                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Regulating Chimeric Antigen Receptors

<130>  16010-024WO1

<150>  US 62/456,649
<151>  2017-02-08

<150>  US 62/457,124
<151>  2017-02-09

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP12 derived amino acid sequence with a mutation of 
       phenylalanine (F) at amino acid position 36 to valine (V)

<400>  2

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  3
<211>  1362
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu 
705                 710                 715                 720 


Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                 730                 735     


Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                 745                 750         


Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                 775                 780                 


Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                 790                 795                 800 


Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                 810                 815     


Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln 
            820                 825                 830         


Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro 
        835                 840                 845             


Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                 855                 860                 


Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                 870                 875                 880 


Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln 
                885                 890                 895     


Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                 905                 910         


Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met 
        915                 920                 925             


Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu 
    930                 935                 940                 


Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                 950                 955                 960 


Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                 985                 990         


Pro Pro Arg Pro Val His Leu Gln  Pro Met Gln Phe Ser  Thr His Ile 
        995                 1000                 1005             


Gln Gln  Pro Pro Pro Pro Gln  Gly Gln Gln Pro Pro  His Pro Pro 
    1010                 1015                 1020             


Pro Gly  Gln Gln Pro Pro Pro  Pro Gln Pro Ala Lys  Pro Gln Gln 
    1025                 1030                 1035             


Val Ile  Gln His His His Ser  Pro Arg His His Lys  Ser Asp Pro 
    1040                 1045                 1050             


Tyr Ser  Thr Gly His Leu Arg  Glu Ala Pro Ser Pro  Leu Met Ile 
    1055                 1060                 1065             


His Ser  Pro Gln Met Ser Gln  Phe Gln Ser Leu Thr  His Gln Ser 
    1070                 1075                 1080             


Pro Pro  Gln Gln Asn Val Gln  Pro Lys Lys Gln Glu  Leu Arg Ala 
    1085                 1090                 1095             


Ala Ser  Val Val Gln Pro Gln  Pro Leu Val Val Val  Lys Glu Glu 
    1100                 1105                 1110             


Lys Ile  His Ser Pro Ile Ile  Arg Ser Glu Pro Phe  Ser Pro Ser 
    1115                 1120                 1125             


Leu Arg  Pro Glu Pro Pro Lys  His Pro Glu Ser Ile  Lys Ala Pro 
    1130                 1135                 1140             


Val His  Leu Pro Gln Arg Pro  Glu Met Lys Pro Val  Asp Val Gly 
    1145                 1150                 1155             


Arg Pro  Val Ile Arg Pro Pro  Glu Gln Asn Ala Pro  Pro Pro Gly 
    1160                 1165                 1170             


Ala Pro  Asp Lys Asp Lys Gln  Lys Gln Glu Pro Lys  Thr Pro Val 
    1175                 1180                 1185             


Ala Pro  Lys Lys Asp Leu Lys  Ile Lys Asn Met Gly  Ser Trp Ala 
    1190                 1195                 1200             


Ser Leu  Val Gln Lys His Pro  Thr Thr Pro Ser Ser  Thr Ala Lys 
    1205                 1210                 1215             


Ser Ser  Ser Asp Ser Phe Glu  Gln Phe Arg Arg Ala  Ala Arg Glu 
    1220                 1225                 1230             


Lys Glu  Glu Arg Glu Lys Ala  Leu Lys Ala Gln Ala  Glu His Ala 
    1235                 1240                 1245             


Glu Lys  Glu Lys Glu Arg Leu  Arg Gln Glu Arg Met  Arg Ser Arg 
    1250                 1255                 1260             


Glu Asp  Glu Asp Ala Leu Glu  Gln Ala Arg Arg Ala  His Glu Glu 
    1265                 1270                 1275             


Ala Arg  Arg Arg Gln Glu Gln  Gln Gln Gln Gln Arg  Gln Glu Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Ala Ala Ala Val Ala  Ala Ala Ala 
    1295                 1300                 1305             


Thr Pro  Gln Ala Gln Ser Ser  Gln Pro Gln Ser Met  Leu Asp Gln 
    1310                 1315                 1320             


Gln Arg  Glu Leu Ala Arg Lys  Arg Glu Gln Glu Arg  Arg Arg Arg 
    1325                 1330                 1335             


Glu Ala  Met Ala Ala Thr Ile  Asp Met Asn Phe Gln  Ser Asp Leu 
    1340                 1345                 1350             


Leu Ser  Ile Phe Glu Glu Asn  Leu Phe 
    1355                 1360         


<210>  4
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  5
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  estrogen receptor ligand-binding domain

<400>  5

Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
1               5                   10                  15      


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
            20                  25                  30          


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
        35                  40                  45              


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
    50                  55                  60                  


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
65                  70                  75                  80  


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
                85                  90                  95      


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
            100                 105                 110         


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
        115                 120                 125             


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
    130                 135                 140                 


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
145                 150                 155                 160 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
                165                 170                 175     


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
            180                 185                 190         


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
        195                 200                 205             


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
    210                 215                 220                 


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
225                 230                 235                 240 


Asp Ala His Arg Leu 
                245 


<210>  6
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  7
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


<210>  8
<211>  165
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Asn Ser Glu Ser Val Arg Ile Tyr Leu Val Ala Ala Met Gly Ala 
1               5                   10                  15      


Asn Arg Val Ile Gly Asn Gly Pro Asn Ile Pro Trp Lys Ile Pro Gly 
            20                  25                  30          


Glu Gln Lys Ile Phe Arg Arg Leu Thr Glu Gly Lys Val Val Val Met 
        35                  40                  45              


Gly Arg Lys Thr Phe Glu Ser Ile Gly Lys Pro Leu Pro Asn Arg His 
    50                  55                  60                  


Thr Leu Val Ile Ser Arg Gln Ala Asn Tyr Arg Ala Thr Gly Cys Val 
65                  70                  75                  80  


Val Val Ser Thr Leu Ser His Ala Ile Ala Leu Ala Ser Glu Leu Gly 
                85                  90                  95      


Asn Glu Leu Tyr Val Ala Gly Gly Ala Glu Ile Tyr Thr Leu Ala Leu 
            100                 105                 110         


Pro His Ala His Gly Val Phe Leu Ser Glu Val His Gln Thr Phe Glu 
        115                 120                 125             


Gly Asp Ala Phe Phe Pro Met Leu Asn Glu Thr Glu Phe Glu Leu Val 
    130                 135                 140                 


Ser Thr Glu Thr Ile Gln Ala Val Ile Pro Tyr Thr His Ser Val Tyr 
145                 150                 155                 160 


Ala Arg Arg Asn Gly 
                165 


<210>  9
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence deried from a bacterial dehalogenase

<400>  9

Met Ala Glu Ile Gly Thr Gly Phe Pro Phe Asp Pro His Tyr Val Glu 
1               5                   10                  15      


Val Leu Gly Glu Arg Met His Tyr Val Asp Val Gly Pro Arg Asp Gly 
            20                  25                  30          


Thr Pro Val Leu Phe Leu His Gly Asn Pro Thr Ser Ser Tyr Val Trp 
        35                  40                  45              


Arg Asn Ile Ile Pro His Val Ala Pro Thr His Arg Cys Ile Ala Pro 
    50                  55                  60                  


Asp Leu Ile Gly Met Gly Lys Ser Asp Lys Pro Asp Leu Gly Tyr Phe 
65                  70                  75                  80  


Phe Asp Asp His Val Arg Phe Met Asp Ala Phe Ile Glu Ala Leu Gly 
                85                  90                  95      


Leu Glu Glu Val Val Leu Val Ile His Asp Trp Gly Ser Ala Leu Gly 
            100                 105                 110         


Phe His Trp Ala Lys Arg Asn Pro Glu Arg Val Lys Gly Ile Ala Phe 
        115                 120                 125             


Met Glu Phe Ile Arg Pro Ile Pro Thr Trp Asp Glu Trp Pro Glu Phe 
    130                 135                 140                 


Ala Arg Glu Thr Phe Gln Ala Phe Arg Thr Thr Asp Val Gly Arg Lys 
145                 150                 155                 160 


Leu Ile Ile Asp Gln Asn Val Phe Ile Glu Gly Thr Leu Pro Met Gly 
                165                 170                 175     


Val Val Arg Pro Leu Thr Glu Val Glu Met Asp His Tyr Arg Glu Pro 
            180                 185                 190         


Phe Leu Asn Pro Val Asp Arg Glu Pro Leu Trp Arg Phe Pro Asn Glu 
        195                 200                 205             


Leu Pro Ile Ala Gly Glu Pro Ala Asn Ile Val Ala Leu Val Glu Glu 
    210                 215                 220                 


Tyr Met Asp Trp Leu His Gln Ser Pro Val Pro Lys Leu Leu Phe Trp 
225                 230                 235                 240 


Gly Thr Pro Gly Val Leu Ile Pro Pro Ala Glu Ala Ala Arg Leu Ala 
                245                 250                 255     


Lys Ser Leu Pro Asn Cys Lys Ala Val Asp Ile Gly Pro Gly Leu Asn 
            260                 265                 270         


Leu Leu Gln Glu Asp Asn Pro Asp Leu Ile Gly Ser Glu Ile Ala Arg 
        275                 280                 285             


Trp Leu Ser Thr Leu Glu Ile Ser Gly 
    290                 295         


<210>  10
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 scFv

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMCSF signal peptide

<400>  11

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to CD19 variable light chain (VL)

<400>  12

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Whitlow linker

<400>  13

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to CD19 variable heavy chain (VH)

<400>  14

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8 alpha chain hinge region

<400>  15

Ala Leu Ser Asn Ser Ile Tyr Phe Ser His Phe Val Pro Val Phe Leu 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            20                  25                  30          


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        35                  40                  45              


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    50                  55                  60      


<210>  16
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of the co-stimulatory CD28 protein

<400>  16

Lys Pro Phe Trp Val Leu Val Trp Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        35                  40                  45              


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    50                  55                  60                  


Ala Ala Tyr Arg Ser 
65                  


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta domain

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG derivative of FKBP12 with F36V mutation

<400>  18

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Val Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
                85                  90                  95      


Leu Ile Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  19
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-CAR-dTAG

<400>  19

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Leu Ser Asn Ser 
            260                 265                 270         


Ile Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Lys Pro Phe Trp Val Leu Val Trp 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    370                 375                 380                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly 
            500                 505                 510         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        515                 520                 525             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    530                 535                 540                 


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
545                 550                 555                 560 


Val Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                565                 570                 575     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            580                 585                 590         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro Asn Ala Thr 
        595                 600                 605             


Leu Ile Phe Asp Val Glu Leu Leu Lys Leu Glu 
    610                 615                 


<210>  20
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERB2 scFv variable light chain (VL)

<400>  20

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu 
    210             


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to ERB2 variable heavy chain (VH)

<400>  21

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  22
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to Erb-B2 variable heavy chain (VH)

<400>  22

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220     


<210>  23
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERB2-CAR-dTAG

<400>  23

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    210                 215                 220                 


Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln Thr Thr Ser 
225                 230                 235                 240 


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
                245                 250                 255     


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
            260                 265                 270         


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
    290                 295                 300                 


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
305                 310                 315                 320 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                325                 330                 335     


Ile Thr Ala Leu Ser Asn Ser Ile Tyr Phe Ser His Phe Val Pro Val 
            340                 345                 350         


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        355                 360                 365             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    370                 375                 380                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Lys 
385                 390                 395                 400 


Pro Phe Trp Val Leu Val Trp Gly Gly Val Leu Ala Cys Tyr Ser Leu 
                405                 410                 415     


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            420                 425                 430         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        435                 440                 445             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    450                 455                 460                 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
465                 470                 475                 480 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                485                 490                 495     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            500                 505                 510         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        515                 520                 525             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    530                 535                 540                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
545                 550                 555                 560 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                565                 570                 575     


Leu Pro Pro Arg Gly Gly Gly Gly Val Gln Val Glu Thr Ile Ser Pro 
            580                 585                 590         


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        595                 600                 605             


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
    610                 615                 620                 


Arg Asn Lys Pro Phe Lys Phe Val Leu Gly Lys Gln Glu Val Ile Arg 
625                 630                 635                 640 


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                645                 650                 655     


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            660                 665                 670         


Ile Ile Pro Pro Asn Ala Thr Leu Ile Phe Asp Val Glu Leu Leu Lys 
        675                 680                 685             


Leu Glu 
    690 


<210>  24
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  androgen receptor ligand-binding domain

<400>  24

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr 
225                 


<210>  25
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Retinoic Receptor ligand-binding domain

<400>  25

Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
1               5                   10                  15      


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
            20                  25                  30          


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
        35                  40                  45              


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
    50                  55                  60                  


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
                85                  90                  95      


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
            100                 105                 110         


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
        115                 120                 125             


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
    130                 135                 140                 


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
145                 150                 155                 160 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
                165                 170                 175     


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
            180                 185                 190         


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
        195                 200                 205             


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
    210                 215                 220                 


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
225                 230                 235             


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus of MDM2

<400>  26

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val 
            100                 105                 110 


<210>  27
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro 
    610                 615                 620                 


Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg 
625                 630                 635                 640 


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
                645                 650                 655     


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg 
            660                 665                 670         


Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe 
        675                 680                 685             


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu 
    690                 695                 700                 


Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro 
705                 710                 715                 720 


Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu 
                725                 730                 735     


Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys 
            740                 745                 750         


Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln 
        755                 760                 765             


Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Gly 
    


<210>  28
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln 
            180                 185                 190         


Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val 
        195                 200                 205             


Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile 
                245                 250                 255     


Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                 425                 430         


Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                 440                 445             


Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala 
    450                 455                 460                 


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                 490                 495     


Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                 505                 510         


Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                 520                 525             


Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr 
    530                 535                 540                 


Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser 
545                 550                 555                 560 


Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu 
                565                 570                 575     


Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu 
            580                 585                 590         


Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp 
        595                 600                 605             


Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr 
    610                 615                 620                 


Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys 
625                 630                 635                 640 


Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser 
                645                 650                 655     


Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu 
            660                 665                 670         


Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys 
        675                 680                 685             


Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser 
    690                 695                 700                 


Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Asp Ser Ser Asp Ser Glu 
                725     


<210>  29
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Leu Pro Ser Arg Gln Thr Ala Ile Ile Val Asn Pro Pro Pro 
1               5                   10                  15      


Pro Glu Tyr Ile Asn Thr Lys Lys Asn Gly Arg Leu Thr Asn Gln Leu 
            20                  25                  30          


Gln Tyr Leu Gln Lys Val Val Leu Lys Asp Leu Trp Lys His Ser Phe 
        35                  40                  45              


Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val Lys Leu Gln Leu Pro 
    50                  55                  60                  


Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp Leu Asn Thr Ile Lys 
65                  70                  75                  80  


Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala Ser Glu Cys Ile Glu 
                85                  90                  95      


Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu Tyr Asn Lys Pro Gly 
            100                 105                 110         


Asp Asp Ile Val Leu Met Ala Gln Ala Leu Glu Lys Leu Phe Met Gln 
        115                 120                 125             


Lys Leu Ser Gln Met Pro Gln Glu Glu Gln Val Val Gly Val Lys Glu 
    130                 135                 140                 


Arg Ile Lys Lys Gly Thr Gln Gln Asn Ile Ala Val Ser Ser Ala Lys 
145                 150                 155                 160 


Glu Lys Ser Ser Pro Ser Ala Thr Glu Lys Val Phe Lys Gln Gln Glu 
                165                 170                 175     


Ile Pro Ser Val Phe Pro Lys Thr Ser Ile Ser Pro Leu Asn Val Val 
            180                 185                 190         


Gln Gly Ala Ser Val Asn Ser Ser Ser Gln Thr Ala Ala Gln Val Thr 
        195                 200                 205             


Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Ala Thr Ser Ala 
    210                 215                 220                 


Val Lys Ala Ser Ser Glu Phe Ser Pro Thr Phe Thr Glu Lys Ser Val 
225                 230                 235                 240 


Ala Leu Pro Pro Ile Lys Glu Asn Met Pro Lys Asn Val Leu Pro Asp 
                245                 250                 255     


Ser Gln Gln Gln Tyr Asn Val Val Lys Thr Val Lys Val Thr Glu Gln 
            260                 265                 270         


Leu Arg His Cys Ser Glu Ile Leu Lys Glu Met Leu Ala Lys Lys His 
        275                 280                 285             


Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn Ala Leu 
    290                 295                 300                 


Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp Leu Gly 
305                 310                 315                 320 


Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala Tyr Lys 
                325                 330                 335     


Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys Tyr Asn 
            340                 345                 350         


Pro Pro Asp His Glu Val Val Thr Met Ala Arg Met Leu Gln Asp Val 
        355                 360                 365             


Phe Glu Thr His Phe Ser Lys Ile Pro Ile Glu Pro Val Glu Ser Met 
    370                 375                 380                 


Pro Leu Cys Tyr Ile Lys Thr Asp Ile Thr Glu Thr Thr Gly Arg Glu 
385                 390                 395                 400 


Asn Thr Asn Glu Ala Ser Ser Glu Gly Asn Ser Ser Asp Asp Ser Glu 
                405                 410                 415     


Asp Glu Arg Val Lys Arg Leu Ala Lys Leu Gln Glu Gln Leu Lys Ala 
            420                 425                 430         


Val His Gln Gln Leu Gln Val Leu Ser Gln Val Pro Phe Arg Lys Leu 
        435                 440                 445             


Asn Lys Lys Lys Glu Lys Ser Lys Lys Glu Lys Lys Lys Glu Lys Val 
    450                 455                 460                 


Asn Asn Ser Asn Glu Asn Pro Arg Lys Met Cys Glu Gln Met Arg Leu 
465                 470                 475                 480 


Lys Glu Lys Ser Lys Arg Asn Gln Pro Lys Lys Arg Lys Gln Gln Phe 
                485                 490                 495     


Ile Gly Leu Lys Ser Glu Asp Glu Asp Asn Ala Lys Pro Met Asn Tyr 
            500                 505                 510         


Asp Glu Lys Arg Gln Leu Ser Leu Asn Ile Asn Lys Leu Pro Gly Asp 
        515                 520                 525             


Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu 
    530                 535                 540                 


Ser Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys 
545                 550                 555                 560 


Ala Ser Thr Leu Arg Glu Leu Glu Lys Tyr Val Ser Ala Cys Leu Arg 
                565                 570                 575     


Lys Arg Pro Leu Lys Pro Pro Ala Lys Lys Ile Met Met Ser Lys Glu 
            580                 585                 590         


Glu Leu His Ser Gln Lys Lys Gln Glu Leu Glu Lys Arg Leu Leu Asp 
        595                 600                 605             


Val Asn Asn Gln Leu Asn Ser Arg Lys Arg Gln Thr Lys Ser Asp Lys 
    610                 615                 620                 


Thr Gln Pro Ser Lys Ala Val Glu Asn Val Ser Arg Leu Ser Glu Ser 
625                 630                 635                 640 


Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Glu Ser Ser Ser Ser Asp 
                645                 650                 655     


Leu Ser Ser Ser Asp Ser Ser Asp Ser Glu Ser Glu Met Phe Pro Lys 
            660                 665                 670         


Phe Thr Glu Val Lys Pro Asn Asp Ser Pro Ser Lys Glu Asn Val Lys 
        675                 680                 685             


Lys Met Lys Asn Glu Cys Ile Pro Pro Glu Gly Arg Thr Gly Val Thr 
    690                 695                 700                 


Gln Ile Gly Tyr Cys Val Gln Asp Thr Thr Ser Ala Asn Thr Thr Leu 
705                 710                 715                 720 


Val His Gln Thr Thr Pro Ser His Val Met Pro Pro Asn His His Gln 
                725                 730                 735     


Leu Ala Phe Asn Tyr Gln Glu Leu Glu His Leu Gln Thr Val Lys Asn 
            740                 745                 750         


Ile Ser Pro Leu Gln Ile Leu Pro Pro Ser Gly Asp Ser Glu Gln Leu 
        755                 760                 765             


Ser Asn Gly Ile Thr Val Met His Pro Ser Gly Asp Ser Asp Thr Thr 
    770                 775                 780                 


Met Leu Glu Ser Glu Cys Gln Ala Pro Val Gln Lys Asp Ile Lys Ile 
785                 790                 795                 800 


Lys Asn Ala Asp Ser Trp Lys Ser Leu Gly Lys Pro Val Lys Pro Ser 
                805                 810                 815     


Gly Val Met Lys Ser Ser Asp Glu Leu Phe Asn Gln Phe Arg Lys Ala 
            820                 825                 830         


Ala Ile Glu Lys Glu Val Lys Ala Arg Thr Gln Glu Leu Ile Arg Lys 
        835                 840                 845             


His Leu Glu Gln Asn Thr Lys Glu Leu Lys Ala Ser Gln Glu Asn Gln 
    850                 855                 860                 


Arg Asp Leu Gly Asn Gly Leu Thr Val Glu Ser Phe Ser Asn Lys Ile 
865                 870                 875                 880 


Gln Asn Lys Cys Ser Gly Glu Glu Gln Lys Glu His Gln Gln Ser Ser 
                885                 890                 895     


Glu Ala Gln Asp Lys Ser Lys Leu Trp Leu Leu Lys Asp Arg Asp Leu 
            900                 905                 910         


Ala Arg Gln Lys Glu Gln Glu Arg Arg Arg Arg Glu Ala Met Val Gly 
        915                 920                 925             


Thr Ile Asp Met Thr Leu Gln Ser Asp Ile Met Thr Met Phe Glu Asn 
    930                 935                 940                 


Asn Phe Asp 
945         


<210>  30
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  31
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Thr Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Thr Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210>  32
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  33
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  33

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  34
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Asn Tyr Lys Leu Thr Tyr Phe Asn Met Arg Gly Arg Ala Glu 
1               5                   10                  15      


Ile Ile Arg Tyr Ile Phe Ala Tyr Leu Asp Ile Gln Tyr Glu Asp His 
            20                  25                  30          


Arg Ile Glu Gln Ala Asp Trp Pro Glu Ile Lys Ser Thr Leu Pro Phe 
        35                  40                  45              


Gly Lys Ile Pro Ile Leu Glu Val Asp Gly Leu Thr Leu His Gln Ser 
    50                  55                  60                  


Leu Ala Ile Ala Arg Tyr Leu Thr Lys Asn Thr Asp Leu Ala Gly Asn 
65                  70                  75                  80  


Thr Glu Met Glu Gln Cys His Val Asp Ala Ile Val Asp Thr Leu Asp 
                85                  90                  95      


Asp Phe Met Ser Cys Phe Pro Trp Ala Glu Lys Lys Gln Asp Val Lys 
            100                 105                 110         


Glu Gln Met Phe Asn Glu Leu Leu Thr Tyr Asn Ala Pro His Leu Met 
        115                 120                 125             


Gln Asp Leu Asp Thr Tyr Leu Gly Gly Arg Glu Trp Leu Ile Gly Asn 
    130                 135                 140                 


Ser Val Thr Trp Ala Asp Phe Tyr Trp Glu Ile Cys Ser Thr Thr Leu 
145                 150                 155                 160 


Leu Val Phe Lys Pro Asp Leu Leu Asp Asn His Pro Arg Leu Val Thr 
                165                 170                 175     


Leu Arg Lys Lys Val Gln Ala Ile Pro Ala Val Ala Asn Trp Ile Lys 
            180                 185                 190         


Arg Arg Pro Gln Thr Lys Leu 
        195                 


<210>  35
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  36
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ala Pro Gly Pro Leu Pro Ala Ala Ala Leu Ser Pro Gly Ala 
1               5                   10                  15      


Pro Thr Pro Arg Glu Leu Met His Gly Val Ala Gly Val Thr Ser Arg 
            20                  25                  30          


Ala Gly Arg Asp Arg Glu Ala Gly Ser Val Leu Pro Ala Gly Asn Arg 
        35                  40                  45              


Gly Ala Arg Lys Ala Ser Arg Arg Ser Ser Ser Arg Ser Met Ser Arg 
    50                  55                  60                  


Asp Asn Lys Phe Ser Lys Lys Asp Cys Leu Ser Ile Arg Asn Val Val 
65                  70                  75                  80  


Ala Ser Ile Gln Thr Lys Glu Gly Leu Asn Leu Lys Leu Ile Ser Gly 
                85                  90                  95      


Asp Val Leu Tyr Ile Trp Ala Asp Val Ile Val Asn Ser Val Pro Met 
            100                 105                 110         


Asn Leu Gln Leu Gly Gly Gly Pro Leu Ser Arg Ala Phe Leu Gln Lys 
        115                 120                 125             


Ala Gly Pro Met Leu Gln Lys Glu Leu Asp Asp Arg Arg Arg Glu Thr 
    130                 135                 140                 


Glu Glu Lys Val Gly Asn Ile Phe Met Thr Ser Gly Cys Asn Leu Asp 
145                 150                 155                 160 


Cys Lys Ala Val Leu His Ala Val Ala Pro Tyr Trp Asn Asn Gly Ala 
                165                 170                 175     


Glu Thr Ser Trp Gln Ile Met Ala Asn Ile Ile Lys Lys Cys Leu Thr 
            180                 185                 190         


Thr Val Glu Val Leu Ser Phe Ser Ser Ile Thr Phe Pro Met Ile Gly 
        195                 200                 205             


Thr Gly Ser Leu Gln Phe Pro Lys Ala Val Phe Ala Lys Leu Ile Leu 
    210                 215                 220                 


Ser Glu Val Phe Glu Tyr Ser Ser Ser Thr Arg Pro Ile Thr Ser Pro 
225                 230                 235                 240 


Leu Gln Glu Val His Phe Leu Val Tyr Thr Asn Asp Asp Glu Gly Cys 
                245                 250                 255     


Gln Ala Phe Leu Asp Glu Phe Thr Asn Trp Ser Arg Ile Asn Pro Asn 
            260                 265                 270         


Lys Ala Arg Ile Pro Met Ala Gly Asp Thr Gln Gly Val Val Gly Thr 
        275                 280                 285             


Val Ser Lys Pro Cys Phe Thr Ala Tyr Glu Met Lys Ile Gly Ala Ile 
    290                 295                 300                 


Thr Phe Gln Val Ala Thr Gly Asp Ile Ala Thr Glu Gln Val Asp Val 
305                 310                 315                 320 


Ile Val Asn Ser Thr Ala Arg Thr Phe Asn Arg Lys Ser Gly Val Ser 
                325                 330                 335     


Arg Ala Ile Leu Glu Gly Ala Gly Gln Ala Val Glu Ser Glu Cys Ala 
            340                 345                 350         


Val Leu Ala Ala Gln Pro His Arg Asp Phe Ile Ile Thr Pro Gly Gly 
        355                 360                 365             


Cys Leu Lys Cys Lys Ile Ile Ile His Val Pro Gly Gly Lys Asp Val 
    370                 375                 380                 


Arg Lys Thr Val Thr Ser Val Leu Glu Glu Cys Glu Gln Arg Lys Tyr 
385                 390                 395                 400 


Thr Ser Val Ser Leu Pro Ala Ile Gly Thr Gly Asn Ala Gly Lys Asn 
                405                 410                 415     


Pro Ile Thr Val Ala Asp Asn Ile Ile Asp Ala Ile Val Asp Phe Ser 
            420                 425                 430         


Ser Gln His Ser Thr Pro Ser Leu Lys Thr Val Lys Val Val Ile Phe 
        435                 440                 445             


Gln Pro Glu Leu Leu Asn Ile Phe Tyr Asp Ser Met Lys Lys Arg Asp 
    450                 455                 460                 


Leu Ser Ala Ser Leu Asn Phe Gln Ser Thr Phe Ser Met Thr Thr Cys 
465                 470                 475                 480 


Asn Leu Pro Glu His Trp Thr Asp Met Asn His Gln Leu Phe Cys Met 
                485                 490                 495     


Val Gln Leu Glu Pro Gly Gln Ser Glu Tyr Asn Thr Ile Lys Asp Lys 
            500                 505                 510         


Phe Thr Arg Thr Cys Ser Ser Tyr Ala Ile Glu Lys Ile Glu Arg Ile 
        515                 520                 525             


Gln Asn Ala Phe Leu Trp Gln Ser Tyr Gln Val Lys Lys Arg Gln Met 
    530                 535                 540                 


Asp Ile Lys Asn Asp His Lys Asn Asn Glu Arg Leu Leu Phe His Gly 
545                 550                 555                 560 


Thr Asp Ala Asp Ser Val Pro Tyr Val Asn Gln His Gly Phe Asn Arg 
                565                 570                 575     


Ser Cys Ala Gly Lys Asn Ala Val Ser Tyr Gly Lys Gly Thr Tyr Phe 
            580                 585                 590         


Ala Val Asp Ala Ser Tyr Ser Ala Lys Asp Thr Tyr Ser Lys Pro Asp 
        595                 600                 605             


Ser Asn Gly Arg Lys His Met Tyr Val Val Arg Val Leu Thr Gly Val 
    610                 615                 620                 


Phe Thr Lys Gly Arg Ala Gly Leu Val Thr Pro Pro Pro Lys Asn Pro 
625                 630                 635                 640 


His Asn Pro Thr Asp Leu Phe Asp Ser Val Thr Asn Asn Thr Arg Ser 
                645                 650                 655     


Pro Lys Leu Phe Val Val Phe Phe Asp Asn Gln Ala Tyr Pro Glu Tyr 
            660                 665                 670         


Leu Ile Thr Phe Thr Ala 
        675             


<210>  37
<211>  1801
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Val Pro Gly Ser Phe Pro Leu Leu Val Glu Gly Ser Trp Gly 
1               5                   10                  15      


Pro Asp Pro Pro Lys Asn Leu Asn Thr Lys Leu Gln Met Tyr Phe Gln 
            20                  25                  30          


Ser Pro Lys Arg Ser Gly Gly Gly Glu Cys Glu Val Arg Gln Asp Pro 
        35                  40                  45              


Arg Ser Pro Ser Arg Phe Leu Val Phe Phe Tyr Pro Glu Asp Val Arg 
    50                  55                  60                  


Gln Lys Val Leu Glu Arg Lys Asn His Glu Leu Val Trp Gln Gly Lys 
65                  70                  75                  80  


Gly Thr Phe Lys Leu Thr Val Gln Leu Pro Ala Thr Pro Asp Glu Ile 
                85                  90                  95      


Asp His Val Phe Glu Glu Glu Leu Leu Thr Lys Glu Ser Lys Thr Lys 
            100                 105                 110         


Glu Asp Val Lys Glu Pro Asp Val Ser Glu Glu Leu Asp Thr Lys Leu 
        115                 120                 125             


Pro Leu Asp Gly Gly Leu Asp Lys Met Glu Asp Ile Pro Glu Glu Cys 
    130                 135                 140                 


Glu Asn Ile Ser Ser Leu Val Ala Phe Glu Asn Leu Lys Ala Asn Val 
145                 150                 155                 160 


Thr Asp Ile Met Leu Ile Leu Leu Val Glu Asn Ile Ser Gly Leu Ser 
                165                 170                 175     


Asn Asp Asp Phe Gln Val Glu Ile Ile Arg Asp Phe Asp Val Ala Val 
            180                 185                 190         


Val Thr Phe Gln Lys His Ile Asp Thr Ile Arg Phe Val Asp Asp Cys 
        195                 200                 205             


Thr Lys His His Ser Ile Lys Gln Leu Gln Leu Ser Pro Arg Leu Leu 
    210                 215                 220                 


Glu Val Thr Asn Thr Ile Arg Val Glu Asn Leu Pro Pro Gly Ala Asp 
225                 230                 235                 240 


Asp Tyr Ser Leu Lys Leu Phe Phe Glu Asn Pro Tyr Asn Gly Gly Gly 
                245                 250                 255     


Arg Val Ala Asn Val Glu Tyr Phe Pro Glu Glu Ser Ser Ala Leu Ile 
            260                 265                 270         


Glu Phe Phe Asp Arg Lys Val Leu Asp Thr Ile Met Ala Thr Lys Leu 
        275                 280                 285             


Asp Phe Asn Lys Met Pro Leu Ser Val Phe Pro Tyr Tyr Ala Ser Leu 
    290                 295                 300                 


Gly Thr Ala Leu Tyr Gly Lys Glu Lys Pro Leu Ile Lys Leu Pro Ala 
305                 310                 315                 320 


Pro Phe Glu Glu Ser Leu Asp Leu Pro Leu Trp Lys Phe Leu Gln Lys 
                325                 330                 335     


Lys Asn His Leu Ile Glu Glu Ile Asn Asp Glu Met Arg Arg Cys His 
            340                 345                 350         


Cys Glu Leu Thr Trp Ser Gln Leu Ser Gly Lys Val Thr Ile Arg Pro 
        355                 360                 365             


Ala Ala Thr Leu Val Asn Glu Gly Arg Pro Arg Ile Lys Thr Trp Gln 
    370                 375                 380                 


Ala Asp Thr Ser Thr Thr Leu Ser Ser Ile Arg Ser Lys Tyr Lys Val 
385                 390                 395                 400 


Asn Pro Ile Lys Val Asp Pro Thr Met Trp Asp Thr Ile Lys Asn Asp 
                405                 410                 415     


Val Lys Asp Asp Arg Ile Leu Ile Glu Phe Asp Thr Leu Lys Glu Met 
            420                 425                 430         


Val Ile Leu Ala Gly Lys Ser Glu Asp Val Gln Ser Ile Glu Val Gln 
        435                 440                 445             


Val Arg Glu Leu Ile Glu Ser Thr Thr Gln Lys Ile Lys Arg Glu Glu 
    450                 455                 460                 


Gln Ser Leu Lys Glu Lys Met Ile Ile Ser Pro Gly Arg Tyr Phe Leu 
465                 470                 475                 480 


Leu Cys His Ser Ser Leu Leu Asp His Leu Leu Thr Glu Cys Pro Glu 
                485                 490                 495     


Ile Glu Ile Cys Tyr Asp Arg Val Thr Gln His Leu Cys Leu Lys Gly 
            500                 505                 510         


Pro Ser Ala Asp Val Tyr Lys Ala Lys Cys Glu Ile Gln Glu Lys Val 
        515                 520                 525             


Tyr Thr Met Ala Gln Lys Asn Ile Gln Val Ser Pro Glu Ile Phe Gln 
    530                 535                 540                 


Phe Leu Gln Gln Val Asn Trp Lys Glu Phe Ser Lys Cys Leu Phe Ile 
545                 550                 555                 560 


Ala Gln Lys Ile Leu Ala Leu Tyr Glu Leu Glu Gly Thr Thr Val Leu 
                565                 570                 575     


Leu Thr Ser Cys Ser Ser Glu Ala Leu Leu Glu Ala Glu Lys Gln Met 
            580                 585                 590         


Leu Ser Ala Leu Asn Tyr Lys Arg Ile Glu Val Glu Asn Lys Glu Val 
        595                 600                 605             


Leu His Gly Lys Lys Trp Lys Gly Leu Thr His Asn Leu Leu Lys Lys 
    610                 615                 620                 


Gln Asn Ser Ser Pro Asn Thr Val Ile Ile Asn Glu Leu Thr Ser Glu 
625                 630                 635                 640 


Thr Thr Ala Glu Val Ile Ile Thr Gly Cys Val Lys Glu Val Asn Glu 
                645                 650                 655     


Thr Tyr Lys Leu Leu Phe Asn Phe Val Glu Gln Asn Met Lys Ile Glu 
            660                 665                 670         


Arg Leu Val Glu Val Lys Pro Ser Leu Val Ile Asp Tyr Leu Lys Thr 
        675                 680                 685             


Glu Lys Lys Leu Phe Trp Pro Lys Ile Lys Lys Val Asn Val Gln Val 
    690                 695                 700                 


Ser Phe Asn Pro Glu Asn Lys Gln Lys Gly Ile Leu Leu Thr Gly Ser 
705                 710                 715                 720 


Lys Thr Glu Val Leu Lys Ala Val Asp Ile Val Lys Gln Val Trp Asp 
                725                 730                 735     


Ser Val Cys Val Lys Ser Val His Thr Asp Lys Pro Gly Ala Lys Gln 
            740                 745                 750         


Phe Phe Gln Asp Lys Ala Arg Phe Tyr Gln Ser Glu Ile Lys Arg Leu 
        755                 760                 765             


Phe Gly Cys Tyr Ile Glu Leu Gln Glu Asn Glu Val Met Lys Glu Gly 
    770                 775                 780                 


Gly Ser Pro Ala Gly Gln Lys Cys Phe Ser Arg Thr Val Leu Ala Pro 
785                 790                 795                 800 


Gly Val Val Leu Ile Val Gln Gln Gly Asp Leu Ala Arg Leu Pro Val 
                805                 810                 815     


Asp Val Val Val Asn Ala Ser Asn Glu Asp Leu Lys His Tyr Gly Gly 
            820                 825                 830         


Leu Ala Ala Ala Leu Ser Lys Ala Ala Gly Pro Glu Leu Gln Ala Asp 
        835                 840                 845             


Cys Asp Gln Ile Val Lys Arg Glu Gly Arg Leu Leu Pro Gly Asn Ala 
    850                 855                 860                 


Thr Ile Ser Lys Ala Gly Lys Leu Pro Tyr His His Val Ile His Ala 
865                 870                 875                 880 


Val Gly Pro Arg Trp Ser Gly Tyr Glu Ala Pro Arg Cys Val Tyr Leu 
                885                 890                 895     


Leu Arg Arg Ala Val Gln Leu Ser Leu Cys Leu Ala Glu Lys Tyr Lys 
            900                 905                 910         


Tyr Arg Ser Ile Ala Ile Pro Ala Ile Ser Ser Gly Val Phe Gly Phe 
        915                 920                 925             


Pro Leu Gly Arg Cys Val Glu Thr Ile Val Ser Ala Ile Lys Glu Asn 
    930                 935                 940                 


Phe Gln Phe Lys Lys Asp Gly His Cys Leu Lys Glu Ile Tyr Leu Val 
945                 950                 955                 960 


Asp Val Ser Glu Lys Thr Val Glu Ala Phe Ala Glu Ala Val Lys Thr 
                965                 970                 975     


Val Phe Lys Ala Thr Leu Pro Asp Thr Ala Ala Pro Pro Gly Leu Pro 
            980                 985                 990         


Pro Ala Ala Ala Gly Pro Gly Lys  Thr Ser Trp Glu Lys  Gly Ser Leu 
        995                 1000                 1005             


Val Ser  Pro Gly Gly Leu Gln  Met Leu Leu Val Lys  Glu Gly Val 
    1010                 1015                 1020             


Gln Asn  Ala Lys Thr Asp Val  Val Val Asn Ser Val  Pro Leu Asp 
    1025                 1030                 1035             


Leu Val  Leu Ser Arg Gly Pro  Leu Ser Lys Ser Leu  Leu Glu Lys 
    1040                 1045                 1050             


Ala Gly  Pro Glu Leu Gln Glu  Glu Leu Asp Thr Val  Gly Gln Gly 
    1055                 1060                 1065             


Val Ala  Val Ser Met Gly Thr  Val Leu Lys Thr Ser  Ser Trp Asn 
    1070                 1075                 1080             


Leu Asp  Cys Arg Tyr Val Leu  His Val Val Ala Pro  Glu Trp Arg 
    1085                 1090                 1095             


Asn Gly  Ser Thr Ser Ser Leu  Lys Ile Met Glu Asp  Ile Ile Arg 
    1100                 1105                 1110             


Glu Cys  Met Glu Ile Thr Glu  Ser Leu Ser Leu Lys  Ser Ile Ala 
    1115                 1120                 1125             


Phe Pro  Ala Ile Gly Thr Gly  Asn Leu Gly Phe Pro  Lys Asn Ile 
    1130                 1135                 1140             


Phe Ala  Glu Leu Ile Ile Ser  Glu Val Phe Lys Phe  Ser Ser Lys 
    1145                 1150                 1155             


Asn Gln  Leu Lys Thr Leu Gln  Glu Val His Phe Leu  Leu His Pro 
    1160                 1165                 1170             


Ser Asp  His Glu Asn Ile Gln  Ala Phe Ser Asp Glu  Phe Ala Arg 
    1175                 1180                 1185             


Arg Ala  Asn Gly Asn Leu Val  Ser Asp Lys Ile Pro  Lys Ala Lys 
    1190                 1195                 1200             


Asp Thr  Gln Gly Phe Tyr Gly  Thr Val Ser Ser Pro  Asp Ser Gly 
    1205                 1210                 1215             


Val Tyr  Glu Met Lys Ile Gly  Ser Ile Ile Phe Gln  Val Ala Ser 
    1220                 1225                 1230             


Gly Asp  Ile Thr Lys Glu Glu  Ala Asp Val Ile Val  Asn Ser Thr 
    1235                 1240                 1245             


Ser Asn  Ser Phe Asn Leu Lys  Ala Gly Val Ser Lys  Ala Ile Leu 
    1250                 1255                 1260             


Glu Cys  Ala Gly Gln Asn Val  Glu Arg Glu Cys Ser  Gln Gln Ala 
    1265                 1270                 1275             


Gln Gln  Arg Lys Asn Asp Tyr  Ile Ile Thr Gly Gly  Gly Phe Leu 
    1280                 1285                 1290             


Arg Cys  Lys Asn Ile Ile His  Val Ile Gly Gly Asn  Asp Val Lys 
    1295                 1300                 1305             


Ser Ser  Val Ser Ser Val Leu  Gln Glu Cys Glu Lys  Lys Asn Tyr 
    1310                 1315                 1320             


Ser Ser  Ile Cys Leu Pro Ala  Ile Gly Thr Gly Asn  Ala Lys Gln 
    1325                 1330                 1335             


His Pro  Asp Lys Val Ala Glu  Ala Ile Ile Asp Ala  Ile Glu Asp 
    1340                 1345                 1350             


Phe Val  Gln Lys Gly Ser Ala  Gln Ser Val Lys Lys  Val Lys Val 
    1355                 1360                 1365             


Val Ile  Phe Leu Pro Gln Val  Leu Asp Val Phe Tyr  Ala Asn Met 
    1370                 1375                 1380             


Lys Lys  Arg Glu Gly Thr Gln  Leu Ser Ser Gln Gln  Ser Val Met 
    1385                 1390                 1395             


Ser Lys  Leu Ala Ser Phe Leu  Gly Phe Ser Lys Gln  Ser Pro Gln 
    1400                 1405                 1410             


Lys Lys  Asn His Leu Val Leu  Glu Lys Lys Thr Glu  Ser Ala Thr 
    1415                 1420                 1425             


Phe Arg  Val Cys Gly Glu Asn  Val Thr Cys Val Glu  Tyr Ala Ile 
    1430                 1435                 1440             


Ser Trp  Leu Gln Asp Leu Ile  Glu Lys Glu Gln Cys  Pro Tyr Thr 
    1445                 1450                 1455             


Ser Glu  Asp Glu Cys Ile Lys  Asp Phe Asp Glu Lys  Glu Tyr Gln 
    1460                 1465                 1470             


Glu Leu  Asn Glu Leu Gln Lys  Lys Leu Asn Ile Asn  Ile Ser Leu 
    1475                 1480                 1485             


Asp His  Lys Arg Pro Leu Ile  Lys Val Leu Gly Ile  Ser Arg Asp 
    1490                 1495                 1500             


Val Met  Gln Ala Arg Asp Glu  Ile Glu Ala Met Ile  Lys Arg Val 
    1505                 1510                 1515             


Arg Leu  Ala Lys Glu Gln Glu  Ser Arg Ala Asp Cys  Ile Ser Glu 
    1520                 1525                 1530             


Phe Ile  Glu Trp Gln Tyr Asn  Asp Asn Asn Thr Ser  His Cys Phe 
    1535                 1540                 1545             


Asn Lys  Met Thr Asn Leu Lys  Leu Glu Asp Ala Arg  Arg Glu Lys 
    1550                 1555                 1560             


Lys Lys  Thr Val Asp Val Lys  Ile Asn His Arg His  Tyr Thr Val 
    1565                 1570                 1575             


Asn Leu  Asn Thr Tyr Thr Ala  Thr Asp Thr Lys Gly  His Ser Leu 
    1580                 1585                 1590             


Ser Val  Gln Arg Leu Thr Lys  Ser Lys Val Asp Ile  Pro Ala His 
    1595                 1600                 1605             


Trp Ser  Asp Met Lys Gln Gln  Asn Phe Cys Val Val  Glu Leu Leu 
    1610                 1615                 1620             


Pro Ser  Asp Pro Glu Tyr Asn  Thr Val Ala Ser Lys  Phe Asn Gln 
    1625                 1630                 1635             


Thr Cys  Ser His Phe Arg Ile  Glu Lys Ile Glu Arg  Ile Gln Asn 
    1640                 1645                 1650             


Pro Asp  Leu Trp Asn Ser Tyr  Gln Ala Lys Lys Lys  Thr Met Asp 
    1655                 1660                 1665             


Ala Lys  Asn Gly Gln Thr Met  Asn Glu Lys Gln Leu  Phe His Gly 
    1670                 1675                 1680             


Thr Asp  Ala Gly Ser Val Pro  His Val Asn Arg Asn  Gly Phe Asn 
    1685                 1690                 1695             


Arg Ser  Tyr Ala Gly Lys Asn  Ala Val Ala Tyr Gly  Lys Gly Thr 
    1700                 1705                 1710             


Tyr Phe  Ala Val Asn Ala Asn  Tyr Ser Ala Asn Asp  Thr Tyr Ser 
    1715                 1720                 1725             


Arg Pro  Asp Ala Asn Gly Arg  Lys His Val Tyr Tyr  Val Arg Val 
    1730                 1735                 1740             


Leu Thr  Gly Ile Tyr Thr His  Gly Asn His Ser Leu  Ile Val Pro 
    1745                 1750                 1755             


Pro Ser  Lys Asn Pro Gln Asn  Pro Thr Asp Leu Tyr  Asp Thr Val 
    1760                 1765                 1770             


Thr Asp  Asn Val His His Pro  Ser Leu Phe Val Ala  Phe Tyr Asp 
    1775                 1780                 1785             


Tyr Gln  Ala Tyr Pro Glu Tyr  Leu Ile Thr Phe Arg  Lys 
    1790                 1795                 1800     


<210>  38
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210>  39
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Ala Lys Asp Glu Arg Ala Arg Glu Ile Leu Arg Gly Phe Lys 
1               5                   10                  15      


Leu Asn Trp Met Asn Leu Arg Asp Ala Glu Thr Gly Lys Ile Leu Trp 
            20                  25                  30          


Gln Gly Thr Glu Asp Leu Ser Val Pro Gly Val Glu His Glu Ala Arg 
        35                  40                  45              


Val Pro Lys Lys Ile Leu Lys Cys Lys Ala Val Ser Arg Glu Leu Asn 
    50                  55                  60                  


Phe Ser Ser Thr Glu Gln Met Glu Lys Phe Arg Leu Glu Gln Lys Val 
65                  70                  75                  80  


Tyr Phe Lys Gly Gln Cys Leu Glu Glu Trp Phe Phe Glu Phe Gly Phe 
                85                  90                  95      


Val Ile Pro Asn Ser Thr Asn Thr Trp Gln Ser Leu Ile Glu Ala Ala 
            100                 105                 110         


Pro Glu Ser Gln Met Met Pro Ala Ser Val Leu Thr Gly Asn Val Ile 
        115                 120                 125             


Ile Glu Thr Lys Phe Phe Asp Asp Asp Leu Leu Val Ser Thr Ser Arg 
    130                 135                 140                 


Val Arg Leu Phe Tyr Val 
145                 150 


<210>  40
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Phe Gly Leu Lys Arg Asn Ala Val Ile Gly Leu Asn Leu Tyr Cys 
1               5                   10                  15      


Gly Gly Ala Gly Leu Gly Ala Gly Ser Gly Gly Ala Thr Arg Pro Gly 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Glu Lys Glu Ala Ser Ala Arg Arg Glu Ile 
        35                  40                  45              


Gly Gly Gly Glu Ala Gly Ala Val Ile Gly Gly Ser Ala Gly Ala Ser 
    50                  55                  60                  


Pro Pro Ser Thr Leu Thr Pro Asp Ser Arg Arg Val Ala Arg Pro Pro 
65                  70                  75                  80  


Pro Ile Gly Ala Glu Val Pro Asp Val Thr Ala Thr Pro Ala Arg Leu 
                85                  90                  95      


Leu Phe Phe Ala Pro Thr Arg Arg Ala Ala Pro Leu Glu Glu Met Glu 
            100                 105                 110         


Ala Pro Ala Ala Asp Ala Ile Met Ser Pro Glu Glu Glu Leu Asp Gly 
        115                 120                 125             


Tyr Glu Pro Glu Pro Leu Gly Lys Arg Pro Ala Val Leu Pro Leu Leu 
    130                 135                 140                 


Glu Leu Val Gly Glu Ser Gly Asn Asn Thr Ser Thr Asp Gly Ser Leu 
145                 150                 155                 160 


Pro Ser Thr Pro Pro Pro Ala Glu Glu Glu Glu Asp Glu Leu Tyr Arg 
                165                 170                 175     


Gln Ser Leu Glu Ile Ile Ser Arg Tyr Leu Arg Glu Gln Ala Thr Gly 
            180                 185                 190         


Ala Lys Asp Thr Lys Pro Met Gly Arg Ser Gly Ala Thr Ser Arg Lys 
        195                 200                 205             


Ala Leu Glu Thr Leu Arg Arg Val Gly Asp Gly Val Gln Arg Asn His 
    210                 215                 220                 


Glu Thr Ala Phe Gln Gly Met Leu Arg Lys Leu Asp Ile Lys Asn Glu 
225                 230                 235                 240 


Asp Asp Val Lys Ser Leu Ser Arg Val Met Ile His Val Phe Ser Asp 
                245                 250                 255     


Gly Val Thr Asn Trp Gly Arg Ile Val Thr Leu Ile Ser Phe Gly Ala 
            260                 265                 270         


Phe Val Ala Lys His Leu Lys Thr Ile Asn Gln Glu Ser Cys Ile Glu 
        275                 280                 285             


Pro Leu Ala Glu Ser Ile Thr Asp Val Leu Val Arg Thr Lys Arg Asp 
    290                 295                 300                 


Trp Leu Val Lys Gln Arg Gly Trp Asp Gly Phe Val Glu Phe Phe His 
305                 310                 315                 320 


Val Glu Asp Leu Glu Gly Gly Ile Arg Asn Val Leu Leu Ala Phe Ala 
                325                 330                 335     


Gly Val Ala Gly Val Gly Ala Gly Leu Ala Tyr Leu Ile Arg 
            340                 345                 350 


<210>  41
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  42
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Asp Glu Glu Lys Leu Pro Pro Gly Trp Glu Lys Arg Met Ser 
1               5                   10                  15      


Arg Ser Ser Gly Arg Val Tyr Tyr Phe Asn His Ile Thr Asn Ala Ser 
            20                  25                  30          


Gln Trp Glu Arg Pro Ser Gly Asn Ser Ser Ser Gly Gly Lys Asn Gly 
        35                  40                  45              


Gln Gly Glu Pro Ala Arg Val Arg Cys Ser His Leu Leu Val Lys His 
    50                  55                  60                  


Ser Gln Ser Arg Arg Pro Ser Ser Trp Arg Gln Glu Lys Ile Thr Arg 
65                  70                  75                  80  


Thr Lys Glu Glu Ala Leu Glu Leu Ile Asn Gly Tyr Ile Gln Lys Ile 
                85                  90                  95      


Lys Ser Gly Glu Glu Asp Phe Glu Ser Leu Ala Ser Gln Phe Ser Asp 
            100                 105                 110         


Cys Ser Ser Ala Lys Ala Arg Gly Asp Leu Gly Ala Phe Ser Arg Gly 
        115                 120                 125             


Gln Met Gln Lys Pro Phe Glu Asp Ala Ser Phe Ala Leu Arg Thr Gly 
    130                 135                 140                 


Glu Met Ser Gly Pro Val Phe Thr Asp Ser Gly Ile His Ile Ile Leu 
145                 150                 155                 160 


Arg Thr Glu 
            


<210>  43
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Ala Ser Arg Arg Ser Gln His His His His His His Gln Gln 
1               5                   10                  15      


Gln Leu Gln Pro Ala Pro Gly Ala Ser Ala Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Leu Ser Pro Gly Leu Ala Pro Gly Thr Thr Pro Ala Ser Pro 
        35                  40                  45              


Thr Ala Ser Gly Leu Ala Pro Phe Ala Ser Pro Arg His Gly Leu Ala 
    50                  55                  60                  


Leu Pro Glu Gly Asp Gly Ser Arg Asp Pro Pro Asp Arg Pro Arg Ser 
65                  70                  75                  80  


Pro Asp Pro Val Asp Gly Thr Ser Cys Cys Ser Thr Thr Ser Thr Ile 
                85                  90                  95      


Cys Thr Val Ala Ala Ala Pro Val Val Pro Ala Val Ser Thr Ser Ser 
            100                 105                 110         


Ala Ala Gly Val Ala Pro Asn Pro Ala Gly Ser Gly Ser Asn Asn Ser 
        115                 120                 125             


Pro Ser Ser Ser Ser Ser Pro Thr Ser Ser Ser Ser Ser Ser Pro Ser 
    130                 135                 140                 


Ser Pro Gly Ser Ser Leu Ala Glu Ser Pro Glu Ala Ala Gly Val Ser 
145                 150                 155                 160 


Ser Thr Ala Pro Leu Gly Pro Gly Ala Ala Gly Pro Gly Thr Gly Val 
                165                 170                 175     


Pro Ala Val Ser Gly Ala Leu Arg Glu Leu Leu Glu Ala Cys Arg Asn 
            180                 185                 190         


Gly Asp Val Ser Arg Val Lys Arg Leu Val Asp Ala Ala Asn Val Asn 
        195                 200                 205             


Ala Lys Asp Met Ala Gly Arg Lys Ser Ser Pro Leu His Phe Ala Ala 
    210                 215                 220                 


Gly Phe Gly Arg Lys Asp Val Val Glu His Leu Leu Gln Met Gly Ala 
225                 230                 235                 240 


Asn Val His Ala Arg Asp Asp Gly Gly Leu Ile Pro Leu His Asn Ala 
                245                 250                 255     


Cys Ser Phe Gly His Ala Glu Val Val Ser Leu Leu Leu Cys Gln Gly 
            260                 265                 270         


Ala Asp Pro Asn Ala Arg Asp Asn Trp Asn Tyr Thr Pro Leu His Glu 
        275                 280                 285             


Ala Ala Ile Lys Gly Lys Ile Asp Val Cys Ile Val Leu Leu Gln His 
    290                 295                 300                 


Gly Ala Asp Pro Asn Ile Arg Asn Thr Asp Gly Lys Ser Ala Leu Asp 
305                 310                 315                 320 


Leu Ala Asp Pro Ser Ala Lys Ala Val Leu Thr Gly Glu Tyr Lys Lys 
                325                 330                 335     


Asp Glu Leu Leu Glu Ala Ala Arg Ser Gly Asn Glu Glu Lys Leu Met 
            340                 345                 350         


Ala Leu Leu Thr Pro Leu Asn Val Asn Cys His Ala Ser Asp Gly Arg 
        355                 360                 365             


Lys Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn Arg Val Arg Ile 
    370                 375                 380                 


Val Gln Leu Leu Leu Gln His Gly Ala Asp Val His Ala Lys Asp Lys 
385                 390                 395                 400 


Gly Gly Leu Val Pro Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu 
                405                 410                 415     


Val Thr Glu Leu Leu Leu Lys His Gly Ala Cys Val Asn Ala Met Asp 
            420                 425                 430         


Leu Trp Gln Phe Thr Pro Leu His Glu Ala Ala Ser Lys Asn Arg Val 
        435                 440                 445             


Glu Val Cys Ser Leu Leu Leu Ser His Gly Ala Asp Pro Thr Leu Val 
    450                 455                 460                 


Asn Cys His Gly Lys Ser Ala Val Asp Met Ala Pro Thr Pro Glu Leu 
465                 470                 475                 480 


Arg Glu Arg Leu Thr Tyr Glu Phe Lys Gly His Ser Leu Leu Gln Ala 
                485                 490                 495     


Ala Arg Glu Ala Asp Leu Ala Lys Val Lys Lys Thr Leu Ala Leu Glu 
            500                 505                 510         


Ile Ile Asn Phe Lys Gln Pro Gln Ser His Glu Thr Ala Leu His Cys 
        515                 520                 525             


Ala Val Ala Ser Leu His Pro Lys Arg Lys Gln Val Thr Glu Leu Leu 
    530                 535                 540                 


Leu Arg Lys Gly Ala Asn Val Asn Glu Lys Asn Lys Asp Phe Met Thr 
545                 550                 555                 560 


Pro Leu His Val Ala Ala Glu Arg Ala His Asn Asp Val Met Glu Val 
                565                 570                 575     


Leu His Lys His Gly Ala Lys Met Asn Ala Leu Asp Thr Leu Gly Gln 
            580                 585                 590         


Thr Ala Leu His Arg Ala Ala Leu Ala Gly His Leu Gln Thr Cys Arg 
        595                 600                 605             


Leu Leu Leu Ser Tyr Gly Ser Asp Pro Ser Ile Ile Ser Leu Gln Gly 
    610                 615                 620                 


Phe Thr Ala Ala Gln Met Gly Asn Glu Ala Val Gln Gln Ile Leu Ser 
625                 630                 635                 640 


Glu Ser Thr Pro Ile Arg Thr Ser Asp Val Asp Tyr Arg Leu Leu Glu 
                645                 650                 655     


Ala Ser Lys Ala Gly Asp Leu Glu Thr Val Lys Gln Leu Cys Ser Ser 
            660                 665                 670         


Gln Asn Val Asn Cys Arg Asp Leu Glu Gly Arg His Ser Thr Pro Leu 
        675                 680                 685             


His Phe Ala Ala Gly Tyr Asn Arg Val Ser Val Val Glu Tyr Leu Leu 
    690                 695                 700                 


His His Gly Ala Asp Val His Ala Lys Asp Lys Gly Gly Leu Val Pro 
705                 710                 715                 720 


Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu Val Ala Glu Leu Leu 
                725                 730                 735     


Val Arg His Gly Ala Ser Val Asn Val Ala Asp Leu Trp Lys Phe Thr 
            740                 745                 750         


Pro Leu His Glu Ala Ala Ala Lys Gly Lys Tyr Glu Ile Cys Lys Leu 
        755                 760                 765             


Leu Leu Lys His Gly Ala Asp Pro Thr Lys Lys Asn Arg Asp Gly Asn 
    770                 775                 780                 


Thr Pro Leu Asp Leu Val Lys Glu Gly Asp Thr Asp Ile Gln Asp Leu 
785                 790                 795                 800 


Leu Arg Gly Asp Ala Ala Leu Leu Asp Ala Ala Lys Lys Gly Cys Leu 
                805                 810                 815     


Ala Arg Val Gln Lys Leu Cys Thr Pro Glu Asn Ile Asn Cys Arg Asp 
            820                 825                 830         


Thr Gln Gly Arg Asn Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn 
        835                 840                 845             


Asn Leu Glu Val Ala Glu Tyr Leu Leu Glu His Gly Ala Asp Val Asn 
    850                 855                 860                 


Ala Gln Asp Lys Gly Gly Leu Ile Pro Leu His Asn Ala Ala Ser Tyr 
865                 870                 875                 880 


Gly His Val Asp Ile Ala Ala Leu Leu Ile Lys Tyr Asn Thr Cys Val 
                885                 890                 895     


Asn Ala Thr Asp Lys Trp Ala Phe Thr Pro Leu His Glu Ala Ala Gln 
            900                 905                 910         


Lys Gly Arg Thr Gln Leu Cys Ala Leu Leu Leu Ala His Gly Ala Asp 
        915                 920                 925             


Pro Thr Met Lys Asn Gln Glu Gly Gln Thr Pro Leu Asp Leu Ala Thr 
    930                 935                 940                 


Ala Asp Asp Ile Arg Ala Leu Leu Ile Asp Ala Met Pro Pro Glu Ala 
945                 950                 955                 960 


Leu Pro Thr Cys Phe Lys Pro Gln Ala Thr Val Val Ser Ala Ser Leu 
                965                 970                 975     


Ile Ser Pro Ala Ser Thr Pro Ser Cys Leu Ser Ala Ala Ser Ser Ile 
            980                 985                 990         


Asp Asn Leu Thr Gly Pro Leu Ala  Glu Leu Ala Val Gly  Gly Ala Ser 
        995                 1000                 1005             


Asn Ala  Gly Asp Gly Ala Ala  Gly Thr Glu Arg Lys  Glu Gly Glu 
    1010                 1015                 1020             


Val Ala  Gly Leu Asp Met Asn  Ile Ser Gln Phe Leu  Lys Ser Leu 
    1025                 1030                 1035             


Gly Leu  Glu His Leu Arg Asp  Ile Phe Glu Thr Glu  Gln Ile Thr 
    1040                 1045                 1050             


Leu Asp  Val Leu Ala Asp Met  Gly His Glu Glu Leu  Lys Glu Ile 
    1055                 1060                 1065             


Gly Ile  Asn Ala Tyr Gly His  Arg His Lys Leu Ile  Lys Gly Val 
    1070                 1075                 1080             


Glu Arg  Leu Leu Gly Gly Gln  Gln Gly Thr Asn Pro  Tyr Leu Thr 
    1085                 1090                 1095             


Phe His  Cys Val Asn Gln Gly  Thr Ile Leu Leu Asp  Leu Ala Pro 
    1100                 1105                 1110             


Glu Asp  Lys Glu Tyr Gln Ser  Val Glu Glu Glu Met  Gln Ser Thr 
    1115                 1120                 1125             


Ile Arg  Glu His Arg Asp Gly  Gly Asn Ala Gly Gly  Ile Phe Asn 
    1130                 1135                 1140             


Arg Tyr  Asn Val Ile Arg Ile  Gln Lys Val Val Asn  Lys Lys Leu 
    1145                 1150                 1155             


Arg Glu  Arg Phe Cys His Arg  Gln Lys Glu Val Ser  Glu Glu Asn 
    1160                 1165                 1170             


His Asn  His His Asn Glu Arg  Met Leu Phe His Gly  Ser Pro Phe 
    1175                 1180                 1185             


Ile Asn  Ala Ile Ile His Lys  Gly Phe Asp Glu Arg  His Ala Tyr 
    1190                 1195                 1200             


Ile Gly  Gly Met Phe Gly Ala  Gly Ile Tyr Phe Ala  Glu Asn Ser 
    1205                 1210                 1215             


Ser Lys  Ser Asn Gln Tyr Val  Tyr Gly Ile Gly Gly  Gly Thr Gly 
    1220                 1225                 1230             


Cys Pro  Thr His Lys Asp Arg  Ser Cys Tyr Ile Cys  His Arg Gln 
    1235                 1240                 1245             


Met Leu  Phe Cys Arg Val Thr  Leu Gly Lys Ser Phe  Leu Gln Phe 
    1250                 1255                 1260             


Ser Thr  Met Lys Met Ala His  Ala Pro Pro Gly His  His Ser Val 
    1265                 1270                 1275             


Ile Gly  Arg Pro Ser Val Asn  Gly Leu Ala Tyr Ala  Glu Tyr Val 
    1280                 1285                 1290             


Ile Tyr  Arg Gly Glu Gln Ala  Tyr Pro Glu Tyr Leu  Ile Thr Tyr 
    1295                 1300                 1305             


Gln Ile  Met Lys Pro Glu Ala  Pro Ser Gln Thr Ala  Thr Ala Ala 
    1310                 1315                 1320             


Glu Gln  Lys Thr 
    1325         


<210>  44
<211>  1166
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Gly Arg Arg Cys Ala Gly Gly Gly Ala Ala Cys Ala Ser Ala 
1               5                   10                  15      


Ala Ala Glu Ala Val Glu Pro Ala Ala Arg Glu Leu Phe Glu Ala Cys 
            20                  25                  30          


Arg Asn Gly Asp Val Glu Arg Val Lys Arg Leu Val Thr Pro Glu Lys 
        35                  40                  45              


Val Asn Ser Arg Asp Thr Ala Gly Arg Lys Ser Thr Pro Leu His Phe 
    50                  55                  60                  


Ala Ala Gly Phe Gly Arg Lys Asp Val Val Glu Tyr Leu Leu Gln Asn 
65                  70                  75                  80  


Gly Ala Asn Val Gln Ala Arg Asp Asp Gly Gly Leu Ile Pro Leu His 
                85                  90                  95      


Asn Ala Cys Ser Phe Gly His Ala Glu Val Val Asn Leu Leu Leu Arg 
            100                 105                 110         


His Gly Ala Asp Pro Asn Ala Arg Asp Asn Trp Asn Tyr Thr Pro Leu 
        115                 120                 125             


His Glu Ala Ala Ile Lys Gly Lys Ile Asp Val Cys Ile Val Leu Leu 
    130                 135                 140                 


Gln His Gly Ala Glu Pro Thr Ile Arg Asn Thr Asp Gly Arg Thr Ala 
145                 150                 155                 160 


Leu Asp Leu Ala Asp Pro Ser Ala Lys Ala Val Leu Thr Gly Glu Tyr 
                165                 170                 175     


Lys Lys Asp Glu Leu Leu Glu Ser Ala Arg Ser Gly Asn Glu Glu Lys 
            180                 185                 190         


Met Met Ala Leu Leu Thr Pro Leu Asn Val Asn Cys His Ala Ser Asp 
        195                 200                 205             


Gly Arg Lys Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn Arg Val 
    210                 215                 220                 


Lys Ile Val Gln Leu Leu Leu Gln His Gly Ala Asp Val His Ala Lys 
225                 230                 235                 240 


Asp Lys Gly Asp Leu Val Pro Leu His Asn Ala Cys Ser Tyr Gly His 
                245                 250                 255     


Tyr Glu Val Thr Glu Leu Leu Val Lys His Gly Ala Cys Val Asn Ala 
            260                 265                 270         


Met Asp Leu Trp Gln Phe Thr Pro Leu His Glu Ala Ala Ser Lys Asn 
        275                 280                 285             


Arg Val Glu Val Cys Ser Leu Leu Leu Ser Tyr Gly Ala Asp Pro Thr 
    290                 295                 300                 


Leu Leu Asn Cys His Asn Lys Ser Ala Ile Asp Leu Ala Pro Thr Pro 
305                 310                 315                 320 


Gln Leu Lys Glu Arg Leu Ala Tyr Glu Phe Lys Gly His Ser Leu Leu 
                325                 330                 335     


Gln Ala Ala Arg Glu Ala Asp Val Thr Arg Ile Lys Lys His Leu Ser 
            340                 345                 350         


Leu Glu Met Val Asn Phe Lys His Pro Gln Thr His Glu Thr Ala Leu 
        355                 360                 365             


His Cys Ala Ala Ala Ser Pro Tyr Pro Lys Arg Lys Gln Ile Cys Glu 
    370                 375                 380                 


Leu Leu Leu Arg Lys Gly Ala Asn Ile Asn Glu Lys Thr Lys Glu Phe 
385                 390                 395                 400 


Leu Thr Pro Leu His Val Ala Ser Glu Lys Ala His Asn Asp Val Val 
                405                 410                 415     


Glu Val Val Val Lys His Glu Ala Lys Val Asn Ala Leu Asp Asn Leu 
            420                 425                 430         


Gly Gln Thr Ser Leu His Arg Ala Ala Tyr Cys Gly His Leu Gln Thr 
        435                 440                 445             


Cys Arg Leu Leu Leu Ser Tyr Gly Cys Asp Pro Asn Ile Ile Ser Leu 
    450                 455                 460                 


Gln Gly Phe Thr Ala Leu Gln Met Gly Asn Glu Asn Val Gln Gln Leu 
465                 470                 475                 480 


Leu Gln Glu Gly Ile Ser Leu Gly Asn Ser Glu Ala Asp Arg Gln Leu 
                485                 490                 495     


Leu Glu Ala Ala Lys Ala Gly Asp Val Glu Thr Val Lys Lys Leu Cys 
            500                 505                 510         


Thr Val Gln Ser Val Asn Cys Arg Asp Ile Glu Gly Arg Gln Ser Thr 
        515                 520                 525             


Pro Leu His Phe Ala Ala Gly Tyr Asn Arg Val Ser Val Val Glu Tyr 
    530                 535                 540                 


Leu Leu Gln His Gly Ala Asp Val His Ala Lys Asp Lys Gly Gly Leu 
545                 550                 555                 560 


Val Pro Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu Val Ala Glu 
                565                 570                 575     


Leu Leu Val Lys His Gly Ala Val Val Asn Val Ala Asp Leu Trp Lys 
            580                 585                 590         


Phe Thr Pro Leu His Glu Ala Ala Ala Lys Gly Lys Tyr Glu Ile Cys 
        595                 600                 605             


Lys Leu Leu Leu Gln His Gly Ala Asp Pro Thr Lys Lys Asn Arg Asp 
    610                 615                 620                 


Gly Asn Thr Pro Leu Asp Leu Val Lys Asp Gly Asp Thr Asp Ile Gln 
625                 630                 635                 640 


Asp Leu Leu Arg Gly Asp Ala Ala Leu Leu Asp Ala Ala Lys Lys Gly 
                645                 650                 655     


Cys Leu Ala Arg Val Lys Lys Leu Ser Ser Pro Asp Asn Val Asn Cys 
            660                 665                 670         


Arg Asp Thr Gln Gly Arg His Ser Thr Pro Leu His Leu Ala Ala Gly 
        675                 680                 685             


Tyr Asn Asn Leu Glu Val Ala Glu Tyr Leu Leu Gln His Gly Ala Asp 
    690                 695                 700                 


Val Asn Ala Gln Asp Lys Gly Gly Leu Ile Pro Leu His Asn Ala Ala 
705                 710                 715                 720 


Ser Tyr Gly His Val Asp Val Ala Ala Leu Leu Ile Lys Tyr Asn Ala 
                725                 730                 735     


Cys Val Asn Ala Thr Asp Lys Trp Ala Phe Thr Pro Leu His Glu Ala 
            740                 745                 750         


Ala Gln Lys Gly Arg Thr Gln Leu Cys Ala Leu Leu Leu Ala His Gly 
        755                 760                 765             


Ala Asp Pro Thr Leu Lys Asn Gln Glu Gly Gln Thr Pro Leu Asp Leu 
    770                 775                 780                 


Val Ser Ala Asp Asp Val Ser Ala Leu Leu Thr Ala Ala Met Pro Pro 
785                 790                 795                 800 


Ser Ala Leu Pro Ser Cys Tyr Lys Pro Gln Val Leu Asn Gly Val Arg 
                805                 810                 815     


Ser Pro Gly Ala Thr Ala Asp Ala Leu Ser Ser Gly Pro Ser Ser Pro 
            820                 825                 830         


Ser Ser Leu Ser Ala Ala Ser Ser Leu Asp Asn Leu Ser Gly Ser Phe 
        835                 840                 845             


Ser Glu Leu Ser Ser Val Val Ser Ser Ser Gly Thr Glu Gly Ala Ser 
    850                 855                 860                 


Ser Leu Glu Lys Lys Glu Val Pro Gly Val Asp Phe Ser Ile Thr Gln 
865                 870                 875                 880 


Phe Val Arg Asn Leu Gly Leu Glu His Leu Met Asp Ile Phe Glu Arg 
                885                 890                 895     


Glu Gln Ile Thr Leu Asp Val Leu Val Glu Met Gly His Lys Glu Leu 
            900                 905                 910         


Lys Glu Ile Gly Ile Asn Ala Tyr Gly His Arg His Lys Leu Ile Lys 
        915                 920                 925             


Gly Val Glu Arg Leu Ile Ser Gly Gln Gln Gly Leu Asn Pro Tyr Leu 
    930                 935                 940                 


Thr Leu Asn Thr Ser Gly Ser Gly Thr Ile Leu Ile Asp Leu Ser Pro 
945                 950                 955                 960 


Asp Asp Lys Glu Phe Gln Ser Val Glu Glu Glu Met Gln Ser Thr Val 
                965                 970                 975     


Arg Glu His Arg Asp Gly Gly His Ala Gly Gly Ile Phe Asn Arg Tyr 
            980                 985                 990         


Asn Ile Leu Lys Ile Gln Lys Val  Cys Asn Lys Lys Leu  Trp Glu Arg 
        995                 1000                 1005             


Tyr Thr  His Arg Arg Lys Glu  Val Ser Glu Glu Asn  His Asn His 
    1010                 1015                 1020             


Ala Asn  Glu Arg Met Leu Phe  His Gly Ser Pro Phe  Val Asn Ala 
    1025                 1030                 1035             


Ile Ile  His Lys Gly Phe Asp  Glu Arg His Ala Tyr  Ile Gly Gly 
    1040                 1045                 1050             


Met Phe  Gly Ala Gly Ile Tyr  Phe Ala Glu Asn Ser  Ser Lys Ser 
    1055                 1060                 1065             


Asn Gln  Tyr Val Tyr Gly Ile  Gly Gly Gly Thr Gly  Cys Pro Val 
    1070                 1075                 1080             


His Lys  Asp Arg Ser Cys Tyr  Ile Cys His Arg Gln  Leu Leu Phe 
    1085                 1090                 1095             


Cys Arg  Val Thr Leu Gly Lys  Ser Phe Leu Gln Phe  Ser Ala Met 
    1100                 1105                 1110             


Lys Met  Ala His Ser Pro Pro  Gly His His Ser Val  Thr Gly Arg 
    1115                 1120                 1125             


Pro Ser  Val Asn Gly Leu Ala  Leu Ala Glu Tyr Val  Ile Tyr Arg 
    1130                 1135                 1140             


Gly Glu  Gln Ala Tyr Pro Glu  Tyr Leu Ile Thr Tyr  Gln Ile Met 
    1145                 1150                 1155             


Arg Pro  Glu Gly Met Val Asp  Gly 
    1160                 1165     


<210>  45
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Tyr Trp Ser Asn Gln Ile Thr Arg Arg Leu Gly Glu Arg Val Gln 
1               5                   10                  15      


Gly Phe Met Ser Gly Ile Ser Pro Gln Gln Met Gly Glu Pro Glu Gly 
            20                  25                  30          


Ser Trp Ser Gly Lys Asn Pro Gly Thr Met Gly Ala Ser Arg Leu Tyr 
        35                  40                  45              


Thr Leu Val Leu Val Leu Gln Pro Gln Arg Val Leu Leu Gly Met Lys 
    50                  55                  60                  


Lys Arg Gly Phe Gly Ala Gly Arg Trp Asn Gly Phe Gly Gly Lys Val 
65                  70                  75                  80  


Gln Glu Gly Glu Thr Ile Glu Asp Gly Ala Arg Arg Glu Leu Gln Glu 
                85                  90                  95      


Glu Ser Gly Leu Thr Val Asp Ala Leu His Lys Val Gly Gln Ile Val 
            100                 105                 110         


Phe Glu Phe Val Gly Glu Pro Glu Leu Met Asp Val His Val Phe Cys 
        115                 120                 125             


Thr Asp Ser Ile Gln Gly Thr Pro Val Glu Ser Asp Glu Met Arg Pro 
    130                 135                 140                 


Cys Trp Phe Gln Leu Asp Gln Ile Pro Phe Lys Asp Met Trp Pro Asp 
145                 150                 155                 160 


Asp Ser Tyr Trp Phe Pro Leu Leu Leu Gln Lys Lys Lys Phe His Gly 
                165                 170                 175     


Tyr Phe Lys Phe Gln Gly Gln Asp Thr Ile Leu Asp Tyr Thr Leu Arg 
            180                 185                 190         


Glu Val Asp Thr Val 
        195         


<210>  46
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  47
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Ala His Ser Leu Val Met Ser Ser Pro Ala Leu Pro Ala Phe 
1               5                   10                  15      


Leu Leu Cys Ser Thr Leu Leu Val Ile Lys Met Tyr Val Val Ala Ile 
            20                  25                  30          


Ile Thr Gly Gln Val Arg Leu Arg Lys Lys Ala Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Ala Leu Arg His Gly Gly Pro Gln Tyr Cys Arg Ser Asp Pro Asp 
    50                  55                  60                  


Val Glu Arg Cys Leu Arg Ala His Arg Asn Asp Met Glu Thr Ile Tyr 
65                  70                  75                  80  


Pro Phe Leu Phe Leu Gly Phe Val Tyr Ser Phe Leu Gly Pro Asn Pro 
                85                  90                  95      


Phe Val Ala Trp Met His Phe Leu Val Phe Leu Val Gly Arg Val Ala 
            100                 105                 110         


His Thr Val Ala Tyr Leu Gly Lys Leu Arg Ala Pro Ile Arg Ser Val 
        115                 120                 125             


Thr Tyr Thr Leu Ala Gln Leu Pro Cys Ala Ser Met Ala Leu Gln Ile 
    130                 135                 140                 


Leu Trp Glu Ala Ala Arg His Leu 
145                 150         


<210>  48
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asp Gln Glu Thr Val Gly Asn Val Val Leu Leu Ala Ile Val Thr 
1               5                   10                  15      


Leu Ile Ser Val Val Gln Asn Gly Phe Phe Ala His Lys Val Glu His 
            20                  25                  30          


Glu Ser Arg Thr Gln Asn Gly Arg Ser Phe Gln Arg Thr Gly Thr Leu 
        35                  40                  45              


Ala Phe Glu Arg Val Tyr Thr Ala Asn Gln Asn Cys Val Asp Ala Tyr 
    50                  55                  60                  


Pro Thr Phe Leu Ala Val Leu Trp Ser Ala Gly Leu Leu Cys Ser Gln 
65                  70                  75                  80  


Val Pro Ala Ala Phe Ala Gly Leu Met Tyr Leu Phe Val Arg Gln Lys 
                85                  90                  95      


Tyr Phe Val Gly Tyr Leu Gly Glu Arg Thr Gln Ser Thr Pro Gly Tyr 
            100                 105                 110         


Ile Phe Gly Lys Arg Ile Ile Leu Phe Leu Phe Leu Met Ser Val Ala 
        115                 120                 125             


Gly Ile Phe Asn Tyr Tyr Leu Ile Phe Phe Phe Gly Ser Asp Phe Glu 
    130                 135                 140                 


Asn Tyr Ile Lys Thr Ile Ser Thr Thr Ile Ser Pro Leu Leu Leu Ile 
145                 150                 155                 160 


Pro 
    


<210>  49
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Cys Asp Ala Phe Val Gly Thr Trp Lys Leu Val Ser Ser Glu Asn 
1               5                   10                  15      


Phe Asp Asp Tyr Met Lys Glu Val Gly Val Gly Phe Ala Thr Arg Lys 
            20                  25                  30          


Val Ala Gly Met Ala Lys Pro Asn Met Ile Ile Ser Val Asn Gly Asp 
        35                  40                  45              


Val Ile Thr Ile Lys Ser Glu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Ile Leu Gly Gln Glu Phe Asp Glu Val Thr Ala Asp Asp Arg Lys 
65                  70                  75                  80  


Val Lys Ser Thr Ile Thr Leu Asp Gly Gly Val Leu Val His Val Gln 
                85                  90                  95      


Lys Trp Asp Gly Lys Ser Thr Thr Ile Lys Arg Lys Arg Glu Asp Asp 
            100                 105                 110         


Lys Leu Val Val Glu Cys Val Met Lys Gly Val Thr Ser Thr Arg Val 
        115                 120                 125             


Tyr Glu Arg Ala 
    130         


<210>  50
<211>  1821
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Cys Glu Arg Lys Gly Leu Ser Glu Leu Arg Ser Glu Leu Tyr 
1               5                   10                  15      


Phe Leu Ile Ala Arg Phe Leu Glu Asp Gly Pro Cys Gln Gln Ala Ala 
            20                  25                  30          


Gln Val Leu Ile Arg Glu Val Ala Glu Lys Glu Leu Leu Pro Arg Arg 
        35                  40                  45              


Thr Asp Trp Thr Gly Lys Glu His Pro Arg Thr Tyr Gln Asn Leu Val 
    50                  55                  60                  


Lys Tyr Tyr Arg His Leu Ala Pro Asp His Leu Leu Gln Ile Cys His 
65                  70                  75                  80  


Arg Leu Gly Pro Leu Leu Glu Gln Glu Ile Pro Gln Ser Val Pro Gly 
                85                  90                  95      


Val Gln Thr Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu Arg Thr Asn 
            100                 105                 110         


Lys Ser Cys Lys His Val Val Trp Lys Gly Ser Ala Leu Ala Ala Leu 
        115                 120                 125             


His Cys Gly Arg Pro Pro Glu Ser Pro Val Asn Tyr Gly Ser Pro Pro 
    130                 135                 140                 


Ser Ile Ala Asp Thr Leu Phe Ser Arg Lys Leu Asn Gly Lys Tyr Arg 
145                 150                 155                 160 


Leu Glu Arg Leu Val Pro Thr Ala Val Tyr Gln His Met Lys Met His 
                165                 170                 175     


Lys Arg Ile Leu Gly His Leu Ser Ser Val Tyr Cys Val Thr Phe Asp 
            180                 185                 190         


Arg Thr Gly Arg Arg Ile Phe Thr Gly Ser Asp Asp Cys Leu Val Lys 
        195                 200                 205             


Ile Trp Ala Thr Asp Asp Gly Arg Leu Leu Ala Thr Leu Arg Gly His 
    210                 215                 220                 


Ala Ala Glu Ile Ser Asp Met Ala Val Asn Tyr Glu Asn Thr Met Ile 
225                 230                 235                 240 


Ala Ala Gly Ser Cys Asp Lys Met Ile Arg Val Trp Cys Leu Arg Thr 
                245                 250                 255     


Cys Ala Pro Leu Ala Val Leu Gln Gly His Ser Ala Ser Ile Thr Ser 
            260                 265                 270         


Leu Gln Phe Ser Pro Leu Cys Ser Gly Ser Lys Arg Tyr Leu Ser Ser 
        275                 280                 285             


Thr Gly Ala Asp Gly Thr Ile Cys Phe Trp Leu Trp Asp Ala Gly Thr 
    290                 295                 300                 


Leu Lys Ile Asn Pro Arg Pro Ala Lys Phe Thr Glu Arg Pro Arg Pro 
305                 310                 315                 320 


Gly Val Gln Met Ile Cys Ser Ser Phe Ser Ala Gly Gly Met Phe Leu 
                325                 330                 335     


Ala Thr Gly Ser Thr Asp His Ile Ile Arg Val Tyr Phe Phe Gly Ser 
            340                 345                 350         


Gly Gln Pro Glu Lys Ile Ser Glu Leu Glu Phe His Thr Asp Lys Val 
        355                 360                 365             


Asp Ser Ile Gln Phe Ser Asn Thr Ser Asn Arg Phe Val Ser Gly Ser 
    370                 375                 380                 


Arg Asp Gly Thr Ala Arg Ile Trp Gln Phe Lys Arg Arg Glu Trp Lys 
385                 390                 395                 400 


Ser Ile Leu Leu Asp Met Ala Thr Arg Pro Ala Gly Gln Asn Leu Gln 
                405                 410                 415     


Gly Ile Glu Asp Lys Ile Thr Lys Met Lys Val Thr Met Val Ala Trp 
            420                 425                 430         


Asp Arg His Asp Asn Thr Val Ile Thr Ala Val Asn Asn Met Thr Leu 
        435                 440                 445             


Lys Val Trp Asn Ser Tyr Thr Gly Gln Leu Ile His Val Leu Met Gly 
    450                 455                 460                 


His Glu Asp Glu Val Phe Val Leu Glu Pro His Pro Phe Asp Pro Arg 
465                 470                 475                 480 


Val Leu Phe Ser Ala Gly His Asp Gly Asn Val Ile Val Trp Asp Leu 
                485                 490                 495     


Ala Arg Gly Val Lys Ile Arg Ser Tyr Phe Asn Met Ile Glu Gly Gln 
            500                 505                 510         


Gly His Gly Ala Val Phe Asp Cys Lys Cys Ser Pro Asp Gly Gln His 
        515                 520                 525             


Phe Ala Cys Thr Asp Ser His Gly His Leu Leu Ile Phe Gly Phe Gly 
    530                 535                 540                 


Ser Ser Ser Lys Tyr Asp Lys Ile Ala Asp Gln Met Phe Phe His Ser 
545                 550                 555                 560 


Asp Tyr Arg Pro Leu Ile Arg Asp Ala Asn Asn Phe Val Leu Asp Glu 
                565                 570                 575     


Gln Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu Val Asp 
            580                 585                 590         


Val Asp Gly Asn Pro His Pro Ser Arg Tyr Gln Arg Leu Val Pro Gly 
        595                 600                 605             


Arg Glu Asn Cys Arg Glu Glu Gln Leu Ile Pro Gln Met Gly Val Thr 
    610                 615                 620                 


Ser Ser Gly Leu Asn Gln Val Leu Ser Gln Gln Ala Asn Gln Glu Ile 
625                 630                 635                 640 


Ser Pro Leu Asp Ser Met Ile Gln Arg Leu Gln Gln Glu Gln Asp Leu 
                645                 650                 655     


Arg Arg Ser Gly Glu Ala Val Ile Ser Asn Thr Ser Arg Leu Ser Arg 
            660                 665                 670         


Gly Ser Ile Ser Ser Thr Ser Glu Val His Ser Pro Pro Asn Val Gly 
        675                 680                 685             


Leu Arg Arg Ser Gly Gln Ile Glu Gly Val Arg Gln Met His Ser Asn 
    690                 695                 700                 


Ala Pro Arg Ser Glu Ile Ala Thr Glu Arg Asp Leu Val Ala Trp Ser 
705                 710                 715                 720 


Arg Arg Val Val Val Pro Glu Leu Ser Ala Gly Val Ala Ser Arg Gln 
                725                 730                 735     


Glu Glu Trp Arg Thr Ala Lys Gly Glu Glu Glu Ile Lys Thr Tyr Arg 
            740                 745                 750         


Ser Glu Glu Lys Arg Lys His Leu Thr Val Pro Lys Glu Asn Lys Ile 
        755                 760                 765             


Pro Thr Val Ser Lys Asn His Ala His Glu His Phe Leu Asp Leu Gly 
    770                 775                 780                 


Glu Ser Lys Lys Gln Gln Thr Asn Gln His Asn Tyr Arg Thr Arg Ser 
785                 790                 795                 800 


Ala Leu Glu Glu Thr Pro Arg Pro Ser Glu Glu Ile Glu Asn Gly Ser 
                805                 810                 815     


Ser Ser Ser Asp Glu Gly Glu Val Val Ala Val Ser Gly Gly Thr Ser 
            820                 825                 830         


Glu Glu Glu Glu Arg Ala Trp His Ser Asp Gly Ser Ser Ser Asp Tyr 
        835                 840                 845             


Ser Ser Asp Tyr Ser Asp Trp Thr Ala Asp Ala Gly Ile Asn Leu Gln 
    850                 855                 860                 


Pro Pro Lys Lys Val Pro Lys Asn Lys Thr Lys Lys Ala Glu Ser Ser 
865                 870                 875                 880 


Ser Asp Glu Glu Glu Glu Ser Glu Lys Gln Lys Gln Lys Gln Ile Lys 
                885                 890                 895     


Lys Glu Lys Lys Lys Val Asn Glu Glu Lys Asp Gly Pro Ile Ser Pro 
            900                 905                 910         


Lys Lys Lys Lys Pro Lys Glu Arg Lys Gln Lys Arg Leu Ala Val Gly 
        915                 920                 925             


Glu Leu Thr Glu Asn Gly Leu Thr Leu Glu Glu Trp Leu Pro Ser Thr 
    930                 935                 940                 


Trp Ile Thr Asp Thr Ile Pro Arg Arg Cys Pro Phe Val Pro Gln Met 
945                 950                 955                 960 


Gly Asp Glu Val Tyr Tyr Phe Arg Gln Gly His Glu Ala Tyr Val Glu 
                965                 970                 975     


Met Ala Arg Lys Asn Lys Ile Tyr Ser Ile Asn Pro Lys Lys Gln Pro 
            980                 985                 990         


Trp His Lys Met Glu Leu Arg Glu  Gln Glu Leu Met Lys  Ile Val Gly 
        995                 1000                 1005             


Ile Lys  Tyr Glu Val Gly Leu  Pro Thr Leu Cys Cys  Leu Lys Leu 
    1010                 1015                 1020             


Ala Phe  Leu Asp Pro Asp Thr  Gly Lys Leu Thr Gly  Gly Ser Phe 
    1025                 1030                 1035             


Thr Met  Lys Tyr His Asp Met  Pro Asp Val Ile Asp  Phe Leu Val 
    1040                 1045                 1050             


Leu Arg  Gln Gln Phe Asp Asp  Ala Lys Tyr Arg Arg  Trp Asn Ile 
    1055                 1060                 1065             


Gly Asp  Arg Phe Arg Ser Val  Ile Asp Asp Ala Trp  Trp Phe Gly 
    1070                 1075                 1080             


Thr Ile  Glu Ser Gln Glu Pro  Leu Gln Leu Glu Tyr  Pro Asp Ser 
    1085                 1090                 1095             


Leu Phe  Gln Cys Tyr Asn Val  Cys Trp Asp Asn Gly  Asp Thr Glu 
    1100                 1105                 1110             


Lys Met  Ser Pro Trp Asp Met  Glu Leu Ile Pro Asn  Asn Ala Val 
    1115                 1120                 1125             


Phe Pro  Glu Glu Leu Gly Thr  Ser Val Pro Leu Thr  Asp Gly Glu 
    1130                 1135                 1140             


Cys Arg  Ser Leu Ile Tyr Lys  Pro Leu Asp Gly Glu  Trp Gly Thr 
    1145                 1150                 1155             


Asn Pro  Arg Asp Glu Glu Cys  Glu Arg Ile Val Ala  Gly Ile Asn 
    1160                 1165                 1170             


Gln Leu  Met Thr Leu Asp Ile  Ala Ser Ala Phe Val  Ala Pro Val 
    1175                 1180                 1185             


Asp Leu  Gln Ala Tyr Pro Met  Tyr Cys Thr Val Val  Ala Tyr Pro 
    1190                 1195                 1200             


Thr Asp  Leu Ser Thr Ile Lys  Gln Arg Leu Glu Asn  Arg Phe Tyr 
    1205                 1210                 1215             


Arg Arg  Val Ser Ser Leu Met  Trp Glu Val Arg Tyr  Ile Glu His 
    1220                 1225                 1230             


Asn Thr  Arg Thr Phe Asn Glu  Pro Gly Ser Pro Ile  Val Lys Ser 
    1235                 1240                 1245             


Ala Lys  Phe Val Thr Asp Leu  Leu Leu His Phe Ile  Lys Asp Gln 
    1250                 1255                 1260             


Thr Cys  Tyr Asn Ile Ile Pro  Leu Tyr Asn Ser Met  Lys Lys Lys 
    1265                 1270                 1275             


Val Leu  Ser Asp Ser Glu Asp  Glu Glu Lys Asp Ala  Asp Val Pro 
    1280                 1285                 1290             


Gly Thr  Ser Thr Arg Lys Arg  Lys Asp His Gln Pro  Arg Arg Arg 
    1295                 1300                 1305             


Leu Arg  Asn Arg Ala Gln Ser  Tyr Asp Ile Gln Ala  Trp Lys Lys 
    1310                 1315                 1320             


Gln Cys  Glu Glu Leu Leu Asn  Leu Ile Phe Gln Cys  Glu Asp Ser 
    1325                 1330                 1335             


Glu Pro  Phe Arg Gln Pro Val  Asp Leu Leu Glu Tyr  Pro Asp Tyr 
    1340                 1345                 1350             


Arg Asp  Ile Ile Asp Thr Pro  Met Asp Phe Ala Thr  Val Arg Glu 
    1355                 1360                 1365             


Thr Leu  Glu Ala Gly Asn Tyr  Glu Ser Pro Met Glu  Leu Cys Lys 
    1370                 1375                 1380             


Asp Val  Arg Leu Ile Phe Ser  Asn Ser Lys Ala Tyr  Thr Pro Ser 
    1385                 1390                 1395             


Lys Arg  Ser Arg Ile Tyr Ser  Met Ser Leu Arg Leu  Ser Ala Phe 
    1400                 1405                 1410             


Phe Glu  Glu His Ile Ser Ser  Val Leu Ser Asp Tyr  Lys Ser Ala 
    1415                 1420                 1425             


Leu Arg  Phe His Lys Arg Asn  Thr Ile Thr Lys Arg  Arg Lys Lys 
    1430                 1435                 1440             


Arg Asn  Arg Ser Ser Ser Val  Ser Ser Ser Ala Ala  Ser Ser Pro 
    1445                 1450                 1455             


Glu Arg  Lys Lys Arg Ile Leu  Lys Pro Gln Leu Lys  Ser Glu Ser 
    1460                 1465                 1470             


Ser Thr  Ser Ala Phe Ser Thr  Pro Thr Arg Ser Ile  Pro Pro Arg 
    1475                 1480                 1485             


His Asn  Ala Ala Gln Ile Asn  Gly Lys Thr Glu Ser  Ser Ser Val 
    1490                 1495                 1500             


Val Arg  Thr Arg Ser Asn Arg  Val Val Val Asp Pro  Val Val Thr 
    1505                 1510                 1515             


Glu Gln  Pro Ser Thr Ser Ser  Ala Ala Lys Thr Phe  Ile Thr Lys 
    1520                 1525                 1530             


Ala Asn  Ala Ser Ala Ile Pro  Gly Lys Thr Ile Leu  Glu Asn Ser 
    1535                 1540                 1545             


Val Lys  His Ser Lys Ala Leu  Asn Thr Leu Ser Ser  Pro Gly Gln 
    1550                 1555                 1560             


Ser Ser  Phe Ser His Gly Thr  Arg Asn Asn Ser Ala  Lys Glu Asn 
    1565                 1570                 1575             


Met Glu  Lys Glu Lys Pro Val  Lys Arg Lys Met Lys  Ser Ser Val 
    1580                 1585                 1590             


Leu Pro  Lys Ala Ser Thr Leu  Ser Lys Ser Ser Ala  Val Ile Glu 
    1595                 1600                 1605             


Gln Gly  Asp Cys Lys Asn Asn  Ala Leu Val Pro Gly  Thr Ile Gln 
    1610                 1615                 1620             


Val Asn  Gly His Gly Gly Gln  Pro Ser Lys Leu Val  Lys Arg Gly 
    1625                 1630                 1635             


Pro Gly  Arg Lys Pro Lys Val  Glu Val Asn Thr Asn  Ser Gly Glu 
    1640                 1645                 1650             


Ile Ile  His Lys Lys Arg Gly  Arg Lys Pro Lys Lys  Leu Gln Tyr 
    1655                 1660                 1665             


Ala Lys  Pro Glu Asp Leu Glu  Gln Asn Asn Val His  Pro Ile Arg 
    1670                 1675                 1680             


Asp Glu  Val Leu Pro Ser Ser  Thr Cys Asn Phe Leu  Ser Glu Thr 
    1685                 1690                 1695             


Asn Asn  Val Lys Glu Asp Leu  Leu Gln Lys Lys Asn  Arg Gly Gly 
    1700                 1705                 1710             


Arg Lys  Pro Lys Arg Lys Met  Lys Thr Gln Lys Leu  Asp Ala Asp 
    1715                 1720                 1725             


Leu Leu  Val Pro Ala Ser Val  Lys Val Leu Arg Arg  Ser Asn Arg 
    1730                 1735                 1740             


Lys Lys  Ile Asp Asp Pro Ile  Asp Glu Glu Glu Glu  Phe Glu Glu 
    1745                 1750                 1755             


Leu Lys  Gly Ser Glu Pro His  Met Arg Thr Arg Asn  Gln Gly Arg 
    1760                 1765                 1770             


Arg Thr  Ala Phe Tyr Asn Glu  Asp Asp Ser Glu Glu  Glu Gln Arg 
    1775                 1780                 1785             


Gln Leu  Leu Phe Glu Asp Thr  Ser Leu Thr Phe Gly  Thr Ser Ser 
    1790                 1795                 1800             


Arg Gly  Arg Val Arg Lys Leu  Thr Glu Lys Ala Lys  Ala Asn Leu 
    1805                 1810                 1815             


Ile Gly  Trp 
    1820     


<210>  51
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  52
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Asn Thr Gln Ala Glu Arg Ser Ile Ile Gly Met Ile Asp Met 
1               5                   10                  15      


Phe His Lys Tyr Thr Arg Arg Asp Asp Lys Ile Glu Lys Pro Ser Leu 
            20                  25                  30          


Leu Thr Met Met Lys Glu Asn Phe Pro Asn Phe Leu Ser Ala Cys Asp 
        35                  40                  45              


Lys Lys Gly Thr Asn Tyr Leu Ala Asp Val Phe Glu Lys Lys Asp Lys 
    50                  55                  60                  


Asn Glu Asp Lys Lys Ile Asp Phe Ser Glu Phe Leu Ser Leu Leu Gly 
65                  70                  75                  80  


Asp Ile Ala Thr Asp Tyr His Lys Gln Ser His Gly Ala Ala Pro Cys 
                85                  90                  95      


Ser Gly Gly Ser Gln 
            100     


<210>  53
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Lys Thr Leu Leu Leu Leu Ala Val Ile Met Ile Phe Gly Leu Leu 
1               5                   10                  15      


Gln Ala His Gly Asn Leu Val Asn Phe His Arg Met Ile Lys Leu Thr 
            20                  25                  30          


Thr Gly Lys Glu Ala Ala Leu Ser Tyr Gly Phe Tyr Gly Cys His Cys 
        35                  40                  45              


Gly Val Gly Gly Arg Gly Ser Pro Lys Asp Ala Thr Asp Arg Cys Cys 
    50                  55                  60                  


Val Thr His Asp Cys Cys Tyr Lys Arg Leu Glu Lys Arg Gly Cys Gly 
65                  70                  75                  80  


Thr Lys Phe Leu Ser Tyr Lys Phe Ser Asn Ser Gly Ser Arg Ile Thr 
                85                  90                  95      


Cys Ala Lys Gln Asp Ser Cys Arg Ser Gln Leu Cys Glu Cys Asp Lys 
            100                 105                 110         


Ala Ala Ala Thr Cys Phe Ala Arg Asn Lys Thr Thr Tyr Asn Lys Lys 
        115                 120                 125             


Tyr Gln Tyr Tyr Ser Asn Lys His Cys Arg Gly Ser Thr Pro Arg Cys 
    130                 135                 140                 


<210>  54
<211>  1215
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser 
1               5                   10                  15      


Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys 
            20                  25                  30          


Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala 
        35                  40                  45              


Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu 
    50                  55                  60                  


Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala 
65                  70                  75                  80  


Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu 
                85                  90                  95      


Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu 
            100                 105                 110         


His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys 
        115                 120                 125             


Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val 
    130                 135                 140                 


His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn 
145                 150                 155                 160 


Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu 
                165                 170                 175     


His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu 
            180                 185                 190         


Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala 
        195                 200                 205             


Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly 
    210                 215                 220                 


Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln 
225                 230                 235                 240 


Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His 
                245                 250                 255     


Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr 
            260                 265                 270         


Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys 
        275                 280                 285             


Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr 
    290                 295                 300                 


Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile 
305                 310                 315                 320 


Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro 
                325                 330                 335     


Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro 
            340                 345                 350         


Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His 
        355                 360                 365             


Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly 
    370                 375                 380                 


Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His 
385                 390                 395                 400 


Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro 
                405                 410                 415     


Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu 
            420                 425                 430         


Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp 
        435                 440                 445             


Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp 
    450                 455                 460                 


Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg 
465                 470                 475                 480 


Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp 
                485                 490                 495     


Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys 
            500                 505                 510         


Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro 
        515                 520                 525             


Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr 
    530                 535                 540                 


Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His 
545                 550                 555                 560 


Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe 
                565                 570                 575     


Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala 
            580                 585                 590         


Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro 
        595                 600                 605             


Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn 
    610                 615                 620                 


Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala 
625                 630                 635                 640 


Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr 
                645                 650                 655     


Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His 
            660                 665                 670         


Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser 
        675                 680                 685             


Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala 
    690                 695                 700                 


Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His 
705                 710                 715                 720 


Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu 
                725                 730                 735     


Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys 
            740                 745                 750         


Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly 
        755                 760                 765             


Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu 
    770                 775                 780                 


Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly 
785                 790                 795                 800 


Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala 
                805                 810                 815     


Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg 
            820                 825                 830         


Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser 
        835                 840                 845             


Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala 
    850                 855                 860                 


Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly 
865                 870                 875                 880 


Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr 
                885                 890                 895     


Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu 
            900                 905                 910         


Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala 
        915                 920                 925             


Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly 
    930                 935                 940                 


Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala 
945                 950                 955                 960 


Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu 
                965                 970                 975     


Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln 
            980                 985                 990         


Thr Thr Ser Glu Ala Ala Met Glu  Gly Ala Thr Leu Asp  Gln Thr Thr 
        995                 1000                 1005             


Ser Glu  Glu Ala Pro Gly Gly  Thr Glu Leu Ile Gln  Thr Pro Leu 
    1010                 1015                 1020             


Ala Ser  Ser Thr Asp His Gln  Thr Pro Pro Thr Ser  Pro Val Gln 
    1025                 1030                 1035             


Gly Thr  Thr Pro Gln Ile Ser  Pro Ser Thr Leu Ile  Gly Ser Leu 
    1040                 1045                 1050             


Arg Thr  Leu Glu Leu Gly Ser  Glu Ser Gln Gly Ala  Ser Glu Ser 
    1055                 1060                 1065             


Gln Ala  Pro Gly Glu Glu Asn  Leu Leu Gly Glu Ala  Ala Gly Gly 
    1070                 1075                 1080             


Gln Asp  Met Ala Asp Ser Met  Leu Met Gln Gly Ser  Arg Gly Leu 
    1085                 1090                 1095             


Thr Asp  Gln Ala Ile Phe Tyr  Ala Val Thr Pro Leu  Pro Trp Cys 
    1100                 1105                 1110             


Pro His  Leu Val Ala Val Cys  Pro Ile Pro Ala Ala  Gly Leu Asp 
    1115                 1120                 1125             


Val Thr  Gln Pro Cys Gly Asp  Cys Gly Thr Ile Gln  Glu Asn Trp 
    1130                 1135                 1140             


Val Cys  Leu Ser Cys Tyr Gln  Val Tyr Cys Gly Arg  Tyr Ile Asn 
    1145                 1150                 1155             


Gly His  Met Leu Gln His His  Gly Asn Ser Gly His  Pro Leu Val 
    1160                 1165                 1170             


Leu Ser  Tyr Ile Asp Leu Ser  Ala Trp Cys Tyr Tyr  Cys Gln Ala 
    1175                 1180                 1185             


Tyr Val  His His Gln Ala Leu  Leu Asp Val Lys Asn  Ile Ala His 
    1190                 1195                 1200             


Gln Asn  Lys Phe Gly Glu Asp  Met Pro His Pro His  
    1205                 1210                 1215 


<210>  55
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 
            260                 265                 270         


Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 
        275                 280                 285             


Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 
    290                 295                 300                 


His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 
305                 310                 315                 320 


Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 
                325                 330                 335     


Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 
            340                 345                 350         


Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 
        355                 360                 365             


Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 
    370                 375                 380                 


Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 
385                 390                 395                 400 


Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 
                405                 410                 415     


Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 
            420                 425                 430         


Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 
        435                 440                 445             


Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 
    450                 455                 460                 


Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 
465                 470                 475                 480 


Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 
                485                 490                 495     


Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 
            500                 505                 510         


Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 


<210>  56
<211>  4548
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 
            20                  25                  30          


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
        35                  40                  45              


Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 
    50                  55                  60                  


Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
65                  70                  75                  80  


Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 
                85                  90                  95      


Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 
            100                 105                 110         


Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 
        115                 120                 125             


Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 
    130                 135                 140                 


Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 
145                 150                 155                 160 


Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 
                165                 170                 175     


Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 
            180                 185                 190         


Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 
        195                 200                 205             


Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 
    210                 215                 220                 


Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 
225                 230                 235                 240 


Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 
                245                 250                 255     


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 
            260                 265                 270         


Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 
        275                 280                 285             


Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 
305                 310                 315                 320 


Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 
                325                 330                 335     


Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 
            340                 345                 350         


Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 
        355                 360                 365             


Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 
    370                 375                 380                 


Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 
385                 390                 395                 400 


Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 
                405                 410                 415     


Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 
            420                 425                 430         


Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 
        435                 440                 445             


Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 
    450                 455                 460                 


Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 
465                 470                 475                 480 


Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 
                485                 490                 495     


Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 
            500                 505                 510         


Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 
        515                 520                 525             


Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 
    530                 535                 540                 


Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 
545                 550                 555                 560 


Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 
                565                 570                 575     


Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 
            580                 585                 590         


Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 
        595                 600                 605             


Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 
    610                 615                 620                 


Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
625                 630                 635                 640 


Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 
                645                 650                 655     


Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 
            660                 665                 670         


Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 
        675                 680                 685             


Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 
    690                 695                 700                 


Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 
705                 710                 715                 720 


Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 
                725                 730                 735     


Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 
            740                 745                 750         


Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 
        755                 760                 765             


Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 
    770                 775                 780                 


Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 
785                 790                 795                 800 


Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 
                805                 810                 815     


Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 
            820                 825                 830         


Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 
        835                 840                 845             


Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 
    850                 855                 860                 


Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala 
865                 870                 875                 880 


Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu 
                885                 890                 895     


Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 
            900                 905                 910         


Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln 
        915                 920                 925             


Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 
    930                 935                 940                 


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
945                 950                 955                 960 


Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 
                965                 970                 975     


Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
            980                 985                 990         


Asp Ala Val Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
        995                 1000                 1005             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1010                 1015                 1020             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1025                 1030                 1035             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1040                 1045                 1050             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1055                 1060                 1065             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1070                 1075                 1080             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1085                 1090                 1095             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1100                 1105                 1110             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1115                 1120                 1125             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1130                 1135                 1140             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1145                 1150                 1155             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1160                 1165                 1170             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1175                 1180                 1185             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1190                 1195                 1200             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1205                 1210                 1215             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1220                 1225                 1230             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1235                 1240                 1245             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1250                 1255                 1260             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1265                 1270                 1275             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1295                 1300                 1305             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1310                 1315                 1320             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1325                 1330                 1335             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1340                 1345                 1350             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1355                 1360                 1365             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1370                 1375                 1380             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1385                 1390                 1395             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1400                 1405                 1410             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1415                 1420                 1425             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    1430                 1435                 1440             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    1445                 1450                 1455             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    1460                 1465                 1470             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    1475                 1480                 1485             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    1490                 1495                 1500             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    1505                 1510                 1515             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    1520                 1525                 1530             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    1535                 1540                 1545             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    1550                 1555                 1560             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    1565                 1570                 1575             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1580                 1585                 1590             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1595                 1600                 1605             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1610                 1615                 1620             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1625                 1630                 1635             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1640                 1645                 1650             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1655                 1660                 1665             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1670                 1675                 1680             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1685                 1690                 1695             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1700                 1705                 1710             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1715                 1720                 1725             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1730                 1735                 1740             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1745                 1750                 1755             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1760                 1765                 1770             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1775                 1780                 1785             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1790                 1795                 1800             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1805                 1810                 1815             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1820                 1825                 1830             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1835                 1840                 1845             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1850                 1855                 1860             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1865                 1870                 1875             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1880                 1885                 1890             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1895                 1900                 1905             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1910                 1915                 1920             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1925                 1930                 1935             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1940                 1945                 1950             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1955                 1960                 1965             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1970                 1975                 1980             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1985                 1990                 1995             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2000                 2005                 2010             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2015                 2020                 2025             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2030                 2035                 2040             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2045                 2050                 2055             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2060                 2065                 2070             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2075                 2080                 2085             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2090                 2095                 2100             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2105                 2110                 2115             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2120                 2125                 2130             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2135                 2140                 2145             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2150                 2155                 2160             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2165                 2170                 2175             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2180                 2185                 2190             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2195                 2200                 2205             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2210                 2215                 2220             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2225                 2230                 2235             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2240                 2245                 2250             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2255                 2260                 2265             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2270                 2275                 2280             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2285                 2290                 2295             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2300                 2305                 2310             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2315                 2320                 2325             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2330                 2335                 2340             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2345                 2350                 2355             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2360                 2365                 2370             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2375                 2380                 2385             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2390                 2395                 2400             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2405                 2410                 2415             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2420                 2425                 2430             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    2435                 2440                 2445             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    2450                 2455                 2460             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    2465                 2470                 2475             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    2480                 2485                 2490             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    2495                 2500                 2505             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    2510                 2515                 2520             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    2525                 2530                 2535             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    2540                 2545                 2550             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    2555                 2560                 2565             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2570                 2575                 2580             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2585                 2590                 2595             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2600                 2605                 2610             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2615                 2620                 2625             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2630                 2635                 2640             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2645                 2650                 2655             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2660                 2665                 2670             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2675                 2680                 2685             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2690                 2695                 2700             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2705                 2710                 2715             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2720                 2725                 2730             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2735                 2740                 2745             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2750                 2755                 2760             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2765                 2770                 2775             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2780                 2785                 2790             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2795                 2800                 2805             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2810                 2815                 2820             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2825                 2830                 2835             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2840                 2845                 2850             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2855                 2860                 2865             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2870                 2875                 2880             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2885                 2890                 2895             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2900                 2905                 2910             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2915                 2920                 2925             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2930                 2935                 2940             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2945                 2950                 2955             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2960                 2965                 2970             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2975                 2980                 2985             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2990                 2995                 3000             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3005                 3010                 3015             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    3020                 3025                 3030             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    3035                 3040                 3045             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    3050                 3055                 3060             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    3065                 3070                 3075             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    3080                 3085                 3090             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    3095                 3100                 3105             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    3110                 3115                 3120             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    3125                 3130                 3135             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    3140                 3145                 3150             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    3155                 3160                 3165             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3170                 3175                 3180             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    3185                 3190                 3195             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    3200                 3205                 3210             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    3215                 3220                 3225             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    3230                 3235                 3240             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    3245                 3250                 3255             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    3260                 3265                 3270             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    3275                 3280                 3285             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    3290                 3295                 3300             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    3305                 3310                 3315             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    3320                 3325                 3330             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    3335                 3340                 3345             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    3350                 3355                 3360             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    3365                 3370                 3375             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Pro Val Ala  Ala Pro Tyr 
    3380                 3385                 3390             


Cys Tyr  Thr Arg Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 
    3395                 3400                 3405             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    3410                 3415                 3420             


Ile Thr  Pro Ile Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    3425                 3430                 3435             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    3440                 3445                 3450             


Gln Ser  Tyr Gln Gly Thr Tyr  Phe Ile Thr Val Thr  Gly Arg Thr 
    3455                 3460                 3465             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    3470                 3475                 3480             


Pro Ala  Tyr Tyr Pro Asn Ala  Gly Leu Ile Lys Asn  Tyr Cys Arg 
    3485                 3490                 3495             


Asn Pro  Asp Pro Val Ala Ala  Pro Trp Cys Tyr Thr  Thr Asp Pro 
    3500                 3505                 3510             


Ser Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Arg Cys  Ser Asp Ala 
    3515                 3520                 3525             


Glu Trp  Thr Ala Phe Val Pro  Pro Asn Val Ile Leu  Ala Pro Ser 
    3530                 3535                 3540             


Leu Glu  Ala Phe Phe Glu Gln  Ala Leu Thr Glu Glu  Thr Pro Gly 
    3545                 3550                 3555             


Val Gln  Asp Cys Tyr Tyr His  Tyr Gly Gln Ser Tyr  Arg Gly Thr 
    3560                 3565                 3570             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3575                 3580                 3585             


Met Thr  Pro His Gln His Ser  Arg Thr Pro Glu Asn  Tyr Pro Asn 
    3590                 3595                 3600             


Ala Gly  Leu Thr Arg Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile 
    3605                 3610                 3615             


Arg Pro  Trp Cys Tyr Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr 
    3620                 3625                 3630             


Cys Asn  Leu Thr Gln Cys Leu  Val Thr Glu Ser Ser  Val Leu Ala 
    3635                 3640                 3645             


Thr Leu  Thr Val Val Pro Asp  Pro Ser Thr Glu Ala  Ser Ser Glu 
    3650                 3655                 3660             


Glu Ala  Pro Thr Glu Gln Ser  Pro Gly Val Gln Asp  Cys Tyr His 
    3665                 3670                 3675             


Gly Asp  Gly Gln Ser Tyr Arg  Gly Ser Phe Ser Thr  Thr Val Thr 
    3680                 3685                 3690             


Gly Arg  Thr Cys Gln Ser Trp  Ser Ser Met Thr Pro  His Trp His 
    3695                 3700                 3705             


Gln Arg  Thr Thr Glu Tyr Tyr  Pro Asn Gly Gly Leu  Thr Arg Asn 
    3710                 3715                 3720             


Tyr Cys  Arg Asn Pro Asp Ala  Glu Ile Ser Pro Trp  Cys Tyr Thr 
    3725                 3730                 3735             


Met Asp  Pro Asn Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3740                 3745                 3750             


Pro Val  Thr Glu Ser Ser Val  Leu Ala Thr Ser Thr  Ala Val Ser 
    3755                 3760                 3765             


Glu Gln  Ala Pro Thr Glu Gln  Ser Pro Thr Val Gln  Asp Cys Tyr 
    3770                 3775                 3780             


His Gly  Asp Gly Gln Ser Tyr  Arg Gly Ser Phe Ser  Thr Thr Val 
    3785                 3790                 3795             


Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Thr  Pro His Trp 
    3800                 3805                 3810             


His Gln  Arg Thr Thr Glu Tyr  Tyr Pro Asn Gly Gly  Leu Thr Arg 
    3815                 3820                 3825             


Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile Arg Pro  Trp Cys Tyr 
    3830                 3835                 3840             


Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 
    3845                 3850                 3855             


Cys Pro  Val Met Glu Ser Thr  Leu Leu Thr Thr Pro  Thr Val Val 
    3860                 3865                 3870             


Pro Val  Pro Ser Thr Glu Leu  Pro Ser Glu Glu Ala  Pro Thr Glu 
    3875                 3880                 3885             


Asn Ser  Thr Gly Val Gln Asp  Cys Tyr Arg Gly Asp  Gly Gln Ser 
    3890                 3895                 3900             


Tyr Arg  Gly Thr Leu Ser Thr  Thr Ile Thr Gly Arg  Thr Cys Gln 
    3905                 3910                 3915             


Ser Trp  Ser Ser Met Thr Pro  His Trp His Arg Arg  Ile Pro Leu 
    3920                 3925                 3930             


Tyr Tyr  Pro Asn Ala Gly Leu  Thr Arg Asn Tyr Cys  Arg Asn Pro 
    3935                 3940                 3945             


Asp Ala  Glu Ile Arg Pro Trp  Cys Tyr Thr Met Asp  Pro Ser Val 
    3950                 3955                 3960             


Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Pro Val  Thr Glu Ser 
    3965                 3970                 3975             


Ser Val  Leu Thr Thr Pro Thr  Val Ala Pro Val Pro  Ser Thr Glu 
    3980                 3985                 3990             


Ala Pro  Ser Glu Gln Ala Pro  Pro Glu Lys Ser Pro  Val Val Gln 
    3995                 4000                 4005             


Asp Cys  Tyr His Gly Asp Gly  Arg Ser Tyr Arg Gly  Ile Ser Ser 
    4010                 4015                 4020             


Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ser Trp Ser  Ser Met Ile 
    4025                 4030                 4035             


Pro His  Trp His Gln Arg Thr  Pro Glu Asn Tyr Pro  Asn Ala Gly 
    4040                 4045                 4050             


Leu Thr  Glu Asn Tyr Cys Arg  Asn Pro Asp Ser Gly  Lys Gln Pro 
    4055                 4060                 4065             


Trp Cys  Tyr Thr Thr Asp Pro  Cys Val Arg Trp Glu  Tyr Cys Asn 
    4070                 4075                 4080             


Leu Thr  Gln Cys Ser Glu Thr  Glu Ser Gly Val Leu  Glu Thr Pro 
    4085                 4090                 4095             


Thr Val  Val Pro Val Pro Ser  Met Glu Ala His Ser  Glu Ala Ala 
    4100                 4105                 4110             


Pro Thr  Glu Gln Thr Pro Val  Val Arg Gln Cys Tyr  His Gly Asn 
    4115                 4120                 4125             


Gly Gln  Ser Tyr Arg Gly Thr  Phe Ser Thr Thr Val  Thr Gly Arg 
    4130                 4135                 4140             


Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Arg  His Gln Arg 
    4145                 4150                 4155             


Thr Pro  Glu Asn Tyr Pro Asn  Asp Gly Leu Thr Met  Asn Tyr Cys 
    4160                 4165                 4170             


Arg Asn  Pro Asp Ala Asp Thr  Gly Pro Trp Cys Phe  Thr Met Asp 
    4175                 4180                 4185             


Pro Ser  Ile Arg Trp Glu Tyr  Cys Asn Leu Thr Arg  Cys Ser Asp 
    4190                 4195                 4200             


Thr Glu  Gly Thr Val Val Ala  Pro Pro Thr Val Ile  Gln Val Pro 
    4205                 4210                 4215             


Ser Leu  Gly Pro Pro Ser Glu  Gln Asp Cys Met Phe  Gly Asn Gly 
    4220                 4225                 4230             


Lys Gly  Tyr Arg Gly Lys Lys  Ala Thr Thr Val Thr  Gly Thr Pro 
    4235                 4240                 4245             


Cys Gln  Glu Trp Ala Ala Gln  Glu Pro His Arg His  Ser Thr Phe 
    4250                 4255                 4260             


Ile Pro  Gly Thr Asn Lys Trp  Ala Gly Leu Glu Lys  Asn Tyr Cys 
    4265                 4270                 4275             


Arg Asn  Pro Asp Gly Asp Ile  Asn Gly Pro Trp Cys  Tyr Thr Met 
    4280                 4285                 4290             


Asn Pro  Arg Lys Leu Phe Asp  Tyr Cys Asp Ile Pro  Leu Cys Ala 
    4295                 4300                 4305             


Ser Ser  Ser Phe Asp Cys Gly  Lys Pro Gln Val Glu  Pro Lys Lys 
    4310                 4315                 4320             


Cys Pro  Gly Ser Ile Val Gly  Gly Cys Val Ala His  Pro His Ser 
    4325                 4330                 4335             


Trp Pro  Trp Gln Val Ser Leu  Arg Thr Arg Phe Gly  Lys His Phe 
    4340                 4345                 4350             


Cys Gly  Gly Thr Leu Ile Ser  Pro Glu Trp Val Leu  Thr Ala Ala 
    4355                 4360                 4365             


His Cys  Leu Lys Lys Ser Ser  Arg Pro Ser Ser Tyr  Lys Val Ile 
    4370                 4375                 4380             


Leu Gly  Ala His Gln Glu Val  Asn Leu Glu Ser His  Val Gln Glu 
    4385                 4390                 4395             


Ile Glu  Val Ser Arg Leu Phe  Leu Glu Pro Thr Gln  Ala Asp Ile 
    4400                 4405                 4410             


Ala Leu  Leu Lys Leu Ser Arg  Pro Ala Val Ile Thr  Asp Lys Val 
    4415                 4420                 4425             


Met Pro  Ala Cys Leu Pro Ser  Pro Asp Tyr Met Val  Thr Ala Arg 
    4430                 4435                 4440             


Thr Glu  Cys Tyr Ile Thr Gly  Trp Gly Glu Thr Gln  Gly Thr Phe 
    4445                 4450                 4455             


Gly Thr  Gly Leu Leu Lys Glu  Ala Gln Leu Leu Val  Ile Glu Asn 
    4460                 4465                 4470             


Glu Val  Cys Asn His Tyr Lys  Tyr Ile Cys Ala Glu  His Leu Ala 
    4475                 4480                 4485             


Arg Gly  Thr Asp Ser Cys Gln  Gly Asp Ser Gly Gly  Pro Leu Val 
    4490                 4495                 4500             


Cys Phe  Glu Lys Asp Lys Tyr  Ile Leu Gln Gly Val  Thr Ser Trp 
    4505                 4510                 4515             


Gly Leu  Gly Cys Ala Arg Pro  Asn Lys Pro Gly Val  Tyr Ala Arg 
    4520                 4525                 4530             


Val Ser  Arg Phe Val Thr Trp  Ile Glu Gly Met Met  Arg Asn Asn 
    4535                 4540                 4545             


<210>  57
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Glu Pro Gln Pro Pro Ser Gly Gly Leu Thr Asp Glu Ala Ala 
1               5                   10                  15      


Leu Ser Cys Cys Ser Asp Ala Asp Pro Ser Thr Lys Asp Phe Leu Leu 
            20                  25                  30          


Gln Gln Thr Met Leu Arg Val Lys Asp Pro Lys Lys Ser Leu Asp Phe 
        35                  40                  45              


Tyr Thr Arg Val Leu Gly Met Thr Leu Ile Gln Lys Cys Asp Phe Pro 
    50                  55                  60                  


Ile Met Lys Phe Ser Leu Tyr Phe Leu Ala Tyr Glu Asp Lys Asn Asp 
65                  70                  75                  80  


Ile Pro Lys Glu Lys Asp Glu Lys Ile Ala Trp Ala Leu Ser Arg Lys 
                85                  90                  95      


Ala Thr Leu Glu Leu Thr His Asn Trp Gly Thr Glu Asp Asp Glu Thr 
            100                 105                 110         


Gln Ser Tyr His Asn Gly Asn Ser Asp Pro Arg Gly Phe Gly His Ile 
        115                 120                 125             


Gly Ile Ala Val Pro Asp Val Tyr Ser Ala Cys Lys Arg Phe Glu Glu 
    130                 135                 140                 


Leu Gly Val Lys Phe Val Lys Lys Pro Asp Asp Gly Lys Met Lys Gly 
145                 150                 155                 160 


Leu Ala Phe Ile Gln Asp Pro Asp Gly Tyr Trp Ile Glu Ile Leu Asn 
                165                 170                 175     


Pro Asn Lys Met Ala Thr Leu Met 
            180                 


<210>  58
<211>  1824
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile 
1               5                   10                  15      


Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln 
            20                  25                  30          


Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln 
        35                  40                  45              


Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser 
    50                  55                  60                  


Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg 
65                  70                  75                  80  


Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val 
                85                  90                  95      


His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val 
            100                 105                 110         


Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu 
        115                 120                 125             


Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Lys Ala Gln Ser Asn Gly 
    130                 135                 140                 


Pro Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala 
                165                 170                 175     


Leu Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp 
            180                 185                 190         


Val Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu 
        195                 200                 205             


Thr Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg 
    210                 215                 220                 


Arg Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser 
225                 230                 235                 240 


Asp Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser 
                245                 250                 255     


Leu Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp 
            260                 265                 270         


Pro Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu 
        275                 280                 285             


Lys Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro 
    290                 295                 300                 


Gly Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp 
305                 310                 315                 320 


Asp Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys 
                325                 330                 335     


Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro 
            340                 345                 350         


Lys Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu 
        355                 360                 365             


Arg Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu 
    370                 375                 380                 


Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe Ala Tyr 
385                 390                 395                 400 


Tyr Asn Tyr His Thr Tyr Glu Asp Gly Ser Asp Ser Arg Asp Lys Pro 
                405                 410                 415     


Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys 
            420                 425                 430         


Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His 
        435                 440                 445             


His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg 
    450                 455                 460                 


Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr 
465                 470                 475                 480 


Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val 
                485                 490                 495     


Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser 
            500                 505                 510         


Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile 
        515                 520                 525             


Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr 
    530                 535                 540                 


Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile 
                565                 570                 575     


Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln 
            580                 585                 590         


Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg 
        595                 600                 605             


Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn 
    610                 615                 620                 


Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met 
625                 630                 635                 640 


Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro 
                645                 650                 655     


Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser 
            660                 665                 670         


Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu 
        675                 680                 685             


Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln 
    690                 695                 700                 


Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala 
705                 710                 715                 720 


His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser 
                725                 730                 735     


Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn 
            740                 745                 750         


Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly 
        755                 760                 765             


Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile 
    770                 775                 780                 


Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn 
785                 790                 795                 800 


Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly 
                805                 810                 815     


Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys 
            820                 825                 830         


Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln 
        835                 840                 845             


Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro 
    850                 855                 860                 


Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala 
865                 870                 875                 880 


Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr 
                885                 890                 895     


Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu 
            900                 905                 910         


Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp 
        915                 920                 925             


Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val 
    930                 935                 940                 


Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys 
945                 950                 955                 960 


Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr 
                965                 970                 975     


Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg 
            980                 985                 990         


Glu Asn Thr Glu Leu Ala Gln Pro  Leu Arg Lys Glu Pro  Glu Ile Ile 
        995                 1000                 1005             


Thr Val  Thr Leu Lys Lys Gln  Asn Gly Met Gly Leu  Ser Ile Val 
    1010                 1015                 1020             


Ala Ala  Lys Gly Ala Gly Gln  Asp Lys Leu Gly Ile  Tyr Val Lys 
    1025                 1030                 1035             


Ser Val  Val Lys Gly Gly Ala  Ala Asp Val Asp Gly  Arg Leu Ala 
    1040                 1045                 1050             


Ala Gly  Asp Gln Leu Leu Ser  Val Asp Gly Arg Ser  Leu Val Gly 
    1055                 1060                 1065             


Leu Ser  Gln Glu Arg Ala Ala  Glu Leu Met Thr Arg  Thr Ser Ser 
    1070                 1075                 1080             


Val Val  Thr Leu Glu Val Ala  Lys Gln Gly Ala Ile  Tyr His Gly 
    1085                 1090                 1095             


Leu Ala  Thr Leu Leu Asn Gln  Pro Ser Pro Met Met  Gln Arg Ile 
    1100                 1105                 1110             


Ser Asp  Arg Arg Gly Ser Gly  Lys Pro Arg Pro Lys  Ser Glu Gly 
    1115                 1120                 1125             


Phe Glu  Leu Tyr Asn Asn Ser  Thr Gln Asn Gly Ser  Pro Glu Ser 
    1130                 1135                 1140             


Pro Gln  Leu Pro Trp Ala Glu  Tyr Ser Glu Pro Lys  Lys Leu Pro 
    1145                 1150                 1155             


Gly Asp  Asp Arg Leu Met Lys  Asn Arg Ala Asp His  Arg Ser Ser 
    1160                 1165                 1170             


Pro Asn  Val Ala Asn Gln Pro  Pro Ser Pro Gly Gly  Lys Ser Ala 
    1175                 1180                 1185             


Tyr Ala  Ser Gly Thr Thr Ala  Lys Ile Thr Ser Val  Ser Thr Gly 
    1190                 1195                 1200             


Asn Leu  Cys Thr Glu Glu Gln  Thr Pro Pro Pro Arg  Pro Glu Ala 
    1205                 1210                 1215             


Tyr Pro  Ile Pro Thr Gln Thr  Tyr Thr Arg Glu Tyr  Phe Thr Phe 
    1220                 1225                 1230             


Pro Ala  Ser Lys Ser Gln Asp  Arg Met Ala Pro Pro  Gln Asn Gln 
    1235                 1240                 1245             


Trp Pro  Asn Tyr Glu Glu Lys  Pro His Met His Thr  Asp Ser Asn 
    1250                 1255                 1260             


His Ser  Ser Ile Ala Ile Gln  Arg Val Thr Arg Ser  Gln Glu Glu 
    1265                 1270                 1275             


Leu Arg  Glu Asp Lys Ala Tyr  Gln Leu Glu Arg His  Arg Ile Glu 
    1280                 1285                 1290             


Ala Ala  Met Asp Arg Lys Ser  Asp Ser Asp Met Trp  Ile Asn Gln 
    1295                 1300                 1305             


Ser Ser  Ser Leu Asp Ser Ser  Thr Ser Ser Gln Glu  His Leu Asn 
    1310                 1315                 1320             


His Ser  Ser Lys Ser Val Thr  Pro Ala Ser Thr Leu  Thr Lys Ser 
    1325                 1330                 1335             


Gly Pro  Gly Arg Trp Lys Thr  Pro Ala Ala Ile Pro  Ala Thr Pro 
    1340                 1345                 1350             


Val Ala  Val Ser Gln Pro Ile  Arg Thr Asp Leu Pro  Pro Pro Pro 
    1355                 1360                 1365             


Pro Pro  Pro Pro Val His Tyr  Ala Gly Asp Phe Asp  Gly Met Ser 
    1370                 1375                 1380             


Met Asp  Leu Pro Leu Pro Pro  Pro Pro Ser Ala Asn  Gln Ile Gly 
    1385                 1390                 1395             


Leu Pro  Ser Ala Gln Val Ala  Ala Ala Glu Arg Arg  Lys Arg Glu 
    1400                 1405                 1410             


Glu His  Gln Arg Trp Tyr Glu  Lys Glu Lys Ala Arg  Leu Glu Glu 
    1415                 1420                 1425             


Glu Arg  Glu Arg Lys Arg Arg  Glu Gln Glu Arg Lys  Leu Gly Gln 
    1430                 1435                 1440             


Met Arg  Thr Gln Ser Leu Asn  Pro Ala Pro Phe Ser  Pro Leu Thr 
    1445                 1450                 1455             


Ala Gln  Gln Met Lys Pro Glu  Lys Pro Ser Thr Leu  Gln Arg Pro 
    1460                 1465                 1470             


Gln Glu  Thr Val Ile Arg Glu  Leu Gln Pro Gln Gln  Gln Pro Arg 
    1475                 1480                 1485             


Thr Ile  Glu Arg Arg Asp Leu  Gln Tyr Ile Thr Val  Ser Lys Glu 
    1490                 1495                 1500             


Glu Leu  Ser Ser Gly Asp Ser  Leu Ser Pro Asp Pro  Trp Lys Arg 
    1505                 1510                 1515             


Asp Ala  Lys Glu Lys Leu Glu  Lys Gln Gln Gln Met  His Ile Val 
    1520                 1525                 1530             


Asp Met  Leu Ser Lys Glu Ile  Gln Glu Leu Gln Ser  Lys Pro Asp 
    1535                 1540                 1545             


Arg Ser  Ala Glu Glu Ser Asp  Arg Leu Arg Lys Leu  Met Leu Glu 
    1550                 1555                 1560             


Trp Gln  Phe Gln Lys Arg Leu  Gln Glu Ser Lys Gln  Lys Asp Glu 
    1565                 1570                 1575             


Asp Asp  Glu Glu Glu Glu Asp  Asp Asp Val Asp Thr  Met Leu Ile 
    1580                 1585                 1590             


Met Gln  Arg Leu Glu Ala Glu  Arg Arg Ala Arg Leu  Gln Asp Glu 
    1595                 1600                 1605             


Glu Arg  Arg Arg Gln Gln Gln  Leu Glu Glu Met Arg  Lys Arg Glu 
    1610                 1615                 1620             


Ala Glu  Asp Arg Ala Arg Gln  Glu Glu Glu Arg Arg  Arg Gln Glu 
    1625                 1630                 1635             


Glu Glu  Arg Thr Lys Arg Asp  Ala Glu Glu Lys Arg  Arg Gln Glu 
    1640                 1645                 1650             


Glu Gly  Tyr Tyr Ser Arg Leu  Glu Ala Glu Arg Arg  Arg Gln His 
    1655                 1660                 1665             


Asp Glu  Ala Ala Arg Arg Leu  Leu Glu Pro Glu Ala  Pro Gly Leu 
    1670                 1675                 1680             


Cys Arg  Pro Pro Leu Pro Arg  Asp Tyr Glu Pro Pro  Ser Pro Ser 
    1685                 1690                 1695             


Pro Ala  Pro Gly Ala Pro Pro  Pro Pro Pro Gln Arg  Asn Ala Ser 
    1700                 1705                 1710             


Tyr Leu  Lys Thr Gln Val Leu  Ser Pro Asp Ser Leu  Phe Thr Ala 
    1715                 1720                 1725             


Lys Phe  Val Ala Tyr Asn Glu  Glu Glu Glu Glu Glu  Asp Cys Ser 
    1730                 1735                 1740             


Leu Ala  Gly Pro Asn Ser Tyr  Pro Gly Ser Thr Gly  Ala Ala Val 
    1745                 1750                 1755             


Gly Ala  His Asp Ala Cys Arg  Asp Ala Lys Glu Lys  Arg Ser Lys 
    1760                 1765                 1770             


Ser Gln  Asp Ala Asp Ser Pro  Gly Ser Ser Gly Ala  Pro Glu Asn 
    1775                 1780                 1785             


Leu Thr  Phe Lys Glu Arg Gln  Arg Leu Phe Ser Gln  Gly Gln Asp 
    1790                 1795                 1800             


Val Ser  Asn Lys Val Lys Ala  Ser Arg Lys Leu Thr  Glu Leu Glu 
    1805                 1810                 1815             


Asn Glu  Leu Asn Thr Lys 
    1820                 


<210>  59
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
1               5                   10                  15      


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
            20                  25                  30          


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
        35                  40                  45              


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
65                  70                  75                  80  


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln 
                85                  90                  95      


Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
            100                 105                 110         


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
        115                 120                 125             


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
145                 150                 155                 160 


Phe Gly Arg Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
                165                 170                 175     


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
            180                 185                 190         


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
        195                 200                 205             


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
    210                 215                 220                 


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
225                 230                 235                 240 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
                245                 250                 255     


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
            260                 265                 270         


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly 
        275                 280                 285             


Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg 
    290                 295                 300                 


Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu 
305                 310                 315                 320 


Tyr Leu Ile Pro Gln Gln Gly 
                325         


<210>  60
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG

<400>  60

Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
1               5                   10                  15      


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
            20                  25                  30          


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
        35                  40                  45              


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
65                  70                  75                  80  


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Met Gln 
                85                  90                  95      


Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
            100                 105                 110         


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
        115                 120                 125             


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
145                 150                 155                 160 


Phe Gly Arg Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
                165                 170                 175     


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
            180                 185                 190         


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
        195                 200                 205             


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
    210                 215                 220                 


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
225                 230                 235                 240 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
                245                 250                 255     


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
            260                 265                 270         


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly 
        275                 280                 285             


Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg 
    290                 295                 300                 


Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu 
305                 310                 315                 320 


Tyr Leu Ile Pro Gln Gln Gly 
                325         


<210>  61
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG

<400>  61

Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
1               5                   10                  15      


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
            20                  25                  30          


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
        35                  40                  45              


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
65                  70                  75                  80  


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Met Gln 
                85                  90                  95      


Leu Met Pro Phe Gly Ser Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
            100                 105                 110         


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
        115                 120                 125             


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
145                 150                 155                 160 


Phe Gly Arg Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
                165                 170                 175     


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
            180                 185                 190         


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
        195                 200                 205             


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
    210                 215                 220                 


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
225                 230                 235                 240 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
                245                 250                 255     


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
            260                 265                 270         


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly 
        275                 280                 285             


Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg 
    290                 295                 300                 


Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu 
305                 310                 315                 320 


Tyr Leu Ile Pro Gln Gln Gly 
                325         


<210>  62
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG

<400>  62

Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
1               5                   10                  15      


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
            20                  25                  30          


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
        35                  40                  45              


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
65                  70                  75                  80  


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Met Gln 
                85                  90                  95      


Leu Met Pro Phe Gly Cys Gly Leu Asp Tyr Val Arg Glu His Lys Asp 
            100                 105                 110         


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
        115                 120                 125             


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
145                 150                 155                 160 


Phe Gly Arg Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
                165                 170                 175     


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
            180                 185                 190         


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
        195                 200                 205             


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
    210                 215                 220                 


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
225                 230                 235                 240 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
                245                 250                 255     


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
            260                 265                 270         


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly 
        275                 280                 285             


Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg 
    290                 295                 300                 


Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu 
305                 310                 315                 320 


Tyr Leu Ile Pro Gln Gln Gly 
                325         


<210>  63
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epidermal growth factor receptor (BCR-ABL)

<400>  63

Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met 
1               5                   10                  15      


Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Glu Gly Val 
            20                  25                  30          


Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp 
        35                  40                  45              


Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu 
    50                  55                  60                  


Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Arg Glu 
65                  70                  75                  80  


Pro Pro Phe Tyr Ile Ile Ile Glu Phe Met Thr Tyr Gly Asn Leu Leu 
                85                  90                  95      


Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn Ala Val Val Leu 
            100                 105                 110         


Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys 
        115                 120                 125             


Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly 
    130                 135                 140                 


Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met 
145                 150                 155                 160 


Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys 
                165                 170                 175     


Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe Ser Ile Lys Ser 
            180                 185                 190         


Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly 
        195                 200                 205             


Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Glu Leu Leu 
    210                 215                 220                 


Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys Pro Glu Lys Val 
225                 230                 235                 240 


Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro Ser Asp Arg Pro 
                245                 250                 255     


Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met Phe Gln Glu Ser 
            260                 265                 270         


<210>  64
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCR-ABL

<400>  64

Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys 
1               5                   10                  15      


His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Glu Gly Val Trp 
            20                  25                  30          


Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr 
        35                  40                  45              


Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile 
    50                  55                  60                  


Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Arg Glu Pro 
65                  70                  75                  80  


Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr Gly Asn Leu Leu Asp 
                85                  90                  95      


Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn Ala Val Val Leu Leu 
            100                 105                 110         


Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys 
        115                 120                 125             


Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu 
    130                 135                 140                 


Asn His Leu Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr 
145                 150                 155                 160 


Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp 
                165                 170                 175     


Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe Ser Ile Lys Ser Asp 
            180                 185                 190         


Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met 
        195                 200                 205             


Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Glu Leu Leu Glu 
    210                 215                 220                 


Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys Pro Glu Lys Val Tyr 
225                 230                 235                 240 


Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro Ser Asp Arg Pro Ser 
                245                 250                 255     


Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met Phe Gln Glu Ser 
            260                 265                 270     


<210>  65
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg Thr Ser Thr 
1               5                   10                  15      


Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly Lys Thr Ser 
            20                  25                  30          


Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Thr Leu Ile 
        35                  40                  45              


Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln Val 
    50                  55                  60                  


Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys Thr 
65                  70                  75                  80  


Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met Glu 
                85                  90                  95      


Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val Arg Cys Ile 
            100                 105                 110         


Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Met Leu Glu Leu Met 
        115                 120                 125             


Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg Pro Arg Pro 
    130                 135                 140                 


Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His Val Ala Arg 
145                 150                 155                 160 


Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His Phe Ile His 
                165                 170                 175     


Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro Gly Pro Gly 
            180                 185                 190         


Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg 
        195                 200                 205             


Ala Gly Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro Val Lys Trp 
    210                 215                 220                 


Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser Lys Thr Asp 
225                 230                 235                 240 


Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr 
                245                 250                 255     


Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu Phe Val Thr 
            260                 265                 270         


Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly Pro Val Tyr 
        275                 280                 285             


Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp Arg Pro Asn 
    290                 295                 300                 


Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln Asp Pro Asp 
305                 310                 315                 320 


Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu Val Glu Glu 
                325                 330                 335     


Glu Glu Lys 
            


<210>  66
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  66

Val Phe His Lys Ile Arg Asn Glu Asp Leu Ile Phe Asn Glu Ser Leu 
1               5                   10                  15      


Gly Gln Gly Thr Phe Thr Lys Ile Phe Lys Gly Val Arg Arg Glu Val 
            20                  25                  30          


Gly Asp Tyr Gly Gln Leu His Glu Thr Glu Val Leu Leu Lys Val Leu 
        35                  40                  45              


Asp Lys Ala His Arg Asn Tyr Ser Glu Ser Phe Phe Glu Ala Ala Ser 
    50                  55                  60                  


Met Met Ser Lys Leu Ser His Lys His Leu Val Leu Asn Tyr Gly Val 
65                  70                  75                  80  


Cys Phe Cys Gly Asp Glu Asn Ile Leu Val Gln Glu Phe Val Lys Phe 
                85                  90                  95      


Gly Ser Leu Asp Thr Tyr Leu Lys Lys Asn Lys Asn Cys Ile Asn Ile 
            100                 105                 110         


Leu Trp Lys Leu Glu Val Ala Lys Gln Leu Ala Trp Ala Met His Phe 
        115                 120                 125             


Leu Glu Glu Asn Thr Leu Ile His Gly Asn Val Cys Ala Lys Asn Ile 
    130                 135                 140                 


Leu Leu Ile Arg Glu Glu Asp Arg Lys Thr Gly Asn Pro Pro Phe Ile 
145                 150                 155                 160 


Lys Leu Ser Asp Pro Gly Ile Ser Ile Thr Val Leu Pro Lys Asp Ile 
                165                 170                 175     


Leu Gln Glu Arg Ile Pro Trp Val Pro Pro Glu Cys Ile Glu Asn Pro 
            180                 185                 190         


Lys Asn Leu Asn Leu Ala Thr Asp Lys Trp Ser Phe Gly Thr Thr Leu 
        195                 200                 205             


Trp Glu Ile Cys Ser Gly Gly Asp Lys Pro Leu Ser Ala Leu Asp Ser 
    210                 215                 220                 


Gln Arg Lys Leu Gln Phe Tyr Glu Asp Arg His Gln Leu Pro Ala Pro 
225                 230                 235                 240 


Lys Ala Ala Glu Leu Ala Asn Leu Ile Asn Asn Cys Met Asp Tyr Glu 
                245                 250                 255     


Pro Asp His Arg Pro Ser Phe Arg Ala Ile Ile Arg Asp Leu Asn Ser 
            260                 265                 270         


Leu Phe Thr Pro Asp 
        275         


<210>  67
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  67

Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
            20                  25                  30          


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
        35                  40                  45              


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
    50                  55                  60                  


Ile Leu Leu Phe Met Gly Tyr Ser Thr Ala Pro Gln Leu Ala Ile Val 
65                  70                  75                  80  


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ala Ser 
                85                  90                  95      


Glu Thr Lys Phe Glu Met Lys Lys Leu Ile Asp Ile Ala Arg Gln Thr 
            100                 105                 110         


Ala Arg Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
        115                 120                 125             


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Asn Thr Val Lys Ile 
    130                 135                 140                 


Gly Asp Phe Gly Leu Ala Thr Glu Lys Ser Arg Trp Ser Gly Ser His 
145                 150                 155                 160 


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
                165                 170                 175     


Ile Arg Met Gln Asp Ser Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
            180                 185                 190         


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
        195                 200                 205             


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Glu Met Val Gly Arg Gly 
    210                 215                 220                 


Ser Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Arg 
225                 230                 235                 240 


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
                245                 250                 255     


Pro Ser Phe Pro Arg Ile Leu Ala Glu Ile Glu Glu Leu Ala Arg Glu 
            260                 265                 270         


<210>  68
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA scFv variable light chain (VL)

<400>  68

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  69
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a signal peptide

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp 
            20          


<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFV to BCMA variable heavy chain (VH)

<400>  70

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Val Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Whitlow linker

<400>  71

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  72
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8 alpha chain hinge region

<400>  72

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  73
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of co-stimulatory 4-1BB protein

<400>  73

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  74
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD-zeta domain

<400>  74

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG derivative of FKBP12 with F36V mutation

<400>  75

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  76

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  77
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA-CAR-dTAG

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Asp Ile Val Leu Thr Gln Ser Pro Pro Ser 
            20                  25                  30          


Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val 
65                  70                  75                  80  


Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys 
145                 150                 155                 160 


Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Arg His Tyr Ser Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Lys Trp Met Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr 
        195                 200                 205             


Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala 
    210                 215                 220                 


Ser Thr Ala Tyr Leu Val Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala 
225                 230                 235                 240 


Ser Tyr Phe Cys Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly 
                245                 250                 255     


Gln Gly Thr Ala Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly Val Gln Val Glu 
                485                 490                 495     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            500                 505                 510         


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        515                 520                 525             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    530                 535                 540                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
545                 550                 555                 560 


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                565                 570                 575     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            580                 585                 590         


Glu Leu Leu Lys Leu Glu Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
        595                 600                 605             


Ala 
    


<210>  78
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA scFv variable light chain (VL)

<400>  78

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  79
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to BCMA variable heavy chain (VH)

<400>  79

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Val Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  80
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCMA-CAR-dTAG

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Asp Ile Val Leu Thr Gln Ser Pro Pro Ser 
            20                  25                  30          


Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val 
65                  70                  75                  80  


Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
            260                 265                 270         


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr Ser 
        275                 280                 285             


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
    290                 295                 300                 


Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe Lys 
305                 310                 315                 320 


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
                325                 330                 335     


Val Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Ser Tyr Phe Cys Ser 
            340                 345                 350         


Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Thr Leu 
        355                 360                 365             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    370                 375                 380                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
385                 390                 395                 400 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                405                 410                 415     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            420                 425                 430         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        435                 440                 445             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    450                 455                 460                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
465                 470                 475                 480 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                485                 490                 495     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            500                 505                 510         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        515                 520                 525             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    530                 535                 540                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
545                 550                 555                 560 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                565                 570                 575     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            580                 585                 590         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        595                 600                 605             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    610                 615                 620                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
625                 630                 635                 640 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                645                 650                 655     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            660                 665                 670         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        675                 680                 685             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Thr Thr Thr 
    690                 695                 700                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
705                 710                 715                 720 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                725                 730                 735     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            740                 745                 750         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        755                 760                 765             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    770                 775                 780                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
785                 790                 795                 800 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                805                 810                 815     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            820                 825                 830         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        835                 840                 845             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    850                 855                 860                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
865                 870                 875                 880 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                885                 890                 895     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            900                 905                 910         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly 
        915                 920                 925             


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
    930                 935                 940                 


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
945                 950                 955                 960 


Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
                965                 970                 975     


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
            980                 985                 990         


Met Ser Val Gly Gln Arg Ala Lys  Leu Thr Ile Ser Pro  Asp Tyr Ala 
        995                 1000                 1005             


Tyr Gly  Ala Thr Gly His Pro  Gly Ile Ile Pro Pro  His Ala Thr 
    1010                 1015                 1020             


Leu Val  Phe Asp Val Glu Leu  Leu Lys Leu Glu Gly  Gly Tyr Pro 
    1025                 1030                 1035             


Tyr Asp  Val Pro Asp Tyr Ala  
    1040                 1045 


<210>  81
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 scFV variable light chain (VL)

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  82
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to CD38 variable heavy chain (VH)

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Arg Phe Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Ile Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Pro Gly Glu Arg Asp Pro Asp Ala Val Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-CAR-dTAG

<400>  83

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Arg Ile Ile Arg Phe Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
        195                 200                 205             


Gln Gly Arg Val Thr Leu Ile Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Gly Glu Pro Gly Glu Arg Asp Pro Asp Ala Val Asp Ile Trp Gly 
                245                 250                 255     


Gln Gly Thr Met Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly Val Gln Val Glu 
                485                 490                 495     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            500                 505                 510         


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        515                 520                 525             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    530                 535                 540                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
545                 550                 555                 560 


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                565                 570                 575     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            580                 585                 590         


Glu Leu Leu Lys Leu Glu Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
        595                 600                 605             


Ala 
    


<210>  84
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to CD38 variable heavy chain (VH)

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Arg Phe Leu Gly Lys Thr Asn His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Pro Gly Asp Arg Asp Pro Asp Ala Val Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  85
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-CAR-dTAG

<400>  85

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Arg Ile Ile Arg Phe Leu Gly Lys Thr Asn His Ala Gln Lys Phe 
        195                 200                 205             


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Gly Glu Pro Gly Asp Arg Asp Pro Asp Ala Val Asp Ile Trp Gly 
                245                 250                 255     


Gln Gly Thr Met Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly Val Gln Val Glu 
                485                 490                 495     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            500                 505                 510         


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        515                 520                 525             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    530                 535                 540                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
545                 550                 555                 560 


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                565                 570                 575     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            580                 585                 590         


Glu Leu Leu Lys Leu Glu Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
        595                 600                 605             


Ala 
    


<210>  86
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 scFv variable light chain (VL)

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  87
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv to CD38 variable heavy chain (VH)

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Gly Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Val Phe Leu Gly Lys Val Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Glu Pro Gly Ala Arg Asp Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-CAR-dTAG

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Arg Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
    50                  55                  60                  


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Gly Thr Phe Arg Ser Tyr 
                165                 170                 175     


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            180                 185                 190         


Gly Arg Ile Ile Val Phe Leu Gly Lys Val Asn Tyr Ala Gln Arg Phe 
        195                 200                 205             


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Gly Glu Pro Gly Ala Arg Asp Pro Asp Ala Phe Asp Ile Trp Gly 
                245                 250                 255     


Gln Gly Thr Met Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly Val Gln Val Glu 
                485                 490                 495     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            500                 505                 510         


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        515                 520                 525             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    530                 535                 540                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
545                 550                 555                 560 


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                565                 570                 575     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            580                 585                 590         


Glu Leu Leu Lys Leu Glu Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
        595                 600                 605             


Ala 
    


<210>  89
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 scFv variable light chain (VL)

<400>  89

Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
        35                  40                  45              


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105     


<210>  90
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFV to CD19 variable heavy chain (VH)

<400>  90

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  91
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG derivative of BD1

<400>  91

Asn Pro Pro Pro Pro Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln 
1               5                   10                  15      


Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp 
            20                  25                  30          


Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys 
        35                  40                  45              


Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met 
    50                  55                  60                  


Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln 
65                  70                  75                  80  


Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr 
                85                  90                  95      


Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys 
            100                 105                 110         


Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro Thr Glu Glu 
        115                 120                 125 


<210>  92
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-CAR-dTAG

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Gly Asn Pro Pro Pro Pro Glu Thr 
                485                 490                 495     


Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln Tyr Leu 
            500                 505                 510         


Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala Trp Pro 
        515                 520                 525             


Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp Tyr Tyr 
    530                 535                 540                 


Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys Arg Leu 
545                 550                 555                 560 


Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp Phe Asn 
                565                 570                 575     


Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp Asp Ile 
            580                 585                 590         


Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys Ile Asn 
        595                 600                 605             


Glu Leu Pro Thr Glu Glu Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr 
    610                 615                 620                 


Ala 
625 


<210>  93
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG derivative of MTH1

<400>  93

Gly Ala Ser Arg Leu Tyr Thr Leu Val Leu Val Leu Gln Pro Gln Arg 
1               5                   10                  15      


Val Leu Leu Gly Met Lys Lys Arg Gly Phe Gly Ala Gly Arg Trp Asn 
            20                  25                  30          


Gly Phe Gly Gly Lys Val Gln Glu Gly Glu Thr Ile Glu Asp Gly Ala 
        35                  40                  45              


Arg Arg Glu Leu Gln Glu Glu Ser Gly Leu Thr Val Asp Ala Leu His 
    50                  55                  60                  


Lys Val Gly Gln Ile Val Phe Glu Phe Val Gly Glu Pro Glu Leu Met 
65                  70                  75                  80  


Asp Val His Val Phe Cys Thr Asp Ser Ile Gln Gly Thr Pro Val Glu 
                85                  90                  95      


Ser Asp Glu Met Arg Pro Cys Trp Phe Gln Leu Asp Gln Ile Pro Phe 
            100                 105                 110         


Lys Asp Met Trp Pro Asp Asp Ser Tyr Trp Phe Pro Leu Leu Leu Gln 
        115                 120                 125             


Lys Lys Lys Phe His Gly Tyr Phe Lys Phe Gln Gly Gln Asp Thr Ile 
    130                 135                 140                 


Leu Asp Tyr Thr Leu Arg Glu Val Asp Thr 
145                 150                 


<210>  94
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19-CAR-dTAG

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Gly Gly Ala Ser Arg Leu Tyr Thr 
                485                 490                 495     


Leu Val Leu Val Leu Gln Pro Gln Arg Val Leu Leu Gly Met Lys Lys 
            500                 505                 510         


Arg Gly Phe Gly Ala Gly Arg Trp Asn Gly Phe Gly Gly Lys Val Gln 
        515                 520                 525             


Glu Gly Glu Thr Ile Glu Asp Gly Ala Arg Arg Glu Leu Gln Glu Glu 
    530                 535                 540                 


Ser Gly Leu Thr Val Asp Ala Leu His Lys Val Gly Gln Ile Val Phe 
545                 550                 555                 560 


Glu Phe Val Gly Glu Pro Glu Leu Met Asp Val His Val Phe Cys Thr 
                565                 570                 575     


Asp Ser Ile Gln Gly Thr Pro Val Glu Ser Asp Glu Met Arg Pro Cys 
            580                 585                 590         


Trp Phe Gln Leu Asp Gln Ile Pro Phe Lys Asp Met Trp Pro Asp Asp 
        595                 600                 605             


Ser Tyr Trp Phe Pro Leu Leu Leu Gln Lys Lys Lys Phe His Gly Tyr 
    610                 615                 620                 


Phe Lys Phe Gln Gly Gln Asp Thr Ile Leu Asp Tyr Thr Leu Arg Glu 
625                 630                 635                 640 


Val Asp Thr Val Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                645                 650                 655 


<210>  95
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG derived from BRD4

<400>  95

Asn Pro Pro Pro Pro Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln 
1               5                   10                  15      


Thr Asn Gln Leu Gln Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp 
            20                  25                  30          


Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys 
        35                  40                  45              


Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met 
    50                  55                  60                  


Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln 
65                  70                  75                  80  


Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr 
                85                  90                  95      


Asn Lys Pro Gly Asp Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys 
            100                 105                 110         


Leu Phe Leu Gln Lys Ile Asn Glu Leu Pro Thr Glu Glu 
        115                 120                 125 


<210>  96
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser Arg Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro Lys Lys 
1               5                   10                  15      


Lys Asn Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp Leu Ile 
            20                  25                  30          


Thr Ile Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val Glu Ala 
        35                  40                  45              


Phe Asp Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr 
    50                  55                  60                  


Gly Arg Lys Ser Pro Val Gly 
65                  70      


<210>  97
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  97

Ala Ile Asp Lys Arg Phe Arg Val Phe Thr Lys Pro Val Asp Pro Asp 
1               5                   10                  15      


Glu Val Pro Asp Tyr Val Thr Val Ile Lys Gln Pro Met Asp Leu Ser 
            20                  25                  30          


Ser Val Ile Ser Lys Ile Asp Leu His Lys Tyr Leu Thr Val Lys Asp 
        35                  40                  45              


Tyr Leu Arg Asp Ile Asp Leu Ile Cys Ser Asn Ala Leu Glu Tyr Asn 
    50                  55                  60                  


Pro Asp Arg Asp Pro Gly 
65                  70  


<210>  98
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  98

Val Arg His Asp Asp Ser Trp Pro Phe Leu Lys Leu Val Ser Lys Ile 
1               5                   10                  15      


Gln Val Pro Asp Tyr Tyr Asp Ile Ile Lys Lys Pro Ile Ala Leu Asn 
            20                  25                  30          


Ile Ile Arg Glu Lys Val Asn Lys Cys Glu Tyr Lys Leu Ala Ser Glu 
        35                  40                  45              


Phe Ile Asp Asp Ile Glu Leu Met Phe Ser Asn Cys Phe Glu Tyr Asn 
    50                  55                  60                  


Pro Arg Asn Thr Ser Glu Ala 
65                  70      


<210>  99
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  99

Val Lys Tyr Arg Phe Ser Trp Pro Phe Arg Glu Pro Val Thr Arg Asp 
1               5                   10                  15      


Glu Ala Glu Asp Tyr Tyr Asp Val Ile Thr His Pro Met Asp Phe Gln 
            20                  25                  30          


Thr Val Gln Asn Lys Cys Ser Cys Gly Ser Tyr Arg Ser Val Gln Glu 
        35                  40                  45              


Phe Leu Thr Asp Met Lys Gln Val Phe Thr Asn Ala Glu Val Tyr Asn 
    50                  55                  60                  


Cys Arg Gly Ser His Val Leu 
65                  70      


<210>  100
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  100

Glu Ser His Asp Ala Ala Trp Pro Phe Leu Glu Pro Val Asn Pro Arg 
1               5                   10                  15      


Leu Val Ser Gly Tyr Arg Arg Ile Ile Lys Asn Pro Met Asp Phe Ser 
            20                  25                  30          


Thr Met Arg Glu Arg Leu Leu Arg Gly Gly Tyr Thr Ser Ser Glu Glu 
        35                  40                  45              


Phe Ala Ala Asp Ala Leu Leu Val Phe Asp Asn Cys Gln Thr Phe Asn 
    50                  55                  60                  


Glu Asp Asp Ser Glu Val Gly 
65                  70      


<210>  101
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  101

Glu Thr His Glu Asp Ala Trp Pro Phe Leu Leu Pro Val Asn Leu Lys 
1               5                   10                  15      


Leu Val Pro Gly Tyr Lys Lys Val Ile Lys Lys Pro Met Asp Phe Ser 
            20                  25                  30          


Thr Ile Arg Glu Lys Leu Ser Ser Gly Gln Tyr Pro Asn Leu Glu Thr 
        35                  40                  45              


Phe Ala Leu Asp Val Arg Leu Val Phe Asp Asn Cys Glu Thr Phe Asn 
    50                  55                  60                  


Glu Asp Asp Ser Asp Ile Gly 
65                  70      


<210>  102
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  102

Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser Leu Lys 
1               5                   10                  15      


Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp Phe Ala 
            20                  25                  30          


Thr Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu His Glu 
        35                  40                  45              


Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys Tyr Asn 
    50                  55                  60                  


Ala Arg Asp Thr Val Phe Tyr 
65                  70      


<210>  103
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val Thr Asp Phe 
1               5                   10                  15      


Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe Ser 
            20                  25                  30          


Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser Ile Glu Glu 
        35                  40                  45              


Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met Ile Tyr Asn 
    50                  55                  60                  


Lys Pro Glu Thr Ile Tyr Tyr 
65                  70      


<210>  104
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  104

Ala Asn His Arg Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp 
1               5                   10                  15      


Ile Ala Pro Gly Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser 
            20                  25                  30          


Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu 
        35                  40                  45              


Phe Gln Arg Asp Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn 
    50                  55                  60                  


Ser Ser Asp His Asp Val Tyr 
65                  70      


<210>  105
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  105

Ala Ser His Arg Phe Ser Ser Pro Phe Leu Lys Pro Val Ser Glu Arg 
1               5                   10                  15      


Gln Ala Pro Gly Tyr Lys Asp Val Val Lys Arg Pro Met Asp Leu Thr 
            20                  25                  30          


Ser Leu Lys Arg Asn Leu Ser Lys Gly Arg Ile Arg Thr Met Ala Gln 
        35                  40                  45              


Phe Leu Arg Asp Leu Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn 
    50                  55                  60                  


Asp Ser Asp His His Val Tyr 
65                  70      


<210>  106
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  106

Gln Arg Lys Asp Pro His Gly Phe Phe Ala Phe Pro Val Thr Asp Ala 
1               5                   10                  15      


Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met Asp Phe Gly 
            20                  25                  30          


Thr Met Lys Asp Lys Ile Val Ala Asn Glu Tyr Lys Ser Val Thr Glu 
        35                  40                  45              


Phe Lys Ala Asp Phe Lys Leu Met Cys Asp Asn Ala Met Thr Tyr Asn 
    50                  55                  60                  


Arg Pro Asp Thr Val Tyr Tyr 
65                  70      


<210>  107
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  107

Trp Lys His Ser Phe Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val 
1               5                   10                  15      


Lys Leu Gln Leu Pro Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp 
            20                  25                  30          


Leu Asn Thr Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala 
        35                  40                  45              


Ser Glu Cys Ile Glu Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu 
    50                  55                  60                  


Tyr Asn Lys Pro Gly Asp Asp Ile Val 
65                  70              


<210>  108
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  108

Lys His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn 
1               5                   10                  15      


Ala Leu Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp 
            20                  25                  30          


Leu Gly Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala 
        35                  40                  45              


Tyr Lys Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Glu Val 
65                  70          


<210>  109
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  109

Gln Glu Lys Asp Thr Gly Asn Ile Phe Ser Glu Pro Val Pro Leu Ser 
1               5                   10                  15      


Glu Val Pro Asp Tyr Leu Asp His Ile Lys Lys Pro Met Asp Phe Phe 
            20                  25                  30          


Thr Met Lys Gln Asn Leu Glu Ala Tyr Arg Tyr Leu Asn Phe Asp Asp 
        35                  40                  45              


Phe Glu Glu Asp Phe Asn Leu Ile Val Ser Asn Cys Leu Lys Tyr Asn 
    50                  55                  60                  


Ala Lys Asp Thr Ile Phe Tyr 
65                  70      


<210>  110
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Glu Lys Asp Pro Ala His Ile Phe Ala Glu Pro Val Asn Leu Ser 
1               5                   10                  15      


Glu Val Pro Asp Tyr Leu Glu Phe Ile Ser Lys Pro Met Asp Phe Ser 
            20                  25                  30          


Thr Met Arg Arg Lys Leu Glu Ser His Leu Tyr Arg Thr Leu Glu Glu 
        35                  40                  45              


Phe Glu Glu Asp Phe Asn Leu Ile Val Thr Asn Cys Met Lys Tyr Asn 
    50                  55                  60                  


Ala Lys Asp Thr Ile Phe His 
65                  70      


<210>  111
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  111

Leu Ser Leu Asp Phe Ala Ser Pro Phe Ala Val Pro Val Asp Leu Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Tyr Cys Thr Val Val Ala Tyr Pro Thr Asp Leu Asn 
            20                  25                  30          


Thr Ile Arg Arg Arg Leu Glu Asn Arg Phe Tyr Arg Arg Ile Ser Ala 
        35                  40                  45              


Leu Met Trp Glu Val Arg Tyr Ile Glu His Asn Ala Arg Thr Phe Asn 
    50                  55                  60                  


Glu Pro Asp Ser Pro Ile Val 
65                  70      


<210>  112
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  112

Tyr Glu Arg Glu Asp Ser Glu Pro Phe Arg Gln Pro Ala Asp Leu Leu 
1               5                   10                  15      


Ser Tyr Pro Gly His Gln Glu Gln Glu Gly Glu Ser Ser Glu Ser Val 
            20                  25                  30          


Val Pro Glu Arg Gln Gln Asp Ser Ser Leu Ser Glu Asp Tyr Gln Asp 
        35                  40                  45              


Val Ile Asp Thr Pro Val Asp Phe Ser Thr Val Lys Glu Thr Leu Glu 
    50                  55                  60                  


Ala Gly Asn Tyr Gly Ser Pro Leu Glu Phe Tyr Lys Asp Val Arg Gln 
65                  70                  75                  80  


Ile Phe Asn Asn Ser Lys Ala Tyr Thr Ser Asn Lys Lys Ser Arg Ile 
                85                  90                  95      


<210>  113
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  113

Lys Ala His Lys Asp Ser Trp Pro Phe Leu Glu Pro Val Asp Glu Ser 
1               5                   10                  15      


Tyr Ala Pro Asn Tyr Tyr Gln Ile Ile Lys Ala Pro Met Asp Ile Ser 
            20                  25                  30          


Ser Met Glu Lys Lys Leu Asn Gly Gly Leu Tyr Cys Thr Lys Glu Glu 
        35                  40                  45              


Phe Val Asn Asp Met Lys Thr Met Phe Arg Asn Cys Arg Lys Tyr Asn 
    50                  55                  60                  


Gly Glu Ser Ser Glu Tyr Thr 
65                  70      


<210>  114
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG

<400>  114

Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Thr Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys 
            20                  25                  30          


Pro Gly Thr Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met 
        35                  40                  45              


Lys Lys Leu Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
    50                  55                  60                  


Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Gly Ser Lys Gly Ser Leu 
65                  70                  75                  80  


Leu Asp Phe Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln 
                85                  90                  95      


Leu Val Asp Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu 
            100                 105                 110         


Arg Met Asn Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Gly Glu Asn Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys 
            180                 185                 190         


Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln 
        195                 200                 205             


Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser 
    210                 215                 220                 


Leu His Asp Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe 
                245                 250                 


<210>  115
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dTAG

<400>  115

Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp 
1               5                   10                  15      


Met Gly Thr Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys 
            20                  25                  30          


Pro Gly Thr Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met 
        35                  40                  45              


Lys Lys Leu Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser 
    50                  55                  60                  


Glu Glu Pro Ile Tyr Ile Val Thr Glu Tyr Ala Ser Lys Gly Ser Leu 
65                  70                  75                  80  


Leu Asp Phe Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln 
                85                  90                  95      


Leu Val Asp Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu 
            100                 105                 110         


Arg Met Asn Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        115                 120                 125             


Gly Glu Asn Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu 
    130                 135                 140                 


Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile 
145                 150                 155                 160 


Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys 
                165                 170                 175     


Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys 
            180                 185                 190         


Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln 
        195                 200                 205             


Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser 
    210                 215                 220                 


Leu His Asp Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe 
                245                 250                 


