                         SEQUENCE LISTING

<110>  UNIVERSITE LAVAL
       CICCHETTI, Francesca
       BOILARD, Eric
 
<120>  ERYTHROCYTE-DERIVED EXTRACELLULAR VESICLES AND PROTEINS 
       ASSOCIATED WITH SUCH VESICLES AS BIOMARKERS FOR PARKINSON'S 
       DISEASE

<130>  000819-0350

<140>  To be assigned
<141>  2018-02-08

<150>  US 62/457,350
<151>  2017-02-10

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  AIDA

<400>  1

Met Ser Glu Val Thr Arg Ser Leu Leu Gln Arg Trp Gly Ala Ser Phe 
1               5                   10                  15      


Arg Arg Gly Ala Asp Phe Asp Ser Trp Gly Gln Leu Val Glu Ala Ile 
            20                  25                  30          


Asp Glu Tyr Gln Ile Leu Ala Arg His Leu Gln Lys Glu Ala Gln Ala 
        35                  40                  45              


Gln His Asn Asn Ser Glu Phe Thr Glu Glu Gln Lys Lys Thr Ile Gly 
    50                  55                  60                  


Lys Ile Ala Thr Cys Leu Glu Leu Arg Ser Ala Ala Leu Gln Ser Thr 
65                  70                  75                  80  


Gln Ser Gln Glu Glu Phe Lys Leu Glu Asp Leu Lys Lys Leu Glu Pro 
                85                  90                  95      


Ile Leu Lys Asn Ile Leu Thr Tyr Asn Lys Glu Phe Pro Phe Asp Val 
            100                 105                 110         


Gln Pro Val Pro Leu Arg Arg Ile Leu Ala Pro Gly Glu Glu Glu Asn 
        115                 120                 125             


Leu Glu Phe Glu Glu Asp Glu Glu Glu Gly Gly Ala Gly Ala Gly Ser 
    130                 135                 140                 


Pro Asp Ser Phe Pro Ala Arg Val Pro Gly Thr Leu Leu Pro Arg Leu 
145                 150                 155                 160 


Pro Ser Glu Pro Gly Met Thr Leu Leu Thr Ile Arg Ile Glu Lys Ile 
                165                 170                 175     


Gly Leu Lys Asp Ala Gly Gln Cys Ile Asp Pro Tyr Ile Thr Val Ser 
            180                 185                 190         


Val Lys Asp Leu Asn Gly Ile Asp Leu Thr Pro Val Gln Asp Thr Pro 
        195                 200                 205             


Val Ala Ser Arg Lys Glu Asp Thr Tyr Val His Phe Asn Val Asp Ile 
    210                 215                 220                 


Glu Leu Gln Lys His Val Glu Lys Leu Thr Lys Gly Ala Ala Ile Phe 
225                 230                 235                 240 


Phe Glu Phe Lys His Tyr Lys Pro Lys Lys Arg Phe Thr Ser Thr Lys 
                245                 250                 255     


Cys Phe Ala Phe Met Glu Met Asp Glu Ile Lys Pro Gly Pro Ile Val 
            260                 265                 270         


Ile Glu Leu Tyr Lys Lys Pro Thr Asp Phe Lys Arg Lys Lys Leu Gln 
        275                 280                 285             


Leu Leu Thr Lys Lys Pro Leu Tyr Leu His Leu His Gln Thr Leu His 
    290                 295                 300                 


Lys Glu 
305     


<210>  2
<211>  210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ABHD14B

<400>  2

Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


<210>  3
<211>  446
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NADSYN1

<400>  3

Met Gly Ile Ser Gly Gln Glu Val Leu Thr Ala Thr Leu Asp Leu Glu 
1               5                   10                  15      


Asp Val Arg Ser Tyr Arg Ala Glu Ile Ser Ser Arg Asn Leu Ala Ala 
            20                  25                  30          


Ser Arg Ala Ser Pro Tyr Pro Arg Val Lys Val Asp Phe Ala Leu Ser 
        35                  40                  45              


Cys His Glu Asp Leu Leu Ala Pro Ile Ser Glu Pro Ile Glu Trp Lys 
    50                  55                  60                  


Tyr His Ser Pro Glu Glu Glu Ile Ser Leu Gly Pro Ala Cys Trp Leu 
65                  70                  75                  80  


Trp Asp Phe Leu Arg Arg Ser Gln Gln Ala Gly Phe Leu Leu Pro Leu 
                85                  90                  95      


Ser Gly Gly Val Asp Ser Ala Ala Thr Ala Cys Leu Ile Tyr Ser Met 
            100                 105                 110         


Cys Cys Gln Val Cys Glu Ala Val Arg Ser Gly Asn Glu Glu Val Leu 
        115                 120                 125             


Ala Asp Val Arg Thr Ile Val Asn Gln Ile Ser Tyr Thr Pro Gln Asp 
    130                 135                 140                 


Pro Arg Asp Leu Cys Gly Arg Ile Leu Thr Thr Cys Tyr Met Ala Ser 
145                 150                 155                 160 


Lys Asn Ser Ser Gln Glu Thr Cys Thr Arg Ala Arg Glu Leu Ala Gln 
                165                 170                 175     


Gln Ile Gly Ser His His Ile Ser Leu Asn Ile Asp Pro Ala Val Lys 
            180                 185                 190         


Ala Val Met Gly Ile Phe Ser Leu Val Thr Gly Lys Ser Pro Leu Phe 
        195                 200                 205             


Ala Ala His Gly Gly Ser Ser Arg Glu Asn Leu Ala Leu Gln Asn Val 
    210                 215                 220                 


Gln Ala Arg Ile Arg Met Val Leu Ala Tyr Leu Phe Ala Gln Leu Ser 
225                 230                 235                 240 


Leu Trp Ser Arg Gly Val His Gly Gly Leu Leu Val Leu Gly Ser Ala 
                245                 250                 255     


Asn Val Asp Glu Ser Leu Leu Gly Tyr Leu Thr Lys Tyr Asp Cys Ser 
            260                 265                 270         


Ser Ala Asp Ile Asn Pro Ile Gly Gly Ile Ser Lys Thr Asp Leu Arg 
        275                 280                 285             


Ala Phe Val Gln Phe Cys Ile Gln Arg Phe Gln Leu Pro Ala Leu Gln 
    290                 295                 300                 


Ser Ile Leu Leu Ala Pro Ala Thr Ala Glu Leu Glu Pro Leu Ala Asp 
305                 310                 315                 320 


Gly Gln Val Ser Gln Thr Asp Glu Glu Asp Met Gly Met Thr Tyr Ala 
                325                 330                 335     


Glu Leu Ser Val Tyr Gly Lys Leu Arg Lys Val Ala Lys Met Gly Pro 
            340                 345                 350         


Tyr Ser Met Phe Cys Lys Leu Leu Gly Met Trp Arg His Ile Cys Thr 
        355                 360                 365             


Pro Arg Gln Val Ala Asp Lys Val Lys Arg Phe Phe Ser Lys Tyr Ser 
    370                 375                 380                 


Met Asn Arg His Lys Met Thr Thr Leu Thr Pro Ala Tyr His Ala Glu 
385                 390                 395                 400 


Asn Tyr Ser Pro Glu Asp Asn Arg Phe Asp Leu Arg Pro Phe Leu Tyr 
                405                 410                 415     


Asn Thr Ser Trp Pro Trp Gln Phe Arg Cys Ile Glu Asn Gln Val Leu 
            420                 425                 430         


Gln Leu Glu Arg Ala Glu Pro Gln Ser Leu Asp Gly Val Asp 
        435                 440                 445     


<210>  4
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  QDPR

<400>  4

Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr 
1               5                   10                  15      


Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala 
            20                  25                  30          


Arg Asn Trp Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys 
        35                  40                  45              


Val Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala 
    50                  55                  60                  


Lys Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser 
65                  70                  75                  80  


Ile Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys 
                85                  90                  95      


Glu Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly 
            100                 105                 110         


Thr Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln 
        115                 120                 125             


Leu Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala 
    130                 135                 140                 


Ala Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg 
145                 150                 155                 160 


Lys Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe 
                165                 170                 175     


Leu Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser 
            180                 185                 190         


Ser Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu 
        195                 200                 205             


Thr Pro Ala Tyr Phe 
    210             


<210>  5
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  AKR1A1

<400>  5

Met Ala Ala Ser Cys Val Leu Leu His Thr Gly Gln Lys Met Pro Leu 
1               5                   10                  15      


Ile Gly Leu Gly Thr Trp Lys Ser Glu Pro Gly Gln Val Lys Ala Ala 
            20                  25                  30          


Val Lys Tyr Ala Leu Ser Val Gly Tyr Arg His Ile Asp Cys Ala Ala 
        35                  40                  45              


Ile Tyr Gly Asn Glu Pro Glu Ile Gly Glu Ala Leu Lys Glu Asp Val 
    50                  55                  60                  


Gly Pro Gly Lys Ala Val Pro Arg Glu Glu Leu Phe Val Thr Ser Lys 
65                  70                  75                  80  


Leu Trp Asn Thr Lys His His Pro Glu Asp Val Glu Pro Ala Leu Arg 
                85                  90                  95      


Lys Thr Leu Ala Asp Leu Gln Leu Glu Tyr Leu Asp Leu Tyr Leu Met 
            100                 105                 110         


His Trp Pro Tyr Ala Phe Glu Arg Gly Asp Asn Pro Phe Pro Lys Asn 
        115                 120                 125             


Ala Asp Gly Thr Ile Cys Tyr Asp Ser Thr His Tyr Lys Glu Thr Trp 
    130                 135                 140                 


Lys Ala Leu Glu Ala Leu Val Ala Lys Gly Leu Val Gln Ala Leu Gly 
145                 150                 155                 160 


Leu Ser Asn Phe Asn Ser Arg Gln Ile Asp Asp Ile Leu Ser Val Ala 
                165                 170                 175     


Ser Val Arg Pro Ala Val Leu Gln Val Glu Cys His Pro Tyr Leu Ala 
            180                 185                 190         


Gln Asn Glu Leu Ile Ala His Cys Gln Ala Arg Gly Leu Glu Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Ser Asp Arg Ala Trp Arg Asp Pro Asp 
    210                 215                 220                 


Glu Pro Val Leu Leu Glu Glu Pro Val Val Leu Ala Leu Ala Glu Lys 
225                 230                 235                 240 


Tyr Gly Arg Ser Pro Ala Gln Ile Leu Leu Arg Trp Gln Val Gln Arg 
                245                 250                 255     


Lys Val Ile Cys Ile Pro Lys Ser Ile Thr Pro Ser Arg Ile Leu Gln 
            260                 265                 270         


Asn Ile Lys Val Phe Asp Phe Thr Phe Ser Pro Glu Glu Met Lys Gln 
        275                 280                 285             


Leu Asn Ala Leu Asn Lys Asn Trp Arg Tyr Ile Val Pro Met Leu Thr 
    290                 295                 300                 


Val Asp Gly Lys Arg Val Pro Arg Asp Ala Gly His Pro Leu Tyr Pro 
305                 310                 315                 320 


Phe Asn Asp Pro Tyr 
                325 


<210>  6
<211>  137
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CNRIP1

<400>  6

Met Gly Asp Leu Pro Gly Leu Val Arg Leu Ser Ile Ala Leu Arg Ile 
1               5                   10                  15      


Gln Pro Asn Asp Gly Pro Val Phe Tyr Lys Val Asp Gly Gln Arg Phe 
            20                  25                  30          


Gly Gln Asn Arg Thr Ile Lys Leu Leu Thr Gly Ser Ser Tyr Lys Val 
        35                  40                  45              


Glu Val Lys Ile Lys Pro Ser Thr Leu Gln Val Glu Asn Ile Ser Ile 
    50                  55                  60                  


Gly Gly Val Leu Val Pro Leu Glu Leu Lys Ser Lys Glu Pro Asp Gly 
65                  70                  75                  80  


Asp Arg Val Val Tyr Thr Gly Thr Tyr Asp Thr Glu Gly Val Thr Pro 
                85                  90                  95      


Thr Lys Ser Gly Glu Arg Gln Pro Ile Gln Ile Thr Met Pro Val Arg 
            100                 105                 110         


Leu Ala Cys Gly Tyr Arg Ser Met Val Pro Trp Lys Met Glu Thr Thr 
        115                 120                 125             


Glu Lys Lys Thr Ile Thr Ile Ser Leu 
    130                 135         


<210>  7
<211>  2620
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  USP24

<400>  7

Met Glu Ser Glu Glu Glu Gln His Met Thr Thr Leu Leu Cys Met Gly 
1               5                   10                  15      


Phe Ser Asp Pro Ala Thr Ile Arg Lys Ala Leu Arg Leu Ala Lys Asn 
            20                  25                  30          


Asp Ile Asn Glu Ala Val Ala Leu Leu Thr Asn Glu Arg Pro Gly Leu 
        35                  40                  45              


Asp Tyr Gly Gly Tyr Glu Pro Met Asp Ser Gly Gly Gly Pro Ser Pro 
    50                  55                  60                  


Gly Pro Gly Gly Gly Pro Arg Gly Asp Gly Gly Gly Asp Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Pro Ser Arg Gly Gly Ser Thr Gly Gly Gly Gly Gly Phe Asp 
                85                  90                  95      


Pro Pro Pro Ala Tyr His Glu Val Val Asp Ala Glu Lys Asn Asp Glu 
            100                 105                 110         


Asn Gly Asn Cys Ser Gly Glu Gly Ile Glu Phe Pro Thr Thr Asn Leu 
        115                 120                 125             


Tyr Glu Leu Glu Ser Arg Val Leu Thr Asp His Trp Ser Ile Pro Tyr 
    130                 135                 140                 


Lys Arg Glu Glu Ser Leu Gly Lys Cys Leu Leu Ala Ser Thr Tyr Leu 
145                 150                 155                 160 


Ala Arg Leu Gly Leu Ser Glu Ser Asp Glu Asn Cys Arg Arg Phe Met 
                165                 170                 175     


Asp Arg Cys Met Pro Glu Ala Phe Lys Lys Leu Leu Thr Ser Ser Ala 
            180                 185                 190         


Val His Lys Trp Gly Thr Glu Ile His Glu Gly Ile Tyr Asn Met Leu 
        195                 200                 205             


Met Leu Leu Ile Glu Leu Val Ala Glu Arg Ile Lys Gln Asp Pro Ile 
    210                 215                 220                 


Pro Thr Gly Leu Leu Gly Val Leu Thr Met Ala Phe Asn Pro Asp Asn 
225                 230                 235                 240 


Glu Tyr His Phe Lys Asn Arg Met Lys Val Ser Gln Arg Asn Trp Ala 
                245                 250                 255     


Glu Val Phe Gly Glu Gly Asn Met Phe Ala Val Ser Pro Val Ser Thr 
            260                 265                 270         


Phe Gln Lys Glu Pro His Gly Trp Val Val Asp Leu Val Asn Lys Phe 
        275                 280                 285             


Gly Glu Leu Gly Gly Phe Ala Ala Ile Gln Ala Lys Leu His Ser Glu 
    290                 295                 300                 


Asp Ile Glu Leu Gly Ala Val Ser Ala Leu Ile Gln Pro Leu Gly Val 
305                 310                 315                 320 


Cys Ala Glu Tyr Leu Asn Ser Ser Val Val Gln Pro Met Leu Asp Pro 
                325                 330                 335     


Val Ile Leu Thr Thr Ile Gln Asp Val Arg Ser Val Glu Glu Lys Asp 
            340                 345                 350         


Leu Lys Asp Lys Arg Leu Val Ser Ile Pro Glu Leu Leu Ser Ala Val 
        355                 360                 365             


Lys Leu Leu Cys Met Arg Phe Gln Pro Asp Leu Val Thr Ile Val Asp 
    370                 375                 380                 


Asp Leu Arg Leu Asp Ile Leu Leu Arg Met Leu Lys Ser Pro His Phe 
385                 390                 395                 400 


Ser Ala Lys Met Asn Ser Leu Lys Glu Val Thr Lys Leu Ile Glu Asp 
                405                 410                 415     


Ser Thr Leu Ser Lys Ser Val Lys Asn Ala Ile Asp Thr Asp Arg Leu 
            420                 425                 430         


Leu Asp Trp Leu Val Glu Asn Ser Val Leu Ser Ile Ala Leu Glu Gly 
        435                 440                 445             


Asn Ile Asp Gln Ala Gln Tyr Cys Asp Arg Ile Lys Gly Ile Ile Glu 
    450                 455                 460                 


Leu Leu Gly Ser Lys Leu Ser Leu Asp Glu Leu Thr Lys Ile Trp Lys 
465                 470                 475                 480 


Ile Gln Ser Gly Gln Ser Ser Thr Val Ile Glu Asn Ile His Thr Ile 
                485                 490                 495     


Ile Ala Ala Ala Ala Val Lys Phe Asn Ser Asp Gln Leu Asn His Leu 
            500                 505                 510         


Phe Val Leu Ile Gln Lys Ser Trp Glu Thr Glu Ser Asp Arg Val Arg 
        515                 520                 525             


Gln Lys Leu Leu Ser Leu Ile Gly Arg Ile Gly Arg Glu Ala Arg Phe 
    530                 535                 540                 


Glu Thr Thr Ser Gly Lys Val Leu Asp Val Leu Trp Glu Leu Ala His 
545                 550                 555                 560 


Leu Pro Thr Leu Pro Ser Ser Leu Ile Gln Gln Ala Leu Glu Glu His 
                565                 570                 575     


Leu Thr Ile Leu Ser Asp Ala Tyr Ala Val Lys Glu Ala Ile Lys Arg 
            580                 585                 590         


Ser Tyr Ile Ile Lys Cys Ile Glu Asp Ile Lys Arg Pro Gly Glu Trp 
        595                 600                 605             


Ser Gly Leu Glu Lys Asn Lys Lys Asp Gly Phe Lys Ser Ser Gln Leu 
    610                 615                 620                 


Asn Asn Pro Gln Phe Val Trp Val Val Pro Ala Leu Arg Gln Leu His 
625                 630                 635                 640 


Glu Ile Thr Arg Ser Phe Ile Lys Gln Thr Tyr Gln Lys Gln Asp Lys 
                645                 650                 655     


Ser Ile Ile Gln Asp Leu Lys Lys Asn Phe Glu Ile Val Lys Leu Val 
            660                 665                 670         


Thr Gly Ser Leu Ile Ala Cys His Arg Leu Ala Ala Ala Val Ala Gly 
        675                 680                 685             


Pro Gly Gly Leu Ser Gly Ser Thr Leu Val Asp Gly Arg Tyr Thr Tyr 
    690                 695                 700                 


Arg Glu Tyr Leu Glu Ala His Leu Lys Phe Leu Ala Phe Phe Leu Gln 
705                 710                 715                 720 


Glu Ala Thr Leu Tyr Leu Gly Trp Asn Arg Ala Lys Glu Ile Trp Glu 
                725                 730                 735     


Cys Leu Val Thr Gly Gln Asp Val Cys Glu Leu Asp Arg Glu Met Cys 
            740                 745                 750         


Phe Glu Trp Phe Thr Lys Gly Gln His Asp Leu Glu Ser Asp Val Gln 
        755                 760                 765             


Gln Gln Leu Phe Lys Glu Lys Ile Leu Lys Leu Glu Ser Tyr Glu Ile 
    770                 775                 780                 


Thr Met Asn Gly Phe Asn Leu Phe Lys Thr Phe Phe Glu Asn Val Asn 
785                 790                 795                 800 


Leu Cys Asp His Arg Leu Lys Arg Gln Gly Ala Gln Leu Tyr Val Glu 
                805                 810                 815     


Lys Leu Glu Leu Ile Gly Met Asp Phe Ile Trp Lys Ile Ala Met Glu 
            820                 825                 830         


Ser Pro Asp Glu Glu Ile Ala Asn Glu Ala Ile Gln Leu Ile Ile Asn 
        835                 840                 845             


Tyr Ser Tyr Ile Asn Leu Asn Pro Arg Leu Lys Lys Asp Ser Val Ser 
    850                 855                 860                 


Leu His Lys Lys Phe Ile Ala Asp Cys Tyr Thr Arg Leu Glu Ala Ala 
865                 870                 875                 880 


Ser Ser Ala Leu Gly Gly Pro Thr Leu Thr His Ala Val Thr Arg Ala 
                885                 890                 895     


Thr Lys Met Leu Thr Ala Thr Ala Met Pro Thr Val Ala Thr Ser Val 
            900                 905                 910         


Gln Ser Pro Tyr Arg Ser Thr Lys Leu Val Ile Ile Glu Arg Leu Leu 
        915                 920                 925             


Leu Leu Ala Glu Arg Tyr Val Ile Thr Ile Glu Asp Phe Tyr Ser Val 
    930                 935                 940                 


Pro Arg Thr Ile Leu Pro His Gly Ala Ser Phe His Gly His Leu Leu 
945                 950                 955                 960 


Thr Leu Asn Val Thr Tyr Glu Ser Thr Lys Asp Thr Phe Thr Val Glu 
                965                 970                 975     


Ala His Ser Asn Glu Thr Ile Gly Ser Val Arg Trp Lys Ile Ala Lys 
            980                 985                 990         


Gln Leu Cys Ser Pro Val Asp Asn  Ile Gln Ile Phe Thr  Asn Asp Ser 
        995                 1000                 1005             


Leu Leu  Thr Val Asn Lys Asp  Gln Lys Leu Leu His  Gln Leu Gly 
    1010                 1015                 1020             


Phe Ser  Asp Glu Gln Ile Leu  Thr Val Lys Thr Ser  Gly Ser Gly 
    1025                 1030                 1035             


Thr Pro  Ser Gly Ser Ser Ala  Asp Ser Ser Thr Ser  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ser  Ser Gly Val Phe Ser  Ser Ser Tyr Ala Met  Glu Gln Glu 
    1055                 1060                 1065             


Lys Ser  Leu Pro Gly Val Val  Met Ala Leu Val Cys  Asn Val Phe 
    1070                 1075                 1080             


Asp Met  Leu Tyr Gln Leu Ala  Asn Leu Glu Glu Pro  Arg Ile Thr 
    1085                 1090                 1095             


Leu Arg  Val Arg Lys Leu Leu  Leu Leu Ile Pro Thr  Asp Pro Ala 
    1100                 1105                 1110             


Ile Gln  Glu Ala Leu Asp Gln  Leu Asp Ser Leu Gly  Arg Lys Lys 
    1115                 1120                 1125             


Thr Leu  Leu Ser Glu Ser Ser  Ser Gln Ser Ser Lys  Ser Pro Ser 
    1130                 1135                 1140             


Leu Ser  Ser Lys Gln Gln His  Gln Pro Ser Ala Ser  Ser Ile Leu 
    1145                 1150                 1155             


Glu Ser  Leu Phe Arg Ser Phe  Ala Pro Gly Met Ser  Thr Phe Arg 
    1160                 1165                 1170             


Val Leu  Tyr Asn Leu Glu Val  Leu Ser Ser Lys Leu  Met Pro Thr 
    1175                 1180                 1185             


Ala Asp  Asp Asp Met Ala Arg  Ser Cys Ala Lys Ser  Phe Cys Glu 
    1190                 1195                 1200             


Asn Phe  Leu Lys Ala Gly Gly  Leu Ser Leu Val Val  Asn Val Met 
    1205                 1210                 1215             


Gln Arg  Asp Ser Ile Pro Ser  Glu Val Asp Tyr Glu  Thr Arg Gln 
    1220                 1225                 1230             


Gly Val  Tyr Ser Ile Cys Leu  Gln Leu Ala Arg Phe  Leu Leu Val 
    1235                 1240                 1245             


Gly Gln  Thr Met Pro Thr Leu  Leu Asp Glu Asp Leu  Thr Lys Asp 
    1250                 1255                 1260             


Gly Ile  Glu Ala Leu Ser Ser  Arg Pro Phe Arg Asn  Val Ser Arg 
    1265                 1270                 1275             


Gln Thr  Ser Arg Gln Met Ser  Leu Cys Gly Thr Pro  Glu Lys Ser 
    1280                 1285                 1290             


Ser Tyr  Arg Gln Leu Ser Val  Ser Asp Arg Ser Ser  Ile Arg Val 
    1295                 1300                 1305             


Glu Glu  Ile Ile Pro Ala Ala  Arg Val Ala Ile Gln  Thr Met Glu 
    1310                 1315                 1320             


Val Ser  Asp Phe Thr Ser Thr  Val Ala Cys Phe Met  Arg Leu Ser 
    1325                 1330                 1335             


Trp Ala  Ala Ala Ala Gly Arg  Leu Asp Leu Val Gly  Ser Ser Gln 
    1340                 1345                 1350             


Pro Ile  Lys Glu Ser Asn Ser  Leu Cys Pro Ala Gly  Ile Arg Asn 
    1355                 1360                 1365             


Arg Leu  Ser Ser Ser Gly Ser  Asn Cys Ser Ser Gly  Ser Glu Gly 
    1370                 1375                 1380             


Glu Pro  Val Ala Leu His Ala  Gly Ile Cys Val Arg  Gln Gln Ser 
    1385                 1390                 1395             


Val Ser  Thr Lys Asp Ser Leu  Ile Ala Gly Glu Ala  Leu Ser Leu 
    1400                 1405                 1410             


Leu Val  Thr Cys Leu Gln Leu  Arg Ser Gln Gln Leu  Ala Ser Phe 
    1415                 1420                 1425             


Tyr Asn  Leu Pro Cys Val Ala  Asp Phe Ile Ile Asp  Ile Leu Leu 
    1430                 1435                 1440             


Gly Ser  Pro Ser Ala Glu Ile  Arg Arg Val Ala Cys  Asp Gln Leu 
    1445                 1450                 1455             


Tyr Thr  Leu Ser Gln Thr Asp  Thr Ser Ala His Pro  Asp Val Gln 
    1460                 1465                 1470             


Lys Pro  Asn Gln Phe Leu Leu  Gly Val Ile Leu Thr  Ala Gln Leu 
    1475                 1480                 1485             


Pro Leu  Trp Ser Pro Thr Ser  Ile Met Arg Gly Val  Asn Gln Arg 
    1490                 1495                 1500             


Leu Leu  Ser Gln Cys Met Glu  Tyr Phe Asp Leu Arg  Cys Gln Leu 
    1505                 1510                 1515             


Leu Asp  Asp Leu Thr Thr Ser  Glu Met Glu Gln Leu  Arg Ile Ser 
    1520                 1525                 1530             


Pro Ala  Thr Met Leu Glu Asp  Glu Ile Thr Trp Leu  Asp Asn Phe 
    1535                 1540                 1545             


Glu Pro  Asn Arg Thr Ala Glu  Cys Glu Thr Ser Glu  Ala Asp Asn 
    1550                 1555                 1560             


Ile Leu  Leu Ala Gly His Leu  Arg Leu Ile Lys Thr  Leu Leu Ser 
    1565                 1570                 1575             


Leu Cys  Gly Ala Glu Lys Glu  Met Leu Gly Ser Ser  Leu Ile Lys 
    1580                 1585                 1590             


Pro Leu  Leu Asp Asp Phe Leu  Phe Arg Ala Ser Arg  Ile Ile Leu 
    1595                 1600                 1605             


Asn Ser  His Ser Pro Ala Gly  Ser Ala Ala Ile Ser  Gln Gln Asp 
    1610                 1615                 1620             


Phe His  Pro Lys Cys Ser Thr  Ala Asn Ser Arg Leu  Ala Ala Tyr 
    1625                 1630                 1635             


Glu Val  Leu Val Met Leu Ala  Asp Ser Ser Pro Ser  Asn Leu Gln 
    1640                 1645                 1650             


Ile Ile  Ile Lys Glu Leu Leu  Ser Met His His Gln  Pro Asp Pro 
    1655                 1660                 1665             


Ala Leu  Thr Lys Glu Phe Asp  Tyr Leu Pro Pro Val  Asp Ser Arg 
    1670                 1675                 1680             


Ser Ser  Ser Gly Phe Val Gly  Leu Arg Asn Gly Gly  Ala Thr Cys 
    1685                 1690                 1695             


Tyr Met  Asn Ala Val Phe Gln  Gln Leu Tyr Met Gln  Pro Gly Leu 
    1700                 1705                 1710             


Pro Glu  Ser Leu Leu Ser Val  Asp Asp Asp Thr Asp  Asn Pro Asp 
    1715                 1720                 1725             


Asp Ser  Val Phe Tyr Gln Val  Gln Ser Leu Phe Gly  His Leu Met 
    1730                 1735                 1740             


Glu Ser  Lys Leu Gln Tyr Tyr  Val Pro Glu Asn Phe  Trp Lys Ile 
    1745                 1750                 1755             


Phe Lys  Met Trp Asn Lys Glu  Leu Tyr Val Arg Glu  Gln Gln Asp 
    1760                 1765                 1770             


Ala Tyr  Glu Phe Phe Thr Ser  Leu Ile Asp Gln Met  Asp Glu Tyr 
    1775                 1780                 1785             


Leu Lys  Lys Met Gly Arg Asp  Gln Ile Phe Lys Asn  Thr Phe Gln 
    1790                 1795                 1800             


Gly Ile  Tyr Ser Asp Gln Lys  Ile Cys Lys Asp Cys  Pro His Arg 
    1805                 1810                 1815             


Tyr Glu  Arg Glu Glu Ala Phe  Met Ala Leu Asn Leu  Gly Val Thr 
    1820                 1825                 1830             


Ser Cys  Gln Ser Leu Glu Ile  Ser Leu Asp Gln Phe  Val Arg Gly 
    1835                 1840                 1845             


Glu Val  Leu Glu Gly Ser Asn  Ala Tyr Tyr Cys Glu  Lys Cys Lys 
    1850                 1855                 1860             


Glu Lys  Arg Ile Thr Val Lys  Arg Thr Cys Ile Lys  Ser Leu Pro 
    1865                 1870                 1875             


Ser Val  Leu Val Ile His Leu  Met Arg Phe Gly Phe  Asp Trp Glu 
    1880                 1885                 1890             


Ser Gly  Arg Ser Ile Lys Tyr  Asp Glu Gln Ile Arg  Phe Pro Trp 
    1895                 1900                 1905             


Met Leu  Asn Met Glu Pro Tyr  Thr Val Ser Gly Met  Ala Arg Gln 
    1910                 1915                 1920             


Asp Ser  Ser Ser Glu Val Gly  Glu Asn Gly Arg Ser  Val Asp Gln 
    1925                 1930                 1935             


Gly Gly  Gly Gly Ser Pro Arg  Lys Lys Val Ala Leu  Thr Glu Asn 
    1940                 1945                 1950             


Tyr Glu  Leu Val Gly Val Ile  Val His Ser Gly Gln  Ala His Ala 
    1955                 1960                 1965             


Gly His  Tyr Tyr Ser Phe Ile  Lys Asp Arg Arg Gly  Cys Gly Lys 
    1970                 1975                 1980             


Gly Lys  Trp Tyr Lys Phe Asn  Asp Thr Val Ile Glu  Glu Phe Asp 
    1985                 1990                 1995             


Leu Asn  Asp Glu Thr Leu Glu  Tyr Glu Cys Phe Gly  Gly Glu Tyr 
    2000                 2005                 2010             


Arg Pro  Lys Val Tyr Asp Gln  Thr Asn Pro Tyr Thr  Asp Val Arg 
    2015                 2020                 2025             


Arg Arg  Tyr Trp Asn Ala Tyr  Met Leu Phe Tyr Gln  Arg Val Ser 
    2030                 2035                 2040             


Asp Gln  Asn Ser Pro Val Leu  Pro Lys Lys Ser Arg  Val Ser Val 
    2045                 2050                 2055             


Val Arg  Gln Glu Ala Glu Asp  Leu Ser Leu Ser Ala  Pro Ser Ser 
    2060                 2065                 2070             


Pro Glu  Ile Ser Pro Gln Ser  Ser Pro Arg Pro His  Arg Pro Asn 
    2075                 2080                 2085             


Asn Asp  Arg Leu Ser Ile Leu  Thr Lys Leu Val Lys  Lys Gly Glu 
    2090                 2095                 2100             


Lys Lys  Gly Leu Phe Val Glu  Lys Met Pro Ala Arg  Ile Tyr Gln 
    2105                 2110                 2115             


Met Val  Arg Asp Glu Asn Leu  Lys Phe Met Lys Asn  Arg Asp Val 
    2120                 2125                 2130             


Tyr Ser  Ser Asp Tyr Phe Ser  Phe Val Leu Ser Leu  Ala Ser Leu 
    2135                 2140                 2145             


Asn Ala  Thr Lys Leu Lys His  Pro Tyr Tyr Pro Cys  Met Ala Lys 
    2150                 2155                 2160             


Val Ser  Leu Gln Leu Ala Ile  Gln Phe Leu Phe Gln  Thr Tyr Leu 
    2165                 2170                 2175             


Arg Thr  Lys Lys Lys Leu Arg  Val Asp Thr Glu Glu  Trp Ile Ala 
    2180                 2185                 2190             


Thr Ile  Glu Ala Leu Leu Ser  Lys Ser Phe Asp Ala  Cys Gln Trp 
    2195                 2200                 2205             


Leu Val  Glu Tyr Phe Ile Ser  Ser Glu Gly Arg Glu  Leu Ile Lys 
    2210                 2215                 2220             


Ile Phe  Leu Leu Glu Cys Asn  Val Arg Glu Val Arg  Val Ala Val 
    2225                 2230                 2235             


Ala Thr  Ile Leu Glu Lys Thr  Leu Asp Ser Ala Leu  Phe Tyr Gln 
    2240                 2245                 2250             


Asp Lys  Leu Lys Ser Leu His  Gln Leu Leu Glu Val  Leu Leu Ala 
    2255                 2260                 2265             


Leu Leu  Asp Lys Asp Val Pro  Glu Asn Cys Lys Asn  Cys Ala Gln 
    2270                 2275                 2280             


Tyr Phe  Phe Leu Phe Asn Thr  Phe Val Gln Lys Gln  Gly Ile Arg 
    2285                 2290                 2295             


Ala Gly  Asp Leu Leu Leu Arg  His Ser Ala Leu Arg  His Met Ile 
    2300                 2305                 2310             


Ser Phe  Leu Leu Gly Ala Ser  Arg Gln Asn Asn Gln  Ile Arg Arg 
    2315                 2320                 2325             


Trp Ser  Ser Ala Gln Ala Arg  Glu Phe Gly Asn Leu  His Asn Thr 
    2330                 2335                 2340             


Val Ala  Leu Leu Val Leu His  Ser Asp Val Ser Ser  Gln Arg Asn 
    2345                 2350                 2355             


Val Ala  Pro Gly Ile Phe Lys  Gln Arg Pro Pro Ile  Ser Ile Ala 
    2360                 2365                 2370             


Pro Ser  Ser Pro Leu Leu Pro  Leu His Glu Glu Val  Glu Ala Leu 
    2375                 2380                 2385             


Leu Phe  Met Ser Glu Gly Lys  Pro Tyr Leu Leu Glu  Val Met Phe 
    2390                 2395                 2400             


Ala Leu  Arg Glu Leu Thr Gly  Ser Leu Leu Ala Leu  Ile Glu Met 
    2405                 2410                 2415             


Val Val  Tyr Cys Cys Phe Cys  Asn Glu His Phe Ser  Phe Thr Met 
    2420                 2425                 2430             


Leu His  Phe Ile Lys Asn Gln  Leu Glu Thr Ala Pro  Pro His Glu 
    2435                 2440                 2445             


Leu Lys  Asn Thr Phe Gln Leu  Leu His Glu Ile Leu  Val Ile Glu 
    2450                 2455                 2460             


Asp Pro  Ile Gln Val Glu Arg  Val Lys Phe Val Phe  Glu Thr Glu 
    2465                 2470                 2475             


Asn Gly  Leu Leu Ala Leu Met  His His Ser Asn His  Val Asp Ser 
    2480                 2485                 2490             


Ser Arg  Cys Tyr Gln Cys Val  Lys Phe Leu Val Thr  Leu Ala Gln 
    2495                 2500                 2505             


Lys Cys  Pro Ala Ala Lys Glu  Tyr Phe Lys Glu Asn  Ser His His 
    2510                 2515                 2520             


Trp Ser  Trp Ala Val Gln Trp  Leu Gln Lys Lys Met  Ser Glu His 
    2525                 2530                 2535             


Tyr Trp  Thr Pro Gln Ser Asn  Val Ser Asn Glu Thr  Ser Thr Gly 
    2540                 2545                 2550             


Lys Thr  Phe Gln Arg Thr Ile  Ser Ala Gln Asp Thr  Leu Ala Tyr 
    2555                 2560                 2565             


Ala Thr  Ala Leu Leu Asn Glu  Lys Glu Gln Ser Gly  Ser Ser Asn 
    2570                 2575                 2580             


Gly Ser  Glu Ser Ser Pro Ala  Asn Glu Asn Gly Asp  Arg His Leu 
    2585                 2590                 2595             


Gln Gln  Gly Ser Glu Ser Pro  Met Met Ile Gly Glu  Leu Arg Ser 
    2600                 2605                 2610             


Asp Leu  Asp Asp Val Asp Pro  
    2615                 2620 


<210>  8
<211>  221
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ATP5A1

<400>  8

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Asn Thr Gly Trp 
    210                 215                 220     


