               SEQUENCE LISTING

<110> B.R.A.H.M.S GmbH

<120> proADM AND/OR HISTONES AS MARKERS INDICATING AN ADVERSE EVENT

<130> Z1852 PCT/A BLN

<150> EP 17 15 4348.1
<151> 2017-02-02

<160> 16

<170> BiSSAP 1.2

<210> 1
<211> 102
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of human histone H4, uniprot ID P62805.2,
      initial methionine not included

<400> 1
Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys 
1               5                   10                  15      
Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys Pro 
            20                  25                  30          
Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly 
        35                  40                  45              
Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu Asn 
    50                  55                  60                  
Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr 
65                  70                  75                  80  
Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr 
                85                  90                  95      
Leu Tyr Gly Phe Gly Gly 
            100         

<210> 2
<211> 130
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of human histone H2A type 1, uniprot ID
      Q96QV6, initial methionine not included

<400> 2
Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ser Lys Ser 
1               5                   10                  15      
Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Ile His Arg 
            20                  25                  30          
Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Ile Gly Ala Gly Ala Pro 
        35                  40                  45              
Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu Glu 
    50                  55                  60                  
Leu Ala Gly Asn Ala Ser Arg Asp Asn Lys Lys Thr Arg Ile Ile Pro 
65                  70                  75                  80  
Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys Leu 
                85                  90                  95      
Leu Gly Gly Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile Gln 
            100                 105                 110         
Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His His Lys Ala Gln 
        115                 120                 125             
Ser Lys 
    130 

<210> 3
<211> 135
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of human histone H3.1, uniprot ID P68431.2,
      initial methionine not included

<400> 3
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro 
1               5                   10                  15      
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr 
            20                  25                  30          
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu 
        35                  40                  45              
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys 
    50                  55                  60                  
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr 
65                  70                  75                  80  
Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala Cys 
                85                  90                  95      
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile 
            100                 105                 110         
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg 
        115                 120                 125             
Arg Ile Arg Gly Glu Arg Ala 
    130                 135 

<210> 4
<211> 126
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of human histone H2B, uniprot ID P62807

<400> 4
Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      
Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          
Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              
Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  
Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  
Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      
Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         
Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     

<210> 5
<211> 185
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of pre-pro-ADM

<400> 5
Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      
Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          
Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              
Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  
Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  
Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      
Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         
Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             
Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 
Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 
Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     
Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210> 6
<211> 48
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of MR-proADM (AS 45-92 of pre-pro-ADM)

<400> 6
Glu Leu Arg Met Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys 
1               5                   10                  15      
Ala Gly Pro Ala Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala 
            20                  25                  30          
Ser Arg Ser Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val 
        35                  40                  45              



<210> 7
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> position 21-29 of SEQ ID NO:2

<400> 7
Ala Gly Leu Gln Phe Pro Val Gly Arg 
1               5                   

<210> 8
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 82-88 of SEQ ID NO:2

<400> 8
His Leu Gln Leu Ala Ile Arg 
1               5           

<210> 9
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 89-95 of SEQ ID NO:2

<400> 9
Asn Asp Glu Glu Leu Asn Lys 
1               5           

<210> 10
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 100-118 of SEQ ID NO:2

<400> 10
Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile Gln Ala Val Leu 
1               5                   10                  15      
Leu Pro Lys 
            

<210> 11
<211> 57
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 46-102 of SEQ ID NO:1

<400> 11
Ile Ser Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe 
1               5                   10                  15      
Leu Glu Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys 
            20                  25                  30          
Arg Lys Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln 
        35                  40                  45              
Gly Arg Thr Leu Tyr Gly Phe Gly Gly 
    50                  55          

<210> 12
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 46-55 of SEQ ID NO:1

<400> 12
Ile Ser Gly Leu Ile Tyr Glu Glu Thr Arg 
1               5                   10  

<210> 13
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 60-67 of SEQ ID NO:1

<400> 13
Val Phe Leu Glu Asn Val Ile Arg 
1               5               

<210> 14
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 80-91 with acetylated K91 of SEQ
      ID NO:1

<400> 14
Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys 
1               5                   10          

<210> 15
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 24-35 of SEQ ID NO:1

<400> 15
Asp Asn Ile Gln Gly Ile Thr Lys Pro Ala Ile Arg 
1               5                   10          

<210> 16
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> amino acid sequence of residues 68-77 of SEQ ID NO:1

<400> 16
Asp Ala Val Thr Tyr Thr Glu His Ala Lys 
1               5                   10  

