			SEQUENCE LISTING

<110> CODEXIS, INC.
      CHNG, CHINPING
      HALLOWS, WILLIAM CASEY
      AGARD, NICHOLAS J.
      ALVIZO, OSCAR
      DELLAS, NIKKI
      HUISMAN, GJALT W.
      NICOLS, JOHN JOSEPH
 
<120> ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
 
<130> CX7-159USP1
 
<140> TO BE ASSIGNED
<141> 2017-02-13
 
 
<160> 12
 
<210> 1
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Anabaena variabilis PAL
 
<400> 1
atgaaaaccc tgagccaggc acagagcaaa accagcagcc agcagtttag ctttaccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgcacgt 120
gttgcccgta atggcaccct ggttagcctg accaataata ccgatattct gcagggtatt 180
caggccagct gtgattatat caataatgca gttgaaagcg gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gcaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactgc gtcagctgaa tctgagtccg ctgaccctgc tgccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgattagcct gctggccaat agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atcgtgatca tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc tgggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctgct gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacagttt aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgat atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcctgtc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
cagaaaccga cctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgtgtctgca t                                           1701

 
<210> 2
<211> 567
<212> PRT
<213> Anabaena variabilis PAL
 
<220>
<223> Anabaena variabilis PAL
 
<400> 2
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Phe 
1               5                   10                  15      
Ser Phe Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Ala Arg Val Ala Arg Asn Gly Thr Leu Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Thr Asp Ile Leu Gln Gly Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Ser Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Ala Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Ser Pro Leu Thr Leu Leu Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             
Ala Asn Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Arg Asp His Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Leu Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Phe Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Cys Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Gln Lys Pro Thr Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Cys Leu His                                     
                565                                             

 
<210> 3
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 3
atgaaaaccc tgagtcaggc acagagcaaa accagcagcc agcagtttag ccataccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgtacgt 120
gttgcccgta atggcaccgc ggttagcctg accaataata aagatattct gcagcgtatt 180
caggccagct gtgattatat caataatgca gttgaaaaag gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gtaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactgc gtcagctgaa tctgagtccg ctgaccctgc agccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgattagcct gctggccggt agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atatggatgg tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc tgggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctggt gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacagttt aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgat atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcccagc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
aaaaaaccga gctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgccgctgca t                                           1701

 
<210> 4
<211> 567
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 4
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Phe 
1               5                   10                  15      
Ser His Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Val Arg Val Ala Arg Asn Gly Thr Ala Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Lys Asp Ile Leu Gln Arg Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Lys Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Val Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Ser Pro Leu Thr Leu Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             
Ala Gly Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Met Asp Gly Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Val Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Phe Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Gln Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Lys Lys Pro Ser Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Pro Leu His                                     
                565                                             

 
<210> 5
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 5
atgaaaaccc tgagtcaggc acagagcaaa accagcagcc agcagtttag ccataccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgtacgt 120
gttgcccgta atggcaccgc ggttagcctg accaataata aagatattct gcagcgtatt 180
caggccagct gtgattatat caataatgca gttgaaaaag gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gtaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactgc gtcagctgaa tctgagtccg ctgaccctgc agccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgattagcct gctggccggt agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atatggatgg tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc tgggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctggt gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacaggca aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgat atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcccagc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
aaaaaaccga gctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgccgctgca t                                           1701

 
<210> 6
<211> 567
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 6
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Phe 
1               5                   10                  15      
Ser His Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Val Arg Val Ala Arg Asn Gly Thr Ala Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Lys Asp Ile Leu Gln Arg Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Lys Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Val Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Ser Pro Leu Thr Leu Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             
Ala Gly Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Met Asp Gly Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Val Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Ala Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Gln Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Lys Lys Pro Ser Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Pro Leu His                                     
                565                                             

 
<210> 7
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 7
atgaaaaccc tgagtcaggc acagagcaaa accagcagcc agcagtctag ccataccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgtacgt 120
gttgcccgta atggcaccgc ggttagcctg accaataata aagatattct gcagcgtatt 180
caggccagct gtgattatat caataatgca gttgaaaaag gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gtaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactgc gtcagctgaa tctgagtccg ctgaccctgc agccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgattagcct gctggccggt agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atatggatgg tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc tgggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctggt gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacaggca aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgat atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcccagc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
aaaaaaccga gctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgccgctgca t                                           1701

 
<210> 8
<211> 567
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 8
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Ser 
1               5                   10                  15      
Ser His Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Val Arg Val Ala Arg Asn Gly Thr Ala Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Lys Asp Ile Leu Gln Arg Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Lys Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Val Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Ser Pro Leu Thr Leu Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             
Ala Gly Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Met Asp Gly Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Val Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Ala Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Gln Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Lys Lys Pro Ser Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Pro Leu His                                     
                565                                             

 
<210> 9
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 9
atgaaaaccc tgagtcaggc acagagcaaa accagcagcc agcagtctag ccataccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgtacgt 120
gttgcccgta atggcaccgc ggttagcctg accaataata aagatattct gcagcgtatt 180
caggccagct gtgattatat caataatgca gttgaaaaag gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gtaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactga gacagctgaa tctgccgccg ctgaccctgc agccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgctaagcct gctggccggt agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atatggatgg tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc atggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctggt gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacaggca aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgaa atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcccagc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
aaaaaaccga gctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgccgctgca t                                           1701

 
<210> 10
<211> 567
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 10
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Ser 
1               5                   10                  15      
Ser His Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Val Arg Val Ala Arg Asn Gly Thr Ala Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Lys Asp Ile Leu Gln Arg Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Lys Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Val Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Pro Pro Leu Thr Leu Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Leu Ser Leu Leu 
        275                 280                 285             
Ala Gly Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Met Asp Gly Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe His Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Val Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Ala Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Glu Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Gln Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Lys Lys Pro Ser Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Pro Leu His                                     
                565                                             

 
<210> 11
<211> 1701
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 11
atgaaaaccc tgagtcaggc tcagagcaaa accagcagcc agcagtctag ccataccggc 60
aatagcagcg caaatgtgat tattggtaat cagaaactga ccatcaatga tgttgtacgt 120
gttgcccgta atggcaccgc ggttagcctg accaataata aagatattct gcagcgtatt 180
caggccagct gtgattatat caataatgca gttgaaaaag gtgaaccgat ttatggtgtt 240
accagcggtt ttggtggtat ggcaaatgtt gtaattagcc gtgaacaggc aagcgaactg 300
cagaccaatc tggtttggtt tctgaaaacc ggtgcaggta ataaactgcc gctggcagat 360
gttcgtgcag caatgctgct gcgtgcaaat agccacatgc gtggtgcaag cggtattcgt 420
ctggaactga ttaaacgcat ggaaatcttt ctgaatgccg gtgttacccc gtatgtttat 480
gaatttggta gcattggtgc cagcggtgat ctggttccgc tgagctatat taccggtagc 540
ctgattggcc tggacccgag ctttaaagtt gattttaatg gcaaagaaat ggacgcaccg 600
accgcactga gacagctgaa tctgccgccg ctgaccctgc agccgaaaga aggtctggca 660
atgatgaatg gcaccagcgt tatgaccggt attgcagcaa attgtgttta tgatacccag 720
attctgaccg caattgcaat gggtgttcat gcactggata ttcaggcact gaatggtaca 780
aatcagagct ttcatccgtt tatccataac agcaaaccgc atccgggtca gctgtgggca 840
gcagatcaga tgctaagcct gctggccggt agccagctgg ttcgtgatga actggatggt 900
aaacatgatt atatggatgg tgaactgatc caggatcgtt atagcctgcg ttgtctgccg 960
cagtatctgg gtccgattgt tgatggtatt agccagattg ccaaacaaat cgaaattgag 1020
attaacagcg ttaccgataa cccgctgatt gatgttgata atcaggcaag ctatcatggt 1080
ggtaattttc atggtcagta tgttggtatg ggtatggatc atctgcgcta ttatatcggt 1140
ctgctggcaa aacatctgga tgttcagatt gcactgctgg catcaccgga atttagcaat 1200
ggtctgcctc cgagtctggt gggtaatcgt gaacgtaaag ttaatatggg tctgaaaggt 1260
ctgcagattt gcggtaatag cattatgccg ctgctgacct tttatggtaa tagtattgca 1320
gatcgttttc cgacccatgc cgaacaggca aaccagaata ttaacagcca gggttatacc 1380
agcgcaaccc tggcacgtcg tagcgttgaa atttttcaga attatgttgc cattgccctg 1440
atgtttggtg ttcaggcagt tgatctgcgt acctacaaaa aaaccggtca ttatgatgca 1500
cgtgcccagc tgtcaccggc aaccgaacgt ctgtatagcg cagttcgtca tgttgttggt 1560
aaaaaaccga gctcagatcg tccgtatatt tggaatgata atgaacaggg tctggatgaa 1620
catattgcac gtattagtgc agatattgca gccggtggtg ttattgttca ggccgttcag 1680
gacattctgc cgccgctgca t                                           1701

 
<210> 12
<211> 567
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of PAL from Anabaena variabilis 
 
<400> 12
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Ser 
1               5                   10                  15      
Ser His Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          
Leu Thr Ile Asn Asp Val Val Arg Val Ala Arg Asn Gly Thr Ala Val 
        35                  40                  45              
Ser Leu Thr Asn Asn Lys Asp Ile Leu Gln Arg Ile Gln Ala Ser Cys 
    50                  55                  60                  
Asp Tyr Ile Asn Asn Ala Val Glu Lys Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  
Thr Ser Gly Phe Gly Gly Met Ala Asn Val Val Ile Ser Arg Glu Gln 
                85                  90                  95      
Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         
Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             
Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 
Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 
Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     
Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         
Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             
Pro Pro Leu Thr Leu Gln Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 
Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 
Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     
Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         
Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Leu Ser Leu Leu 
        275                 280                 285             
Ala Gly Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 
Met Asp Gly Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 
Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     
Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         
Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe His Gly Gln Tyr Val 
        355                 360                 365             
Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 
His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 
Gly Leu Pro Pro Ser Leu Val Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     
Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         
Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             
Gln Ala Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 
Ala Arg Arg Ser Val Glu Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 
Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     
His Tyr Asp Ala Arg Ala Gln Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         
Ser Ala Val Arg His Val Val Gly Lys Lys Pro Ser Ser Asp Arg Pro 
        515                 520                 525             
Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 
Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 
Asp Ile Leu Pro Pro Leu His                                     
                565                                             

