                         SEQUENCE LISTING

<110>  Medannex Ltd.
 
<120>  Specific Binding Molecules

<130>  42.18.131219/02

<150>  GB 1702091.8
<151>  2017-02-08

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  1

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  3

Leu Gln Val Thr His Val Pro Tyr Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  7

Lys Ala Ser Glu Asn Val Val Thr Tyr Val Ser 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  10
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  11
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  12
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Leu Ile Leu Arg Tyr Thr Phe Ser Lys Met Ala Met Val Ser 
1               5                   10                  15      


Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr 
            20                  25                  30          


Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser 
        35                  40                  45              


Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys 
    50                  55                  60                  


Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu 
                85                  90                  95      


Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr 
            100                 105                 110         


Gly His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln 
        115                 120                 125             


Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp 
    130                 135                 140                 


Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile 
145                 150                 155                 160 


Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala 
                165                 170                 175     


Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu 
            180                 185                 190         


Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly 
        195                 200                 


<210>  13
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro 
        115 


<210>  14
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  14

Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  15
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  15

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Leu Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  16
<211>  473
<212>  PRT
<213>  Mus musculus

<400>  16

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Ala Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Ile Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala 
            180                 185                 190         


Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu 
    370                 375                 380                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
385                 390                 395                 400 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                405                 410                 415     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            420                 425                 430         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        435                 440                 445             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    450                 455                 460                 


Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470             


<210>  17
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Combined sequence of Mdx001 CDRs

<400>  17

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


Gly Val Ser Asn Arg Phe Ser Leu Gln Val Thr His Val Pro Tyr Thr 
            20                  25                  30          


Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly Asp Ile Tyr Pro Gly Gly 
        35                  40                  45              


Asp Tyr Thr Asn Tyr Asn Glu Lys Phe Lys Gly Ala Arg Trp Gly Leu 
    50                  55                  60                  


Gly Tyr Tyr Phe Asp Tyr 
65                  70  


<210>  18
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  18

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ala Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  20
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VLCDR1 Sequence Codon-Optimised for Expression in Hamster

<400>  20
cggtcaagcc agagcttgga gaactcgaat ggaaagacct acctcaat                    48


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VLCDR2 Sequence Codon-Optimised for Expression in Hamster

<400>  21
ggggtgtcga acagattttc c                                                 21


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VLCDR3 Sequence Codon-Optimised for Expression in Hamster

<400>  22
cttcaggtca cccatgtgcc gtacacc                                           27


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VHCDR1 Sequence Codon-Optimised for Expression in Hamster

<400>  23
ggctacacct tcaccaacta ctggatcggc                                        30


<210>  24
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VLCDR2 Sequence Codon-Optimised for Expression in Hamster

<400>  24
gacatctatc cgggtggaga ctacaccaac tacaacgaaa agttcaaggg a                51


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 VHCDR3 Sequence Codon-Optimised for Expression in Hamster

<400>  25
gcccggtggg gacttggtta ctacttcgac tac                                    33


<210>  26
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  26
cagactccac tctccctgcc tgtcagtctt ggagatcaag tctccatctc ttgcaggtct       60

agtcagagcc ttgaaaacag taatggaaaa acctatttga actggtacct ccagaaacca      120

ggccagtctc cacagctcct gatctacggg gtttccaacc gattttctgg ggtcctagac      180

aggttcagtg gtagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      240

gaggatttgg gagtttattt ctgcctccaa gttacacatg tcccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  27
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  27
ccaggtccag ctgcagcagt ctggacctga actggtcagg cctgggactt cagtgaagat       60

gtcctgcaag gcttctggat acaccttcac taactactgg ataggttggg caaagcagag      120

gcctggacat ggccttgagt ggattggaga tatttaccct ggaggtgatt atactaacta      180

caatgagaag ttcaagggca aggccacact gactgcagac aaatcctcca gcacagccta      240

catgcagttc agcagcctga catctgagga ctctgccatc tattattgtg caagatgggg      300

gttaggatac tactttgact actggggcca aggcatcact ctcacagtct cctcagc         357


<210>  28
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 Light Chain Variable Region Codon-Optimised for Expression
       in Hamster

<400>  28
gacgctgtga tgacccagac tcctctgtcc ctgcccgtgt ccctggggga ccaagtctcc       60

atctcctgcc ggtcaagcca gagcttggag aactcgaatg gaaagaccta cctcaattgg      120

tacctccaga agccggggca gtccccccaa ctcctgatct acggggtgtc gaacagattt      180

tccggagtgc tggatcggtt ctcgggctcc ggaagcggca ccgacttcac tctgaaaatt      240

agccgcgtgg aagccgagga cttgggcgtg tatttctgcc ttcaggtcac ccatgtgccg      300

tacaccttcg gtggcggcac aaagctggaa atcaag                                336


<210>  29
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 Heavy Chain Variable Region Codon-Optimised for Expression
       in Hamster

<400>  29
caagtgcagc tgcagcagtc cggccccgaa ctcgtgcggc caggcacctc cgtgaagatg       60

tcctgcaaag cgtccggcta caccttcacc aactactgga tcggctgggc aaagcagagg      120

cccggacatg gcctcgaatg gattggcgac atctatccgg gtggagacta caccaactac      180

aacgaaaagt tcaagggaaa ggccaccctg accgctgata agtccagctc caccgcatac      240

atgcagttct cgtcactgac tagcgaagat tccgcgatct actactgcgc ccggtgggga      300

cttggttact acttcgacta ctggggacag ggaattaccc tgaccgtgtc cagc            354


<210>  30
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 Light Chain Codon-Optimised for Expression in Hamster

<400>  30
atggtgtcat ctgcacaatt tctgggactt cttctgctgt gtttccaagg aacccgctgt       60

gacgctgtga tgacccagac tcctctgtcc ctgcccgtgt ccctggggga ccaagtctcc      120

atctcctgcc ggtcaagcca gagcttggag aactcgaatg gaaagaccta cctcaattgg      180

tacctccaga agccggggca gtccccccaa ctcctgatct acggggtgtc gaacagattt      240

tccggagtgc tggatcggtt ctcgggctcc ggaagcggca ccgacttcac tctgaaaatt      300

agccgcgtgg aagccgagga cttgggcgtg tatttctgcc ttcaggtcac ccatgtgccg      360

tacaccttcg gtggcggcac aaagctggaa atcaagaggg cggacgcggc ccctaccgtg      420

tcaattttcc caccgagctc cgaacagctc accagcggcg gtgcctcggt cgtgtgcttc      480

ctcaacaact tctatccaaa agacattaac gtcaagtgga agatcgatgg atcggagaga      540

cagaacggag tgctgaacag ctggactgat caggactcca aggattcgac ctactccatg      600

agctccactc tgaccctgac caaggacgaa tacgagcggc acaattccta cacttgcgaa      660

gccacccaca agacctcaac gtcccccatc gtgaagtcct tcaaccgcaa cgagtgc         717


<210>  31
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mdx001 Heavy Chain Codon-Optimised for Expression in Hamster

<400>  31
atgggatgga ctctcgtgtt cctttttctc ctctctgtca ctgccggggt gcattcgcaa       60

gtgcagctgc agcagtccgg ccccgaactc gtgcggccag gcacctccgt gaagatgtcc      120

tgcaaagcgt ccggctacac cttcaccaac tactggatcg gctgggcaaa gcagaggccc      180

ggacatggcc tcgaatggat tggcgacatc tatccgggtg gagactacac caactacaac      240

gaaaagttca agggaaaggc caccctgacc gctgataagt ccagctccac cgcatacatg      300

cagttctcgt cactgactag cgaagattcc gcgatctact actgcgcccg gtggggactt      360

ggttactact tcgactactg gggacaggga attaccctga ccgtgtccag cgccaagact      420

acgccgccgt ccgtctaccc tttggccccc ggttgcggcg acaccaccgg ctcgtcagtg      480

actctgggct gcctcgtgaa ggggtacttc cccgagtccg tcaccgtcac ttggaacagc      540

ggcagccttt cgtcctcggt ccacaccttc cccgctctgc tgcaaagcgg tctgtacacc      600

atgtcctcat ccgtgaccgt gccctcctcc acttggccga gccagaccgt gacttgctcc      660

gtggcccacc cggcgtcctc gaccaccgtg gacaagaagc tggagccgtc aggtccaatc      720

tccaccatca atccctgccc gccttgtaaa gagtgccaca agtgccctgc ccccaatctg      780

gagggaggac cttcggtgtt cattttccct ccgaatatca aggacgtgtt gatgatctcc      840

ctgaccccga aggtcacatg cgtggtcgtc gacgtgtccg aggacgatcc ggacgtgcag      900

attagctggt tcgtgaacaa cgtggaagtg cacactgcgc agacccaaac ccatcgggag      960

gactataact ccactatccg cgtcgtgtca acactgccga tccagcacca ggactggatg     1020

agcggaaagg aattcaagtg taaagtcaac aacaaggatc tgccaagccc tatcgagcgc     1080

accattagca agatcaaggg actcgtgcgc gccccacaag tgtacattct cccccctccg     1140

gcggaacagc tgagcagaaa ggatgtgtcg ctgacgtgtt tggtcgtggg attcaacccc     1200

ggggatattt ccgtggaatg gacttcgaac gggcacaccg aagagaacta caaggacacc     1260

gcccctgtgc tggacagcga cggatcatac ttcatctatt cgaagctgaa catgaaaact     1320

tccaaatggg aaaagaccga ctcgttttcc tgtaacgtgc gccacgaagg actcaagaac     1380

tactacctga agaaaactat ctctcggtcc ccggggaagt ga                        1422


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised Light Chain Variable Region L1

<400>  32

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised Heavy Chain Variable Region H4

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised Light Chain Variable Region L2

<400>  34

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  35
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised Heavy Chain Variable Region H2

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 Variant 1

<400>  36

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 Variant 2

<400>  37

Arg Ser Ser Gln Ser Leu Glu Asn Thr Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  38
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Combined Sequence of CDRs of MDX-L1M2H4 & MDX-L2M2H2

<400>  38

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn 
1               5                   10                  15      


Gly Val Ser Asn Arg Phe Ser Leu Gln Val Thr His Val Pro Tyr Thr 
            20                  25                  30          


Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly Asp Ile Tyr Pro Gly Gly 
        35                  40                  45              


Asp Tyr Thr Asn Tyr Asn Glu Lys Phe Lys Gly Ala Arg Trp Gly Leu 
    50                  55                  60                  


Gly Tyr Tyr Phe Asp Tyr 
65                  70  


<210>  39
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Combined Sequence of CDRs of MDX-L1M3H4 & MDX-L2M3H2

<400>  39

Arg Ser Ser Gln Ser Leu Glu Asn Thr Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


Gly Val Ser Asn Arg Phe Ser Leu Gln Val Thr His Val Pro Tyr Thr 
            20                  25                  30          


Gly Tyr Thr Phe Thr Asn Tyr Trp Ile Gly Asp Ile Tyr Pro Gly Gly 
        35                  40                  45              


Asp Tyr Thr Asn Tyr Asn Glu Lys Phe Lys Gly Ala Arg Trp Gly Leu 
    50                  55                  60                  


Gly Tyr Tyr Phe Asp Tyr 
65                  70  


<210>  40
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Light Chain

<400>  40

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  41
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Heavy Chain

<400>  41

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  42
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Light Chain

<400>  42

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  43
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Heavy Chain

<400>  43

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  44
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 Light Chain

<400>  44

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  45
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 Light Chain

<400>  45

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Ser Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  46
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 Light Chain

<400>  46

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Thr Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  47
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 Light Chain

<400>  47

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Glu Asn Thr Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 Light Chain Variable Region

<400>  48

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 Light Chain Variable Region

<400>  49

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Thr 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 Light Chain Variable Region

<400>  50

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 Light Chain Variable Region

<400>  51

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Thr 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence of Humanised Light Chains

<400>  52

Met Val Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence of Humanised Heavy Chains

<400>  53

Met Gly Trp Thr Leu Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  54
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 Mature Light Chain

<400>  54

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  55
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Mature Heavy Chain

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLCDR1 "mod1"

<400>  56

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  57
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 Light Chain

<400>  57
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca      120

atttcatgcc ggtccagcca gtccctggag aactccaacg ccaagaccta tctgaactgg      180

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcaagagtgg aagccgagga cgtgggcgtg tacttctgcc tccaagtcac gcacgtgccg      360

tacactttcg gacaagggac taagctggag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  58
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Heavy Chain

<400>  58
atgggatgga ctctcgtgtt cctttttctc ctctctgtca ctgccggggt gcattcgcaa       60

gtccagctgg tgcagtcggg agcagaggtg aaaaagcccg gatcgtcagt gaaggtcagc      120

tgcaaagcct cgggatacac tttcaccaac tactggattg gatgggtcag acaggccccc      180

ggccaaggac tggagtgggt cggcgacatc taccctgggg gcgactatac caactacaac      240

gaaaagttca agggacgcgt gacaattacc gccgataaga gcaccagcac tgcctacatg      300

gagcttagct cattgcggtc cgaggatacc gctgtgtact actgtgcgcg gtggggcctt      360

ggttactact tcgactactg gggacagggt accatggtca cggtgtcctc cgcgtccacc      420

aagggtccct ccgtgttccc tctcgcgccg tcctcaaagt ctacctccgg tggaactgcc      480

gcgctcggtt gtctcgtgaa ggactacttc ccggagcctg tgactgtctc ctggaactcc      540

ggggccctca ccagcggagt gcacactttc cccgccgtgc tgcaatcctc cggcctgtac      600

agcctgtcct ccgtcgtgac tgtgcctagc tcctccctgg gaacccagac ctacatctgc      660

aacgtgaacc acaagccctc caacaccaag gtcgacaaga aggtcgaacc gaagtcgtgc      720

gacaagactc atacgtgccc tccttgcccg gccccggaac tgctgggagg cccatccgtg      780

ttcctgttcc cacccaagcc taaggatacc ctgatgatca gcagaacacc ggaagtgacc      840

tgtgtggtgg tggacgtcag ccacgaagat cccgaggtca agttcaattg gtacgtggac      900

ggggtggagg tgcacaacgc aaagaccaag ccccgggagg aacagtacaa ctccacctat      960

cgcgtggtgt cggtgctgac ggtgctgcac caggactggt tgaacggaaa ggagtataag     1020

tgcaaagtgt cgaacaaggc cctgcccgct cctatcgaaa agaccatctc caaggccaag     1080

ggccagccgc gggaacccca ggtctacact ctcccaccga gccgcgacga actgactaag     1140

aatcaagtgt cgctgacttg cctcgtcaag ggcttctacc cgtccgacat cgccgtggaa     1200

tgggagagca acggccagcc ggaaaacaac tacaagacca cccctcccgt gctggattcc     1260

gacgggtcct tcttcctgta ctcaaaactg accgtggata agtccagatg gcagcagggc     1320

aatgtctttt catgctccgt gatgcacgag gctctgcata accactacac ccagaagtcg     1380

ctgtccctgt ccccggggaa gtga                                            1404


<210>  59
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 Light Chain Variable Region

<400>  59
gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca       60

atttcatgcc ggtccagcca gtccctggag aactccaacg ccaagaccta tctgaactgg      120

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcaagagtgg aagccgagga cgtgggcgtg tacttctgcc tccaagtcac gcacgtgccg      300

tacactttcg gacaagggac taagctggag atcaag                                336


<210>  60
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Heavy Chain Variable Region

<400>  60
caagtccagc tggtgcagtc gggagcagag gtgaaaaagc ccggatcgtc agtgaaggtc       60

agctgcaaag cctcgggata cactttcacc aactactgga ttggatgggt cagacaggcc      120

cccggccaag gactggagtg ggtcggcgac atctaccctg ggggcgacta taccaactac      180

aacgaaaagt tcaagggacg cgtgacaatt accgccgata agagcaccag cactgcctac      240

atggagctta gctcattgcg gtccgaggat accgctgtgt actactgtgc gcggtggggc      300

cttggttact acttcgacta ctggggacag ggtaccatgg tcacggtgtc ctcc            354


<210>  61
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 Ligh Chain

<400>  61
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc      120

atttcctgcc gctcaagcca gtccctggag aactcaaacg ccaagaccta cctgaattgg      180

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      360

tacactttcg gacaagggac taaggtcgag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  62
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Heavy Chain

<400>  62
atgggatgga ctctcgtgtt cctttttctc ctctctgtca ctgccggggt gcattcgcaa       60

gtccagctgg tgcagtcggg accagaggtg aaaaagcccg gagagtcact taagatcagc      120

tgcaaaggct cgggatacac tttcaccaac tactggattg gttgggtcag acaggccccc      180

ggcaaaggac tggagtggat gggcgacatc taccctgggg gcgactatac caactacaac      240

gaaaagttca agggacaagt gacaatttcg gccgataaga gcattagcac tgcatacctt      300

cagtggagct cattgaaggc ctccgatacc gctatctact actgtgcgcg gtggggcctg      360

ggatactact tcgactactg gggaaggggt accttggtca cggtgtcctc cgcgtccacc      420

aagggtccct ccgtgttccc tctcgcgccg tcctcaaagt ctacctccgg tggaactgcc      480

gcgctcggtt gtctcgtgaa ggactacttc ccggagcctg tgactgtctc ctggaactcc      540

ggggccctca ccagcggagt gcacactttc cccgccgtgc tgcaatcctc cggcctgtac      600

agcctgtcct ccgtcgtgac tgtgcctagc tcctccctgg gaacccagac ctacatctgc      660

aacgtgaacc acaagccctc caacaccaag gtcgacaaga aggtcgaacc gaagtcgtgc      720

gacaagactc atacgtgccc tccttgcccg gccccggaac tgctgggagg cccatccgtg      780

ttcctgttcc cacccaagcc taaggatacc ctgatgatca gcagaacacc ggaagtgacc      840

tgtgtggtgg tggacgtcag ccacgaagat cccgaggtca agttcaattg gtacgtggac      900

ggggtggagg tgcacaacgc aaagaccaag ccccgggagg aacagtacaa ctccacctat      960

cgcgtggtgt cggtgctgac ggtgctgcac caggactggt tgaacggaaa ggagtataag     1020

tgcaaagtgt cgaacaaggc cctgcccgct cctatcgaaa agaccatctc caaggccaag     1080

ggccagccgc gggaacccca ggtctacact ctcccaccga gccgcgacga actgactaag     1140

aatcaagtgt cgctgacttg cctcgtcaag ggcttctacc cgtccgacat cgccgtggaa     1200

tgggagagca acggccagcc ggaaaacaac tacaagacca cccctcccgt gctggattcc     1260

gacgggtcct tcttcctgta ctcaaaactg accgtggata agtccagatg gcagcagggc     1320

aatgtctttt catgctccgt gatgcacgag gctctgcata accactacac ccagaagtcg     1380

ctgtccctgt ccccggggaa gtga                                            1404


<210>  63
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 Light Chain Variable Region

<400>  63
gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc       60

atttcctgcc gctcaagcca gtccctggag aactcaaacg ccaagaccta cctgaattgg      120

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      300

tacactttcg gacaagggac taaggtcgag atcaag                                336


<210>  64
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Heavy Chain Variable Region

<400>  64
caagtccagc tggtgcagtc gggaccagag gtgaaaaagc ccggagagtc acttaagatc       60

agctgcaaag gctcgggata cactttcacc aactactgga ttggttgggt cagacaggcc      120

cccggcaaag gactggagtg gatgggcgac atctaccctg ggggcgacta taccaactac      180

aacgaaaagt tcaagggaca agtgacaatt tcggccgata agagcattag cactgcatac      240

cttcagtgga gctcattgaa ggcctccgat accgctatct actactgtgc gcggtggggc      300

ctgggatact acttcgacta ctggggaagg ggtaccttgg tcacggtgtc ctcc            354


<210>  65
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M2H4 VLCDR1

<400>  65
cggtccagcc agtccctgga gaactccaac gccaagacct atctgaac                    48


<210>  66
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 VLCDR1

<400>  66
cgctcaagcc agtccctgga gaactcaaac gccaagacct acctgaat                    48


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 & MDX-L2H2 VLCDR2

<400>  67
ggcgtcagca acaggttctc g                                                 21


<210>  68
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 VLCDR3

<400>  68
ctccaagtca cgcacgtgcc gtacact                                           27


<210>  69
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 VLCDR3

<400>  69
ctccaagtca cccacgtgcc gtacact                                           27


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 VHCDR1

<400>  70
ggatacactt tcaccaacta ctggattgga                                        30


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 VHCDR1

<400>  71
ggatacactt tcaccaacta ctggattggt                                        30


<210>  72
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 & MDX-L2H2 VHCDR2

<400>  72
gacatctacc ctgggggcga ctataccaac tacaacgaaa agttcaaggg a                51


<210>  73
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 VHCDR3

<400>  73
gcgcggtggg gccttggtta ctacttcgac tac                                    33


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 VHCDR3

<400>  74
gcgcggtggg gcctgggata ctacttcgac tac                                    33


<210>  75
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Mature Light Chain

<400>  75

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  76
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 Mature Light Chain

<400>  76

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Thr 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  77
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Mature Light Chain

<400>  77

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  78
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M2H2 Mature Light Chain

<400>  78

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  79
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 Mature Light Chain

<400>  79

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Thr 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  80
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Mature Heavy Chain

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asp Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  81
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Light Chain

<400>  81
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca      120

atttcatgcc ggtccagcca gtccctggag aactccaacg gaaagaccta tctgaactgg      180

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcaagagtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac gcacgtgccg      360

tacactttcg gacaagggac taagctggag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  82
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 Light Chain Variable Region

<400>  82
gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca       60

atttcatgcc ggtccagcca gtccctggag aactccaacg gaaagaccta tctgaactgg      120

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcaagagtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac gcacgtgccg      300

tacactttcg gacaagggac taagctggag atcaag                                336


<210>  83
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Light Chain

<400>  83
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc      120

atttcctgcc gctcaagcca gtccctggag aactcaaacg gaaagaccta cctgaattgg      180

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      360

tacactttcg gacaagggac taaggtcgag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  84
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 Ligh Chain Variable Region

<400>  84
gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc       60

atttcctgcc gctcaagcca gtccctggag aactcaaacg gaaagaccta cctgaattgg      120

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      300

tacactttcg gacaagggac taaggtcgag atcaag                                336


<210>  85
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1H4 VLCDR1

<400>  85
cggtccagcc agtccctgga gaactccaac ggaaagacct atctgaac                    48


<210>  86
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2H2 VLCDR1

<400>  86
cgctcaagcc agtccctgga gaactcaaac ggaaagacct acctgaat                    48


<210>  87
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 VLCDR1

<400>  87
cggtccagcc agtccctgga gaacaccaac ggaaagacct atctgaac                    48


<210>  88
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 VLCDR1

<400>  88
cgctcaagcc agtccctgga gaacaccaac ggaaagacct acctgaat                    48


<210>  89
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 Light Chain

<400>  89
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca      120

atttcatgcc ggtccagcca gtccctggag aacaccaacg gaaagaccta tctgaactgg      180

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcaagagtgg aagccgagga cgtgggcgtg tacttctgcc tccaagtcac gcacgtgccg      360

tacactttcg gacaagggac taagctggag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  90
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L1M3H4 Light Chain Variable Region

<400>  90
gacgtggtca tgacccagag cccactgagc cttccggtca ccttgggaca gcccgcctca       60

atttcatgcc ggtccagcca gtccctggag aacaccaacg gaaagaccta tctgaactgg      120

ttccagcagc gccctggaca gtccccgagg cgcctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcaagagtgg aagccgagga cgtgggcgtg tacttctgcc tccaagtcac gcacgtgccg      300

tacactttcg gacaagggac taagctggag atcaag                                336


<210>  91
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 Light Chain

<400>  91
atggtgtcat ccgctcaatt tctcggtttg cttctcctgt gtttccaagg cacccgctgc       60

gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc      120

atttcctgcc gctcaagcca gtccctggag aacaccaacg gaaagaccta cctgaattgg      180

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      240

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      300

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      360

tacactttcg gacaagggac taaggtcgag atcaagcgga ccgtggcggc cccctctgtg      420

ttcattttcc ctccctcgga cgaacagctg aagtcgggaa cagcctccgt cgtgtgcctg      480

ctcaacaact tctacccccg ggaagcgaag gtccagtgga aagtggataa cgcactccaa      540

tcggggaact cccaggaatc cgtgactgag caggactcga aggattccac ttactccctg      600

tcgtccaccc tgactctgag caaggccgac tacgagaagc ataaggtcta cgcctgcgaa      660

gtgacccacc agggtctgag ctcccctgtg accaagagct ttaatcgggg cgaatgttga      720


<210>  92
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MDX-L2M3H2 Light Chain Variable Region

<400>  92
gacatcgtca tgacccagac cccattgagc ctttccgtca cgccgggaca gcccgcctcc       60

atttcctgcc gctcaagcca gtccctggag aacaccaacg gaaagaccta cctgaattgg      120

tatctgcaga agcctggaca gagcccgcag ctgctgatct acggcgtcag caacaggttc      180

tcgggcgtgc cggacagatt ctccggctcc ggaagcggaa ctgacttcac cctgaaaatc      240

tcacgcgtgg aagccgagga cgtgggcgtg tactactgcc tccaagtcac ccacgtgccg      300

tacactttcg gacaagggac taaggtcgag atcaag                                336


