ala Gly 
    3995         


<210>  136
<211>  8787
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-Ser

<400>  136
atgaacccac cctgcgggcc agtccgtgcg aattgcgtac acatatccat agatttcccc       60

atgccagttt ccaaagtttc cggtcctcga tcaaggacaa ccagccggag gacacccgtc      120

cggattgggg ccgtggtggt ggcaagctcg actagcgaac tccttgatgg gctcgcagcg      180

gttgctgatg gtaggccaca cgccagcgta gttaggggcg ttgcgcgccc ttctgcgccg      240

gttgtattcg ttttcccagg tcaaggagcg caatgggctg ggatggcggg ggagctactc      300

ggggagagtc gggtctttgc agccgctatg gacgcctgcg cgagggcgtt cgaacctgta      360

accgattgga cattggccca agttttggat tcaccagagc aatcccggcg tgtagaggtc      420

gtccaacccg ccctttttgc agtgcagacc tctttggctg cactctggag atctttcggc      480

gtgacacccg acgcagtcgt agggcactct atcggggagc ttgcggcggc gcacgtctgt      540

ggggcagccg gggcagctga cgcggcaaga gctgccgcac tgtggtcacg agaaatgatc      600

ccactagtgg ggaacggtga catggcggcg gttgcactct cggcagatga gattgaacca      660

cggatcgccc gttgggacga cgacgtcgtg cttgctggtg ttaatggtcc ccgctcggtt      720

ttactaaccg gcagccctga accagtagca agaagggtac aagaactttc ggcagaggga      780

gttcgggcac aggtcattaa tgtgagcatg gcggcccatt ccgcgcaggt ggacgatatt      840

gcagaaggga tgagatcggc tctggcgtgg tttgccccag gcgggtccga agttccattt      900

tacgccagcc tcactggggg agccgtggac acgcgagaac tcgttgcgga ttactggcga      960

cgctcattca gactgcccgt tcgtttcgat gaagctataa gatcagccct ggaagttggg     1020

ccaggtacat tcgtcgaggc ctcaccccac ccagtcctgg cggctgccct acagcagaca     1080

ctggacgcag aggggtcgtc ggcagcggtg gtccccacat tacagcgggg gcaaggcgga     1140

atgcgtcggt tcctcttggc agcggcacag gcattcactg gaggagtggc cgtcgattgg     1200

accgcggcct atgatgatgt ggggcctaac ccggccctat gtcgatcgtc tcggcgccca     1260

agacggaaaa cttcgcgacc gtcaccagct tcgacgggaa caagacatag aacttgctgc     1320

gaacggctgc tcgccgtcgt gaacggcgaa actgccgcat tagccggacg tgaagcagat     1380

gcagaggcaa cctttcgaga gcttgggtta gattccgttc tggcggccca gctcagagct     1440

aaagtatccg cggcgatagg tcgagaagtc aatattgcac tactctatga ccacccaacc     1500

ccgagagcac tcgcagaggc acttgctgcc attcagacag gcgcatcact gtcaattccg     1560

gcaatccaat cgcgcagcaa ccgtgaccag cacttgccct tagtagctgc gcaacctgga     1620

atatggatgg ccgagaagtt atctgaacta ccatcagcgt ggagcgtagc gcattacgtg     1680

gagctcactg gtgaggttga ctcgcctctt ttggccaggg cggtagtggc tggccttgca     1740

caagctgaca ccttaagaat gcgtttcaca gaggataatg gggaagtttg gcaatgggta     1800

gacgatgcgt taacatttga gttaccggaa atcatagacc tgcgcactaa catagaccct     1860

cacgggacag ctcaggcctt gatgcaagcg gacctgcaac aggacctacg tgtggattcg     1920

gggaagcctc tggtcttcca tcagctaatt caagtagcgg acaatcgctg gtactggtat     1980

caaaggtacc accacttgct tgtggacggg ttcagttttc cagcgataac caggcaaata     2040

gccaacattt attgcacttg gttgcgagga gagcctacgc ccgcatcccc cttcacgcca     2100

ttcgcagacg ttgttgagga ataccaacag tatcgcgaga gcgaagcgtg gcaacgcgat     2160

gcggcattct gggcggagca acgacggcaa ctaccgcctc ccgcatccct atcacctgcc     2220

ccgctccccg gccggtccgc gtcagccgac attctacggc taaagctgga gttcacagat     2280

ggtgaatttc gacagcttgc tacacaactc agcggggtac aaaggacaga cctagcgctc     2340

gctctggctg cattatggct aggacgactt tgcaatcgaa tggactacgc ggcgggtttc     2400

atatttatgc gccggctcgg cagcgcagcg ttgaccgcaa cgggtccagt tttaaatgtt     2460

cttcctttgg gaatccacat aggcaaccca agcttctctg agcttctcac cagggttcgc     2520

gaggtcgcct taggcgcgta tgcacaccaa catattcctt ttgagatgtt agtagaggca     2580

ctgcaaccag agcgaaacct tagccatact cctctcttcc aagtgatgtt tgtccttcag     2640

aatgcgcccg cgtcccaatt agagttaacc gggatcaccg caaacccaat taaggttaaa     2700

tcaactacca cgaagttcga cctaacttta atcatgcaaa acacagctag cggattagta     2760

ggtgtttggg agtacaacac ggatttattc gacgcgtcaa cgattgagcg aatgacaggg     2820

cactttgtaa ccctcctcga gggcgttatc gccaatccac aacagccgat ctctcaactt     2880

cctattttaa ctacagtgga gcaacagcaa cttttagtcg agtggaataa cacgcaaacc     2940

gactaccccg ctgataagtg tatacatcaa ttattcgagg aacaggtcga gcgcacacca     3000

gacgccgttg ctgtcgtctt tgggaatcag caactcagct atcgagagat gcgcgaacaa     3060

gtggttgcac tcgccaattt attacgtgag cggggagtca agccaggaga ctccgttgcc     3120

gtggccttac cacgctctgt tttcttaacc cttgcactac acgcgattgt cgaggcaggt     3180

gccgcctggc tacctcttga cacaggatat cctgacgata gattaaaaat gatgctcgag     3240

gatgcacggc cttcccttct gatcacaaca gacgatcaat taccccgctt cagtgacgta     3300

cctaatctga cctcactctg ttacaacgct cccttgacgc ctcaagggag cgccccttta     3360

cagctgtctc aacctcacca tactgcatat atcatcttta caagtggttc tacgggacgc     3420

cccaagggag taatggttgg tcagactgcg attgtaaatc gtctgttgtg gatgcaaaac     3480

cactaccctt tgacggggga ggacgttgta gcccaaaaga ctccttgctc gttcgatgtc     3540

tcagtctggg agttcttttg gccatttata gcaggggcca aattagttat ggcggagccg     3600

gaagcccacc gagacccact tgcgatgcag caattctttg ctgagtatgg tgtcaccact     3660

acacatttcg tcccatcgat gttagcggcc ttcgtggctt ctcttactcc acaaacggct     3720

aggcaatctt gtgccacact aaagcaagtc ttctgctccg gcgaggcatt acctgcagac     3780

ttgtgccggg aatggcagca actcacagga gctccattgc acaatctata cggaccgacc     3840

gaggccgcag tagacgtatc ttggtatcct gcgtttggcg aggagttagc gcaagtaaga     3900

ggttcgtcag taccaatagg ataccccgta tggaacacgg ggcttcggat actggacgcg     3960

atgatgcatc cggtcccacc aggagtcgcg ggcgatttat acctgactgg gatacagctg     4020

gcccaaggtt acctagggag acctgacctt acggcgtcga ggttcatagc ggatccgttt     4080

gctccgggtg agcgcatgta ccgtacgggc gacgtcgcgc gatggctaga taatggcgcc     4140

gtagagtatc ttggtagatc agacgatcag ttaaagatac ggggacaacg aatagagctt     4200

ggggaaatag accgggtaat gcaggctttg ccagatgtcg agcaagcggt ggcttcgtgt     4260

gctattgcgc gggaggacat acctgggaac aaacaccttg tagcgtacat agttcctcaa     4320

gaggagcaaa catgcactga gcgatcgagg tccacactta cagtttcgtt cgtccggagt     4380

ttccttaagg agaaactccc cgaatatatg gtaccgagcg caatagtgat tctagacgct     4440

ctccccctga ctcctaatgg aaagctagac cggcgggcgt tacccgcccc tgacctgcac     4500

tcacaacttg agacaattat tgctgcggct ttctcgagcc tgctcgggtg cgacgtacaa     4560

gacgcggatg ctgacttttt cgcgctaggt ggccattcgc tgcttgccat gaagctagcc     4620

gctcagcttt cccgacaagt agcgcggcag gtgacaccag gccaagttat ggtagcttcg     4680

actgtcgcaa agctcgcaac gatcatagac gcggagttag ataaatacgt cgctccaagg     4740

aacccgatat tggcttccgc tcgtgctccg cgtgacgtcc gccaaacagc tcacgctgac     4800

gctgctgaac cggctggcga cgacggcctt cagcacttgc ccttagtagc tgcgcaacct     4860

ggaatatgga tggccgagaa gttatctgaa ctaccatcag cgtggagcgt agcgcattac     4920

gtggagctca ctggtgaggt tgactcgcct cttttggcca gggcggtagt ggctggcctt     4980

gcacaagctg acaccttaag aatgcgtttc acagaggata atggggaagt ttggcaatgg     5040

gtagacgatg cgttaacatt tgagttaccg gaaatcatag acctgcgcac taacatagac     5100

cctcacggga cagctcaggc cttgatgcaa gcggacctgc aacaggacct acgtgtggat     5160

tcggggaagc ctctggtctt ccatcagcta attcaagtag cggacaatcg ctggtactgg     5220

tatcaaaggt accaccactt gcttgtggac gggttcagtt ttccagcgat aaccaggcaa     5280

atagccaaca tttattgcac ttggttgcga ggagagccta cgcccgcatc ccccttcacg     5340

ccattcgcag acgttgttga ggaataccaa cagtatcgcg agagcgaagc gtggcaacgc     5400

gatgcggcat tctgggcgga gcaacgacgg caactaccgc ctcccgcatc cctatcacct     5460

gccccgctcc ccggccggtc cgcgtcagcc gacattctac ggctaaagct ggagttcaca     5520

gatggtgaat ttcgacagct tgctacacaa ctcagcgggg tacaaaggac agacctagcg     5580

ctcgctctgg ctgcattatg gctaggacga ctttgcaatc gaatggacta cgcggcgggt     5640

ttcatattta tgcgccggct cggcagcgca gcgttgaccg caacgggtcc agttttaaat     5700

gttcttcctt tgggaatcca cataggcaac ccaagcttct ctgagcttct caccagggtt     5760

cgcgaggtcg ccttaggcgc gtatgcacac caacatattc cttttgagat gttagtagag     5820

gcactgcaac cagagcgaaa ccttagccat actcctctct tccaagtgat gtttgtcctt     5880

cagaatgcgc ccgcgtccca attagagtta accgggatca ccgcaaaccc aattaaggtt     5940

aaatcaacta ccacgaagtt cgacctaact ttaatcatgc aaaacacagc tagcggatta     6000

gtaggtgttt gggagtacaa cacggattta ttcgacgcgt caacgattga gcgaatgaca     6060

gggcactttg taaccctcct cgagggcgtt atcgccaatc cacaacagcc gatctctcaa     6120

cttcctattt taactacagt ggagcaacag caacttttag tcgagtggaa taacacgcaa     6180

accgactacc ccgctgataa gtgtatacat caattattcg aggaacaggt cgagcgcaca     6240

ccagacgccg ttgctgtcgt ctttgggaat cagcaactca gctatcgaga gatgcgcgaa     6300

caagtggttg cactcgccaa tttattacgt gagcggggag tcaagccagg agactccgtt     6360

gccgtggcct taccacgctc tgttttctta acccttgcac tacacgcgat tgtcgaggca     6420

ggtgccgcct ggctacctct tgacacagga tatcctgacg atagattaaa aatgatgctc     6480

gaggatgcac ggccttccct tctgatcaca acagacgatc aattaccccg cttcagtgac     6540

gtacctaatc tgacctcact ctgttacaac gctcccttga cgcctcaagg gagcgcccct     6600

ttacagctgt ctcaacctca ccatactgca tatatcatct ttacaagtgg ttctacggga     6660

cgccccaagg gagtaatggt tggtcagact gcgattgtaa atcgtctgtt gtggatgcaa     6720

aaccactacc ctttgacggg ggaggacgtt gtagcccaaa agactccttg ctcgttcgat     6780

gtctcagtct gggagttctt ttggccattt atagcagggg ccaaattagt tatggcggag     6840

ccggaagccc accgagaccc acttgcgatg cagcaattct ttgctgagta tggtgtcacc     6900

actacacatt tcgtcccatc gatgttagcg gccttcgtgg cttctcttac tccacaaacg     6960

gctaggcaat cttgtgccac actaaagcaa gtcttctgct ccggcgaggc attacctgca     7020

gacttgtgcc gggaatggca gcaactcaca ggagctccat tgcacaatct atacggaccg     7080

accgaggccg cagtagacgt atcttggtat cctgcgtttg gcgaggagtt agcgcaagta     7140

agaggttcgt cagtaccaat aggatacccc gtatggaaca cggggcttcg gatactggac     7200

gcgatgatgc atccggtccc accaggagtc gcgggcgatt tatacctgac tgggatacag     7260

ctggcccaag gttacctagg gagacctgac cttacggcgt cgaggttcat agcggatccg     7320

tttgctccgg gtgagcgcat gtaccgtacg ggcgacgtcg cgcgatggct agataatggc     7380

gccgtagagt atcttggtag atcagacgat cagttaaaga tacggggaca acgaatagag     7440

cttggggaaa tagaccgggt aatgcaggct ttgccagatg tcgagcaagc ggtggcttcg     7500

tgtgctattg cgcgggagga catacctggg aacaaacacc ttgtagcgta catagttcct     7560

caagaggagc aaacatgcac tgagcgatcg aggtccacac ttacagtttc gttcgtccgg     7620

agtttcctta aggagaaact ccccgaatat atggtaccga gcgcaatagt gattctagac     7680

gctctccccc tgactcctaa tggaaagcta gaccggcggg cgttacccgc ccctgacctg     7740

cactcacaac ttgagacaat tattgctgcg gctttctcga gcctgctcgg gtgcgacgta     7800

caagacgcgg atgctgactt tttcgcgcta ggtggccatt cgctgcttgc catgaagcta     7860

gccgctcagc tttcccgaca agtagcgcgg caggtgacac caggccaagt tatggtagct     7920

tcgactgtcg caaagctcgc aacgatcata gacgcggagt tagataaata cgtcgctcca     7980

aggaacccga taacatccgg ggaagataac cctatccccc tatgtcaagg cgatggggag     8040

gagatgagca catggctacg tcgttttgga cccccagtcg aacatcgggc caggctagtg     8100

tgtttccccc acgcaggcgc agcggcggat tcatacttag acctagcaag agcgttagca     8160

ccagagatcg atgttcatgc tgttcaatac cccggcaggc aagacagaag ggacgaggag     8220

ccattaggaa ccgcaggtga aattgcagat gaagtggcag cggtgctacg tgcgtcggga     8280

ggggatgggc cttttgcact tttcggccac agtatgggcg ccctcatcgc gtacgagaca     8340

gcaaggcgat tagagaggga accgggaggg ggacccttac gtttattcgt gagcggacaa     8400

acagcgccac gtgtccatga acgaagaact gatctgcccg gtgacgatgg actcgtggac     8460

gagcttaggc gacttggcac ctccgaggca gcgctcgcag acgaagccct gctggctatg     8520

tctctcccgg tgctcagggc ggattatagg gtgttaagat cctacgcttg ggcggatggt     8580

cccccactac gcgccggtat aactgccctc tgcggtgatg cagacccact aactgcaaca     8640

ggggatgcgg aacgctggtt acaacattcc gtgattccgg gtcggacacg gacatttccc     8700

ggtgggcatt tttatttagg ggaacaagtg accgaggtgg caggggctgt ccgtagagat     8760

ttactgagag cagggttagc gggttga                                         8787


<210>  137
<211>  2928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ac-Ser-Ser

<400>  137

Met Asn Pro Pro Cys Gly Pro Val Arg Ala Asn Cys Val His Ile Ser 
1               5                   10                  15      


Ile Asp Phe Pro Met Pro Val Ser Lys Val Ser Gly Pro Arg Ser Arg 
            20                  25                  30          


Thr Thr Ser Arg Arg Thr Pro Val Arg Ile Gly Ala Val Val Val Ala 
        35                  40                  45              


Ser Ser Thr Ser Glu Leu Leu Asp Gly Leu Ala Ala Val Ala Asp Gly 
    50                  55                  60                  


Arg Pro His Ala Ser Val Val Arg Gly Val Ala Arg Pro Ser Ala Pro 
65                  70                  75                  80  


Val Val Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Ala 
                85                  90                  95      


Gly Glu Leu Leu Gly Glu Ser Arg Val Phe Ala Ala Ala Met Asp Ala 
            100                 105                 110         


Cys Ala Arg Ala Phe Glu Pro Val Thr Asp Trp Thr Leu Ala Gln Val 
        115                 120                 125             


Leu Asp Ser Pro Glu Gln Ser Arg Arg Val Glu Val Val Gln Pro Ala 
    130                 135                 140                 


Leu Phe Ala Val Gln Thr Ser Leu Ala Ala Leu Trp Arg Ser Phe Gly 
145                 150                 155                 160 


Val Thr Pro Asp Ala Val Val Gly His Ser Ile Gly Glu Leu Ala Ala 
                165                 170                 175     


Ala His Val Cys Gly Ala Ala Gly Ala Ala Asp Ala Ala Arg Ala Ala 
            180                 185                 190         


Ala Leu Trp Ser Arg Glu Met Ile Pro Leu Val Gly Asn Gly Asp Met 
        195                 200                 205             


Ala Ala Val Ala Leu Ser Ala Asp Glu Ile Glu Pro Arg Ile Ala Arg 
    210                 215                 220                 


Trp Asp Asp Asp Val Val Leu Ala Gly Val Asn Gly Pro Arg Ser Val 
225                 230                 235                 240 


Leu Leu Thr Gly Ser Pro Glu Pro Val Ala Arg Arg Val Gln Glu Leu 
                245                 250                 255     


Ser Ala Glu Gly Val Arg Ala Gln Val Ile Asn Val Ser Met Ala Ala 
            260                 265                 270         


His Ser Ala Gln Val Asp Asp Ile Ala Glu Gly Met Arg Ser Ala Leu 
        275                 280                 285             


Ala Trp Phe Ala Pro Gly Gly Ser Glu Val Pro Phe Tyr Ala Ser Leu 
    290                 295                 300                 


Thr Gly Gly Ala Val Asp Thr Arg Glu Leu Val Ala Asp Tyr Trp Arg 
305                 310                 315                 320 


Arg Ser Phe Arg Leu Pro Val Arg Phe Asp Glu Ala Ile Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Gly Pro Gly Thr Phe Val Glu Ala Ser Pro His Pro Val 
            340                 345                 350         


Leu Ala Ala Ala Leu Gln Gln Thr Leu Asp Ala Glu Gly Ser Ser Ala 
        355                 360                 365             


Ala Val Val Pro Thr Leu Gln Arg Gly Gln Gly Gly Met Arg Arg Phe 
    370                 375                 380                 


Leu Leu Ala Ala Ala Gln Ala Phe Thr Gly Gly Val Ala Val Asp Trp 
385                 390                 395                 400 


Thr Ala Ala Tyr Asp Asp Val Gly Pro Asn Pro Ala Leu Cys Arg Ser 
                405                 410                 415     


Ser Arg Arg Pro Arg Arg Lys Thr Ser Arg Pro Ser Pro Ala Ser Thr 
            420                 425                 430         


Gly Thr Arg His Arg Thr Cys Cys Glu Arg Leu Leu Ala Val Val Asn 
        435                 440                 445             


Gly Glu Thr Ala Ala Leu Ala Gly Arg Glu Ala Asp Ala Glu Ala Thr 
    450                 455                 460                 


Phe Arg Glu Leu Gly Leu Asp Ser Val Leu Ala Ala Gln Leu Arg Ala 
465                 470                 475                 480 


Lys Val Ser Ala Ala Ile Gly Arg Glu Val Asn Ile Ala Leu Leu Tyr 
                485                 490                 495     


Asp His Pro Thr Pro Arg Ala Leu Ala Glu Ala Leu Ala Ala Ile Gln 
            500                 505                 510         


Thr Gly Ala Ser Leu Ser Ile Pro Ala Ile Gln Ser Arg Ser Asn Arg 
        515                 520                 525             


Asp Gln His Leu Pro Leu Val Ala Ala Gln Pro Gly Ile Trp Met Ala 
    530                 535                 540                 


Glu Lys Leu Ser Glu Leu Pro Ser Ala Trp Ser Val Ala His Tyr Val 
545                 550                 555                 560 


Glu Leu Thr Gly Glu Val Asp Ser Pro Leu Leu Ala Arg Ala Val Val 
                565                 570                 575     


Ala Gly Leu Ala Gln Ala Asp Thr Leu Arg Met Arg Phe Thr Glu Asp 
            580                 585                 590         


Asn Gly Glu Val Trp Gln Trp Val Asp Asp Ala Leu Thr Phe Glu Leu 
        595                 600                 605             


Pro Glu Ile Ile Asp Leu Arg Thr Asn Ile Asp Pro His Gly Thr Ala 
    610                 615                 620                 


Gln Ala Leu Met Gln Ala Asp Leu Gln Gln Asp Leu Arg Val Asp Ser 
625                 630                 635                 640 


Gly Lys Pro Leu Val Phe His Gln Leu Ile Gln Val Ala Asp Asn Arg 
                645                 650                 655     


Trp Tyr Trp Tyr Gln Arg Tyr His His Leu Leu Val Asp Gly Phe Ser 
            660                 665                 670         


Phe Pro Ala Ile Thr Arg Gln Ile Ala Asn Ile Tyr Cys Thr Trp Leu 
        675                 680                 685             


Arg Gly Glu Pro Thr Pro Ala Ser Pro Phe Thr Pro Phe Ala Asp Val 
    690                 695                 700                 


Val Glu Glu Tyr Gln Gln Tyr Arg Glu Ser Glu Ala Trp Gln Arg Asp 
705                 710                 715                 720 


Ala Ala Phe Trp Ala Glu Gln Arg Arg Gln Leu Pro Pro Pro Ala Ser 
                725                 730                 735     


Leu Ser Pro Ala Pro Leu Pro Gly Arg Ser Ala Ser Ala Asp Ile Leu 
            740                 745                 750         


Arg Leu Lys Leu Glu Phe Thr Asp Gly Glu Phe Arg Gln Leu Ala Thr 
        755                 760                 765             


Gln Leu Ser Gly Val Gln Arg Thr Asp Leu Ala Leu Ala Leu Ala Ala 
    770                 775                 780                 


Leu Trp Leu Gly Arg Leu Cys Asn Arg Met Asp Tyr Ala Ala Gly Phe 
785                 790                 795                 800 


Ile Phe Met Arg Arg Leu Gly Ser Ala Ala Leu Thr Ala Thr Gly Pro 
                805                 810                 815     


Val Leu Asn Val Leu Pro Leu Gly Ile His Ile Gly Asn Pro Ser Phe 
            820                 825                 830         


Ser Glu Leu Leu Thr Arg Val Arg Glu Val Ala Leu Gly Ala Tyr Ala 
        835                 840                 845             


His Gln His Ile Pro Phe Glu Met Leu Val Glu Ala Leu Gln Pro Glu 
    850                 855                 860                 


Arg Asn Leu Ser His Thr Pro Leu Phe Gln Val Met Phe Val Leu Gln 
865                 870                 875                 880 


Asn Ala Pro Ala Ser Gln Leu Glu Leu Thr Gly Ile Thr Ala Asn Pro 
                885                 890                 895     


Ile Lys Val Lys Ser Thr Thr Thr Lys Phe Asp Leu Thr Leu Ile Met 
            900                 905                 910         


Gln Asn Thr Ala Ser Gly Leu Val Gly Val Trp Glu Tyr Asn Thr Asp 
        915                 920                 925             


Leu Phe Asp Ala Ser Thr Ile Glu Arg Met Thr Gly His Phe Val Thr 
    930                 935                 940                 


Leu Leu Glu Gly Val Ile Ala Asn Pro Gln Gln Pro Ile Ser Gln Leu 
945                 950                 955                 960 


Pro Ile Leu Thr Thr Val Glu Gln Gln Gln Leu Leu Val Glu Trp Asn 
                965                 970                 975     


Asn Thr Gln Thr Asp Tyr Pro Ala Asp Lys Cys Ile His Gln Leu Phe 
            980                 985                 990         


Glu Glu Gln Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
        995                 1000                 1005             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    1010                 1015                 1020             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    1025                 1030                 1035             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    1040                 1045                 1050             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    1055                 1060                 1065             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    1070                 1075                 1080             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    1085                 1090                 1095             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    1100                 1105                 1110             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    1115                 1120                 1125             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    1130                 1135                 1140             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    1145                 1150                 1155             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    1160                 1165                 1170             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    1175                 1180                 1185             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    1190                 1195                 1200             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    1205                 1210                 1215             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    1220                 1225                 1230             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    1235                 1240                 1245             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    1250                 1255                 1260             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    1265                 1270                 1275             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    1280                 1285                 1290             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    1295                 1300                 1305             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    1310                 1315                 1320             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    1325                 1330                 1335             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    1340                 1345                 1350             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    1355                 1360                 1365             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    1370                 1375                 1380             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    1385                 1390                 1395             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    1400                 1405                 1410             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    1415                 1420                 1425             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    1430                 1435                 1440             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    1445                 1450                 1455             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    1460                 1465                 1470             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    1475                 1480                 1485             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    1490                 1495                 1500             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    1505                 1510                 1515             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    1520                 1525                 1530             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    1535                 1540                 1545             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    1550                 1555                 1560             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    1565                 1570                 1575             


Pro Arg  Asn Pro Ile Leu Ala  Ser Ala Arg Ala Pro  Arg Asp Val 
    1580                 1585                 1590             


Arg Gln  Thr Ala His Ala Asp  Ala Ala Glu Pro Ala  Gly Asp Asp 
    1595                 1600                 1605             


Gly Leu  Gln His Leu Pro Leu  Val Ala Ala Gln Pro  Gly Ile Trp 
    1610                 1615                 1620             


Met Ala  Glu Lys Leu Ser Glu  Leu Pro Ser Ala Trp  Ser Val Ala 
    1625                 1630                 1635             


His Tyr  Val Glu Leu Thr Gly  Glu Val Asp Ser Pro  Leu Leu Ala 
    1640                 1645                 1650             


Arg Ala  Val Val Ala Gly Leu  Ala Gln Ala Asp Thr  Leu Arg Met 
    1655                 1660                 1665             


Arg Phe  Thr Glu Asp Asn Gly  Glu Val Trp Gln Trp  Val Asp Asp 
    1670                 1675                 1680             


Ala Leu  Thr Phe Glu Leu Pro  Glu Ile Ile Asp Leu  Arg Thr Asn 
    1685                 1690                 1695             


Ile Asp  Pro His Gly Thr Ala  Gln Ala Leu Met Gln  Ala Asp Leu 
    1700                 1705                 1710             


Gln Gln  Asp Leu Arg Val Asp  Ser Gly Lys Pro Leu  Val Phe His 
    1715                 1720                 1725             


Gln Leu  Ile Gln Val Ala Asp  Asn Arg Trp Tyr Trp  Tyr Gln Arg 
    1730                 1735                 1740             


Tyr His  His Leu Leu Val Asp  Gly Phe Ser Phe Pro  Ala Ile Thr 
    1745                 1750                 1755             


Arg Gln  Ile Ala Asn Ile Tyr  Cys Thr Trp Leu Arg  Gly Glu Pro 
    1760                 1765                 1770             


Thr Pro  Ala Ser Pro Phe Thr  Pro Phe Ala Asp Val  Val Glu Glu 
    1775                 1780                 1785             


Tyr Gln  Gln Tyr Arg Glu Ser  Glu Ala Trp Gln Arg  Asp Ala Ala 
    1790                 1795                 1800             


Phe Trp  Ala Glu Gln Arg Arg  Gln Leu Pro Pro Pro  Ala Ser Leu 
    1805                 1810                 1815             


Ser Pro  Ala Pro Leu Pro Gly  Arg Ser Ala Ser Ala  Asp Ile Leu 
    1820                 1825                 1830             


Arg Leu  Lys Leu Glu Phe Thr  Asp Gly Glu Phe Arg  Gln Leu Ala 
    1835                 1840                 1845             


Thr Gln  Leu Ser Gly Val Gln  Arg Thr Asp Leu Ala  Leu Ala Leu 
    1850                 1855                 1860             


Ala Ala  Leu Trp Leu Gly Arg  Leu Cys Asn Arg Met  Asp Tyr Ala 
    1865                 1870                 1875             


Ala Gly  Phe Ile Phe Met Arg  Arg Leu Gly Ser Ala  Ala Leu Thr 
    1880                 1885                 1890             


Ala Thr  Gly Pro Val Leu Asn  Val Leu Pro Leu Gly  Ile His Ile 
    1895                 1900                 1905             


Gly Asn  Pro Ser Phe Ser Glu  Leu Leu Thr Arg Val  Arg Glu Val 
    1910                 1915                 1920             


Ala Leu  Gly Ala Tyr Ala His  Gln His Ile Pro Phe  Glu Met Leu 
    1925                 1930                 1935             


Val Glu  Ala Leu Gln Pro Glu  Arg Asn Leu Ser His  Thr Pro Leu 
    1940                 1945                 1950             


Phe Gln  Val Met Phe Val Leu  Gln Asn Ala Pro Ala  Ser Gln Leu 
    1955                 1960                 1965             


Glu Leu  Thr Gly Ile Thr Ala  Asn Pro Ile Lys Val  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Lys Phe Asp Leu Thr  Leu Ile Met Gln Asn  Thr Ala Ser 
    1985                 1990                 1995             


Gly Leu  Val Gly Val Trp Glu  Tyr Asn Thr Asp Leu  Phe Asp Ala 
    2000                 2005                 2010             


Ser Thr  Ile Glu Arg Met Thr  Gly His Phe Val Thr  Leu Leu Glu 
    2015                 2020                 2025             


Gly Val  Ile Ala Asn Pro Gln  Gln Pro Ile Ser Gln  Leu Pro Ile 
    2030                 2035                 2040             


Leu Thr  Thr Val Glu Gln Gln  Gln Leu Leu Val Glu  Trp Asn Asn 
    2045                 2050                 2055             


Thr Gln  Thr Asp Tyr Pro Ala  Asp Lys Cys Ile His  Gln Leu Phe 
    2060                 2065                 2070             


Glu Glu  Gln Val Glu Arg Thr  Pro Asp Ala Val Ala  Val Val Phe 
    2075                 2080                 2085             


Gly Asn  Gln Gln Leu Ser Tyr  Arg Glu Met Arg Glu  Gln Val Val 
    2090                 2095                 2100             


Ala Leu  Ala Asn Leu Leu Arg  Glu Arg Gly Val Lys  Pro Gly Asp 
    2105                 2110                 2115             


Ser Val  Ala Val Ala Leu Pro  Arg Ser Val Phe Leu  Thr Leu Ala 
    2120                 2125                 2130             


Leu His  Ala Ile Val Glu Ala  Gly Ala Ala Trp Leu  Pro Leu Asp 
    2135                 2140                 2145             


Thr Gly  Tyr Pro Asp Asp Arg  Leu Lys Met Met Leu  Glu Asp Ala 
    2150                 2155                 2160             


Arg Pro  Ser Leu Leu Ile Thr  Thr Asp Asp Gln Leu  Pro Arg Phe 
    2165                 2170                 2175             


Ser Asp  Val Pro Asn Leu Thr  Ser Leu Cys Tyr Asn  Ala Pro Leu 
    2180                 2185                 2190             


Thr Pro  Gln Gly Ser Ala Pro  Leu Gln Leu Ser Gln  Pro His His 
    2195                 2200                 2205             


Thr Ala  Tyr Ile Ile Phe Thr  Ser Gly Ser Thr Gly  Arg Pro Lys 
    2210                 2215                 2220             


Gly Val  Met Val Gly Gln Thr  Ala Ile Val Asn Arg  Leu Leu Trp 
    2225                 2230                 2235             


Met Gln  Asn His Tyr Pro Leu  Thr Gly Glu Asp Val  Val Ala Gln 
    2240                 2245                 2250             


Lys Thr  Pro Cys Ser Phe Asp  Val Ser Val Trp Glu  Phe Phe Trp 
    2255                 2260                 2265             


Pro Phe  Ile Ala Gly Ala Lys  Leu Val Met Ala Glu  Pro Glu Ala 
    2270                 2275                 2280             


His Arg  Asp Pro Leu Ala Met  Gln Gln Phe Phe Ala  Glu Tyr Gly 
    2285                 2290                 2295             


Val Thr  Thr Thr His Phe Val  Pro Ser Met Leu Ala  Ala Phe Val 
    2300                 2305                 2310             


Ala Ser  Leu Thr Pro Gln Thr  Ala Arg Gln Ser Cys  Ala Thr Leu 
    2315                 2320                 2325             


Lys Gln  Val Phe Cys Ser Gly  Glu Ala Leu Pro Ala  Asp Leu Cys 
    2330                 2335                 2340             


Arg Glu  Trp Gln Gln Leu Thr  Gly Ala Pro Leu His  Asn Leu Tyr 
    2345                 2350                 2355             


Gly Pro  Thr Glu Ala Ala Val  Asp Val Ser Trp Tyr  Pro Ala Phe 
    2360                 2365                 2370             


Gly Glu  Glu Leu Ala Gln Val  Arg Gly Ser Ser Val  Pro Ile Gly 
    2375                 2380                 2385             


Tyr Pro  Val Trp Asn Thr Gly  Leu Arg Ile Leu Asp  Ala Met Met 
    2390                 2395                 2400             


His Pro  Val Pro Pro Gly Val  Ala Gly Asp Leu Tyr  Leu Thr Gly 
    2405                 2410                 2415             


Ile Gln  Leu Ala Gln Gly Tyr  Leu Gly Arg Pro Asp  Leu Thr Ala 
    2420                 2425                 2430             


Ser Arg  Phe Ile Ala Asp Pro  Phe Ala Pro Gly Glu  Arg Met Tyr 
    2435                 2440                 2445             


Arg Thr  Gly Asp Val Ala Arg  Trp Leu Asp Asn Gly  Ala Val Glu 
    2450                 2455                 2460             


Tyr Leu  Gly Arg Ser Asp Asp  Gln Leu Lys Ile Arg  Gly Gln Arg 
    2465                 2470                 2475             


Ile Glu  Leu Gly Glu Ile Asp  Arg Val Met Gln Ala  Leu Pro Asp 
    2480                 2485                 2490             


Val Glu  Gln Ala Val Ala Ser  Cys Ala Ile Ala Arg  Glu Asp Ile 
    2495                 2500                 2505             


Pro Gly  Asn Lys His Leu Val  Ala Tyr Ile Val Pro  Gln Glu Glu 
    2510                 2515                 2520             


Gln Thr  Cys Thr Glu Arg Ser  Arg Ser Thr Leu Thr  Val Ser Phe 
    2525                 2530                 2535             


Val Arg  Ser Phe Leu Lys Glu  Lys Leu Pro Glu Tyr  Met Val Pro 
    2540                 2545                 2550             


Ser Ala  Ile Val Ile Leu Asp  Ala Leu Pro Leu Thr  Pro Asn Gly 
    2555                 2560                 2565             


Lys Leu  Asp Arg Arg Ala Leu  Pro Ala Pro Asp Leu  His Ser Gln 
    2570                 2575                 2580             


Leu Glu  Thr Ile Ile Ala Ala  Ala Phe Ser Ser Leu  Leu Gly Cys 
    2585                 2590                 2595             


Asp Val  Gln Asp Ala Asp Ala  Asp Phe Phe Ala Leu  Gly Gly His 
    2600                 2605                 2610             


Ser Leu  Leu Ala Met Lys Leu  Ala Ala Gln Leu Ser  Arg Gln Val 
    2615                 2620                 2625             


Ala Arg  Gln Val Thr Pro Gly  Gln Val Met Val Ala  Ser Thr Val 
    2630                 2635                 2640             


Ala Lys  Leu Ala Thr Ile Ile  Asp Ala Glu Leu Asp  Lys Tyr Val 
    2645                 2650                 2655             


Ala Pro  Arg Asn Pro Ile Thr  Ser Gly Glu Asp Asn  Pro Ile Pro 
    2660                 2665                 2670             


Leu Cys  Gln Gly Asp Gly Glu  Glu Met Ser Thr Trp  Leu Arg Arg 
    2675                 2680                 2685             


Phe Gly  Pro Pro Val Glu His  Arg Ala Arg Leu Val  Cys Phe Pro 
    2690                 2695                 2700             


His Ala  Gly Ala Ala Ala Asp  Ser Tyr Leu Asp Leu  Ala Arg Ala 
    2705                 2710                 2715             


Leu Ala  Pro Glu Ile Asp Val  His Ala Val Gln Tyr  Pro Gly Arg 
    2720                 2725                 2730             


Gln Asp  Arg Arg Asp Glu Glu  Pro Leu Gly Thr Ala  Gly Glu Ile 
    2735                 2740                 2745             


Ala Asp  Glu Val Ala Ala Val  Leu Arg Ala Ser Gly  Gly Asp Gly 
    2750                 2755                 2760             


Pro Phe  Ala Leu Phe Gly His  Ser Met Gly Ala Leu  Ile Ala Tyr 
    2765                 2770                 2775             


Glu Thr  Ala Arg Arg Leu Glu  Arg Glu Pro Gly Gly  Gly Pro Leu 
    2780                 2785                 2790             


Arg Leu  Phe Val Ser Gly Gln  Thr Ala Pro Arg Val  His Glu Arg 
    2795                 2800                 2805             


Arg Thr  Asp Leu Pro Gly Asp  Asp Gly Leu Val Asp  Glu Leu Arg 
    2810                 2815                 2820             


Arg Leu  Gly Thr Ser Glu Ala  Ala Leu Ala Asp Glu  Ala Leu Leu 
    2825                 2830                 2835             


Ala Met  Ser Leu Pro Val Leu  Arg Ala Asp Tyr Arg  Val Leu Arg 
    2840                 2845                 2850             


Ser Tyr  Ala Trp Ala Asp Gly  Pro Pro Leu Arg Ala  Gly Ile Thr 
    2855                 2860                 2865             


Ala Leu  Cys Gly Asp Ala Asp  Pro Leu Thr Ala Thr  Gly Asp Ala 
    2870                 2875                 2880             


Glu Arg  Trp Leu Gln His Ser  Val Ile Pro Gly Arg  Thr Arg Thr 
    2885                 2890                 2895             


Phe Pro  Gly Gly His Phe Tyr  Leu Gly Glu Gln Val  Thr Glu Val 
    2900                 2905                 2910             


Ala Gly  Ala Val Arg Arg Asp  Leu Leu Arg Ala Gly  Leu Ala Gly 
    2915                 2920                 2925             


<210>  138
<211>  10356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-Ser

<400>  138
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatcgtttc gatggcatgt     1920

cgtttaccgg gaggagtcaa tacgccccaa cggctctggg aattactacg ggagggtggt     1980

gaaaccttgt ccgggttccc aacggaccgt ggctgggacc tagcacggct tcaccaccct     2040

gatccggaca accccggaac gagctacgtt gataagggtg gatttctcga cgacgcggcg     2100

ggtttcgacg cagagttttt cggggtttca ccaagggaag ctgccgctat ggaccctcag     2160

caacgattac ttttagagac ctcgtgggag ctagttgaaa atgcgggcat agatccacat     2220

agcctgcgag ggacagcgac aggggtgttc ctaggagttg cgaagtttgg ttatggtgag     2280

gacacagcag cagcggaaga tgttgaaggt tattcagtta ccggtgttgc tcccgctgtg     2340

gcatctggcc gcatatccta cactatgggt ttagaaggtc cttccatctc ggtcgatacc     2400

gcatgctcaa gctcgctagt cgcgcttcat ctagccgtag agtccctccg aaagggtgag     2460

tcatctatgg cggtggtggg tggtgcagcc gttatggcga ctcctggggt atttgttgat     2520

ttttcacgcc aacgggcgct tgccgcagac ggccgttcca aagcgttcgg ggcaggtgca     2580

gatggttttg gtttcagcga gggagtcacg ctggttctac tagagcgttt aagtgaggcg     2640

cgtcgtaacg gtcatgaagt tctagctgta gtgcgcgggt ccgcgttaaa ccaggacgga     2700

gcgagcaacg gactttcagc accctccggc cctgcgcaac gtagagtaat aaggcaagcg     2760

ctcgaatcgt gtgggcttga accgggggat gttgacgcgg ttgaggcgca tggtactggt     2820

acagcactag gtgacccaat agaggccaat gcgctgttgg acacttacgg gcgagaccgt     2880

gatgcggatc gtccactttg gttggggtcc gttaagagca atattgggca cactcaagct     2940

gcggccgggg ttacaggact gctgaaggtt gtgttagcac tgcgcaatgg tgagctacct     3000

gcaacgttac atgtcgagga accaactcca cacgtcgatt ggtcctcagg tggtgtcgca     3060

ttactggcgg gtaatcaacc atggcgaagg ggagaaagga ccagaagggc ggcagtgagc     3120

gcctttggta tctccggtac aaatgctcac gtgatagtgg aagaggcgcc tcaggaagtt     3180

cgacccgccc ctggccaagg gctgtcgcca gccgtgtcca cgttagttgt tgcaggtaaa     3240

accatgcagc gtgtaagtgc gacagctgga atgcttgcag actggatgga gggtcctggg     3300

gccgatgttg cattggcgga tgtggcccat accctgaacc atcaccgatc aagacagccc     3360

aagttcggga cggttgtagc gcgtgacagg actcaggcga tagctgggct ccgtgcattg     3420

gcggctggtc aacatgctcc tggggtcgtc aacccagctg aaggttcccc aggaccaggc     3480

accgtgttcg tttttcccgg tcaaggttcg cagagggcag ggatggggga ggaactcgcg     3540

gcagcctttc ctgtcttcgc tcgaatacat cagcaagttt gggacctcct agatgttccc     3600

gacctcgacg ttaatgaaac cgggtacgcc caaccagcgc tgttcgcgct tcaggtcgcg     3660

ctctttggcc ttctggagtc gtggggtgtt aggccagatg cagtggtagg gcactcagtt     3720

ggtgagctgg ccgcggggta cgtgtccggt ctttggtcac tagaggacgc ctgcacacta     3780

gtctcagcaa gagcgcgcct aatgcaggca ctgcctgctg gaggggtgat ggcggcagtc     3840

cccgtctccg aggatgaggc gcgggccgtc ctgggcgagg gagttgaaat tgcggctgtg     3900

aatggaccct cgtccgttgt gctctcaggg gacgaggcgg cagtcttaca ggccgccgaa     3960

ggtctaggta agtggacgcg actgccgacc agccatgctt ttcactcagc gagaatggaa     4020

cccatgctag aagagtttcg ggccgtagca gagggtctga cctatcgtac ccctcaagta     4080

gctatggctg ctggggatca ggtgatgaca gcagaatatt gggtgcggca ggttcgggac     4140

acagttcgct tcggggagca agtagcgtca ttcgaggatg cggtgtttgt tgagttaggc     4200

gctgacagaa gtctagcgcg tttggtggac ggcatcgcca tgctgcacgg tgaccacgaa     4260

gcgcaggccg cggaccatag gcaaatcacc gaagcggttg cggatgctta cgtcttaggc     4320

caccttccgg attttgcggc gctgcggcgg cctcacgcac gaaagttgga cttaccaact     4380

tatcccttcg agcgtagaca gtactggttc agagatgcgc gtgagaggcc ggaacaaccc     4440

agagataccg gcggacctcg cacagaagca gtccgtctgt tagaggatgg taggattgaa     4500

gaattagctg cacttttggg aggggccagt gatgaccaac acacattaca ggtgctgact     4560

aagttggcgg cgcaacataa ccaacaacga acaacccggt caatcgctga cgacaggtac     4620

gaaataaggt gggaccgatc gacttcccca ctatccggag cagatgttga ccaagcgggg     4680

agctggatcg tggtgtcaga tgacgcagat gccgttcccc cgctagtgga cttgctggct     4740

gcacgtaacg agccccatca ggttgttggt ctacccgctt cggacgcaga cgaggagagg     4800

ctcgcagaga ctctgcgtgc ggctgcgact gaagatgcta cccttcggat agtccacgtt     4860

gcggcgctcg aagcaggcgc tacccccagc atgcgttcac tgctccgcat gcagcaccga     4920

atactaggtg gcacgcggcg ggtgttcagg gcagcggtcg cagcggagtt aagaggtccc     4980

atttggatag tgacgcgggg agcacaaaga gtggctgaca ccgatacagt tgccccgcat     5040

cagtcatgcc tctggggatt tgggagggca gcatcgctgg agctgccgca cgtttggggt     5100

ggcctagcag atttatcaga gggcggtgac aatgcggccg atgagtggag tgcgctagtg     5160

gaccgcattg ccgcacccca cggttcagca gttagggagg accaactggc gctgagagac     5220

agggccgtat atacgccaag actggccaga cgttctgcgc ccccgagcgg gactccccta     5280

catctacgag gggatggcac agtgttaata acaggtggga ctggtacact aggtaggcta     5340

ttagcgcgtc acctagtaac agagcatggg gtgcggcatc tcttactagt ttcaaggaga     5400

ggcgccgatg cccctggctc ggatgaactg cgcgcagaaa tagaggactt aggtgccagc     5460

gcggagatcg cagcgtgtga tacagcggat cgcgatgccc tatctgccct actagatggt     5520

ctcccccggc cccttacggg tgtcgttcac gccgctggcg tgttagccga tggacttgtc     5580

actagcattg acgagcctgc ggtggaacag gttctccgag caaaggtgga cgcggcatgg     5640

aacctacacg aactcacagc taataccggg ctatcctttt tcgttctttt ctcatcagca     5700

gcatcggtcc tggcaggtcc agggcaagga gtttatgcgg ctgcaaatga atcgctcaac     5760

gcactagctg cgttaaggcg aactaggggt ctgccggcca aggctctggg atggggcctg     5820

tgggccatcg ggcgggcaat cgcttttgcg gagcagaccg gggacgccat cgctccagag     5880

gaaggagcat acgcttttga aactctgtta aggcataacc gtgcctactc gggatatgcg     5940

cccgtcattg gatctccctg gttgaccgcg ttcgcacagc attccccctt tgcagaaaaa     6000

ttccaatcac tcggacagaa tcggtcaggg acatcgaaat tcttagcgga gctagttgac     6060

ctgcctcgtg aggaatggcc ggataggctc aggagactac tagagttagt taggtcccat     6120

gccgccgcgg tctccggtta cggtagtgca gatcaactgc cggaaagaaa agcgttcaag     6180

gatttggggt ttgattcgct ggccgccgtt gaactgcgta accggctggg aacggctaca     6240

ggggtacgac tgccgtcaac cctagtattt gatcacccaa ctccgctggc cgtcgctgag     6300

cacttaagag ataggctatt ggcttccgct cgtgctccgc gtgacgtccg ccaaacagct     6360

cacgctgacg ctgctgaacc ggctggcgac gacggccttc agcacttgcc cttagtagct     6420

gcgcaacctg gaatatggat ggccgagaag ttatctgaac taccatcagc gtggagcgta     6480

gcgcattacg tggagctcac tggtgaggtt gactcgcctc ttttggccag ggcggtagtg     6540

gctggccttg cacaagctga caccttaaga atgcgtttca cagaggataa tggggaagtt     6600

tggcaatggg tagacgatgc gttaacattt gagttaccgg aaatcataga cctgcgcact     6660

aacatagacc ctcacgggac agctcaggcc ttgatgcaag cggacctgca acaggaccta     6720

cgtgtggatt cggggaagcc tctggtcttc catcagctaa ttcaagtagc ggacaatcgc     6780

tggtactggt atcaaaggta ccaccacttg cttgtggacg ggttcagttt tccagcgata     6840

accaggcaaa tagccaacat ttattgcact tggttgcgag gagagcctac gcccgcatcc     6900

cccttcacgc cattcgcaga cgttgttgag gaataccaac agtatcgcga gagcgaagcg     6960

tggcaacgcg atgcggcatt ctgggcggag caacgacggc aactaccgcc tcccgcatcc     7020

ctatcacctg ccccgctccc cggccggtcc gcgtcagccg acattctacg gctaaagctg     7080

gagttcacag atggtgaatt tcgacagctt gctacacaac tcagcggggt acaaaggaca     7140

gacctagcgc tcgctctggc tgcattatgg ctaggacgac tttgcaatcg aatggactac     7200

gcggcgggtt tcatatttat gcgccggctc ggcagcgcag cgttgaccgc aacgggtcca     7260

gttttaaatg ttcttccttt gggaatccac ataggcaacc caagcttctc tgagcttctc     7320

accagggttc gcgaggtcgc cttaggcgcg tatgcacacc aacatattcc ttttgagatg     7380

ttagtagagg cactgcaacc agagcgaaac cttagccata ctcctctctt ccaagtgatg     7440

tttgtccttc agaatgcgcc cgcgtcccaa ttagagttaa ccgggatcac cgcaaaccca     7500

attaaggtta aatcaactac cacgaagttc gacctaactt taatcatgca aaacacagct     7560

agcggattag taggtgtttg ggagtacaac acggatttat tcgacgcgtc aacgattgag     7620

cgaatgacag ggcactttgt aaccctcctc gagggcgtta tcgccaatcc acaacagccg     7680

atctctcaac ttcctatttt aactacagtg gagcaacagc aacttttagt cgagtggaat     7740

aacacgcaaa ccgactaccc cgctgataag tgtatacatc aattattcga ggaacaggtc     7800

gagcgcacac cagacgccgt tgctgtcgtc tttgggaatc agcaactcag ctatcgagag     7860

atgcgcgaac aagtggttgc actcgccaat ttattacgtg agcggggagt caagccagga     7920

gactccgttg ccgtggcctt accacgctct gttttcttaa cccttgcact acacgcgatt     7980

gtcgaggcag gtgccgcctg gctacctctt gacacaggat atcctgacga tagattaaaa     8040

atgatgctcg aggatgcacg gccttccctt ctgatcacaa cagacgatca attaccccgc     8100

ttcagtgacg tacctaatct gacctcactc tgttacaacg ctcccttgac gcctcaaggg     8160

agcgcccctt tacagctgtc tcaacctcac catactgcat atatcatctt tacaagtggt     8220

tctacgggac gccccaaggg agtaatggtt ggtcagactg cgattgtaaa tcgtctgttg     8280

tggatgcaaa accactaccc tttgacgggg gaggacgttg tagcccaaaa gactccttgc     8340

tcgttcgatg tctcagtctg ggagttcttt tggccattta tagcaggggc caaattagtt     8400

atggcggagc cggaagccca ccgagaccca cttgcgatgc agcaattctt tgctgagtat     8460

ggtgtcacca ctacacattt cgtcccatcg atgttagcgg ccttcgtggc ttctcttact     8520

ccacaaacgg ctaggcaatc ttgtgccaca ctaaagcaag tcttctgctc cggcgaggca     8580

ttacctgcag acttgtgccg ggaatggcag caactcacag gagctccatt gcacaatcta     8640

tacggaccga ccgaggccgc agtagacgta tcttggtatc ctgcgtttgg cgaggagtta     8700

gcgcaagtaa gaggttcgtc agtaccaata ggataccccg tatggaacac ggggcttcgg     8760

atactggacg cgatgatgca tccggtccca ccaggagtcg cgggcgattt atacctgact     8820

gggatacagc tggcccaagg ttacctaggg agacctgacc ttacggcgtc gaggttcata     8880

gcggatccgt ttgctccggg tgagcgcatg taccgtacgg gcgacgtcgc gcgatggcta     8940

gataatggcg ccgtagagta tcttggtaga tcagacgatc agttaaagat acggggacaa     9000

cgaatagagc ttggggaaat agaccgggta atgcaggctt tgccagatgt cgagcaagcg     9060

gtggcttcgt gtgctattgc gcgggaggac atacctggga acaaacacct tgtagcgtac     9120

atagttcctc aagaggagca aacatgcact gagcgatcga ggtccacact tacagtttcg     9180

ttcgtccgga gtttccttaa ggagaaactc cccgaatata tggtaccgag cgcaatagtg     9240

attctagacg ctctccccct gactcctaat ggaaagctag accggcgggc gttacccgcc     9300

cctgacctgc actcacaact tgagacaatt attgctgcgg ctttctcgag cctgctcggg     9360

tgcgacgtac aagacgcgga tgctgacttt ttcgcgctag gtggccattc gctgcttgcc     9420

atgaagctag ccgctcagct ttcccgacaa gtagcgcggc aggtgacacc aggccaagtt     9480

atggtagctt cgactgtcgc aaagctcgca acgatcatag acgcggagtt agataaatac     9540

gtcgctccaa ggaacccgat aacatccggg gaagataacc ctatccccct atgtcaaggc     9600

gatggggagg agatgagcac atggctacgt cgttttggac ccccagtcga acatcgggcc     9660

aggctagtgt gtttccccca cgcaggcgca gcggcggatt catacttaga cctagcaaga     9720

gcgttagcac cagagatcga tgttcatgct gttcaatacc ccggcaggca agacagaagg     9780

gacgaggagc cattaggaac cgcaggtgaa attgcagatg aagtggcagc ggtgctacgt     9840

gcgtcgggag gggatgggcc ttttgcactt ttcggccaca gtatgggcgc cctcatcgcg     9900

tacgagacag caaggcgatt agagagggaa ccgggagggg gacccttacg tttattcgtg     9960

agcggacaaa cagcgccacg tgtccatgaa cgaagaactg atctgcccgg tgacgatgga    10020

ctcgtggacg agcttaggcg acttggcacc tccgaggcag cgctcgcaga cgaagccctg    10080

ctggctatgt ctctcccggt gctcagggcg gattataggg tgttaagatc ctacgcttgg    10140

gcggatggtc ccccactacg cgccggtata actgccctct gcggtgatgc agacccacta    10200

actgcaacag gggatgcgga acgctggtta caacattccg tgattccggg tcggacacgg    10260

acatttcccg gtgggcattt ttatttaggg gaacaagtga ccgaggtggc aggggctgtc    10320

cgtagagatt tactgagagc agggttagcg ggttga                              10356


<210>  139
<211>  3451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalOH-Ser

<400>  139

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Ala Asp  His Arg Gln 
    1415                 1420                 1425             


Ile Thr  Glu Ala Val Ala Asp  Ala Tyr Val Leu Gly  His Leu Pro 
    1430                 1435                 1440             


Asp Phe  Ala Ala Leu Arg Arg  Pro His Ala Arg Lys  Leu Asp Leu 
    1445                 1450                 1455             


Pro Thr  Tyr Pro Phe Glu Arg  Arg Gln Tyr Trp Phe  Arg Asp Ala 
    1460                 1465                 1470             


Arg Glu  Arg Pro Glu Gln Pro  Arg Asp Thr Gly Gly  Pro Arg Thr 
    1475                 1480                 1485             


Glu Ala  Val Arg Leu Leu Glu  Asp Gly Arg Ile Glu  Glu Leu Ala 
    1490                 1495                 1500             


Ala Leu  Leu Gly Gly Ala Ser  Asp Asp Gln His Thr  Leu Gln Val 
    1505                 1510                 1515             


Leu Thr  Lys Leu Ala Ala Gln  His Asn Gln Gln Arg  Thr Thr Arg 
    1520                 1525                 1530             


Ser Ile  Ala Asp Asp Arg Tyr  Glu Ile Arg Trp Asp  Arg Ser Thr 
    1535                 1540                 1545             


Ser Pro  Leu Ser Gly Ala Asp  Val Asp Gln Ala Gly  Ser Trp Ile 
    1550                 1555                 1560             


Val Val  Ser Asp Asp Ala Asp  Ala Val Pro Pro Leu  Val Asp Leu 
    1565                 1570                 1575             


Leu Ala  Ala Arg Asn Glu Pro  His Gln Val Val Gly  Leu Pro Ala 
    1580                 1585                 1590             


Ser Asp  Ala Asp Glu Glu Arg  Leu Ala Glu Thr Leu  Arg Ala Ala 
    1595                 1600                 1605             


Ala Thr  Glu Asp Ala Thr Leu  Arg Ile Val His Val  Ala Ala Leu 
    1610                 1615                 1620             


Glu Ala  Gly Ala Thr Pro Ser  Met Arg Ser Leu Leu  Arg Met Gln 
    1625                 1630                 1635             


His Arg  Ile Leu Gly Gly Thr  Arg Arg Val Phe Arg  Ala Ala Val 
    1640                 1645                 1650             


Ala Ala  Glu Leu Arg Gly Pro  Ile Trp Ile Val Thr  Arg Gly Ala 
    1655                 1660                 1665             


Gln Arg  Val Ala Asp Thr Asp  Thr Val Ala Pro His  Gln Ser Cys 
    1670                 1675                 1680             


Leu Trp  Gly Phe Gly Arg Ala  Ala Ser Leu Glu Leu  Pro His Val 
    1685                 1690                 1695             


Trp Gly  Gly Leu Ala Asp Leu  Ser Glu Gly Gly Asp  Asn Ala Ala 
    1700                 1705                 1710             


Asp Glu  Trp Ser Ala Leu Val  Asp Arg Ile Ala Ala  Pro His Gly 
    1715                 1720                 1725             


Ser Ala  Val Arg Glu Asp Gln  Leu Ala Leu Arg Asp  Arg Ala Val 
    1730                 1735                 1740             


Tyr Thr  Pro Arg Leu Ala Arg  Arg Ser Ala Pro Pro  Ser Gly Thr 
    1745                 1750                 1755             


Pro Leu  His Leu Arg Gly Asp  Gly Thr Val Leu Ile  Thr Gly Gly 
    1760                 1765                 1770             


Thr Gly  Thr Leu Gly Arg Leu  Leu Ala Arg His Leu  Val Thr Glu 
    1775                 1780                 1785             


His Gly  Val Arg His Leu Leu  Leu Val Ser Arg Arg  Gly Ala Asp 
    1790                 1795                 1800             


Ala Pro  Gly Ser Asp Glu Leu  Arg Ala Glu Ile Glu  Asp Leu Gly 
    1805                 1810                 1815             


Ala Ser  Ala Glu Ile Ala Ala  Cys Asp Thr Ala Asp  Arg Asp Ala 
    1820                 1825                 1830             


Leu Ser  Ala Leu Leu Asp Gly  Leu Pro Arg Pro Leu  Thr Gly Val 
    1835                 1840                 1845             


Val His  Ala Ala Gly Val Leu  Ala Asp Gly Leu Val  Thr Ser Ile 
    1850                 1855                 1860             


Asp Glu  Pro Ala Val Glu Gln  Val Leu Arg Ala Lys  Val Asp Ala 
    1865                 1870                 1875             


Ala Trp  Asn Leu His Glu Leu  Thr Ala Asn Thr Gly  Leu Ser Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Ala  Ala Ser Val Leu Ala  Gly Pro Gly 
    1895                 1900                 1905             


Gln Gly  Val Tyr Ala Ala Ala  Asn Glu Ser Leu Asn  Ala Leu Ala 
    1910                 1915                 1920             


Ala Leu  Arg Arg Thr Arg Gly  Leu Pro Ala Lys Ala  Leu Gly Trp 
    1925                 1930                 1935             


Gly Leu  Trp Ala Ile Gly Arg  Ala Ile Ala Phe Ala  Glu Gln Thr 
    1940                 1945                 1950             


Gly Asp  Ala Ile Ala Pro Glu  Glu Gly Ala Tyr Ala  Phe Glu Thr 
    1955                 1960                 1965             


Leu Leu  Arg His Asn Arg Ala  Tyr Ser Gly Tyr Ala  Pro Val Ile 
    1970                 1975                 1980             


Gly Ser  Pro Trp Leu Thr Ala  Phe Ala Gln His Ser  Pro Phe Ala 
    1985                 1990                 1995             


Glu Lys  Phe Gln Ser Leu Gly  Gln Asn Arg Ser Gly  Thr Ser Lys 
    2000                 2005                 2010             


Phe Leu  Ala Glu Leu Val Asp  Leu Pro Arg Glu Glu  Trp Pro Asp 
    2015                 2020                 2025             


Arg Leu  Arg Arg Leu Leu Glu  Leu Val Arg Ser His  Ala Ala Ala 
    2030                 2035                 2040             


Val Ser  Gly Tyr Gly Ser Ala  Asp Gln Leu Pro Glu  Arg Lys Ala 
    2045                 2050                 2055             


Phe Lys  Asp Leu Gly Phe Asp  Ser Leu Ala Ala Val  Glu Leu Arg 
    2060                 2065                 2070             


Asn Arg  Leu Gly Thr Ala Thr  Gly Val Arg Leu Pro  Ser Thr Leu 
    2075                 2080                 2085             


Val Phe  Asp His Pro Thr Pro  Leu Ala Val Ala Glu  His Leu Arg 
    2090                 2095                 2100             


Asp Arg  Leu Leu Ala Ser Ala  Arg Ala Pro Arg Asp  Val Arg Gln 
    2105                 2110                 2115             


Thr Ala  His Ala Asp Ala Ala  Glu Pro Ala Gly Asp  Asp Gly Leu 
    2120                 2125                 2130             


Gln His  Leu Pro Leu Val Ala  Ala Gln Pro Gly Ile  Trp Met Ala 
    2135                 2140                 2145             


Glu Lys  Leu Ser Glu Leu Pro  Ser Ala Trp Ser Val  Ala His Tyr 
    2150                 2155                 2160             


Val Glu  Leu Thr Gly Glu Val  Asp Ser Pro Leu Leu  Ala Arg Ala 
    2165                 2170                 2175             


Val Val  Ala Gly Leu Ala Gln  Ala Asp Thr Leu Arg  Met Arg Phe 
    2180                 2185                 2190             


Thr Glu  Asp Asn Gly Glu Val  Trp Gln Trp Val Asp  Asp Ala Leu 
    2195                 2200                 2205             


Thr Phe  Glu Leu Pro Glu Ile  Ile Asp Leu Arg Thr  Asn Ile Asp 
    2210                 2215                 2220             


Pro His  Gly Thr Ala Gln Ala  Leu Met Gln Ala Asp  Leu Gln Gln 
    2225                 2230                 2235             


Asp Leu  Arg Val Asp Ser Gly  Lys Pro Leu Val Phe  His Gln Leu 
    2240                 2245                 2250             


Ile Gln  Val Ala Asp Asn Arg  Trp Tyr Trp Tyr Gln  Arg Tyr His 
    2255                 2260                 2265             


His Leu  Leu Val Asp Gly Phe  Ser Phe Pro Ala Ile  Thr Arg Gln 
    2270                 2275                 2280             


Ile Ala  Asn Ile Tyr Cys Thr  Trp Leu Arg Gly Glu  Pro Thr Pro 
    2285                 2290                 2295             


Ala Ser  Pro Phe Thr Pro Phe  Ala Asp Val Val Glu  Glu Tyr Gln 
    2300                 2305                 2310             


Gln Tyr  Arg Glu Ser Glu Ala  Trp Gln Arg Asp Ala  Ala Phe Trp 
    2315                 2320                 2325             


Ala Glu  Gln Arg Arg Gln Leu  Pro Pro Pro Ala Ser  Leu Ser Pro 
    2330                 2335                 2340             


Ala Pro  Leu Pro Gly Arg Ser  Ala Ser Ala Asp Ile  Leu Arg Leu 
    2345                 2350                 2355             


Lys Leu  Glu Phe Thr Asp Gly  Glu Phe Arg Gln Leu  Ala Thr Gln 
    2360                 2365                 2370             


Leu Ser  Gly Val Gln Arg Thr  Asp Leu Ala Leu Ala  Leu Ala Ala 
    2375                 2380                 2385             


Leu Trp  Leu Gly Arg Leu Cys  Asn Arg Met Asp Tyr  Ala Ala Gly 
    2390                 2395                 2400             


Phe Ile  Phe Met Arg Arg Leu  Gly Ser Ala Ala Leu  Thr Ala Thr 
    2405                 2410                 2415             


Gly Pro  Val Leu Asn Val Leu  Pro Leu Gly Ile His  Ile Gly Asn 
    2420                 2425                 2430             


Pro Ser  Phe Ser Glu Leu Leu  Thr Arg Val Arg Glu  Val Ala Leu 
    2435                 2440                 2445             


Gly Ala  Tyr Ala His Gln His  Ile Pro Phe Glu Met  Leu Val Glu 
    2450                 2455                 2460             


Ala Leu  Gln Pro Glu Arg Asn  Leu Ser His Thr Pro  Leu Phe Gln 
    2465                 2470                 2475             


Val Met  Phe Val Leu Gln Asn  Ala Pro Ala Ser Gln  Leu Glu Leu 
    2480                 2485                 2490             


Thr Gly  Ile Thr Ala Asn Pro  Ile Lys Val Lys Ser  Thr Thr Thr 
    2495                 2500                 2505             


Lys Phe  Asp Leu Thr Leu Ile  Met Gln Asn Thr Ala  Ser Gly Leu 
    2510                 2515                 2520             


Val Gly  Val Trp Glu Tyr Asn  Thr Asp Leu Phe Asp  Ala Ser Thr 
    2525                 2530                 2535             


Ile Glu  Arg Met Thr Gly His  Phe Val Thr Leu Leu  Glu Gly Val 
    2540                 2545                 2550             


Ile Ala  Asn Pro Gln Gln Pro  Ile Ser Gln Leu Pro  Ile Leu Thr 
    2555                 2560                 2565             


Thr Val  Glu Gln Gln Gln Leu  Leu Val Glu Trp Asn  Asn Thr Gln 
    2570                 2575                 2580             


Thr Asp  Tyr Pro Ala Asp Lys  Cys Ile His Gln Leu  Phe Glu Glu 
    2585                 2590                 2595             


Gln Val  Glu Arg Thr Pro Asp  Ala Val Ala Val Val  Phe Gly Asn 
    2600                 2605                 2610             


Gln Gln  Leu Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    2615                 2620                 2625             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    2630                 2635                 2640             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    2645                 2650                 2655             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    2660                 2665                 2670             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    2675                 2680                 2685             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    2690                 2695                 2700             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    2705                 2710                 2715             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    2720                 2725                 2730             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    2735                 2740                 2745             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    2750                 2755                 2760             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    2765                 2770                 2775             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    2780                 2785                 2790             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    2795                 2800                 2805             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    2810                 2815                 2820             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    2825                 2830                 2835             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    2840                 2845                 2850             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    2855                 2860                 2865             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    2870                 2875                 2880             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    2885                 2890                 2895             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    2900                 2905                 2910             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    2915                 2920                 2925             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    2930                 2935                 2940             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    2945                 2950                 2955             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    2960                 2965                 2970             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    2975                 2980                 2985             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    2990                 2995                 3000             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    3005                 3010                 3015             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    3020                 3025                 3030             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    3035                 3040                 3045             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    3050                 3055                 3060             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    3065                 3070                 3075             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    3080                 3085                 3090             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Glu 
    3095                 3100                 3105             


Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val 
    3110                 3115                 3120             


Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu 
    3125                 3130                 3135             


Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg 
    3140                 3145                 3150             


Gln Val  Thr Pro Gly Gln Val  Met Val Ala Ser Thr  Val Ala Lys 
    3155                 3160                 3165             


Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Asp Lys Tyr  Val Ala Pro 
    3170                 3175                 3180             


Arg Asn  Pro Ile Thr Ser Gly  Glu Asp Asn Pro Ile  Pro Leu Cys 
    3185                 3190                 3195             


Gln Gly  Asp Gly Glu Glu Met  Ser Thr Trp Leu Arg  Arg Phe Gly 
    3200                 3205                 3210             


Pro Pro  Val Glu His Arg Ala  Arg Leu Val Cys Phe  Pro His Ala 
    3215                 3220                 3225             


Gly Ala  Ala Ala Asp Ser Tyr  Leu Asp Leu Ala Arg  Ala Leu Ala 
    3230                 3235                 3240             


Pro Glu  Ile Asp Val His Ala  Val Gln Tyr Pro Gly  Arg Gln Asp 
    3245                 3250                 3255             


Arg Arg  Asp Glu Glu Pro Leu  Gly Thr Ala Gly Glu  Ile Ala Asp 
    3260                 3265                 3270             


Glu Val  Ala Ala Val Leu Arg  Ala Ser Gly Gly Asp  Gly Pro Phe 
    3275                 3280                 3285             


Ala Leu  Phe Gly His Ser Met  Gly Ala Leu Ile Ala  Tyr Glu Thr 
    3290                 3295                 3300             


Ala Arg  Arg Leu Glu Arg Glu  Pro Gly Gly Gly Pro  Leu Arg Leu 
    3305                 3310                 3315             


Phe Val  Ser Gly Gln Thr Ala  Pro Arg Val His Glu  Arg Arg Thr 
    3320                 3325                 3330             


Asp Leu  Pro Gly Asp Asp Gly  Leu Val Asp Glu Leu  Arg Arg Leu 
    3335                 3340                 3345             


Gly Thr  Ser Glu Ala Ala Leu  Ala Asp Glu Ala Leu  Leu Ala Met 
    3350                 3355                 3360             


Ser Leu  Pro Val Leu Arg Ala  Asp Tyr Arg Val Leu  Arg Ser Tyr 
    3365                 3370                 3375             


Ala Trp  Ala Asp Gly Pro Pro  Leu Arg Ala Gly Ile  Thr Ala Leu 
    3380                 3385                 3390             


Cys Gly  Asp Ala Asp Pro Leu  Thr Ala Thr Gly Asp  Ala Glu Arg 
    3395                 3400                 3405             


Trp Leu  Gln His Ser Val Ile  Pro Gly Arg Thr Arg  Thr Phe Pro 
    3410                 3415                 3420             


Gly Gly  His Phe Tyr Leu Gly  Glu Gln Val Thr Glu  Val Ala Gly 
    3425                 3430                 3435             


Ala Val  Arg Arg Asp Leu Leu  Arg Ala Gly Leu Ala  Gly 
    3440                 3445                 3450     


<210>  140
<211>  12009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-Ser

<400>  140
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg gcctacccca ggaaattaaa     1860

cacacgccgg cggttcggac cacatccgaa gatccaattg ccatagtatc catggcttgc     1920

cggttacccg gtggtgtgaa taccccacag agactatggg aattattacg tgaaggggga     1980

gaaaccctca gtggcttccc taccgaccga gggtgggacc tcgcgaggtt gcatcaccca     2040

gacccagaca accccggtac gtcatacgtt gataaagggg gattcctgga cgatgcggca     2100

gggtttgacg cagaattttt cggtgtgagc cccagagaag cagcggctat ggacccgcag     2160

cagagattac tcctcgaaac cagctgggag ttagtcgaga atgcagggat tgatccacat     2220

agcctaaggg ggaccgccac tggtgtcttc ctcggcgttg ccaagtttgg gtatggcgag     2280

gatacggcag ctgccgaaga cgtcgagggg tactctgtca ctggtgtagc cccggcagtg     2340

gcgtcgggca gaattagtta cacgatgggg ttggaagggc cgtctatttc ggttgatacc     2400

gcctgttcct ccagtctggt tgcactccac cttgcagtcg agtcgctccg gaaaggagaa     2460

agcagtatgg ccgtggtcgg gggagcggcg gtgatggcca caccgggtgt gtttgtggat     2520

ttttcccgac agagagcctt ggccgcggat gggcgttcaa aggcgttcgg agcaggtgca     2580

gacgggtttg gatttagcga aggtgtgaca ctggttctcc tagaaagatt aagtgaagcc     2640

cggcgtaacg gccatgaggt gctggcagtt gttagaggtt ccgcattaaa ccaggacggg     2700

gcttcgaacg ggctgagcgc cccctcgggc ccggcacaga gaagagtgat acgccaagca     2760

ctcgaatcgt gtggcctaga accaggtgac gttgacgcgg tggaagcgca cgggacagga     2820

actgcgttag gggacccgat agaagcaaac gccttgctgg acacttatgg tagagatcgt     2880

gatgcggatc gacccctctg gttaggaagt gttaagtcaa atataggaca cactcaggca     2940

gcggcgggag taactgggct gctcaaagta gtcctagcct tacgcaatgg ggaactaccc     3000

gccaccctac atgtcgagga accgacaccg catgtggatt ggtcgagcgg gggagttgct     3060

ctcttggcgg gtaatcagcc gtggcgaaga ggtgaacgaa cccgtagagc cgccgtgtcc     3120

gcattcggga tcagtggtac gaacgcgcac gtgattgtgg aagaagctcc acaagaggtg     3180

agaccagcgc ccggtcaagg actctcgccc gcggtgtcaa ccttggtagt ggcgggtaaa     3240

actatgcagc gtgtttcggc aaccgccggt atgctcgcag attggatgga aggcccaggt     3300

gcagatgtgg cgctggcgga cgtggcgcac acgttaaatc atcaccgttc acggcaacca     3360

aagttcggta cggtggtggc cagggaccgg acacaggcaa tcgccggact aagagcgctg     3420

gcggcgggtc agcacgcccc aggggttgtt aaccctgctg aaggaagtcc aggtccaggg     3480

acggtgttcg tgtttcctgg ccaggggtcc cagcgtgcag gcatggggga ggagttggct     3540

gcggctttcc ccgtgtttgc cagaatccac cagcaagtgt gggatttact cgatgttcct     3600

gatctcgacg ttaacgaaac ggggtacgca caaccagcac tcttcgcact ccaagtggcg     3660

ctgtttgggc tcctcgaatc atggggagta cggccggatg ccgtggtcgg gcatagtgta     3720

ggggaattag cggcagggta cgtttccggg ctttggagtc ttgaggatgc ttgcacgctc     3780

gtgtcggcga gagcccgtct aatgcaagcc ttaccggcag gtggtgttat ggcggcagtt     3840

ccagtgtccg aagacgaagc acgggctgtg ttgggggaag gagtcgaaat agctgcggtc     3900

aacggtccgt cgagcgtggt tctaagcggt gatgaagcag cagtgctcca ggccgcggaa     3960

gggttaggca agtggacgcg attaccgacc tcgcatgcat tccattctgc tcgtatggaa     4020

ccaatgctgg aagagtttag agcagtggcg gaaggtctaa catacaggac tccccaggtg     4080

gcaatggccg ccggagacca ggttatgacc gctgaatact gggtgcgtca ggttagggat     4140

acagttcgtt ttggcgagca agttgcctcg ttcgaggatg ctgtattcgt ggaattggga     4200

gcagatcgct ctcttgcacg gctagtcgat ggtatcgcga tgttgcacgg ggatcatgag     4260

gcacaggctg gtatgcggag agaacaaccc ttgcccttag gtttacgaag attgctaacc     4320

gacctgcata acgctggtgc tgccgtcgat tttagtgttt tgtgcccaca aggtcgtctg     4380

gttgacgcac cgttaccagc ctggtcacac cggtttctct tctatgaccg ggaaggagtg     4440

gacaatagat caccaggggg aagcacagtg gcggtccacc cgcttttact agccgcggtg     4500

gatgtgccgg gccacggtgg agcggttttc acgggtagac tctcgactga cgagcaaccg     4560

tggttagcgg agcacgttgt cgggggaaga accctagttc ctggttctgt tttagtcgat     4620

ctagccttag cggcaggcga agacgtaggg ctaccggtgt tagaagaatt agtattgcag     4680

aggccgctgg tgcttgccgg cgcgggagca ctcctacgga tgtcggtcgg ggcaccagac     4740

gagagcggta gaagaactat cgatgttcac gcagctgaag acgtcgccga tttagcagat     4800

gcccaatggt cccagcacgc caccgggact ttagcccaag gggtagcggc ggggcccagg     4860

gacacagagc aatggccccc agaggatgcc gtccggattc cattagacga ccattatgat     4920

ggtctcgcgg aacagggtta tgagtacggt ccgtcgtttc aggcgctagt ggcctacgtg     4980

gcggaggatg cgactgcgac aatgttagcg gaagtcgcgc ttccgggcag cattagatcg     5040

caacaaggtc tatacgccat ccatcccgca ctgctggacg cttgttttca atctgtcgga     5100

gcccacccag acagtcaatc cgtcgggtca ggtctactcg tacccctcgg tgttcggaga     5160

gttcgtgcgt acgcacccgt aaggaccgcc cgttattgtt acacccgcgt cacgaaagtt     5220

gaactagctg gggttgaggc cgacatcgac gttctggatg ctcacggcac agtgcttcta     5280

gccgtgtgcg gtcttcgtat cgggaccgga gtgagcgaga gggacaaaca caacagagtt     5340

ctcaatgagc gcctactcac catcgaatgg catcagcgtg aactaccaga aatggacccc     5400

tcgggtgccg ggaagtggct cctaatctcg gactgtgcag catccgatgt caccgctaca     5460

cgactggctg atgccttccg ggagcacagc gctgcgtgca ctaccatgcg gtggccactt     5520

cacgatgatc aactagcagc cgccgaccaa ctccgggacc aggtgggttc agatgagttt     5580

tctggcgtgg tagtactaac agggccaaac acagggaccc ctcatcaggg ttccgcagac     5640

cgtggcgccg agtacgttag gcggttagtt ggaatcgctc gtgaacttag cgatcttccc     5700

ggagcggttc cccgtatgta tgtcgtcaca aggggagcgc agagagtcct tgccgatgat     5760

tgtgttaatt tagaacaggg agggctcaga ggtctgctga ggaccatcgg tgctgagcac     5820

ccacatctcc gcgccaccca aattgatgtt gatgagcaga caggagtaga gcagctggcg     5880

cgacaactcc tagctacatc ggaggaagac gagacagcct ggagggacaa cgaatggtac     5940

gttgcgaggt tatgccccac acccctgagg ccacaggaac gtaggacaat agtggcggac     6000

catcaacagt ctggtatgcg gttacaaata cgtacgcccg gtgcaatcga tagtgtggcc     6060

tttgaacccg cacccgatgt agagcaaccc ttacgggcgg gtgaagttcg ggttgacgtt     6120

agagcaaccg gtgttaattt ccgtgacgtt ctactcgctc tcgggatgta tccccagaaa     6180

gctgacatgg ggacagaagc agctggtgtt gtaacagcag tgggacctga tgtcgatgcg     6240

tttgcgcctg gtgatagagt tctagggcta ttccaagggg catttgctcc aattgcggtg     6300

actgaccatc gtttactggc acgggtgcca gacgggtggt cagatgccga tgcggcggcg     6360

gtgccaatag cttacacgac agcacattat gcgctgcacg acctggcggg gttgcgggcg     6420

gggcaatctg tcctgataca cgcggcagcg ggtggtgttg gtatggccgc tgttgcactg     6480

gcacggaggg ccggcgcaga agttctggct accgcaggac ctgcaaaaca cggtacgcta     6540

cgggcattag ggctagatga tgaacacatc gcttcgagtc gggagaccgg gttcgcgcgt     6600

aagttccgag agcggactgg gggacgagga gtggacgtcg ttctaaacag cttgaccggc     6660

gaactattag acgagtccgc ggatctcctc gcggaggacg gagtcttcgt ggaaatggga     6720

aagactgatc tgcgcgatgc aggggacttt cgtgggcgct acgccccgtt tgatctaggg     6780

gaagcaggcg atgacaggct cggggaaatt ctacgtgagg tggtgggact gctcggtgca     6840

ggggaactcg accgactccc tgttagcgcg tgggaattgg ggatacccca gacggggaag     6900

tcgttagtga cgctgccacc cgaacaagcg caagttttca gaccagacgg cactgtattg     6960

atcaccgggg gaacgggaac gttaggtcgg ctgctggccc gtcatctggt tacagagcac     7020

ggggtgcgtc acctgctgct agtgtcgagg agaggagcag atgcccctgg atcggacgag     7080

ctgagggccg aaatcgagga tctcggagca tcagcggaaa ttgcagcatg tgatacagcc     7140

gatcgagacg ctctcagcgc gttgctagat ggactgccga ggccactgac cggagtagtt     7200

cacgccgcgg gagtcctcgc tgacggtctg gttacatcca tcgacgagcc cgcagtcgaa     7260

caagttctcc gtgcaaaagt tgatgcggcc tggaacctgc acgagctaac tgcgaacacc     7320

ggtctcagct ttttcgtgct gttctcgtca gccgcaagtg tgttagcggg gccggggcag     7380

ggagtatatg cggcagcgaa cgaatcttta aacgctctgg ccgctctgcg taggactagg     7440

ggtttacccg caaaagcatt gggatgggga ttatgggcga tagggcgtgc aatagcattt     7500

gccgagcaga ccggtgacgc aatcgccccg gaggaaggcg cgtacgcctt cgagacacta     7560

ctcagacata acagggcgta ctcgggttac gctcccgtga tagggtcacc atggctgact     7620

gcgttcgccc aacattcgcc ctttgcggag aagttccagt ccctggggca aaatagatcc     7680

gggacgtcta agtttctggc agaattagtc gatctgccaa gagaagaatg gccagatcgg     7740

ttacgtcgtc tattagaact ggtgaggtct catgctgccg cagtttcggg gtatggatcg     7800

gcagaccaat taccagaaag aaaagcattc aaagacctcg gattcgattc actggcagca     7860

gtcgaactaa gaaatcgtct agggaccgcg acaggcgtcc ggctgcccag tactctggtg     7920

ttcgaccacc caaccccact tgcggttgcg gaacatctac gtgatcgtct attggcttcc     7980

gctcgtgctc cgcgtgacgt ccgccaaaca gctcacgctg acgctgctga accggctggc     8040

gacgacggcc ttcagcactt gcccttagta gctgcgcaac ctggaatatg gatggccgag     8100

aagttatctg aactaccatc agcgtggagc gtagcgcatt acgtggagct cactggtgag     8160

gttgactcgc ctcttttggc cagggcggta gtggctggcc ttgcacaagc tgacacctta     8220

agaatgcgtt tcacagagga taatggggaa gtttggcaat gggtagacga tgcgttaaca     8280

tttgagttac cggaaatcat agacctgcgc actaacatag accctcacgg gacagctcag     8340

gccttgatgc aagcggacct gcaacaggac ctacgtgtgg attcggggaa gcctctggtc     8400

ttccatcagc taattcaagt agcggacaat cgctggtact ggtatcaaag gtaccaccac     8460

ttgcttgtgg acgggttcag ttttccagcg ataaccaggc aaatagccaa catttattgc     8520

acttggttgc gaggagagcc tacgcccgca tcccccttca cgccattcgc agacgttgtt     8580

gaggaatacc aacagtatcg cgagagcgaa gcgtggcaac gcgatgcggc attctgggcg     8640

gagcaacgac ggcaactacc gcctcccgca tccctatcac ctgccccgct ccccggccgg     8700

tccgcgtcag ccgacattct acggctaaag ctggagttca cagatggtga atttcgacag     8760

cttgctacac aactcagcgg ggtacaaagg acagacctag cgctcgctct ggctgcatta     8820

tggctaggac gactttgcaa tcgaatggac tacgcggcgg gtttcatatt tatgcgccgg     8880

ctcggcagcg cagcgttgac cgcaacgggt ccagttttaa atgttcttcc tttgggaatc     8940

cacataggca acccaagctt ctctgagctt ctcaccaggg ttcgcgaggt cgccttaggc     9000

gcgtatgcac accaacatat tccttttgag atgttagtag aggcactgca accagagcga     9060

aaccttagcc atactcctct cttccaagtg atgtttgtcc ttcagaatgc gcccgcgtcc     9120

caattagagt taaccgggat caccgcaaac ccaattaagg ttaaatcaac taccacgaag     9180

ttcgacctaa ctttaatcat gcaaaacaca gctagcggat tagtaggtgt ttgggagtac     9240

aacacggatt tattcgacgc gtcaacgatt gagcgaatga cagggcactt tgtaaccctc     9300

ctcgagggcg ttatcgccaa tccacaacag ccgatctctc aacttcctat tttaactaca     9360

gtggagcaac agcaactttt agtcgagtgg aataacacgc aaaccgacta ccccgctgat     9420

aagtgtatac atcaattatt cgaggaacag gtcgagcgca caccagacgc cgttgctgtc     9480

gtctttggga atcagcaact cagctatcga gagatgcgcg aacaagtggt tgcactcgcc     9540

aatttattac gtgagcgggg agtcaagcca ggagactccg ttgccgtggc cttaccacgc     9600

tctgttttct taacccttgc actacacgcg attgtcgagg caggtgccgc ctggctacct     9660

cttgacacag gatatcctga cgatagatta aaaatgatgc tcgaggatgc acggccttcc     9720

cttctgatca caacagacga tcaattaccc cgcttcagtg acgtacctaa tctgacctca     9780

ctctgttaca acgctccctt gacgcctcaa gggagcgccc ctttacagct gtctcaacct     9840

caccatactg catatatcat ctttacaagt ggttctacgg gacgccccaa gggagtaatg     9900

gttggtcaga ctgcgattgt aaatcgtctg ttgtggatgc aaaaccacta ccctttgacg     9960

ggggaggacg ttgtagccca aaagactcct tgctcgttcg atgtctcagt ctgggagttc    10020

ttttggccat ttatagcagg ggccaaatta gttatggcgg agccggaagc ccaccgagac    10080

ccacttgcga tgcagcaatt ctttgctgag tatggtgtca ccactacaca tttcgtccca    10140

tcgatgttag cggccttcgt ggcttctctt actccacaaa cggctaggca atcttgtgcc    10200

acactaaagc aagtcttctg ctccggcgag gcattacctg cagacttgtg ccgggaatgg    10260

cagcaactca caggagctcc attgcacaat ctatacggac cgaccgaggc cgcagtagac    10320

gtatcttggt atcctgcgtt tggcgaggag ttagcgcaag taagaggttc gtcagtacca    10380

ataggatacc ccgtatggaa cacggggctt cggatactgg acgcgatgat gcatccggtc    10440

ccaccaggag tcgcgggcga tttatacctg actgggatac agctggccca aggttaccta    10500

gggagacctg accttacggc gtcgaggttc atagcggatc cgtttgctcc gggtgagcgc    10560

atgtaccgta cgggcgacgt cgcgcgatgg ctagataatg gcgccgtaga gtatcttggt    10620

agatcagacg atcagttaaa gatacgggga caacgaatag agcttgggga aatagaccgg    10680

gtaatgcagg ctttgccaga tgtcgagcaa gcggtggctt cgtgtgctat tgcgcgggag    10740

gacatacctg ggaacaaaca ccttgtagcg tacatagttc ctcaagagga gcaaacatgc    10800

actgagcgat cgaggtccac acttacagtt tcgttcgtcc ggagtttcct taaggagaaa    10860

ctccccgaat atatggtacc gagcgcaata gtgattctag acgctctccc cctgactcct    10920

aatggaaagc tagaccggcg ggcgttaccc gcccctgacc tgcactcaca acttgagaca    10980

attattgctg cggctttctc gagcctgctc gggtgcgacg tacaagacgc ggatgctgac    11040

tttttcgcgc taggtggcca ttcgctgctt gccatgaagc tagccgctca gctttcccga    11100

caagtagcgc ggcaggtgac accaggccaa gttatggtag cttcgactgt cgcaaagctc    11160

gcaacgatca tagacgcgga gttagataaa tacgtcgctc caaggaaccc gataacatcc    11220

ggggaagata accctatccc cctatgtcaa ggcgatgggg aggagatgag cacatggcta    11280

cgtcgttttg gacccccagt cgaacatcgg gccaggctag tgtgtttccc ccacgcaggc    11340

gcagcggcgg attcatactt agacctagca agagcgttag caccagagat cgatgttcat    11400

gctgttcaat accccggcag gcaagacaga agggacgagg agccattagg aaccgcaggt    11460

gaaattgcag atgaagtggc agcggtgcta cgtgcgtcgg gaggggatgg gccttttgca    11520

cttttcggcc acagtatggg cgccctcatc gcgtacgaga cagcaaggcg attagagagg    11580

gaaccgggag ggggaccctt acgtttattc gtgagcggac aaacagcgcc acgtgtccat    11640

gaacgaagaa ctgatctgcc cggtgacgat ggactcgtgg acgagcttag gcgacttggc    11700

acctccgagg cagcgctcgc agacgaagcc ctgctggcta tgtctctccc ggtgctcagg    11760

gcggattata gggtgttaag atcctacgct tgggcggatg gtcccccact acgcgccggt    11820

ataactgccc tctgcggtga tgcagaccca ctaactgcaa caggggatgc ggaacgctgg    11880

ttacaacatt ccgtgattcc gggtcggaca cggacatttc ccggtgggca tttttattta    11940

ggggaacaag tgaccgaggt ggcaggggct gtccgtagag atttactgag agcagggtta    12000

gcgggttga                                                            12009


<210>  141
<211>  4002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-MalH-Ser

<400>  141

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Gly Leu Pro Gln Glu Ile Lys His Thr Pro Ala 
    610                 615                 620                 


Val Arg Thr Thr Ser Glu Asp Pro Ile Ala Ile Val Ser Met Ala Cys 
625                 630                 635                 640 


Arg Leu Pro Gly Gly Val Asn Thr Pro Gln Arg Leu Trp Glu Leu Leu 
                645                 650                 655     


Arg Glu Gly Gly Glu Thr Leu Ser Gly Phe Pro Thr Asp Arg Gly Trp 
            660                 665                 670         


Asp Leu Ala Arg Leu His His Pro Asp Pro Asp Asn Pro Gly Thr Ser 
        675                 680                 685             


Tyr Val Asp Lys Gly Gly Phe Leu Asp Asp Ala Ala Gly Phe Asp Ala 
    690                 695                 700                 


Glu Phe Phe Gly Val Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln 
705                 710                 715                 720 


Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Leu Val Glu Asn Ala Gly 
                725                 730                 735     


Ile Asp Pro His Ser Leu Arg Gly Thr Ala Thr Gly Val Phe Leu Gly 
            740                 745                 750         


Val Ala Lys Phe Gly Tyr Gly Glu Asp Thr Ala Ala Ala Glu Asp Val 
        755                 760                 765             


Glu Gly Tyr Ser Val Thr Gly Val Ala Pro Ala Val Ala Ser Gly Arg 
    770                 775                 780                 


Ile Ser Tyr Thr Met Gly Leu Glu Gly Pro Ser Ile Ser Val Asp Thr 
785                 790                 795                 800 


Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Glu Ser Leu 
                805                 810                 815     


Arg Lys Gly Glu Ser Ser Met Ala Val Val Gly Gly Ala Ala Val Met 
            820                 825                 830         


Ala Thr Pro Gly Val Phe Val Asp Phe Ser Arg Gln Arg Ala Leu Ala 
        835                 840                 845             


Ala Asp Gly Arg Ser Lys Ala Phe Gly Ala Gly Ala Asp Gly Phe Gly 
    850                 855                 860                 


Phe Ser Glu Gly Val Thr Leu Val Leu Leu Glu Arg Leu Ser Glu Ala 
865                 870                 875                 880 


Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Leu 
                885                 890                 895     


Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Ser Gly Pro Ala 
            900                 905                 910         


Gln Arg Arg Val Ile Arg Gln Ala Leu Glu Ser Cys Gly Leu Glu Pro 
        915                 920                 925             


Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly 
    930                 935                 940                 


Asp Pro Ile Glu Ala Asn Ala Leu Leu Asp Thr Tyr Gly Arg Asp Arg 
945                 950                 955                 960 


Asp Ala Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn Ile Gly 
                965                 970                 975     


His Thr Gln Ala Ala Ala Gly Val Thr Gly Leu Leu Lys Val Val Leu 
            980                 985                 990         


Ala Leu Arg Asn Gly Glu Leu Pro  Ala Thr Leu His Val  Glu Glu Pro 
        995                 1000                 1005             


Thr Pro  His Val Asp Trp Ser  Ser Gly Gly Val Ala  Leu Leu Ala 
    1010                 1015                 1020             


Gly Asn  Gln Pro Trp Arg Arg  Gly Glu Arg Thr Arg  Arg Ala Ala 
    1025                 1030                 1035             


Val Ser  Ala Phe Gly Ile Ser  Gly Thr Asn Ala His  Val Ile Val 
    1040                 1045                 1050             


Glu Glu  Ala Pro Gln Glu Val  Arg Pro Ala Pro Gly  Gln Gly Leu 
    1055                 1060                 1065             


Ser Pro  Ala Val Ser Thr Leu  Val Val Ala Gly Lys  Thr Met Gln 
    1070                 1075                 1080             


Arg Val  Ser Ala Thr Ala Gly  Met Leu Ala Asp Trp  Met Glu Gly 
    1085                 1090                 1095             


Pro Gly  Ala Asp Val Ala Leu  Ala Asp Val Ala His  Thr Leu Asn 
    1100                 1105                 1110             


His His  Arg Ser Arg Gln Pro  Lys Phe Gly Thr Val  Val Ala Arg 
    1115                 1120                 1125             


Asp Arg  Thr Gln Ala Ile Ala  Gly Leu Arg Ala Leu  Ala Ala Gly 
    1130                 1135                 1140             


Gln His  Ala Pro Gly Val Val  Asn Pro Ala Glu Gly  Ser Pro Gly 
    1145                 1150                 1155             


Pro Gly  Thr Val Phe Val Phe  Pro Gly Gln Gly Ser  Gln Arg Ala 
    1160                 1165                 1170             


Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe Pro Val  Phe Ala Arg 
    1175                 1180                 1185             


Ile His  Gln Gln Val Trp Asp  Leu Leu Asp Val Pro  Asp Leu Asp 
    1190                 1195                 1200             


Val Asn  Glu Thr Gly Tyr Ala  Gln Pro Ala Leu Phe  Ala Leu Gln 
    1205                 1210                 1215             


Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp Gly Val  Arg Pro Asp 
    1220                 1225                 1230             


Ala Val  Val Gly His Ser Val  Gly Glu Leu Ala Ala  Gly Tyr Val 
    1235                 1240                 1245             


Ser Gly  Leu Trp Ser Leu Glu  Asp Ala Cys Thr Leu  Val Ser Ala 
    1250                 1255                 1260             


Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala Gly Gly  Val Met Ala 
    1265                 1270                 1275             


Ala Val  Pro Val Ser Glu Asp  Glu Ala Arg Ala Val  Leu Gly Glu 
    1280                 1285                 1290             


Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro Ser Ser  Val Val Leu 
    1295                 1300                 1305             


Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ala Ala Glu  Gly Leu Gly 
    1310                 1315                 1320             


Lys Trp  Thr Arg Leu Pro Thr  Ser His Ala Phe His  Ser Ala Arg 
    1325                 1330                 1335             


Met Glu  Pro Met Leu Glu Glu  Phe Arg Ala Val Ala  Glu Gly Leu 
    1340                 1345                 1350             


Thr Tyr  Arg Thr Pro Gln Val  Ala Met Ala Ala Gly  Asp Gln Val 
    1355                 1360                 1365             


Met Thr  Ala Glu Tyr Trp Val  Arg Gln Val Arg Asp  Thr Val Arg 
    1370                 1375                 1380             


Phe Gly  Glu Gln Val Ala Ser  Phe Glu Asp Ala Val  Phe Val Glu 
    1385                 1390                 1395             


Leu Gly  Ala Asp Arg Ser Leu  Ala Arg Leu Val Asp  Gly Ile Ala 
    1400                 1405                 1410             


Met Leu  His Gly Asp His Glu  Ala Gln Ala Gly Met  Arg Arg Glu 
    1415                 1420                 1425             


Gln Pro  Leu Pro Leu Gly Leu  Arg Arg Leu Leu Thr  Asp Leu His 
    1430                 1435                 1440             


Asn Ala  Gly Ala Ala Val Asp  Phe Ser Val Leu Cys  Pro Gln Gly 
    1445                 1450                 1455             


Arg Leu  Val Asp Ala Pro Leu  Pro Ala Trp Ser His  Arg Phe Leu 
    1460                 1465                 1470             


Phe Tyr  Asp Arg Glu Gly Val  Asp Asn Arg Ser Pro  Gly Gly Ser 
    1475                 1480                 1485             


Thr Val  Ala Val His Pro Leu  Leu Leu Ala Ala Val  Asp Val Pro 
    1490                 1495                 1500             


Gly His  Gly Gly Ala Val Phe  Thr Gly Arg Leu Ser  Thr Asp Glu 
    1505                 1510                 1515             


Gln Pro  Trp Leu Ala Glu His  Val Val Gly Gly Arg  Thr Leu Val 
    1520                 1525                 1530             


Pro Gly  Ser Val Leu Val Asp  Leu Ala Leu Ala Ala  Gly Glu Asp 
    1535                 1540                 1545             


Val Gly  Leu Pro Val Leu Glu  Glu Leu Val Leu Gln  Arg Pro Leu 
    1550                 1555                 1560             


Val Leu  Ala Gly Ala Gly Ala  Leu Leu Arg Met Ser  Val Gly Ala 
    1565                 1570                 1575             


Pro Asp  Glu Ser Gly Arg Arg  Thr Ile Asp Val His  Ala Ala Glu 
    1580                 1585                 1590             


Asp Val  Ala Asp Leu Ala Asp  Ala Gln Trp Ser Gln  His Ala Thr 
    1595                 1600                 1605             


Gly Thr  Leu Ala Gln Gly Val  Ala Ala Gly Pro Arg  Asp Thr Glu 
    1610                 1615                 1620             


Gln Trp  Pro Pro Glu Asp Ala  Val Arg Ile Pro Leu  Asp Asp His 
    1625                 1630                 1635             


Tyr Asp  Gly Leu Ala Glu Gln  Gly Tyr Glu Tyr Gly  Pro Ser Phe 
    1640                 1645                 1650             


Gln Ala  Leu Val Ala Tyr Val  Ala Glu Asp Ala Thr  Ala Thr Met 
    1655                 1660                 1665             


Leu Ala  Glu Val Ala Leu Pro  Gly Ser Ile Arg Ser  Gln Gln Gly 
    1670                 1675                 1680             


Leu Tyr  Ala Ile His Pro Ala  Leu Leu Asp Ala Cys  Phe Gln Ser 
    1685                 1690                 1695             


Val Gly  Ala His Pro Asp Ser  Gln Ser Val Gly Ser  Gly Leu Leu 
    1700                 1705                 1710             


Val Pro  Leu Gly Val Arg Arg  Val Arg Ala Tyr Ala  Pro Val Arg 
    1715                 1720                 1725             


Thr Ala  Arg Tyr Cys Tyr Thr  Arg Val Thr Lys Val  Glu Leu Ala 
    1730                 1735                 1740             


Gly Val  Glu Ala Asp Ile Asp  Val Leu Asp Ala His  Gly Thr Val 
    1745                 1750                 1755             


Leu Leu  Ala Val Cys Gly Leu  Arg Ile Gly Thr Gly  Val Ser Glu 
    1760                 1765                 1770             


Arg Asp  Lys His Asn Arg Val  Leu Asn Glu Arg Leu  Leu Thr Ile 
    1775                 1780                 1785             


Glu Trp  His Gln Arg Glu Leu  Pro Glu Met Asp Pro  Ser Gly Ala 
    1790                 1795                 1800             


Gly Lys  Trp Leu Leu Ile Ser  Asp Cys Ala Ala Ser  Asp Val Thr 
    1805                 1810                 1815             


Ala Thr  Arg Leu Ala Asp Ala  Phe Arg Glu His Ser  Ala Ala Cys 
    1820                 1825                 1830             


Thr Thr  Met Arg Trp Pro Leu  His Asp Asp Gln Leu  Ala Ala Ala 
    1835                 1840                 1845             


Asp Gln  Leu Arg Asp Gln Val  Gly Ser Asp Glu Phe  Ser Gly Val 
    1850                 1855                 1860             


Val Val  Leu Thr Gly Pro Asn  Thr Gly Thr Pro His  Gln Gly Ser 
    1865                 1870                 1875             


Ala Asp  Arg Gly Ala Glu Tyr  Val Arg Arg Leu Val  Gly Ile Ala 
    1880                 1885                 1890             


Arg Glu  Leu Ser Asp Leu Pro  Gly Ala Val Pro Arg  Met Tyr Val 
    1895                 1900                 1905             


Val Thr  Arg Gly Ala Gln Arg  Val Leu Ala Asp Asp  Cys Val Asn 
    1910                 1915                 1920             


Leu Glu  Gln Gly Gly Leu Arg  Gly Leu Leu Arg Thr  Ile Gly Ala 
    1925                 1930                 1935             


Glu His  Pro His Leu Arg Ala  Thr Gln Ile Asp Val  Asp Glu Gln 
    1940                 1945                 1950             


Thr Gly  Val Glu Gln Leu Ala  Arg Gln Leu Leu Ala  Thr Ser Glu 
    1955                 1960                 1965             


Glu Asp  Glu Thr Ala Trp Arg  Asp Asn Glu Trp Tyr  Val Ala Arg 
    1970                 1975                 1980             


Leu Cys  Pro Thr Pro Leu Arg  Pro Gln Glu Arg Arg  Thr Ile Val 
    1985                 1990                 1995             


Ala Asp  His Gln Gln Ser Gly  Met Arg Leu Gln Ile  Arg Thr Pro 
    2000                 2005                 2010             


Gly Ala  Ile Asp Ser Val Ala  Phe Glu Pro Ala Pro  Asp Val Glu 
    2015                 2020                 2025             


Gln Pro  Leu Arg Ala Gly Glu  Val Arg Val Asp Val  Arg Ala Thr 
    2030                 2035                 2040             


Gly Val  Asn Phe Arg Asp Val  Leu Leu Ala Leu Gly  Met Tyr Pro 
    2045                 2050                 2055             


Gln Lys  Ala Asp Met Gly Thr  Glu Ala Ala Gly Val  Val Thr Ala 
    2060                 2065                 2070             


Val Gly  Pro Asp Val Asp Ala  Phe Ala Pro Gly Asp  Arg Val Leu 
    2075                 2080                 2085             


Gly Leu  Phe Gln Gly Ala Phe  Ala Pro Ile Ala Val  Thr Asp His 
    2090                 2095                 2100             


Arg Leu  Leu Ala Arg Val Pro  Asp Gly Trp Ser Asp  Ala Asp Ala 
    2105                 2110                 2115             


Ala Ala  Val Pro Ile Ala Tyr  Thr Thr Ala His Tyr  Ala Leu His 
    2120                 2125                 2130             


Asp Leu  Ala Gly Leu Arg Ala  Gly Gln Ser Val Leu  Ile His Ala 
    2135                 2140                 2145             


Ala Ala  Gly Gly Val Gly Met  Ala Ala Val Ala Leu  Ala Arg Arg 
    2150                 2155                 2160             


Ala Gly  Ala Glu Val Leu Ala  Thr Ala Gly Pro Ala  Lys His Gly 
    2165                 2170                 2175             


Thr Leu  Arg Ala Leu Gly Leu  Asp Asp Glu His Ile  Ala Ser Ser 
    2180                 2185                 2190             


Arg Glu  Thr Gly Phe Ala Arg  Lys Phe Arg Glu Arg  Thr Gly Gly 
    2195                 2200                 2205             


Arg Gly  Val Asp Val Val Leu  Asn Ser Leu Thr Gly  Glu Leu Leu 
    2210                 2215                 2220             


Asp Glu  Ser Ala Asp Leu Leu  Ala Glu Asp Gly Val  Phe Val Glu 
    2225                 2230                 2235             


Met Gly  Lys Thr Asp Leu Arg  Asp Ala Gly Asp Phe  Arg Gly Arg 
    2240                 2245                 2250             


Tyr Ala  Pro Phe Asp Leu Gly  Glu Ala Gly Asp Asp  Arg Leu Gly 
    2255                 2260                 2265             


Glu Ile  Leu Arg Glu Val Val  Gly Leu Leu Gly Ala  Gly Glu Leu 
    2270                 2275                 2280             


Asp Arg  Leu Pro Val Ser Ala  Trp Glu Leu Gly Ile  Pro Gln Thr 
    2285                 2290                 2295             


Gly Lys  Ser Leu Val Thr Leu  Pro Pro Glu Gln Ala  Gln Val Phe 
    2300                 2305                 2310             


Arg Pro  Asp Gly Thr Val Leu  Ile Thr Gly Gly Thr  Gly Thr Leu 
    2315                 2320                 2325             


Gly Arg  Leu Leu Ala Arg His  Leu Val Thr Glu His  Gly Val Arg 
    2330                 2335                 2340             


His Leu  Leu Leu Val Ser Arg  Arg Gly Ala Asp Ala  Pro Gly Ser 
    2345                 2350                 2355             


Asp Glu  Leu Arg Ala Glu Ile  Glu Asp Leu Gly Ala  Ser Ala Glu 
    2360                 2365                 2370             


Ile Ala  Ala Cys Asp Thr Ala  Asp Arg Asp Ala Leu  Ser Ala Leu 
    2375                 2380                 2385             


Leu Asp  Gly Leu Pro Arg Pro  Leu Thr Gly Val Val  His Ala Ala 
    2390                 2395                 2400             


Gly Val  Leu Ala Asp Gly Leu  Val Thr Ser Ile Asp  Glu Pro Ala 
    2405                 2410                 2415             


Val Glu  Gln Val Leu Arg Ala  Lys Val Asp Ala Ala  Trp Asn Leu 
    2420                 2425                 2430             


His Glu  Leu Thr Ala Asn Thr  Gly Leu Ser Phe Phe  Val Leu Phe 
    2435                 2440                 2445             


Ser Ser  Ala Ala Ser Val Leu  Ala Gly Pro Gly Gln  Gly Val Tyr 
    2450                 2455                 2460             


Ala Ala  Ala Asn Glu Ser Leu  Asn Ala Leu Ala Ala  Leu Arg Arg 
    2465                 2470                 2475             


Thr Arg  Gly Leu Pro Ala Lys  Ala Leu Gly Trp Gly  Leu Trp Ala 
    2480                 2485                 2490             


Ile Gly  Arg Ala Ile Ala Phe  Ala Glu Gln Thr Gly  Asp Ala Ile 
    2495                 2500                 2505             


Ala Pro  Glu Glu Gly Ala Tyr  Ala Phe Glu Thr Leu  Leu Arg His 
    2510                 2515                 2520             


Asn Arg  Ala Tyr Ser Gly Tyr  Ala Pro Val Ile Gly  Ser Pro Trp 
    2525                 2530                 2535             


Leu Thr  Ala Phe Ala Gln His  Ser Pro Phe Ala Glu  Lys Phe Gln 
    2540                 2545                 2550             


Ser Leu  Gly Gln Asn Arg Ser  Gly Thr Ser Lys Phe  Leu Ala Glu 
    2555                 2560                 2565             


Leu Val  Asp Leu Pro Arg Glu  Glu Trp Pro Asp Arg  Leu Arg Arg 
    2570                 2575                 2580             


Leu Leu  Glu Leu Val Arg Ser  His Ala Ala Ala Val  Ser Gly Tyr 
    2585                 2590                 2595             


Gly Ser  Ala Asp Gln Leu Pro  Glu Arg Lys Ala Phe  Lys Asp Leu 
    2600                 2605                 2610             


Gly Phe  Asp Ser Leu Ala Ala  Val Glu Leu Arg Asn  Arg Leu Gly 
    2615                 2620                 2625             


Thr Ala  Thr Gly Val Arg Leu  Pro Ser Thr Leu Val  Phe Asp His 
    2630                 2635                 2640             


Pro Thr  Pro Leu Ala Val Ala  Glu His Leu Arg Asp  Arg Leu Leu 
    2645                 2650                 2655             


Ala Ser  Ala Arg Ala Pro Arg  Asp Val Arg Gln Thr  Ala His Ala 
    2660                 2665                 2670             


Asp Ala  Ala Glu Pro Ala Gly  Asp Asp Gly Leu Gln  His Leu Pro 
    2675                 2680                 2685             


Leu Val  Ala Ala Gln Pro Gly  Ile Trp Met Ala Glu  Lys Leu Ser 
    2690                 2695                 2700             


Glu Leu  Pro Ser Ala Trp Ser  Val Ala His Tyr Val  Glu Leu Thr 
    2705                 2710                 2715             


Gly Glu  Val Asp Ser Pro Leu  Leu Ala Arg Ala Val  Val Ala Gly 
    2720                 2725                 2730             


Leu Ala  Gln Ala Asp Thr Leu  Arg Met Arg Phe Thr  Glu Asp Asn 
    2735                 2740                 2745             


Gly Glu  Val Trp Gln Trp Val  Asp Asp Ala Leu Thr  Phe Glu Leu 
    2750                 2755                 2760             


Pro Glu  Ile Ile Asp Leu Arg  Thr Asn Ile Asp Pro  His Gly Thr 
    2765                 2770                 2775             


Ala Gln  Ala Leu Met Gln Ala  Asp Leu Gln Gln Asp  Leu Arg Val 
    2780                 2785                 2790             


Asp Ser  Gly Lys Pro Leu Val  Phe His Gln Leu Ile  Gln Val Ala 
    2795                 2800                 2805             


Asp Asn  Arg Trp Tyr Trp Tyr  Gln Arg Tyr His His  Leu Leu Val 
    2810                 2815                 2820             


Asp Gly  Phe Ser Phe Pro Ala  Ile Thr Arg Gln Ile  Ala Asn Ile 
    2825                 2830                 2835             


Tyr Cys  Thr Trp Leu Arg Gly  Glu Pro Thr Pro Ala  Ser Pro Phe 
    2840                 2845                 2850             


Thr Pro  Phe Ala Asp Val Val  Glu Glu Tyr Gln Gln  Tyr Arg Glu 
    2855                 2860                 2865             


Ser Glu  Ala Trp Gln Arg Asp  Ala Ala Phe Trp Ala  Glu Gln Arg 
    2870                 2875                 2880             


Arg Gln  Leu Pro Pro Pro Ala  Ser Leu Ser Pro Ala  Pro Leu Pro 
    2885                 2890                 2895             


Gly Arg  Ser Ala Ser Ala Asp  Ile Leu Arg Leu Lys  Leu Glu Phe 
    2900                 2905                 2910             


Thr Asp  Gly Glu Phe Arg Gln  Leu Ala Thr Gln Leu  Ser Gly Val 
    2915                 2920                 2925             


Gln Arg  Thr Asp Leu Ala Leu  Ala Leu Ala Ala Leu  Trp Leu Gly 
    2930                 2935                 2940             


Arg Leu  Cys Asn Arg Met Asp  Tyr Ala Ala Gly Phe  Ile Phe Met 
    2945                 2950                 2955             


Arg Arg  Leu Gly Ser Ala Ala  Leu Thr Ala Thr Gly  Pro Val Leu 
    2960                 2965                 2970             


Asn Val  Leu Pro Leu Gly Ile  His Ile Gly Asn Pro  Ser Phe Ser 
    2975                 2980                 2985             


Glu Leu  Leu Thr Arg Val Arg  Glu Val Ala Leu Gly  Ala Tyr Ala 
    2990                 2995                 3000             


His Gln  His Ile Pro Phe Glu  Met Leu Val Glu Ala  Leu Gln Pro 
    3005                 3010                 3015             


Glu Arg  Asn Leu Ser His Thr  Pro Leu Phe Gln Val  Met Phe Val 
    3020                 3025                 3030             


Leu Gln  Asn Ala Pro Ala Ser  Gln Leu Glu Leu Thr  Gly Ile Thr 
    3035                 3040                 3045             


Ala Asn  Pro Ile Lys Val Lys  Ser Thr Thr Thr Lys  Phe Asp Leu 
    3050                 3055                 3060             


Thr Leu  Ile Met Gln Asn Thr  Ala Ser Gly Leu Val  Gly Val Trp 
    3065                 3070                 3075             


Glu Tyr  Asn Thr Asp Leu Phe  Asp Ala Ser Thr Ile  Glu Arg Met 
    3080                 3085                 3090             


Thr Gly  His Phe Val Thr Leu  Leu Glu Gly Val Ile  Ala Asn Pro 
    3095                 3100                 3105             


Gln Gln  Pro Ile Ser Gln Leu  Pro Ile Leu Thr Thr  Val Glu Gln 
    3110                 3115                 3120             


Gln Gln  Leu Leu Val Glu Trp  Asn Asn Thr Gln Thr  Asp Tyr Pro 
    3125                 3130                 3135             


Ala Asp  Lys Cys Ile His Gln  Leu Phe Glu Glu Gln  Val Glu Arg 
    3140                 3145                 3150             


Thr Pro  Asp Ala Val Ala Val  Val Phe Gly Asn Gln  Gln Leu Ser 
    3155                 3160                 3165             


Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala Leu Ala  Asn Leu Leu 
    3170                 3175                 3180             


Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser Val Ala  Val Ala Leu 
    3185                 3190                 3195             


Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu His Ala  Ile Val Glu 
    3200                 3205                 3210             


Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr Gly Tyr  Pro Asp Asp 
    3215                 3220                 3225             


Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg Pro Ser  Leu Leu Ile 
    3230                 3235                 3240             


Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser Asp Val  Pro Asn Leu 
    3245                 3250                 3255             


Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr Pro Gln  Gly Ser Ala 
    3260                 3265                 3270             


Pro Leu  Gln Leu Ser Gln Pro  His His Thr Ala Tyr  Ile Ile Phe 
    3275                 3280                 3285             


Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly Val Met  Val Gly Gln 
    3290                 3295                 3300             


Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met Gln Asn  His Tyr Pro 
    3305                 3310                 3315             


Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys Thr Pro  Cys Ser Phe 
    3320                 3325                 3330             


Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro Phe Ile  Ala Gly Ala 
    3335                 3340                 3345             


Lys Leu  Val Met Ala Glu Pro  Glu Ala His Arg Asp  Pro Leu Ala 
    3350                 3355                 3360             


Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val Thr Thr  Thr His Phe 
    3365                 3370                 3375             


Val Pro  Ser Met Leu Ala Ala  Phe Val Ala Ser Leu  Thr Pro Gln 
    3380                 3385                 3390             


Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys Gln Val  Phe Cys Ser 
    3395                 3400                 3405             


Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg Glu Trp  Gln Gln Leu 
    3410                 3415                 3420             


Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly Pro Thr  Glu Ala Ala 
    3425                 3430                 3435             


Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly Glu Glu  Leu Ala Gln 
    3440                 3445                 3450             


Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr Pro Val  Trp Asn Thr 
    3455                 3460                 3465             


Gly Leu  Arg Ile Leu Asp Ala  Met Met His Pro Val  Pro Pro Gly 
    3470                 3475                 3480             


Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile Gln Leu  Ala Gln Gly 
    3485                 3490                 3495             


Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser Arg Phe  Ile Ala Asp 
    3500                 3505                 3510             


Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg Thr Gly  Asp Val Ala 
    3515                 3520                 3525             


Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr Leu Gly  Arg Ser Asp 
    3530                 3535                 3540             


Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile Glu Leu  Gly Glu Ile 
    3545                 3550                 3555             


Asp Arg  Val Met Gln Ala Leu  Pro Asp Val Glu Gln  Ala Val Ala 
    3560                 3565                 3570             


Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro Gly Asn  Lys His Leu 
    3575                 3580                 3585             


Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln Thr Cys  Thr Glu Arg 
    3590                 3595                 3600             


Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val Arg Ser  Phe Leu Lys 
    3605                 3610                 3615             


Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser Ala Ile  Val Ile Leu 
    3620                 3625                 3630             


Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys Leu Asp  Arg Arg Ala 
    3635                 3640                 3645             


Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu Glu Thr  Ile Ile Ala 
    3650                 3655                 3660             


Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp Val Gln  Asp Ala Asp 
    3665                 3670                 3675             


Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser Leu Leu  Ala Met Lys 
    3680                 3685                 3690             


Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala Arg Gln  Val Thr Pro 
    3695                 3700                 3705             


Gly Gln  Val Met Val Ala Ser  Thr Val Ala Lys Leu  Ala Thr Ile 
    3710                 3715                 3720             


Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala Pro Arg  Asn Pro Ile 
    3725                 3730                 3735             


Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu Cys Gln  Gly Asp Gly 
    3740                 3745                 3750             


Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe Gly Pro  Pro Val Glu 
    3755                 3760                 3765             


His Arg  Ala Arg Leu Val Cys  Phe Pro His Ala Gly  Ala Ala Ala 
    3770                 3775                 3780             


Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu Ala Pro  Glu Ile Asp 
    3785                 3790                 3795             


Val His  Ala Val Gln Tyr Pro  Gly Arg Gln Asp Arg  Arg Asp Glu 
    3800                 3805                 3810             


Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala Asp Glu  Val Ala Ala 
    3815                 3820                 3825             


Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro Phe Ala  Leu Phe Gly 
    3830                 3835                 3840             


His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu Thr Ala  Arg Arg Leu 
    3845                 3850                 3855             


Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg Leu Phe  Val Ser Gly 
    3860                 3865                 3870             


Gln Thr  Ala Pro Arg Val His  Glu Arg Arg Thr Asp  Leu Pro Gly 
    3875                 3880                 3885             


Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg Leu Gly  Thr Ser Glu 
    3890                 3895                 3900             


Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala Met Ser  Leu Pro Val 
    3905                 3910                 3915             


Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser Tyr Ala  Trp Ala Asp 
    3920                 3925                 3930             


Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala Leu Cys  Gly Asp Ala 
    3935                 3940                 3945             


Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu Arg Trp  Leu Gln His 
    3950                 3955                 3960             


Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe Pro Gly  Gly His Phe 
    3965                 3970                 3975             


Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala Gly Ala  Val Arg Arg 
    3980                 3985                 3990             


Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    3995                 4000         


<210>  142
<211>  9099
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-Ser

<400>  142
atggttgcca aacatagtct ggaaaacggt gtctttcaca agatgactga aaacgagaag       60

gaattgatcc ttcatttcaa caacactaag acagattacc ctaagaacaa gacgttgcat      120

gaactttttg aagagcaggc aatgaaaacc ccggatcaca cagcactggt gttcggcgct      180

cagagaatga cctacaggga actgaacgag aaggcgaatc aaacggcccg tctgttacgc      240

gaaaaaggga tcggacgtgg cagcattgcg gccattatcg cagatcgctc ttttgaaatg      300

atcatcggaa tcatcggcat cctaaaggca ggcggtgctt atctgccgat tgacccagaa      360

accccgaaag atcgtatcgc gttcatgctg agcgatacca aggcagctgt attgcttacg      420

cagggaaaag cggccgatgg cattgactgc gaagcggata tcgtgcaact ggaccgtgaa      480

gccagcgatg gtttttctaa agagccgctg agctctgtta atgatagtgg cgacaccgcg      540

tatattatct acacgagtgg ttccaccggg accccgaaag gtgtgattac cccgcattat      600

tccgttatcc gcgtggttca gaacactaac tacatcgata tcacagaaga caacgtaatc      660

ctccaactat caaactactc gttcgacggt agtgtgtttg atattttcgg tgcgctccta      720

aacggggcct ccctggtgat gatcgagaaa gaagcactgt taaacattaa tcgtctgggc      780

tcagctatca atgaagagaa agtgagcgtg atgtttatta ccacggcgct gttcaacatg      840

attgccgata tccatgttga ctgcctctca aacctgcgta aaattctgtt tggcggcgaa      900

cgagcttcga tcccacatgt ccgcaaggta ctgaaccacg tcggtcgcga taaattaatt      960

cacgtatatg gcccgactga atcaacagtg tacgccacct attacttcat aaacgaaatt     1020

gatgacgagg cggaaactat ccccataggt agcccgctgg ccaataccag cgtgctgatt     1080

atggacgaag caggcaaact ggtcccaatt ggagtacctg gcgaactgtg tatcgctggt     1140

gatgggttgt ctaaaggtta tcttaaccgt gaagagctca ccgcggaaaa atttatcccg     1200

catccattca ttcccggtga acgtctgtac aagacgggcg accttgccaa atggctccca     1260

gatggaaata tcgaatttat aggccgcatt gatcatcagg ttaaaatccg tggctttcga     1320

attgaactgg gggagatcga aagccgttta gaaatgcacg aggacatcaa cgaaaccatt     1380

gtgacggttc gcgaggatga agagagccgg ccgtatatct gtgcatacat taccgctaat     1440

cgtgaaattt ctcttgatga gctcaagggt tttctggggg aaaaattacc cgagtatatg     1500

atcccggcgt acttcgttaa gctggataaa ctgccgttaa cgaagaatgg taaagtcgac     1560

cggaaagccc tgcctgaacc cgatcgtact gcgggcgccg agaacgaata tgaggcaccg     1620

cgcaatgaaa cagaagagaa actggcagct gtctggcagg acgtgttaca tgttgaaaaa     1680

gcaggcattc atgatcactt tgctcaaatg ggcggtcatt cattgcacgc aatggaactt     1740

atcgctaaga tcaaggaaaa gatgaacgtt gagatcccgc tgcaccagtt atttaagttg     1800

gcgaccatta aagaactgtc ggcgttcatc gaggccaatg ccattcagac aggcgcatca     1860

ctgtcaattc cggcaatcca atcgcgcagc aaccgtgacc agcacttgcc cttagtagct     1920

gcgcaacctg gaatatggat ggccgagaag ttatctgaac taccatcagc gtggagcgta     1980

gcgcattacg tggagctcac tggtgaggtt gactcgcctc ttttggccag ggcggtagtg     2040

gctggccttg cacaagctga caccttaaga atgcgtttca cagaggataa tggggaagtt     2100

tggcaatggg tagacgatgc gttaacattt gagttaccgg aaatcataga cctgcgcact     2160

aacatagacc ctcacgggac agctcaggcc ttgatgcaag cggacctgca acaggaccta     2220

cgtgtggatt cggggaagcc tctggtcttc catcagctaa ttcaagtagc ggacaatcgc     2280

tggtactggt atcaaaggta ccaccacttg cttgtggacg ggttcagttt tccagcgata     2340

accaggcaaa tagccaacat ttattgcact tggttgcgag gagagcctac gcccgcatcc     2400

cccttcacgc cattcgcaga cgttgttgag gaataccaac agtatcgcga gagcgaagcg     2460

tggcaacgcg atgcggcatt ctgggcggag caacgacggc aactaccgcc tcccgcatcc     2520

ctatcacctg ccccgctccc cggccggtcc gcgtcagccg acattctacg gctaaagctg     2580

gagttcacag atggtgaatt tcgacagctt gctacacaac tcagcggggt acaaaggaca     2640

gacctagcgc tcgctctggc tgcattatgg ctaggacgac tttgcaatcg aatggactac     2700

gcggcgggtt tcatatttat gcgccggctc ggcagcgcag cgttgaccgc aacgggtcca     2760

gttttaaatg ttcttccttt gggaatccac ataggcaacc caagcttctc tgagcttctc     2820

accagggttc gcgaggtcgc cttaggcgcg tatgcacacc aacatattcc ttttgagatg     2880

ttagtagagg cactgcaacc agagcgaaac cttagccata ctcctctctt ccaagtgatg     2940

tttgtccttc agaatgcgcc cgcgtcccaa ttagagttaa ccgggatcac cgcaaaccca     3000

attaaggtta aatcaactac cacgaagttc gacctaactt taatcatgca aaacacagct     3060

agcggattag taggtgtttg ggagtacaac acggatttat tcgacgcgtc aacgattgag     3120

cgaatgacag ggcactttgt aaccctcctc gagggcgtta tcgccaatcc acaacagccg     3180

atctctcaac ttcctatttt aactacagtg gagcaacagc aacttttagt cgagtggaat     3240

aacacgcaaa ccgactaccc cgctgataag tgtatacatc aattattcga ggaacaggtc     3300

gagcgcacac cagacgccgt tgctgtcgtc tttgggaatc agcaactcag ctatcgagag     3360

atgcgcgaac aagtggttgc actcgccaat ttattacgtg agcggggagt caagccagga     3420

gactccgttg ccgtggcctt accacgctct gttttcttaa cccttgcact acacgcgatt     3480

gtcgaggcag gtgccgcctg gctacctctt gacacaggat atcctgacga tagattaaaa     3540

atgatgctcg aggatgcacg gccttccctt ctgatcacaa cagacgatca attaccccgc     3600

ttcagtgacg tacctaatct gacctcactc tgttacaacg ctcccttgac gcctcaaggg     3660

agcgcccctt tacagctgtc tcaacctcac catactgcat atatcatctt tacaagtggt     3720

tctacgggac gccccaaggg agtaatggtt ggtcagactg cgattgtaaa tcgtctgttg     3780

tggatgcaaa accactaccc tttgacgggg gaggacgttg tagcccaaaa gactccttgc     3840

tcgttcgatg tctcagtctg ggagttcttt tggccattta tagcaggggc caaattagtt     3900

atggcggagc cggaagccca ccgagaccca cttgcgatgc agcaattctt tgctgagtat     3960

ggtgtcacca ctacacattt cgtcccatcg atgttagcgg ccttcgtggc ttctcttact     4020

ccacaaacgg ctaggcaatc ttgtgccaca ctaaagcaag tcttctgctc cggcgaggca     4080

ttacctgcag acttgtgccg ggaatggcag caactcacag gagctccatt gcacaatcta     4140

tacggaccga ccgaggccgc agtagacgta tcttggtatc ctgcgtttgg cgaggagtta     4200

gcgcaagtaa gaggttcgtc agtaccaata ggataccccg tatggaacac ggggcttcgg     4260

atactggacg cgatgatgca tccggtccca ccaggagtcg cgggcgattt atacctgact     4320

gggatacagc tggcccaagg ttacctaggg agacctgacc ttacggcgtc gaggttcata     4380

gcggatccgt ttgctccggg tgagcgcatg taccgtacgg gcgacgtcgc gcgatggcta     4440

gataatggcg ccgtagagta tcttggtaga tcagacgatc agttaaagat acggggacaa     4500

cgaatagagc ttggggaaat agaccgggta atgcaggctt tgccagatgt cgagcaagcg     4560

gtggcttcgt gtgctattgc gcgggaggac atacctggga acaaacacct tgtagcgtac     4620

atagttcctc aagaggagca aacatgcact gagcgatcga ggtccacact tacagtttcg     4680

ttcgtccgga gtttccttaa ggagaaactc cccgaatata tggtaccgag cgcaatagtg     4740

attctagacg ctctccccct gactcctaat ggaaagctag accggcgggc gttacccgcc     4800

cctgacctgc actcacaact tgagacaatt attgctgcgg ctttctcgag cctgctcggg     4860

tgcgacgtac aagacgcgga tgctgacttt ttcgcgctag gtggccattc gctgcttgcc     4920

atgaagctag ccgctcagct ttcccgacaa gtagcgcggc aggtgacacc aggccaagtt     4980

atggtagctt cgactgtcgc aaagctcgca acgatcatag acgcggagtt agataaatac     5040

gtcgctccaa ggaacccgat attggcttcc gctcgtgctc cgcgtgacgt ccgccaaaca     5100

gctcacgctg acgctgctga accggctggc gacgacggcc ttcagcactt gcccttagta     5160

gctgcgcaac ctggaatatg gatggccgag aagttatctg aactaccatc agcgtggagc     5220

gtagcgcatt acgtggagct cactggtgag gttgactcgc ctcttttggc cagggcggta     5280

gtggctggcc ttgcacaagc tgacacctta agaatgcgtt tcacagagga taatggggaa     5340

gtttggcaat gggtagacga tgcgttaaca tttgagttac cggaaatcat agacctgcgc     5400

actaacatag accctcacgg gacagctcag gccttgatgc aagcggacct gcaacaggac     5460

ctacgtgtgg attcggggaa gcctctggtc ttccatcagc taattcaagt agcggacaat     5520

cgctggtact ggtatcaaag gtaccaccac ttgcttgtgg acgggttcag ttttccagcg     5580

ataaccaggc aaatagccaa catttattgc acttggttgc gaggagagcc tacgcccgca     5640

tcccccttca cgccattcgc agacgttgtt gaggaatacc aacagtatcg cgagagcgaa     5700

gcgtggcaac gcgatgcggc attctgggcg gagcaacgac ggcaactacc gcctcccgca     5760

tccctatcac ctgccccgct ccccggccgg tccgcgtcag ccgacattct acggctaaag     5820

ctggagttca cagatggtga atttcgacag cttgctacac aactcagcgg ggtacaaagg     5880

acagacctag cgctcgctct ggctgcatta tggctaggac gactttgcaa tcgaatggac     5940

tacgcggcgg gtttcatatt tatgcgccgg ctcggcagcg cagcgttgac cgcaacgggt     6000

ccagttttaa atgttcttcc tttgggaatc cacataggca acccaagctt ctctgagctt     6060

ctcaccaggg ttcgcgaggt cgccttaggc gcgtatgcac accaacatat tccttttgag     6120

atgttagtag aggcactgca accagagcga aaccttagcc atactcctct cttccaagtg     6180

atgtttgtcc ttcagaatgc gcccgcgtcc caattagagt taaccgggat caccgcaaac     6240

ccaattaagg ttaaatcaac taccacgaag ttcgacctaa ctttaatcat gcaaaacaca     6300

gctagcggat tagtaggtgt ttgggagtac aacacggatt tattcgacgc gtcaacgatt     6360

gagcgaatga cagggcactt tgtaaccctc ctcgagggcg ttatcgccaa tccacaacag     6420

ccgatctctc aacttcctat tttaactaca gtggagcaac agcaactttt agtcgagtgg     6480

aataacacgc aaaccgacta ccccgctgat aagtgtatac atcaattatt cgaggaacag     6540

gtcgagcgca caccagacgc cgttgctgtc gtctttggga atcagcaact cagctatcga     6600

gagatgcgcg aacaagtggt tgcactcgcc aatttattac gtgagcgggg agtcaagcca     6660

ggagactccg ttgccgtggc cttaccacgc tctgttttct taacccttgc actacacgcg     6720

attgtcgagg caggtgccgc ctggctacct cttgacacag gatatcctga cgatagatta     6780

aaaatgatgc tcgaggatgc acggccttcc cttctgatca caacagacga tcaattaccc     6840

cgcttcagtg acgtacctaa tctgacctca ctctgttaca acgctccctt gacgcctcaa     6900

gggagcgccc ctttacagct gtctcaacct caccatactg catatatcat ctttacaagt     6960

ggttctacgg gacgccccaa gggagtaatg gttggtcaga ctgcgattgt aaatcgtctg     7020

ttgtggatgc aaaaccacta ccctttgacg ggggaggacg ttgtagccca aaagactcct     7080

tgctcgttcg atgtctcagt ctgggagttc ttttggccat ttatagcagg ggccaaatta     7140

gttatggcgg agccggaagc ccaccgagac ccacttgcga tgcagcaatt ctttgctgag     7200

tatggtgtca ccactacaca tttcgtccca tcgatgttag cggccttcgt ggcttctctt     7260

actccacaaa cggctaggca atcttgtgcc acactaaagc aagtcttctg ctccggcgag     7320

gcattacctg cagacttgtg ccgggaatgg cagcaactca caggagctcc attgcacaat     7380

ctatacggac cgaccgaggc cgcagtagac gtatcttggt atcctgcgtt tggcgaggag     7440

ttagcgcaag taagaggttc gtcagtacca ataggatacc ccgtatggaa cacggggctt     7500

cggatactgg acgcgatgat gcatccggtc ccaccaggag tcgcgggcga tttatacctg     7560

actgggatac agctggccca aggttaccta gggagacctg accttacggc gtcgaggttc     7620

atagcggatc cgtttgctcc gggtgagcgc atgtaccgta cgggcgacgt cgcgcgatgg     7680

ctagataatg gcgccgtaga gtatcttggt agatcagacg atcagttaaa gatacgggga     7740

caacgaatag agcttgggga aatagaccgg gtaatgcagg ctttgccaga tgtcgagcaa     7800

gcggtggctt cgtgtgctat tgcgcgggag gacatacctg ggaacaaaca ccttgtagcg     7860

tacatagttc ctcaagagga gcaaacatgc actgagcgat cgaggtccac acttacagtt     7920

tcgttcgtcc ggagtttcct taaggagaaa ctccccgaat atatggtacc gagcgcaata     7980

gtgattctag acgctctccc cctgactcct aatggaaagc tagaccggcg ggcgttaccc     8040

gcccctgacc tgcactcaca acttgagaca attattgctg cggctttctc gagcctgctc     8100

gggtgcgacg tacaagacgc ggatgctgac tttttcgcgc taggtggcca ttcgctgctt     8160

gccatgaagc tagccgctca gctttcccga caagtagcgc ggcaggtgac accaggccaa     8220

gttatggtag cttcgactgt cgcaaagctc gcaacgatca tagacgcgga gttagataaa     8280

tacgtcgctc caaggaaccc gataacatcc ggggaagata accctatccc cctatgtcaa     8340

ggcgatgggg aggagatgag cacatggcta cgtcgttttg gacccccagt cgaacatcgg     8400

gccaggctag tgtgtttccc ccacgcaggc gcagcggcgg attcatactt agacctagca     8460

agagcgttag caccagagat cgatgttcat gctgttcaat accccggcag gcaagacaga     8520

agggacgagg agccattagg aaccgcaggt gaaattgcag atgaagtggc agcggtgcta     8580

cgtgcgtcgg gaggggatgg gccttttgca cttttcggcc acagtatggg cgccctcatc     8640

gcgtacgaga cagcaaggcg attagagagg gaaccgggag ggggaccctt acgtttattc     8700

gtgagcggac aaacagcgcc acgtgtccat gaacgaagaa ctgatctgcc cggtgacgat     8760

ggactcgtgg acgagcttag gcgacttggc acctccgagg cagcgctcgc agacgaagcc     8820

ctgctggcta tgtctctccc ggtgctcagg gcggattata gggtgttaag atcctacgct     8880

tgggcggatg gtcccccact acgcgccggt ataactgccc tctgcggtga tgcagaccca     8940

ctaactgcaa caggggatgc ggaacgctgg ttacaacatt ccgtgattcc gggtcggaca     9000

cggacatttc ccggtgggca tttttattta ggggaacaag tgaccgaggt ggcaggggct     9060

gtccgtagag atttactgag agcagggtta gcgggttga                            9099


<210>  143
<211>  3032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ile-Ser-Ser

<400>  143

Met Val Ala Lys His Ser Leu Glu Asn Gly Val Phe His Lys Met Thr 
1               5                   10                  15      


Glu Asn Glu Lys Glu Leu Ile Leu His Phe Asn Asn Thr Lys Thr Asp 
            20                  25                  30          


Tyr Pro Lys Asn Lys Thr Leu His Glu Leu Phe Glu Glu Gln Ala Met 
        35                  40                  45              


Lys Thr Pro Asp His Thr Ala Leu Val Phe Gly Ala Gln Arg Met Thr 
    50                  55                  60                  


Tyr Arg Glu Leu Asn Glu Lys Ala Asn Gln Thr Ala Arg Leu Leu Arg 
65                  70                  75                  80  


Glu Lys Gly Ile Gly Arg Gly Ser Ile Ala Ala Ile Ile Ala Asp Arg 
                85                  90                  95      


Ser Phe Glu Met Ile Ile Gly Ile Ile Gly Ile Leu Lys Ala Gly Gly 
            100                 105                 110         


Ala Tyr Leu Pro Ile Asp Pro Glu Thr Pro Lys Asp Arg Ile Ala Phe 
        115                 120                 125             


Met Leu Ser Asp Thr Lys Ala Ala Val Leu Leu Thr Gln Gly Lys Ala 
    130                 135                 140                 


Ala Asp Gly Ile Asp Cys Glu Ala Asp Ile Val Gln Leu Asp Arg Glu 
145                 150                 155                 160 


Ala Ser Asp Gly Phe Ser Lys Glu Pro Leu Ser Ser Val Asn Asp Ser 
                165                 170                 175     


Gly Asp Thr Ala Tyr Ile Ile Tyr Thr Ser Gly Ser Thr Gly Thr Pro 
            180                 185                 190         


Lys Gly Val Ile Thr Pro His Tyr Ser Val Ile Arg Val Val Gln Asn 
        195                 200                 205             


Thr Asn Tyr Ile Asp Ile Thr Glu Asp Asn Val Ile Leu Gln Leu Ser 
    210                 215                 220                 


Asn Tyr Ser Phe Asp Gly Ser Val Phe Asp Ile Phe Gly Ala Leu Leu 
225                 230                 235                 240 


Asn Gly Ala Ser Leu Val Met Ile Glu Lys Glu Ala Leu Leu Asn Ile 
                245                 250                 255     


Asn Arg Leu Gly Ser Ala Ile Asn Glu Glu Lys Val Ser Val Met Phe 
            260                 265                 270         


Ile Thr Thr Ala Leu Phe Asn Met Ile Ala Asp Ile His Val Asp Cys 
        275                 280                 285             


Leu Ser Asn Leu Arg Lys Ile Leu Phe Gly Gly Glu Arg Ala Ser Ile 
    290                 295                 300                 


Pro His Val Arg Lys Val Leu Asn His Val Gly Arg Asp Lys Leu Ile 
305                 310                 315                 320 


His Val Tyr Gly Pro Thr Glu Ser Thr Val Tyr Ala Thr Tyr Tyr Phe 
                325                 330                 335     


Ile Asn Glu Ile Asp Asp Glu Ala Glu Thr Ile Pro Ile Gly Ser Pro 
            340                 345                 350         


Leu Ala Asn Thr Ser Val Leu Ile Met Asp Glu Ala Gly Lys Leu Val 
        355                 360                 365             


Pro Ile Gly Val Pro Gly Glu Leu Cys Ile Ala Gly Asp Gly Leu Ser 
    370                 375                 380                 


Lys Gly Tyr Leu Asn Arg Glu Glu Leu Thr Ala Glu Lys Phe Ile Pro 
385                 390                 395                 400 


His Pro Phe Ile Pro Gly Glu Arg Leu Tyr Lys Thr Gly Asp Leu Ala 
                405                 410                 415     


Lys Trp Leu Pro Asp Gly Asn Ile Glu Phe Ile Gly Arg Ile Asp His 
            420                 425                 430         


Gln Val Lys Ile Arg Gly Phe Arg Ile Glu Leu Gly Glu Ile Glu Ser 
        435                 440                 445             


Arg Leu Glu Met His Glu Asp Ile Asn Glu Thr Ile Val Thr Val Arg 
    450                 455                 460                 


Glu Asp Glu Glu Ser Arg Pro Tyr Ile Cys Ala Tyr Ile Thr Ala Asn 
465                 470                 475                 480 


Arg Glu Ile Ser Leu Asp Glu Leu Lys Gly Phe Leu Gly Glu Lys Leu 
                485                 490                 495     


Pro Glu Tyr Met Ile Pro Ala Tyr Phe Val Lys Leu Asp Lys Leu Pro 
            500                 505                 510         


Leu Thr Lys Asn Gly Lys Val Asp Arg Lys Ala Leu Pro Glu Pro Asp 
        515                 520                 525             


Arg Thr Ala Gly Ala Glu Asn Glu Tyr Glu Ala Pro Arg Asn Glu Thr 
    530                 535                 540                 


Glu Glu Lys Leu Ala Ala Val Trp Gln Asp Val Leu His Val Glu Lys 
545                 550                 555                 560 


Ala Gly Ile His Asp His Phe Ala Gln Met Gly Gly His Ser Leu His 
                565                 570                 575     


Ala Met Glu Leu Ile Ala Lys Ile Lys Glu Lys Met Asn Val Glu Ile 
            580                 585                 590         


Pro Leu His Gln Leu Phe Lys Leu Ala Thr Ile Lys Glu Leu Ser Ala 
        595                 600                 605             


Phe Ile Glu Ala Asn Ala Ile Gln Thr Gly Ala Ser Leu Ser Ile Pro 
    610                 615                 620                 


Ala Ile Gln Ser Arg Ser Asn Arg Asp Gln His Leu Pro Leu Val Ala 
625                 630                 635                 640 


Ala Gln Pro Gly Ile Trp Met Ala Glu Lys Leu Ser Glu Leu Pro Ser 
                645                 650                 655     


Ala Trp Ser Val Ala His Tyr Val Glu Leu Thr Gly Glu Val Asp Ser 
            660                 665                 670         


Pro Leu Leu Ala Arg Ala Val Val Ala Gly Leu Ala Gln Ala Asp Thr 
        675                 680                 685             


Leu Arg Met Arg Phe Thr Glu Asp Asn Gly Glu Val Trp Gln Trp Val 
    690                 695                 700                 


Asp Asp Ala Leu Thr Phe Glu Leu Pro Glu Ile Ile Asp Leu Arg Thr 
705                 710                 715                 720 


Asn Ile Asp Pro His Gly Thr Ala Gln Ala Leu Met Gln Ala Asp Leu 
                725                 730                 735     


Gln Gln Asp Leu Arg Val Asp Ser Gly Lys Pro Leu Val Phe His Gln 
            740                 745                 750         


Leu Ile Gln Val Ala Asp Asn Arg Trp Tyr Trp Tyr Gln Arg Tyr His 
        755                 760                 765             


His Leu Leu Val Asp Gly Phe Ser Phe Pro Ala Ile Thr Arg Gln Ile 
    770                 775                 780                 


Ala Asn Ile Tyr Cys Thr Trp Leu Arg Gly Glu Pro Thr Pro Ala Ser 
785                 790                 795                 800 


Pro Phe Thr Pro Phe Ala Asp Val Val Glu Glu Tyr Gln Gln Tyr Arg 
                805                 810                 815     


Glu Ser Glu Ala Trp Gln Arg Asp Ala Ala Phe Trp Ala Glu Gln Arg 
            820                 825                 830         


Arg Gln Leu Pro Pro Pro Ala Ser Leu Ser Pro Ala Pro Leu Pro Gly 
        835                 840                 845             


Arg Ser Ala Ser Ala Asp Ile Leu Arg Leu Lys Leu Glu Phe Thr Asp 
    850                 855                 860                 


Gly Glu Phe Arg Gln Leu Ala Thr Gln Leu Ser Gly Val Gln Arg Thr 
865                 870                 875                 880 


Asp Leu Ala Leu Ala Leu Ala Ala Leu Trp Leu Gly Arg Leu Cys Asn 
                885                 890                 895     


Arg Met Asp Tyr Ala Ala Gly Phe Ile Phe Met Arg Arg Leu Gly Ser 
            900                 905                 910         


Ala Ala Leu Thr Ala Thr Gly Pro Val Leu Asn Val Leu Pro Leu Gly 
        915                 920                 925             


Ile His Ile Gly Asn Pro Ser Phe Ser Glu Leu Leu Thr Arg Val Arg 
    930                 935                 940                 


Glu Val Ala Leu Gly Ala Tyr Ala His Gln His Ile Pro Phe Glu Met 
945                 950                 955                 960 


Leu Val Glu Ala Leu Gln Pro Glu Arg Asn Leu Ser His Thr Pro Leu 
                965                 970                 975     


Phe Gln Val Met Phe Val Leu Gln Asn Ala Pro Ala Ser Gln Leu Glu 
            980                 985                 990         


Leu Thr Gly Ile Thr Ala Asn Pro  Ile Lys Val Lys Ser  Thr Thr Thr 
        995                 1000                 1005             


Lys Phe  Asp Leu Thr Leu Ile  Met Gln Asn Thr Ala  Ser Gly Leu 
    1010                 1015                 1020             


Val Gly  Val Trp Glu Tyr Asn  Thr Asp Leu Phe Asp  Ala Ser Thr 
    1025                 1030                 1035             


Ile Glu  Arg Met Thr Gly His  Phe Val Thr Leu Leu  Glu Gly Val 
    1040                 1045                 1050             


Ile Ala  Asn Pro Gln Gln Pro  Ile Ser Gln Leu Pro  Ile Leu Thr 
    1055                 1060                 1065             


Thr Val  Glu Gln Gln Gln Leu  Leu Val Glu Trp Asn  Asn Thr Gln 
    1070                 1075                 1080             


Thr Asp  Tyr Pro Ala Asp Lys  Cys Ile His Gln Leu  Phe Glu Glu 
    1085                 1090                 1095             


Gln Val  Glu Arg Thr Pro Asp  Ala Val Ala Val Val  Phe Gly Asn 
    1100                 1105                 1110             


Gln Gln  Leu Ser Tyr Arg Glu  Met Arg Glu Gln Val  Val Ala Leu 
    1115                 1120                 1125             


Ala Asn  Leu Leu Arg Glu Arg  Gly Val Lys Pro Gly  Asp Ser Val 
    1130                 1135                 1140             


Ala Val  Ala Leu Pro Arg Ser  Val Phe Leu Thr Leu  Ala Leu His 
    1145                 1150                 1155             


Ala Ile  Val Glu Ala Gly Ala  Ala Trp Leu Pro Leu  Asp Thr Gly 
    1160                 1165                 1170             


Tyr Pro  Asp Asp Arg Leu Lys  Met Met Leu Glu Asp  Ala Arg Pro 
    1175                 1180                 1185             


Ser Leu  Leu Ile Thr Thr Asp  Asp Gln Leu Pro Arg  Phe Ser Asp 
    1190                 1195                 1200             


Val Pro  Asn Leu Thr Ser Leu  Cys Tyr Asn Ala Pro  Leu Thr Pro 
    1205                 1210                 1215             


Gln Gly  Ser Ala Pro Leu Gln  Leu Ser Gln Pro His  His Thr Ala 
    1220                 1225                 1230             


Tyr Ile  Ile Phe Thr Ser Gly  Ser Thr Gly Arg Pro  Lys Gly Val 
    1235                 1240                 1245             


Met Val  Gly Gln Thr Ala Ile  Val Asn Arg Leu Leu  Trp Met Gln 
    1250                 1255                 1260             


Asn His  Tyr Pro Leu Thr Gly  Glu Asp Val Val Ala  Gln Lys Thr 
    1265                 1270                 1275             


Pro Cys  Ser Phe Asp Val Ser  Val Trp Glu Phe Phe  Trp Pro Phe 
    1280                 1285                 1290             


Ile Ala  Gly Ala Lys Leu Val  Met Ala Glu Pro Glu  Ala His Arg 
    1295                 1300                 1305             


Asp Pro  Leu Ala Met Gln Gln  Phe Phe Ala Glu Tyr  Gly Val Thr 
    1310                 1315                 1320             


Thr Thr  His Phe Val Pro Ser  Met Leu Ala Ala Phe  Val Ala Ser 
    1325                 1330                 1335             


Leu Thr  Pro Gln Thr Ala Arg  Gln Ser Cys Ala Thr  Leu Lys Gln 
    1340                 1345                 1350             


Val Phe  Cys Ser Gly Glu Ala  Leu Pro Ala Asp Leu  Cys Arg Glu 
    1355                 1360                 1365             


Trp Gln  Gln Leu Thr Gly Ala  Pro Leu His Asn Leu  Tyr Gly Pro 
    1370                 1375                 1380             


Thr Glu  Ala Ala Val Asp Val  Ser Trp Tyr Pro Ala  Phe Gly Glu 
    1385                 1390                 1395             


Glu Leu  Ala Gln Val Arg Gly  Ser Ser Val Pro Ile  Gly Tyr Pro 
    1400                 1405                 1410             


Val Trp  Asn Thr Gly Leu Arg  Ile Leu Asp Ala Met  Met His Pro 
    1415                 1420                 1425             


Val Pro  Pro Gly Val Ala Gly  Asp Leu Tyr Leu Thr  Gly Ile Gln 
    1430                 1435                 1440             


Leu Ala  Gln Gly Tyr Leu Gly  Arg Pro Asp Leu Thr  Ala Ser Arg 
    1445                 1450                 1455             


Phe Ile  Ala Asp Pro Phe Ala  Pro Gly Glu Arg Met  Tyr Arg Thr 
    1460                 1465                 1470             


Gly Asp  Val Ala Arg Trp Leu  Asp Asn Gly Ala Val  Glu Tyr Leu 
    1475                 1480                 1485             


Gly Arg  Ser Asp Asp Gln Leu  Lys Ile Arg Gly Gln  Arg Ile Glu 
    1490                 1495                 1500             


Leu Gly  Glu Ile Asp Arg Val  Met Gln Ala Leu Pro  Asp Val Glu 
    1505                 1510                 1515             


Gln Ala  Val Ala Ser Cys Ala  Ile Ala Arg Glu Asp  Ile Pro Gly 
    1520                 1525                 1530             


Asn Lys  His Leu Val Ala Tyr  Ile Val Pro Gln Glu  Glu Gln Thr 
    1535                 1540                 1545             


Cys Thr  Glu Arg Ser Arg Ser  Thr Leu Thr Val Ser  Phe Val Arg 
    1550                 1555                 1560             


Ser Phe  Leu Lys Glu Lys Leu  Pro Glu Tyr Met Val  Pro Ser Ala 
    1565                 1570                 1575             


Ile Val  Ile Leu Asp Ala Leu  Pro Leu Thr Pro Asn  Gly Lys Leu 
    1580                 1585                 1590             


Asp Arg  Arg Ala Leu Pro Ala  Pro Asp Leu His Ser  Gln Leu Glu 
    1595                 1600                 1605             


Thr Ile  Ile Ala Ala Ala Phe  Ser Ser Leu Leu Gly  Cys Asp Val 
    1610                 1615                 1620             


Gln Asp  Ala Asp Ala Asp Phe  Phe Ala Leu Gly Gly  His Ser Leu 
    1625                 1630                 1635             


Leu Ala  Met Lys Leu Ala Ala  Gln Leu Ser Arg Gln  Val Ala Arg 
    1640                 1645                 1650             


Gln Val  Thr Pro Gly Gln Val  Met Val Ala Ser Thr  Val Ala Lys 
    1655                 1660                 1665             


Leu Ala  Thr Ile Ile Asp Ala  Glu Leu Asp Lys Tyr  Val Ala Pro 
    1670                 1675                 1680             


Arg Asn  Pro Ile Leu Ala Ser  Ala Arg Ala Pro Arg  Asp Val Arg 
    1685                 1690                 1695             


Gln Thr  Ala His Ala Asp Ala  Ala Glu Pro Ala Gly  Asp Asp Gly 
    1700                 1705                 1710             


Leu Gln  His Leu Pro Leu Val  Ala Ala Gln Pro Gly  Ile Trp Met 
    1715                 1720                 1725             


Ala Glu  Lys Leu Ser Glu Leu  Pro Ser Ala Trp Ser  Val Ala His 
    1730                 1735                 1740             


Tyr Val  Glu Leu Thr Gly Glu  Val Asp Ser Pro Leu  Leu Ala Arg 
    1745                 1750                 1755             


Ala Val  Val Ala Gly Leu Ala  Gln Ala Asp Thr Leu  Arg Met Arg 
    1760                 1765                 1770             


Phe Thr  Glu Asp Asn Gly Glu  Val Trp Gln Trp Val  Asp Asp Ala 
    1775                 1780                 1785             


Leu Thr  Phe Glu Leu Pro Glu  Ile Ile Asp Leu Arg  Thr Asn Ile 
    1790                 1795                 1800             


Asp Pro  His Gly Thr Ala Gln  Ala Leu Met Gln Ala  Asp Leu Gln 
    1805                 1810                 1815             


Gln Asp  Leu Arg Val Asp Ser  Gly Lys Pro Leu Val  Phe His Gln 
    1820                 1825                 1830             


Leu Ile  Gln Val Ala Asp Asn  Arg Trp Tyr Trp Tyr  Gln Arg Tyr 
    1835                 1840                 1845             


His His  Leu Leu Val Asp Gly  Phe Ser Phe Pro Ala  Ile Thr Arg 
    1850                 1855                 1860             


Gln Ile  Ala Asn Ile Tyr Cys  Thr Trp Leu Arg Gly  Glu Pro Thr 
    1865                 1870                 1875             


Pro Ala  Ser Pro Phe Thr Pro  Phe Ala Asp Val Val  Glu Glu Tyr 
    1880                 1885                 1890             


Gln Gln  Tyr Arg Glu Ser Glu  Ala Trp Gln Arg Asp  Ala Ala Phe 
    1895                 1900                 1905             


Trp Ala  Glu Gln Arg Arg Gln  Leu Pro Pro Pro Ala  Ser Leu Ser 
    1910                 1915                 1920             


Pro Ala  Pro Leu Pro Gly Arg  Ser Ala Ser Ala Asp  Ile Leu Arg 
    1925                 1930                 1935             


Leu Lys  Leu Glu Phe Thr Asp  Gly Glu Phe Arg Gln  Leu Ala Thr 
    1940                 1945                 1950             


Gln Leu  Ser Gly Val Gln Arg  Thr Asp Leu Ala Leu  Ala Leu Ala 
    1955                 1960                 1965             


Ala Leu  Trp Leu Gly Arg Leu  Cys Asn Arg Met Asp  Tyr Ala Ala 
    1970                 1975                 1980             


Gly Phe  Ile Phe Met Arg Arg  Leu Gly Ser Ala Ala  Leu Thr Ala 
    1985                 1990                 1995             


Thr Gly  Pro Val Leu Asn Val  Leu Pro Leu Gly Ile  His Ile Gly 
    2000                 2005                 2010             


Asn Pro  Ser Phe Ser Glu Leu  Leu Thr Arg Val Arg  Glu Val Ala 
    2015                 2020                 2025             


Leu Gly  Ala Tyr Ala His Gln  His Ile Pro Phe Glu  Met Leu Val 
    2030                 2035                 2040             


Glu Ala  Leu Gln Pro Glu Arg  Asn Leu Ser His Thr  Pro Leu Phe 
    2045                 2050                 2055             


Gln Val  Met Phe Val Leu Gln  Asn Ala Pro Ala Ser  Gln Leu Glu 
    2060                 2065                 2070             


Leu Thr  Gly Ile Thr Ala Asn  Pro Ile Lys Val Lys  Ser Thr Thr 
    2075                 2080                 2085             


Thr Lys  Phe Asp Leu Thr Leu  Ile Met Gln Asn Thr  Ala Ser Gly 
    2090                 2095                 2100             


Leu Val  Gly Val Trp Glu Tyr  Asn Thr Asp Leu Phe  Asp Ala Ser 
    2105                 2110                 2115             


Thr Ile  Glu Arg Met Thr Gly  His Phe Val Thr Leu  Leu Glu Gly 
    2120                 2125                 2130             


Val Ile  Ala Asn Pro Gln Gln  Pro Ile Ser Gln Leu  Pro Ile Leu 
    2135                 2140                 2145             


Thr Thr  Val Glu Gln Gln Gln  Leu Leu Val Glu Trp  Asn Asn Thr 
    2150                 2155                 2160             


Gln Thr  Asp Tyr Pro Ala Asp  Lys Cys Ile His Gln  Leu Phe Glu 
    2165                 2170                 2175             


Glu Gln  Val Glu Arg Thr Pro  Asp Ala Val Ala Val  Val Phe Gly 
    2180                 2185                 2190             


Asn Gln  Gln Leu Ser Tyr Arg  Glu Met Arg Glu Gln  Val Val Ala 
    2195                 2200                 2205             


Leu Ala  Asn Leu Leu Arg Glu  Arg Gly Val Lys Pro  Gly Asp Ser 
    2210                 2215                 2220             


Val Ala  Val Ala Leu Pro Arg  Ser Val Phe Leu Thr  Leu Ala Leu 
    2225                 2230                 2235             


His Ala  Ile Val Glu Ala Gly  Ala Ala Trp Leu Pro  Leu Asp Thr 
    2240                 2245                 2250             


Gly Tyr  Pro Asp Asp Arg Leu  Lys Met Met Leu Glu  Asp Ala Arg 
    2255                 2260                 2265             


Pro Ser  Leu Leu Ile Thr Thr  Asp Asp Gln Leu Pro  Arg Phe Ser 
    2270                 2275                 2280             


Asp Val  Pro Asn Leu Thr Ser  Leu Cys Tyr Asn Ala  Pro Leu Thr 
    2285                 2290                 2295             


Pro Gln  Gly Ser Ala Pro Leu  Gln Leu Ser Gln Pro  His His Thr 
    2300                 2305                 2310             


Ala Tyr  Ile Ile Phe Thr Ser  Gly Ser Thr Gly Arg  Pro Lys Gly 
    2315                 2320                 2325             


Val Met  Val Gly Gln Thr Ala  Ile Val Asn Arg Leu  Leu Trp Met 
    2330                 2335                 2340             


Gln Asn  His Tyr Pro Leu Thr  Gly Glu Asp Val Val  Ala Gln Lys 
    2345                 2350                 2355             


Thr Pro  Cys Ser Phe Asp Val  Ser Val Trp Glu Phe  Phe Trp Pro 
    2360                 2365                 2370             


Phe Ile  Ala Gly Ala Lys Leu  Val Met Ala Glu Pro  Glu Ala His 
    2375                 2380                 2385             


Arg Asp  Pro Leu Ala Met Gln  Gln Phe Phe Ala Glu  Tyr Gly Val 
    2390                 2395                 2400             


Thr Thr  Thr His Phe Val Pro  Ser Met Leu Ala Ala  Phe Val Ala 
    2405                 2410                 2415             


Ser Leu  Thr Pro Gln Thr Ala  Arg Gln Ser Cys Ala  Thr Leu Lys 
    2420                 2425                 2430             


Gln Val  Phe Cys Ser Gly Glu  Ala Leu Pro Ala Asp  Leu Cys Arg 
    2435                 2440                 2445             


Glu Trp  Gln Gln Leu Thr Gly  Ala Pro Leu His Asn  Leu Tyr Gly 
    2450                 2455                 2460             


Pro Thr  Glu Ala Ala Val Asp  Val Ser Trp Tyr Pro  Ala Phe Gly 
    2465                 2470                 2475             


Glu Glu  Leu Ala Gln Val Arg  Gly Ser Ser Val Pro  Ile Gly Tyr 
    2480                 2485                 2490             


Pro Val  Trp Asn Thr Gly Leu  Arg Ile Leu Asp Ala  Met Met His 
    2495                 2500                 2505             


Pro Val  Pro Pro Gly Val Ala  Gly Asp Leu Tyr Leu  Thr Gly Ile 
    2510                 2515                 2520             


Gln Leu  Ala Gln Gly Tyr Leu  Gly Arg Pro Asp Leu  Thr Ala Ser 
    2525                 2530                 2535             


Arg Phe  Ile Ala Asp Pro Phe  Ala Pro Gly Glu Arg  Met Tyr Arg 
    2540                 2545                 2550             


Thr Gly  Asp Val Ala Arg Trp  Leu Asp Asn Gly Ala  Val Glu Tyr 
    2555                 2560                 2565             


Leu Gly  Arg Ser Asp Asp Gln  Leu Lys Ile Arg Gly  Gln Arg Ile 
    2570                 2575                 2580             


Glu Leu  Gly Glu Ile Asp Arg  Val Met Gln Ala Leu  Pro Asp Val 
    2585                 2590                 2595             


Glu Gln  Ala Val Ala Ser Cys  Ala Ile Ala Arg Glu  Asp Ile Pro 
    2600                 2605                 2610             


Gly Asn  Lys His Leu Val Ala  Tyr Ile Val Pro Gln  Glu Glu Gln 
    2615                 2620                 2625             


Thr Cys  Thr Glu Arg Ser Arg  Ser Thr Leu Thr Val  Ser Phe Val 
    2630                 2635                 2640             


Arg Ser  Phe Leu Lys Glu Lys  Leu Pro Glu Tyr Met  Val Pro Ser 
    2645                 2650                 2655             


Ala Ile  Val Ile Leu Asp Ala  Leu Pro Leu Thr Pro  Asn Gly Lys 
    2660                 2665                 2670             


Leu Asp  Arg Arg Ala Leu Pro  Ala Pro Asp Leu His  Ser Gln Leu 
    2675                 2680                 2685             


Glu Thr  Ile Ile Ala Ala Ala  Phe Ser Ser Leu Leu  Gly Cys Asp 
    2690                 2695                 2700             


Val Gln  Asp Ala Asp Ala Asp  Phe Phe Ala Leu Gly  Gly His Ser 
    2705                 2710                 2715             


Leu Leu  Ala Met Lys Leu Ala  Ala Gln Leu Ser Arg  Gln Val Ala 
    2720                 2725                 2730             


Arg Gln  Val Thr Pro Gly Gln  Val Met Val Ala Ser  Thr Val Ala 
    2735                 2740                 2745             


Lys Leu  Ala Thr Ile Ile Asp  Ala Glu Leu Asp Lys  Tyr Val Ala 
    2750                 2755                 2760             


Pro Arg  Asn Pro Ile Thr Ser  Gly Glu Asp Asn Pro  Ile Pro Leu 
    2765                 2770                 2775             


Cys Gln  Gly Asp Gly Glu Glu  Met Ser Thr Trp Leu  Arg Arg Phe 
    2780                 2785                 2790             


Gly Pro  Pro Val Glu His Arg  Ala Arg Leu Val Cys  Phe Pro His 
    2795                 2800                 2805             


Ala Gly  Ala Ala Ala Asp Ser  Tyr Leu Asp Leu Ala  Arg Ala Leu 
    2810                 2815                 2820             


Ala Pro  Glu Ile Asp Val His  Ala Val Gln Tyr Pro  Gly Arg Gln 
    2825                 2830                 2835             


Asp Arg  Arg Asp Glu Glu Pro  Leu Gly Thr Ala Gly  Glu Ile Ala 
    2840                 2845                 2850             


Asp Glu  Val Ala Ala Val Leu  Arg Ala Ser Gly Gly  Asp Gly Pro 
    2855                 2860                 2865             


Phe Ala  Leu Phe Gly His Ser  Met Gly Ala Leu Ile  Ala Tyr Glu 
    2870                 2875                 2880             


Thr Ala  Arg Arg Leu Glu Arg  Glu Pro Gly Gly Gly  Pro Leu Arg 
    2885                 2890                 2895             


Leu Phe  Val Ser Gly Gln Thr  Ala Pro Arg Val His  Glu Arg Arg 
    2900                 2905                 2910             


Thr Asp  Leu Pro Gly Asp Asp  Gly Leu Val Asp Glu  Leu Arg Arg 
    2915                 2920                 2925             


Leu Gly  Thr Ser Glu Ala Ala  Leu Ala Asp Glu Ala  Leu Leu Ala 
    2930                 2935                 2940             


Met Ser  Leu Pro Val Leu Arg  Ala Asp Tyr Arg Val  Leu Arg Ser 
    2945                 2950                 2955             


Tyr Ala  Trp Ala Asp Gly Pro  Pro Leu Arg Ala Gly  Ile Thr Ala 
    2960                 2965                 2970             


Leu Cys  Gly Asp Ala Asp Pro  Leu Thr Ala Thr Gly  Asp Ala Glu 
    2975                 2980                 2985             


Arg Trp  Leu Gln His Ser Val  Ile Pro Gly Arg Thr  Arg Thr Phe 
    2990                 2995                 3000             


Pro Gly  Gly His Phe Tyr Leu  Gly Glu Gln Val Thr  Glu Val Ala 
    3005                 3010                 3015             


Gly Ala  Val Arg Arg Asp Leu  Leu Arg Ala Gly Leu  Ala Gly 
    3020                 3025                 3030         


