                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  MODULATION OF KALLIKREIN B1 (KLKB1) FOR TREATMENT OF HEADACHE

<130>  BIOL0314WO

<150>  62/456,520
<151>  2017-02-08

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  2252
<212>  DNA
<213>  Homo sapien

<400>  1
agaacagctt gaagaccgtt catttttaag tgacaagaga ctcacctcca agaagcaatt       60

gtgttttcag aatgatttta ttcaagcaag caacttattt catttccttg tttgctacag      120

tttcctgtgg atgtctgact caactctatg aaaacgcctt cttcagaggt ggggatgtag      180

cttccatgta caccccaaat gcccaatact gccagatgag gtgcacattc cacccaaggt      240

gtttgctatt cagttttctt ccagcaagtt caatcaatga catggagaaa aggtttggtt      300

gcttcttgaa agatagtgtt acaggaaccc tgccaaaagt acatcgaaca ggtgcagttt      360

ctggacattc cttgaagcaa tgtggtcatc aaataagtgc ttgccatcga gacatttata      420

aaggagttga tatgagagga gtcaatttta atgtgtctaa ggttagcagt gttgaagaat      480

gccaaaaaag gtgcaccagt aacattcgct gccagttttt ttcatatgcc acgcaaacat      540

ttcacaaggc agagtaccgg aacaattgcc tattaaagta cagtcccgga ggaacaccta      600

ccgctataaa ggtgctgagt aacgtggaat ctggattctc actgaagccc tgtgcccttt      660

cagaaattgg ttgccacatg aacatcttcc agcatcttgc gttctcagat gtggatgttg      720

ccagggttct cactccagat gcttttgtgt gtcggaccat ctgcacctat caccccaact      780

gcctcttctt tacattctat acaaatgtat ggaaaatcga gtcacaaaga aatgtttgtc      840

ttcttaaaac atctgaaagt ggcacaccaa gttcctctac tcctcaagaa aacaccatat      900

ctggatatag ccttttaacc tgcaaaagaa ctttacctga accctgccat tctaaaattt      960

acccgggagt tgactttgga ggagaagaat tgaatgtgac ttttgttaaa ggagtgaatg     1020

tttgccaaga gacttgcaca aagatgattc gctgtcagtt tttcacttat tctttactcc     1080

cagaagactg taaggaagag aagtgtaagt gtttcttaag attatctatg gatggttctc     1140

caactaggat tgcgtatggg acacaaggga gctctggtta ctctttgaga ttgtgtaaca     1200

ctggggacaa ctctgtctgc acaacaaaaa caagcacacg cattgttgga ggaacaaact     1260

cttcttgggg agagtggccc tggcaggtga gcctgcaggt gaagctgaca gctcagaggc     1320

acctgtgtgg agggtcactc ataggacacc agtgggtcct cactgctgcc cactgctttg     1380

atgggcttcc cctgcaggat gtttggcgca tctatagtgg cattttaaat ctgtcagaca     1440

ttacaaaaga tacacctttc tcacaaataa aagagattat tattcaccaa aactataaag     1500

tctcagaagg gaatcatgat atcgccttga taaaactcca ggctcctttg aattacactg     1560

aattccaaaa accaatatgc ctaccttcca aaggtgacac aagcacaatt tataccaact     1620

gttgggtaac cggatggggc ttctcgaagg agaaaggtga aatccaaaat attctacaaa     1680

aggtaaatat tcctttggta acaaatgaag aatgccagaa aagatatcaa gattataaaa     1740

taacccaacg gatggtctgt gctggctata aagaaggggg aaaagatgct tgtaagggag     1800

attcaggtgg tcccttagtt tgcaaacaca atggaatgtg gcgtttggtg ggcatcacca     1860

gctggggtga aggctgtgcc cgcagggagc aacctggtgt ctacaccaaa gtcgctgagt     1920

acatggactg gattttagag aaaacacaga gcagtgatgg aaaagctcag atgcagtcac     1980

cagcatgaga agcagtccag agtctaggca atttttacaa cctgagttca agtcaaattc     2040

tgagcctggg gggtcctcat ctgcaaagca tggagagtgg catcttcttt gcatcctaag     2100

gacgaaaaac acagtgcact cagagctgct gaggacaatg tctggctgaa gcccgctttc     2160

agcacgccgt aaccaggggc tgacaatgcg aggtcgcaac tgagatctcc atgactgtgt     2220

gttgtgaaat aaaatggtga aagatcaaaa aa                                   2252


<210>  2
<211>  37000
<212>  DNA
<213>  Homo sapien

<400>  2
agagcctctg cctagatttc acaggatgtg tggaaacacc tggctgtcca ggcagaagcc       60

tgctgcaggg acccagccct catggagaac ctctattagg gcagtgcaga ggtgaactgt      120

ggggttggag cccacacaca gagaccccac tggagcactg cccagtggag ctgtgaaaag      180

agttccccca tcttccagat gccagaatgg tagatccact gactggaaag ttgcaggcac      240

tcagtgccgg cccatgaagg cagccgtagg ggctgtaccc tgcaaagcca cagggacaga      300

gctgcccaag gccttaacag cccacacctt gcatcagcat gccctgggtg tgagacaggg      360

gctccaagga gattattttg gagctttaaa atttaatgac ttccctgcta ggttttgcat      420

atgcttggga cctgtggccc ctttattttg gccaatttct cccatttgga atgggaacat      480

ttacccaatt cctgtaccca cattgtgttt tggaagtaac taacttgttt tttattttaa      540

aggctcattg agggaaggga cttgccttgt ctcaaatgag actttggact cggacttttg      600

ggttactgtg gaatgagtta agactttggg ggactgttgg aaagacatca ttggttttga      660

aatctgaaaa ggacatgaga tttgggaaag gccaggggaa gaatgatatg gtttggctct      720

gtgtcctcat ccaaatctcg tcttgaattg taatccccac atgggattac atgggagggg      780

cctggtgaga ggtgattgga tcatggaggt ggtttcccct gtgctgtgat ctcatgatag      840

tgagggattt aaaagtgaca gtttcccctg cacatacaca ctctctctct cgtatcacct      900

tgtgaagaag gtgtctgctt cccctctgcc ttccatcgtg attataagtt tcctgaggcc      960

tccccagcca tgggtaactg tgagtcagtt aaacctcttt tgtttataaa ttacccagtc     1020

tcaggtagta tctttacagc agtgtgaaac tggactaata catctgggaa attctttttg     1080

tctccttcct ttctgaagga cagctttgcc tgatattata ttcttggttg ccaggttttg     1140

tactttcaat actttgaata tatcatccca ctctctcttg gcctacatga tttctgctga     1200

gaaatccacc aataatctta tgaagcttcc cttgtatgtg aagaattgct tttctcttgc     1260

ttctttgaaa attctctctt tgtcatggtg aggatttctt tttttttttt ttttttttag     1320

atggagtcta gctctgttgt ccaggctgga gtgcagtgtg cagtggcgca atctcggctc     1380

actgcaagct ccgtctcctg ggttcacacc attttcctgt ctcagcctct ggagtagctg     1440

agactacagg tgcccaccac cacgcctggc taaatttttt ttgtattttt agtagagatg     1500

gggtttcact gtgttagcca ggatggtctc gatctcctga cctcatgatc cacccatctt     1560

ggcctcccaa agtgctggga ttacaggcat gagccactgc acctggccga ggatctcttt     1620

atatttaatc tatttggagt tcttttgggc ttcataaatc tggatgttta tttcatttat     1680

gtctccaaat tttgagagtt ttctattctt atttttttaa ataagtttct gcaactttct     1740

ctttctctac ttcttctgga actcttctaa tgcatattaa ttttcttaac agtgtcctat     1800

aagtcttgtc agctttctgc aatttttatc attcctttta ttactctgac tgggtaattt     1860

caaatgacct gtatctgagc atgctgattc tttctcctgc ttgatctagt ctgctgctga     1920

agctgtttgt gaattttttc aattcagtca ttttgttctt tagctccaga atttctgttt     1980

cattcttttt tatggttcct atctatcttt ttgttgaact tctaattttg ctcatgtatt     2040

gttttcctga ttttgtttac tgtctatcta tattgttttg tagcttattg agctttctta     2100

aggcaattat ttttagctct tgtcatgcag taaagatctc catttcttta gggtcacctc     2160

ctgctgcttt atttccttcc tttggtggtt tcttgtttcc ccgattattt gtgatcagtg     2220

tggccttgca ctgaagtagg cacctatttc agtctttaca tactagcttc agcagagaaa     2280

gccattcact agtcagattg accagagatt gttggtgggc tgtctgttgg ggtctatgca     2340

caggatttct gctggagttc taaggtggga agggctggat tctgggttca ttcactgtgg     2400

ttgtctgtat tctgtgcaca aggactggct tgaagcatgg atccttgggg gctgacttgg     2460

cactgaaatg agccttaagc ctgcgtctgc aggggccagc ctaacatggg gatcacctgg     2520

cacctgagtt catggggata ggcctgttcc tgagtttatt caggctgtcc tgggaacaag     2580

gtccactggg gtgagcccag catctgggtc cacatggccc agcatggagc caagatctct     2640

ggaggctgac ctggtgctgg atctgcaggg gatggcctgg attctaggcc catgggtgcc     2700

aacttggagc ctggggttgc tggggctaac gtggaggcta gatagagtct tgggggccag     2760

gctagagctg gagcaggcct gaagtctagg ttttgtgtgg ccatcttgga gcctgaagcc     2820

ccaggggctg acctggtctg gggtgagcat ggggctgagg ccacagaggc tggtctggcc     2880

tgtggcaggc ctgaatcctg gtgctggggt ttactggagt gggcttggtg cttgggatct     2940

gtggtgaagt taggttctat cttaactgtc cctcctccat gcaagagggc atctctctcc     3000

atactgtgct gcccaggctt gaaggtgaga tgacaccggt aatgtgaaat tgtccttcct     3060

atacacttct atgtgtcttt tcttatttct gtgctgcaac caggtggcat aacctctcac     3120

ctgattcctt agctctagtg aagttatttt cgtgcatgga tacttgttcg aattgatgtt     3180

tctgcaaggg atgagcgcta gaaactcctg ttctgacaaa ctcctattcc tattcttgct     3240

gacatcactc cctgaaatag ttaatatact taacagctga acacggatag gatgttcatg     3300

gaatatgttg acaggacaaa aagttgaaac tgttggcaga aacccaaagt caatattgaa     3360

gccaagcaaa atattgcctg cagtgccaca ttagaacagc ttgaagaccg ttcattttta     3420

agtgacaaga gactcacctc caagaagcaa ttgtgttttc aggtagcaaa tttttattat     3480

tctgattgtt tccaaataaa ctataatttt taagtataat tttttacttt atgagaaaat     3540

taatcattta tattctaatt tcctgagtat gtagagagta tagataatgt tcctttatgt     3600

agaaatattt aaatgtaaga tgattttaaa tcagaaagaa tatttgattg atttaaaatt     3660

tttaaatggg ctttaatatt ttcagaggtt ttctttactt agggattttt ggactgacat     3720

tattgccatt atttattaat tttgtttttg cccaaatcaa gaggtttcat aattgtttac     3780

tctctctcta ccaattccct ttccaacatt actagccaca gagttggcca atgaacaata     3840

aacacaacag tagtctggag gtctcaattt gtatcttggg aagcattata aattttccaa     3900

ctccctagac acaaatgtac caaaaaaaaa cccttgtttt ctataccagt aattgtgtgc     3960

tttgtcttgc aattcagaca tttacaagaa aatctaaatc accttaaatt aagatttatg     4020

ttaaatgtgg tctaaaacca gcagagttat gtattgtttt cttttttaga atgattttat     4080

tcaagcaagc aacttatttc atttccttgt ttgctacagt ttcctgtggt aagtgaatta     4140

tctataaaac atggaattca ggctaagaca ggagtagcca agcaagtggc accacccctg     4200

gagaaagcta ttgaacatac agcttcgggg gtggagattg tccctgatga ttcaggacac     4260

gtgtctattt aatgttccac aacaaggacc acttgtcagg tatattgctg tagacatatg     4320

ttgcagacca gaggaaggag ctcagaagta ggaatgtctt gggacttgtg ttaacaaaaa     4380

cttctgttcg cagatgacac tctgcaaagc aaaacttgaa acaaaaaaaa attagtcctc     4440

tatttttatt atcaacagta aaaaattaaa ctttatctga aaattcaaaa gagtgctagg     4500

cattttatag tgtctgggtc caatccaagt atctgttagg aacaccatac atagttttac     4560

tctggaccgc tagggaacca tttcaaaaat gaaagtaact ggtttaaatt taacttagca     4620

aaccatgcat ttggatagtt ctaggtgaat agctttcaac accagattta gatctcattt     4680

ctctattaat ttcattaatt tttggagaat aaaaatgatt ctggacattt cattaatcat     4740

tacagaggga gttttctctg tgtccccaca aggcatgatt ctgggtctat ggtgacttaa     4800

gagggccaca caacaatgag tatttaattt tcctcagatg tatggctaca ataaacatct     4860

ataggtaagg tttacattca taaagagacc tttttttttc caggaaaaaa gacttttatt     4920

ccccctaaat cacaactccc ctgtgtctgt ccctcaaccc tgatttctct tctaaaccgt     4980

aatttacaaa cccatgtgca aacccactga aaggtgagaa ggagcataag ccagagacac     5040

tgggaaccac agccaactac agggggtttt tcattttttt gttttgtttt gttttttggc     5100

aaaataaatc atgattatgg ctaggaaaat cagggatgta agtaagcaaa aatttagaaa     5160

ctacatattg catgtagtcc ccaaattcag aaacagtcat cgttaaacat cttttattta     5220

gtctttcaga tatttttcta catataccta tttgcacatt tcacaaaaaa gagttattaa     5280

ctgtggacac tctttgactt gcattttcca cttatagcta tcttttggtg caaataagta     5340

atatattttg gagcttgcta ttcttctctt tttatggtat ttttgtgtgc acattcttat     5400

gctcttattc agttatttct gtagaataca atttttgaaa taaaaatact agattcaaag     5460

gtgtgaatat ttttgaaggt tttgtggtgt ggtatcatga aattaggttt cagaaagttt     5520

actccatagt tgactttttc taccagctaa taagagtgct catttacccc acttaggcca     5580

actctaacag gcttctgttg ctttgcatcc tgacatattt atctttctgg aaacagtgtc     5640

ctaatttatt tctgcagagc tactgcctct cagttttggt ccatgtggtt ctggtgaccc     5700

tgattcttct gctgaaccag aaagtgcaca catcctcctg gctgtggtga cccaatcaga     5760

gccaacgtct tgcaatgaag cttttcttta gacatctaga aataagactc ttatgttttt     5820

tttttccaat ttgacttgaa acttaagaca atacacaggc ctgagttgtt ggtactattt     5880

tgctactacg tggagcttga gagtaatggt aacaccaaga ctggagcaag tggaaggaga     5940

catattgtcc actgatgcta tcagttgagc acaatgtgca gttacttttt aagccagatt     6000

caccatgggc tttttggctc ctgaaccaat agatttcatt tgttttcaag ccactttgta     6060

ctaggttttc catcatttgc aatcaaaacc agtatacaaa cactggttat ttaatttttc     6120

atttttgcta atctcaggga taaaatggct tctagttgtt ttaacttggc tatatttgtg     6180

attcttccca ttttcatata cttactaatc acttctattt cttttgtaaa ttatcttttc     6240

atatttgtta tctaattctt taaaatttga gtactttaat tctcattatt gtttgtggaa     6300

ttgttaaaca agactgaata atctgcccaa agtccatgga catgggggcc catgtaaaag     6360

ctttgaaagc caccatcatt atgagataaa ttatataata gtactttaca taggctccaa     6420

aatacagcac agacacagct atcattgtca tggtcatcat tatcatcatg atcaccaact     6480

tatgaggata agcaagaaca cctactagaa gtttctttcc attcagcaac aaaattggtg     6540

tctttctagt cactcccttc cctgactgtc acatagcagt tcacagaggc tcagttgcag     6600

aatgagaagc tctgggccag gacctgccat tgtatgcatc cttgcatggg aactgggggc     6660

tggaagagga gtgactgctt gataattatg agtcagtcaa aaccaccaac tgtctgaaaa     6720

aaataggcct ttttgtaact agtattgtca ctaaaccaac tcctccatgt tttgtgcata     6780

catgaaatct aggcaataca cttgtattcc caaaagcttc cacttgaaga gatctgtgct     6840

ctttccaaat ataaacctta cccgagaggt ggtcatcttg gccacacctc agagagggag     6900

agaggcagtc ttgttgggtt gggtggtcat aatggggctc agggccaaat ccccaggggg     6960

taggatagtg cagagaagat ggcactctcc agtgcttaat aaaatgcacg tggtctaagc     7020

tgcccactcc ctcaaaggca ataaaaaata ggtactattt aaattgaaga gtaactactg     7080

ccccagggaa tggacaggtt gtcattggaa tagccatggt taatggtccc agttgacaac     7140

tgaaatgaat gtgctacctg aacaggaaag cttattaacc agatttcaaa gacagtcttt     7200

cccggtaaat ccaaatttac aaattaaagc cagtaaagac accgaattct ctaataatat     7260

gtggggtgca gtatatttta gagctgggaa taattccaaa cagcaaatag ttcaaaattt     7320

attttcaatt tagcatatgc atgcatttgc ttaaactgtc ttaaaaatga gtaaaaaata     7380

ctgtcagttt gtttcaatca tactgagatg aggaacaatg tttagcattg catgctagaa     7440

aaggacacag gattgggagt cagggctggg tgaccgtcac aggactttca ctaactgtgt     7500

ggatcttggg caagtctgtg tgccctgaga ctcagttatt taactttctt ttaaaaaaca     7560

tagtccagat gcagataaca aagcctgcct ctaatttccc ttacagaatt gtgagaagct     7620

ggtggagatg tttgttacaa aagtgttttg aaaatagagc aaatattatt ctttttaagg     7680

catgatgttt tcatagcatg tcaggcaaca ggaaaaaact aagttaggat tttattttat     7740

tgtggggaat ttatgtgcaa attattgtgc aatttaatga aaataagcca atgttttata     7800

cagaagtacc cagaaaatta aataacacta tacattgttc aaatagttgc cttaatatat     7860

tttattttct cagcataatt agagttgtat tatacaggtc tttgagtagt cagtcagtgg     7920

gagaagttaa gacaacagat atctttttat taaaattatt atatgaatta tcgcaaatta     7980

atttttatgg ttctgtcaca ggatgtctga ctcaactcta tgaaaacgcc ttcttcagag     8040

gtggggatgt agcttccatg tacaccccaa atgcccaata ctgccagatg aggtgcacat     8100

tccacccaag gtgtttgcta ttcagttttc ttccagcaag ttcaatcaat gacatggaga     8160

aaaggtaaaa gttggtattt cattattgga gaagctgttt ttcaaaactg aatcagtttt     8220

gtgcagaaag gtgtagtata actgagagtt cttcctcaca cggggttcaa ggaccagctt     8280

cagcaaaatc ccgtcaagtg gttcttacaa atgcagattc ctaggccaca acccagatct     8340

gctgaaccaa agtttcttgt gaccaggaat ctgcatttta aacaatcact gtgtttcttt     8400

aaagtagtag aagctagtca ttttctattc aaagcctcaa aatgcttgaa tatcattggg     8460

ctaagggatt gtctcaagaa agagtctaac aggtgcacat ttcatctgaa taaagaaaca     8520

gatttaactg tgtgacccat gatcacatta gcggatagca cagtccaaag aaaataacat     8580

aagacaagca ttttgctgag aatgtaattg agaaagatct agaacttgtg attttgggac     8640

agggcagttc taaatggggc ctatagtgag ccagtttggg cacctgtggc atgatgctat     8700

gtatggtgtg tgtgtgtatg tgtgcttgtg cttgtgtgaa tatgtattat taactggaaa     8760

tttgtaaaag tattggaaaa atagtactta cgattttgtg tgtgtgtgtg atggagtctc     8820

gctttgtagc ccaggctgga gtgcagtggc gtgatctcgg ctcactgcaa cttccacctc     8880

ccaggttcaa gcgattctcc tgcctcagcc tcccaagtag ctgggattac aggcacgcac     8940

caccacgtcc agctaatttt tgtagtttta gtagagacgg ggtttcacca cattggccag     9000

gctggccttg aactcctgac ctcgtgatcc acctgcctct acctcctaat gtgctgggat     9060

tacaggcatg agccaccgca cccagcggta attacaattt ttattaggtc agagagatgc     9120

ttattaatca cgagccacag tttcatctta atgatttttc cttttgatta atatccagag     9180

taagcttttc tttgttgttc ccatttccat gttcataact ctttactcat cttcactcta     9240

tgtgagttta ccaactagaa attggatagt cattctctga tcccacatgt taaacttgta     9300

gagaaaactc agattgtatg tgaggatcat catattaaaa gtggaggaag gttctagaat     9360

tcttataaat aatgaaatta acatgaaggt ggacatctaa gacagaggga agtcttccat     9420

taagtgcaga ctacaaggag ttaataagca agatgaacac gatatacaaa tccagctctt     9480

atcactaagt taacttttta agtaaatgaa agtatttgca aaaataatta ccaattgaga     9540

acatagttgc ctgaaagttt aagaacacag gaaaaatcat taactcttta atatggttga     9600

tttcctgtac ttaaaaaatg tgagtgtaaa gaaaacgcag tgatggagtt agatattatg     9660

gggtgttata aaattagctc taagagtgtt ctttccagca agtattgggg aagctatatt     9720

attttcctta ttcctggttt tatttgttag tgtgtagaaa atgctagaca tttcctcaat     9780

gtatgtttat tattctactt cctaagtaaa gctactttta aaataggttt ggttgcttct     9840

tgaaagatag tgttacagga accctgccaa aagtacatcg aacaggtgca gtttctggac     9900

attccttgaa gcaatgtggt catcaaataa gtggtaagtt gtgaatttct tagctacatt     9960

tgagttaata ttggatctcg cttagaacag cttttgctca aagtttgtac tgctacagct    10020

ttttggaagg catcactcat aaagatagga gatggggcag tattctggac acaaaagagg    10080

gacccatatt catctggaca cttctattgt ctttataaat caacacatac ttaatgagcc    10140

tctattattt atgaggttag cgctcaagtg taagatttgc agaaaatgaa tccaaataat    10200

tgtgtctcgt ttccagataa gaatttttaa gaaaacacaa gggaacatct ctctcaagtt    10260

cacttgaggg taatttttac atcagtgatt ctcaaccagc agtgattttg tctcttccac    10320

tggggacatt tgacaatgtc tggagacatt tttggtggct acaactaggg aggatgctat    10380

tagcatttac taagtagagg ccagaatgtt tgaatgctga ccaacattct acaaggcaca    10440

gggcagtcgt ccacagcaaa taattttctg gcccaaaacg tcaacagtgc tgacatcaag    10500

aaactctgtg atataccact aggcccaaat tgaagaactg agttctgcaa atcttgctaa    10560

gaataatact tcctaaagga aacttgagga ctaggatgct agagaacttt gattctgaca    10620

tctgaagcta ctgatgtctt gggaaacagt ttccaatgct atcctaataa atttaagaca    10680

aatgaactat ttctcaaaca tgactgggac tgataagaaa gtgaaaagtg ctgaaaagat    10740

tcaactgatg ggttgtcaga atcttaaaat aactgctgtt attctatgta tgactatata    10800

tcattactat tttattttca ttatgcacaa ttaattttgt aggttcaaat ttcagatgtt    10860

tttaaatttg tcatcctttc ctccctcatt gatatcacct cttcaatacg tacacacttt    10920

gagcctgctg tttgcatttt aaccagttat caaaggatgg caatgccttc attataaatg    10980

tgggcctgac ttagccagta taataggtgt agtctacgtg aggtggagta catttcctat    11040

tttaaaagat caatttttat gttaatccaa tttggtataa attattcgag taagtgctat    11100

ttctgattgt tgtatcttgt agcaaaattt aaagaaaaag taatttgtgc ctttctcaat    11160

attcctgtta ttgttcatgt attctaaaac tcactgttac tcacttagct tgcttttaat    11220

gttttttaaa gtgaaaaatt gttcccaagt acataaaatc tctacactca agaacaattc    11280

tagtcaaaag catttagagc ttccgtatga acacttaaag agtttttatt tgtaagagtc    11340

gcatcccaac tcttagcctg ttcttttctc acatgcagaa aaataggaaa gagacttcgt    11400

ttccacagtc tgcaaattcc tgtgtttaag aaccacagtg aataatccac ctccctgccc    11460

aactcatcgt actgtcatat agttttcctg acagtttgtg tattttctgt ctttcccacc    11520

cttaaattta gttttatgac ttcaaccata cttcttagga gtggaaaggt atctgtagta    11580

gattatggtt tattccacat aatcttgggg aataaaactt taaaaaagta tacagtttat    11640

acttctggtt acattacttc cttaaccaaa agtctaacca agaaatttga atctttaaaa    11700

aaaaaagagg ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg gaggccgaga    11760

cgggcggatc acgaggtcag gagatcgaga ccatcctggc tgacacggtg aaaccccgtc    11820

tctactaaaa atacaaaaat tagccgggcg tggtggcgcg cgcctgtagt cccagctact    11880

cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagtcgag    11940

atcgcgccac tgcgctccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa    12000

aaaaaaaaga gcctaatttt gcttcactgt ctgtgaaaag aattatctgt atcttttgca    12060

tgtaagacaa atctcaatga aaagggtgct taaatagaag ttaacactat tttaaagcaa    12120

gaatggaagt ggtttcatca tgcgtaaaca acaactctcc acattttgta atgattgatc    12180

tggatgcaat ttgtcatcag acaggagaag tcgaaagcaa agaaataaca ctgggagata    12240

gagaagctct ttcattcaat gcgaaaggtc aaaggcacat cagtttcttt aataatgcaa    12300

acctcagcac acattatcag tgtcctcatt attattgcct tgtttatttc ccactgctca    12360

ttgataattt caacgtgaaa tttacctgta ttgctgcatg catcttgcag tttaagaagt    12420

gaagtaaccc aatttcaaag ctagtgcttt agggaaaata ttggattgta tttacttcaa    12480

gcagagttcg ataatttatg tacataataa aaattttaaa tcccttagtt aatatagcag    12540

ttgccaaaac tgggctatta tcattctaaa ctaccaaccc aaatggtagt gggtatctaa    12600

tctacctcta gaaagaaaat ggactgtatt tgctctatgt atttttcttg tacagcttgc    12660

catcgagaca tttataaagg agttgatatg agaggagtca attttaatgt gtctaaggtt    12720

agcagtgttg aagaatgcca aaaaaggtgc accagtaaca ttcgctgcca gtttttttca    12780

tatgccacgc aaacatttca caaggcagag taccggtgag tacaattcaa ggtgtgtgtt    12840

ctttgtattg gtgcctccag gatttcactg tattcttctt aacctctttt gttcccaaac    12900

taaaaaccaa acagggcttt tattctaacc actttcctca tttacttact ctattttatt    12960

tttttatctt ttatttattt atttatttat tgagatggag tcgcgctctg tcgcccaggc    13020

tagagtgcag tggcgtaatc tcgactcact acaacctccg cttcccgggt tcaagcgatt    13080

ctcctgcctc agcctcccga gtagctggga ttacaggcgt ccgccaccat gcctggctaa    13140

tttttgtatt tttagtagag tcggggtttt actatgttgg tcaggctggt ctcgaactcc    13200

tgatcttgtg atccacccac ctcagcctcc caaagcgctg ggattacagg catgagccac    13260

tgcgcctcgc ccttcatttt ttaattaaat aattcattta atttcatttg tttctctact    13320

cttttcccct ggcatgtaat tgtaccgcat cttcaaagcc tgacatcctc ttcccctact    13380

tctccaaagc tgattcttgc aggtctttcc tcaaataccg tcccctccaa aagcccattt    13440

ctgagcattc tcttttaagt cacactcagc tctgtttatt tcattcatag agctaatcac    13500

aatttgatat taacttgtga tttttttcct tatttttaaa tcttattttt atttgcatag    13560

atgtatgggg tacaagtgta attttgttac tttgatgtat tttacagtgg taaagtctgg    13620

gcttttggta tatccatcac tggagtcatg tacattgtac ccactaagct atttttcaac    13680

gcccgccccc ttcccacctc tctgtcacct tcccagtctc tactgtctat cgctccatgc    13740

tctactcaat tttggtgtca ttttttcctg aagcaaaatt ttggtgtcat tttttctgaa    13800

gtcattttct gaagtctgtg tcatttttcg ctttcctgaa gcgaattttg gtgtcatttt    13860

tcctgaagtt ccgtttgccc cacacatagg ccttgcttat agaatgaggg tttagtgtca    13920

cggagtctcc tgcctcattc tcaccctaac ttttccttta cccctttgcg aggggaagga    13980

tgtccattag gttaataatg cagaccccta acccactcat tatcagggtc attgtttttc    14040

cactgtgcat tttaatacta actgttacct gcactgctcc ctgcccctca aagtgcagaa    14100

agcaaagtaa cctcttttct tcccattcag gaacaattgc ctattaaagt acagtcccgg    14160

aggaacacct accgctataa aggtgctgag taacgtggaa tctggattct cactgaagcc    14220

ctgtgccctt tcagaaattg gtaattgtag gactacttca ctttgtgatt gtggtaggtg    14280

gaataggagc ccccagagac gtccctgtgc tgagccctgg gacctgtgcg tgtgttccca    14340

tagctggcaa aagcgtttct gtcaatggca tgcagttacg ggcttcgaga tggggagttt    14400

actctggatt ttctgaatgg gcccaatgta ctcacagggt tgagtgctca caaggctcat    14460

aagaaaaaga gagaggcgga aggctcagag ccagagagag aggtttgaag gtattacact    14520

gctggctttg aagatgaagg tccgtgagcc aaggaatgca ggcggcctct agaagttgaa    14580

aagggcgagg aaagagtttc cctgtggagc gtcctggagg aagaagccct gctgatgtct    14640

tgattttagc ccagtaagac ccaatctcta gaacagtaag ataattaatt tgtgttgttt    14700

ttaaccacta agtttgtggt tatgccccta gagcagcagt tataggaaac tagtacagtg    14760

atactgttag agttatagga cagtgatata ggacagtgat actgttatag ttataggaaa    14820

ctagtacagt gatactgtta gagttatagg acagtgatat aggacagtga tattgttata    14880

gttataggaa actagtacag tgatactgtt agagttatag gtacagtgat attgttatag    14940

ttataggaaa ctagtacagt gatactgtta caggtacagt gatataggac agtgatactg    15000

ttataggaaa ctagtacagt gatactgtta gagttatagg tacagtgaca taggacagtg    15060

atactgttat agttatagga aactagtaca gtgatactgt tagagttata ggtagagtga    15120

tataggacag tgatactgtt atagttatag aaaactagta cagtgatact gttatagtta    15180

taggacagtg atataggaca gtgatattgt tatagttata ggaaactagt acagtgatac    15240

tgttagagtt ataggtacag tgatatagga cagtgatatt gttatagtta taggaaacta    15300

gtacagtgat actgttagag ttataggtac agtgatattg ttatagttat aggaaactag    15360

tacagtgata ctgttatagg tacagtgata taggacagtg atactgttat aggaaactag    15420

tacagtgata ctgttagagt tataggtaca gtgacatagg acagtgatac tgttatagtt    15480

ataggaaact agtacagtga tactgttaga gttataggta cagtgatata ggacagtgat    15540

actgttatag ttataggaaa ctagtacagt gatactgtta tagttatagg acagtgatat    15600

tgttatagtt ataggaaact agtacagtga tactgttaga gttataggta cagtgatata    15660

ggacagtgat attgttatag ttataggaaa ctagtacagt gatactgtta tagttatagg    15720

acagtgatat aggacagtga tattgttata gttataggaa actagtacgg tgatactgtt    15780

atagttatag gtacagtgat attgttatag ttataggaaa ctagtacagt gatactgtta    15840

gagttatagg tacagtgata taggacagtg atattgttat agttatagga aactagtaca    15900

gtgatactgt tatagttgta ggacagtgat attgttatag ttataggaaa ctagtacagt    15960

gatactgtta gagttatagg tacagtgata taggacagtg atactgttat agttatagga    16020

cagtgatatt cttatagtta ccgtggtata gttatagtta aaggtacagt gatattgtta    16080

tagttatagg acagtgatat tgttatagtt ataggacagt gatgtagtta cagtgatata    16140

ggtacagtga tattgttata gttataggac agtgatatag ttataggaca gtgatattgt    16200

tacagttata ggtacagtga cgttgtaata gttataggac agtgatattg ttatagttat    16260

aggtacagtg atgttgtagc aaaactgtaa ggtcattcct tggttgtgtc cctatctagt    16320

gaaatgactc taccaggggt agggaaataa aactctgtcg tttcacacat aaaggtaatt    16380

tcaatggaat tatccagaaa attgccatga cattccacct catttagcat gtcaggatgt    16440

taatgacaag atgttactaa aagcaaatcc cttacggcca gttttccgca gtactgggtg    16500

ctggctctgt gcctggccct gtattgggtg ctgggctagg atttccctgt ggaagattgg    16560

gaaggttggt tacaaggtgg ctattttcct gtctcctctt tgcgacagca caccttctcc    16620

atggtgtgtg ccaggttcac gtgtactggt gatttaattt taacgttcat attatttttt    16680

tctgggagag tttttgaagg ctgccaggag gcaggactcg atgcaaacat gctccattct    16740

gtacccagcc ctgttgctgg aaggatttgc tgcacttacc cagggaacag gcaagctcgt    16800

gctgtggctc tgggctgtca cagctgctgt ccacacctgg gagagcaccc tggatggctc    16860

atctgtgtac ttgctttctt gttaaattgc agtgagttca catgtgattt aatcggatca    16920

aatggccttt acagactgat aaaaatatgg ctgtttcagg tggtgttttg agctgctaag    16980

ggcgtggctt ttcactgagt acgtggtccc cgttcctcag ggaacaccca gtagccacat    17040

gcctcctaaa cctagagtag ggctgtctcc tggcctaact gcccaaatga gattcataag    17100

ttagggatga tctgtagtta tcactacaga tttgtccttg gtttcaccaa ggattttcct    17160

aattttacaa acaaaacccc taaggctcct ggaaggaggg tagaagtgaa ggtgctccgg    17220

gggcaacaca gctgatgagc tgaaccagaa ctcgaccctt gggtcacaca catttcacag    17280

tgctcactcc accttttgtt tttttaatgg atttaatggt gttttaaagc ctcctgcctc    17340

tcaacacata tgaattcatt atatttacag atttccttct cttgtggtcc atcttcctgc    17400

atagatcttg agagatgtca ggctaaccac gtttcctcag ttaatttaac aaaaccattt    17460

gcaactctga catggaaaat tcctaccatg tgacttatta atttatcaat tgagatggta    17520

cacatatttt caagccaaaa ggaggaaaac ataaattgga aaaaaaaggt ttttttattt    17580

ttatcacctc tggggaagaa agtctgataa acgaagctgg ttgataaaat tgcaattagg    17640

ggaagcaaca tcatggtttc tgttcggagg ctaaccagat ggcatacttg aaatagagaa    17700

tgtcctagaa atcaactggt tgcttggcca aaatatctat aaatagtgcc caacatatta    17760

gataggaaaa gcaaagtaaa aacaatttta acaggttagg acattgggct gaagtattgc    17820

atatatttaa tgtcatgtgc gtccgtgtga agagaccact aaacaggctt tgtgtgagca    17880

agaaagcttt ttaatcacct gggtgcaggc aggctgagtc cgaaaagaga gtcagtgaag    17940

ggagatgggg tggggacgtt ttataggatt tgggtaggta gtggaaaatt acagtcaaag    18000

ggggttgttc tctggcgggc agcggtgggg ggtcacaagg tgctcagtgg gggagcttct    18060

gagccaggag aaggaatttc acaaggtaac gtcatcagtt aaggcaggaa ccggccattt    18120

tcacttcttt tgtctttctt cagttacttc aggtcatcta gatgtatacg tgcaggcctg    18180

ggcccagagg cctgacattc ctgtcttctt atattaataa gaaaaagaaa acgaaatagt    18240

ggtaaagtgt tggggtggcg aaagtttttg ggggtggtat ggagagataa tgggcgatgt    18300

ttctcagggc tgcttcgagc gggattaggg gcggcgtggg aacctacagt gggagagatg    18360

aagctgaagg aatattttat ggtaaggggt gatattgtgg ggttgttaga agcagcattt    18420

gtcatataga atgattggtg atggcctgga tatggttttg tgtgaaatga gaaactaaat    18480

ggaagacaca aggtctgaat aagagaagga gaaaaacagg tgttaaagga ctaagaattg    18540

ggaggaccca ggacatctaa ttagagagtg cctaaggggg ttcagtgtaa ttacttgctt    18600

ggttggtgag tttttgggct ctatccttga cagagtcctc ctttttaagt tggaggctga    18660

gcttggtgag gtgtgttttt aaaagaccat tagtctgttc tacctttcct gaagattgag    18720

gatggtgagg ggtatgaagg ttttactgaa taccaagagc ctgagaaact gcttgggtga    18780

tttgactaat aaaggccggt ctgttatcgg attgtataga gatggaaagg ccaaactgag    18840

gaattatgtc tgacagaagg gaagaaatga ccacggtggc cttctcagac cctgtgggaa    18900

aggcctctac ccatccagtg aaagtgtcta cccagaccaa gaggtatttt agtttcctga    18960

ctccgggtat gtgagtaaag tcaatctgcc agtcctgggc gggggcaaat ccccgagctt    19020

gatgtgtagg gaagggaggg ggcctgagca atccctgagg aggagtggag tagcagatgg    19080

aacactgagc agttattttt tgaggataga tttttacgac ggaaaggaaa agtgaggttt    19140

taagaggtgg gttagtggct tgtaacttac atggaagagt ttatgaaatg atgacagaat    19200

agaatgggcc tgtgaggctg gaggagatat tttccttggt ccaagaatta tttgccttgt    19260

gtgggaagag attgataggt ggaagtttca atgggggagt agatgggagt gacagatgag    19320

gaagaaaaaa actggctgtg agggatagaa gttggaatgc tcgctgcttt tttagctacc    19380

ttatcagcat aggcattgtc ctgagcagtg ggatctgatg ccttttggtg gcccttgcag    19440

tgaatggctt cagcttcctt tggaagtaaa gtggccttga gaggagtttt tattaaagag    19500

gcattaagat ggagaaccct tgtgtagtga ggaaacctcc ttcagcccat ataaccgcat    19560

ggtggtgcag aatatggaag gcatatttag agtcagtata aatattgaca cgtagtccct    19620

ttgcaagagt gagggcctga gttaaggcaa tgagttcagc ttgctgagag gtagtggagc    19680

ggggcagagc agtagcctca gtgatagatg tggaagatac tacagcatag cctgcctttg    19740

ctggtgagtg gtgattaggc ctggtggaac tgccatcaat aaaccaagtg tgatcagggt    19800

aaggaacagg aaagaaggaa atatggggaa atggagtgga tgtcaggtgg atcagagaga    19860

tacagtcatg ggggtggggg ccagcctaaa acagtaaggt caagttgttt gaacagaaag    19920

gctacagggc gtggtcctgg ctcttgtgta agaattttga ctgcgcagcc ctgcacttcg    19980

gctgtgtgta atgaaaaggg ttgggatgag ttagggagag ctagtgtggg agcagtttct    20040

agggctgttt ttaaggaatg gcaagaggag tggctaaagg atttaggatc tttggggtca    20100

gctagctttg cttttgtgag tttatataat ggtttagtca ggatggtaaa acttagtatc    20160

caaaggcgga agtacttaac catacctagg aagaaaagga gttgttttgt agaaggggtt    20220

ggggtttggg agatgagcca gacacaatca gcagggagag cacatgtgtt ttcatgaaga    20280

attatgccga gataggtaat ggatgaggaa gaaatttggg cttgactgaa gtaatggggg    20340

ctgtcctcga agccttgtgg cagtacagcc caagtaagtt gctgaggctg acgggtgtca    20400

gggtcagtcc aagtgaaagc gaagagaggc tgggatgaag ggtgcaaagg aatagtaaag    20460

aaagcatgtt tgagatccag aacagaataa tgggttgtgg agggaggtat tgaggatagg    20520

agagtatatg gctttggtac catggggtga ataggcaaga caatttggtt aatgaggcac    20580

agatcctgaa ctaacctgta aggcttgtcc ggtttttgga caggtaaaat gggggaattg    20640

taaggagagt ttataggctt caaaaggcca cgctgtaaca ggtgagtgat aacaggcttt    20700

aatcctttta aagcatgctg tgggatggga tattggcatt gagcggggta agtgtgatta    20760

ggttttaatg ggatggtaag gggtgcacga taggttgcca aggagggagc agaggtgtcc    20820

tatacttgtg gattaaggtg gggacacaca aggggaggat gtgaaggagg ctttgaactg    20880

gggaaagggt ggcattgagg tgtggctgtg gcctaagaac agtcagggaa gcggataatt    20940

gagttaaaat gcctcgacct agtaagggag ctgggcaggt ggtgataact aaaaaggagt    21000

gcataaaaga atgttgtcca agttggcacc agagttgggg agttttaaga ggtttagaag    21060

cctggcggtc aatacctaca acagttatgg aggcaaggga aacaggccct tgaaaagaac    21120

gtaatgtgga gtgggtagcc tctgtattaa ttaagaaggg gatggattta ccctccactg    21180

taagagttac ctaaagcatc tgtgatggtc caggaggctt ctaaggtgat cgggcagcgt    21240

cagtcttcag ccgctaagcc aagaagatct gggaagcagt cagtcagaga gccttgggcc    21300

agagttccag gggctctggg agtggcagcc aggccagtta gacagtccga tttctagtgg    21360

ggtcccacac agatgagaca cagcttagga ggaatcccag gctgcgggca ttccttggcc    21420

cattggccag atttctggca cttgaaacaa gatcctgatg gaggaggtcc tgtaggaatg    21480

cttgaccact gcagtttagg cattttgaag tttttgtgtg tgctggagat gtggctgggt    21540

tttgtctcac agcagaggca aggaatcgca actcagaaat acattgctac ttggctgcct    21600

ctattattgt acatcttgaa ggcgaggtta attaagtcct cttgtggggt ttgagggctg    21660

gaatctaatt tttggagttt ttttttgttt gttttttggt tttttttttt taatgtcagg    21720

agctgactgg gtgataaaat gcatattgag aataagaggc cttctgaccc ttctgggtct    21780

agggctgtaa agcgtctcag ggttgctgcc aaacgggcca tgaactgggc tgggtttttc    21840

atatttgatg aaaaagagcc taaacgctaa ctgatttggg agaggtcgga taaataaaaa    21900

ggaacattaa tcttgactat gcctttagct ccaaccacct ctttaagagg aaattgttgg    21960

gcaggtgggg gagggctagt cgtggaatga aactgtaagc tggaccgggt gtgaggaggg    22020

gaggtgatag aaggattata gggtggagga gcagaggctg aggaagaatt gggatctggc    22080

ttggcctggc aaggagcagc ctggggagga ggggagaggt cagatgggtc catagaaaag    22140

gaggattgga aagactcagc aacacttggg gttgggattg agaggacaga tgggttggga    22200

ttgaggggac agatgggagg gaaagaagga agatttggga caagttgcat tgggaacaga    22260

gactagggag ggaccaatgt gtaaaagaat gcctggacgt caggcacctc agaccgtttg    22320

cccattttat gacaagaatt atctagatct tgtaggatgg aaaaatcgaa agtgccgttt    22380

tctggctatt tggaaccatt gtcgagtttg tattggggtt aagcagcatt gcagaagaaa    22440

ataaggcatt taggttttag gtcaggtgtg agttgaagag gttttaagtt cttgagaaca    22500

taggctaagg gagaagaagg aggaatggag ggtggaaagt tgcctatagt gaaggaggca    22560

agcccagaga aaagagaggg tagagacatg gagagaaggg gtgggggggt gcttgccccc    22620

aggaaagtgg ttcttgccac taagggtgaa ggatcaaggc aggcattcgc gcggtgatca    22680

gatacctctg aaacgtgggt gaataatcaa gcaggtgtcc ctgcagtgat taaacagcaa    22740

ggaaagacta tcttcccaag tccatgacca gtgccagagt tttgggttca tggataaaac    22800

gcgtctcctc tgtctctacc agaaaatgaa aggaattgaa attaagagaa gggagagatt    22860

gaaggatggc gccaagattg aaaggaaaaa gaggttgagg gatagggaga gaggttggat    22920

aagagagtaa aaagaggctg cttacccaat ttaaaatcgg tgagatgttc cttgggcttg    22980

ttggtctgag gaccagaggt catgggtgga tctttctcat ggagcaaaga gcagggggac    23040

aggggattga tttcccaagg gaggtcccct gatctgagtc acagcaccaa atatcacgtg    23100

tgtccatgcg aagagaccac caaacaggct ttgtgtgagc aagaaagctt tttaatcacc    23160

tgggtgcagg cgggctgagt ccaaaaagag agtcagtgaa gggagatagg ggtggggacg    23220

ttttatagga tttgggtagg tagtggaaaa ttacagtcaa agggggttgt tctctggcgg    23280

gcaggggtgg ggggtcacaa ggtgctcagt gggggagctt ctgagccagg agaaggaatt    23340

tcacaaggta acgtcatcag ttaaggcagg aaccggccat tttcacttct tttgtcattc    23400

ttcagttact tcaggccatc tggatgtatg catgtaggct tgggcccaga ggcctgacat    23460

ttaacatgga taaatgtaaa gttcttagaa tcatacatac actttggaaa agatggggct    23520

taatcgcact ttataagact tgaaggatgt ttgagaatca ctatgaaact gctgaaaata    23580

ccaagaaaat ttaattctta tgtatataaa taatgtgtct gttttacatg aatcccttct    23640

acaagcttgg tatttaatat ggcatatatt gttttttcat agtagattta aaatttttga    23700

tatctaattt agataacata aaattaaccc tttgaaagtg tacaactccg tggtttttag    23760

tatatccacc tgattgcaca acgatcacca ctgtctagtt ccagaacatt tttatcacca    23820

caaaagaaag gctgtatcca ggccgggcac ggtggctcac gcctgtaatc ccagcacttt    23880

gggaggccga ggcgggcgga tcacggggtc aggagattga aaccatcctg ggtaacacgg    23940

tgaagcccta tctgtactaa agatacaaaa aaattagctg ggcatgatgg cagatgcctg    24000

tagtcccagc tactcaggag gctgaggcag gagaatggcc tgaacccagg aagcggagct    24060

tgcagtgagc caagattgcg ccactgcact ccagcctggg cgacagagca agactccatc    24120

tcacaaaaaa ataataaaaa taaaataaaa aaaaaaaaga aaggctgtct ttctcctttc    24180

ccattggccg tctttctcca ttccctactc ctccaatccc ctggcaacca ctaaatctac    24240

tttccatgtc tgtggacttg actcttcggg acattttaca taaatggaat catgcaatgc    24300

agcacatttt gcatctggct tttttcacct ggcgtgtttt caaggctcat tcgtattcta    24360

gcatatatca atactttgtt cctatttagg actaaataag attctattgt atgaataaaa    24420

catattttgt ttatatactt agtttgatga acatttgagt tgtttctgga tttttttttt    24480

tttttttttg cctcttatga ataatgctgc tatggacaac agtttttggg taggcatgca    24540

ttttaaattc tcttatgtat atacttagga ttaaaattgc tggatcacag agtaactcca    24600

tgtttaactt tttgatgaat tgccaaactg tttttgagag cagctacaca atgttacatt    24660

cttaccagca acaattgagg gcttcagtct ctctacaacc ttaacaacac ttgttattgt    24720

ctttgtaatt attgcctttc taggcagtgt gaagtggtgt ctcactgtgg ttttgatatg    24780

catttcccta atgactaaca atgttgtgta tcttttcgtg tgctcatttt caatttgaat    24840

acattctttg ggaaaatctc tgtttaaatc ttttggccat taaaaataat tgggttattt    24900

tcattgttga gttgtatgaa ctctttatat actctggata ctacactctt atgacatata    24960

ttattttcaa aaattttctg tgcatctgca ggtcatcttt tcactttact gatggtgttc    25020

tttgaagcac caaagttttt aaacttgatg aaatccagtc tggctttatt cttgcacgtg    25080

ctttacctaa aacgccaaaa cctaattcat ggttttgaag atttttgctt atgatttgtt    25140

cttagaggtt tatagtttta gctcttacat ttaggcattt gatgcatttt aaattaaatt    25200

ttgtatatgg tgtaaagtag caatccaact taattcttgc atgtgggtat tcagttattc    25260

cattgtcttg aaaccctttt caaaatcaat tgtctataaa tgtaagagtt tatttttgga    25320

ccatcagttc tatcctgttg acctatatat gcctatccta atgccagtta cacacagtct    25380

tgattaccat aactttgcag taagttttga actcagacag tctgagtgct tttattttgt    25440

cctttttcaa gattaatttg gttattccgg atcttttgca tttccatatg aattttagga    25500

tggttgtcaa tttctgcaat agaaaagcag caggattttg atagagagtg cattgaatct    25560

gtagaccaat gagtatcaat ggaattatgt gttatcaaat ttagtaaact acataaacga    25620

tatgtacaca actaaaacaa aactaagata taagatcata ttaatgtaat gataataaaa    25680

gtggattgtc tcctgttcta attttaatag gcacaaggca tttttgttaa tcacttctta    25740

ttaaagaatt ttttataata ttcaggaaaa tacaacaaaa aaacccttac attcctaagg    25800

cctcagagtc agagtaatat aaaggaaatg taaacacatg ctgagtaatg caagcatttg    25860

gcaatggtgg tgactggagc tgggagcaca gcttttattt ctctgaaata ggaatttgcc    25920

ccttagagtt agaccaattt tgccttcctc taaatggcaa acagtttgga gatactttaa    25980

aggacatttt ttcacttagg atgtttagta ctatgaataa taaatagtca caatttcctt    26040

aactatggtg acaaaataca agcaaattta gcctcatgtc atttcctaag gaacatcttc    26100

tctctgtgag ttcacaggtt gccacatgaa catcttccag catcttgcgt tctcagatgt    26160

ggatgttgcc agggttctca ctccagatgc ttttgtgtgt cggaccatct gcacctatca    26220

ccccaactgc ctcttcttta cattctatac aaatgtatgg aaaatcgagt cacaaaggcg    26280

agtatgcatg gaaaatcgca tcacaaaggc gagtatgcat ggggagcact tgctgctgta    26340

ctttcatcac ttttatagtc tgagttctta aaagtttcgt tcatttccct caaaacactt    26400

gaacctgcag tttcagtagg tactgttctg ccaggtgcag attagttaag agattagcag    26460

acttctctgc ctatcttctc ttactttaaa acaaatgtta ccattgaatc aaggaagcaa    26520

tagccatgag aaaaaagaag gatctgacgc ctttgaatga agattcaaaa catgatcttc    26580

atgttttgta ttagcttgga gtaaaatcca cttgctggca atatagccct taagcttgtt    26640

gcctcttctc tttgtttcag aaactagagc cctgtttatt ctgatcaagg ctctggccca    26700

ctgtctttat ctcagataac ccaccctctt ctgcacacag catggagcta agagaagggt    26760

gtctagttat gtaatatcat cggcagcata aattcccaga atttgttctt tgattttttt    26820

gtttgttttt ccagttagaa ggtggaactt catcattgtc ctcttttcag gttgtctgtg    26880

cctattagtt ttctccagag ggagaggtgg cttgatttac atttaatctc tgcaatttat    26940

tagagtcctg tagttggatt tactttgaag agagtttccc agaagaataa aatttgctgc    27000

gttgcttttt gggtgtgagc tgcttttgta tttgcctaat gcctttaatg caaatttctt    27060

tctttctctc ttgctttttt ttaaaaaaaa tagaaatgtt tgtcttctta aaacatctga    27120

aagtggcaca ccaagttcct ctactcctca agaaaacacc atatctggat atagcctttt    27180

aacctgcaaa agaactttac ctggtaatgt gatttgataa taatattaca taaaatgtaa    27240

cctatttcat gacttttaac agcaacagtg atgaaacaat cctcaaggta acagaaactt    27300

gtgtaaatgt cgttcattgc ttttcccatc tgatatcttt ttgtgtttat aattgacaca    27360

gaaccctgcc attctaaaat ttacccggga gttgactttg gaggagaaga attgaatgtg    27420

acttttgtta aaggagtgaa tgtttgccaa gagacttgca caaagatgat tcgctgtcag    27480

tttttcactt attctttact cccagaagac tgtaaggaag agaagtaaag gaaattttat    27540

ttttcaaaga cagttgacat gaccatttca tattctcttt ccccctgtga aggcttactc    27600

tttctactgt tcatttcatc taggtgtaag tgtttcttaa gattatctat ggatggttct    27660

ccaactagga ttgcgtatgg gacacaaggg agctctggtt actctttgag attgtgtaac    27720

actggggaca actctggtga gtaacctcac tttttcgtgg acctgtcagg gatgtctgtc    27780

atgttgatag tttgcttagt cttaaggaat tatgtgtctt gttctccttg gttagaaggg    27840

actttgattc acttctaatt ccaaccatta gcgtcaacgc tctcttttca gtctgcacaa    27900

caaaaacaag cacacgcatt gttggaggaa caaactcttc ttggggagag tggccctggc    27960

aggtgagcct gcaggtgaag ctgacagctc agaggcacct gtgtggaggg tcactcatag    28020

gacaccagtg ggtcctcact gctgcccact gctttgatgg gtaagtgttg gatgcatctc    28080

atccagagtc ttatcttggc ttttcatttt gaaggatcta tgatcagctg cttcaccgcc    28140

atgtgacttt atgaatagag acgtgttaaa gcggggatgg tattcacaac atttaactta    28200

tagggtccaa gcactgacca acctgaccat tagaacagag tgtggtctct gtacagggca    28260

gatggcgctg agtgggtatt ctccacagaa agagaaacga agacagtacc ccactcctcc    28320

aacccaccac ccaccaccaa tcccaccacc aattccacca ccaatcctgc cacccaccac    28380

caatctcacc accaatccca ccaccaatcc taccacccac catcaatctc agcaccaatc    28440

ccaccaccaa tcccaccacc aatcccacca cctaccccac caccaatccc gccacccacg    28500

accaatccca ccaccgatcc cgccaccaat cccaccacca atcccaccac ctaccccacc    28560

accaatcccg ccacccacga ccaatcccac caccgatccc gccaccaacc accaatccca    28620

ccaccaatcc caccaccaat ccctgatgtg ttcttcaaag acttatttgt caggcccata    28680

gaaatgttac ttcttgctct ttgattcata aatatactaa gtcataataa tttttaaaag    28740

tgagagtttc gtactctgta tatttcaatg tatataattt gatctatttc aatttattgg    28800

tcaaatagta gacatgttag gtaagtctta aaatactgag gctttggagt tagacagaac    28860

atggcttaag tgacagcttt gctgcttatt agaggtgtgg ccctagaaga tttgtaaatc    28920

cctctgagct ttatttgatc taaaatatga atagtaatag tcccgaattt gtaacgttgt    28980

tgggaagatt aagtgacaca tttaaaatgc ttagtactgt gtgtagaaca taaacacttc    29040

aaaaaatgta aactgtgatt tctatattca ataagaaatg tagaaatgga caaagcatat    29100

aaaaagcaaa agaaatacta gaagacactt gatttttctc aaaaataaac acaccaagta    29160

tttttgtttt agtgaaattc atgcttacat gctgtatact aggattgaac atactgccac    29220

caaaatatag cagtcggtgg tacatgtggg tggagcaaga cccctccacc ttgtcatcgt    29280

gtgaaggggc tctgccatac atgaccttgc atgtgacttt aaggtggttg gcctggaaga    29340

aaagtcccaa gatgggaaat agtaggtgtc ttttttacta aatgcactcc aatttgggac    29400

caaaaatttt cattcttgaa ggctcagtat tgtgagttta taagagataa tagacataaa    29460

agtgtaatga tttcattgca aataaaaaaa ggcccctttg cacctgatat ctccatcatt    29520

tttctagaat tttgtgcaca catgccttgc actacttggt gatgataaag atttccagat    29580

ctttgcacag aataaggctt tgctttagat cagaattttg gatgtactta gtatacattc    29640

atcttttaaa taatctattt acattttcat actttccaaa atacagatat attttatttt    29700

atttatatat ttatttaatt tattttttga gatggagtct ctctctgttg cccagagtag    29760

agtgcagtgg cacaatcttg gttcactgca gcctctgcct cccgggttca agcgattctc    29820

ctgcctcagc ctcctgagta gctgggatta caggcgcgcg ccacacctgg ctaatttttg    29880

tatttttagt agagacgagg tttcatcatg ttggtcaggc tggtctcgaa ctcctggcct    29940

caagggatcc acccacctcg gcctcccgaa gtgctgggat tacaggtgtg ggccactgtg    30000

cccagctgta tagagatatt ttaaacaaca ctaaagtcct cctactttga ctaattagaa    30060

gagcattaga agatcagcct gacttcttga cagttctgaa tttagtggag caatgaggtt    30120

cagctttggt gaatgagctt aatttttcca tgataaactg ctagtttctt cccactacag    30180

tgtctctcaa aaatgggaca gcaacattct ttttgttttc acttgcagta agcatgatgc    30240

aattacataa atgtacactt ttcaatttgt taaatagaat cttcagagat tcactactgc    30300

cgctattggt gatgaaaaat taccagaagg aggaattagg taggagaaaa tgtgtcctat    30360

gtatttcctt cccagttctt tgaaagagag tgataggaaa aaggaacact attgaaggaa    30420

ggactgccca gtttcaaaca ggtatttatt tttctctcct aggcttcccc tgcaggatgt    30480

ttggcgcatc tatagtggca ttttaaatct gtcagacatt acaaaagata cacctttctc    30540

acaaataaaa gagattatta ttcaccaaaa ctataaagtc tcagaaggga atcatgatat    30600

cgccttgata aaactccagg ctcctttgaa ttacactggt atgtagcata tgtaagaagg    30660

tggagagcag aattgcgctg gttgatattt tcatatcagt ttgaacaaga gggcagacct    30720

agagagactg tcgtcgtttt ctgactggtg gagttgaggg aaacgtgagg gttgctggga    30780

agtgaagacc ccgcgacttg ccgtgaaatc tcttctactt aaagagcaag acatgtgaat    30840

taattctttc agggagggat acaactgcat gcaggtgatg gaaataatgg gcgtgggaaa    30900

tgtctgtgcc gtctgagagg cactgggctt gctttgacaa gagtagcaga actgtcattg    30960

ctttgggctt agggatattc gaatgtgtga gggcaagtgg gatcagatat ctacttccag    31020

gtataatttg ggtaggaaag agactcatgc agaaagaagc cctggaaggc cagagcatcg    31080

tggtcagagg tgttgccttt ggagggtcat tgctgccagg agccgaatac ccactgtatc    31140

caataacatt catggtcagg aatggtggct cacacctgta atcccaacac tttgggatgc    31200

ccaggtggga ggattgcttg aggccaggag tttgagacca gcctgggcaa cacagtgaga    31260

ccccgtctct acataaaatt agaaaaaaac aattaactgg gtgtggtggt gtgcacctgt    31320

agtcccagct agtcaagagg ctgagacaag aggatctctt gagcccagga gctcaaggct    31380

gtagtgagcc aagatcgtgc cactgcacac aaacaattat gtgacctcgg gcaagttgct    31440

ttacctcttt acacctctta atttccttat ctgtaaaatg aggatgataa tttcttcctg    31500

ggtctgttgt aataattaat acatcaaagc acttcatgtc tggaacagtg aagataccct    31560

gctatgacta ttaaggatag tatacatgga ataagacaca ggaacttcta aatgcttttg    31620

accatagatt taggttctga gttttaagaa tttaactcag gaaattgtaa caccaaaaat    31680

gtcatgtgaa aaatggtggt gacaaatttt cttgaatcat tagccttaga ggttgggcag    31740

aaagcaaaaa attattcttg atgctactct atagaaagag aagacagaaa aagagaaaga    31800

tgtattttta aagtctatat ccataacttt atttgaccaa actctaattt aaaaattatg    31860

tttcagaatt ccaaaaacca atatgcctac cttccaaagg tgacacaagc acaatttata    31920

ccaactgttg ggtaaccgga tggggcttct cgaaggagaa aggtaagcat gacgctttaa    31980

atattgcttc tagagtaagt ctcacatgtt gaaatacatg gagtgggtcg ttttaatcgg    32040

tttctgtctg aaattatatc taaactcttt atctttccta tctatttatt cccaaatatt    32100

tattcagtta ttcttaaaaa atgtattttt gctttggctt gaaaaaaaat tttagggaga    32160

cttttaagca tcttacttca ttataaagat cagttgcttg actttgcatg aagcagattg    32220

ggcccttcta gggctgacaa gcccgtgcaa gaccacccgc tcctcagtgt tagtagcgtt    32280

cccgtctccc aaaaccatgt tctcccttga tgctaatggc cgggagcaca ggcaggtgtg    32340

tcgtctcact atggagaata atatttgtgt cattctttac agaagaaggt agcttgccaa    32400

actgtctcca tctttcccga ttcagtcttt tgttcaagta attcacattt ttagattttt    32460

tattggtaat ctgagacaag aagaaattta aagtaatctt cactaagcca tgaaagctcc    32520

caacattgtt ctccatgaga gatgctggcc tgcatttatt caaaaacaaa agacccctct    32580

gttgccaaag ctcggagggc ttttcagaaa cgatatagtt gtaaattata attttgaata    32640

tataaagcaa aaaaatgaaa agtgagaact tccaggcttt ggattgttgt aggtgataaa    32700

tataaaatgg gatttctggg gggctgctac tgagatgagg ggatggcaga aaacatggaa    32760

gcaaggtctc tggtcagccc agggtgctgg gcttgtccca acaccacgta ggcaataaga    32820

ggacagtaca gggtgccgtc tctctccctc ttcctctctc tgtctctctc tctctgtgtg    32880

tgtgtgtgtg tgtgtgtgta acactacctt cccaattttt actgtctatt tgtattcaaa    32940

gataaggtcc ttatgaaaaa tacactgctc tgattcactt taaaacttat ttccatattt    33000

attatttatt gtgggaataa taatattccc aatattatta tttattattt aagttattat    33060

tattaacttc cctctgaggt tatatattgg ttactcacag gtgaaatcca aaatattcta    33120

caaaaggtaa atattccttt ggtaacaaat gaagaatgcc agaaaagata tcaagattat    33180

aaaataaccc aacggatggt ctgtgctggc tataaagaag ggggaaaaga tgcttgtaag    33240

gtaactcatg agattatgaa aaacacaata ggctgcttga gaaaattcat ttcaaaatat    33300

attttccaat agcataattc aatcatagtt tttaaaaaaa ttcagagaca aatgatctga    33360

taaattgata agcaactttt aacaaattga atatacataa tatatattta tattatttat    33420

gatatatgtc acaatctatg catgtgctat ttaagagggg caaatataca tgcaataatt    33480

gtgctagaat ataaaaacat tagacttcat cattgggatg atgatatcaa gatttctttg    33540

ttagatttat ttcagataga aaaggggata cgaaaaatgc aggcacatga gatacttgga    33600

gaactttaag aaagagtgag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtctggc    33660

aagcaaggtc ttgcacacac acagcacttt gggaggccaa tgcaggtgga tcacttgagc    33720

ctaggaattt gagaccagtc tgggcaatgt gatgaaaccc atctctacaa aaaaatatga    33780

aagtatctgt gtgtgtgtgt tgctgtgtag tggactacag aactttagag gcagtcactt    33840

atttgaatcc cattgtcgta actttctact attttatttt tccactgtga ctcagggaga    33900

ttcaggtggt cccttagttt gcaaacacaa tggaatgtgg cgtttggtgg gcatcaccag    33960

ctggggtgaa ggctgtgccc gcagggagca acctggtgtc tacaccaaag tcgctgagta    34020

catggactgg attttagaga aaacacagag cagtgatgga aaagctcaga tgcagtcacc    34080

agcatgagaa gcagtccaga gtctaggcaa tttttacaac ctgagttcaa gtcaaattct    34140

gagcctgggg ggtcctcatc tgcaaagcat ggagagtggc atcttctttg catcctaagg    34200

acgaaaaaca cagtgcactc agagctgctg aggacaatgt ctggctgaag cccgctttca    34260

gcacgccgta accaggggct gacaatgcga ggtcgcaact gagatctcca tgactgtgtg    34320

ttgtgaaata aaatggtgaa agatcacgat tagcaagtgt tttcttctgg ttgtgaaaca    34380

gaactgaaag taagtggttg aggttccagc acagttcctg ggatccctct aattgcactg    34440

cttcctctgg aactcagtat atctcaaaga tgtaatttcc tctccgtgct gcacctggtc    34500

ggccactgaa acccactatt gcctgcttca cgtgtggcaa agagctagcg ggcttgggtt    34560

ttgttctgcc gagaggaagg gagaacaccc acttttataa gaaagagatg ggttacctga    34620

acccatgggc acctttgcct cttggcctcc taactttgct accagggcat ggctaggagg    34680

gtccaggctg cgcgtgctga ggagctcgag gggctgcagc attgcacagc cttcatggca    34740

ggcaaggaat ctgctttgca aggggcatta gccctggagg ctcagtggat atgggctatt    34800

gcaatagtaa ttcaaggagc atttttaggc ctggcgtggt ggctcacgcc tgtaattcca    34860

acagtttagg agatcaaggc aggtggatca cttgagcata ggagttcgag actagcctgg    34920

ccaatgtgac gaaaccccat ctccacaaaa attagctggg catggtggtg cgcacctgta    34980

atcccagctc ccccagaagc tgaggcagga ggaccgcttg agcccgggga tgtcgtggct    35040

gcagtgagct gagatggcac cactgcatca ctgcattcca gcctgggcaa cagagtgaga    35100

ctgtctcaaa aaaaggaagc attgttaggt ataaattatt attattatta ttattagtag    35160

tagtagtagt agtagtagta ctgagacgga gtcttgctct gttgcccagg ctggagtgca    35220

gtggtgcaat cttggctcac tgcaatctct gcctcccggg ttcacgccat tctcctgcct    35280

cagcctccgg agtagctggg actacaggca cccgccactg tgcttggcta attttttgta    35340

tttttagtag agacgggttt caccatgtta gccagaatgg tctcgatctg ctgaccttgt    35400

gatccacccg cctcggcctc ccaaagtgct gggattacag gcttgagcca ccacacccag    35460

ccctgttagg tataaattat ttcataaaat tcagacttgt aaatttatgg tagcctttgg    35520

aatgggtgat agatgtccta tgccacacaa attcctcaca tgccgaggct caccgtaact    35580

gataccagct cgcttgattc agttcagtta aactgaacaa catttacaca gaattggcga    35640

tttacaaaat cttatgtaag ttaagtagaa aaacagaaaa aagttttctg aaagagtttg    35700

ggtttttcct tcaatgctca agacagaggt ccccaacctt tttggcacca gggaccagtt    35760

ttgtggaaga cagtttttcc atggaccagc atggtggtgg gggatgattc tggaatgatt    35820

caagtgcatg acatttatta tgcactttat ttctattatt actacattgt aatatataat    35880

gaaataatta tgcaactcac cataatgtag aatcagtggg agctctgagc ttgttttcct    35940

gcaactagac agtcccatct gagggtgatg ggagacagtg acagatcatc aggcattaga    36000

ttctcataag gagcctagat ccctcacatg tgcagttcat aacagggttt gagctcctat    36060

gagagtctca tgctgctgcg gatctggcag gaggcagagc tcaggcggtt atgcttgctg    36120

gcctgccact cacctcctgc tgtgcggcct ggctgctaac aggccatgga ccaggtactg    36180

ttctgggccc cgggggttgg gaacccctgc tcagagacac accgggtggt aggaggagct    36240

aaaggtggag agggtgaagg aaaatatgag gtctgggcta tccacaaacc agatagcagg    36300

aaactgaaga gttaaacatt tacttcagaa ttgaatggct tttgtaaaat ctggctagat    36360

tccatgaaac gattttaaaa atgcactatt taaattttgc ctttgcatgc gatgaagaca    36420

ttagtctttg ttcatgtgga tgttttttta tgtttaaaag ggaaaaaatg gtttgcaatg    36480

aaacttttat ctcagtcttt gagtattgat catggggtgt tggaacagga ctttggaatg    36540

cttgcagggt aaacctttgg cctctgttag tcagggaatg acctagtttg gcaaaacaga    36600

ggagagtttt gaaatatgga actttcccga ggcatacatt gtcattttaa agtggtcaat    36660

caaagcccag taggactggg ctggtgtctt ggtgactcac tgtgtgctca tatacagggg    36720

taactgagga gcccttcaca caggtctagc ctcgtgggac taaaaagtgt gacatgggct    36780

aggaaaatgc gaggctggga tgccttcact cccatgagga agcgtgacgg gaggaggcgt    36840

gggccactgg cagttctact tcacaaaggc tgctggcagt gtcaatcctg caagctggcc    36900

ttgccctcct gtggcggcag tgtacacgtg gcatgcaagc acatgcacaa gccacctggc    36960

tccaaggtca gccaagggct ccaacatctg tctcagtccc                          37000


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  3
tgcaagtctc ttggcaaaca                                                   20


