                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  NEURONAL CELL PROTECTIVE EFFECT OF ANTIBODIES SPECIFIC FOR THE 
       PROTOFIBRILLAR FORM OF THE BETA-AMYLOID PEPTIDE

<130>  BET18P0090

<150>  EP17305110.3
<151>  2017-01-31

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH1+CH1


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  1
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val           
1               5                   10                  15                

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat         96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att        144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt        192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe           
    50                  55                  60                            

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat        240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt        288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc        336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr           
            100                 105                 110                   

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg        432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag        624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc        672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys           
    210                 215                 220                           

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct        720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
225                 230                 235                 240           

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt        768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
                245                 250                 255               

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg        816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp           
            260                 265                 270                   

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag        864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
        275                 280                 285                       

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg        912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
    290                 295                 300                           

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac        960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
305                 310                 315                 320           

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc       1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
                325                 330                 335               

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag       1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu           
            340                 345                 350                   

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac       1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
        355                 360                 365                       

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac       1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
    370                 375                 380                           

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc       1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
385                 390                 395                 400           

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac       1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn           
                405                 410                 415               

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc       1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
            420                 425                 430                   

cag aag tcc ctg tcc ctg tct ctg ggc tga                               1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                       
        435                 440                                           


<210>  2
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  3
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL1+CL1


<220>
<221>  CDS
<222>  (1)..(660)

<400>  3
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt         96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser           
            20                  25                  30                    

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct        144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg        192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn           
                85                  90                  95                

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag        384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
        115                 120                 125                       

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
    130                 135                 140                           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
145                 150                 155                 160           

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
                165                 170                 175               

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
            180                 185                 190                   

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
        195                 200                 205                       

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                        660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
    210                 215                                               


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH1


<220>
<221>  CDS
<222>  (1)..(345)

<400>  5
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val           
1               5                   10                  15                

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat         96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att        144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt        192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe           
    50                  55                  60                            

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat        240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt        288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg gac gat ggt tat tcc tgg ggt caa gga acc tca gtc acc        336
Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr           
            100                 105                 110                   

gtc tcc agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  6
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asp Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL1


<220>
<221>  CDS
<222>  (1)..(339)

<400>  7
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt         96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser           
            20                  25                  30                    

aat gga aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct        144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg        192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn           
                85                  90                  95                

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgt                                                                    339
Arg                                                                       
                                                                          


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 VH1


<220>
<221>  CDS
<222>  (1)..(33)

<400>  9
tcc ggc tac aca ttc act gat tat gct atg cac                             33
Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His                               
1               5                   10                                    


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10      


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 VH1


<220>
<221>  CDS
<222>  (1)..(30)

<400>  11
gtt att agt act aag tat ggt aag aca aac                                 30
Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn                                   
1               5                   10                                    


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn 
1               5                   10  


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 VH1


<220>
<221>  CDS
<222>  (1)..(18)

<400>  13
ggg gac gat ggt tat tcc                                                 18
Gly Asp Asp Gly Tyr Ser                                                   
1               5                                                         


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Asp Asp Gly Tyr Ser 
1               5       


<210>  15
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 VL1


<220>
<221>  CDS
<222>  (1)..(48)

<400>  15
aga tct ggt cag agc ctt gtg cac agt aat gga aac acc tat ctg cat         48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His           
1               5                   10                  15                


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  17
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 VL1


<220>
<221>  CDS
<222>  (1)..(24)

<400>  17
aca gtt tcc aac cga ttt tct ggg                                         24
Thr Val Ser Asn Arg Phe Ser Gly                                           
1               5                                                         


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Thr Val Ser Asn Arg Phe Ser Gly 
1               5               


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 VL1


<220>
<221>  CDS
<222>  (1)..(27)

<400>  19
tct caa aat aca ttt gtt cct tgg acg                                     27
Ser Gln Asn Thr Phe Val Pro Trp Thr                                       
1               5                                                         


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Ser Gln Asn Thr Phe Val Pro Trp Thr 
1               5                   


<210>  21
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL2 + CL2


<220>
<221>  CDS
<222>  (1)..(660)

<400>  21
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt         96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser           
            20                  25                  30                    

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct        144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg        192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn           
                85                  90                  95                

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag        384
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
        115                 120                 125                       

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc        432
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
    130                 135                 140                           

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        480
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
145                 150                 155                 160           

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        528
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
                165                 170                 175               

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        576
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
            180                 185                 190                   

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        624
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
        195                 200                 205                       

ccc gtc aca aag agc ttc aac agg gga gag tgt tga                        660
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
    210                 215                                               


<210>  22
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL2


<220>
<221>  CDS
<222>  (1)..(339)

<400>  23
gag atc gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat aga gcc tcc atc tct tgc aga tct ggt cag agc ctt gtg cac agt         96
Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser           
            20                  25                  30                    

aat acc aac acc tat ctg cat tgg tac ctg cag aag cca ggc cag tct        144
Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tat aca gtt tcc aac cga ttt tct ggg gtc ccg        192
Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg tca gat ttc aca ctc acc atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa aat        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn           
                85                  90                  95                

aca ttt gtt cct tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgt                                                                    339
Arg                                                                       
                                                                          


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Glu Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Thr Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr Phe Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  25
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH2+ CH2


<220>
<221>  CDS
<222>  (1)..(1326)

<400>  25
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val           
1               5                   10                  15                

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat         96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att        144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt        192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe           
    50                  55                  60                            

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat        240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt        288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc        336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr           
            100                 105                 110                   

gtc tcc agc gct tct acc aag ggc cct tcc gtg ttc cct ctg gcc cct        384
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro           
        115                 120                 125                       

tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg ggc tgc ctg gtg        432
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val           
    130                 135                 140                           

aag gac tac ttc cct gag cct gtg acc gtg tcc tgg aac tct ggc gcc        480
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala           
145                 150                 155                 160           

ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg cag tcc tcc ggc        528
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly           
                165                 170                 175               

ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc tcc tcc ctg ggc        576
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly           
            180                 185                 190                   

acc aag acc tac acc tgt aac gtg gac cac aag cct tcc aac acc aag        624
Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys           
        195                 200                 205                       

gtg gac aag cgg gtg gag tcc aag tac ggc cct cct tgc cct ccc tgc        672
Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys           
    210                 215                 220                           

cct gcc cct gag ttc gag ggc gga cct agc gtg ttc ctg ttc cct cct        720
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
225                 230                 235                 240           

aag cct aag gac acc ctg atg atc tcc cgg acc cct gag gtg acc tgt        768
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
                245                 250                 255               

gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc cag ttc aac tgg        816
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp           
            260                 265                 270                   

tac gtg gac ggc gtg gag gtg cac aac gcc aag acc aag cct cgg gag        864
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
        275                 280                 285                       

gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg ctg acc gtg ctg        912
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
    290                 295                 300                           

cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt aag gtc tcc aac        960
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
305                 310                 315                 320           

aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc aag gcc aag ggc       1008
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
                325                 330                 335               

cag cct agg gag cct cag gtg tac acc ctg cct cct agc cag gaa gag       1056
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu           
            340                 345                 350                   

atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg aag ggc ttc tac       1104
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
        355                 360                 365                       

cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc cag cct gag aac       1152
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
    370                 375                 380                           

aac tac aag acc acc cct cct gtg ctg gac tcc gac ggc tcc ttc ttc       1200
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
385                 390                 395                 400           

ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg cag gag ggc aac       1248
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn           
                405                 410                 415               

gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac aac cac tac acc       1296
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
            420                 425                 430                   

cag aag tcc ctg tcc ctg tct ctg ggc tga                               1326
Gln Lys Ser Leu Ser Leu Ser Leu Gly                                       
        435                 440                                           


<210>  26
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440     


<210>  27
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH2


<220>
<221>  CDS
<222>  (1)..(345)

<400>  27
gag gtc cag ctg cag cag tct ggg cct gag gtg gtg aag cct ggg gtc         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val           
1               5                   10                  15                

tca gtg aag att tcc tgc aag ggt tcc ggc tac aca ttc act gat tat         96
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

gct atg cac tgg gtg aag cag agt cct ggc aag agt ctg gag tgg att        144
Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga gtt att agt act aag tat ggt aag aca aac tac aac ccc agc ttt        192
Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe           
    50                  55                  60                            

cag ggc cag gcc aca atg act gtt gac aaa tcc tcc agc aca gcc tat        240
Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctt gcc agc ttg aag gcc tcc gat tct gcc atc tat tac tgt        288
Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg gac gag ggt tat tcc tgg ggt caa gga acc tca gtc acc        336
Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr           
            100                 105                 110                   

gtc tcc agc                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  28
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Lys Tyr Gly Lys Thr Asn Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Glu Gly Tyr Ser Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 VH2


<220>
<221>  CDS
<222>  (1)..(18)

<400>  29
ggg gac gag ggt tat tcc                                                 18
Gly Asp Glu Gly Tyr Ser                                                   
1               5                                                         


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Gly Asp Glu Gly Tyr Ser 
1               5       


<210>  31
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 VL2


<220>
<221>  CDS
<222>  (1)..(48)

<400>  31
aga tct ggt cag agc ctt gtg cac agt aat acc aac acc tat ctg cat         48
Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His           
1               5                   10                  15                


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Arg Ser Gly Gln Ser Leu Val His Ser Asn Thr Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  33
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4 Heavy Chain

<400>  33

Gln Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  34
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4 Light Chain

<400>  34

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  35
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5 Heavy chain

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Gly Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Arg Ser Tyr Tyr Thr Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  36
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5 Light Chain

<400>  36

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Ala Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


