               SEQUENCE LISTING

<110> Bayer Aktiengesellschaft
      Bayer Pharma Aktiengesellschaft
      The Broad Institute, Inc.
      Dana-Farber Cancer Institute, Inc.

<120> COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER TREATMENT

<130> BHC173005

<160> 10

<170> BiSSAP 1.3.6

<210> 1
<211> 519
<212> PRT
<213> DH10B-R


<220> 
<223> Lab host: DH10B-R

<400> 1
Met Asp Ala Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly 
1               5                   10                  15      
Ser Ser Phe Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn 
            20                  25                  30          
Asn Ala His Phe Pro Glu His Leu Asp His Phe Thr Glu Asn Met Glu 
        35                  40                  45              
Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu 
    50                  55                  60                  
Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Thr Pro 
65                  70                  75                  80  
Gly Ile Gln Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro 
                85                  90                  95      
Gln Ser Pro Leu Val Pro Ile Lys Met Glu Asp Thr Thr Gln Asp Ala 
            100                 105                 110         
Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile Met Val 
        115                 120                 125             
Lys Gln Glu Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro 
    130                 135                 140                 
Ser Ala Met Ala Ala Ala Ala Ala Met Ala Thr Thr Pro Leu Leu Gly 
145                 150                 155                 160 
Leu Ser Pro Leu Ser Arg Leu Pro Ile Pro His Gln Ala Pro Gly Glu 
                165                 170                 175     
Met Thr Gln Leu Pro Val Ile Lys Ala Glu Pro Leu Glu Val Asn Gln 
            180                 185                 190         
Phe Leu Lys Val Thr Pro Glu Asp Leu Val Gln Met Pro Pro Thr Pro 
        195                 200                 205             
Pro Ser Ser His Gly Ser Asp Ser Asp Gly Ser Gln Ser Pro Arg Ser 
    210                 215                 220                 
Leu Pro Pro Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Thr Ala 
225                 230                 235                 240 
Ile Ser Thr Ser Pro Leu Leu Thr Pro Pro His Lys Leu Gln Gly Thr 
                245                 250                 255     
Ser Gly Pro Leu Leu Leu Thr Glu Glu Glu Lys Arg Thr Leu Ile Ala 
            260                 265                 270         
Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Thr Lys Ala Glu Glu 
        275                 280                 285             
Lys Ala Leu Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala 
    290                 295                 300                 
Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys 
305                 310                 315                 320 
Lys Val Glu Thr Phe Thr Ser Glu Asn Asn Glu Leu Trp Lys Lys Val 
                325                 330                 335     
Glu Thr Leu Glu Asn Ala Asn Arg Thr Leu Leu Gln Gln Leu Gln Lys 
            340                 345                 350         
Leu Gln Thr Leu Val Thr Asn Lys Ile Ser Arg Pro Tyr Lys Met Ala 
        355                 360                 365             
Ala Thr Gln Thr Gly Thr Cys Leu Met Val Ala Ala Leu Cys Phe Val 
    370                 375                 380                 
Leu Val Leu Gly Ser Leu Val Pro Cys Leu Pro Glu Phe Ser Ser Gly 
385                 390                 395                 400 
Ser Gln Thr Val Lys Glu Asp Pro Leu Ala Ala Asp Gly Val Tyr Thr 
                405                 410                 415     
Ala Ser Gln Met Pro Ser Arg Ser Leu Leu Phe Tyr Asp Asp Gly Ala 
            420                 425                 430         
Gly Leu Trp Glu Asp Gly Arg Ser Thr Leu Leu Pro Met Glu Pro Pro 
        435                 440                 445             
Asp Gly Trp Glu Ile Asn Pro Gly Gly Pro Ala Glu Gln Arg Pro Arg 
    450                 455                 460                 
Asp His Leu Gln His Asp His Leu Asp Ser Thr His Glu Thr Thr Lys 
465                 470                 475                 480 
Tyr Leu Ser Glu Ala Trp Pro Lys Asp Gly Gly Asn Gly Thr Ser Pro 
                485                 490                 495     
Asp Phe Ser His Ser Lys Glu Trp Phe His Asp Arg Asp Leu Gly Pro 
            500                 505                 510         
Asn Thr Thr Ile Lys Leu Ser 
        515                 

<210> 2
<211> 2741
<212> DNA
<213> DH10B-R


<400> 2
ccagccaggg gttcccggtt tcacagagag gaaagtgaca gaagacgtgc ggagggagac      60

gcagagacag aggagaggcc ggcagccacc cagtctcggg ggagcactta gctcccccgc     120

cccggctccc accctgtccg gggggctcct gaagccctca gccccaaccc cgggctcccc     180

atggaagcca gctgtgcccc aggaggagca ggaggaggtg gagtcggctg aatgcccacg     240

gtgcgcccgg ggcccctgag cccatcccgc tcctagccgc tgccctaagg cccccgcgcg     300

ccccgcgccc cccacccggg gccgcgccgc ctccgtccgc ccctcccccg gggcttcgcc     360

ccggacctgc cccccgcccg tttgccagcg ctcaggcagg agctctggac tgggcgcgcc     420

gccgccctgg agtgagggaa gcccagtgga agggggtccc gggagccggc tgcgatggac     480

gccgtcttgg aacccttccc ggccgacagg ctgttccccg gatccagctt cctggacttg     540

ggggatctga acgagtcgga cttcctcaac aatgcgcact ttcctgagca cctggaccac     600

tttacggaga acatggagga cttctccaat gacctgttca gcagcttctt tgatgaccct     660

gtgctggatg agaagagccc tctattggac atggaactgg actcccctac gccaggcatc     720

caggcggagc acagctactc cctgagcggc gactcagcgc cccagagccc ccttgtgccc     780

atcaagatgg aggacaccac ccaagatgca gagcatggag catgggcgct gggacacaaa     840

ctgtgctcca tcatggtgaa gcaggagcag agcccggagc tgcccgtgga ccctctggct     900

gccccctcgg ccatggctgc cgcggccgcc atggccacca ccccgctgct gggcctcagc     960

cccttgtcca ggctgcccat cccccaccag gccccgggag agatgactca gctgccagtg    1020

atcaaagcag agcctctgga ggtgaaccag ttcctcaaag tgacaccgga ggacctggtg    1080

cagatgcctc cgacgccccc cagcagccat ggcagtgaca gcgacggctc ccagagtccc    1140

cgctctctgc ccccctccag ccctgtcagg cccatggcgc gctcctccac ggccatctcc    1200

acctccccac tcctcactgc ccctcacaaa ttacagggga catcagggcc actgctcctg    1260

acagaggagg agaagcggac cctgattgct gagggctacc ccatccccac aaaactcccc    1320

ctcaccaaag ccgaggagaa ggccttgaag agagtccgga ggaaaatcaa gaacaagatc    1380

tcagcccagg agagccgtcg taagaagaag gagtatgtgg agtgtctaga aaagaaggtg    1440

gagacattta catctgagaa caatgaactg tggaagaagg tggagaccct ggagaatgcc    1500

aacaggaccc tgctccagca gctgcagaaa ctccagactc tggtcaccaa caagatctcc    1560

agaccttaca agatggccgc cacccagact gggacctgcc tcatggtggc agccttgtgc    1620

tttgttctgg tgctgggctc cctcgtgccc tgccttcccg agttctcctc cggctcccag    1680

actgtgaagg aagaccccct ggccgcagac ggcgtctaca cggccagcca gatgccctcc    1740

cgaagcctcc tattctacga tgacggggca ggcttatggg aagatggccg cagcaccctg    1800

ctgcccatgg agcccccaga tggctgggaa atcaaccccg gggggccggc agagcagcgg    1860

ccccgggacc acctgcagca tgatcacctg gacagcaccc acgagaccac caagtacctg    1920

agtgaggcct ggcctaaaga cggtggaaac ggcaccagcc ccgacttctc ccactccaag    1980

gagtggttcc acgacaggga tctgggcccc aacaccacca tcaaactctc ctaggccatg    2040

ccaagaccca ggacatagga cggacccctg gtacccagaa gaggagttct tgctcactaa    2100

cccggatccg cctcgtgccc ctgcctcctg gagcttccca ttccaggaga aaaggctcca    2160

cttcccagcc cttccttgcc cctgacattt ggactcttcc cttgggccga ccactctgtt    2220

ctcattctcc ttcccaccaa catccatccg tccttctcag acaaaccact cactgggtac    2280

cccacctcct ctctcatatg cccaacacga ccactgcctc cctgccccca cacctgcacc    2340

caaacagaca catcaacgca ccccactcac agacacccct taccccaccc ccactgtaca    2400

gagaccaaga acagaaattg tttgtaaata atgaacctta ttttttatta ttgccaatcc    2460

cctaagatat tgtattttac aaatctccct cttcccttcg cccctccctt gttttatatt    2520

ttatgaagtt agtgcgggct ttgctgctcc ctggcccagg aaagagggac tacctgaccc    2580

tcacctggca cccccctgct gctgcccaag ccgctgggcc tttttaattg ccaaactgct    2640

ctcttcatca gctcagcaca tgctttaaga aagcaaaacc aaaaaaaaaa aaaaaaagat    2700

gcagcatcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                        2741


<210> 3
<211> 1141
<212> PRT
<213> Homo sapiens


<220> 
<223> human full-length PDE3A amino acid sequence

<400> 3
Met Ala Val Pro Gly Asp Ala Ala Arg Val Arg Asp Lys Pro Val His 
1               5                   10                  15      
Ser Gly Val Ser Gln Ala Pro Thr Ala Gly Arg Asp Cys His His Arg 
            20                  25                  30          
Ala Asp Pro Ala Ser Pro Arg Asp Ser Gly Cys Arg Gly Cys Trp Gly 
        35                  40                  45              
Asp Leu Val Leu Gln Pro Leu Arg Ser Ser Arg Lys Leu Ser Ser Ala 
    50                  55                  60                  
Leu Cys Ala Gly Ser Leu Ser Phe Leu Leu Ala Leu Leu Val Arg Leu 
65                  70                  75                  80  
Val Arg Gly Glu Val Gly Cys Asp Leu Glu Gln Cys Lys Glu Ala Ala 
                85                  90                  95      
Ala Ala Glu Glu Glu Glu Ala Ala Pro Gly Ala Glu Gly Gly Val Phe 
            100                 105                 110         
Pro Gly Pro Arg Gly Gly Ala Pro Gly Gly Gly Ala Arg Leu Ser Pro 
        115                 120                 125             
Trp Leu Gln Pro Ser Ala Leu Leu Phe Ser Leu Leu Cys Ala Phe Phe 
    130                 135                 140                 
Trp Met Gly Leu Tyr Leu Leu Arg Ala Gly Val Arg Leu Pro Leu Ala 
145                 150                 155                 160 
Val Ala Leu Leu Ala Ala Cys Cys Gly Gly Glu Ala Leu Val Gln Ile 
                165                 170                 175     
Gly Leu Gly Val Gly Glu Asp His Leu Leu Ser Leu Pro Ala Ala Gly 
            180                 185                 190         
Val Val Leu Ser Cys Leu Ala Ala Ala Thr Trp Leu Val Leu Arg Leu 
        195                 200                 205             
Arg Leu Gly Val Leu Met Ile Ala Leu Thr Ser Ala Val Arg Thr Val 
    210                 215                 220                 
Ser Leu Ile Ser Leu Glu Arg Phe Lys Val Ala Trp Arg Pro Tyr Leu 
225                 230                 235                 240 
Ala Tyr Leu Ala Gly Val Leu Gly Ile Leu Leu Ala Arg Tyr Val Glu 
                245                 250                 255     
Gln Ile Leu Pro Gln Ser Ala Glu Ala Ala Pro Arg Glu His Leu Gly 
            260                 265                 270         
Ser Gln Leu Ile Ala Gly Thr Lys Glu Asp Ile Pro Val Phe Lys Arg 
        275                 280                 285             
Arg Arg Arg Ser Ser Ser Val Val Ser Ala Glu Met Ser Gly Cys Ser 
    290                 295                 300                 
Ser Lys Ser His Arg Arg Thr Ser Leu Pro Cys Ile Pro Arg Glu Gln 
305                 310                 315                 320 
Leu Met Gly His Ser Glu Trp Asp His Lys Arg Gly Pro Arg Gly Ser 
                325                 330                 335     
Gln Ser Ser Gly Thr Ser Ile Thr Val Asp Ile Ala Val Met Gly Glu 
            340                 345                 350         
Ala His Gly Leu Ile Thr Asp Leu Leu Ala Asp Pro Ser Leu Pro Pro 
        355                 360                 365             
Asn Val Cys Thr Ser Leu Arg Ala Val Ser Asn Leu Leu Ser Thr Gln 
    370                 375                 380                 
Leu Thr Phe Gln Ala Ile His Lys Pro Arg Val Asn Pro Val Thr Ser 
385                 390                 395                 400 
Leu Ser Glu Asn Tyr Thr Cys Ser Asp Ser Glu Glu Ser Ser Glu Lys 
                405                 410                 415     
Asp Lys Leu Ala Ile Pro Lys Arg Leu Arg Arg Ser Leu Pro Pro Gly 
            420                 425                 430         
Leu Leu Arg Arg Val Ser Ser Thr Trp Thr Thr Thr Thr Ser Ala Thr 
        435                 440                 445             
Gly Leu Pro Thr Leu Glu Pro Ala Pro Val Arg Arg Asp Arg Ser Thr 
    450                 455                 460                 
Ser Ile Lys Leu Gln Glu Ala Pro Ser Ser Ser Pro Asp Ser Trp Asn 
465                 470                 475                 480 
Asn Pro Val Met Met Thr Leu Thr Lys Ser Arg Ser Phe Thr Ser Ser 
                485                 490                 495     
Tyr Ala Ile Ser Ala Ala Asn His Val Lys Ala Lys Lys Gln Ser Arg 
            500                 505                 510         
Pro Gly Ala Leu Ala Lys Ile Ser Pro Leu Ser Ser Pro Cys Ser Ser 
        515                 520                 525             
Pro Leu Gln Gly Thr Pro Ala Ser Ser Leu Val Ser Lys Ile Ser Ala 
    530                 535                 540                 
Val Gln Phe Pro Glu Ser Ala Asp Thr Thr Ala Lys Gln Ser Leu Gly 
545                 550                 555                 560 
Ser His Arg Ala Leu Thr Tyr Thr Gln Ser Ala Pro Asp Leu Ser Pro 
                565                 570                 575     
Gln Ile Leu Thr Pro Pro Val Ile Cys Ser Ser Cys Gly Arg Pro Tyr 
            580                 585                 590         
Ser Gln Gly Asn Pro Ala Asp Glu Pro Leu Glu Arg Ser Gly Val Ala 
        595                 600                 605             
Thr Arg Thr Pro Ser Arg Thr Asp Asp Thr Ala Gln Val Thr Ser Asp 
    610                 615                 620                 
Tyr Glu Thr Asn Asn Asn Ser Asp Ser Ser Asp Ile Val Gln Asn Glu 
625                 630                 635                 640 
Asp Glu Thr Glu Cys Leu Arg Glu Pro Leu Arg Lys Ala Ser Ala Cys 
                645                 650                 655     
Ser Thr Tyr Ala Pro Glu Thr Met Met Phe Leu Asp Lys Pro Ile Leu 
            660                 665                 670         
Ala Pro Glu Pro Leu Val Met Asp Asn Leu Asp Ser Ile Met Glu Gln 
        675                 680                 685             
Leu Asn Thr Trp Asn Phe Pro Ile Phe Asp Leu Val Glu Asn Ile Gly 
    690                 695                 700                 
Arg Lys Cys Gly Arg Ile Leu Ser Gln Val Ser Tyr Arg Leu Phe Glu 
705                 710                 715                 720 
Asp Met Gly Leu Phe Glu Ala Phe Lys Ile Pro Ile Arg Glu Phe Met 
                725                 730                 735     
Asn Tyr Phe His Ala Leu Glu Ile Gly Tyr Arg Asp Ile Pro Tyr His 
            740                 745                 750         
Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu Thr 
        755                 760                 765             
Thr Gln Pro Ile Pro Gly Leu Ser Thr Val Ile Asn Asp His Gly Ser 
    770                 775                 780                 
Thr Ser Asp Ser Asp Ser Asp Ser Gly Phe Thr His Gly His Met Gly 
785                 790                 795                 800 
Tyr Val Phe Ser Lys Thr Tyr Asn Val Thr Asp Asp Lys Tyr Gly Cys 
                805                 810                 815     
Leu Ser Gly Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val Ala 
            820                 825                 830         
Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe Leu 
        835                 840                 845             
Val Ala Thr Ser Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser Val 
    850                 855                 860                 
Leu Glu Asn His His Ala Ala Ala Ala Trp Asn Leu Phe Met Ser Arg 
865                 870                 875                 880 
Pro Glu Tyr Asn Phe Leu Ile Asn Leu Asp His Val Glu Phe Lys His 
                885                 890                 895     
Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys Lys 
            900                 905                 910         
His Phe Asp Phe Val Ala Lys Phe Asn Gly Lys Val Asn Asp Asp Val 
        915                 920                 925             
Gly Ile Asp Trp Thr Asn Glu Asn Asp Arg Leu Leu Val Cys Gln Met 
    930                 935                 940                 
Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Cys Lys Glu Leu 
945                 950                 955                 960 
His Leu Gln Trp Thr Asp Gly Ile Val Asn Glu Phe Tyr Glu Gln Gly 
                965                 970                 975     
Asp Glu Glu Ala Ser Leu Gly Leu Pro Ile Ser Pro Phe Met Asp Arg 
            980                 985                 990         
Ser Ala Pro Gln Leu Ala Asn Leu Gln Glu Ser Phe Ile Ser His Ile 
        995                 1000                1005            
Val Gly Pro Leu Cys Asn Ser Tyr Asp Ser Ala Gly Leu Met Pro Gly 
    1010                1015                1020                
Lys Trp Val Glu Asp Ser Asp Glu Ser Gly Asp Thr Asp Asp Pro Glu 
1025                1030                1035                1040
Glu Glu Glu Glu Glu Ala Pro Ala Pro Asn Glu Glu Glu Thr Cys Glu 
                1045                1050                1055    
Asn Asn Glu Ser Pro Lys Lys Lys Thr Phe Lys Arg Arg Lys Ile Tyr 
            1060                1065                1070        
Cys Gln Ile Thr Gln His Leu Leu Gln Asn His Lys Met Trp Lys Lys 
        1075                1080                1085            
Val Ile Glu Glu Glu Gln Arg Leu Ala Gly Ile Glu Asn Gln Ser Leu 
    1090                1095                1100                
Asp Gln Thr Pro Gln Ser His Ser Ser Glu Gln Ile Gln Ala Ile Lys 
1105                1110                1115                1120
Glu Glu Glu Glu Glu Lys Gly Lys Pro Arg Gly Glu Glu Ile Pro Thr 
                1125                1130                1135    
Gln Lys Pro Asp Gln 
            1140    

<210> 4
<211> 7319
<212> RNA
<213> Homo sapiens


<220> 
<223> transcript variant 1

<400> 4
gggggccact gggaattcag tgaagagggc accctatacc atggcagtgc ccggcgacgc       60

tgcacgagtc agggacaagc ccgtccacag tggggtgagt caagccccca cggcgggccg      120

ggactgccac catcgtgcgg accccgcatc gccgcgggac tcgggctgcc gtggctgctg      180

gggagacctg gtgctgcagc cgctccggag ctctcggaaa ctttcctccg cgctgtgcgc      240

gggctccctg tcctttctgc tggcgctgct ggtgaggctg gtccgcgggg aggtcggctg      300

tgacctggag cagtgtaagg aggcggcggc ggcggaggag gaggaagcag ccccgggagc      360

agaagggggc gtcttcccgg ggcctcgggg aggtgctccc gggggcggtg cgcggctcag      420

cccctggctg cagccctcgg cgctgctctt cagtctcctg tgtgccttct tctggatggg      480

cttgtacctc ctgcgcgccg gggtgcgcct gcctctggct gtcgcgctgc tggccgcctg      540

ctgcgggggg gaagcgctcg tccagattgg gctgggcgtc ggggaggatc acttactctc      600

actccccgcc gcgggggtgg tgctcagctg cttggccgcc gcgacatggc tggtgctgag      660

gctgaggctg ggcgtcctca tgatcgcctt gactagcgcg gtcaggaccg tgtccctcat      720

ttccttagag aggttcaagg tcgcctggag accttacctg gcgtacctgg ccggcgtgct      780

ggggatcctc ttggccaggt acgtggaaca aatcttgccg cagtccgcgg aggcggctcc      840

aagggagcat ttggggtccc agctgattgc tgggaccaag gaagatatcc cggtgtttaa      900

gaggaggagg cggtccagct ccgtcgtgtc cgccgagatg tccggctgca gcagcaagtc      960

ccatcggagg acctccctgc cctgtatacc gagggaacag ctcatggggc attcagaatg     1020

ggaccacaaa cgagggccaa gaggatcaca gtcttcagga accagtatta ctgtggacat     1080

cgccgtcatg ggcgaggccc acggcctcat taccgacctc ctggcagacc cttctcttcc     1140

accaaacgtg tgcacatcct tgagagccgt gagcaacttg ctcagcacac agctcacctt     1200

ccaggccatt cacaagccca gagtgaatcc cgtcacttcg ctcagtgaaa actatacctg     1260

ttctgactct gaagagagct ctgaaaaaga caagcttgct attccaaagc gcctgagaag     1320

gagtttgcct cctggcttgt tgagacgagt ttcttccact tggaccacca ccacctcggc     1380

cacaggtcta cccaccttgg agcctgcacc agtacggaga gaccgcagca ccagcatcaa     1440

actgcaggaa gcaccttcat ccagtcctga ttcttggaat aatccagtga tgatgaccct     1500

caccaaaagc agatccttta cttcatccta tgctatttct gcagctaacc atgtaaaggc     1560

taaaaagcaa agtcgaccag gtgccctcgc taaaatttca cctctttcat cgccctgctc     1620

ctcacctctc caagggactc ctgccagcag cctggtcagc aaaatttctg cagtgcagtt     1680

tccagaatct gctgacacaa ctgccaaaca aagcctaggt tctcacaggg ccttaactta     1740

cactcagagt gccccagacc tatcccctca aatcctgact ccacctgtta tatgtagcag     1800

ctgtggcaga ccatattccc aagggaatcc tgctgatgag cccctggaga gaagtggggt     1860

agccactcgg acaccaagta gaacagatga cactgctcaa gttacctctg attatgaaac     1920

caataacaac agtgacagca gtgacattgt acagaatgaa gatgaaacag agtgcctgag     1980

agagcctctg aggaaagcat cggcttgcag cacctatgct cctgagacca tgatgtttct     2040

ggacaaacca attcttgctc ccgaacctct tgtcatggat aacctggact caattatgga     2100

gcagctaaat acttggaatt ttccaatttt tgatttagtg gaaaatatag gaagaaaatg     2160

tggccgtatt cttagtcagg tatcttacag actttttgaa gacatgggcc tctttgaagc     2220

ttttaaaatt ccaattaggg aatttatgaa ttattttcat gctttggaga ttggatatag     2280

ggatattcct tatcataaca gaatccatgc cactgatgtt ttacatgctg tttggtatct     2340

tactacacag cctattccag gcctctcaac tgtgattaat gatcatggtt caaccagtga     2400

ttcagattct gacagtggat ttacacatgg acatatggga tatgtattct caaaaacgta     2460

taatgtgaca gatgataaat acggatgtct gtctgggaat atccctgcct tggagttgat     2520

ggcgctgtat gtggctgcag ccatgcacga ttatgatcat ccaggaagga ctaatgcttt     2580

cctggttgca actagtgctc ctcaggcggt gctatataac gatcgttcag ttttggagaa     2640

tcatcacgca gctgctgcat ggaatctttt catgtcccgg ccagagtata acttcttaat     2700

taaccttgac catgtggaat ttaagcattt ccgtttcctt gtcattgaag caattttggc     2760

cactgacctg aagaaacact ttgacttcgt agccaaattt aatggcaagg taaatgatga     2820

tgttggaata gattggacca atgaaaatga tcgtctactg gtttgtcaaa tgtgtataaa     2880

gttggctgat atcaatggtc cagctaaatg taaagaactc catcttcagt ggacagatgg     2940

tattgtcaat gaattttatg aacagggtga tgaagaggcc agccttggat tacccataag     3000

ccccttcatg gatcgttctg ctcctcagct ggccaacctt caggaatcct tcatctctca     3060

cattgtgggg cctctgtgca actcctatga ttcagcagga ctaatgcctg gaaaatgggt     3120

ggaagacagc gatgagtcag gagatactga tgacccagaa gaagaggagg aagaagcacc     3180

agcaccaaat gaagaggaaa cctgtgaaaa taatgaatct ccaaaaaaga agactttcaa     3240

aaggagaaaa atctactgcc aaataactca gcacctctta cagaaccaca agatgtggaa     3300

gaaagtcatt gaagaggagc aacggttggc aggcatagaa aatcaatccc tggaccagac     3360

ccctcagtcg cactcttcag aacagatcca ggctatcaag gaagaagaag aagagaaagg     3420

gaaaccaaga ggcgaggaga taccaaccca aaagccagac cagtgacaat ggatagaatg     3480

ggctgtgttt ccaaacagat tgacttgtca aagactctct tcaagccagc acaacattta     3540

gacacaacac tgtagaaatt tgagatgggc aaatggctat tgcattttgg gattcttcgc     3600

attttgtgtg tatattttta cagtgaggta cattgttaaa aactttttgc tcaaagaagc     3660

tttcacattg caacaccagc ttctaaggat tttttaagga gggaatatat atgtgtgtgt     3720

gtatataagc tcccacatag atacatgtaa aacatattca cacccatgca cgcacacaca     3780

tacacactga aggccacgat tgctggctcc acaatttagt aacatttata ttaagatata     3840

tatatagtgg tcactgtgat ataataaatc ataaaggaaa ccaaatcaca aaggagatgg     3900

tgtggcttag caaggaaaca gtgcaggaaa tgtaggttac caactaagca gcttttgctc     3960

ttagtactga gggatgaaag ttccagagca ttatttgaat tctgatacat cctgccaaca     4020

ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgaaaga gagacagaag     4080

ggaatggttt gagagggtgc ttgtgtgcat gtgtgtgcat atgtaaagag atttttgtgg     4140

tttaagtaac tcagaatagc tgtagcaaat gactgaatac atgtgaacaa acagaaggaa     4200

gttcactctg gagtgtcttt gggaggcagc cattccaaat gccctcctcc atttagcttc     4260

aataaagggc cttttgctga tggagggcac tcaagggctg ggtgagaggg ccacgtgttt     4320

ggtattacat tactgctatg caccacttga aggagctcta tcaccagcct caaacccgaa     4380

agactgaggc attttccagt ctacttgcct aatgaatgta taggaactgt ctatgagtat     4440

ggatgtcact caactaagat caaatcacca tttaagggga tggcattctt tatacctaaa     4500

cacctaagag ctgaagtcag gtcttttaat caggttagaa ttctaaatga tgccagagaa     4560

ggcttgggaa attgtacttc agcgtgatag cctgtgtctt cttaatttgc tgcaaaatat     4620

gtggtagaga aagaaaagga aacagaaaaa tcactctggg ttatatagca agagatgaag     4680

gagaatattt caacacaggg tttttgtgtt gacataggaa aagcctgatt cttggcaact     4740

gttgtagttt gtctttcagg ggtgaaggtc ccactgacaa cccctgttgt ggtgttccac     4800

acgctgtttg ttggggtagc ttccatcggc agtctggccc attgtcagtc atgcttcttc     4860

tggccgggga gattatagag agattgtttg aagattgggt tattattgaa agtctttttt     4920

tttgtttgtt ttgttttggt ttgtttgttt atctacactt gtttatgctg tgagccaaac     4980

ctctatttaa aaagttgata ctcactttca atattttatt tcatattatt atatatgtca     5040

tgatagttat cttgatgtaa atatgaagat ttttttgttt ctgtagatag taaactcttt     5100

ttttaaaaaa ggaaaaggga aacattttta taaagttata ttttaatcac catttttata     5160

cattgtagtt ctctccaagc ccagtaagag aatgatgatt catttgcatg gaggtcgatg     5220

gacaaccaat catctacctt ttctaattta aatgataatc tgatatagtt ttattgccag     5280

ttaaatgagg atgctgcaaa gcatgttttt tcactagtaa cttttgctaa ctgaatgaat     5340

tctgggtcca tatctcccag atgaaaaact gttaaccaat accatatttt atagttggtg     5400

tccatttctt tccaacactg tttgttatga ttcttccttg agtacttata tacagacctg     5460

ctcattatct aaacaatctt accttctaag taaaccttga ttgtgatttc cagtttttat     5520

tttctctgac gtagtagaaa ggaatgttta cattaaaaat acttttgttt ctcataaatg     5580

gatattgtac tccccccttt caaagcatta ttttacaata attcatggca ttttaaaaaa     5640

taaggcaaag ataatacgac aaaaaatata catggtttca aggcaaattc tccaataagt     5700

tggaaaatgt aaaaaggatc aagtggatgc agcctctacc taaataatta aaatatattt     5760

cagtatattt ctgaattaac accaggtctt cattatttag aacttactaa attgttttca     5820

ttttcttagt tttacctgtg tatctccatg tttgcaaaaa ttactataag tcaaattttg     5880

ccagtgaatt taactatttt tctttccttg caattaaggg gaaaaaagca tttatcttat     5940

cttctcatac cccttgcatc taagtactta gcaaagtcaa tattttccca ttttccaaat     6000

gcgtccatct ctaacataaa tattaattga acatagagct atgtttggag tgagtggact     6060

ggcaggacag ttggaagtcc atcacagtct attgacagtt tcatcaaagc tgtatagtcc     6120

aactagtggg gcagcttggc tactatggtg gaagtctcag caaactgcct ggttttgttt     6180

gtttgttttg ttttaaggta caggaaataa gaggaataat agtggccaaa gcaattagaa     6240

catcttcatt ccagaactgt gttcagcaat ccaggcagat tgatacattt ttctttaaaa     6300

ataaattgct attacagcta gacgtcaatt gggataaata aagggatgaa gatccactaa     6360

gtttgtgact ttcatacaca cccagtacat ctcaaaggat gctaagggac attttctgcc     6420

agtagagttc tccccctttt tggtgacagc aatattatta tgttcacatc taactccaga     6480

gcttacttcc tgtggtgcca atgtatttgt tgcaatttac tacattttta tatgagccta     6540

tttataggtg ccattaaact caggtctttc aaatgaaaga gtttctagcc cacttaggga     6600

aaaagataat tgtttagaaa accataaaat caatggtagg aaaagttgga actggttacc     6660

tggatgccat ggttctctgt taaataaagt aagagaccag gtgtattctg agtgtcatca     6720

gtgttatttt cagcatgcta ataaatgtct ttccggttat atatctatct aaattaacct     6780

ttaaaatatt ggtttccttg ataaaagcac cacttttgct tttgttagct gtaatatttt     6840

ttgtcattta gataagacct ggtttggctc tcaataaaag atgaagacag tagctctgta     6900

cagggatata tctatattag tcttcatctg atgaatgaag aaattttctc atattatgtt     6960

caagaaagta tttacttcct aaaaatagaa ttcccgattc tgtctatttt ggttgaatac     7020

cagaacaaat ctttccgttg caatcccagt aaaacgaaag aaaaggaata tcttacagac     7080

tgttcatatt agatgtatgt agactgttaa tttgcaattt ccccatattt cctgcctatc     7140

ttacccagat aactttcttt gaaggtaaaa gctgtgcaaa aggcatgaga ctcaggccta     7200

ctctttgttt aaatgatgga aaaatataaa ttattttcta agtaataaaa gtataaaaat     7260

tatcattata aataaagtct aaagtttgaa attattaatt taaaaaaaaa aaaaaaaaa      7319


<210> 5
<211> 578
<212> PRT
<213> Homo sapiens


<400> 5
Met Asn Ile Ser Val Asp Leu Glu Thr Asn Tyr Ala Glu Leu Val Leu 
1               5                   10                  15      
Asp Val Gly Arg Val Thr Leu Gly Glu Asn Ser Arg Lys Lys Met Lys 
            20                  25                  30          
Asp Cys Lys Leu Arg Lys Lys Gln Asn Glu Ser Val Ser Arg Ala Met 
        35                  40                  45              
Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Lys Ala Glu Ile Glu 
    50                  55                  60                  
Asn Glu Asp Tyr Ser Tyr Thr Lys Asp Gly Ile Gly Leu Asp Leu Glu 
65                  70                  75                  80  
Asn Ser Phe Ser Asn Ile Leu Leu Phe Val Pro Glu Tyr Leu Asp Phe 
                85                  90                  95      
Met Gln Asn Gly Asn Tyr Phe Leu Ile Phe Val Lys Ser Trp Ser Leu 
            100                 105                 110         
Asn Thr Ser Gly Leu Arg Ile Thr Thr Leu Ser Ser Asn Leu Tyr Lys 
        115                 120                 125             
Arg Asp Ile Thr Ser Ala Lys Val Met Asn Ala Thr Ala Ala Leu Glu 
    130                 135                 140                 
Phe Leu Lys Asp Met Lys Lys Thr Arg Gly Arg Leu Tyr Leu Arg Pro 
145                 150                 155                 160 
Glu Leu Leu Ala Lys Arg Pro Cys Val Asp Ile Gln Glu Glu Asn Asn 
                165                 170                 175     
Met Lys Ala Leu Ala Gly Val Phe Phe Asp Arg Thr Glu Leu Asp Arg 
            180                 185                 190         
Lys Glu Lys Leu Thr Phe Thr Glu Ser Thr His Val Glu Ile Lys Asn 
        195                 200                 205             
Phe Ser Thr Glu Lys Leu Leu Gln Arg Ile Lys Glu Ile Leu Pro Gln 
    210                 215                 220                 
Tyr Val Ser Ala Phe Ala Asn Thr Asp Gly Gly Tyr Leu Phe Ile Gly 
225                 230                 235                 240 
Leu Asn Glu Asp Lys Glu Ile Ile Gly Phe Lys Ala Glu Met Ser Asp 
                245                 250                 255     
Leu Asp Asp Leu Glu Arg Glu Ile Glu Lys Ser Ile Arg Lys Met Pro 
            260                 265                 270         
Val His His Phe Cys Met Glu Lys Lys Lys Ile Asn Tyr Ser Cys Lys 
        275                 280                 285             
Phe Leu Gly Val Tyr Asp Lys Gly Ser Leu Cys Gly Tyr Val Cys Ala 
    290                 295                 300                 
Leu Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Lys Glu Pro Asp 
305                 310                 315                 320 
Ser Trp His Val Lys Asp Asn Arg Val Met Gln Leu Thr Arg Lys Glu 
                325                 330                 335     
Trp Ile Gln Phe Met Val Glu Ala Glu Pro Lys Phe Ser Ser Ser Tyr 
            340                 345                 350         
Glu Glu Val Ile Ser Gln Ile Asn Thr Ser Leu Pro Ala Pro His Ser 
        355                 360                 365             
Trp Pro Leu Leu Glu Trp Gln Arg Gln Arg His His Cys Pro Gly Leu 
    370                 375                 380                 
Ser Gly Arg Ile Thr Tyr Thr Pro Glu Asn Leu Cys Arg Lys Leu Phe 
385                 390                 395                 400 
Leu Gln His Glu Gly Leu Lys Gln Leu Ile Cys Glu Glu Met Asp Ser 
                405                 410                 415     
Val Arg Lys Gly Ser Leu Ile Phe Ser Arg Ser Trp Ser Val Asp Leu 
            420                 425                 430         
Gly Leu Gln Glu Asn His Lys Val Leu Cys Asp Ala Leu Leu Ile Ser 
        435                 440                 445             
Gln Asp Ser Pro Pro Val Leu Tyr Thr Phe His Met Val Gln Asp Glu 
    450                 455                 460                 
Glu Phe Lys Gly Tyr Ser Thr Gln Thr Ala Leu Thr Leu Lys Gln Lys 
465                 470                 475                 480 
Leu Ala Lys Ile Gly Gly Tyr Thr Lys Lys Val Cys Val Met Thr Lys 
                485                 490                 495     
Ile Phe Tyr Leu Ser Pro Glu Gly Met Thr Ser Cys Gln Tyr Asp Leu 
            500                 505                 510         
Arg Ser Gln Val Ile Tyr Pro Glu Ser Tyr Tyr Phe Thr Arg Arg Lys 
        515                 520                 525             
Tyr Leu Leu Lys Ala Leu Phe Lys Ala Leu Lys Arg Leu Lys Ser Leu 
    530                 535                 540                 
Arg Asp Gln Phe Ser Phe Ala Glu Asn Leu Tyr Gln Ile Ile Gly Ile 
545                 550                 555                 560 
Asp Cys Phe Gln Lys Asn Asp Lys Lys Met Phe Lys Ser Cys Arg Arg 
                565                 570                 575     
Leu Thr 
        

<210> 6
<211> 2530
<212> RNA
<213> Homo sapiens


<220> 
<223> transcript variant 1

<400> 6
tttgtaactt cacttcagcc tcccattgat cgctttctgc aaccattcag actgatctcg      60

ggctcctatt tcatttacat tgtgtgcaca ccaagtaacc agtgggaaaa ctttagaggg     120

tacttaaacc ccagaaaatt ctgaaaccgg gctcttgagc cgctatcctc gggcctgctc     180

ccaccctgtg gagtgcactt tcgttttcaa taaatctctg cttttgttgc ttcattcttt     240

ccttgctttg tttgtgtgtt tgtccagttc tttgttcaac acgccaagaa cctggacact     300

cttcactggt aacatatttt ggcaagccaa ccaggagaaa agaatttctg cttggacact     360

gcatagctgc tgggaaaatg aacatcagtg ttgatttgga aacgaattat gccgagttgg     420

ttctagatgt gggaagagtc actcttggag agaacagtag gaaaaaaatg aaggattgta     480

aactgagaaa aaagcagaat gaaagtgtct cacgagctat gtgtgctctg ctcaattctg     540

gagggggagt gatcaaggct gaaattgaga atgaagacta tagttataca aaagatggaa     600

taggactaga tttggaaaat tcttttagta acattctgtt atttgttcct gagtacttag     660

acttcatgca gaatggtaac tactttctga tttttgtgaa gtcatggagc ttgaacacct     720

ctggtctgcg gattaccacc ttgagctcca atttgtacaa aagagatata acatctgcaa     780

aagtcatgaa tgccactgct gcactggagt tcctcaaaga catgaaaaag actagaggga     840

gattgtattt aagaccagaa ttgctggcaa agaggccctg tgttgatata caagaagaaa     900

ataacatgaa ggccttggcc ggggtttttt ttgatagaac agaacttgat cggaaagaaa     960

aattgacctt tactgaatcc acacatgttg aaattaaaaa cttctcgaca gaaaagttgt    1020

tacaacgaat taaagagatt ctccctcaat atgtttctgc atttgcaaat actgatggag    1080

gatatttgtt cattggttta aatgaagata aagaaataat tggctttaaa gcagagatga    1140

gtgacctcga tgacttagaa agagaaatcg aaaagtccat taggaagatg cctgtgcatc    1200

acttctgtat ggagaagaag aagataaatt attcatgcaa attccttgga gtatatgata    1260

aaggaagtct ttgtggatat gtctgtgcac tcagagtgga gcgcttctgc tgtgcagtgt    1320

ttgctaaaga gcctgattcc tggcatgtga aagataaccg tgtgatgcag ttgaccagga    1380

aggaatggat ccagttcatg gtggaggctg aaccaaaatt ttccagttca tatgaagagg    1440

tgatctctca aataaatacg tcattacctg ctccccacag ttggcctctt ttggaatggc    1500

aacggcagag acatcactgt ccagggctat caggaaggat aacgtatact ccagaaaacc    1560

tttgcagaaa actgttctta caacatgaag gacttaagca attaatatgt gaagaaatgg    1620

actctgtcag aaagggctca ctgatcttct ctaggagctg gtctgtggat ctgggcttgc    1680

aagagaacca caaagtcctc tgtgatgctc ttctgatttc ccaggacagt cctccagtcc    1740

tatacacctt ccacatggta caggatgagg agtttaaagg ctattctaca caaactgccc    1800

taaccttaaa gcagaagctg gcaaaaattg gtggttacac taaaaaagtg tgtgtcatga    1860

caaagatctt ctacttgagc cctgaaggca tgacaagctg ccagtatgat ttaaggtcgc    1920

aagtaattta ccctgaatcc tactatttta caagaaggaa atacttgctg aaagcccttt    1980

ttaaagcctt aaagagactc aagtctctga gagaccagtt ttcctttgca gaaaatctat    2040

accagataat cggtatagat tgctttcaga agaatgataa aaagatgttt aaatcttgtc    2100

gaaggctcac ctgatggaaa atggactggg ctactgagat atttttcatt atatatttga    2160

taacattctc taattctgtg aaaatatttc tttgaaaact ttgcaagtta agcaacttaa    2220

tgtgatgttg gataattggg ttttgtctat tttcacttct ccctaaataa tcttcacaga    2280

tattgtttga gggatattag gaaaattaat ttgttaactc gtctgtgcac agtattattt    2340

actctgtctg tagttcctga ataaattttc ttccatgctt gaactgggaa aattgcaaca    2400

cttttattct taatgacaac agtgaaaatc tcccagcata tacctagaaa acaattataa    2460

cttacaaaag attatccttg atgaaactca gaatttccac agtgggaatg aataagaagg    2520

caaaactcat                                                           2530


<210> 7
<211> 3339
<212> RNA
<213> Homo sapiens


<400> 7
atgaggaggg acgagcgaga cgccaaagcc atgcggtccc tgcagccgcc ggatggggcc       60

ggctcgcccc ccgagagtct gaggaacggc tacgtgaaga gctgcgtgag ccccttgcgg      120

caggaccctc cgcgcggctt cttcttccac ctctgccgct tctgcaacgt ggagctgcgg      180

ccgccgccgg cctctcccca gcagccgcgg cgctgctccc ccttctgccg ggcgcgcctc      240

tcgctgggcg ccctggctgc ctttgtcctc gccctgctgc tgggcgcgga acccgagagc      300

tgggctgccg gggccgcctg gctgcggacg ctgctgagcg tgtgttcgca cagcttgagc      360

cccctcttca gcatcgcctg tgccttcttc ttcctcacct gcttcctcac ccggaccaag      420

cggggacccg gcccgggccg gagctgcggc tcctggtggc tgctggcgct gcccgcctgc      480

tgttacctgg gggacttctt ggtgtggcag tggtggtctt ggccttgggg ggatggcgac      540

gcagggtccg cggccccgca cacgcccccg gaggcggcag cgggcaggtt gctgctggtg      600

ctgagctgcg tagggctgct gctgacgctc gcgcacccgc tgcggctccg gcactgcgtt      660

ctggtgctgc tcctggccag cttcgtctgg tgggtctcct tcaccagcct cgggtcgctg      720

ccctccgccc tcaggccgct gctctccggc ctggtggggg gcgctggctg cctgctggcc      780

ctggggttgg atcacttctt tcaaatcagg gaagcgcctc ttcatcctcg actgtccagt      840

gccgccgaag aaaaagtgcc tgtgatccga ccccggagga ggtccagctg cgtgtcgtta      900

ggagaaactg cagccagtta ctatggcagt tgcaaaatat tcaggagacc gtcgttgcct      960

tgtatttcca gagaacagat gattctttgg gattgggact taaaacaatg gtataagcct     1020

cattatcaaa attctggagg tggaaatgga gttgatcttt cagtgctaaa tgaggctcgc     1080

aatatggtgt cagatcttct gactgatcca agccttccac cacaagtcat ttcctctcta     1140

cggagtatta gtagcttaat gggtgctttc tcaggttcct gtaggccaaa gattaatcct     1200

ctcacaccat ttcctggatt ttacccctgt tctgaaatag aggacccagc tgagaaaggg     1260

gatagaaaac ttaacaaggg actaaatagg aatagtttgc caactccaca gctgaggaga     1320

agctcaggaa cttcaggatt gctacctgtt gaacagtctt caaggtggga tcgtaataat     1380

ggcaaaagac ctcaccaaga atttggcatt tcaagtcaag gatgctatct aaatgggcct     1440

tttaattcaa atctactgac tatcccgaag caaaggtcat cttctgtatc actgactcac     1500

catgtaggtc tcagaagagc tggtgttttg tccagtctga gtcctgtgaa ttcttccaac     1560

catggaccag tgtctactgg ctctctaact aatcgatcac ccatagaatt tcctgatact     1620

gctgattttc ttaataagcc aagcgttatc ttgcagagat ctctgggcaa tgcacctaat     1680

actccagatt tttatcagca acttagaaat tctgatagca atctgtgtaa cagctgtgga     1740

catcaaatgc tgaaatatgt ttcaacatct gaatcagatg gtacagattg ctgcagtgga     1800

aaatcaggtg aagaagaaaa cattttctcg aaagaatcat tcaaacttat ggaaactcaa     1860

caagaagagg aaacagagaa gaaagacagc agaaaattat ttcaggaagg tgataagtgg     1920

ctaacagaag aggcacagag tgaacagcaa acaaatattg aacaggaagt atcactggac     1980

ctgattttag tagaagagta tgactcatta atagaaaaga tgagcaactg gaattttcca     2040

atttttgaac ttgtagaaaa gatgggagag aaatcaggaa ggattctcag tcaggttatg     2100

tataccttat ttcaagacac tggtttattg gaaatattta aaattcccac tcaacaattt     2160

atgaactatt ttcgtgcatt agaaaatggc tatcgagaca ttccttatca caatcgtata     2220

catgccacag atgtgctaca tgcagtttgg tatctgacaa cacggccagt tcctggctta     2280

cagcagatcc acaatggttg tggaacagga aatgaaacag attctgatgg tagaattaac     2340

catgggcgaa ttgcttatat ttcttcgaag agctgctcta atcctgatga gagttatggc     2400

tgcctgtctt caaacattcc tgcattagaa ttgatggctc tatacgtggc agctgccatg     2460

catgattatg atcacccagg gaggacaaat gcatttctag tggctacaaa tgcccctcag     2520

gcagttttat acaatgacag atctgttctg gaaaatcatc atgctgcgtc agcttggaat     2580

ctatatcttt ctcgcccaga atacaacttc cttcttcatc ttgatcatgt ggaattcaag     2640

cgctttcgtt ttttagtcat tgaagcaatc cttgctacgg atcttaaaaa gcattttgat     2700

tttctcgcag aattcaatgc caaggcaaat gatgtaaata gtaatggcat agaatggagt     2760

aatgaaaatg atcgcctctt ggtatgccag gtgtgcatca aactggcaga tataaatggc     2820

ccagcaaaag ttcgagactt gcatttgaaa tggacagaag gcattgtcaa tgaattttat     2880

gagcagggag atgaagaagc aaatcttggt ctgcccatca gtccattcat ggatcgttct     2940

tctcctcaac tagcaaaact ccaagaatct tttatcaccc acatagtggg tcccctgtgt     3000

aactcctatg atgctgctgg tttgctacca ggtcagtggt tagaagcaga agaggataat     3060

gatactgaaa gtggtgatga tgaagacggt gaagaattag atacagaaga tgaagaaatg     3120

gaaaacaatc taaatccaaa accaccaaga aggaaaagca gacggcgaat attttgtcag     3180

ctaatgcacc acctcactga aaaccacaag atatggaagg aaatcgtaga ggaagaagaa     3240

aaatgtaaag ctgatgggaa taaactgcag gtggagaatt cctccttacc tcaagcagat     3300

gagattcagg taattgaaga ggcagatgaa gaggaatag                            3339


<210> 8
<211> 1112
<212> PRT
<213> Homo sapiens


<400> 8
Met Arg Arg Asp Glu Arg Asp Ala Lys Ala Met Arg Ser Leu Gln Pro 
1               5                   10                  15      
Pro Asp Gly Ala Gly Ser Pro Pro Glu Ser Leu Arg Asn Gly Tyr Val 
            20                  25                  30          
Lys Ser Cys Val Ser Pro Leu Arg Gln Asp Pro Pro Arg Gly Phe Phe 
        35                  40                  45              
Phe His Leu Cys Arg Phe Cys Asn Val Glu Leu Arg Pro Pro Pro Ala 
    50                  55                  60                  
Ser Pro Gln Gln Pro Arg Arg Cys Ser Pro Phe Cys Arg Ala Arg Leu 
65                  70                  75                  80  
Ser Leu Gly Ala Leu Ala Ala Phe Val Leu Ala Leu Leu Leu Gly Ala 
                85                  90                  95      
Glu Pro Glu Ser Trp Ala Ala Gly Ala Ala Trp Leu Arg Thr Leu Leu 
            100                 105                 110         
Ser Val Cys Ser His Ser Leu Ser Pro Leu Phe Ser Ile Ala Cys Ala 
        115                 120                 125             
Phe Phe Phe Leu Thr Cys Phe Leu Thr Arg Thr Lys Arg Gly Pro Gly 
    130                 135                 140                 
Pro Gly Arg Ser Cys Gly Ser Trp Trp Leu Leu Ala Leu Pro Ala Cys 
145                 150                 155                 160 
Cys Tyr Leu Gly Asp Phe Leu Val Trp Gln Trp Trp Ser Trp Pro Trp 
                165                 170                 175     
Gly Asp Gly Asp Ala Gly Ser Ala Ala Pro His Thr Pro Pro Glu Ala 
            180                 185                 190         
Ala Ala Gly Arg Leu Leu Leu Val Leu Ser Cys Val Gly Leu Leu Leu 
        195                 200                 205             
Thr Leu Ala His Pro Leu Arg Leu Arg His Cys Val Leu Val Leu Leu 
    210                 215                 220                 
Leu Ala Ser Phe Val Trp Trp Val Ser Phe Thr Ser Leu Gly Ser Leu 
225                 230                 235                 240 
Pro Ser Ala Leu Arg Pro Leu Leu Ser Gly Leu Val Gly Gly Ala Gly 
                245                 250                 255     
Cys Leu Leu Ala Leu Gly Leu Asp His Phe Phe Gln Ile Arg Glu Ala 
            260                 265                 270         
Pro Leu His Pro Arg Leu Ser Ser Ala Ala Glu Glu Lys Val Pro Val 
        275                 280                 285             
Ile Arg Pro Arg Arg Arg Ser Ser Cys Val Ser Leu Gly Glu Thr Ala 
    290                 295                 300                 
Ala Ser Tyr Tyr Gly Ser Cys Lys Ile Phe Arg Arg Pro Ser Leu Pro 
305                 310                 315                 320 
Cys Ile Ser Arg Glu Gln Met Ile Leu Trp Asp Trp Asp Leu Lys Gln 
                325                 330                 335     
Trp Tyr Lys Pro His Tyr Gln Asn Ser Gly Gly Gly Asn Gly Val Asp 
            340                 345                 350         
Leu Ser Val Leu Asn Glu Ala Arg Asn Met Val Ser Asp Leu Leu Thr 
        355                 360                 365             
Asp Pro Ser Leu Pro Pro Gln Val Ile Ser Ser Leu Arg Ser Ile Ser 
    370                 375                 380                 
Ser Leu Met Gly Ala Phe Ser Gly Ser Cys Arg Pro Lys Ile Asn Pro 
385                 390                 395                 400 
Leu Thr Pro Phe Pro Gly Phe Tyr Pro Cys Ser Glu Ile Glu Asp Pro 
                405                 410                 415     
Ala Glu Lys Gly Asp Arg Lys Leu Asn Lys Gly Leu Asn Arg Asn Ser 
            420                 425                 430         
Leu Pro Thr Pro Gln Leu Arg Arg Ser Ser Gly Thr Ser Gly Leu Leu 
        435                 440                 445             
Pro Val Glu Gln Ser Ser Arg Trp Asp Arg Asn Asn Gly Lys Arg Pro 
    450                 455                 460                 
His Gln Glu Phe Gly Ile Ser Ser Gln Gly Cys Tyr Leu Asn Gly Pro 
465                 470                 475                 480 
Phe Asn Ser Asn Leu Leu Thr Ile Pro Lys Gln Arg Ser Ser Ser Val 
                485                 490                 495     
Ser Leu Thr His His Val Gly Leu Arg Arg Ala Gly Val Leu Ser Ser 
            500                 505                 510         
Leu Ser Pro Val Asn Ser Ser Asn His Gly Pro Val Ser Thr Gly Ser 
        515                 520                 525             
Leu Thr Asn Arg Ser Pro Ile Glu Phe Pro Asp Thr Ala Asp Phe Leu 
    530                 535                 540                 
Asn Lys Pro Ser Val Ile Leu Gln Arg Ser Leu Gly Asn Ala Pro Asn 
545                 550                 555                 560 
Thr Pro Asp Phe Tyr Gln Gln Leu Arg Asn Ser Asp Ser Asn Leu Cys 
                565                 570                 575     
Asn Ser Cys Gly His Gln Met Leu Lys Tyr Val Ser Thr Ser Glu Ser 
            580                 585                 590         
Asp Gly Thr Asp Cys Cys Ser Gly Lys Ser Gly Glu Glu Glu Asn Ile 
        595                 600                 605             
Phe Ser Lys Glu Ser Phe Lys Leu Met Glu Thr Gln Gln Glu Glu Glu 
    610                 615                 620                 
Thr Glu Lys Lys Asp Ser Arg Lys Leu Phe Gln Glu Gly Asp Lys Trp 
625                 630                 635                 640 
Leu Thr Glu Glu Ala Gln Ser Glu Gln Gln Thr Asn Ile Glu Gln Glu 
                645                 650                 655     
Val Ser Leu Asp Leu Ile Leu Val Glu Glu Tyr Asp Ser Leu Ile Glu 
            660                 665                 670         
Lys Met Ser Asn Trp Asn Phe Pro Ile Phe Glu Leu Val Glu Lys Met 
        675                 680                 685             
Gly Glu Lys Ser Gly Arg Ile Leu Ser Gln Val Met Tyr Thr Leu Phe 
    690                 695                 700                 
Gln Asp Thr Gly Leu Leu Glu Ile Phe Lys Ile Pro Thr Gln Gln Phe 
705                 710                 715                 720 
Met Asn Tyr Phe Arg Ala Leu Glu Asn Gly Tyr Arg Asp Ile Pro Tyr 
                725                 730                 735     
His Asn Arg Ile His Ala Thr Asp Val Leu His Ala Val Trp Tyr Leu 
            740                 745                 750         
Thr Thr Arg Pro Val Pro Gly Leu Gln Gln Ile His Asn Gly Cys Gly 
        755                 760                 765             
Thr Gly Asn Glu Thr Asp Ser Asp Gly Arg Ile Asn His Gly Arg Ile 
    770                 775                 780                 
Ala Tyr Ile Ser Ser Lys Ser Cys Ser Asn Pro Asp Glu Ser Tyr Gly 
785                 790                 795                 800 
Cys Leu Ser Ser Asn Ile Pro Ala Leu Glu Leu Met Ala Leu Tyr Val 
                805                 810                 815     
Ala Ala Ala Met His Asp Tyr Asp His Pro Gly Arg Thr Asn Ala Phe 
            820                 825                 830         
Leu Val Ala Thr Asn Ala Pro Gln Ala Val Leu Tyr Asn Asp Arg Ser 
        835                 840                 845             
Val Leu Glu Asn His His Ala Ala Ser Ala Trp Asn Leu Tyr Leu Ser 
    850                 855                 860                 
Arg Pro Glu Tyr Asn Phe Leu Leu His Leu Asp His Val Glu Phe Lys 
865                 870                 875                 880 
Arg Phe Arg Phe Leu Val Ile Glu Ala Ile Leu Ala Thr Asp Leu Lys 
                885                 890                 895     
Lys His Phe Asp Phe Leu Ala Glu Phe Asn Ala Lys Ala Asn Asp Val 
            900                 905                 910         
Asn Ser Asn Gly Ile Glu Trp Ser Asn Glu Asn Asp Arg Leu Leu Val 
        915                 920                 925             
Cys Gln Val Cys Ile Lys Leu Ala Asp Ile Asn Gly Pro Ala Lys Val 
    930                 935                 940                 
Arg Asp Leu His Leu Lys Trp Thr Glu Gly Ile Val Asn Glu Phe Tyr 
945                 950                 955                 960 
Glu Gln Gly Asp Glu Glu Ala Asn Leu Gly Leu Pro Ile Ser Pro Phe 
                965                 970                 975     
Met Asp Arg Ser Ser Pro Gln Leu Ala Lys Leu Gln Glu Ser Phe Ile 
            980                 985                 990         
Thr His Ile Val Gly Pro Leu Cys Asn Ser Tyr Asp Ala Ala Gly Leu 
        995                 1000                1005            
Leu Pro Gly Gln Trp Leu Glu Ala Glu Glu Asp Asn Asp Thr Glu Ser 
    1010                1015                1020                
Gly Asp Asp Glu Asp Gly Glu Glu Leu Asp Thr Glu Asp Glu Glu Met 
1025                1030                1035                1040
Glu Asn Asn Leu Asn Pro Lys Pro Pro Arg Arg Lys Ser Arg Arg Arg 
                1045                1050                1055    
Ile Phe Cys Gln Leu Met His His Leu Thr Glu Asn His Lys Ile Trp 
            1060                1065                1070        
Lys Glu Ile Val Glu Glu Glu Glu Lys Cys Lys Ala Asp Gly Asn Lys 
        1075                1080                1085            
Leu Gln Val Glu Asn Ser Ser Leu Pro Gln Ala Asp Glu Ile Gln Val 
    1090                1095                1100                
Ile Glu Glu Ala Asp Glu Glu Glu 
1105                1110        

<210> 9
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> PDE3A_sg2 Forward Oligonucleotide

<400> 9
caccgagaca agcttgctat tccaa                                          25


<210> 10
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> PDE3A_sg2 Reverse Oligonucleotide

<400> 10
aaacttggaa tagcaagctt gtctc                                          25


