﻿               SEQUENCE LISTING

<110> ACTICOR BIOTECH
      UNIVERSITÉ PARIS DIDEROT - PARIS 7
      UNIVERSITÉ PARIS XIII
      INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
      (INSERM)
      UNIVERSITÉ PARIS-SUD 11
      Billiald Philippe
      Martine JANDROT-PERRUS
      Gilles AVENARD


<120> INHIBITION OF PLATELET AGGREGATION USING ANTI-HUMAN
      GPVI ANTIBODIES

<130> CV - 739/PCT

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 1
Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 2
Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 3
Gly Thr Val Val Gly Asp Trp Tyr Phe Asp Val 
1               5                   10      

<210> 4
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 4
Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 5
Arg Val Ser Asn Arg Phe Ser 
1               5           

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 6
Leu Gln Leu Thr His Val Pro Trp Thr 
1               5                   

<210> 7
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Heavy chain variable region

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Thr Val Val Gly Asp Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 8
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Light chain variable region

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Thr 
            100                 105                 110         
Arg 
    

<210> 9
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> Light chain variable region

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 10
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> Heavy chain variable region

<400> 10
caggttcagc tggttcagtc aggggctgag gtgaagaagc ctggagcctc agtgaaggtg      60

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt aagacaggct     120

cctggacagg gcctggaatg gatgggaggt atttatccag gaaatggtga tacttcctac     180

aatcagaagt tccagggccg agttactatg actcgggaca cttccacctc tacagtgtac     240

atggagctca gcagcctgag atctgaggac accgcggtct attactgtgc aagaggcacc     300

gtggtcggcg actggtactt cgatgtgtgg ggccaaggca ccctggtcac cgtgagcagt     360


<210> 11
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> Light chain variable region

<400> 11
gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggtga cagagtgacc      60

atcacctgta gaagtagtca gagccttgag aacagcaacg gaaacaccta cctgaattgg     120

taccagcaga agccaggtaa ggctccaaag ctgctgatct acagagtttc caaccgattc     180

tctggtgtgc caagcagatt cagcggtagc ggtagcggta ccgacttcac cttcaccatc     240

agcagcctcc agccagagga catcgccacc tactactgcc tccagctgac tcatgtccca     300

tggaccttcg gtcagggcac caaggtggag atcacccgg                            339


<210> 12
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> Light chain variable region

<400> 12
gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggtga cagagtgacc      60

atcacctgta gtgccagtca gagccttgag aacagcaacg gaaacaccta cctgaattgg     120

taccagcaga agccaggtaa ggctccaaag ctgctgatct acagagtttc caaccgattc     180

tctggtgtgc caagcagatt cagcggtagc ggtagcggta ccgacttcac cctcaccatc     240

agcagcctcc agccagagga cttcgccacc tactactgcc tccagctgac tcatgtccca     300

tggaccttcg gtcagggcac caaggtggag atcaaacgc                            339


<210> 13
<211> 339
<212> PRT
<213> Homo sapiens


<400> 13
Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      
Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          
Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              
Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  
Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  
Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      
Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         
Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             
Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 
Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 
Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     
Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         
Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             
Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Ser Val Ala Glu Phe Ser 
    210                 215                 220                 
Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Lys Val Phe Thr 
225                 230                 235                 240 
Thr Glu Thr Ser Arg Ser Ile Thr Thr Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     
Pro Ala Gly Pro Ala Arg Gln Tyr Tyr Thr Lys Gly Asn Leu Val Arg 
            260                 265                 270         
Ile Cys Leu Gly Ala Val Ile Leu Ile Ile Leu Ala Gly Phe Leu Ala 
        275                 280                 285             
Glu Asp Trp His Ser Arg Arg Lys Arg Leu Arg His Arg Gly Arg Ala 
    290                 295                 300                 
Val Gln Arg Pro Leu Pro Pro Leu Pro Pro Leu Pro Gln Thr Arg Lys 
305                 310                 315                 320 
Ser His Gly Gly Gln Asp Gly Gly Arg Gln Asp Val His Ser Arg Gly 
                325                 330                 335     
Leu Cys Ser 
            

<210> 14
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> Heavy chain constant region

<400> 14
gcctccacca agggtccctc agtcttccca ctggcaccct cctccaagag cacctctggt      60

ggcacagctg ccctgggctg cctggtcaag gactacttcc cagaaccagt gactgtgtca     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ctgctgtctt gcagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agtcgagcct     300

aagtcatgcg acaagactca c                                               321


<210> 15
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> Light chain constant region

<400> 15
actgtggctg caccaagtgt gttcatcttc ccacctagcg atgagcagtt gaaatctgga      60

actgcctctg tcgtgtgcct cctgaacaac ttctacccac gggaggccaa ggtacagtgg     120

aaggtggata acgccctcca atccggtaac tcccaggaga gtgtcacaga gcaagatagc     180

aaggacagca cctacagcct cagcagcacc ctgactctga gcaaagcaga ctacgagaag     240

cacaaggtct acgcctgcga agtcacccat cagggcctga gttcccctgt cacaaagagc     300

ttcaaccggg gagagtgt                                                   318


<210> 16
<211> 66
<212> DNA
<213> Artificial Sequence


<220> 
<223> Signal peptide

<400> 16
atggatatgc gtgtaccagc tcaactactt ggacttctat tgctttggct tcgtggtgct     60

agatgt                                                                66


<210> 17
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> Signal peptide

<400> 17
atggactgga cttggagaat cctattcttg gttgctgcag ctacaggtgc tcattca        57


<210> 18
<211> 762
<212> DNA
<213> Artificial Sequence


<220> 
<223> Heavy chain

<400> 18
gcggccgcca ccatggactg gacttggaga atcctattct tggttgctgc agctacaggt      60

gctcattcac aggttcagct ggttcagtca ggggctgagg tgaagaagcc tggagcctca     120

gtgaaggtgt cctgcaaggc ttctggctac acatttacca gttacaatat gcactgggta     180

agacaggctc ctggacaggg cctggaatgg atgggaggta tttatccagg aaatggtgat     240

acttcctaca atcagaagtt ccagggccga gttactatga ctcgggacac ttccacctct     300

acagtgtaca tggagctcag cagcctgaga tctgaggaca ccgcggtcta ttactgtgca     360

agaggcaccg tggtcggcga ctggtacttc gatgtgtggg gccaaggcac cctggtcacc     420

gtgagcagtg cctccaccaa gggtccctca gtcttcccac tggcaccctc ctccaagagc     480

acctctggtg gcacagctgc cctgggctgc ctggtcaagg actacttccc agaaccagtg     540

actgtgtcat ggaactcagg cgccctgacc agcggcgtgc acaccttccc tgctgtcttg     600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     720

gtcgagccta agtcatgcga caagactcac tgatgaggat cc                        762


<210> 19
<211> 742
<212> DNA
<213> Artificial Sequence


<220> 
<223> Light chain

<400> 19
gacgtcacca tggatatgcg tgtaccagct caactacttg gacttctatt gctttggctt      60

cgtggtgcta gatgtgacat ccagatgacc cagagcccaa gcagcctgag cgccagcgtg     120

ggtgacagag tgaccatcac ctgtagaagt agtcagagcc ttgagaacag caacggaaac     180

acctacctga attggtacca gcagaagcca ggtaaggctc caaagctgct gatctacaga     240

gtttccaacc gattctctgg tgtgccaagc agattcagcg gtagcggtag cggtaccgac     300

ttcaccttca ccatcagcag cctccagcca gaggacatcg ccacctacta ctgcctccag     360

ctgactcatg tcccatggac cttcggtcag ggcaccaagg tggagatcac ccggactgtg     420

gctgcaccaa gtgtgttcat cttcccacct agcgatgagc agttgaaatc tggaactgcc     480

tctgtcgtgt gcctcctgaa caacttctac ccacgggagg ccaaggtaca gtggaaggtg     540

gataacgccc tccaatccgg taactcccag gagagtgtca cagagcaaga tagcaaggac     600

agcacctaca gcctcagcag caccctgact ctgagcaaag cagactacga gaagcacaag     660

gtctacgcct gcgaagtcac ccatcagggc ctgagttccc ctgtcacaaa gagcttcaac     720

cggggagagt gttgatgata tc                                              742


<210> 20
<211> 742
<212> DNA
<213> Artificial Sequence


<220> 
<223> Light chain

<400> 20
gacgtcacca tggatatgcg tgtaccagct caactacttg gacttctatt gctttggctt      60

cgtggtgcta gatgtgacat ccagatgacc cagagcccaa gcagcctgag cgccagcgtg     120

ggtgacagag tgaccatcac ctgtagtgcc agtcagagcc ttgagaacag caacggaaac     180

acctacctga attggtacca gcagaagcca ggtaaggctc caaagctgct gatctacaga     240

gtttccaacc gattctctgg tgtgccaagc agattcagcg gtagcggtag cggtaccgac     300

ttcaccctca ccatcagcag cctccagcca gaggacttcg ccacctacta ctgcctccag     360

ctgactcatg tcccatggac cttcggtcag ggcaccaagg tggagatcaa acgcactgtg     420

gctgcaccaa gtgtgttcat cttcccacct agcgatgagc agttgaaatc tggaactgcc     480

tctgtcgtgt gcctcctgaa caacttctac ccacgggagg ccaaggtaca gtggaaggtg     540

gataacgccc tccaatccgg taactcccag gagagtgtca cagagcaaga tagcaaggac     600

agcacctaca gcctcagcag caccctgact ctgagcaaag cagactacga gaagcacaag     660

gtctacgcct gcgaagtcac ccatcagggc ctgagttccc ctgtcacaaa gagcttcaac     720

cggggagagt gttgatgata tc                                              742


<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR-L3 - Residues after

<220> 
<221> SITE
<222> 3
<223> X is any amino acid

<400> 21
Phe Gly Xaa Gly 
1               

<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR-H1 - Residues before

<220> 
<221> SITE
<222> 2
<223> X is any amino acid

<220> 
<221> SITE
<222> 3
<223> X is any amino acid

<220> 
<221> SITE
<222> 4
<223> X is any amino acid

<400> 22
Cys Xaa Xaa Xaa 
1               

<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR-H2 - Residues before

<400> 23
Leu Glu Trp Ile Gly 
1               5   

<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR-H3 - Residues after

<220> 
<221> SITE
<222> 3
<223> X is any amino acid

<400> 24
Trp Gly Xaa Gly 
1               

<210> 25
<211> 527
<212> PRT
<213> Homo sapiens


<400> 25
Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      
Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          
Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              
Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  
Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  
Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      
Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         
Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             
Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 
Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 
Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     
Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         
Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             
Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 
Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 
Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys 
                245                 250                 255     
Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         
Gln Phe Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro 
        275                 280                 285             
Trp Gln Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg 
    290                 295                 300                 
Phe Leu Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala 
305                 310                 315                 320 
Ala His Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile 
                325                 330                 335     
Leu Gly Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe 
            340                 345                 350         
Glu Val Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr 
        355                 360                 365             
Asp Asn Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys 
    370                 375                 380                 
Ala Gln Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp 
385                 390                 395                 400 
Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys 
                405                 410                 415     
His Glu Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His 
            420                 425                 430         
Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn 
        435                 440                 445             
Arg Thr Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly 
    450                 455                 460                 
Gly Pro Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly 
465                 470                 475                 480 
Pro Leu Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile 
                485                 490                 495     
Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr 
            500                 505                 510         
Lys Val Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
        515                 520                 525         

<210> 26
<211> 275
<212> PRT
<213> Homo sapiens


<400> 26
Ser Tyr Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln 
1               5                   10                  15      
Gln His Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu 
            20                  25                  30          
Tyr Cys Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val 
        35                  40                  45              
Lys Ser Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln 
    50                  55                  60                  
Ala Leu Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala 
65                  70                  75                  80  
Gly Lys Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln 
                85                  90                  95      
Gly Ile Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu 
            100                 105                 110         
Cys Thr Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly 
        115                 120                 125             
Arg Arg Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys 
    130                 135                 140                 
Arg Asn Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala 
145                 150                 155                 160 
Gly Lys Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly 
                165                 170                 175     
Asn Ser Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His 
            180                 185                 190         
Ser Leu Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile 
        195                 200                 205             
Leu Ile Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu 
    210                 215                 220                 
Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys 
225                 230                 235                 240 
Pro Trp Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys 
                245                 250                 255     
Asp Val Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro 
            260                 265                 270         
Gln Phe Arg 
        275 

<210> 27
<211> 252
<212> PRT
<213> Homo sapiens


<400> 27
Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln Ala 
1               5                   10                  15      
Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu Cys 
            20                  25                  30          
Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His Cys 
        35                  40                  45              
Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly Arg 
    50                  55                  60                  
Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val Glu 
65                  70                  75                  80  
Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn Asp 
                85                  90                  95      
Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln Glu 
            100                 105                 110         
Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln Leu 
        115                 120                 125             
Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu Ala 
    130                 135                 140                 
Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg Leu 
145                 150                 155                 160 
Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr Val 
                165                 170                 175     
Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro Gln 
            180                 185                 190         
Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             
Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp Gly 
    210                 215                 220                 
Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr 
225                 230                 235                 240 
Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
                245                 250         

