                         SEQUENCE LISTING

<110>  Younis, Shady
       Kemal, Wael
       Akusjrvi, Gran
       Andersson, Leif
 
<120>  Methods for identifying new therapeutic agents

<130>  ZC3H11A

<150>  SE 1730023-7
<151>  2017-01-31

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  5155
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (998)..(3430)

<400>  1
ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca agcaagaaga       60

aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcggtaaa gtttctgttc      120

tctgggtccc ggtactttgg agcttgtctc aaactccaca tacagaaagc caccgacctt      180

attccggtat cctacaccca ttccccactc tcattacact cccacccctg gccctcagcg      240

tcggagtcaa gagcaacagg gacacttccg ttctccttgt aggactggtg aaaccgtaat      300

gaagaacacc cctaaactcc cataatcggt gcggattcct atggggaagg cctatattgt      360

tgacatcttc caggccttgg ttctggacct tgagaaagag gctgtggaac tagagatagc      420

gatgcttttt aggatttggg gatattccct gcccaaaaaa ttcctggaaa attgactagt      480

attaagtcta tggaagatgg agtttttttt catgatcctt taactctcaa gttcatcttt      540

aaatgaactc tttttttttg tttttttttt gttttgtttt gttttgtttt tgaggagata      600

actaacccta gctgtctcca gtctgacaaa ggttatttga atggacttaa tctcccagta      660

gttgggagat gttttaaaaa cacatgctgt gtttgaattg tggctgagag gttttcttgg      720

caatgtgagg aggaaatttt tttctgcctc attattatta attcatggat tgagtgttgg      780

ttcgacctac aggcgtaata gattggaact cagtgaagac acagatgttc ctgttcagag      840

caaccagcta atgattacag tttaaagaca atttctgtga tcaagttgtc atttggaaga      900

ttaaacccat ttcacgagga cttggagcct ggtccttgct ttgaggaagc agtggcttgt      960

ttcaagaagc cacttctgat ctaagaatct acccagc atg cct aat caa gga gaa      1015
                                         Met Pro Asn Gln Gly Glu          
                                         1               5                

gac tgc tat ttt ttt ttc tat tcc aca tgt acc aaa ggt gac agc tgc       1063
Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys Thr Lys Gly Asp Ser Cys           
            10                  15                  20                    

cca ttc cgt cac tgt gaa gct gca ata gga aat gaa act gtt tgc aca       1111
Pro Phe Arg His Cys Glu Ala Ala Ile Gly Asn Glu Thr Val Cys Thr           
        25                  30                  35                        

tta tgg caa gaa ggg cgc tgt ttt cga cag gtg tgc agg ttt cgg cac       1159
Leu Trp Gln Glu Gly Arg Cys Phe Arg Gln Val Cys Arg Phe Arg His           
    40                  45                  50                            

atg gag att gat aaa aaa cgc agt gaa att cct tgt tat tgg gaa aat       1207
Met Glu Ile Asp Lys Lys Arg Ser Glu Ile Pro Cys Tyr Trp Glu Asn           
55                  60                  65                  70            

cag cca aca gga tgt caa aaa tta aac tgc gct ttc cat cac aat aga       1255
Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys Ala Phe His His Asn Arg           
                75                  80                  85                

gga cga tat gtt gat ggc ctt ttc cta cct ccg agc aaa act gtg ttg       1303
Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro Pro Ser Lys Thr Val Leu           
            90                  95                  100                   

ccc act gtg cct gag tca cca gaa gag gaa gtg aag gct agc caa ctt       1351
Pro Thr Val Pro Glu Ser Pro Glu Glu Glu Val Lys Ala Ser Gln Leu           
        105                 110                 115                       

tca gtt cag cag aac aaa ttg tct gtc cag tcc aat cct tcc cct cag       1399
Ser Val Gln Gln Asn Lys Leu Ser Val Gln Ser Asn Pro Ser Pro Gln           
    120                 125                 130                           

ctg cgg agc gtt atg aaa gta gaa agt tcc gaa aat gtt cct agc ccc       1447
Leu Arg Ser Val Met Lys Val Glu Ser Ser Glu Asn Val Pro Ser Pro           
135                 140                 145                 150           

acg cat cca cca gtt gta att aat gct gca gat gat gat gaa gat gat       1495
Thr His Pro Pro Val Val Ile Asn Ala Ala Asp Asp Asp Glu Asp Asp           
                155                 160                 165               

gat gat cag ttt tct gag gaa ggt gat gaa acc aaa aca cct acc ctg       1543
Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu Thr Lys Thr Pro Thr Leu           
            170                 175                 180                   

caa cca act cct gaa gtt cac aat gga tta cga gtg act tct gtc cgg       1591
Gln Pro Thr Pro Glu Val His Asn Gly Leu Arg Val Thr Ser Val Arg           
        185                 190                 195                       

aaa cct gca gtc aat ata aag caa ggt gaa tgt ttg aat ttt gga ata       1639
Lys Pro Ala Val Asn Ile Lys Gln Gly Glu Cys Leu Asn Phe Gly Ile           
    200                 205                 210                           

aaa act ctt gag gaa att aag tca aag aaa atg aag gaa aaa tct aag       1687
Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys Met Lys Glu Lys Ser Lys           
215                 220                 225                 230           

aag caa ggt gag ggt tct tca gga gtt tcc agt ctt tta ctc cac cct       1735
Lys Gln Gly Glu Gly Ser Ser Gly Val Ser Ser Leu Leu Leu His Pro           
                235                 240                 245               

gag ccc gtt cca ggt cct gaa aaa gaa aat gtc agg act gtg gtg agg       1783
Glu Pro Val Pro Gly Pro Glu Lys Glu Asn Val Arg Thr Val Val Arg           
            250                 255                 260                   

aca gta act ctc tcc acc aaa caa gga gaa gaa ccc ttg gtt aga ttg       1831
Thr Val Thr Leu Ser Thr Lys Gln Gly Glu Glu Pro Leu Val Arg Leu           
        265                 270                 275                       

agt ctt act gag aga ctg ggg aaa cga aaa ttt tca gca ggc ggt gac       1879
Ser Leu Thr Glu Arg Leu Gly Lys Arg Lys Phe Ser Ala Gly Gly Asp           
    280                 285                 290                           

agt gat cct cca tta aag cgt agc ctg gca cag agg cta ggg aag aaa       1927
Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala Gln Arg Leu Gly Lys Lys           
295                 300                 305                 310           

gtt gaa gct cca gaa act aac att gac aaa aca cca aag aaa gct caa       1975
Val Glu Ala Pro Glu Thr Asn Ile Asp Lys Thr Pro Lys Lys Ala Gln           
                315                 320                 325               

gtt tcc aag tct ctt aag gag cga tta ggc atg tca gct gat cca gat       2023
Val Ser Lys Ser Leu Lys Glu Arg Leu Gly Met Ser Ala Asp Pro Asp           
            330                 335                 340                   

aat gag gat gca aca gat aaa gtt aat aaa gtt ggt gag atc cat gtg       2071
Asn Glu Asp Ala Thr Asp Lys Val Asn Lys Val Gly Glu Ile His Val           
        345                 350                 355                       

aag aca tta gaa gaa att ctt ctt gaa aga gcc agt cag aaa cgt gga       2119
Lys Thr Leu Glu Glu Ile Leu Leu Glu Arg Ala Ser Gln Lys Arg Gly           
    360                 365                 370                           

gaa ttg caa act aaa ctc aag aca gaa gga cct tca aaa act gat gat       2167
Glu Leu Gln Thr Lys Leu Lys Thr Glu Gly Pro Ser Lys Thr Asp Asp           
375                 380                 385                 390           

tct act tca gga gca aga agc tcc tcc act atc cgt atc aaa acc ttc       2215
Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr Ile Arg Ile Lys Thr Phe           
                395                 400                 405               

tct gag gtc ctg gct gaa aaa aaa cat cgg cag cag gaa gca gag aga       2263
Ser Glu Val Leu Ala Glu Lys Lys His Arg Gln Gln Glu Ala Glu Arg           
            410                 415                 420                   

caa aaa agc aaa aag gat aca act tgc atc aag cta aag att gat agt       2311
Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile Lys Leu Lys Ile Asp Ser           
        425                 430                 435                       

gaa att aaa aaa aca gta gtt ttg cca ccc att gtt gcc agc aga gga       2359
Glu Ile Lys Lys Thr Val Val Leu Pro Pro Ile Val Ala Ser Arg Gly           
    440                 445                 450                           

caa tca gag gag cct gca ggt aaa aca aag tct atg cag gag gtg cac       2407
Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys Ser Met Gln Glu Val His           
455                 460                 465                 470           

atc aag acg ctg gaa gaa att aaa ctg gag aag gca ctg agg gtg cag       2455
Ile Lys Thr Leu Glu Glu Ile Lys Leu Glu Lys Ala Leu Arg Val Gln           
                475                 480                 485               

cag agc tct gag agc agc acc agc tcc ccg tct caa cac gag gcc act       2503
Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro Ser Gln His Glu Ala Thr           
            490                 495                 500                   

cca ggg gca agg cgg ctg ctg cga atc acc aaa aga aca ggg atg aaa       2551
Pro Gly Ala Arg Arg Leu Leu Arg Ile Thr Lys Arg Thr Gly Met Lys           
        505                 510                 515                       

gaa gag aag aac ctt cag gaa gga aat gaa gtt gat tct cag agc agt       2599
Glu Glu Lys Asn Leu Gln Glu Gly Asn Glu Val Asp Ser Gln Ser Ser           
    520                 525                 530                           

att aga aca gaa gct aaa gag gct tca ggt gag acc aca gga gtt gac       2647
Ile Arg Thr Glu Ala Lys Glu Ala Ser Gly Glu Thr Thr Gly Val Asp           
535                 540                 545                 550           

atc act aaa att caa gtc aag aga tgt gag acc atg aga gag aag cac       2695
Ile Thr Lys Ile Gln Val Lys Arg Cys Glu Thr Met Arg Glu Lys His           
                555                 560                 565               

atg cag aaa cag cag gag agg gaa aaa tca gtc ttg aca cct ctt cgg       2743
Met Gln Lys Gln Gln Glu Arg Glu Lys Ser Val Leu Thr Pro Leu Arg           
            570                 575                 580                   

gga gat gta gcc tct tgc aat acc caa gtg gca gag aaa cca gtg ctc       2791
Gly Asp Val Ala Ser Cys Asn Thr Gln Val Ala Glu Lys Pro Val Leu           
        585                 590                 595                       

act gct gtg cca gga atc aca cgg cac ctg acc aag cgg ctt ccc aca       2839
Thr Ala Val Pro Gly Ile Thr Arg His Leu Thr Lys Arg Leu Pro Thr           
    600                 605                 610                           

aag tca tcc cag aag gtg gag gta gaa acc tca ggg att gga gac tca       2887
Lys Ser Ser Gln Lys Val Glu Val Glu Thr Ser Gly Ile Gly Asp Ser           
615                 620                 625                 630           

tta ttg aat gtg aaa tgt gca gca cag acc ttg gaa aaa agg ggt aaa       2935
Leu Leu Asn Val Lys Cys Ala Ala Gln Thr Leu Glu Lys Arg Gly Lys           
                635                 640                 645               

gct aaa ccc aaa gtg aac gtg aag cca tct gtg gtt aaa gtt gtg tca       2983
Ala Lys Pro Lys Val Asn Val Lys Pro Ser Val Val Lys Val Val Ser           
            650                 655                 660                   

tcc ccc aaa ttg gcc cca aaa cgt aag gca gtg gag atg cac gct gct       3031
Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala Val Glu Met His Ala Ala           
        665                 670                 675                       

gtc att gcc gct gtg aag cca ctc agc tcc agc agt gtc cta cag gaa       3079
Val Ile Ala Ala Val Lys Pro Leu Ser Ser Ser Ser Val Leu Gln Glu           
    680                 685                 690                           

ccc cca gcc aaa aag gca gct gtg gct gtt gtc ccg ctt gtc tct gag       3127
Pro Pro Ala Lys Lys Ala Ala Val Ala Val Val Pro Leu Val Ser Glu           
695                 700                 705                 710           

gac aaa tca gtc act gtg cct gaa gca gaa aat cct aga gac agt ctt       3175
Asp Lys Ser Val Thr Val Pro Glu Ala Glu Asn Pro Arg Asp Ser Leu           
                715                 720                 725               

gtg ctg cct cca acc cag tcc tct tca gat tcc tca ccc ccg gag gtg       3223
Val Leu Pro Pro Thr Gln Ser Ser Ser Asp Ser Ser Pro Pro Glu Val           
            730                 735                 740                   

tct ggc cct tcc tca tcc caa atg agc atg aaa act cgc cga ctc agc       3271
Ser Gly Pro Ser Ser Ser Gln Met Ser Met Lys Thr Arg Arg Leu Ser           
        745                 750                 755                       

tct gcc tca aca gga aag ccc cca ctc tct gtg gag gat gat ttt gag       3319
Ser Ala Ser Thr Gly Lys Pro Pro Leu Ser Val Glu Asp Asp Phe Glu           
    760                 765                 770                           

aaa cta ata tgg gag att tca gga ggc aaa ttg gaa gct gag att gac       3367
Lys Leu Ile Trp Glu Ile Ser Gly Gly Lys Leu Glu Ala Glu Ile Asp           
775                 780                 785                 790           

ctg gat cct ggg aaa gat gaa gat gac ctt ctg ctt gag cta tca gaa       3415
Leu Asp Pro Gly Lys Asp Glu Asp Asp Leu Leu Leu Glu Leu Ser Glu           
                795                 800                 805               

atg att gat agc tga aggtggtagt gaggacactt taaaaaaaaa atcgccaaaa       3470
Met Ile Asp Ser                                                           
            810                                                           

aactggactt agtttcatct attgtaacat ttacctgaga tgatcatttc tttagtctag     3530

aatttgcccc aaatcagaag tatacctctg aattatctgt atgtgtcctg gattccttgg     3590

ggtcagattt ttaaagttac tttataacca ttttgtccat ttgatgccat tgtttatcat     3650

cttttgagaa aaaagttctg tcataccctt ctctccacaa aaaagagact gagagggaga     3710

tcaagtgaaa gggtgcaagc gaacttagtg actccttgag gtgtttgtca gttttggctt     3770

ttttcttctt tgttgtattc tttatgtatt gtcttgatgt acttaatatt acctgagttt     3830

gaaatggatg aagacagctg ctaccattaa ggaccaaatt ttatgctacc actaaacaaa     3890

aatacccact cagtctgtgt taaattgtat gtctttttaa aggtatttaa agattcaact     3950

aagctttaaa gagggctgag cagctcagga agcctgtaat gtgggcataa ctctttggac     4010

ctgatcttga tgcttctgct gctctgttag cctctgaaga gcaatatcta atttattatt     4070

actgtaattt tttaaaaggc tttaaagtgc ctcaggggtc ccctgaaact aattttctat     4130

ttctgggatt ccctggattc attatatgag atggtgacat gattagagga attctttttt     4190

agtatgaaaa ttgtcctttt tcttcttcag tacttgcctc cttgctggca ttgaattaac     4250

acagggacaa aatttggtta attttttatt tctaactctc ccaacaaacc cctgttgccc     4310

agtatttgtt tggtggcctt taaccacctg agggaaaaaa tgagcttatt caagctgcca     4370

atatttatct atgggctgta gcagtacact gaattgtact gtgccaggga tattgagatg     4430

ctctgggggt gtattgtata cctgccagtt ttcttcattt ctgaattgag ttttcttttc     4490

ttgatgttgg tttccttcat atcacctcaa ggtttagatt tgtgaaggaa taagcatgat     4550

ggaaataata gtcttgaaag gagatatgtt gtatataatc aggaggaaga ggaaggaagg     4610

acttacccat tttgatattt tgctgtaggt ggccagtttt gtttctcata gggaaatctg     4670

acccacctgt catgttggct cctaaggaac tgctgttgta agcggctcat caagagttga     4730

acttcacgta gccttgttgg gaatatggaa aaggaagaaa gccacaggac tgcccattca     4790

gtcttgggaa gattgggatg attctgcaca agcaaaaatg actgaagttt atgtatagac     4850

acacctctac caatccatct tcagctgact gaatgttgta tgatagccct tctccaaagc     4910

agaggtagaa tgttcaggtt tcaccatgga ttttctactt atttcgtttt tggaatcagc     4970

ttacagattc caggtccctt ttgtatatat tctttattct tttgcttttt taaaaaataa     5030

ttttgtttca tatttaaagc acttgtatta gtcaatgttt cgtgttccgc attatttgaa     5090

ccatttgccc ttacagaaag agaaatactt gtttgtgttt taaataaaac tgatgtagga     5150

aagtc                                                                 5155


<210>  2
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Ile Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Gln 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Thr Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Thr His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu Asn Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Lys Lys Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Ser Leu Thr Glu Arg Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Ala Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Ile Asp Lys 
305                 310                 315                 320 


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Met Ser Ala Asp Pro Asp Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350         


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Ile Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys Arg Gly Glu Leu Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Lys Lys His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Ile Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Ile Val Ala Ser Arg Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Ile Lys Thr Leu Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495     


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Arg Leu Leu Arg Ile Thr 
            500                 505                 510         


Lys Arg Thr Gly Met Lys Glu Glu Lys Asn Leu Gln Glu Gly Asn Glu 
        515                 520                 525             


Val Asp Ser Gln Ser Ser Ile Arg Thr Glu Ala Lys Glu Ala Ser Gly 
    530                 535                 540                 


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560 


Thr Met Arg Glu Lys His Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575     


Val Leu Thr Pro Leu Arg Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590         


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Arg His Leu 
        595                 600                 605             


Thr Lys Arg Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620                 


Ser Gly Ile Gly Asp Ser Leu Leu Asn Val Lys Cys Ala Ala Gln Thr 
625                 630                 635                 640 


Leu Glu Lys Arg Gly Lys Ala Lys Pro Lys Val Asn Val Lys Pro Ser 
                645                 650                 655     


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670         


Val Glu Met His Ala Ala Val Ile Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685             


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Ala Val 
    690                 695                 700                 


Val Pro Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Ala Glu 
705                 710                 715                 720 


Asn Pro Arg Asp Ser Leu Val Leu Pro Pro Thr Gln Ser Ser Ser Asp 
                725                 730                 735     


Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser Met 
            740                 745                 750         


Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu Ser 
        755                 760                 765             


Val Glu Asp Asp Phe Glu Lys Leu Ile Trp Glu Ile Ser Gly Gly Lys 
    770                 775                 780                 


Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp Leu 
785                 790                 795                 800 


Leu Leu Glu Leu Ser Glu Met Ile Asp Ser 
                805                 810 


<210>  3
<211>  455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  3
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccgg tcactgtgaa gctgcaatgt tttagagcta gaaatagcaa      360

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt      420

tctagaccca gctttcttgt acaaagttgg catta                                 455


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
tctttcatgt tgacccccag ta                                                22


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
ctgacgcttt tctcacagag gtt                                               23


<210>  6
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
aaggaaggac ttacccattt tgatatt                                           27


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
tgggtcagat ttccctatga gaa                                               23


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
gcaaagacct gacgccaac                                                    19


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
acatctgctg gaaggtggac                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
actctcttcc gcatcgctgt c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
aagaccgcga agagtttgtc c                                                 21


<210>  12
<211>  816
<212>  PRT
<213>  Sus scrofa

<400>  12

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Gln 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Tyr Trp Glu Asn Gln Pro Met Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80  


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Thr Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110         


Val Lys Ala Ser Gln Leu Thr Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Thr His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175     


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190         


Arg Val Ala Ser Ala Arg Lys Pro Gly Val Asn Leu Lys Gln Gly Glu 
        195                 200                 205             


Cys Leu Asn Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220                 


Met Lys Glu Lys Ser Lys Lys Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240 


Ser Leu Leu Leu Gln Pro Gln Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Asn Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Leu Val Arg Leu Ser Leu Thr Glu Arg Leu Gly Lys Arg Lys 
        275                 280                 285             


Phe Ser Val Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Ile Asn Thr Asp Lys 
305                 310                 315                 320 


Thr Pro Lys Lys Val Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335     


Val Ser Ala Gly Pro Asp Ser Glu Gly Ala Thr Glu Arg Val Thr Lys 
            340                 345                 350         


Val Gly Glu Ile Arg Val Lys Thr Leu Glu Glu Ile Leu Leu Glu Arg 
        355                 360                 365             


Ala Ser Gln Lys Arg Gly Glu Leu Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380                 


Pro Ser Lys Val Asp Asp Ser Thr Ser Gly Thr Arg Thr Ser Ser Thr 
385                 390                 395                 400 


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Lys Lys His Arg 
                405                 410                 415     


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Val Thr Cys Ile 
            420                 425                 430         


Lys Leu Lys Thr Asp Asn Asp Thr Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445             


Val Val Ala Ser Arg Gly Gln Ser Glu Glu Pro Ala Gly Arg Ala Lys 
    450                 455                 460                 


Ser Met Gln Glu Val His Ile Lys Thr Leu Glu Glu Ile Lys Met Glu 
465                 470                 475                 480 


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Gln 
                485                 490                 495     


Pro Gln Pro Glu Ala Thr Pro Gly Ala Arg Arg Phe Leu Arg Ile Thr 
            500                 505                 510         


Lys Lys Thr Gly Ile Gln Glu Glu Lys Lys Leu Gln Glu Glu Asn Glu 
        515                 520                 525             


Val Ala Ser Gln Ser Gly Val Thr Arg Thr Glu Ala Lys Glu Ala Ser 
    530                 535                 540                 


Asp Glu Thr Thr Gly Val Gly Ile Thr Lys Ile Gln Val Lys Arg Cys 
545                 550                 555                 560 


Glu Thr Gly Arg Glu Lys His Val Gln Lys Leu Pro Asp Arg Ser Thr 
                565                 570                 575     


Leu Gln Lys Glu Lys Ser Val Leu Thr Pro Leu Arg Gly Asp Leu Asp 
            580                 585                 590         


Ser Gly Asn Thr Gln Leu Ala Glu Lys Pro Val Leu Ala Thr Val Pro 
        595                 600                 605             


Gly Thr Thr Arg His Leu Thr Lys Arg Leu Pro Thr Lys Ser Ser Gln 
    610                 615                 620                 


Lys Ala Glu Val Glu Thr Ser Gly Ile Gly Asp Ser Met Leu Asn Val 
625                 630                 635                 640 


Lys Cys Ala Ala Gln Ala Leu Asp Lys Arg Gly Lys Ala Lys Pro Lys 
                645                 650                 655     


Val Asn Val Lys Pro Ser Val Val Lys Val Val Ser Ser Pro Lys Leu 
            660                 665                 670         


Ala Pro Lys Arg Lys Ala Ala Glu Val His Pro Ala Val Ile Ala Ala 
        675                 680                 685             


Val Lys Pro Leu Ser Ser Ser Thr Val Leu Gln Glu Ser Pro Ala Lys 
    690                 695                 700                 


Lys Ala Ala Val Ala Val Val Pro Leu Leu Ser Glu Asp Lys Ser Val 
705                 710                 715                 720 


Pro Val Pro Glu Thr Glu Lys Pro Arg Asp Ser Phe Val Leu Pro Pro 
                725                 730                 735     


Thr His Ser Ser Ser Asp Leu Ser Pro Pro Glu Ala Ser Gly Pro Ser 
            740                 745                 750         


Ser Ser Gln Met Thr Thr Lys Thr Arg Arg Leu Ser Ser Thr Ser Thr 
        755                 760                 765             


Gly Lys Pro Pro Leu Ser Met Glu Asp Asp Phe Glu Lys Leu Ile Trp 
    770                 775                 780                 


Glu Ile Ser Gly Gly Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly 
785                 790                 795                 800 


Lys Asp Glu Asp Asp Leu Leu Leu Glu Leu Ser Glu Met Ile Asp Ser 
                805                 810                 815     


<210>  13
<211>  723
<212>  PRT
<213>  Gallus gallus

<400>  13

Met Ser Lys Gln Gly Asp Asp Cys Tyr Phe Tyr Phe Tyr Ser Thr Cys 
1               5                   10                  15      


Asn Lys Gly Asp Asn Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30          


Asn Glu Thr Ile Cys Thr Leu Trp Lys Glu Gly Arg Cys Phe Arg Asn 
        35                  40                  45              


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60                  


Pro Cys Phe Trp Glu Asn Gln Pro Gly Gly Cys Gln Lys Ser Asn Cys 
65                  70                  75                  80  


Ala Phe His His Thr Lys Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95      


Pro Ser Lys Thr Thr Leu Pro Ser Pro Pro Glu Ser Ala Asp Asp Asp 
            100                 105                 110         


Leu Lys Ala Ala Gln Ile Thr Leu Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125             


Ser Asn Pro Ser Pro Gln Leu Arg Gly Val Met Lys Val Glu Asn Ser 
    130                 135                 140                 


Glu Asn Val Pro Ser Pro Thr His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Asp Asp Asp Gln Leu Ser Glu Glu Gly Glu Glu 
                165                 170                 175     


Thr Lys Thr Pro Val Gln Gln Pro Ala Glu Glu Asn His Asn Gly Leu 
            180                 185                 190         


Arg Ile Ile Ser Thr Arg Lys Ser Asn Ala Asp Thr Lys Gln Asp Asp 
        195                 200                 205             


Ser Leu Asn Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Leu Lys Lys 
    210                 215                 220                 


Gln Lys Glu Lys Thr Lys Lys Gln Ser Glu Gly Pro Ser Gly Val Pro 
225                 230                 235                 240 


Ala His Pro Leu Gln Ser Arg Thr Val Pro Val Pro Glu Lys Glu Asn 
                245                 250                 255     


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Ala Lys Gln Gly Glu 
            260                 265                 270         


Glu Pro Val Ile Arg Leu Asn Ile Ala Glu Lys Pro Gly Lys Arg Lys 
        275                 280                 285             


Gly Ser Val Ala Asp Val Ser Gly Leu Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300                 


Glu Arg Leu Gly Arg Lys Ile Glu Val Asp Lys Ala Pro Arg Arg Glu 
305                 310                 315                 320 


Lys Gly Ala Lys Pro Ala Gly Glu Ile His Val Lys Thr Leu Glu Glu 
                325                 330                 335     


Ile Arg Leu Glu Arg Ala Asn Gln Arg Gly Glu Thr Leu Thr Ala Pro 
            340                 345                 350         


Gln Ala Glu Val Cys Cys Lys Val Glu Asp Pro Ser Ser Gly Val Arg 
        355                 360                 365             


Pro Pro Pro Ala Val Arg Ile Lys Thr Phe Ser Glu Ala Leu Ala Glu 
    370                 375                 380                 


Arg Lys Gln Arg Arg Leu Glu Glu Glu Lys Gln Lys Leu Glu Glu Phe 
385                 390                 395                 400 


Leu Thr Glu Lys Arg Ala Glu Gly Glu Arg Lys Lys Gln Arg Ile Leu 
                405                 410                 415     


Pro Pro Ser Val Pro Gly Lys Val Lys Leu Glu Glu Pro Thr Arg Lys 
            420                 425                 430         


Ile Lys Pro Leu Glu Glu Val His Ile Lys Thr Leu Glu Glu Ile Lys 
        435                 440                 445             


Gln Glu Lys Ala Leu Arg Met Gln Gln Ser Gly Glu Asn Val Pro Ala 
    450                 455                 460                 


Pro Ala Ala Gln Pro Gly Pro Ala Pro Ala Gly Arg Lys Leu Leu Arg 
465                 470                 475                 480 


Ile Thr Lys Leu Ala Ala Pro Gly Lys Glu Glu Lys Lys Thr Val Glu 
                485                 490                 495     


Leu Ser Arg Ala Ser Pro Lys Ala Val Ser Ala Pro Ala Glu Pro Ser 
            500                 505                 510         


Asn Gln Ser Ala Pro Asn Ser Lys Ala Gln Val Lys Ser Leu Glu Gly 
        515                 520                 525             


Thr Val Lys Glu Lys Leu Gln Leu Arg Gln Pro Glu Lys Leu Lys Lys 
    530                 535                 540                 


Glu Val Ala Ala Val Pro Ser Ala Thr Glu Glu Thr Val Lys Ala Lys 
545                 550                 555                 560 


Cys Lys Val Cys Val Lys Pro Ser Asp Ser Lys Ala Ser Thr Pro Thr 
                565                 570                 575     


Lys Arg Ala Leu Lys Arg Lys Ala Ala Glu Ile Ser Pro Ser Ala Val 
            580                 585                 590         


Ala Ala Val Lys Pro Leu Ser Ser Thr Glu Thr Glu Glu Pro Pro Ala 
        595                 600                 605             


Lys Lys Ala Ala Leu Thr Ala Ala Pro Ala Leu Pro Glu Asp Ser Leu 
    610                 615                 620                 


Leu Thr Lys Pro Gly Val Glu Lys Pro Pro Ser Ser Leu Glu Leu Gln 
625                 630                 635                 640 


Leu Gly Ser Gln Ala Asp Ser Val Glu Gln Ser Gly Asp Ser Ser Ser 
                645                 650                 655     


Ala Ser Ala Ser Ser Gln Ser Val Ala Lys Ala Gln Gln Leu Ser Ser 
            660                 665                 670         


Thr Gly Ala Gly Lys Ala Pro Leu Ser Val Glu Asp Asp Phe Glu Lys 
        675                 680                 685             


Leu Ile Trp Glu Ile Ser Gly Gly Lys Leu Glu Ala Glu Ile Asp Leu 
    690                 695                 700                 


Asp Pro Gly Lys Asp Glu Asp Asp Leu Leu Leu Glu Leu Ser Glu Met 
705                 710                 715                 720 


Ile Asp Ser 
            


