                         SEQUENCE LISTING

<110>  QIAGEN Waltham Inc.
 
<120>  POLYMERASE ENZYME FROM PYROCOCCUS FURIOSUS

<130>  37578.0052P1

<150>  62/458,397
<151>  2017-02-13

<150>  EP17160396
<151>  2017-03-10

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  775
<212>  PRT
<213>  Pyrococcus furiosus

<400>  1

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  2
<211>  775
<212>  PRT
<213>  Pyrococcus furiosus

<400>  2

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Ala Ile Ala Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Ser Gly Ser Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Leu Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  3
<211>  2328
<212>  PRT
<213>  Pyrococcus furiosus

<400>  3

Ala Thr Gly Ala Thr Thr Cys Thr Gly Gly Ala Thr Gly Thr Gly Gly 
1               5                   10                  15      


Ala Thr Thr Ala Cys Ala Thr Thr Ala Cys Cys Gly Ala Ala Gly Ala 
            20                  25                  30          


Ala Gly Gly Cys Ala Ala Ala Cys Cys Gly Gly Thr Thr Ala Thr Thr 
        35                  40                  45              


Cys Gly Cys Cys Thr Gly Thr Thr Cys Ala Ala Ala Ala Ala Ala Gly 
    50                  55                  60                  


Ala Ala Ala Ala Cys Gly Gly Cys Ala Ala Ala Thr Thr Cys Ala Ala 
65                  70                  75                  80  


Ala Ala Thr Cys Gly Ala Gly Cys Ala Cys Gly Ala Thr Cys Gly Thr 
                85                  90                  95      


Ala Cys Cys Thr Thr Thr Cys Gly Thr Cys Cys Gly Thr Ala Thr Ala 
            100                 105                 110         


Thr Cys Thr Ala Thr Gly Cys Ala Cys Thr Gly Cys Thr Gly Cys Gly 
        115                 120                 125             


Thr Gly Ala Thr Gly Ala Thr Ala Gly Cys Ala Ala Ala Ala Thr Cys 
    130                 135                 140                 


Gly Ala Ala Gly Ala Ala Gly Thr Gly Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Thr Cys Ala Cys Gly Gly Gly Thr Gly Ala Ala Cys Gly Cys Cys Ala 
                165                 170                 175     


Thr Gly Gly Cys Ala Ala Ala Ala Thr Thr Gly Thr Thr Cys Gly Thr 
            180                 185                 190         


Ala Thr Thr Gly Thr Thr Gly Ala Thr Gly Thr Cys Gly Ala Ala Ala 
        195                 200                 205             


Ala Ala Gly Thr Cys Gly Ala Gly Ala Ala Ala Ala Ala Ala Thr Thr 
    210                 215                 220                 


Cys Cys Thr Gly Gly Gly Thr Ala Ala Ala Cys Cys Gly Ala Thr Thr 
225                 230                 235                 240 


Ala Cys Cys Gly Thr Gly Thr Gly Gly Ala Ala Ala Cys Thr Gly Thr 
                245                 250                 255     


Ala Thr Cys Thr Gly Gly Ala Ala Cys Ala Thr Cys Cys Gly Cys Ala 
            260                 265                 270         


Gly Gly Ala Thr Gly Thr Gly Cys Cys Gly Ala Cys Cys Ala Thr Thr 
        275                 280                 285             


Cys Gly Thr Gly Ala Ala Ala Ala Ala Gly Thr Thr Cys Gly Thr Gly 
    290                 295                 300                 


Ala Ala Cys Ala Thr Cys Cys Gly Gly Cys Ala Gly Thr Gly Gly Thr 
305                 310                 315                 320 


Thr Gly Ala Thr Ala Thr Cys Thr Thr Thr Gly Ala Ala Thr Ala Thr 
                325                 330                 335     


Gly Ala Thr Ala Thr Thr Cys Cys Gly Thr Thr Cys Gly Cys Cys Ala 
            340                 345                 350         


Ala Ala Cys Gly Cys Thr Ala Cys Cys Thr Gly Ala Thr Thr Gly Ala 
        355                 360                 365             


Thr Ala Ala Ala Gly Gly Thr Cys Thr Gly Ala Thr Thr Cys Cys Gly 
    370                 375                 380                 


Ala Thr Gly Gly Ala Ala Gly Gly Thr Gly Ala Ala Gly Ala Ala Gly 
385                 390                 395                 400 


Ala Ala Cys Thr Gly Ala Ala Ala Ala Thr Thr Cys Thr Gly Gly Cys 
                405                 410                 415     


Ala Thr Thr Thr Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Cys Cys 
            420                 425                 430         


Cys Thr Gly Thr Ala Thr Cys Ala Thr Gly Ala Ala Gly Gly Cys Gly 
        435                 440                 445             


Ala Ala Gly Ala Ala Thr Thr Thr Gly Gly Thr Ala Ala Ala Gly Gly 
    450                 455                 460                 


Thr Cys Cys Gly Ala Thr Thr Ala Thr Cys Ala Thr Gly Ala Thr Cys 
465                 470                 475                 480 


Ala Gly Cys Thr Ala Thr Gly Cys Cys Gly Ala Thr Gly Ala Ala Ala 
                485                 490                 495     


Ala Thr Gly Ala Gly Gly Cys Cys Ala Ala Ala Gly Thr Thr Ala Thr 
            500                 505                 510         


Thr Ala Cys Cys Thr Gly Gly Ala Ala Ala Ala Ala Cys Ala Thr Cys 
        515                 520                 525             


Gly Ala Thr Cys Thr Gly Cys Cys Gly Thr Ala Thr Gly Thr Thr Gly 
    530                 535                 540                 


Ala Ala Gly Thr Thr Gly Thr Thr Ala Gly Cys Ala Gly Cys Gly Ala 
545                 550                 555                 560 


Ala Cys Gly Thr Gly Ala Ala Ala Thr Gly Ala Thr Thr Ala Ala Ala 
                565                 570                 575     


Cys Gly Thr Thr Thr Thr Cys Thr Gly Cys Gly Cys Ala Thr Cys Ala 
            580                 585                 590         


Thr Cys Cys Gly Cys Gly Ala Ala Ala Ala Ala Gly Ala Thr Cys Cys 
        595                 600                 605             


Gly Gly Ala Thr Ala Thr Cys Ala Thr Thr Gly Thr Gly Ala Cys Cys 
    610                 615                 620                 


Thr Ala Thr Ala Ala Cys Gly Gly Cys Gly Ala Thr Ala Gly Cys Thr 
625                 630                 635                 640 


Thr Thr Gly Ala Thr Thr Thr Thr Cys Cys Gly Thr Ala Thr Cys Thr 
                645                 650                 655     


Gly Gly Cys Ala Ala Ala Ala Cys Gly Thr Gly Cys Ala Gly Ala Ala 
            660                 665                 670         


Ala Ala Ala Cys Thr Gly Gly Gly Thr Ala Thr Thr Ala Ala Ala Cys 
        675                 680                 685             


Thr Gly Ala Cys Cys Ala Thr Thr Gly Gly Thr Cys Gly Thr Gly Ala 
    690                 695                 700                 


Thr Gly Gly Thr Ala Gly Cys Gly Ala Ala Cys Cys Gly Ala Ala Ala 
705                 710                 715                 720 


Ala Thr Gly Cys Ala Gly Cys Gly Thr Ala Thr Thr Gly Gly Thr Gly 
                725                 730                 735     


Ala Thr Ala Thr Gly Ala Cys Cys Gly Cys Ala Gly Thr Thr Gly Ala 
            740                 745                 750         


Ala Gly Thr Thr Ala Ala Ala Gly Gly Thr Cys Gly Cys Ala Thr Thr 
        755                 760                 765             


Cys Ala Cys Thr Thr Thr Gly Ala Thr Cys Thr Gly Thr Ala Cys Cys 
    770                 775                 780                 


Ala Thr Gly Thr Thr Ala Thr Thr Ala Cys Cys Cys Gly Cys Ala Cys 
785                 790                 795                 800 


Cys Ala Thr Thr Ala Ala Thr Cys Thr Gly Cys Cys Gly Ala Cys Cys 
                805                 810                 815     


Thr Ala Thr Ala Cys Cys Cys Thr Gly Gly Ala Ala Gly Cys Ala Gly 
            820                 825                 830         


Thr Thr Thr Ala Thr Gly Ala Ala Gly Cys Ala Ala Thr Thr Thr Thr 
        835                 840                 845             


Cys Gly Gly Cys Ala Ala Ala Cys Cys Gly Ala Ala Ala Gly Ala Ala 
    850                 855                 860                 


Ala Ala Ala Gly Thr Gly Thr Ala Thr Gly Cys Gly Gly Ala Thr Gly 
865                 870                 875                 880 


Ala Ala Ala Thr Thr Gly Cys Ala Ala Ala Ala Gly Cys Ala Thr Gly 
                885                 890                 895     


Gly Gly Ala Ala Ala Gly Cys Gly Gly Thr Gly Ala Ala Ala Ala Thr 
            900                 905                 910         


Cys Thr Gly Gly Ala Ala Cys Gly Thr Gly Thr Thr Gly Cys Ala Ala 
        915                 920                 925             


Ala Ala Thr Ala Thr Ala Gly Cys Ala Thr Gly Gly Ala Ala Gly Ala 
    930                 935                 940                 


Thr Gly Cys Ala Ala Ala Ala Gly Cys Cys Ala Cys Cys Thr Ala Thr 
945                 950                 955                 960 


Gly Ala Ala Cys Thr Gly Gly Gly Thr Ala Ala Ala Gly Ala Ala Thr 
                965                 970                 975     


Thr Thr Cys Thr Gly Cys Cys Gly Ala Thr Gly Gly Ala Ala Ala Thr 
            980                 985                 990         


Thr Cys Ala Gly Cys Thr Gly Ala  Gly Cys Cys Gly Thr  Cys Thr Gly 
        995                 1000                 1005             


Gly Thr  Thr Gly Gly Thr Cys  Ala Gly Cys Cys Gly  Cys Thr Gly 
    1010                 1015                 1020             


Thr Gly  Gly Gly Ala Thr Gly  Thr Thr Ala Gly Cys  Cys Gly Thr 
    1025                 1030                 1035             


Ala Gly  Cys Ala Gly Cys Ala  Cys Cys Gly Gly Thr  Ala Ala Thr 
    1040                 1045                 1050             


Cys Thr  Gly Gly Thr Thr Gly  Ala Ala Thr Gly Gly  Thr Thr Thr 
    1055                 1060                 1065             


Cys Thr  Gly Cys Thr Gly Cys  Gly Thr Ala Ala Ala  Gly Cys Cys 
    1070                 1075                 1080             


Thr Ala  Thr Gly Ala Ala Cys  Gly Thr Ala Ala Thr  Gly Ala Ala 
    1085                 1090                 1095             


Gly Thr  Thr Gly Cys Ala Cys  Cys Gly Ala Ala Thr  Ala Ala Ala 
    1100                 1105                 1110             


Cys Cys  Gly Ala Gly Cys Gly  Ala Ala Gly Ala Ala  Gly Ala Ala 
    1115                 1120                 1125             


Thr Ala  Thr Cys Ala Gly Cys  Gly Thr Cys Gly Thr  Cys Thr Gly 
    1130                 1135                 1140             


Cys Gly  Thr Gly Ala Ala Ala  Gly Cys Thr Ala Thr  Ala Cys Cys 
    1145                 1150                 1155             


Gly Gly  Thr Gly Gly Thr Thr  Thr Thr Gly Thr Thr  Ala Ala Ala 
    1160                 1165                 1170             


Gly Ala  Ala Cys Cys Gly Gly  Ala Ala Ala Ala Ala  Gly Gly Thr 
    1175                 1180                 1185             


Cys Thr  Gly Thr Gly Gly Gly  Ala Gly Ala Ala Thr  Ala Thr Cys 
    1190                 1195                 1200             


Gly Thr  Thr Thr Ala Thr Cys  Thr Gly Gly Ala Thr  Thr Thr Thr 
    1205                 1210                 1215             


Cys Gly  Thr Gly Cys Ala Ala  Gly Cys Gly Gly Thr  Ala Gly Cys 
    1220                 1225                 1230             


Ala Gly  Cys Ala Thr Thr Ala  Thr Thr Ala Thr Cys  Ala Cys Cys 
    1235                 1240                 1245             


Cys Ala  Thr Ala Ala Thr Gly  Thr Thr Ala Gly Thr  Cys Cys Gly 
    1250                 1255                 1260             


Gly Ala  Thr Ala Cys Cys Cys  Thr Gly Ala Ala Thr  Cys Thr Gly 
    1265                 1270                 1275             


Gly Ala  Ala Gly Gly Cys Thr  Gly Thr Ala Ala Ala  Ala Ala Cys 
    1280                 1285                 1290             


Thr Ala  Thr Gly Ala Thr Ala  Thr Thr Gly Cys Ala  Cys Cys Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Thr Thr Gly  Gly Cys Cys Ala Cys  Ala Ala Ala 
    1310                 1315                 1320             


Thr Thr  Cys Thr Gly Thr Ala  Ala Ala Gly Ala Thr  Ala Thr Thr 
    1325                 1330                 1335             


Cys Cys  Gly Gly Gly Thr Thr  Thr Thr Ala Thr Thr  Cys Cys Gly 
    1340                 1345                 1350             


Ala Gly  Cys Cys Thr Gly Cys  Thr Gly Gly Gly Thr  Cys Ala Thr 
    1355                 1360                 1365             


Cys Thr  Gly Cys Thr Gly Gly  Ala Ala Gly Ala Ala  Cys Gly Thr 
    1370                 1375                 1380             


Cys Ala  Ala Ala Ala Ala Ala  Thr Cys Ala Ala Ala  Ala Cys Cys 
    1385                 1390                 1395             


Ala Ala  Ala Ala Thr Gly Ala  Ala Ala Gly Ala Ala  Ala Cys Cys 
    1400                 1405                 1410             


Cys Ala  Gly Gly Ala Thr Cys  Cys Gly Ala Thr Cys  Gly Ala Ala 
    1415                 1420                 1425             


Ala Ala  Ala Ala Thr Cys Cys  Thr Gly Cys Thr Gly  Gly Ala Thr 
    1430                 1435                 1440             


Thr Ala  Thr Cys Gly Thr Cys  Ala Gly Ala Ala Ala  Cys Thr Gly 
    1445                 1450                 1455             


Ala Thr  Cys Ala Ala Ala Cys  Thr Gly Cys Thr Gly  Gly Cys Cys 
    1460                 1465                 1470             


Ala Ala  Thr Ala Gly Cys Thr  Thr Cys Thr Ala Thr  Gly Gly Thr 
    1475                 1480                 1485             


Thr Ala  Thr Thr Ala Thr Gly  Gly Cys Thr Ala Thr  Gly Cys Cys 
    1490                 1495                 1500             


Ala Ala  Ala Gly Cys Ala Cys  Gly Cys Thr Gly Gly  Thr Ala Thr 
    1505                 1510                 1515             


Thr Gly  Thr Ala Ala Ala Gly  Ala Ala Thr Gly Thr  Gly Cys Ala 
    1520                 1525                 1530             


Gly Ala  Ala Ala Gly Cys Gly  Thr Thr Ala Cys Cys  Gly Cys Ala 
    1535                 1540                 1545             


Thr Gly  Gly Gly Gly Thr Cys  Gly Cys Ala Ala Ala  Thr Ala Thr 
    1550                 1555                 1560             


Ala Thr  Cys Gly Ala Ala Cys  Thr Gly Gly Thr Thr  Thr Gly Gly 
    1565                 1570                 1575             


Ala Ala  Ala Gly Ala Ala Cys  Thr Gly Gly Ala Ala  Gly Ala Gly 
    1580                 1585                 1590             


Ala Ala  Ala Thr Thr Thr Gly  Gly Cys Thr Thr Cys  Ala Ala Ala 
    1595                 1600                 1605             


Gly Thr  Gly Cys Thr Gly Thr  Ala Thr Ala Thr Thr  Gly Ala Thr 
    1610                 1615                 1620             


Ala Cys  Cys Gly Ala Thr Gly  Gly Thr Cys Thr Gly  Thr Ala Thr 
    1625                 1630                 1635             


Gly Cys  Ala Ala Cys Cys Ala  Thr Thr Cys Cys Gly  Gly Gly Thr 
    1640                 1645                 1650             


Gly Gly  Thr Gly Ala Ala Ala  Gly Cys Gly Ala Ala  Gly Ala Gly 
    1655                 1660                 1665             


Ala Thr  Thr Ala Ala Ala Ala  Ala Ala Ala Ala Ala  Gly Cys Cys 
    1670                 1675                 1680             


Cys Thr  Gly Gly Ala Ala Thr  Thr Thr Gly Thr Gly  Ala Ala Ala 
    1685                 1690                 1695             


Thr Ala  Cys Ala Thr Cys Ala  Ala Cys Ala Gly Cys  Ala Ala Ala 
    1700                 1705                 1710             


Cys Thr  Gly Cys Cys Ala Gly  Gly Cys Cys Thr Gly  Cys Thr Gly 
    1715                 1720                 1725             


Gly Ala  Ala Cys Thr Gly Gly  Ala Ala Thr Ala Thr  Gly Ala Ala 
    1730                 1735                 1740             


Gly Gly  Thr Thr Thr Cys Thr  Ala Thr Ala Ala Ala  Cys Gly Cys 
    1745                 1750                 1755             


Gly Gly  Thr Thr Thr Cys Thr  Thr Thr Gly Thr Gly  Ala Cys Cys 
    1760                 1765                 1770             


Ala Ala  Ala Ala Ala Ala Cys  Gly Cys Thr Ala Thr  Gly Cys Ala 
    1775                 1780                 1785             


Gly Thr  Gly Ala Thr Thr Gly  Ala Thr Gly Ala Ala  Gly Ala Gly 
    1790                 1795                 1800             


Gly Gly  Thr Ala Ala Ala Gly  Thr Gly Ala Thr Thr  Ala Cys Cys 
    1805                 1810                 1815             


Cys Gly  Thr Gly Gly Thr Cys  Thr Gly Gly Ala Ala  Ala Thr Thr 
    1820                 1825                 1830             


Gly Thr  Gly Cys Gly Thr Cys  Gly Thr Gly Ala Thr  Thr Gly Gly 
    1835                 1840                 1845             


Ala Gly  Thr Gly Ala Ala Ala  Thr Cys Gly Cys Cys  Ala Ala Ala 
    1850                 1855                 1860             


Gly Ala  Ala Ala Cys Ala Cys  Ala Gly Gly Cys Ala  Cys Gly Thr 
    1865                 1870                 1875             


Gly Thr  Thr Cys Thr Gly Gly  Ala Ala Ala Cys Ala  Ala Thr Thr 
    1880                 1885                 1890             


Cys Thr  Gly Ala Ala Ala Cys  Ala Thr Gly Gly Thr  Gly Ala Thr 
    1895                 1900                 1905             


Gly Thr  Thr Gly Ala Ala Gly  Ala Ala Gly Cys Cys  Gly Thr Gly 
    1910                 1915                 1920             


Cys Gly  Thr Ala Thr Cys Gly  Thr Thr Ala Ala Ala  Gly Ala Ala 
    1925                 1930                 1935             


Gly Thr  Thr Ala Thr Cys Cys  Ala Gly Ala Ala Ala  Cys Thr Gly 
    1940                 1945                 1950             


Gly Cys  Cys Ala Ala Cys Thr  Ala Thr Gly Ala Ala  Ala Thr Thr 
    1955                 1960                 1965             


Cys Cys  Gly Cys Cys Thr Gly  Ala Ala Ala Ala Ala  Cys Thr Gly 
    1970                 1975                 1980             


Gly Cys  Ala Ala Thr Cys Thr  Ala Thr Gly Ala Gly  Cys Ala Gly 
    1985                 1990                 1995             


Ala Thr  Thr Ala Cys Cys Cys  Gly Thr Cys Cys Gly  Cys Thr Gly 
    2000                 2005                 2010             


Cys Ala  Thr Gly Ala Ala Thr  Ala Thr Ala Ala Ala  Gly Cys Ala 
    2015                 2020                 2025             


Ala Thr  Thr Gly Gly Thr Cys  Cys Gly Cys Ala Thr  Gly Thr Thr 
    2030                 2035                 2040             


Gly Cys  Cys Gly Thr Thr Gly  Cys Ala Ala Ala Ala  Ala Ala Ala 
    2045                 2050                 2055             


Cys Thr  Gly Gly Cys Thr Gly  Cys Ala Ala Ala Ala  Gly Gly Cys 
    2060                 2065                 2070             


Gly Thr  Thr Ala Ala Ala Ala  Thr Cys Ala Ala Ala  Cys Cys Gly 
    2075                 2080                 2085             


Gly Gly  Thr Ala Thr Gly Gly  Thr Gly Ala Thr Thr  Gly Gly Thr 
    2090                 2095                 2100             


Thr Ala  Thr Ala Thr Thr Gly  Thr Thr Cys Thr Gly  Cys Gly Thr 
    2105                 2110                 2115             


Gly Gly  Thr Gly Ala Thr Gly  Gly Thr Cys Cys Gly  Ala Thr Thr 
    2120                 2125                 2130             


Thr Cys  Ala Ala Ala Thr Cys  Gly Thr Gly Cys Ala  Ala Thr Thr 
    2135                 2140                 2145             


Cys Thr  Gly Gly Cys Cys Gly  Ala Ala Gly Ala Ala  Thr Ala Cys 
    2150                 2155                 2160             


Gly Ala  Thr Cys Cys Gly Ala  Ala Ala Ala Ala Ala  Cys Ala Cys 
    2165                 2170                 2175             


Ala Ala  Ala Thr Ala Thr Gly  Ala Cys Gly Cys Cys  Gly Ala Gly 
    2180                 2185                 2190             


Thr Ala  Thr Thr Ala Thr Ala  Thr Cys Gly Ala Ala  Ala Ala Thr 
    2195                 2200                 2205             


Cys Ala  Gly Gly Thr Thr Cys  Thr Gly Cys Cys Thr  Gly Cys Ala 
    2210                 2215                 2220             


Gly Thr  Thr Cys Thr Gly Cys  Gly Thr Ala Thr Thr  Cys Thr Gly 
    2225                 2230                 2235             


Gly Ala  Ala Gly Gly Thr Thr  Thr Thr Gly Gly Thr  Thr Ala Thr 
    2240                 2245                 2250             


Cys Gly  Cys Ala Ala Ala Gly  Ala Ala Gly Ala Thr  Cys Thr Gly 
    2255                 2260                 2265             


Cys Gly  Thr Thr Ala Thr Cys  Ala Gly Ala Ala Ala  Ala Cys Cys 
    2270                 2275                 2280             


Cys Gly  Thr Cys Ala Gly Gly  Thr Gly Gly Gly Thr  Cys Thr Gly 
    2285                 2290                 2295             


Ala Cys  Cys Ala Gly Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Thr 
    2300                 2305                 2310             


Ala Thr  Cys Ala Ala Ala Ala  Ala Ala Ala Gly Cys  Thr Ala Ala 
    2315                 2320                 2325             


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  4
ccactgcagg ctgtaagt                                                     18


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  template


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  5
gactanactt acagcctgca gtgg                                              24


