                         SEQUENCE LISTING

<110>  University of Maryland
 
<120>  INFECTIOUS BRONCHITIS VIRUS VACCINE USING NEWCASTLE DISEASE VIRAL
        VECTOR

<130>  070919.00069

<150>  62/455,290
<151>  2017-02-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  54
<212>  DNA
<213>  Newcastle Disease Virus

<400>  1
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catg             54


<210>  2
<211>  11
<212>  DNA
<213>  Newcastle Disease Virus

<400>  2
taagtttaaa c                                                            11


<210>  3
<211>  5
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  3

Arg Arg Phe Arg Arg 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  4

Arg Arg Phe Arg Arg Ser 
1               5       


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
gaccagccgc taacctgaat                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
gtcctccgtc tgaaaaccgt                                                   20


<210>  7
<211>  15
<212>  DNA
<213>  Newcastle Disease Virus

<400>  7
tagctacatt taaga                                                        15


<210>  8
<211>  11
<212>  DNA
<213>  Newcastle Disease Virus

<400>  8
ttaagaaaaa a                                                            11


<210>  9
<211>  10
<212>  DNA
<213>  Newcastle Disease Virus

<400>  9
acgggtagaa                                                              10


<210>  10
<211>  1162
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  10

Met Leu Val Thr Pro Leu Leu Leu Val Thr Leu Leu Cys Val Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Tyr Asp Ser Ser Ser Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Pro Asn Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Ile Ser Ser Glu Ser Asn Asn Ala Gly Ser Ser Pro Gly 
    50                  55                  60                  


Cys Ile Val Gly Thr Ile His Gly Gly Arg Val Val Asn Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Met Thr Ala Pro Ser Ser Gly Met Ala Trp Ser Ser Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Thr Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Tyr Asp Gly Cys Pro Ile Thr Gly Met Leu Gln Lys 
        115                 120                 125             


Asn Phe Leu Arg Val Ser Ala Met Lys Asn Gly Gln Leu Phe Tyr Asn 
    130                 135                 140                 


Leu Thr Val Ser Val Ala Lys Tyr Pro Thr Phe Lys Ser Phe Gln Cys 
145                 150                 155                 160 


Val Asn Asn Leu Thr Ser Val Tyr Leu Asn Gly Asp Leu Val Tyr Thr 
                165                 170                 175     


Ser Asn Glu Thr Thr Asp Val Thr Ser Ala Gly Val Tyr Phe Lys Ala 
            180                 185                 190         


Gly Gly Pro Ile Thr Tyr Lys Val Met Arg Glu Val Lys Ala Leu Ala 
        195                 200                 205             


Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys Asp Gly Ser 
    210                 215                 220                 


Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe Ser Asp 
225                 230                 235                 240 


Gly Phe Tyr Pro Phe Ile Asn Ser Ser Leu Val Lys Gln Lys Phe Ile 
                245                 250                 255     


Val Tyr Arg Glu Asn Ser Val Asn Thr Thr Phe Thr Leu His Asn Phe 
            260                 265                 270         


Thr Phe His Asn Glu Thr Gly Ala Asn Pro Asn Pro Ser Gly Val Gln 
        275                 280                 285             


Asn Ile Gln Thr Tyr Gln Thr Gln Thr Ala Gln Ser Gly Tyr Tyr Asn 
    290                 295                 300                 


Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Glu Ser Asn Phe 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr His Pro Ser Cys Asn Phe Arg Leu Glu Thr Ile 
                325                 330                 335     


Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Ile Ala Tyr Gly 
            340                 345                 350         


Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly Arg Ala Thr 
        355                 360                 365             


Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro Ser Leu Cys Lys Gly Val 
    370                 375                 380                 


Tyr Ser Gly Glu Leu Asp Leu Asn Phe Glu Cys Gly Leu Leu Val Tyr 
385                 390                 395                 400 


Val Thr Lys Ser Gly Gly Ser Arg Ile Gln Thr Ala Thr Glu Pro Pro 
                405                 410                 415     


Val Ile Thr Arg His Asn Tyr Asn Asn Ile Thr Leu Asn Thr Cys Val 
            420                 425                 430         


Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Gln Gly Phe Ile Thr Asn Val 
        435                 440                 445             


Thr Asp Ser Ala Val Ser Tyr Asn Tyr Leu Ala Asp Ala Gly Leu Ala 
    450                 455                 460                 


Ile Leu Asp Thr Ser Gly Ser Ile Asp Ile Phe Val Val Gln Gly Glu 
465                 470                 475                 480 


Tyr Gly Leu Thr Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val Asn Gln 
                485                 490                 495     


Gln Phe Val Val Ser Gly Gly Lys Leu Val Gly Ile Leu Thr Ser Arg 
            500                 505                 510         


Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn Gln Phe Tyr Ile Lys Ile 
        515                 520                 525             


Thr Asn Gly Thr Arg Arg Phe Arg Arg Ser Ile Thr Glu Asn Val Ala 
    530                 535                 540                 


Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe Cys Ile Lys Pro Asp Gly 
545                 550                 555                 560 


Ser Ile Ala Thr Ile Val Pro Lys Gln Leu Glu Gln Phe Val Ala Pro 
                565                 570                 575     


Leu Leu Asn Val Thr Glu Asn Val Leu Ile Pro Asn Ser Phe Asn Leu 
            580                 585                 590         


Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg Met Asp Lys Val Gln Ile 
        595                 600                 605             


Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser Leu Asp Cys Arg Asp Leu 
    610                 615                 620                 


Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn Ile Leu Ser Val Val Asn 
625                 630                 635                 640 


Ser Ile Gly Gln Lys Glu Asp Met Glu Leu Leu Asn Phe Tyr Ser Ser 
                645                 650                 655     


Thr Lys Pro Ala Gly Phe Asn Thr Pro Phe Leu Ser Asn Val Ser Thr 
            660                 665                 670         


Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr Thr Pro Ser Ser Pro Arg 
        675                 680                 685             


Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe Thr Ser Val Glu Ser Val 
    690                 695                 700                 


Gly Leu Pro Thr Asp Asp Ala Tyr Lys Asn Cys Thr Ala Gly Pro Leu 
705                 710                 715                 720 


Gly Phe Leu Lys Asp Leu Ala Cys Ala Arg Glu Tyr Asn Gly Leu Leu 
                725                 730                 735     


Val Leu Pro Pro Ile Ile Thr Ala Glu Met Gln Thr Leu Tyr Thr Ser 
            740                 745                 750         


Ser Leu Val Ala Ser Met Ala Phe Gly Gly Ile Thr Ala Ala Gly Ala 
        755                 760                 765             


Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg Ile Asn His Leu Gly Ile 
    770                 775                 780                 


Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu Lys Ile Ala Ala Ser Phe 
785                 790                 795                 800 


Asn Lys Ala Ile Gly Arg Met Gln Glu Gly Phe Arg Ser Thr Ser Leu 
                805                 810                 815     


Ala Leu Gln Gln Ile Gln Asp Val Val Asn Lys Gln Ser Ala Ile Leu 
            820                 825                 830         


Thr Glu Thr Met Ala Ser Leu Asn Lys Asn Phe Gly Ala Ile Ser Ser 
        835                 840                 845             


Val Ile Gln Glu Ile Tyr Gln Gln Leu Asp Ala Ile Gln Ala Asn Ala 
    850                 855                 860                 


Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ser Ser Leu Ser Val Leu 
865                 870                 875                 880 


Ala Ser Ala Lys Gln Ala Glu His Ile Arg Val Ser Gln Gln Arg Glu 
                885                 890                 895     


Leu Ala Thr Gln Lys Ile Asn Glu Cys Val Lys Ser Gln Ser Ile Arg 
            900                 905                 910         


Tyr Ser Phe Cys Gly Asn Gly Arg His Val Leu Thr Ile Pro Gln Asn 
        915                 920                 925             


Ala Pro Asn Gly Ile Val Phe Ile His Phe Ser Tyr Thr Pro Asp Ser 
    930                 935                 940                 


Phe Val Asn Val Thr Ala Ile Val Gly Phe Cys Val Lys Pro Ala Asn 
945                 950                 955                 960 


Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn Gly Arg Gly Ile Phe Ile 
                965                 970                 975     


Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala Arg Asp Met Tyr Met Pro 
            980                 985                 990         


Arg Ala Ile Thr Ala Gly Asp Ile  Val Thr Leu Thr Ser  Cys Gln Ala 
        995                 1000                 1005             


Asn Tyr  Val Ser Val Asn Lys  Thr Val Ile Thr Thr  Phe Val Asp 
    1010                 1015                 1020             


Asn Asp  Asp Phe Asp Phe Asn  Asp Glu Leu Ser Lys  Trp Trp Asn 
    1025                 1030                 1035             


Asp Thr  Lys His Glu Leu Pro  Asp Phe Asp Lys Phe  Asn Tyr Thr 
    1040                 1045                 1050             


Val Pro  Ile Leu Asp Ile Asp  Ser Glu Ile Asp Arg  Ile Gln Gly 
    1055                 1060                 1065             


Val Ile  Gln Gly Leu Asn Asp  Ser Leu Ile Asp Leu  Glu Lys Leu 
    1070                 1075                 1080             


Ser Ile  Leu Lys Thr Tyr Ile  Lys Trp Pro Trp Tyr  Val Trp Leu 
    1085                 1090                 1095             


Ala Ile  Ala Phe Ala Thr Ile  Ile Phe Ile Leu Ile  Leu Gly Trp 
    1100                 1105                 1110             


Val Phe  Phe Met Thr Gly Cys  Cys Gly Cys Cys Cys  Gly Cys Phe 
    1115                 1120                 1125             


Gly Ile  Met Pro Leu Met Ser  Lys Cys Gly Lys Lys  Ser Ser Tyr 
    1130                 1135                 1140             


Tyr Thr  Thr Phe Asp Asn Asp  Val Val Thr Glu Gln  Asn Arg Pro 
    1145                 1150                 1155             


Lys Lys  Ser Val 
    1160         


<210>  11
<211>  532
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  11

Met Leu Val Thr Pro Leu Leu Leu Val Thr Leu Leu Cys Val Leu Cys 
1               5                   10                  15      


Ser Ala Ala Leu Tyr Asp Ser Ser Ser Tyr Val Tyr Tyr Tyr Gln Ser 
            20                  25                  30          


Ala Phe Arg Pro Pro Asn Gly Trp His Leu His Gly Gly Ala Tyr Ala 
        35                  40                  45              


Val Val Asn Ile Ser Ser Glu Ser Asn Asn Ala Gly Ser Ser Pro Gly 
    50                  55                  60                  


Cys Ile Val Gly Thr Ile His Gly Gly Arg Val Val Asn Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Met Thr Ala Pro Ser Ser Gly Met Ala Trp Ser Ser Ser Gln 
                85                  90                  95      


Phe Cys Thr Ala His Cys Asn Phe Ser Asp Thr Thr Val Phe Val Thr 
            100                 105                 110         


His Cys Tyr Lys Tyr Asp Gly Cys Pro Ile Thr Gly Met Leu Gln Lys 
        115                 120                 125             


Asn Phe Leu Arg Val Ser Ala Met Lys Asn Gly Gln Leu Phe Tyr Asn 
    130                 135                 140                 


Leu Thr Val Ser Val Ala Lys Tyr Pro Thr Phe Lys Ser Phe Gln Cys 
145                 150                 155                 160 


Val Asn Asn Leu Thr Ser Val Tyr Leu Asn Gly Asp Leu Val Tyr Thr 
                165                 170                 175     


Ser Asn Glu Thr Thr Asp Val Thr Ser Ala Gly Val Tyr Phe Lys Ala 
            180                 185                 190         


Gly Gly Pro Ile Thr Tyr Lys Val Met Arg Glu Val Lys Ala Leu Ala 
        195                 200                 205             


Tyr Phe Val Asn Gly Thr Ala Gln Asp Val Ile Leu Cys Asp Gly Ser 
    210                 215                 220                 


Pro Arg Gly Leu Leu Ala Cys Gln Tyr Asn Thr Gly Asn Phe Ser Asp 
225                 230                 235                 240 


Gly Phe Tyr Pro Phe Ile Asn Ser Ser Leu Val Lys Gln Lys Phe Ile 
                245                 250                 255     


Val Tyr Arg Glu Asn Ser Val Asn Thr Thr Phe Thr Leu His Asn Phe 
            260                 265                 270         


Thr Phe His Asn Glu Thr Gly Ala Asn Pro Asn Pro Ser Gly Val Gln 
        275                 280                 285             


Asn Ile Gln Thr Tyr Gln Thr Gln Thr Ala Gln Ser Gly Tyr Tyr Asn 
    290                 295                 300                 


Phe Asn Phe Ser Phe Leu Ser Ser Phe Val Tyr Lys Glu Ser Asn Phe 
305                 310                 315                 320 


Met Tyr Gly Ser Tyr His Pro Ser Cys Asn Phe Arg Leu Glu Thr Ile 
                325                 330                 335     


Asn Asn Gly Leu Trp Phe Asn Ser Leu Ser Val Ser Ile Ala Tyr Gly 
            340                 345                 350         


Pro Leu Gln Gly Gly Cys Lys Gln Ser Val Phe Ser Gly Arg Ala Thr 
        355                 360                 365             


Cys Cys Tyr Ala Tyr Ser Tyr Gly Gly Pro Ser Leu Cys Lys Gly Val 
    370                 375                 380                 


Tyr Ser Gly Glu Leu Asp Leu Asn Phe Glu Cys Gly Leu Leu Val Tyr 
385                 390                 395                 400 


Val Thr Lys Ser Gly Gly Ser Arg Ile Gln Thr Ala Thr Glu Pro Pro 
                405                 410                 415     


Val Ile Thr Arg His Asn Tyr Asn Asn Ile Thr Leu Asn Thr Cys Val 
            420                 425                 430         


Asp Tyr Asn Ile Tyr Gly Arg Thr Gly Gln Gly Phe Ile Thr Asn Val 
        435                 440                 445             


Thr Asp Ser Ala Val Ser Tyr Asn Tyr Leu Ala Asp Ala Gly Leu Ala 
    450                 455                 460                 


Ile Leu Asp Thr Ser Gly Ser Ile Asp Ile Phe Val Val Gln Gly Glu 
465                 470                 475                 480 


Tyr Gly Leu Thr Tyr Tyr Lys Val Asn Pro Cys Glu Asp Val Asn Gln 
                485                 490                 495     


Gln Phe Val Val Ser Gly Gly Lys Leu Val Gly Ile Leu Thr Ser Arg 
            500                 505                 510         


Asn Glu Thr Gly Ser Gln Leu Leu Glu Asn Gln Phe Tyr Ile Lys Ile 
        515                 520                 525             


Thr Asn Gly Thr 
    530         


<210>  12
<211>  6
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  12

Arg Arg Phe Arg Arg Ser 
1               5       


<210>  13
<211>  624
<212>  PRT
<213>  Infectious Bronchitis Virus

<400>  13

Ile Thr Glu Asn Val Ala Asn Cys Pro Tyr Val Ser Tyr Gly Lys Phe 
1               5                   10                  15      


Cys Ile Lys Pro Asp Gly Ser Ile Ala Thr Ile Val Pro Lys Gln Leu 
            20                  25                  30          


Glu Gln Phe Val Ala Pro Leu Leu Asn Val Thr Glu Asn Val Leu Ile 
        35                  40                  45              


Pro Asn Ser Phe Asn Leu Thr Val Thr Asp Glu Tyr Ile Gln Thr Arg 
    50                  55                  60                  


Met Asp Lys Val Gln Ile Asn Cys Leu Gln Tyr Val Cys Gly Asn Ser 
65                  70                  75                  80  


Leu Asp Cys Arg Asp Leu Phe Gln Gln Tyr Gly Pro Val Cys Asp Asn 
                85                  90                  95      


Ile Leu Ser Val Val Asn Ser Ile Gly Gln Lys Glu Asp Met Glu Leu 
            100                 105                 110         


Leu Asn Phe Tyr Ser Ser Thr Lys Pro Ala Gly Phe Asn Thr Pro Phe 
        115                 120                 125             


Leu Ser Asn Val Ser Thr Gly Glu Phe Asn Ile Ser Leu Leu Leu Thr 
    130                 135                 140                 


Thr Pro Ser Ser Pro Arg Arg Arg Ser Phe Ile Glu Asp Leu Leu Phe 
145                 150                 155                 160 


Thr Ser Val Glu Ser Val Gly Leu Pro Thr Asp Asp Ala Tyr Lys Asn 
                165                 170                 175     


Cys Thr Ala Gly Pro Leu Gly Phe Leu Lys Asp Leu Ala Cys Ala Arg 
            180                 185                 190         


Glu Tyr Asn Gly Leu Leu Val Leu Pro Pro Ile Ile Thr Ala Glu Met 
        195                 200                 205             


Gln Thr Leu Tyr Thr Ser Ser Leu Val Ala Ser Met Ala Phe Gly Gly 
    210                 215                 220                 


Ile Thr Ala Ala Gly Ala Ile Pro Phe Ala Thr Gln Leu Gln Ala Arg 
225                 230                 235                 240 


Ile Asn His Leu Gly Ile Thr Gln Ser Leu Leu Leu Lys Asn Gln Glu 
                245                 250                 255     


Lys Ile Ala Ala Ser Phe Asn Lys Ala Ile Gly Arg Met Gln Glu Gly 
            260                 265                 270         


Phe Arg Ser Thr Ser Leu Ala Leu Gln Gln Ile Gln Asp Val Val Asn 
        275                 280                 285             


Lys Gln Ser Ala Ile Leu Thr Glu Thr Met Ala Ser Leu Asn Lys Asn 
    290                 295                 300                 


Phe Gly Ala Ile Ser Ser Val Ile Gln Glu Ile Tyr Gln Gln Leu Asp 
305                 310                 315                 320 


Ala Ile Gln Ala Asn Ala Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 
                325                 330                 335     


Ser Ser Leu Ser Val Leu Ala Ser Ala Lys Gln Ala Glu His Ile Arg 
            340                 345                 350         


Val Ser Gln Gln Arg Glu Leu Ala Thr Gln Lys Ile Asn Glu Cys Val 
        355                 360                 365             


Lys Ser Gln Ser Ile Arg Tyr Ser Phe Cys Gly Asn Gly Arg His Val 
    370                 375                 380                 


Leu Thr Ile Pro Gln Asn Ala Pro Asn Gly Ile Val Phe Ile His Phe 
385                 390                 395                 400 


Ser Tyr Thr Pro Asp Ser Phe Val Asn Val Thr Ala Ile Val Gly Phe 
                405                 410                 415     


Cys Val Lys Pro Ala Asn Ala Ser Gln Tyr Ala Ile Val Pro Ala Asn 
            420                 425                 430         


Gly Arg Gly Ile Phe Ile Gln Val Asn Gly Ser Tyr Tyr Ile Thr Ala 
        435                 440                 445             


Arg Asp Met Tyr Met Pro Arg Ala Ile Thr Ala Gly Asp Ile Val Thr 
    450                 455                 460                 


Leu Thr Ser Cys Gln Ala Asn Tyr Val Ser Val Asn Lys Thr Val Ile 
465                 470                 475                 480 


Thr Thr Phe Val Asp Asn Asp Asp Phe Asp Phe Asn Asp Glu Leu Ser 
                485                 490                 495     


Lys Trp Trp Asn Asp Thr Lys His Glu Leu Pro Asp Phe Asp Lys Phe 
            500                 505                 510         


Asn Tyr Thr Val Pro Ile Leu Asp Ile Asp Ser Glu Ile Asp Arg Ile 
        515                 520                 525             


Gln Gly Val Ile Gln Gly Leu Asn Asp Ser Leu Ile Asp Leu Glu Lys 
    530                 535                 540                 


Leu Ser Ile Leu Lys Thr Tyr Ile Lys Trp Pro Trp Tyr Val Trp Leu 
545                 550                 555                 560 


Ala Ile Ala Phe Ala Thr Ile Ile Phe Ile Leu Ile Leu Gly Trp Val 
                565                 570                 575     


Phe Phe Met Thr Gly Cys Cys Gly Cys Cys Cys Gly Cys Phe Gly Ile 
            580                 585                 590         


Met Pro Leu Met Ser Lys Cys Gly Lys Lys Ser Ser Tyr Tyr Thr Thr 
        595                 600                 605             


Phe Asp Asn Asp Val Val Thr Glu Gln Asn Arg Pro Lys Lys Ser Val 
    610                 615                 620                 


<210>  14
<211>  3548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  14
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catgctggtg       60

actccactgc tgctggtgac tctgctgtgc gtgctgtgtt ccgccgccct gtacgattca      120

tcatcatacg tgtactatta ccagtccgct tttaggcccc ctaatggatg gcacctgcac      180

ggcggagctt acgcagtggt gaatatcagc tccgagagca acaatgctgg aagctcccct      240

ggatgcattg tgggaactat tcacggcggc agagtggtga acgctagctc cattgccatg      300

accgctccaa gctccggaat ggcctggagc tccagccagt tctgcacagc tcactgcaat      360

tttagcgata ccacagtgtt cgtgacccac tgctacaagt acgacggctg cccaatcaca      420

ggaatgctgc agaagaactt tctgagggtg agcgccatga aaaacggcca gctgttctac      480

aatctgactg tgagcgtggc taagtacccc acctttaaat ccttccagtg cgtgaacaat      540

ctgaccagcg tgtacctgaa cggcgatctg gtgtacacaa gcaatgagac taccgacgtg      600

acttccgccg gagtgtactt taaagctgga gggcctatca catacaaggt gatgagagaa      660

gtgaaagccc tggcttactt cgtgaacggc actgcacagg atgtgattct gtgcgatggc      720

tccccacgcg gactgctggc ctgccagtac aacaccggga atttcagcga tggcttttac      780

cccttcatca actccagcct ggtgaagcag aaatttattg tgtacagaga gaactccgtg      840

aatacaactt tcacactgca caacttcact tttcacaatg aaaccggcgc taaccccaat      900

cctagcggag tgcagaacat ccagacatac cagacacaga ctgcacagag cgggtactac      960

aacttcaatt tttccttcct gtccagcttt gtgtacaagg agagcaactt catgtacggc     1020

agctaccacc catcctgcaa ttttcggctg gaaacaatca acaatggact gtggttcaac     1080

tccctgagcg tgtccattgc atacgggccc ctgcagggcg gatgcaaaca gagcgtgttt     1140

tccggcagag ctacttgctg ctacgcatac agctacggcg gaccttccct gtgcaagggg     1200

gtgtacagcg gcgagctgga tctgaatttc gaatgcggac tgctggtgta cgtgaccaaa     1260

agcggagggt ccaggatcca gaccgccaca gagccacccg tgatcacacg ccacaactac     1320

aacaatatta ctctgaacac ctgcgtggac tacaatatct acgggaggac aggacagggg     1380

ttcattacaa acgtgactga tagcgcagtg tcctacaatt acctggcaga tgctgggctg     1440

gcaatcctgg atactagcgg ctccatcgac atttttgtgg tgcagggaga gtacgggctg     1500

acctactaca aggtgaaccc ctgcgaagat gtgaatcagc agttcgtggt gagcggcgga     1560

aaactggtgg gcatcctgac aagccgcaac gagactggat cccagctgct ggaaaaccag     1620

ttttacatca agattaccaa tggaacaaga aggttcagaa gaagcatcac cgagaacgtg     1680

gctaattgcc cctacgtgtc ctacggaaag ttttgcatta aaccagacgg gagcatcgct     1740

actattgtgc ccaagcagct ggagcagttt gtggcacctc tgctgaacgt gaccgaaaat     1800

gtgctgatcc ctaacagctt caatctgact gtgaccgatg aatacatcca gacacggatg     1860

gacaaagtgc agattaactg cctgcagtac gtgtgcggaa atagcctgga ttgcagagat     1920

ctgttccagc agtacgggcc tgtgtgcgat aacatcctga gcgtggtgaa ttccattggc     1980

cagaaagagg atatggaact gctgaacttt tactccagca ccaaacctgc cggctttaac     2040

acacctttcc tgagcaatgt gtccaccggc gagttcaata tctccctgct gctgaccaca     2100

ccatccagcc ccagaaggcg cagctttatt gaggatctgc tgttcacaag cgtggaatcc     2160

gtggggctgc ccaccgatga cgcatacaag aactgcacag ccggccctct gggattcctg     2220

aaagacctgg cttgcgcacg ggagtacaat ggcctgctgg tgctgcctcc aatcattacc     2280

gccgaaatgc agactctgta cacctccagc ctggtggcaa gcatggcctt tggcggaatc     2340

acagccgctg gggccattcc cttcgctact cagctgcagg ctagaatcaa ccacctgggc     2400

attactcagt ccctgctgct gaagaaccag gagaaaatcg cagccagctt taataaggca     2460

attggacgga tgcaggaagg gttcagaagc acctccctgg ccctgcagca gatccaggat     2520

gtggtgaaca agcagtccgc tattctgaca gagactatgg caagcctgaa caaaaatttt     2580

ggcgctatct ccagcgtgat ccaggaaatt taccagcagc tggatgcaat ccaggccaac     2640

gctcaggtgg accggctgat tacaggaaga ctgtccagcc tgagcgtgct ggcatccgca     2700

aagcaggctg agcacatcag ggtgtcccag cagcgcgagc tggctacaca gaagatcaac     2760

gaatgcgtga aaagccagtc cattcggtac agcttctgcg gcaatggaag acacgtgctg     2820

actatccctc agaacgcacc aaatggcatc gtgtttattc acttcagcta cactccagac     2880

tcctttgtga acgtgaccgc catcgtggga ttctgcgtga agccagctaa tgcatcccag     2940

tacgcaattg tgcccgccaa cggcagaggc atctttattc aagtgaatgg aagctactac     3000

atcactgcta gggatatgta catgcccaga gctatcaccg caggggacat tgtgaccctg     3060

acaagctgcc aggcaaacta cgtgtccgtg aataaaaccg tgattactac cttcgtggat     3120

aacgatgact ttgatttcaa tgacgagctg tccaagtggt ggaacgacac aaaacacgaa     3180

ctgcctgatt ttgacaagtt caattacact gtgccaatcc tggatattga cagcgagatc     3240

gaccgcattc agggagtgat ccaggggctg aacgatagcc tgattgacct ggaaaaactg     3300

tccatcctga agacatacat taaatggcct tggtacgtgt ggctggccat cgcttttgca     3360

accatcattt tcatcctgat tctgggatgg gtgttcttta tgacagggtg ctgcggctgc     3420

tgctgcggat gcttcgggat tatgccactg atgagcaagt gcgggaagaa atccagctac     3480

tatacaacct ttgacaatga tgtggtgaca gagcagaatc gccctaagaa atccgtgtga     3540

gtttaaac                                                              3548


<210>  15
<211>  1658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  15
gtttaaactt aagaaaaaat acgggtagaa gccaccatgc tggtgactcc actgctgctg       60

gtgactctgc tgtgcgtgct gtgttccgcc gccctgtacg attcatcatc atacgtgtac      120

tattaccagt ccgcttttag gccccctaat ggatggcacc tgcacggcgg agcttacgca      180

gtggtgaata tcagctccga gagcaacaat gctggaagct cccctggatg cattgtggga      240

actattcacg gcggcagagt ggtgaacgct agctccattg ccatgaccgc tccaagctcc      300

ggaatggcct ggagctccag ccagttctgc acagctcact gcaattttag cgataccaca      360

gtgttcgtga cccactgcta caagtacgac ggctgcccaa tcacaggaat gctgcagaag      420

aactttctga gggtgagcgc catgaaaaac ggccagctgt tctacaatct gactgtgagc      480

gtggctaagt accccacctt taaatccttc cagtgcgtga acaatctgac cagcgtgtac      540

ctgaacggcg atctggtgta cacaagcaat gagactaccg acgtgacttc cgccggagtg      600

tactttaaag ctggagggcc tatcacatac aaggtgatga gagaagtgaa agccctggct      660

tacttcgtga acggcactgc acaggatgtg attctgtgcg atggctcccc acgcggactg      720

ctggcctgcc agtacaacac cgggaatttc agcgatggct tttacccctt catcaactcc      780

agcctggtga agcagaaatt tattgtgtac agagagaact ccgtgaatac aactttcaca      840

ctgcacaact tcacttttca caatgaaacc ggcgctaacc ccaatcctag cggagtgcag      900

aacatccaga cataccagac acagactgca cagagcgggt actacaactt caatttttcc      960

ttcctgtcca gctttgtgta caaggagagc aacttcatgt acggcagcta ccacccatcc     1020

tgcaattttc ggctggaaac aatcaacaat ggactgtggt tcaactccct gagcgtgtcc     1080

attgcatacg ggcccctgca gggcggatgc aaacagagcg tgttttccgg cagagctact     1140

tgctgctacg catacagcta cggcggacct tccctgtgca agggggtgta cagcggcgag     1200

ctggatctga atttcgaatg cggactgctg gtgtacgtga ccaaaagcgg agggtccagg     1260

atccagaccg ccacagagcc acccgtgatc acacgccaca actacaacaa tattactctg     1320

aacacctgcg tggactacaa tatctacggg aggacaggac aggggttcat tacaaacgtg     1380

actgatagcg cagtgtccta caattacctg gcagatgctg ggctggcaat cctggatact     1440

agcggctcca tcgacatttt tgtggtgcag ggagagtacg ggctgaccta ctacaaggtg     1500

aacccctgcg aagatgtgaa tcagcagttc gtggtgagcg gcggaaaact ggtgggcatc     1560

ctgacaagcc gcaacgagac tggatcccag ctgctggaaa accagtttta catcaagatt     1620

accaatggaa caagaaggtt cagaagatga gtttaaac                             1658


<210>  16
<211>  1928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  16
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catgctggtg       60

actccactgc tgctggtgac tctgctgtgc gtgctgtgtt ccgccgccct gtacgattca      120

tcatcatacg tgtactatta ccagtccgct tttaggcccc ctaatggatg gcacctgcac      180

ggcggagctt acgcagtggt gaatatcagc tccgagagca acaatgctgg aagctcccct      240

ggatgcattg tgggaactat tcacggcggc agagtggtga acgctagctc cattgccatg      300

accgctccaa gctccggaat ggcctggagc tccagccagt tctgcacagc tcactgcaat      360

tttagcgata ccacagtgtt cgtgacccac tgctacaagt acgacggctg cccaatcaca      420

ggaatgctgc agaagaactt tctgagggtg agcgccatga aaaacggcca gctgttctac      480

aatctgactg tgagcgtggc taagtacccc acctttaaat ccttccagtg cgtgaacaat      540

ctgaccagcg tgtacctgaa cggcgatctg gtgtacacaa gcaatgagac taccgacgtg      600

acttccgccg gagtgtactt taaagctgga gggcctatca catacaaggt gatgagagaa      660

gtgaaagccc tggcttactt cgtgaacggc actgcacagg atgtgattct gtgcgatggc      720

tccccacgcg gactgctggc ctgccagtac aacaccggga atttcagcga tggcttttac      780

cccttcatca actccagcct ggtgaagcag aaatttattg tgtacagaga gaactccgtg      840

aatacaactt tcacactgca caacttcact tttcacaatg aaaccggcgc taaccccaat      900

cctagcggag tgcagaacat ccagacatac cagacacaga ctgcacagag cgggtactac      960

aacttcaatt tttccttcct gtccagcttt gtgtacaagg agagcaactt catgtacggc     1020

agctaccacc catcctgcaa ttttcggctg gaaacaatca acaatggact gtggttcaac     1080

tccctgagcg tgtccattgc atacgggccc ctgcagggcg gatgcaaaca gagcgtgttt     1140

tccggcagag ctacttgctg ctacgcatac agctacggcg gaccttccct gtgcaagggg     1200

gtgtacagcg gcgagctgga tctgaatttc gaatgcggac tgctggtgta cgtgaccaaa     1260

agcggagggt ccaggatcca gaccgccaca gagccacccg tgatcacacg ccacaactac     1320

aacaatatta ctctgaacac ctgcgtggac tacaatatct acgggaggac aggacagggg     1380

ttcattacaa acgtgactga tagcgcagtg tcctacaatt acctggcaga tgctgggctg     1440

gcaatcctgg atactagcgg ctccatcgac atttttgtgg tgcagggaga gtacgggctg     1500

acctactaca aggtgaaccc ctgcgaagat gtgaatcagc agttcgtggt gagcggcgga     1560

aaactggtgg gcatcctgac aagccgcaac gagactggat cccagctgct ggaaaaccag     1620

ttttacatca agattaccaa tggaacaaga aggttcagaa gaattgacct ggaaaaactg     1680

tccatcctga agacatacat taaatggcct tggtacgtgt ggctggccat cgcttttgca     1740

accatcattt tcatcctgat tctgggatgg gtgttcttta tgacagggtg ctgcggctgc     1800

tgctgcggat gcttcgggat tatgccactg atgagcaagt gcgggaagaa atccagctac     1860

tatacaacct ttgacaatga tgtggtgaca gagcagaatc gccctaagaa atccgtgtga     1920

gtttaaac                                                              1928


<210>  17
<211>  1844
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  17
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catgctggtg       60

actccactgc tgctggtgac tctgctgtgc gtgctgtgtt ccgccgccct gtacgattca      120

tcatcatacg tgtactatta ccagtccgct tttaggcccc ctaatggatg gcacctgcac      180

ggcggagctt acgcagtggt gaatatcagc tccgagagca acaatgctgg aagctcccct      240

ggatgcattg tgggaactat tcacggcggc agagtggtga acgctagctc cattgccatg      300

accgctccaa gctccggaat ggcctggagc tccagccagt tctgcacagc tcactgcaat      360

tttagcgata ccacagtgtt cgtgacccac tgctacaagt acgacggctg cccaatcaca      420

ggaatgctgc agaagaactt tctgagggtg agcgccatga aaaacggcca gctgttctac      480

aatctgactg tgagcgtggc taagtacccc acctttaaat ccttccagtg cgtgaacaat      540

ctgaccagcg tgtacctgaa cggcgatctg gtgtacacaa gcaatgagac taccgacgtg      600

acttccgccg gagtgtactt taaagctgga gggcctatca catacaaggt gatgagagaa      660

gtgaaagccc tggcttactt cgtgaacggc actgcacagg atgtgattct gtgcgatggc      720

tccccacgcg gactgctggc ctgccagtac aacaccggga atttcagcga tggcttttac      780

cccttcatca actccagcct ggtgaagcag aaatttattg tgtacagaga gaactccgtg      840

aatacaactt tcacactgca caacttcact tttcacaatg aaaccggcgc taaccccaat      900

cctagcggag tgcagaacat ccagacatac cagacacaga ctgcacagag cgggtactac      960

aacttcaatt tttccttcct gtccagcttt gtgtacaagg agagcaactt catgtacggc     1020

agctaccacc catcctgcaa ttttcggctg gaaacaatca acaatggact gtggttcaac     1080

tccctgagcg tgtccattgc atacgggccc ctgcagggcg gatgcaaaca gagcgtgttt     1140

tccggcagag ctacttgctg ctacgcatac agctacggcg gaccttccct gtgcaagggg     1200

gtgtacagcg gcgagctgga tctgaatttc gaatgcggac tgctggtgta cgtgaccaaa     1260

agcggagggt ccaggatcca gaccgccaca gagccacccg tgatcacacg ccacaactac     1320

aacaatatta ctctgaacac ctgcgtggac tacaatatct acgggaggac aggacagggg     1380

ttcattacaa acgtgactga tagcgcagtg tcctacaatt acctggcaga tgctgggctg     1440

gcaatcctgg atactagcgg ctccatcgac atttttgtgg tgcagggaga gtacgggctg     1500

acctactaca aggtgaaccc ctgcgaagat gtgaatcagc agttcgtggt gagcggcgga     1560

aaactggtgg gcatcctgac aagccgcaac gagactggat cccagctgct ggaaaaccag     1620

ttttacatca agattaccaa tggaacaaga aggttcagaa gaagcacatc tgctctcatt     1680

acctatatcg ttttgactat catatctctt gtttttggta tacttagcct gattctagca     1740

tgctacctaa tgtacaagca aaaggcgcaa caaaagacct tattatggct tgggaataat     1800

actctagatc agatgagagc cactacaaaa atgtgagttt aaac                      1844


<210>  18
<211>  1826
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  18
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catgctggtg       60

actccactgc tgctggtgac tctgctgtgc gtgctgtgtt ccgccgccct gtacgattca      120

tcatcatacg tgtactatta ccagtccgct tttaggcccc ctaatggatg gcacctgcac      180

ggcggagctt acgcagtggt gaatatcagc tccgagagca acaatgctgg aagctcccct      240

ggatgcattg tgggaactat tcacggcggc agagtggtga acgctagctc cattgccatg      300

accgctccaa gctccggaat ggcctggagc tccagccagt tctgcacagc tcactgcaat      360

tttagcgata ccacagtgtt cgtgacccac tgctacaagt acgacggctg cccaatcaca      420

ggaatgctgc agaagaactt tctgagggtg agcgccatga aaaacggcca gctgttctac      480

aatctgactg tgagcgtggc taagtacccc acctttaaat ccttccagtg cgtgaacaat      540

ctgaccagcg tgtacctgaa cggcgatctg gtgtacacaa gcaatgagac taccgacgtg      600

acttccgccg gagtgtactt taaagctgga gggcctatca catacaaggt gatgagagaa      660

gtgaaagccc tggcttactt cgtgaacggc actgcacagg atgtgattct gtgcgatggc      720

tccccacgcg gactgctggc ctgccagtac aacaccggga atttcagcga tggcttttac      780

cccttcatca actccagcct ggtgaagcag aaatttattg tgtacagaga gaactccgtg      840

aatacaactt tcacactgca caacttcact tttcacaatg aaaccggcgc taaccccaat      900

cctagcggag tgcagaacat ccagacatac cagacacaga ctgcacagag cgggtactac      960

aacttcaatt tttccttcct gtccagcttt gtgtacaagg agagcaactt catgtacggc     1020

agctaccacc catcctgcaa ttttcggctg gaaacaatca acaatggact gtggttcaac     1080

tccctgagcg tgtccattgc atacgggccc ctgcagggcg gatgcaaaca gagcgtgttt     1140

tccggcagag ctacttgctg ctacgcatac agctacggcg gaccttccct gtgcaagggg     1200

gtgtacagcg gcgagctgga tctgaatttc gaatgcggac tgctggtgta cgtgaccaaa     1260

agcggagggt ccaggatcca gaccgccaca gagccacccg tgatcacacg ccacaactac     1320

aacaatatta ctctgaacac ctgcgtggac tacaatatct acgggaggac aggacagggg     1380

ttcattacaa acgtgactga tagcgcagtg tcctacaatt acctggcaga tgctgggctg     1440

gcaatcctgg atactagcgg ctccatcgac atttttgtgg tgcagggaga gtacgggctg     1500

acctactaca aggtgaaccc ctgcgaagat gtgaatcagc agttcgtggt gagcggcgga     1560

aaactggtgg gcatcctgac aagccgcaac gagactggat cccagctgct ggaaaaccag     1620

ttttacatca agattaccaa tggaagcaca tctgctctca ttacctatat cgttttgact     1680

atcatatctc ttgtttttgg tatacttagc ctgattctag catgctacct aatgtacaag     1740

caaaaggcgc aacaaaagac cttattatgg cttgggaata atactctaga tcagatgaga     1800

gccactacaa aaatgtgagt ttaaac                                          1826


<210>  19
<211>  2006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized viral protein coding sequence

<400>  19
gtttaaacta gctacattta agattaagaa aaaatacggg tagaagccac catgctggtg       60

actccactgc tgctggtgac tctgctgtgc gtgctgtgtt ccgccgccct gtacgattca      120

agcatcaccg agaacgtggc taattgcccc tacgtgtcct acggaaagtt ttgcattaaa      180

ccagacggga gcatcgctac tattgtgccc aagcagctgg agcagtttgt ggcacctctg      240

ctgaacgtga ccgaaaatgt gctgatccct aacagcttca atctgactgt gaccgatgaa      300

tacatccaga cacggatgga caaagtgcag attaactgcc tgcagtacgt gtgcggaaat      360

agcctggatt gcagagatct gttccagcag tacgggcctg tgtgcgataa catcctgagc      420

gtggtgaatt ccattggcca gaaagaggat atggaactgc tgaactttta ctccagcacc      480

aaacctgccg gctttaacac acctttcctg agcaatgtgt ccaccggcga gttcaatatc      540

tccctgctgc tgaccacacc atccagcccc agaaggcgca gctttattga ggatctgctg      600

ttcacaagcg tggaatccgt ggggctgccc accgatgacg catacaagaa ctgcacagcc      660

ggccctctgg gattcctgaa agacctggct tgcgcacggg agtacaatgg cctgctggtg      720

ctgcctccaa tcattaccgc cgaaatgcag actctgtaca cctccagcct ggtggcaagc      780

atggcctttg gcggaatcac agccgctggg gccattccct tcgctactca gctgcaggct      840

agaatcaacc acctgggcat tactcagtcc ctgctgctga agaaccagga gaaaatcgca      900

gccagcttta ataaggcaat tggacggatg caggaagggt tcagaagcac ctccctggcc      960

ctgcagcaga tccaggatgt ggtgaacaag cagtccgcta ttctgacaga gactatggca     1020

agcctgaaca aaaattttgg cgctatctcc agcgtgatcc aggaaattta ccagcagctg     1080

gatgcaatcc aggccaacgc tcaggtggac cggctgatta caggaagact gtccagcctg     1140

agcgtgctgg catccgcaaa gcaggctgag cacatcaggg tgtcccagca gcgcgagctg     1200

gctacacaga agatcaacga atgcgtgaaa agccagtcca ttcggtacag cttctgcggc     1260

aatggaagac acgtgctgac tatccctcag aacgcaccaa atggcatcgt gtttattcac     1320

ttcagctaca ctccagactc ctttgtgaac gtgaccgcca tcgtgggatt ctgcgtgaag     1380

ccagctaatg catcccagta cgcaattgtg cccgccaacg gcagaggcat ctttattcaa     1440

gtgaatggaa gctactacat cactgctagg gatatgtaca tgcccagagc tatcaccgca     1500

ggggacattg tgaccctgac aagctgccag gcaaactacg tgtccgtgaa taaaaccgtg     1560

attactacct tcgtggataa cgatgacttt gatttcaatg acgagctgtc caagtggtgg     1620

aacgacacaa aacacgaact gcctgatttt gacaagttca attacactgt gccaatcctg     1680

gatattgaca gcgagatcga ccgcattcag ggagtgatcc aggggctgaa cgatagcctg     1740

attgacctgg aaaaactgtc catcctgaag acatacatta aatggccttg gtacgtgtgg     1800

ctggccatcg cttttgcaac catcattttc atcctgattc tgggatgggt gttctttatg     1860

acagggtgct gcggctgctg ctgcggatgc ttcgggatta tgccactgat gagcaagtgc     1920

gggaagaaat ccagctacta tacaaccttt gacaatgatg tggtgacaga gcagaatcgc     1980

cctaagaaat ccgtgtgagt ttaaac                                          2006


<210>  20
<211>  553
<212>  PRT
<213>  Newcastle Disease Virus

<400>  20

Met Gly Ser Arg Pro Ser Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      


Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          


Asp Gly Arg Pro Leu Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              


Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  


Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  


Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      


Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         


Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 


Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 


Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     


Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         


Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             


Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 


Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 


Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Val Gly 
                245                 250                 255     


Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         


Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             


Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 


Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 


Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     


Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         


Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             


Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 


Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 


Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     


Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         


Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             


Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 


Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 


Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     


Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         


Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             


Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 


Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             


