                         SEQUENCE LISTING

<110>  MSM Protein Technologies Inc.
 
<120>  ANTI-CXCR4 ANTIBODIES

<130>  MSM-001WO01

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1L

<400>  1

Ser Ser Tyr Leu Ala Trp Tyr 
1               5           


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2L

<400>  2

Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3L, variant 1

<400>  3

Gln Gln Ser Asp Tyr Ser Tyr Pro Phe 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3L, variant 2

<400>  4

Gln Gln Trp Ser Ser Asp Ser Val 
1               5               


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1H, variant 1

<400>  5

Ser Ser Tyr Ala Met Ser 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1H, variant 2

<400>  6

Ser Pro Tyr Ser Ile Thr 
1               5       


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2H, variant 1

<400>  7

Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10              


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2H, variant 2

<400>  8

Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Gly Ser Thr Arg 
1               5                   10                  


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2H, variant 3

<400>  9

Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Thr Arg 
1               5                   10          


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2H, variant 4

<400>  10

Trp Val Ser Gln Ile Asn Ser Tyr Asn Gly Lys Thr Tyr 
1               5                   10              


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3H, variant 1

<400>  11

Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr Arg Trp His Gly Tyr 
1               5                   10                  15      


Gly Ser Thr His Ala Leu Asp 
            20              


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3H, variant 2

<400>  12

Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr His Trp His Gly Tyr 
1               5                   10                  15      


Gly Ser Thr His Ala Leu Asp 
            20              


<210>  13
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region LCVR, variant 1

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asp Tyr Ser Tyr 
                85                  90                  95      


Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110     


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region LCVR, variant 2

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Ser 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  15
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region HCVR, variant 1

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr Arg Trp His Gly Tyr 
            100                 105                 110         


Gly Ser Thr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  16
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region HCVR, variant 2

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr His Trp His Gly Tyr 
            100                 105                 110         


Gly Ser Thr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  17
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region HCVR, variant 3

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Ser Thr Arg Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr His Trp His Gly 
            100                 105                 110         


Tyr Gly Ser Thr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  18
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region HCVR, variant 4

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr His Trp His Gly Tyr Gly 
            100                 105                 110         


Ser Thr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  19
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region HCVR, variant 5

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Pro Tyr 
            20                  25                  30          


Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gln Ile Asn Ser Tyr Asn Gly Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Lys Thr Arg Val Tyr Gly Tyr His Trp His Gly Tyr 
            100                 105                 110         


Gly Ser Thr His Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1L

<400>  20
tcctcttacc tggcctggta t                                                 21


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2L

<400>  21
ctgctgatct atggcgcctc ttctagagcc                                        30


<210>  22
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3L, variant 1

<400>  22
cagcagtccg actactccta ccccttc                                           27


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3L, variant 2

<400>  23
cagcagtggt cctccgactc cgtg                                              24


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1H, variant 1

<400>  24
tccagctacg ccatgtcc                                                     18


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1H, variant 2

<400>  25
tccccctact ctatcacc                                                     18


<210>  26
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2H, variant 1

<400>  26
tgggtgtccg ccatctctgg ctctggcggc tctacctac                              39


<210>  27
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD2H, variant 2

<400>  27
tgggtgtccg ccatcagtgg ctctggcgga ggctctacca ga                          42


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2H, variant 3

<400>  28
tgggtgtccg ccatctccgg ctccggcggc accaga                                 36


<210>  29
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2H, variant 4

<400>  29
tgggtgtccc agatcaactc ctacaacggc aagacctac                              39


<210>  30
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3H, variant 1

<400>  30
gctagacagg gcaagacccg ggtgtacggc taccgttggc acggctatgg ctctacccac       60

gccctggat                                                               69


<210>  31
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3H, variant 2

<400>  31
gctagacagg gcaagacccg ggtgtacggc taccactggc acggctatgg ctctacccac       60

gccctggat                                                               69


<210>  32
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCVR, variant 1

<400>  32
gagatcgtgc tgacccagtc tcctggcacc ctgtctctga gccctggcga gagagctacc       60

ctgtcctgca gagcctccca gtccgtgtcc tcctcttacc tggcctggta tcagcagaag      120

cccggccagg ctccccggct gctgatctat ggcgcctctt ctagagccac cggcatcccc      180

gacagattct ccggctctgg ctctggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagtccgact actcctaccc cttcaccttc      300

ggccagggca ccaaggtgga aatcaagcgg acc                                   333


<210>  33
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCVR, variant 2

<400>  33
gagatcgtgc tgacccagtc ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgtcc tcctcctacc tggcctggta tcagcagaag      120

cccggccagg cccctcggct gctgatctac ggcgcctctt ccagagccac cggcatccct      180

gaccggttct ccggctctgg ctccggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagtggtcct ccgactccgt gaccttcggc      300

cagggcacca aggtggaaat caagcggacc                                       330


<210>  34
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR, variant 1

<400>  34
gaagtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctacgcca tgtcctgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtccgcc atctctggct ctggcggctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagacagggc      300

aagacccggg tgtacggcta ccgttggcac ggctatggct ctacccacgc cctggattat      360

tggggccagg gcaccctcgt gaccgtgtcc tct                                   393


<210>  35
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR, variant 2

<400>  35
gaagtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctacgcca tgtcctgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtccgcc atctctggct ctggcggctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagacagggc      300

aagacccggg tgtacggcta ccactggcac ggctatggct ctacccacgc cctggattat      360

tggggccagg gcaccctcgt gaccgtgtcc tct                                   393


<210>  36
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR, variant 3

<400>  36
gaagtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctacgcca tgtcctgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtccgcc atcagtggct ctggcggagg ctctaccaga      180

tacgccgact ctgtgaaggg ccggttcacc atctcccggg acaactccaa gaacaccctg      240

tacctgcaga tgaactccct gcgggccgag gacaccgccg tgtactactg tgctagacag      300

ggcaagaccc gggtgtacgg ctaccactgg cacggctacg gctctaccca cgccctggat      360

tattggggcc agggcaccct cgtgaccgtg tcctct                                396


<210>  37
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR, variant 4

<400>  37
gaggtgcagc tgctggaatc cggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agctacgcca tgtcctgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgtccgcc atctccggct ccggcggcac cagatacgcc      180

gactctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgccag acagggcaag      300

acccgggtgt acggctacca ctggcacggc tacggctcca cccacgccct ggattattgg      360

ggccagggca ccctggtgac agtgtcctcc                                       390


<210>  38
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR, variant 5

<400>  38
gaagtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctacgcca tgtcctgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtccgcc atctctggct ctggcggctc tacctactac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagacagggc      300

aagacccggg tgtacggcta ccactggcac ggctatggct ctacccacgc cctggattat      360

tggggccagg gcaccctcgt gaccgtgtcc tct                                   393


